                         SEQUENCE LISTING

<110>  VIB VZW
       UNIVERSITEIT GENT
       The United States of America, as represented by the 
       Secretary of the Department of Health and Human Services
       Board of Regents, The University of Texas System
       Trustees of Dartmouth College
       KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D
       EXEVIR BIO
       VRIJE UNIVERSITEIT BRUSSEL
 
<120>  CORONA VIRUS BINDERS

<130>  XaSa/CORONA/682

<140>  PCT/EP2021/052885
<141>  2021-02-05

<150>  US62/971013
<151>  2020-02-06

<150>  US62/988610
<151>  2020-03-12

<150>  US63/041240
<151>  2020-06-19

<150>  US62/991408
<151>  2020-03-18

<150>  PCT/EP2020/077004
<151>  2020-09-25

<150>  GB 2020508.4
<151>  2020-12-23

<150>  EP 21151356.9
<151>  2021-01-13

<160>  149   

<170>  PatentIn version 3.5

<210>  1
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-72

<400>  1

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  2
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-h1 humanized variant 1 of VHH-72

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  3
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-h1(E1D) humanized variant 1(E1D) of VHH-72

<400>  3

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  4
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-S56A variant

<400>  4

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ala Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  5
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72_h1(S56A) humanized variant 1of VHH72-S56A

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ala Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  6
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72_h1(E1D)(S56A) humanized variant 1(E1D) of VHH72-S56A

<400>  6

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ala Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of VHH-72 (or VHH72-S56A)

<400>  7

Glu Tyr Ala Met Gly 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of VHH-72

<400>  8

Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of VHH-72 (or VHH72-S56A)

<400>  9

Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr Asp Tyr 
1               5                   10                  15      


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of VHH-72-S56A

<400>  10

Thr Ile Ser Trp Ser Gly Gly Ala Thr Tyr Tyr Thr Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  11
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72_h2 humanized variant 2 of VHH72

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  12
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bivalent fusion of VHH-72 with a (Gly4Ser)3 -linker

<400>  12

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
    130                 135                 140                 


Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu 
145                 150                 155                 160 


Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr Ala Met Gly Trp 
                165                 170                 175     


Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Thr Ile Ser 
            180                 185                 190         


Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val Lys Gly Arg Phe 
        195                 200                 205             


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn 
    210                 215                 220                 


Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala Gly 
225                 230                 235                 240 


Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Gln Val Thr Val Ser Ser 
            260                 265 


<210>  13
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-72 fused to human IgG1 Fc with a glycine-serine linker in 
       between

<400>  13

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Cys Asp Lys 
    130                 135                 140                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
145                 150                 155                 160 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                165                 170                 175     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            180                 185                 190         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        195                 200                 205             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    210                 215                 220                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
225                 230                 235                 240 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                245                 250                 255     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            260                 265                 270         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        275                 280                 285             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    290                 295                 300                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
305                 310                 315                 320 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                325                 330                 335     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            340                 345                 350         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        355                 360                 365             


Lys 
    


<210>  14
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mouse VH signal sequence-VHH72-GSGGGGSGGGGS-hIgG1Hinge-hIgG1Fc

<400>  14

Met Gly Trp Ser Cys Ile Ile Phe Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe 
        35                  40                  45              


Ser Glu Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
    50                  55                  60                  


Glu Phe Val Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp 
        115                 120                 125             


Tyr Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
145                 150                 155                 160 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                165                 170                 175     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            180                 185                 190         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        195                 200                 205             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    210                 215                 220                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
225                 230                 235                 240 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                245                 250                 255     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            260                 265                 270         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        275                 280                 285             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    290                 295                 300                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
305                 310                 315                 320 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                325                 330                 335     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            340                 345                 350         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        355                 360                 365             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    370                 375                 380                 


Ser Pro Gly Lys 
385             


<210>  15
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mouse VH signal sequence-VHH72-GSGGGGSGGGGS-hIgG1Hinge-hIgG2Fc

<400>  15

Met Gly Trp Ser Cys Ile Ile Phe Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe 
        35                  40                  45              


Ser Glu Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
    50                  55                  60                  


Glu Phe Val Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp 
        115                 120                 125             


Tyr Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
145                 150                 155                 160 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                165                 170                 175     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            180                 185                 190         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        195                 200                 205             


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    210                 215                 220                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
225                 230                 235                 240 


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
                245                 250                 255     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
            260                 265                 270         


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
        275                 280                 285             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    290                 295                 300                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
305                 310                 315                 320 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                325                 330                 335     


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            340                 345                 350         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        355                 360                 365             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    370                 375                 380                 


Ser Pro Gly Lys 
385             


<210>  16
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mouse VH signal sequence- 
       VHH72-GSGGGGSGGGGS-hIgG2Hinge_ERKCCdel-hIgG2Fc

<400>  16

Met Gly Trp Ser Cys Ile Ile Phe Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe 
        35                  40                  45              


Ser Glu Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
    50                  55                  60                  


Glu Phe Val Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp 
        115                 120                 125             


Tyr Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Glu Cys Pro 
145                 150                 155                 160 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
                165                 170                 175     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            180                 185                 190         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn 
        195                 200                 205             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    210                 215                 220                 


Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val 
225                 230                 235                 240 


Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                245                 250                 255     


Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
            260                 265                 270         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
        275                 280                 285             


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    290                 295                 300                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
305                 310                 315                 320 


Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
                325                 330                 335     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            340                 345                 350         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        355                 360                 365             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 


<210>  17
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D72-58 [VHH72_h1(E1D)_10GS_IgG1_LALA]

<400>  17

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
    130                 135                 140                 


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
145                 150                 155                 160 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                165                 170                 175     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            180                 185                 190         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        195                 200                 205             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    210                 215                 220                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
225                 230                 235                 240 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                245                 250                 255     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
            260                 265                 270         


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        275                 280                 285             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    290                 295                 300                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
305                 310                 315                 320 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                325                 330                 335     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            340                 345                 350         


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        355                 360     


<210>  18
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D72-1 [VHH72-GS(G4S)2-hIgG1hinge-hIgG1Fc]

<400>  18

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Cys Asp Lys 
    130                 135                 140                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
145                 150                 155                 160 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                165                 170                 175     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            180                 185                 190         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        195                 200                 205             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    210                 215                 220                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
225                 230                 235                 240 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                245                 250                 255     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            260                 265                 270         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        275                 280                 285             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    290                 295                 300                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
305                 310                 315                 320 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                325                 330                 335     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            340                 345                 350         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        355                 360                 365             


Lys 
    


<210>  19
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72_h1_S56A-GS-hIgG1hinge-hIgG1Fc_LALAPG (D72-23)

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ala Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Glu 
        115                 120                 125             


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    130                 135                 140                 


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
145                 150                 155                 160 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                165                 170                 175     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            180                 185                 190         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        195                 200                 205             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    210                 215                 220                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
225                 230                 235                 240 


Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                245                 250                 255     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
            260                 265                 270         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        275                 280                 285             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    290                 295                 300                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
305                 310                 315                 320 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                325                 330                 335     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            340                 345                 350         


Leu Ser Leu Ser Pro Gly Lys 
        355                 


<210>  20
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72_h1_E1D_S56A-(G4S)2-hIgG1hinge_EPKSCdel-hIgG1Fc_LALAPG_Kdel 
       (D72-52)

<400>  20

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ala Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
    130                 135                 140                 


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
145                 150                 155                 160 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                165                 170                 175     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            180                 185                 190         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        195                 200                 205             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    210                 215                 220                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
225                 230                 235                 240 


Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                245                 250                 255     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
            260                 265                 270         


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        275                 280                 285             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    290                 295                 300                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
305                 310                 315                 320 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                325                 330                 335     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            340                 345                 350         


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        355                 360     


<210>  21
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72_ h1_E1D 
       _S56A-(G4S)3-VHH72_h3_S56A-GS-hIgG1hinge_EPKSCdel-hIgG1Fc_LALAPG_
       Kdel (D72-55)

<400>  21

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ala Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Leu 
    130                 135                 140                 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
145                 150                 155                 160 


Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr Ala Met Gly Trp 
                165                 170                 175     


Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Thr Ile Ser 
            180                 185                 190         


Trp Ser Gly Gly Ala Thr Tyr Tyr Thr Asp Ser Val Lys Gly Arg Phe 
        195                 200                 205             


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn 
    210                 215                 220                 


Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala Gly 
225                 230                 235                 240 


Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Asp Lys Thr His Thr 
            260                 265                 270         


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
        275                 280                 285             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    290                 295                 300                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
305                 310                 315                 320 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                325                 330                 335     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            340                 345                 350         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        355                 360                 365             


Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser 
    370                 375                 380                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
385                 390                 395                 400 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                405                 410                 415     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            420                 425                 430         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        435                 440                 445             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    450                 455                 460                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
465                 470                 475                 480 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                485                 490             


<210>  22
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72_h1_E1D_S56A-(G4S)2-hIgG1hinge_EPKSCdel-hIgG1Fc_LALA_Kdel 
       (361AA; D72-53 construct)

<400>  22

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ala Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
    130                 135                 140                 


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
145                 150                 155                 160 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                165                 170                 175     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            180                 185                 190         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        195                 200                 205             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    210                 215                 220                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
225                 230                 235                 240 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                245                 250                 255     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
            260                 265                 270         


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        275                 280                 285             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    290                 295                 300                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
305                 310                 315                 320 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                325                 330                 335     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            340                 345                 350         


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        355                 360     


<210>  23
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2

<400>  23

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  24
<211>  1255
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus

<400>  24

Met Phe Ile Phe Leu Leu Phe Leu Thr Leu Thr Ser Gly Ser Asp Leu 
1               5                   10                  15      


Asp Arg Cys Thr Thr Phe Asp Asp Val Gln Ala Pro Asn Tyr Thr Gln 
            20                  25                  30          


His Thr Ser Ser Met Arg Gly Val Tyr Tyr Pro Asp Glu Ile Phe Arg 
        35                  40                  45              


Ser Asp Thr Leu Tyr Leu Thr Gln Asp Leu Phe Leu Pro Phe Tyr Ser 
    50                  55                  60                  


Asn Val Thr Gly Phe His Thr Ile Asn His Thr Phe Gly Asn Pro Val 
65                  70                  75                  80  


Ile Pro Phe Lys Asp Gly Ile Tyr Phe Ala Ala Thr Glu Lys Ser Asn 
                85                  90                  95      


Val Val Arg Gly Trp Val Phe Gly Ser Thr Met Asn Asn Lys Ser Gln 
            100                 105                 110         


Ser Val Ile Ile Ile Asn Asn Ser Thr Asn Val Val Ile Arg Ala Cys 
        115                 120                 125             


Asn Phe Glu Leu Cys Asp Asn Pro Phe Phe Ala Val Ser Lys Pro Met 
    130                 135                 140                 


Gly Thr Gln Thr His Thr Met Ile Phe Asp Asn Ala Phe Asn Cys Thr 
145                 150                 155                 160 


Phe Glu Tyr Ile Ser Asp Ala Phe Ser Leu Asp Val Ser Glu Lys Ser 
                165                 170                 175     


Gly Asn Phe Lys His Leu Arg Glu Phe Val Phe Lys Asn Lys Asp Gly 
            180                 185                 190         


Phe Leu Tyr Val Tyr Lys Gly Tyr Gln Pro Ile Asp Val Val Arg Asp 
        195                 200                 205             


Leu Pro Ser Gly Phe Asn Thr Leu Lys Pro Ile Phe Lys Leu Pro Leu 
    210                 215                 220                 


Gly Ile Asn Ile Thr Asn Phe Arg Ala Ile Leu Thr Ala Phe Ser Pro 
225                 230                 235                 240 


Ala Gln Asp Ile Trp Gly Thr Ser Ala Ala Ala Tyr Phe Val Gly Tyr 
                245                 250                 255     


Leu Lys Pro Thr Thr Phe Met Leu Lys Tyr Asp Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ser Gln Asn Pro Leu Ala Glu Leu Lys Cys 
        275                 280                 285             


Ser Val Lys Ser Phe Glu Ile Asp Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser 
                325                 330                 335     


Val Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser 
            420                 425                 430         


Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu 
        435                 440                 445             


Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly 
    450                 455                 460                 


Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp 
465                 470                 475                 480 


Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Pro Ser Ser Lys Arg 
    530                 535                 540                 


Phe Gln Pro Phe Gln Gln Phe Gly Arg Asp Val Ser Asp Phe Thr Asp 
545                 550                 555                 560 


Ser Val Arg Asp Pro Lys Thr Ser Glu Ile Leu Asp Ile Ser Pro Cys 
                565                 570                 575     


Ala Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Ala Ser Ser 
            580                 585                 590         


Glu Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Asp Val Ser Thr 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Ala Trp Arg Ile Tyr Ser Thr 
    610                 615                 620                 


Gly Asn Asn Val Phe Gln Thr Gln Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asp Thr Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr His Thr Val Ser Leu Leu Arg Ser Thr Ser Gln Lys 
            660                 665                 670         


Ser Ile Val Ala Tyr Thr Met Ser Leu Gly Ala Asp Ser Ser Ile Ala 
        675                 680                 685             


Tyr Ser Asn Asn Thr Ile Ala Ile Pro Thr Asn Phe Ser Ile Ser Ile 
    690                 695                 700                 


Thr Thr Glu Val Met Pro Val Ser Met Ala Lys Thr Ser Val Asp Cys 
705                 710                 715                 720 


Asn Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ala Asn Leu Leu Leu 
                725                 730                 735     


Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Ser Gly Ile 
            740                 745                 750         


Ala Ala Glu Gln Asp Arg Asn Thr Arg Glu Val Phe Ala Gln Val Lys 
        755                 760                 765             


Gln Met Tyr Lys Thr Pro Thr Leu Lys Tyr Phe Gly Gly Phe Asn Phe 
    770                 775                 780                 


Ser Gln Ile Leu Pro Asp Pro Leu Lys Pro Thr Lys Arg Ser Phe Ile 
785                 790                 795                 800 


Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Met 
                805                 810                 815     


Lys Gln Tyr Gly Glu Cys Leu Gly Asp Ile Asn Ala Arg Asp Leu Ile 
            820                 825                 830         


Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
        835                 840                 845             


Asp Asp Met Ile Ala Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr Ala 
    850                 855                 860                 


Thr Ala Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
865                 870                 875                 880 


Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
                885                 890                 895     


Val Leu Tyr Glu Asn Gln Lys Gln Ile Ala Asn Gln Phe Asn Lys Ala 
            900                 905                 910         


Ile Ser Gln Ile Gln Glu Ser Leu Thr Thr Thr Ser Thr Ala Leu Gly 
        915                 920                 925             


Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu 
    930                 935                 940                 


Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn 
945                 950                 955                 960 


Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp 
                965                 970                 975     


Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln 
            980                 985                 990         


Gln Leu Ile Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
        995                 1000                 1005             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1010                 1015                 1020             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ala Ala 
    1025                 1030                 1035             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ser Gln 
    1040                 1045                 1050             


Glu Arg  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Glu Gly Lys 
    1055                 1060                 1065             


Ala Tyr  Phe Pro Arg Glu Gly  Val Phe Val Phe Asn  Gly Thr Ser 
    1070                 1075                 1080             


Trp Phe  Ile Thr Gln Arg Asn  Phe Phe Ser Pro Gln  Ile Ile Thr 
    1085                 1090                 1095             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1100                 1105                 1110             


Ile Ile  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1115                 1120                 1125             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1130                 1135                 1140             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1145                 1150                 1155             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1160                 1165                 1170             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1175                 1180                 1185             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Val Trp Leu  Gly Phe Ile 
    1190                 1195                 1200             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Leu  Leu Cys Cys 
    1205                 1210                 1215             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Ala Cys  Ser Cys Gly 
    1220                 1225                 1230             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1235                 1240                 1245             


Gly Val  Lys Leu His Tyr Thr  
    1250                 1255 


<210>  25
<211>  189
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2

<400>  25

Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr 
1               5                   10                  15      


Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys 
            20                  25                  30          


Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe 
        35                  40                  45              


Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr 
    50                  55                  60                  


Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln 
65                  70                  75                  80  


Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu 
                85                  90                  95      


Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu 
            100                 105                 110         


Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg 
        115                 120                 125             


Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr 
    130                 135                 140                 


Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr 
145                 150                 155                 160 


Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr 
                165                 170                 175     


Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
            180                 185                 


<210>  26
<211>  183
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus

<400>  26

Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro 
1               5                   10                  15      


Ser Val Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp 
            20                  25                  30          


Tyr Ser Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr 
        35                  40                  45              


Gly Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr 
    50                  55                  60                  


Ala Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro 
65                  70                  75                  80  


Gly Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
                85                  90                  95      


Phe Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr 
            100                 105                 110         


Ser Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys 
        115                 120                 125             


Leu Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp 
    130                 135                 140                 


Gly Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn 
145                 150                 155                 160 


Asp Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg 
                165                 170                 175     


Val Val Val Leu Ser Phe Glu 
            180             


<210>  27
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-V100L

<400>  27

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Leu Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  28
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-D61Q

<400>  28

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Gln Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  29
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-G55S

<400>  29

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Ser Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  30
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-S52A

<400>  30

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ala Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  31
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-W52aF

<400>  31

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Phe Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  32
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-W52aH

<400>  32

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser His Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  33
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-V100A

<400>  33

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Ala Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  34
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-W52aH-S56A

<400>  34

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser His Ser Gly Gly Ala Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  35
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-W52aF-S56A

<400>  35

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Phe Ser Gly Gly Ala Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  36
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-MDoptA-T60W amino acid sequence- MDoptB: refers to the 
       second highest variant obtained by the Molecular Dynamics 
       software

<400>  36

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Trp Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  37
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-MDoptA-T57Y

<400>  37

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Tyr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  38
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-MDoptA-T57W

<400>  38

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Trp Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  39
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-MDoptA-Y100fW

<400>  39

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Trp Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  40
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-MDoptA-T57L

<400>  40

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Leu Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  41
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-MDoptA-G96Y

<400>  41

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Tyr Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  42
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-MDoptA-T57I

<400>  42

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Ile Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  43
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-MDoptA-V100I

<400>  43

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Ile Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  44
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-MDoptA-T57H

<400>  44

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser His Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  45
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-MDoptA-Y59W

<400>  45

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Trp Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  46
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-MDoptB-T60F

<400>  46

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Phe Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  47
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-MDoptB-T99V

<400>  47

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Val Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  48
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-MDoptB-K64W

<400>  48

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Trp Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  49
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-MDoptB-V100L

<400>  49

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Leu Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  50
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-MDoptC-F74R

<400>  50

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  51
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-MDoptC-G98P

<400>  51

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Pro Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  52
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-MDoptC-V100L

<400>  52

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Leu Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  53
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-MDoptC-G98I

<400>  53

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Ile Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  54
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-MDoptC-T75R

<400>  54

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Arg Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  55
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-MDoptC-T75F

<400>  55

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Phe Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  56
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-MDoptC-T75N

<400>  56

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Asn Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  57
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-MDoptC-T50P

<400>  57

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Pro Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  58
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-MDoptC-F47H

<400>  58

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu His Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  59
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-MDoptC-T50Q

<400>  59

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gln Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  60
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-MDoptC-T60Y

<400>  60

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Tyr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  61
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH72-MDoptC-T60R

<400>  61

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  62
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of S309 antibody

<400>  62

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Ser Thr 
            20                  25                  30          


Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Asp Thr Ser Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  63
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of S309 antibody

<400>  63

Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Thr Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Thr Thr Gly Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Thr Arg Gly Ala Trp Phe Gly Glu Ser Leu Ile Gly 
            100                 105                 110         


Gly Phe Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455     


<210>  64
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CB6 light chain sequence

<400>  64

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Glu Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  65
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CB6 heavy chain sequence

<400>  65

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Met Asn Thr Leu Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Leu Pro Met Tyr Gly Asp Tyr Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  66
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cov2_wuhan Spike protein RBD, with a deletion of the RBM loop

<400>  66

Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
1               5                   10                  15      


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
            20                  25                  30          


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
        35                  40                  45              


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
    50                  55                  60                  


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Pro Thr Asn Gly 
65                  70                  75                  80  


Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
                85                  90                  95      


<210>  67
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GD-Pangolin Spike protein RBD, with a deletion of the RBM loop

<400>  67

Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
1               5                   10                  15      


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
            20                  25                  30          


Ser Phe Val Val Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
        35                  40                  45              


Thr Gly Arg Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
    50                  55                  60                  


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Pro Thr Asn Gly 
65                  70                  75                  80  


Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
                85                  90                  95      


<210>  68
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RaTG13 Spike protein RBD, with a deletion of the RBM loop

<400>  68

Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
1               5                   10                  15      


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
            20                  25                  30          


Ser Phe Val Ile Thr Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
        35                  40                  45              


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
    50                  55                  60                  


Gly Cys Val Ile Ala Trp Asn Ser Lys His Ile Asp Pro Thr Asp Gly 
65                  70                  75                  80  


Val Gly His Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
                85                  90                  95      


<210>  69
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WIV1 Spike protein RBD, with a deletion of the RBM loop

<400>  69

Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
1               5                   10                  15      


Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp 
            20                  25                  30          


Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln 
        35                  40                  45              


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
    50                  55                  60                  


Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ile Thr Asn Gly 
65                  70                  75                  80  


Ile Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
                85                  90                  95      


<210>  70
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LYRa11 Spike protein RBD, with a deletion of the RBM loop

<400>  70

Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
1               5                   10                  15      


Ser Ala Ile Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp 
            20                  25                  30          


Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln 
        35                  40                  45              


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met 
    50                  55                  60                  


Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Thr Thr Asn Gly 
65                  70                  75                  80  


Ile Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
                85                  90                  95      


<210>  71
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RsSHC014 Spike protein RBD, with a deletion of the RBM loop

<400>  71

Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
1               5                   10                  15      


Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp 
            20                  25                  30          


Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln 
        35                  40                  45              


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Leu 
    50                  55                  60                  


Gly Cys Val Leu Ala Trp Asn Thr Asn Ser Lys Asp Thr Thr Ala Gly 
65                  70                  75                  80  


Val Gly His Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
                85                  90                  95      


<210>  72
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rs7327 Spike protein RBD domain, with a deletion of the RBM loop

<400>  72

Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
1               5                   10                  15      


Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp 
            20                  25                  30          


Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln 
        35                  40                  45              


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met 
    50                  55                  60                  


Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Thr Thr Asn Gly 
65                  70                  75                  80  


Ile Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
                85                  90                  95      


<210>  73
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-1 Spike protein RBD, with a deletion of the RBM loop

<400>  73

Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val 
1               5                   10                  15      


Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp 
            20                  25                  30          


Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln 
        35                  40                  45              


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met 
    50                  55                  60                  


Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Thr Thr Thr Gly 
65                  70                  75                  80  


Ile Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
                85                  90                  95      


<210>  74
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rs4231 Spike protein RBD, with a deletion of the RBM loop

<400>  74

Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
1               5                   10                  15      


Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp 
            20                  25                  30          


Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln 
        35                  40                  45              


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Leu 
    50                  55                  60                  


Gly Cys Val Leu Ala Trp Asn Thr Asn Ser Lys Asp Thr Thr Ala Gly 
65                  70                  75                  80  


Val Gly His Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
                85                  90                  95      


<210>  75
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rs4084 Spike protein RBD, with a deletion of the RBM loop

<400>  75

Ile Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
1               5                   10                  15      


Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp 
            20                  25                  30          


Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln 
        35                  40                  45              


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Leu 
    50                  55                  60                  


Gly Cys Val Leu Ala Trp Asn Thr Asn Ser Lys Asp Thr Thr Ala Gly 
65                  70                  75                  80  


Val Gly His Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
                85                  90                  95      


<210>  76
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rp3 Spike protein RBD, with a deletion of the RBM loop

<400>  76

Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
1               5                   10                  15      


Ser Pro Ser Lys Leu Ile Asp Leu Cys Phe Thr Ser Val Tyr Ala Asp 
            20                  25                  30          


Thr Phe Leu Ile Arg Ser Ser Glu Val Arg Gln Val Ala Pro Gly Glu 
        35                  40                  45              


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
    50                  55                  60                  


Gly Cys Val Ile Ala Trp Asn Thr Ala Lys Gln Asp Pro Ser Val Pro 
65                  70                  75                  80  


Val Ala Tyr Gln Ala Thr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
                85                  90                  95      


<210>  77
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HKU3-1 Spike protein RBD, with a deletion of the RBM loop

<400>  77

Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
1               5                   10                  15      


Ser Pro Ser Lys Leu Ile Asp Leu Cys Phe Thr Ser Val Tyr Ala Asp 
            20                  25                  30          


Thr Phe Leu Ile Arg Ser Ser Glu Val Arg Gln Val Ala Pro Gly Glu 
        35                  40                  45              


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
    50                  55                  60                  


Gly Cys Val Ile Ala Trp Asn Thr Ala Lys His Asp Pro Asn Val Pro 
65                  70                  75                  80  


Val Ala Tyr Gln Ala Thr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
                85                  90                  95      


<210>  78
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZXC21 Spike protein RBD, with a deletion of the RBM loop

<400>  78

Val Phe Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
1               5                   10                  15      


Ser Pro Ser Lys Leu Ile Asp Leu Cys Phe Thr Ser Val Tyr Ala Asp 
            20                  25                  30          


Thr Phe Leu Ile Arg Phe Ser Glu Val Arg Gln Val Ala Pro Gly Gln 
        35                  40                  45              


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
    50                  55                  60                  


Gly Cys Val Ile Ala Trp Asn Thr Ala Lys Gln Asp Pro Asn Val Pro 
65                  70                  75                  80  


Leu Glu Tyr Gln Ala Thr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
                85                  90                  95      


<210>  79
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZC45 Spike protein RBD, with a deletion of the RBM loop

<400>  79

Val Phe Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
1               5                   10                  15      


Ser Pro Ser Lys Leu Ile Asp Leu Cys Phe Thr Ser Val Tyr Ala Asp 
            20                  25                  30          


Thr Phe Leu Ile Arg Phe Ser Glu Val Arg Gln Val Ala Pro Gly Gln 
        35                  40                  45              


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
    50                  55                  60                  


Gly Cys Val Ile Ala Trp Asn Thr Ala Lys Gln Asp Pro Asn Val Pro 
65                  70                  75                  80  


Leu Glu Tyr Gln Ala Thr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
                85                  90                  95      


<210>  80
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rf1 Spike protein RBD, with a deletion of the RBM loop

<400>  80

Val Phe Tyr Asn Ser Thr Ser Phe Ser Thr Phe Asn Cys Tyr Gly Val 
1               5                   10                  15      


Ser Pro Ser Lys Leu Ile Asp Leu Cys Phe Thr Ser Val Tyr Ala Asp 
            20                  25                  30          


Thr Phe Leu Ile Arg Phe Ser Glu Val Arg Gln Val Ala Pro Gly Gln 
        35                  40                  45              


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
    50                  55                  60                  


Gly Cys Val Ile Ala Trp Asn Thr Ala Lys Gln Asp Gln Asn Val Pro 
65                  70                  75                  80  


Leu Glu Tyr Gln Ala Thr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
                85                  90                  95      


<210>  81
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BM48-31 Spike protein RBD, with a deletion of the RBM loop

<400>  81

Val Leu Tyr Asn Ser Ser Ala Ser Phe Ser Thr Phe Gln Cys Tyr Gly 
1               5                   10                  15      


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Ser Ser Val Tyr Ala 
            20                  25                  30          


Asp Tyr Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Ala 
        35                  40                  45              


Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
    50                  55                  60                  


Thr Gly Cys Val Ile Ala Trp Asn Thr Asn Ser Leu Asp Gln Ser Ser 
65                  70                  75                  80  


Gly Ile Gly Phe Gln 
                85  


<210>  82
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  82
ttacaaacat tggccgcaaa                                                   20


<210>  83
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  83
gcgcgacatt ccgaagaa                                                     18


<210>  84
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  84
ccagtaatgt ggacattgcc                                                   20


<210>  85
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  85
catcaacgac cttgtcttca gta                                               23


<210>  86
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  86
gccattcatc cacagttgac a                                                 21


<210>  87
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  87
catggtgctg acagtggagt ct                                                22


<210>  88
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  88
gggaactgtc aaagggtaca g                                                 21


<210>  89
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  89
cccttcctac atcagtccta ct                                                22


<210>  90
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  90
ggccaggtca tcaccatt                                                     18


<210>  91
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  91
gagttgaatg tagtttcgtg gatg                                              24


<210>  92
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH2.50

<400>  92

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Ile 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  93
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH3.17

<400>  93

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Glu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Gly Asp Gly 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Gly Pro Gly Arg Pro Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Val Ser Trp Asn Gly Gly Gly Thr Tyr Phe Ala Glu Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Ala Gly Glu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  94
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH3.77

<400>  94

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ser Ser Gly Arg Ala Phe Gly Asn Gly 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Gly Pro Gly Arg Pro Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Val Ser Trp Asn Gly Gly Gly Thr Tyr Phe Ala Glu Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Ala Gly Glu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  95
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH3.115

<400>  95

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Ile 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Arg Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Gly Thr Tyr Tyr Ala Glu Pro Val 
    50                  55                  60                  


Arg Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Ala Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  96
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH3.144

<400>  96

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Ala Phe Gly Asn Gly 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Arg Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Val Ser Trp Asn Gly Gly Gly Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ala Gly Glu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  97
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH3BE4

<400>  97

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Ala Phe Gly Asn Gly 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Arg Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Val Ser Trp Asn Gly Gly Gly Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ala Gly Glu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  98
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH3.83

<400>  98

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Leu Ser Gly Gly Val Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Leu 
        35                  40                  45              


Ala Ala Ile Thr Phe Asn Ser Asp Ala Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asn Asp Thr Ala Val Tyr Ser Cys 
                85                  90                  95      


Ala Ala Gly Gly Asn His Tyr Asn Pro Gln Tyr Tyr His Asp Tyr Asp 
            100                 105                 110         


Lys Tyr Asp His Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  99
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH3.36

<400>  99

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Val Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Asn Trp Gly Gly Ile Ser Val Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Lys Gly Trp Ser Glu Trp Asp Met Glu Tyr Trp Gly 
            100                 105                 110         


Lys Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  100
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH3.47

<400>  100

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Asn Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Thr Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Glu Asn Asp Val Met Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr Leu Cys 
                85                  90                  95      


Ala Ala Asp Pro Lys Gly Trp Ser Glu Trp Asp Met Asp Tyr Trp Gly 
            100                 105                 110         


Lys Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  101
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH3.55

<400>  101

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Val Ser Gly Arg Thr Asn Asp Asn Tyr 
            20                  25                  30          


Gly Val Gly Trp Phe Arg Gln Val Pro Gly Ala Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Ser Ile Ser Arg Tyr Tyr Lys Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Met Leu Lys Pro Glu Asp Thr Ala Ala Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Ala Gly Trp Ser Glu Phe Gly Met Glu Tyr Trp Gly 
            100                 105                 110         


Lys Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  102
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH3.35

<400>  102

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Glu Val Ser Gly Arg Thr Asn Asp Asn Tyr 
            20                  25                  30          


Gly Val Gly Trp Phe Arg Gln Val Pro Gly Ala Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Ser Ile Ser Arg Tyr Tyr Lys Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Met Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Ala Gly Trp Ser Glu Phe Gly Met Glu Tyr Trp Gly 
            100                 105                 110         


Lys Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  103
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH3.29

<400>  103

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Ser Ser Gly 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Gln Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Gly Leu Ser Ser Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Met Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Asp His Gly Trp Ser Ala Ala Gly Met Asp Tyr Leu Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  104
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH3.38

<400>  104

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Gln Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Met Phe Trp Ser Gly Leu Pro Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Thr Asp Asp Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ser Arg Gly Trp Ser Asp Val Gly Gly Met Asp Tyr Trp 
            100                 105                 110         


Gly Lys Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  105
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH3.149

<400>  105

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Thr Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Phe Gly Ala Pro Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ser Lys Gly Trp Asp Pro Gln Asp Met Asp Tyr Trp Gly 
            100                 105                 110         


Lys Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  106
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH3.39

<400>  106

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Ile Thr Leu Gly Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Glu Ile 
        35                  40                  45              


Ser Cys Ile Ser Ser Ile Asp Gly Ser Ile Tyr Tyr Thr Asp Ser Ala 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu His Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Ala Ile Gly Tyr His Thr Tyr Arg Thr Asp Thr Pro Leu Tyr 
            100                 105                 110         


Thr His Ser Cys Arg Glu Asn Ser Phe Pro Thr Trp Gly Arg Gly Thr 
        115                 120                 125             


Gln Val Thr Val Ser Ser 
    130                 


<210>  107
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH3.89

<400>  107

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Glu Val Pro Gly Lys Glu Arg Glu Gly Leu 
        35                  40                  45              


Ser Arg Ile Asp Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Ile Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Pro Ile Ile Gln Gly Arg Asn Trp Tyr Trp Thr Gly Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  108
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH3.141

<400>  108

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Val Ser Gly Glu Leu Phe Ser Ile Asn 
            20                  25                  30          


Gly Val Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Glu Gly Gly Asn Thr Asn Tyr Val Asp Asn Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Asn Leu Ser Phe Trp Ser Arg Glu Tyr Glu Tyr Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  109
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH3.151

<400>  109

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Ser Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Gly Cys Ile Ser Ser Ser Asp Asp Ser Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr His Cys 
                85                  90                  95      


Ala Thr Asp Trp Leu Arg Leu Cys Thr Ile Val Ser Gly Thr Gln Val 
            100                 105                 110         


Pro Pro Tyr Asp Val Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  110
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH3BD9

<400>  110

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Pro Cys Ala Ala Ser Gly Phe Thr Leu Leu Asp 
            20                  25                  30          


Arg Tyr Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Gly Val Ser Cys Ile Ser Ser Ser Asp Asp Ser Thr Tyr Tyr Ala Arg 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Thr Asp Trp Leu Arg Leu Cys Thr Val Val Ala Asn Thr 
            100                 105                 110         


Glu Val Pro Pro Tyr Asp Leu Trp Gly Pro Gln Gly Thr Gln Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  111
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  111

Ser Ile Ala Met Gly 
1               5   


<210>  112
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  112

Asp Gly Ala Val Gly 
1               5   


<210>  113
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  113

Asn Gly Ala Val Gly 
1               5   


<210>  114
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  114

Asp Ile Ala Met Gly 
1               5   


<210>  115
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  115

Thr Tyr Ala Met Ala 
1               5   


<210>  116
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  116

Asn Tyr Gly Val Gly 
1               5   


<210>  117
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  117

Ser Gly Gly Met Gly 
1               5   


<210>  118
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  118

Asn Tyr Ala Met Ala 
1               5   


<210>  119
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  119

Ser Tyr Ala Leu Gly 
1               5   


<210>  120
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  120

Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  121
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  121

Thr Val Ser Trp Asn Gly Gly Gly Thr Tyr Phe Ala Glu Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  122
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  122

Thr Val Ser Trp Asn Gly Gly Gly Thr Tyr Tyr Ala Glu Pro Val Arg 
1               5                   10                  15      


Gly 
    


<210>  123
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  123

Thr Val Ser Trp Asn Gly Gly Gly Thr Tyr Tyr Ala Glu Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  124
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  124

Ala Ile Thr Phe Asn Ser Asp Ala Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  125
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  125

Ala Ile Asn Trp Gly Gly Ile Ser Val Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  126
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  126

Ala Ile Ser Glu Asn Asp Val Met Arg Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  127
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  127

Ala Ile Arg Trp Ser Ser Ile Ser Arg Tyr Tyr Lys Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  128
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  128

Gly Ile Gly Trp Ala Gly Leu Ser Ser Tyr Tyr Leu Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  129
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  129

Ala Met Phe Trp Ser Gly Leu Pro Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  130
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  130

Ala Ile Asn Trp Phe Gly Ala Pro Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  131
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  131

Ala Gly Glu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr Glu Tyr 
1               5                   10                  15      


<210>  132
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  132

Ala Gly Ala Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr Asp Tyr 
1               5                   10                  15      


<210>  133
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  133

Ala Gly Glu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr Asp Tyr 
1               5                   10                  15      


<210>  134
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  134

Gly Gly Asn His Tyr Asn Pro Gln Tyr Tyr His Asp Tyr Asp Lys Tyr 
1               5                   10                  15      


Asp His 
        


<210>  135
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  135

Asp Pro Lys Gly Trp Ser Glu Trp Asp Met Glu Tyr 
1               5                   10          


<210>  136
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  136

Asp Pro Lys Gly Trp Ser Glu Trp Asp Met Asp Tyr 
1               5                   10          


<210>  137
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  137

Asp Pro Ala Gly Trp Ser Glu Phe Gly Met Glu Tyr 
1               5                   10          


<210>  138
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  138

Asp Asp His Gly Trp Ser Ala Ala Gly Met Asp Tyr 
1               5                   10          


<210>  139
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  139

Asp Ser Arg Gly Trp Ser Asp Val Gly Gly Met Asp Tyr 
1               5                   10              


<210>  140
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  140

Asp Ser Lys Gly Trp Asp Pro Gln Asp Met Asp Tyr 
1               5                   10          


<210>  141
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of VHH-72- S52A-S56A mutant amino acid sequence

<400>  141

Thr Ile Ala Trp Ser Gly Gly Ala Thr Tyr Tyr Thr Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  142
<211>  20
<212>  PRT
<213>  SARS-CoV

<400>  142

Ala Thr Ser Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His 
1               5                   10                  15      


Gly Lys Leu Arg 
            20  


<210>  143
<211>  20
<212>  PRT
<213>  SARS-CoV

<400>  143

Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val Val Val Leu 
1               5                   10                  15      


Ser Phe Glu Leu 
            20  


<210>  144
<211>  11
<212>  PRT
<213>  SARS-CoV


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  Xaa can be any naturally occurring amino acid

<400>  144

Thr Xaa Thr Gly Xaa Xaa Xaa Xaa Xaa Tyr Arg 
1               5                   10      


<210>  145
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  145

Gly Gly Gly Gly Ser 
1               5   


<210>  146
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  146

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10          


<210>  147
<211>  183
<212>  PRT
<213>  SARS-CoV

<400>  147

Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro 
1               5                   10                  15      


Ser Val Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp 
            20                  25                  30          


Tyr Ser Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr 
        35                  40                  45              


Gly Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr 
    50                  55                  60                  


Ala Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro 
65                  70                  75                  80  


Gly Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
                85                  90                  95      


Phe Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr 
            100                 105                 110         


Ser Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys 
        115                 120                 125             


Leu Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp 
    130                 135                 140                 


Gly Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn 
145                 150                 155                 160 


Asp Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg 
                165                 170                 175     


Val Val Val Leu Ser Phe Glu 
            180             


<210>  148
<211>  184
<212>  PRT
<213>  2019-nCoV

<400>  148

Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
1               5                   10                  15      


Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp 
            20                  25                  30          


Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
        35                  40                  45              


Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
    50                  55                  60                  


Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro 
65                  70                  75                  80  


Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
                85                  90                  95      


Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
            100                 105                 110         


Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn 
        115                 120                 125             


Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
    130                 135                 140                 


Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu 
145                 150                 155                 160 


Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr 
                165                 170                 175     


Arg Val Val Val Leu Ser Phe Glu 
            180                 


<210>  149
<211>  201
<212>  PRT
<213>  2019-nCoV

<400>  149

Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Lys Lys Ser Thr 
        195                 200     


