                         SEQUENCE LISTING

<110>  THE UNIVERSITY OF BATH
 
<120>  DIMERIZATION ASSAY

<130>  007867575

<140>  PCT/EP2021/052568
<141>  2021-02-03

<150>  GB 2001491.6
<151>  2020-02-04

<160>  97    

<170>  PatentIn version 3.5

<210>  1
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild-type murine dihydrofolate reductase

<400>  1

Met Val Arg Pro Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Lys Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Arg Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Asp Arg Ile Asn Ile Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Arg Gly Ala His Phe Leu Ala Lys Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Arg Leu Ile Glu Gln Pro Glu Leu Ala Ser Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Gln Glu Ala Met Asn Gln 
        115                 120                 125             


Pro Gly His Leu Arg Leu Phe Val Thr Arg Ile Met Gln Glu Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Gly Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Glu Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Lys Asp 
            180                 185         


<210>  2
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  engineered murine dihydrofolate reductase

<400>  2

Met Val Arg Pro Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Ser 
            20                  25                  30          


Lys Tyr Phe Gln Arg Met Thr Gln Thr Asp Ser Val Glu Ser Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Arg Lys Thr Trp Phe Ser Ile Pro Glu Ser 
    50                  55                  60                  


Asn Arg Pro Leu Lys Asp Arg Ile Asn Ile Val Leu Ser Gln Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Arg Gly Ala His Phe Leu Ala Lys Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Arg Leu Ile Glu Ser Pro Glu Leu Ala Ser Lys Val Asp Ser 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Gln Glu Ala Met Thr Gln 
        115                 120                 125             


Pro Gly His Leu Arg Leu Phe Val Thr Gln Ile Met Gln Glu Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Ser Gly Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Ser Pro Gly Val Leu Ser Gln Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Lys Asp 
            180                 185         


<210>  3
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild-type human dihydrofolate reductase

<400>  3

Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210>  4
<211>  564
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  engineered murine dihydrofolate reductase

<400>  4
atggttcgac cattgaactg catcgtcgcc gtgagtcaga atatggggat tggcaagaac       60

ggagacctac cctggcctcc gctcaggaat gagtcaaagt acttccaaag aatgactcag      120

actgactcag ttgagtcaaa acagaatctg gtgattatgg gtaggaaaac ctggttctcc      180

attcctgagt caaatcgacc tttaaaggac agaattaata tagttctgag tcaagaactc      240

aaagaaccac cacgaggagc tcattttctt gccaaaagtt tggatgatgc cttaagactt      300

attgagtcac cggaattggc gagcaaagtt gactcagttt ggatcgtcgg aggcagttct      360

gtttaccagg aagccatgac tcaaccaggc caccttagac tctttgtgac tcagatcatg      420

caggaatttg agtcagacac gtttttccca gaaattgact cagggaaata taaacttctc      480

cctgagtcac caggcgtcct gagtcaggtc caggaggaaa aaggcatcaa gtataagttt      540

gaagtctacg agaagaaaga ctaa                                             564


<210>  5
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPA response elements (TRE)

<400>  5
tgactca                                                                  7


<210>  6
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPA response elements (TRE)

<400>  6
tgagtca                                                                  7


<210>  7
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ebox response elements

<400>  7
cacgtg                                                                   6


<210>  8
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ebox response elements

<400>  8
cacatg                                                                   6


<210>  9
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C/EBP protein response element

<400>  9
attgcgcaat                                                              10


<210>  10
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cAMP response element (CRE)

<400>  10
tgacgtca                                                                 8


<210>  11
<211>  567
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide encoding engineered murine dihydrofolate reductase
       including restriction enzyme sites

<400>  11
gctagcgttc gaccattgaa ctgcatcgtc gccgtgagtc agaatatggg gattggcaag       60

aacggagacc taccctggcc tccgctcagg aatgagtcaa agtacttcca aagaatgact      120

cagactgact cagttgagtc aaaacagaat ctggtgatta tgggtaggaa aacctggttc      180

tccattcctg agtcaaatcg acctttaaag gacagaatta atatagttct gagtcaagaa      240

ctcaaagaac caccacgagg agctcatttt cttgccaaaa gtttggatga tgccttaaga      300

cttattgagt caccggaatt ggcgagcaaa gttgactcag tttggatcgt cggaggcagt      360

tctgtttacc aggaagccat gactcaacca ggccacctta gactctttgt gactcagatc      420

atgcaggaat ttgagtcaga cacgtttttc ccagaaattg actcagggaa atataaactt      480

ctccctgagt caccaggcgt cctgagtcag gtccaggagg aaaaaggcat caagtataag      540

tttgaagtct acgagaagaa agactaa                                          567


<210>  12
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example reading frames

<400>  12
tgactca                                                                  7


<210>  13
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example reading frames

<400>  13
tgactca                                                                  7


<210>  14
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example reading frames

<400>  14
tgactca                                                                  7


<210>  15
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  example reading frame 3

<400>  15

Phe Ser Tyr Cys Leu Pro His Arg Ile Thr Asn Val Ala Asp Gly 
1               5                   10                  15  


<210>  16
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example codon triplets containing TREs

<400>  16
gtgagtcag                                                                9


<210>  17
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example codon triplets containing TREs

<400>  17
aatgagtca                                                                9


<210>  18
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example codon triplets containing TREs

<400>  18
atgactcag                                                                9


<210>  19
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example codon triplets containing TREs

<400>  19
actgactca                                                                9


<210>  20
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example codon triplets containing TREs

<400>  20
gttgagtca                                                                9


<210>  21
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example codon triplets containing TREs

<400>  21
cctgagtca                                                                9


<210>  22
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example codon triplets containing TREs

<400>  22
ctgagtcaa                                                                9


<210>  23
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example codon triplets containing TREs

<400>  23
attgagtca                                                                9


<210>  24
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example codon triplets containing TREs

<400>  24
gttgactca                                                                9


<210>  25
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example codon triplets containing TREs

<400>  25
atgactcaa                                                                9


<210>  26
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example codon triplets containing TREs

<400>  26
gtgactcag                                                                9


<210>  27
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example codon triplets containing TREs

<400>  27
tttgagtca                                                                9


<210>  28
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example codon triplets containing TREs

<400>  28
attgactca                                                                9


<210>  29
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example codon triplets containing TREs

<400>  29
cctgagtca                                                                9


<210>  30
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example codon triplets containing TREs

<400>  30
ctgagtcag                                                                9


<210>  31
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  engineered murine dihydrofolate reductase used during design 
       process

<400>  31

Ala Ser Val Arg Pro Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met 
1               5                   10                  15      


Gly Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu 
            20                  25                  30          


Ser Lys Tyr Phe Gln Arg Met Thr Gln Thr Asp Ser Val Glu Ser Lys 
        35                  40                  45              


Gln Asn Leu Val Ile Met Gly Arg Lys Thr Trp Phe Ser Ile Pro Glu 
    50                  55                  60                  


Ser Asn Arg Pro Leu Lys Asp Arg Ile Asn Ile Val Leu Ser Gln Glu 
65                  70                  75                  80  


Leu Lys Glu Pro Pro Arg Gly Ala His Phe Leu Ala Lys Ser Leu Asp 
                85                  90                  95      


Asp Ala Leu Arg Leu Ile Glu Ser Pro Glu Leu Ala Ser Lys Val Asp 
            100                 105                 110         


Ser Val Trp Ile Val Gly Gly Ser Ser Val Tyr Gln Glu Ala Met Thr 
        115                 120                 125             


Gln Pro Gly His Leu Arg Leu Phe Val Thr Gln Ile Met Gln Glu Phe 
    130                 135                 140                 


Glu Ser Asp Thr Phe Phe Pro Glu Ile Asp Ser Gly Lys Tyr Lys Leu 
145                 150                 155                 160 


Leu Pro Glu Ser Pro Gly Val Leu Ser Gln Val Gln Glu Glu Lys Gly 
                165                 170                 175     


Ile Lys Tyr Lys Phe Glu Val Tyr Glu Lys Lys Asp Ala 
            180                 185                 


<210>  32
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Maf recognition elements (MAREs)


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n = G or C

<400>  32
tgctgantca gca                                                          13


<210>  33
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Maf recognition elements (MAREs)


<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  position 7 and 8 together are either GC or CG

<400>  33
tgctganntc agca                                                         14


<210>  34
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Par/CREB-2/PAP binding site

<400>  34
ttacgtaa                                                                 8


<210>  35
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  binding site

<400>  35
ggccaatct                                                                9


<210>  36
<211>  570
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an exemplary murine dihydrofolate reductase gene engineered to 
       include CRE binding sites

<400>  36
atggttcgac cattgaactg catcgtcgcc gtgtcccaaa atatggggat tggcaagaac       60

ggagacctac cctggcctcc gctcaggaac gagttcaagt acttccaaag aatgacgtca      120

acctcttcag tggaaggtaa acagaatctg gtgattatgg gtaggaaaac ctggttctcc      180

attcctgaga agaatcgacc tttaaaggac agaattaata tagtgacgtc aagagaactc      240

aaagaaccac cacgaggagc tcattttctt gccaaaagtt tggatgatgc cttaagactt      300

attgaacaac cggaattgac gtcaaaagta gacatggttt ggatcgtcgg aggcagttct      360

gtttaccagg aagccatgaa tcaaccaggc caccttagac tctttgtgac gtcaatcatg      420

caggaatttg aaagtgacac gtttttccca gaaattgatt tggggaaata taaacttctc      480

ccagaatacc caggcgtgac gtcagaggtc caggaggaaa aaggcatcaa gtataagttt      540

gaagtctacg agaagaaaga ctaagcttaa                                       570


<210>  37
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  an exemplary murine dihydrofolate reductase engineered to include
       CRE binding sites

<400>  37

Met Val Arg Pro Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Lys Tyr Phe Gln Arg Met Thr Ser Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Arg Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Asp Arg Ile Asn Ile Val Thr Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Arg Gly Ala His Phe Leu Ala Lys Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Arg Leu Ile Glu Gln Pro Glu Leu Thr Ser Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Gln Glu Ala Met Asn Gln 
        115                 120                 125             


Pro Gly His Leu Arg Leu Phe Val Thr Ser Ile Met Gln Glu Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Gly Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Thr Ser Glu Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Lys Asp 
            180                 185         


<210>  38
<211>  570
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an exemplary murine dihydrofolate reductase gene engineered to 
       include CCAAT binding sites

<400>  38
atggttcgac cattgaactg catcgtcgcc gtgtcccaaa atatggggat tggcaagaac       60

ggagacctac cctggcctcc attgcgcaat gagttcaagt acttccaaag aatgaccaca      120

acctcttcag tggaaggtaa acagaatctg gtgattatgg gtaggaaaac ctggttctcc      180

attcctgaga agaatcgacc attgcgcaat agaattaata tagttctcag tagagaattg      240

cgcaatccac cacgaggagc tcattttatt gcgcaatcct tggatgatgc attgcgcaat      300

attgaacaac cggaattggc gagcaaagta gacatggttt ggatcgtcgg aggcagttct      360

gtttaccagg aagccatgaa tcaaccaggc caccttagac tctttgtgac aaggatcatg      420

caggaatttg aaagtgacac gtttttccca gaaattgatt tggggaaata taaacttctc      480

ccagaatacc caggcgtcct ctctgaattg cgcaatgaaa aaggcatcaa gtataagttt      540

gaagtctacg agaagaaaga ctaagcttaa                                       570


<210>  39
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  an exemplary murine dihydrofolate reductase engineered to include
       CCAAT binding sites

<400>  39

Met Val Arg Pro Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Lys Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Arg Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Arg Asn Arg Ile Asn Ile Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Arg Asn Pro Pro Arg Gly Ala His Phe Ile Ala Gln Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Arg Asn Ile Glu Gln Pro Glu Leu Ala Ser Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Gln Glu Ala Met Asn Gln 
        115                 120                 125             


Pro Gly His Leu Arg Leu Phe Val Thr Arg Ile Met Gln Glu Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Gly Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Glu Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Lys Asp 
            180                 185         


<210>  40
<211>  570
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an exemplary murine dihydrofolate reductase gene engineered to 
       include Eboxes

<400>  40
atggttcgac cattgaactg catcgtcgcc gtgtcccaaa atatggggat tggcaagaac       60

ggagacctac cctggcctcc gctcaggaac gagttcaagt acttccaaag aatgaccaca      120

acctcttcag tggaaggtaa acagaatctg gtgattatgg gtaggcgcac gtggttctcc      180

attcctgaga agaatcgacc tttaaaggac agaattaata tagttctctc acgtgaactc      240

aaagaaccac cacgtggagc tcacgtgctt gccaaatcac tggatgatgc attaagactt      300

attgaacaac cggaattggc gtcacgtgta gacatggttt ggatcgtcgg aggcagttct      360

gtttaccagg aagccatgaa tcaaccaggc cacgtgagac tctttgtgac acgtgtcatg      420

caggaatttg aaagtgacac gtttttccca gaaattgatt tggggaaata taaacttctc      480

ccagaatacc caggcgtcct ctcacgtgtc caggaggaaa aaggcatcaa gtataagttt      540

gaagtctacg agaagaaaga ctaagcttaa                                       570


<210>  41
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  an exemplary murine dihydrofolate reductase engineered to include
       Eboxes

<400>  41

Met Val Arg Pro Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Lys Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Arg Arg Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Asp Arg Ile Asn Ile Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Arg Gly Ala His Val Leu Ala Lys Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Arg Leu Ile Glu Gln Pro Glu Leu Ala Ser Arg Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Gln Glu Ala Met Asn Gln 
        115                 120                 125             


Pro Gly His Val Arg Leu Phe Val Thr Arg Val Met Gln Glu Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Gly Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Arg Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Lys Asp 
            180                 185         


<210>  42
<211>  3553
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p300-mDHFR plasmid

<400>  42
ctcgagaaat cataaaaaat ttatttgctt tgtgagcgga taacaattat aatagattca       60

attgtgagcg gataacaatt tcacacagaa ttcattaaag aggagaaatt aagcatgcac      120

catcaccatc accatgctag cgttcgacca ttgaactgca tcgtcgccgt gagtcagaat      180

atggggattg gcaagaacgg agacctaccc tggcctccgc tcaggaatga gtcaaagtac      240

ttccaaagaa tgactcagac tgactcagtt gagtcaaaac agaatctggt gattatgggt      300

aggaaaacct ggttctccat tcctgagtca aatcgacctt taaaggacag aattaatata      360

gttctgagtc aagaactcaa agaaccacca cgaggagctc attttcttgc caaaagtttg      420

gatgatgcct taagacttat tgagtcaccg gaattggcga gcaaagttga ctcagtttgg      480

atcgtcggag gcagttctgt ttaccaggaa gccatgactc aaccaggcca ccttagactc      540

tttgtgactc agatcatgca ggaatttgag tcagacacgt ttttcccaga aattgactca      600

gggaaatata aacttctccc tgagtcacca ggcgtcctga gtcaggtcca ggaggaaaaa      660

ggcatcaagt ataagtttga agtctacgag aagaaagact aagcttaatt agctgagctt      720

ggactcctgt tgatagatcc agtaatgacc tcagaactcc atctggattt gttcagaacg      780

ctcggttgcc gccgggcgtt ttttattggt gagaatccaa gctagtttgg gaggttccaa      840

ctttcaccat aatgaaataa gatcactacc gggcgtattt tttgagttat cgagattttc      900

aggagctaag gaagctaaaa tggagaaaaa aatcactgga tataccaccg ttgatatatc      960

ccaatggcat cgtaaagaac attttgaggc atttcagtca gttgctcaat gtacctataa     1020

ccagaccgtt cagctggata ttacggcctt tttaaagacc gtaaagaaaa ataagcacaa     1080

gttttatccg gcctttattc acattcttgc ccgcctgatg aatgctcatc cggagttccg     1140

tatggcaatg aaagacggtg agctggtgat atgggatagt gttcaccctt gttacaccgt     1200

tttccatgag caaactgaaa cgttttcatc gctctggagt gaataccacg acgatttccg     1260

gcagtttcta cacatatatt cgcaagatgt ggcgtgttac ggtgaaaacc tggcctattt     1320

ccctaaaggg tttattgaga atatgttttt cgtctcagcc aatccctggg tgagtttcac     1380

cagttttgat ttaaacgtgg ccaatatgga caacttcttc gcccccgttt tcaccatggg     1440

caaatattat acgcaaggcg acaaggtgct gatgccgctg gcgattcagg ttcatcatgc     1500

cgtttgtgat ggcttccatg tcggcagaat gcttaatgaa ttacaacagt actgcgatga     1560

gtggcagggc ggggcgtaat ttttttaagg cagttattgg tgcccttaaa cgcctggggt     1620

aatgactctc tagcttgagg catcaaataa aacgaaaggc tcagtcgaaa gactgggcct     1680

ttcgttttat ctgttgtttg tcggtgaacg ctctcctgag taggacaaat ccgccctcta     1740

gagctgcctc gcgcgtttcg gtgatgacgg tgaaaacctc tgacacatgc agctcccgga     1800

gacggtcaca gcttgtctgt aagcggatgc cgggagcaga caagcccgtc agggcgcgtc     1860

agcgggtgtt ggcgggtgtc ggggcgcagc catgacccag tcacgtagcg atagcggagt     1920

gtatactggc ttaactatgc ggcatcagag cagattgtac tgagagtgca ccatatgcgg     1980

tgtgaaatac cgcacagatg cgtaaggaga aaataccgca tcaggcgctc ttccgcttcc     2040

tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca     2100

aaggcggtaa tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca     2160

aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg     2220

ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg     2280

acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt     2340

ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt     2400

tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc     2460

tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt     2520

gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt     2580

agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc     2640

tacactagaa ggacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa     2700

agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt     2760

tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct     2820

acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta     2880

tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa     2940

agtatatatg agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc     3000

tcagcgatct gtctatttcg ttcatccata gttgcctgac tccccgtcgt gtagataact     3060

acgatacggg agggcttacc atctggcccc agtgctgcaa tgataccgcg agacccacgc     3120

tcaccggctc cagatttatc agcaataaac cagccagccg cgttcttcgg ggcgaaaact     3180

ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg cacccaactg     3240

atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa     3300

tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac tcttcctttt     3360

tcaatattat tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaatg     3420

tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag tgccacctga     3480

cgtctaagaa accattatta tcatgacatt aacctataaa aataggcgta tcacgaggcc     3540

ctttcgtctt cac                                                        3553


<210>  43
<211>  3600
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p230d-basic-cJun plasmid

<400>  43
ctcgagaaat cataaaaaat ttatttgctt tgtgagcgga taacaattat aatagattca       60

attgtgagcg gataacaatt tcacacagaa ttcattaaag aggagaaatt aagcatgcgc      120

attaaagccg aacgcaaacg gatgcgcaac cgcatcgcag cctccaagtg ccgcaaacgc      180

aaattggagc gcatcgcccg cttggaagaa aaggtgaaaa ccctgaaagc acagaactat      240

gagctggcct ccaccgccaa catgttgcgc gaacaggtgg cccagctcgg cgcgcctcat      300

caccatcacc atcactgata aagcgcgcct tgataagctt aattagctga gcttggactc      360

ctgttgatag atccagtaat gacctcagaa ctccatctgg atttgttcag aacgctcggt      420

tgccgccggg cgttttttat tggtgagaat ccaggcgaga ttttcaggag ctaaggaagc      480

taaaatggag aaaaaaatca ctggatatac caccgttgat atatcccaat ggcatcgtaa      540

agaacatttt gaggcatttc agtcagttgc tcaatgtacc tataaccaga ccgttcagct      600

ggatattacg gcctttttaa agaccgtaaa gaaaaataag cacaagtttt atccggcctt      660

tattcacatt cttgcccgcc tgatgaatgc tcatccggaa tttcgtatgg caatgaaaga      720

cggtgagctg gtgatatggg atagtgttca cccttgttac accgttttcc atgagcaaac      780

tgaaacgttt tcatcgctct ggagtgaata ccacgacgat ttccggcagt ttctacacat      840

atattcgcaa gatgtggcgt gttacggtga aaacctggcc tatttcccta aagggtttat      900

tgagaatatg tttttcgtct cagccaatcc ctgggtgagt ttcaccagtt ttgatttaaa      960

cgtggccaat atggacaact tcttcgcccc cgttttcacc atgggcaaat attatacgca     1020

aggcgacaag gtgctgatgc cgctggcgat tcaggttcat catgccgttt gtgatggctt     1080

ccatgtcggc agaatgctta atgaattaca acagtactgc gatgagtggc agggcggggc     1140

gtaatttttt taaggcagtt attggtgccc ttaaacgcct ggggtaatga ctctctagct     1200

tgaggcatca aataaaacga aaggctcagt cgaaagactg ggcctttcgt tttatctgtt     1260

gtttgtcggt gaacgctctc ctgagtagga caaatccgcc ctctagagct gcctcgcgcg     1320

tttcggtgat gacggtgaaa acctctgaca catgcagctc ccggagacgg tcacagcttg     1380

tctgtaagcg gatgccggga gcagacaagc ccgtcagggc gcgtcagcgg gtgttggcgg     1440

gtgtcggggc gcagccatga cccagtcacg tagcgatagc ggagtgtata ctggcttaac     1500

tatgcggcat cagagcagat tgtactgaga gtgcaccata tgcggtgtga aataccgcac     1560

agatgcgtaa ggagaaaata ccgcatcagg cgctcttccg cttcctcgct cactgactcg     1620

ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg     1680

ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag     1740

gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac     1800

gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga     1860

taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt     1920

accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc     1980

tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc     2040

cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta     2100

agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat     2160

gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac tagaaggaca     2220

gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct     2280

tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt     2340

acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct     2400

cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc     2460

acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa     2520

acttggtctg acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta     2580

tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc     2640

ttaccatctg gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat     2700

ttatcagcaa taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta     2760

tccgcctcca tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt     2820

aatagtttgc gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt     2880

ggtatggctt cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg     2940

ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc     3000

gcagtgttat cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc     3060

gtaagatgct tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg     3120

cggcgaccga gttgctcttg cccggcgtca atacgggata ataccgcgcc acatagcaga     3180

actttaaaag tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta     3240

ccgctgttga gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct     3300

tttactttca ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag     3360

ggaataaggg cgacacggaa atgttgaata ctcatactct tcctttttca atattattga     3420

agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat     3480

aaacaaatag gggttccgcg cacatttccc cgaaaagtgc cacctgacgt ctaagaaacc     3540

attattatca tgacattaac ctataaaaat aggcgtatca cgaggccctt tcgtcttcac     3600


<210>  44
<211>  3740
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pREP4 expressing the lac repressor

<400>  44
aagcttcacg ctgccgcaag cactcagggc gcaagggctg ctaaaggaag cggaacacgt       60

agaaagccag tccgcagaaa cggtgctgac cccggatgaa tgtcagctac tgggctatct      120

ggacaaggga aaacgcaagc gcaaagagaa agcaggtagc ttgcagtggg cttacatggc      180

gatagctaga ctgggcggtt ttatggacag caagcgaacc ggaattgcca gctggggcgc      240

cctctggtaa ggttgggaag ccctgcaaag taaactggat ggctttcttg ccgccaagga      300

tctgatggcg caggggatca agatctgatc aagagacagg atgacggtcg tttcgcatgc      360

ttgaacaaga tggattgcac gcaggttctc cggccgcttg ggtggagagg ctattcggct      420

atgactgggc acaacagaca atcggctgct ctgatgccgc cgtgttccgg ctgtcagcgc      480

aggggcgccc ggttcttttt gtcaagaccg acctgtccgg tgccctgaat gaactgcagg      540

acgaggcagc gcggctatcg tggctggcca cgacgggcgt tccttgcgca gctgtgctcg      600

acgttgtcac tgaagcggga agggactggc tgctattggg cgaagtgccg gggcaggatc      660

tcctgtcatc tcaccttgct cctgccgaga aagtatccat catggctgat gcaatgcggc      720

ggctgcatac gcttgatccg gctacctgcc cattcgacca ccaagcgaaa catcgcatcg      780

agcgagcacg tactcggatg gaagccggtc ttgtcgatca ggatgatctg gacgaagagc      840

atcaggggct cgcgccagcc gaactgttcg ccaggctcaa ggcgcgcatg cccgacggcg      900

aggatctcgt cgtgacccat ggcgatgcct gcttgccgaa tatcatggtg gaaaatggcc      960

gcttttctgg attcatcgac tgtggccggc tgggtgtggc ggaccgctat caggacatag     1020

cgttggctac ccgtgatatt gctgaagagc ttggcggcga atgggctgac cgcttcctcg     1080

tgctttacgg tatcgccgct cccgattcgc agcgcatcgc cttctatcgc cttcttgacg     1140

agttcttctg agcgggactc tggggttcga aatgaccgac caagcgacgc ccaacctgcc     1200

atcacgagat ttcgattcca ccgccgcctt ctatgaaagg ttgggcttcg gaatcgtttt     1260

ccgggacgcc ggctggatga tcctccagcg cggggatctc atgctggagt tcttcgccca     1320

ccccgggctc gatcccctcg cgagttggtt cagctgctgc ctgaggctgg acgacctcgc     1380

ggagttctac cggcagtgca aatccgtcgg catccaggaa accagcagcg gctatccgcg     1440

catccatgcc cccgaactgc aggagtgggg aggcacgatg gccgctttgg tcgacaattc     1500

gcgctaactt acattaattg cgttgcgctc actgcccgct ttccagtcgg gaaacctgtc     1560

gtgccagctg cattaatgaa tcggccaacg cgcggggaga ggcggtttgc gtattgggcg     1620

ccagggtggt ttttcttttc accagtgaga cgggcaacag ctgattgccc ttcaccgcct     1680

ggccctgaga gagttgcagc aagcggtcca cgctggtttg ccccagcagg cgaaaatcct     1740

gtttgatggt ggttaacggc gggatataac atgagctgtc ttcggtatcg tcgtatccca     1800

ctaccgagat atccgcacca acgcgcagcc cggactcggt aatggcgcgc attgcgccca     1860

gcgccatctg atcgttggca accagcatcg cagtgggaac gatgccctca ttcagcattt     1920

gcatggtttg ttgaaaaccg gacatggcac tccagtcgcc ttcccgttcc gctatcggct     1980

gaatttgatt gcgagtgaga tatttatgcc agccagccag acgcagacgc gccgagacag     2040

aacttaatgg gcccgctaac agcgcgattt gctggtgacc caatgcgacc agatgctcca     2100

cgcccagtcg cgtaccgtct tcatgggaga aaataatact gttgatgggt gtctggtcag     2160

agacatcaag aaataacgcc ggaacattag tgcaggcagc ttccacagca atggcatcct     2220

ggtcatccag cggatagtta atgatcagcc cactgacgcg ttgcgcgaga agattgtgca     2280

ccgccgcttt acaggcttcg acgccgcttc gttctaccat cgacaccacc acgctggcac     2340

ccagttgatc ggcgcgagat ttaatcgccg cgacaatttg cgacggcgcg tgcagggcca     2400

gactggaggt ggcaacgcca atcagcaacg actgtttgcc cgccagttgt tgtgccacgc     2460

ggttgggaat gtaattcagc tccgccatcg ccgcttccac tttttcccgc gttttcgcag     2520

aaacgtggct ggcctggttc accacgcggg aaacggtctg ataagagaca ccggcatact     2580

ctgcgacatc gtataacgtt actggtttca cattcaccac cctgaattga ctctcttccg     2640

ggcgctatca tgccataccg cgaaaggttt tgcgccattc gatggtgtca acgtaaatgc     2700

atgccgcttc gccttcgcgc gcgaattgtc gaccctgtcc ctcctgttca gctactgacg     2760

gggtggtgcg taacggcaaa agcaccgccg gacatcagcg ctagcggagt gtatactggc     2820

ttactatgtt ggcactgatg agggtgtcag tgaagtgctt catgtggcag gagaaaaaag     2880

gctgcaccgg tgcgtcagca gaatatgtga tacaggatat attccgcttc ctcgctcact     2940

gactcgctac gctcggtcgt tcgactgcgg cgagcggaaa tggcttacga acggggcgga     3000

gatttcctgg aagatgccag gaagatactt aacagggaag tgagagggcc gcggcaaagc     3060

cgtttttcca taggctccgc ccccctgaca agcatcacga aatctgacgc tcaaatcagt     3120

ggtggcgaaa cccgacagga ctataaagat accaggcgtt tcccctggcg gctccctcgt     3180

gcgctctcct gttcctgcct ttcggtttac cggtgtcatt ccgctgttat ggccgcgttt     3240

gtctcattcc acgcctgaca ctcagttccg ggtaggcagt tcgctccaag ctggactgta     3300

tgcacgaacc ccccgttcag tccgaccgct gcgccttatc cggtaactat cgtcttgagt     3360

ccaacccgga aagacatgca aaagcaccac tggcagcagc cactggtaat tgatttagag     3420

gagttagtct tgaagtcatg cgccggttaa ggctaaactg aaaggacaag ttttggtgac     3480

tgcgctcctc caagccagtt acctcggttc aaagagttgg tagctcagag aaccttcgaa     3540

aaaccgccct gcaaggcggt tttttcgttt tcagagcaag agattacgcg cagaccaaaa     3600

cgatctcaag aagatcatct tattaatcag ataaaatatt tctagatttc agtgcaattt     3660

atctcttcaa atgtagcacc tgaagtcagc cccatacgat ataagttgtt aattctcatg     3720

tttgacagct tatcatcgat                                                 3740


<210>  45
<211>  3117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  control cJun plasmid lacking the DNA-binding basic region

<400>  45
ctcgagaaat cataaaaaat ttatttgctt tgtgagcgga taacaattat aatagattca       60

attgtgagcg gataacaatt tcacacagaa ttcattaaag aggagaaatt aagcatgcac      120

catcaccatc accatgctag catcgcccgg ctggaggaaa aagtgaagac cttgaaggcc      180

cagaactatg agctggcgtc cacggccaac atgctccggg aacaggtggc acagcttggc      240

gcgccttaag gtagctctaa gcttaattag ctgagcttgg actcctgttg atagatccag      300

taatgacctc agaactccat ctggatttgt tcagaacgct cggttgccgc cgggcgtttt      360

ttattggtga gaatccaggc gagattttca ggagctaagg aagctaaaat ggagaaaaaa      420

atcactggat ataccaccgt tgatatatcc caatggcatc gtaaagaaca ttttgaggca      480

tttcagtcag ttgctcaatg tacctataac cagaccgttc agctggatat tacggccttt      540

ttaaagaccg taaagaaaaa taagcacaag ttttatccgg cctttattca cattcttgcc      600

cgcctgatga atgcttaatg aattacaaca gtactgcgat gagtggcagg gcggggcgta      660

atttttttaa ggcagttatt ggtgccctta aacgcctggg gtaatgactc tctagcttga      720

ggcatcaaat aaaacgaaag gctcagtcga aagactgggc ctttcgtttt atctgttgtt      780

tgtcggtgaa cgctctcctg agtaggacaa atccgccctc tagagctgcc tcgcgcgttt      840

cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca cagcttgtct      900

gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg ttggcgggtg      960

tcggggcgca gccatgaccc agtcacgtag cgatagcgga gtgtatactg gcttaactat     1020

gcggcatcag agcagattgt actgagagtg caccatatgc ggtgtgaaat accgcacaga     1080

tgcgtaagga gaaaataccg catcaggcgc tcttccgctt cctcgctcac tgactcgctg     1140

cgctcggtcg ttcggctgcg gcgagcggta tcagctcact caaaggcggt aatacggtta     1200

tccacagaat caggggataa cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc     1260

aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag     1320

catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac     1380

caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc     1440

ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt     1500

aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc     1560

gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga     1620

cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta     1680

ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag aaggacagta     1740

tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga     1800

tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg     1860

cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag     1920

tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc     1980

tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact     2040

tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt     2100

cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta     2160

ccatctggcc ccagtgctgc aatgataccg cgagacccac gctcaccggc tccagattta     2220

tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc     2280

gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat     2340

agtttgcgca acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt     2400

atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg     2460

tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca     2520

gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta     2580

agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg     2640

cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact     2700

ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg     2760

ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt     2820

actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga     2880

ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc     2940

atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa     3000

caaatagggg ttccgcgcac atttccccga aaagtgccac ctgacgtcta agaaaccatt     3060

attatcatga cattaaccta taaaaatagg cgtatcacga ggccctttcg tcttcac        3117


<210>  46
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  basic-c-Jun

<400>  46
cgcattaaag ccgaacgcaa acggatgcgc aaccgcatcg cagcctccaa gtgccgcaaa       60

cgcaaattgg agcgc                                                        75


<210>  47
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  basic-c-Jun

<400>  47

Arg Ile Lys Ala Glu Arg Lys Arg Met Arg Asn Arg Ile Ala Ala Ser 
1               5                   10                  15      


Lys Cys Arg Lys Arg Lys Leu Glu Arg 
            20                  25  


<210>  48
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ABeta1-42

<400>  48
gacgctgaat ttcgccacga ctccggctat gaggtacacc accagaaact ggtttttttt       60

gctgaggacg ttggctccaa caaaggtgct atcatcggtc tgatggttgg cggcgttgtt      120

atcgcttaa                                                              129


<210>  49
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABeta1-42

<400>  49

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210>  50
<211>  207
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  basic ABeta1-42

<400>  50
atgcgcatta aagccgaacg caaacggatg cgcaaccgca tcgcagcctc caagtgccgc       60

aaacgcaaat tggagcgcga cgctgaattt cgccacgact ccggctatga ggtacaccac      120

cagaaactgg ttttttttgc tgaggacgtt ggctccaaca aaggtgctat catcggtctg      180

atggttggcg gcgttgttat cgcttaa                                          207


<210>  51
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  basic Abeta1-42

<400>  51

Met Arg Ile Lys Ala Glu Arg Lys Arg Met Arg Asn Arg Ile Ala Ala 
1               5                   10                  15      


Ser Lys Cys Arg Lys Arg Lys Leu Glu Arg Asp Ala Glu Phe Arg His 
            20                  25                  30          


Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val Phe Phe Ala Glu 
        35                  40                  45              


Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly 
    50                  55                  60                  


Val Val Ile Ala 
65              


<210>  52
<211>  420
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AlphaS

<400>  52
gatgtattca tgaaaggact ttcaaaggcc aaggagggag ttgtggctgc tgctgagaaa       60

accaaacagg gtgtggcaga agcagcagga aagacaaaag agggtgttct ctatgtaggc      120

tccaaaacca aggagggagt ggtgcatggt gtggcaacag tggctgagaa gaccaaagag      180

caagtgacaa atgttggagg agcagtggtg acgggtgtga cagcagtagc ccagaagaca      240

gtggagggag cagggagcat tgcagcagcc actggctttg tcaaaaagga ccagttgggc      300

aagaatgaag aaggagcccc acaggaagga attctggaag atatgcctgt ggatcctgac      360

aatgaggctt atgaaatgcc ttctgaggaa gggtatcaag actacgaacc tgaagcctaa      420


<210>  53
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AlphaS

<400>  53

Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val Ala 
1               5                   10                  15      


Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys Thr 
            20                  25                  30          


Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val Val 
        35                  40                  45              


His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr Asn 
    50                  55                  60                  


Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys Thr 
65                  70                  75                  80  


Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys Lys 
                85                  90                  95      


Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile Leu 
            100                 105                 110         


Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro Ser 
        115                 120                 125             


Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
    130                 135                 


<210>  54
<211>  501
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  basic AlphaS

<400>  54
atgcgcatta aagccgaacg caaacggatg cgcaaccgca tcgcagcctc caagtgccgc       60

aaacgcaaat tggagcgcga tgtgtttatg aaaggtctga gcaaagcgaa agaaggcgtg      120

gtggctgcgg cggaaaaaac gaaacagggc gtggcggaag cggccggcaa aacgaaagaa      180

ggtgttctgt atgtcggcag caaaaccaaa gaaggcgtgg ttcatggtgt ggccaccgtt      240

gcagaaaaaa cgaaagaaca ggtcaccaac gtgggcggtg ctgtcgtgac cggtgttacg      300

gctgtcgcgc aaaaaacggt ggaaggcgcg ggttctattg cggcggcaac cggtttcgtt      360

aaaaaagatc agctgggtaa aaatgaagaa ggcgcgccgc aagaaggtat cctggaagac      420

atgccggtgg atccggacaa cgaagcgtat gaaatgccgt cggaagaagg ctatcaagac      480

tatgaaccgg aagcgtaatg a                                                501


<210>  55
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  basic AlphaS

<400>  55

Met Arg Ile Lys Ala Glu Arg Lys Arg Met Arg Asn Arg Ile Ala Ala 
1               5                   10                  15      


Ser Lys Cys Arg Lys Arg Lys Leu Glu Arg Asp Val Phe Met Lys Gly 
            20                  25                  30          


Leu Ser Lys Ala Lys Glu Gly Val Val Ala Ala Ala Glu Lys Thr Lys 
        35                  40                  45              


Gln Gly Val Ala Glu Ala Ala Gly Lys Thr Lys Glu Gly Val Leu Tyr 
    50                  55                  60                  


Val Gly Ser Lys Thr Lys Glu Gly Val Val His Gly Val Ala Thr Val 
65                  70                  75                  80  


Ala Glu Lys Thr Lys Glu Gln Val Thr Asn Val Gly Gly Ala Val Val 
                85                  90                  95      


Thr Gly Val Thr Ala Val Ala Gln Lys Thr Val Glu Gly Ala Gly Ser 
            100                 105                 110         


Ile Ala Ala Ala Thr Gly Phe Val Lys Lys Asp Gln Leu Gly Lys Asn 
        115                 120                 125             


Glu Glu Gly Ala Pro Gln Glu Gly Ile Leu Glu Asp Met Pro Val Asp 
    130                 135                 140                 


Pro Asp Asn Glu Ala Tyr Glu Met Pro Ser Glu Glu Gly Tyr Gln Asp 
145                 150                 155                 160 


Tyr Glu Pro Glu Ala 
                165 


<210>  56
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  binding site


<220>
<221>  misc_feature
<222>  (3)..(8)
<223>  n = A or T

<400>  56
ccnnnnnngg                                                              10


<210>  57
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  binding site

<400>  57
caggtg                                                                   6


<210>  58
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  binding site

<400>  58
cacctg                                                                   6


<210>  59
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  binding site


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n = A or T

<400>  59
tgnggg                                                                   6


<210>  60
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  binding site

<400>  60
tcacacct                                                                 8


<210>  61
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  binding site

<400>  61
tataaa                                                                   6


<210>  62
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  binding site

<400>  62
gttggcatgg caac                                                         14


<210>  63
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  binding site


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n = A or G

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  n = A or G

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n = C or T

<400>  63
nctaaccnnn                                                              10


<210>  64
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  binding site

<400>  64
aaatat                                                                   6


<210>  65
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  binding site


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n = A, C or G

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n = C, G or T

<400>  65
ncgcgn                                                                   6


<210>  66
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  binding site

<400>  66
taccgacat                                                                9


<210>  67
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  binding site

<400>  67
gataatgata atcattatc                                                    19


<210>  68
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  binding site

<400>  68
gccacgtggc                                                              10


<210>  69
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  binding site

<400>  69
agccgcc                                                                  7


<210>  70
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  binding site

<400>  70
acacca                                                                   6


<210>  71
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  binding site

<400>  71
tgtaaag                                                                  7


<210>  72
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  binding site

<400>  72
cctttt                                                                   6


<210>  73
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  binding site

<400>  73
atttactaac                                                              10


<210>  74
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  74

Gly Gly Gly Ser 
1               


<210>  75
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  75

Gly Gly Gly Gly Ser 
1               5   


<210>  76
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  76

Gly Gly Ser Gly 
1               


<210>  77
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  77

Gly Ser Gly Gly 
1               


<210>  78
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  78

Ser Gly Gly Gly 
1               


<210>  79
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  79

Ser Ser Gly Gly 
1               


<210>  80
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  80

Ser Ser Ser Gly 
1               


<210>  81
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  81

Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10      


<210>  82
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  82

Phe Leu Ile Val Ser Pro Thr Ala Tyr His Asn Asp Cys Arg Gly 
1               5                   10                  15  


<210>  83
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  83

Ile Met Thr Asn Lys Ser Arg 
1               5           


<210>  84
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  84

Tyr His Asn Asp 
1               


<210>  85
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  85

Phe Leu Ser Tyr Cys Trp 
1               5       


<210>  86
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  86

Leu Ile Val Ser Pro Thr Ala Gln Lys Glu Arg Gly 
1               5                   10          


<210>  87
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  87

Pro Leu Arg Asn 
1               


<210>  88
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  88

Pro Leu Lys Asp 
1               


<210>  89
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  89

Glu Leu Lys Glu 
1               


<210>  90
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  90

Glu Leu Arg Asn 
1               


<210>  91
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  91

Leu Ala Lys Ser 
1               


<210>  92
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  92

Ile Ala Gln Ser 
1               


<210>  93
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  93

Ala Leu Arg Leu 
1               


<210>  94
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  94

Ala Leu Arg Asn 
1               


<210>  95
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  95

Glu Val Gln Glu 
1               


<210>  96
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  96

Phe Leu Ile Val Ser Pro Thr Ala Tyr His Asn Asp Cys Arg Ser Gly 
1               5                   10                  15      


<210>  97
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Maf recognition elements (MAREs)

<400>  97
tgctgagcgt cagca                                                        15


