               SEQUENCE LISTING

<110> Medizinische Universität Wien

<120> Modified filamins and their uses

<130> AC2201 PCT S3

<150> EP20 15 5180.1
<151> 2020-02-03

<160> 56

<170> BiSSAP 1.3.6

<210> 1
<211> 2639
<212> PRT
<213> Homo sapiens


<220> 
<223> filamin-A isoform 1 modified

<400> 1
Met Ser Ser Ser His Ser Arg Ala Gly Gln Ser Ala Ala Gly Ala Ala 
1               5                   10                  15      
Pro Gly Gly Gly Val Asp Thr Arg Asp Ala Glu Met Pro Ala Thr Glu 
            20                  25                  30          
Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys Ile Gln Gln Asn Thr 
        35                  40                  45              
Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys Val Ser Lys Arg Ile 
    50                  55                  60                  
Ala Asn Leu Gln Thr Asp Leu Ser Asp Gly Leu Arg Leu Ile Ala Leu 
65                  70                  75                  80  
Leu Glu Val Leu Ser Gln Lys Lys Met His Arg Lys His Asn Gln Arg 
                85                  90                  95      
Pro Thr Phe Arg Gln Met Gln Leu Glu Asn Val Ser Val Ala Leu Glu 
            100                 105                 110         
Phe Leu Asp Arg Glu Ser Ile Lys Leu Val Ser Ile Asp Ser Lys Ala 
        115                 120                 125             
Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly Leu Ile Trp Thr Leu 
    130                 135                 140                 
Ile Leu His Tyr Ser Ile Ser Met Pro Met Trp Asp Glu Glu Glu Asp 
145                 150                 155                 160 
Glu Glu Ala Lys Lys Gln Thr Pro Lys Gln Arg Leu Leu Gly Trp Ile 
                165                 170                 175     
Gln Asn Lys Leu Pro Gln Leu Pro Ile Thr Asn Phe Ser Arg Asp Trp 
            180                 185                 190         
Gln Ser Gly Arg Ala Leu Gly Ala Leu Val Asp Ser Cys Ala Pro Gly 
        195                 200                 205             
Leu Cys Pro Asp Trp Asp Ser Trp Asp Ala Ser Lys Pro Val Thr Asn 
    210                 215                 220                 
Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp Leu Gly Ile Pro Gln 
225                 230                 235                 240 
Val Ile Thr Pro Glu Glu Ile Val Asp Pro Asn Val Asp Glu His Ser 
                245                 250                 255     
Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala Lys Leu Lys Pro Gly 
            260                 265                 270         
Ala Pro Leu Arg Pro Lys Leu Asn Pro Lys Lys Ala Arg Ala Tyr Gly 
        275                 280                 285             
Pro Gly Ile Glu Pro Thr Gly Asn Met Val Lys Lys Arg Ala Glu Phe 
    290                 295                 300                 
Thr Val Glu Thr Arg Ser Ala Gly Gln Gly Glu Val Leu Val Tyr Val 
305                 310                 315                 320 
Glu Asp Pro Ala Gly His Gln Glu Glu Ala Lys Val Thr Ala Asn Asn 
                325                 330                 335     
Asp Lys Asn Arg Thr Phe Ser Val Trp Tyr Val Pro Glu Val Thr Gly 
            340                 345                 350         
Thr His Lys Val Thr Val Leu Phe Ala Gly Gln His Ile Ala Lys Ser 
        355                 360                 365             
Pro Phe Glu Val Tyr Val Asp Lys Ser Gln Gly Asp Ala Ser Lys Val 
    370                 375                 380                 
Thr Ala Gln Gly Pro Gly Leu Glu Pro Ser Gly Asn Ile Ala Asn Lys 
385                 390                 395                 400 
Thr Thr Tyr Phe Glu Ile Phe Thr Ala Gly Ala Gly Thr Gly Glu Val 
                405                 410                 415     
Glu Val Val Ile Gln Asp Pro Met Gly Gln Lys Gly Thr Val Glu Pro 
            420                 425                 430         
Gln Leu Glu Ala Arg Gly Asp Ser Thr Tyr Arg Cys Ser Tyr Gln Pro 
        435                 440                 445             
Thr Met Glu Gly Val His Thr Val His Val Thr Phe Ala Gly Val Pro 
    450                 455                 460                 
Ile Pro Arg Ser Pro Tyr Thr Val Thr Val Gly Gln Ala Cys Asn Pro 
465                 470                 475                 480 
Ser Ala Cys Arg Ala Val Gly Arg Gly Leu Gln Pro Lys Gly Val Arg 
                485                 490                 495     
Val Lys Glu Thr Ala Asp Phe Lys Val Tyr Thr Lys Gly Ala Gly Ser 
            500                 505                 510         
Gly Glu Leu Lys Val Thr Val Lys Gly Pro Lys Gly Glu Glu Arg Val 
        515                 520                 525             
Lys Gln Lys Asp Leu Gly Asp Gly Val Tyr Gly Phe Glu Tyr Tyr Pro 
    530                 535                 540                 
Met Val Pro Gly Thr Tyr Ile Val Thr Ile Thr Trp Gly Gly Gln Asn 
545                 550                 555                 560 
Ile Gly Arg Ser Pro Phe Glu Val Lys Val Gly Thr Glu Cys Gly Asn 
                565                 570                 575     
Gln Lys Val Arg Ala Trp Gly Pro Gly Leu Glu Gly Gly Val Val Gly 
            580                 585                 590         
Lys Ser Ala Asp Phe Val Val Glu Ala Ile Gly Asp Asp Val Gly Thr 
        595                 600                 605             
Leu Gly Phe Ser Val Glu Gly Pro Ser Gln Ala Lys Ile Glu Cys Asp 
    610                 615                 620                 
Asp Lys Gly Asp Gly Ser Cys Asp Val Arg Tyr Trp Pro Gln Glu Ala 
625                 630                 635                 640 
Gly Glu Tyr Ala Val His Val Leu Cys Asn Ser Glu Asp Ile Arg Leu 
                645                 650                 655     
Ser Pro Phe Met Ala Asp Ile Arg Asp Ala Pro Gln Asp Phe His Pro 
            660                 665                 670         
Asp Arg Val Lys Ala Arg Gly Pro Gly Leu Glu Lys Thr Gly Val Ala 
        675                 680                 685             
Val Asn Lys Pro Ala Glu Phe Thr Val Asp Ala Lys His Gly Gly Lys 
    690                 695                 700                 
Ala Pro Leu Arg Val Gln Val Gln Asp Asn Glu Gly Cys Pro Val Glu 
705                 710                 715                 720 
Ala Leu Val Lys Asp Asn Gly Asn Gly Thr Tyr Ser Cys Ser Tyr Val 
                725                 730                 735     
Pro Arg Lys Pro Val Lys His Thr Ala Met Val Ser Trp Gly Gly Val 
            740                 745                 750         
Ser Ile Pro Asn Ser Pro Phe Arg Val Asn Val Gly Ala Gly Ser His 
        755                 760                 765             
Pro Asn Lys Val Lys Val Tyr Gly Pro Gly Val Ala Lys Thr Gly Leu 
    770                 775                 780                 
Lys Ala His Glu Pro Thr Tyr Phe Thr Val Asp Cys Ala Glu Ala Gly 
785                 790                 795                 800 
Gln Gly Asp Val Ser Ile Gly Ile Lys Cys Ala Pro Gly Val Val Gly 
                805                 810                 815     
Pro Ala Glu Ala Asp Ile Asp Phe Asp Ile Ile Arg Asn Asp Asn Asp 
            820                 825                 830         
Thr Phe Thr Val Lys Tyr Thr Pro Arg Gly Ala Gly Ser Tyr Thr Ile 
        835                 840                 845             
Met Val Leu Phe Ala Asp Gln Ala Thr Pro Thr Ser Pro Ile Arg Val 
    850                 855                 860                 
Lys Val Glu Pro Ser His Asp Ala Ser Lys Val Lys Ala Glu Gly Pro 
865                 870                 875                 880 
Gly Leu Ser Arg Thr Gly Val Glu Leu Gly Lys Pro Thr His Phe Thr 
                885                 890                 895     
Val Asn Ala Lys Ala Ala Gly Lys Gly Lys Leu Asp Val Gln Phe Ser 
            900                 905                 910         
Gly Leu Thr Lys Gly Asp Ala Val Arg Asp Val Asp Ile Ile Asp His 
        915                 920                 925             
His Asp Asn Thr Tyr Thr Val Lys Tyr Thr Pro Val Gln Gln Gly Pro 
    930                 935                 940                 
Val Gly Val Asn Val Thr Tyr Gly Gly Asp Pro Ile Pro Lys Ser Pro 
945                 950                 955                 960 
Phe Ser Val Ala Val Ser Pro Ser Leu Asp Leu Ser Lys Ile Lys Val 
                965                 970                 975     
Ser Gly Leu Gly Glu Lys Val Asp Val Gly Lys Asp Gln Glu Phe Thr 
            980                 985                 990         
Val Lys Ser Lys Gly Ala Gly Gly Gln Gly Lys Val Ala Ser Lys Ile 
        995                 1000                1005            
Val Gly Pro Ser Gly Ala Ala Val Pro Cys Lys Val Glu Pro Gly Leu 
    1010                1015                1020                
Gly Ala Asp Asn Ser Val Val Arg Phe Leu Pro Arg Glu Glu Gly Pro 
1025                1030                1035                1040
Tyr Glu Val Glu Val Thr Tyr Asp Gly Val Pro Val Pro Gly Ser Pro 
                1045                1050                1055    
Phe Pro Leu Glu Ala Val Ala Pro Thr Lys Pro Ser Lys Val Lys Ala 
            1060                1065                1070        
Phe Gly Pro Gly Leu Gln Gly Gly Ser Ala Gly Ser Pro Ala Arg Phe 
        1075                1080                1085            
Thr Ile Asp Thr Lys Gly Ala Gly Thr Gly Gly Leu Gly Leu Thr Val 
    1090                1095                1100                
Glu Gly Pro Cys Glu Ala Gln Leu Glu Cys Leu Asp Asn Gly Asp Gly 
1105                1110                1115                1120
Thr Cys Ser Val Ser Tyr Val Pro Thr Glu Pro Gly Asp Tyr Asn Ile 
                1125                1130                1135    
Asn Ile Leu Phe Ala Asp Thr His Ile Pro Gly Ser Pro Phe Lys Ala 
            1140                1145                1150        
His Val Val Pro Cys Phe Asp Ala Ser Lys Val Lys Cys Ser Gly Pro 
        1155                1160                1165            
Gly Leu Glu Arg Ala Thr Ala Gly Glu Val Gly Gln Phe Gln Val Asp 
    1170                1175                1180                
Cys Ser Ser Ala Gly Ser Ala Glu Leu Thr Ile Glu Ile Cys Ser Glu 
1185                1190                1195                1200
Ala Gly Leu Pro Ala Glu Val Tyr Ile Gln Asp His Gly Asp Gly Thr 
                1205                1210                1215    
His Thr Ile Thr Tyr Ile Pro Leu Cys Pro Gly Ala Tyr Thr Val Thr 
            1220                1225                1230        
Ile Lys Tyr Gly Gly Gln Pro Val Pro Asn Phe Pro Ser Lys Leu Gln 
        1235                1240                1245            
Val Glu Pro Ala Val Asp Thr Ser Gly Val Gln Cys Tyr Gly Pro Gly 
    1250                1255                1260                
Ile Glu Gly Gln Gly Val Phe Arg Glu Ala Thr Thr Glu Phe Ser Val 
1265                1270                1275                1280
Asp Ala Arg Ala Leu Thr Gln Thr Gly Gly Pro His Val Lys Ala Arg 
                1285                1290                1295    
Val Ala Asn Pro Ser Gly Asn Leu Thr Glu Thr Tyr Val Gln Asp Arg 
            1300                1305                1310        
Gly Asp Gly Met Tyr Lys Val Glu Tyr Thr Pro Tyr Glu Glu Gly Leu 
        1315                1320                1325            
His Ser Val Asp Val Thr Tyr Asp Gly Ser Pro Val Pro Ser Ser Pro 
    1330                1335                1340                
Phe Gln Val Pro Val Thr Glu Gly Cys Asp Pro Ser Arg Val Arg Val 
1345                1350                1355                1360
His Gly Pro Gly Ile Gln Ser Gly Thr Thr Asn Lys Pro Asn Lys Phe 
                1365                1370                1375    
Thr Val Glu Thr Arg Gly Ala Gly Thr Gly Gly Leu Gly Leu Ala Val 
            1380                1385                1390        
Glu Gly Pro Ser Glu Ala Lys Met Ser Cys Met Asp Asn Lys Asp Gly 
        1395                1400                1405            
Ser Cys Ser Val Glu Tyr Ile Pro Tyr Glu Ala Gly Thr Tyr Ser Leu 
    1410                1415                1420                
Asn Val Thr Tyr Gly Gly His Gln Val Pro Gly Ser Pro Phe Lys Val 
1425                1430                1435                1440
Pro Val His Asp Val Thr Asp Ala Ser Lys Val Lys Cys Ser Gly Pro 
                1445                1450                1455    
Gly Leu Ser Pro Gly Met Val Arg Ala Asn Leu Pro Gln Ser Phe Gln 
            1460                1465                1470        
Val Asp Thr Ser Lys Ala Gly Val Ala Pro Leu Gln Val Lys Val Gln 
        1475                1480                1485            
Gly Pro Lys Gly Leu Val Glu Pro Val Asp Val Val Asp Asn Ala Asp 
    1490                1495                1500                
Gly Thr Gln Thr Val Asn Tyr Val Pro Ser Arg Glu Gly Pro Tyr Ser 
1505                1510                1515                1520
Ile Ser Val Leu Tyr Gly Asp Glu Glu Val Pro Arg Ser Pro Phe Lys 
                1525                1530                1535    
Val Lys Val Leu Pro Thr His Asp Ala Ser Lys Val Lys Ala Ser Gly 
            1540                1545                1550        
Pro Gly Leu Asn Thr Thr Gly Val Pro Ala Ser Leu Pro Val Glu Phe 
        1555                1560                1565            
Thr Ile Asp Ala Lys Asp Ala Gly Glu Gly Leu Leu Ala Val Gln Ile 
    1570                1575                1580                
Thr Asp Pro Glu Gly Lys Pro Lys Lys Thr His Ile Gln Asp Asn His 
1585                1590                1595                1600
Asp Gly Thr Tyr Thr Val Ala Tyr Val Pro Asp Val Thr Gly Arg Tyr 
                1605                1610                1615    
Thr Ile Leu Ile Lys Tyr Gly Gly Asp Glu Ile Pro Phe Ser Pro Tyr 
            1620                1625                1630        
Arg Val Arg Ala Val Pro Thr Gly Asp Ala Ser Lys Cys Thr Val Thr 
        1635                1640                1645            
Gly Ala Gly Ile Gly Pro Thr Ile Gln Ile Gly Glu Glu Thr Val Ile 
    1650                1655                1660                
Thr Val Asp Thr Lys Ala Ala Gly Lys Gly Lys Val Thr Cys Thr Val 
1665                1670                1675                1680
Cys Thr Pro Asp Gly Ser Glu Val Asp Val Asp Val Val Glu Asn Glu 
                1685                1690                1695    
Asp Gly Thr Phe Asp Ile Phe Tyr Thr Ala Pro Gln Pro Gly Lys Tyr 
            1700                1705                1710        
Val Ile Cys Val Arg Phe Gly Gly Glu His Val Pro Asn Ser Pro Phe 
        1715                1720                1725            
Gln Val Thr Ala Leu Ala Gly Asp Gln Pro Ser Val Gln Pro Pro Leu 
    1730                1735                1740                
Arg Ser Gln Gln Leu Ala Pro Gln Tyr Thr Tyr Ala Gln Gly Gly Gln 
1745                1750                1755                1760
Gln Thr Trp Ala Pro Glu Arg Pro Leu Val Gly Val Asn Gly Leu Asp 
                1765                1770                1775    
Val Thr Ser Leu Arg Pro Phe Asp Leu Val Ile Pro Phe Thr Ile Lys 
            1780                1785                1790        
Lys Gly Glu Ile Thr Gly Glu Val Arg Met Pro Ser Gly Lys Val Ala 
        1795                1800                1805            
Gln Pro Thr Ile Thr Asp Asn Lys Asp Gly Thr Val Thr Val Arg Tyr 
    1810                1815                1820                
Ala Pro Ser Glu Ala Gly Leu His Glu Met Asp Ile Arg Tyr Asp Asn 
1825                1830                1835                1840
Met His Ile Pro Gly Ser Pro Leu Gln Phe Tyr Val Asp Tyr Val Asn 
                1845                1850                1855    
Cys Gly His Val Thr Ala Tyr Gly Pro Gly Leu Thr His Gly Val Val 
            1860                1865                1870        
Asn Lys Pro Ala Thr Phe Thr Val Asn Thr Lys Asp Ala Gly Glu Gly 
        1875                1880                1885            
Gly Leu Ser Leu Ala Ile Glu Gly Pro Ser Lys Ala Glu Ile Ser Cys 
    1890                1895                1900                
Thr Asp Asn Gln Asp Gly Thr Cys Ser Val Ser Tyr Leu Pro Val Leu 
1905                1910                1915                1920
Pro Gly Asp Tyr Ser Ile Leu Val Lys Tyr Asn Glu Gln His Val Pro 
                1925                1930                1935    
Gly Ser Pro Phe Thr Ala Arg Val Thr Gly Asp Asp Ser Met Arg Met 
            1940                1945                1950        
Ser His Leu Lys Val Gly Ser Ala Ala Asp Ile Pro Ile Asn Ile Ser 
        1955                1960                1965            
Glu Thr Asp Leu Ser Leu Leu Thr Ala Thr Val Val Pro Pro Ser Gly 
    1970                1975                1980                
Arg Glu Glu Pro Cys Leu Leu Lys Arg Leu Arg Asn Gly His Val Gly 
1985                1990                1995                2000
Ile Ser Phe Val Pro Lys Glu Thr Gly Glu His Leu Val His Val Lys 
                2005                2010                2015    
Lys Asn Gly Gln His Val Ala Ser Ser Pro Ile Pro Val Val Ile Ser 
            2020                2025                2030        
Gln Ser Glu Ile Gly Asp Ala Ser Arg Val Arg Val Ser Gly Gln Gly 
        2035                2040                2045            
Leu His Glu Gly His Thr Phe Glu Pro Ala Glu Phe Ile Ile Asp Thr 
    2050                2055                2060                
Arg Asp Ala Gly Tyr Gly Gly Leu Ser Leu Ser Ile Glu Gly Pro Ser 
2065                2070                2075                2080
Lys Val Asp Ile Asn Thr Glu Asp Leu Glu Asp Gly Thr Cys Arg Val 
                2085                2090                2095    
Thr Tyr Cys Pro Thr Glu Pro Gly Asn Tyr Ile Ile Asn Ile Lys Phe 
            2100                2105                2110        
Ala Asp Gln His Val Pro Gly Ser Pro Phe Ser Val Lys Val Thr Gly 
        2115                2120                2125            
Glu Gly Arg Val Lys Glu Ser Ile Thr Arg Arg Arg Arg Ala Pro Ser 
    2130                2135                2140                
Val Ala Asn Val Gly Ser His Cys Asp Leu Ser Leu Lys Ile Pro Glu 
2145                2150                2155                2160
Ile Ser Ile Gln Asp Met Thr Ala Gln Val Thr Ser Pro Ser Gly Lys 
                2165                2170                2175    
Thr His Glu Ala Glu Ile Val Glu Gly Glu Asn His Thr Tyr Cys Ile 
            2180                2185                2190        
Arg Phe Val Pro Ala Glu Met Gly Thr His Thr Val Ser Val Lys Tyr 
        2195                2200                2205            
Lys Gly Gln His Val Pro Gly Ser Pro Phe Gln Phe Thr Val Gly Pro 
    2210                2215                2220                
Leu Gly Glu Gly Gly Ala His Lys Val Arg Ala Gly Gly Pro Gly Leu 
2225                2230                2235                2240
Glu Arg Ala Glu Ala Gly Val Pro Ala Glu Phe Ser Ile Trp Thr Arg 
                2245                2250                2255    
Glu Ala Gly Ala Gly Gly Leu Ala Ile Ala Val Glu Gly Pro Ser Lys 
            2260                2265                2270        
Ala Glu Ile Ser Phe Glu Asp Arg Lys Asp Gly Ser Cys Gly Val Ala 
        2275                2280                2285            
Tyr Val Val Gln Glu Pro Gly Asp Tyr Glu Val Ser Val Lys Phe Asn 
    2290                2295                2300                
Glu Glu His Ile Pro Asp Ser Pro Phe Val Val Pro Val Ala Ser Pro 
2305                2310                2315                2320
Ser Gly Asp Ala Arg Arg Leu Thr Val Ser Ser Leu Arg Glu Ser Gly 
                2325                2330                2335    
Leu Lys Val Asn Gln Pro Ala Ser Phe Ala Val Ser Leu Asn Gly Ala 
            2340                2345                2350        
Lys Gly Ala Ile Asp Ala Lys Val His Ser Pro Ser Gly Ala Leu Glu 
        2355                2360                2365            
Glu Cys Tyr Val Thr Glu Ile Asp Gln Asp Lys Tyr Ala Val Arg Phe 
    2370                2375                2380                
Ile Pro Arg Glu Asn Gly Val Tyr Leu Ile Asp Val Lys Phe Asn Gly 
2385                2390                2395                2400
Thr His Ile Pro Gly Ser Pro Phe Lys Ile Arg Val Gly Glu Pro Gly 
                2405                2410                2415    
His Gly Gly Asp Pro Gly Leu Val Ser Ala Tyr Gly Ala Gly Leu Glu 
            2420                2425                2430        
Gly Gly Val Thr Gly Asn Pro Ala Glu Phe Val Val Asn Thr Ser Asn 
        2435                2440                2445            
Ala Gly Ala Gly Ala Leu Ser Val Thr Ile Asp Gly Pro Ser Lys Val 
    2450                2455                2460                
Lys Met Asp Cys Gln Glu Cys Pro Glu Gly Tyr Arg Val Thr Tyr Thr 
2465                2470                2475                2480
Pro Met Ala Pro Gly Ser Tyr Leu Ile Ser Ile Lys Tyr Gly Gly Pro 
                2485                2490                2495    
Tyr His Ile Gly Gly Ser Pro Phe Lys Ala Lys Val Thr Gly Pro Arg 
            2500                2505                2510        
Leu Val Ser Asn His Ser Leu His Glu Thr Ser Ser Val Phe Val Asp 
        2515                2520                2525            
Ser Leu Thr Lys Ala Thr Cys Ala Pro Gln His Gly Ala Pro Gly Pro 
    2530                2535                2540                
Gly Pro Ala Asp Ala Ser Lys Val Val Ala Lys Gly Leu Gly Leu Ser 
2545                2550                2555                2560
Lys Ala Tyr Val Gly Gln Lys Ser Ser Phe Thr Val Asp Cys Ser Lys 
                2565                2570                2575    
Ala Gly Asn Asn Met Leu Leu Val Gly Val His Gly Pro Arg Thr Pro 
            2580                2585                2590        
Cys Glu Glu Ile Leu Val Lys His Val Gly Ser Arg Leu Tyr Ser Val 
        2595                2600                2605            
Ser Tyr Leu Leu Lys Asp Lys Gly Glu Tyr Thr Leu Val Val Lys Trp 
    2610                2615                2620                
Gly Asp Glu His Ile Pro Gly Ser Pro Tyr Arg Val Val Val Pro 
2625                2630                2635                

<210> 2
<211> 7920
<212> DNA
<213> Homo sapiens


<220> 
<223> filamin A isoform 1 modified cDNA

<400> 2
atgagtagct cccactctcg ggcgggccag agcgcagcag gcgcggctcc gggcggcggc       60

gtcgacacgc gggacgccga gatgccggcc accgagaagg acctggcgga ggacgcgccg      120

tggaagaaga tccagcagaa cactttcacg cgctggtgca acgagcacct gaagtgcgtg      180

agcaagcgca tcgccaacct gcagacggac ctgagcgacg ggctgcggct tatcgcgctg      240

ttggaggtgc tcagccagaa gaagatgcac cgcaagcaca accagcggcc cactttccgc      300

caaatgcagc ttgagaacgt gtcggtggcg ctcgagttcc tggaccgcga gagcatcaaa      360

ctggtgtcca tcgacagcaa ggccatcgtg gacgggaacc tgaagctgat cctgggcctc      420

atctggaccc tgatcctgca ctactccatc tccatgccca tgtgggacga ggaggaggat      480

gaggaggcca agaagcagac ccccaagcag aggctcctgg gctggatcca gaacaagctg      540

ccgcagctgc ccatcaccaa cttcagccgg gactggcaga gcggccgggc cctgggcgcc      600

ctggtggaca gctgtgcccc gggcctgtgt cctgactggg actcttggga cgccagcaag      660

cccgttacca atgcgcgaga ggccatgcag caggcggatg actggctggg catcccccag      720

gtgatcaccc ccgaggagat tgtggacccc aacgtggacg agcactctgt catgacctac      780

ctgtcccagt tccccaaggc caagctgaag ccaggggctc ccttgcggcc caaactgaac      840

ccgaagaaag cccgtgccta cgggccaggc atcgagccca caggcaacat ggtgaagaag      900

cgggcagagt tcactgtgga gaccagaagt gctggccagg gagaggtgct ggtgtacgtg      960

gaggacccgg ccggacacca ggaggaggca aaagtgaccg ccaataacga caagaaccgc     1020

accttctccg tctggtacgt ccccgaggtg acggggactc ataaggttac tgtgctcttt     1080

gctggccagc acatcgccaa gagccccttc gaggtgtacg tggataagtc acagggtgac     1140

gccagcaaag tgacagccca aggtcccggc ctggagccca gtggcaacat cgccaacaag     1200

accacctact ttgagatctt tacggcagga gctggcacgg gcgaggtcga ggttgtgatc     1260

caggacccca tgggacagaa gggcacggta gagcctcagc tggaggcccg gggcgacagc     1320

acataccgct gcagctacca gcccaccatg gagggcgtcc acaccgtgca cgtcacgttt     1380

gccggcgtgc ccatccctcg cagcccctac actgtcactg ttggccaagc ctgtaacccg     1440

agtgcctgcc gggcggttgg ccggggcctc cagcccaagg gtgtgcgggt gaaggagaca     1500

gctgacttca aggtgtacac aaagggcgct ggcagtgggg agctgaaggt caccgtgaag     1560

ggccccaagg gagaggagcg cgtgaagcag aaggacctgg gggatggcgt gtatggcttc     1620

gagtattacc ccatggtccc tggaacctat atcgtcacca tcacgtgggg tggtcagaac     1680

atcgggcgca gtcccttcga agtgaaggtg ggcaccgagt gtggcaatca gaaggtacgg     1740

gcctggggcc ctgggctgga gggcggcgtc gttggcaagt cagcagactt tgtggtggag     1800

gctatcgggg acgacgtggg cacgctgggc ttctcggtgg aagggccatc gcaggctaag     1860

atcgaatgtg acgacaaggg cgacggctcc tgtgatgtgc gctactggcc gcaggaggct     1920

ggcgagtatg ccgttcacgt gctgtgcaac agcgaagaca tccgcctcag ccccttcatg     1980

gctgacatcc gtgacgcgcc ccaggacttc cacccagaca gggtgaaggc acgtgggcct     2040

ggattggaga agacaggtgt ggccgtcaac aagccagcag agttcacagt ggatgccaag     2100

cacggtggca aggccccact tcgggtccaa gtccaggaca atgaaggctg ccctgtggag     2160

gcgttggtca aggacaacgg caatggcact tacagctgct cctacgtgcc caggaagccg     2220

gtgaagcaca cagccatggt gtcctgggga ggcgtcagca tccccaacag ccccttcagg     2280

gtgaatgtgg gagctggcag ccaccccaac aaggtcaaag tatacggccc cggagtagcc     2340

aagacagggc tcaaggccca cgagcccacc tacttcactg tggactgcgc cgaggctggc     2400

cagggggacg tcagcatcgg catcaagtgt gcccctggag tggtaggccc cgccgaagct     2460

gacatcgact tcgacatcat ccgcaatgac aatgacacct tcacggtcaa gtacacgccc     2520

cggggggctg gcagctacac cattatggtc ctctttgctg accaggccac gcccaccagc     2580

cccatccgag tcaaggtgga gccctctcat gacgccagta aggtgaaggc cgagggccct     2640

ggcctcagtc gcactggtgt cgagcttggc aagcccaccc acttcacagt aaatgccaaa     2700

gctgctggca aaggcaagct ggacgtccag ttctcaggac tcaccaaggg ggatgcagtg     2760

cgagatgtgg acatcatcga ccaccatgac aacacctaca cagtcaagta cacgcctgtc     2820

cagcagggtc cagtaggcgt caatgtcact tatggagggg atcccatccc taagagccct     2880

ttctcagtgg cagtatctcc aagcctggac ctcagcaaga tcaaggtgtc tggcctggga     2940

gagaaggtgg acgttggcaa agaccaggag ttcacagtca aatcaaaggg tgctggtggt     3000

caaggcaaag tggcatccaa gattgtgggc ccctcgggtg cagcggtgcc ctgcaaggtg     3060

gagccaggcc tgggggctga caacagtgtg gtgcgcttcc tgccccgtga ggaagggccc     3120

tatgaggtgg aggtgaccta tgacggcgtg cccgtgcctg gcagcccctt tcctctggaa     3180

gctgtggccc ccaccaagcc tagcaaggtg aaggcgtttg ggccggggct gcagggaggc     3240

agtgcgggct cccccgcccg cttcaccatc gacaccaagg gcgccggcac aggtggcctg     3300

ggcctgacgg tggagggccc ctgtgaggcg cagctcgagt gcttggacaa tggggatggc     3360

acatgttccg tgtcctacgt gcccaccgag cccggggact acaacatcaa catcctcttc     3420

gctgacaccc acatccctgg ctccccattc aaggcccacg tggttccctg ctttgacgca     3480

tccaaagtca agtgctcagg ccccgggctg gagcgggcca ccgctgggga ggtgggccaa     3540

ttccaagtgg actgctcgag cgcgggcagc gcggagctga ccattgagat ctgctcggag     3600

gcggggcttc cggccgaggt gtacatccag gaccacggtg atggcacgca caccattacc     3660

tacattcccc tctgccccgg ggcctacacc gtcaccatca agtacggcgg ccagcccgtg     3720

cccaacttcc ccagcaagct gcaggtggaa cctgcggtgg acacttccgg tgtccagtgc     3780

tatgggcctg gtattgaggg ccagggtgtc ttccgtgagg ccaccactga gttcagtgtg     3840

gacgcccggg ctctgacaca gaccggaggg ccgcacgtca aggcccgtgt ggccaacccc     3900

tcaggcaacc tgacggagac ctacgttcag gaccgtggcg atggcatgta caaagtggag     3960

tacacgcctt acgaggaggg actgcactcc gtggacgtga cctatgacgg cagtcccgtg     4020

cccagcagcc ccttccaggt gcccgtgacc gagggctgcg acccctcccg ggtgcgtgtc     4080

cacgggccag gcatccaaag tggcaccacc aacaagccca acaagttcac tgtggagacc     4140

aggggagctg gcacgggcgg cctgggcctg gctgtagagg gcccctccga ggccaagatg     4200

tcctgcatgg ataacaagga cggcagctgc tcggtcgagt acatccctta tgaggctggc     4260

acctacagcc tcaacgtcac ctatggtggc catcaagtgc caggcagtcc tttcaaggtc     4320

cctgtgcatg atgtgacaga tgcgtccaag gtcaagtgct ctgggcccgg cctgagccca     4380

ggcatggttc gtgccaacct ccctcagtcc ttccaggtgg acacaagcaa ggctggtgtg     4440

gccccattgc aggtcaaagt gcaagggccc aaaggcctgg tggagccagt ggacgtggta     4500

gacaacgctg atggcaccca gaccgtcaat tatgtgccca gccgagaagg gccctacagc     4560

atctcagtac tgtatggaga tgaagaggta ccccggagcc ccttcaaggt caaggtgctg     4620

cctactcatg atgccagcaa ggtgaaggcc agtggccccg ggctcaacac cactggcgtg     4680

cctgccagcc tgcccgtgga gttcaccatc gatgcaaagg acgccgggga gggcctgctg     4740

gctgtccaga tcacggatcc cgaaggcaag ccgaagaaga cacacatcca agacaaccat     4800

gacggcacgt atacagtggc ctacgtgcca gacgtgacag gtcgctacac catcctcatc     4860

aagtacggtg gtgacgagat ccccttctcc ccgtaccgcg tgcgtgccgt gcccaccggg     4920

gacgccagca agtgcactgt cacaggtgct ggcatcggcc ccaccattca gattggggag     4980

gagacggtga tcactgtgga cactaaggcg gcaggcaaag gcaaagtgac gtgcaccgtg     5040

tgcacgcctg atggctcaga ggtggatgtg gacgtggtgg agaatgagga cggcactttc     5100

gacatcttct acacggcccc ccagccgggc aaatacgtca tctgtgtgcg ctttggtggc     5160

gagcacgtgc ccaacagccc cttccaagtg acggctctgg ctggggacca gccctcggtg     5220

cagccccctc tacggtctca gcagctggcc ccacagtaca cctacgccca gggcggccag     5280

cagacttggg ccccggagag gcccctggtg ggtgtcaatg ggctggatgt gaccagcctg     5340

aggccctttg accttgtcat ccccttcacc atcaagaagg gcgagatcac aggggaggtt     5400

cggatgccct caggcaaggt ggcgcagccc accatcactg acaacaaaga cggcaccgtg     5460

accgtgcggt atgcacccag cgaggctggc ctgcacgaga tggacatccg ctatgacaac     5520

atgcacatcc caggaagccc cttgcagttc tatgtggatt acgtcaactg tggccatgtc     5580

actgcctatg ggcctggcct cacccatgga gtagtgaaca agcctgccac cttcaccgtc     5640

aacaccaagg atgcaggaga ggggggcctg tctctggcca ttgagggccc gtccaaagca     5700

gaaatcagct gcactgacaa ccaggatggg acatgcagcg tgtcctacct gcctgtgctg     5760

ccgggggact acagcattct agtcaagtac aatgaacagc acgtcccagg cagccccttc     5820

actgctcggg tcacaggtga cgactccatg cgtatgtccc acctaaaggt cggctctgct     5880

gccgacatcc ccatcaacat ctcagagacg gatctcagcc tgctgacggc cactgtggtc     5940

ccgccctcgg gccgggagga gccctgtttg ctgaagcggc tgcgtaatgg ccacgtgggg     6000

atttcattcg tgcccaagga gacgggggag cacctggtgc atgtgaagaa aaatggccag     6060

cacgtggcca gcagccccat cccggtggtg atcagccagt cggaaattgg ggatgccagt     6120

cgtgttcggg tctctggtca gggccttcac gaaggccaca cctttgagcc tgcagagttt     6180

atcattgata cccgcgatgc aggctatggt gggctcagcc tgtccattga gggccccagc     6240

aaggtggaca tcaacacaga ggacctggag gacgggacgt gcagggtcac ctactgcccc     6300

acagagccag gcaactacat catcaacatc aagtttgccg accagcacgt gcctggcagc     6360

cccttctctg tgaaggtgac aggcgagggc cgggtgaaag agagcatcac ccgcaggcgt     6420

cgggctcctt cagtggccaa cgttggtagt cattgtgacc tcagcctgaa aatccctgaa     6480

attagcatcc aggatatgac agcccaggtg accagcccat cgggcaagac ccatgaggcc     6540

gagatcgtgg aaggggagaa ccacacctac tgcatccgct ttgttcccgc tgagatgggc     6600

acacacacag tcagcgtgaa gtacaagggc cagcacgtgc ctgggagccc cttccagttc     6660

accgtggggc ccctagggga agggggagcc cacaaggtcc gagctggggg ccctggcctg     6720

gagagagctg aagctggagt gccagccgaa ttcagtatct ggacccggga agctggtgct     6780

ggaggcctgg ccattgctgt cgagggcccc agcaaggctg agatctcttt tgaggaccgc     6840

aaggacggct cctgtggtgt ggcttatgtg gtccaggagc caggtgacta cgaagtctca     6900

gtcaagttca acgaggaaca cattcccgac agccccttcg tggtgcctgt ggcttctccg     6960

tctggcgacg cccgccgcct cactgtttct agccttcggg agtcagggct aaaggtcaac     7020

cagccagcct cttttgcagt cagcctgaac ggggccaagg gggcgatcga tgccaaggtg     7080

cacagcccct caggagccct ggaggagtgc tatgtcacag aaattgacca agataagtat     7140

gctgtgcgct tcatccctcg ggagaatggc gtttacctga ttgacgtcaa gttcaacggc     7200

acccacatcc ctggaagccc cttcaagatc cgagttgggg agcctgggca tggaggggac     7260

ccaggcttgg tgtctgctta cggagcaggt ctggaaggcg gtgtcacagg gaacccagct     7320

gagttcgtcg tgaacacgag caatgcggga gctggtgccc tgtcggtgac cattgacggc     7380

ccctccaagg tgaagatgga ttgccaggag tgccctgagg gctaccgcgt cacctatacc     7440

cccatggcac ctggcagcta cctcatctcc atcaagtacg gcggccccta ccacattggg     7500

ggcagcccct tcaaggccaa agtcacaggc ccccgtctcg tcagcaacca cagcctccac     7560

gagacatcat cagtgtttgt agactctctg accaaggcca cctgtgcccc ccagcatggg     7620

gccccgggtc ctgggcctgc tgacgccagc aaggtggtgg ccaagggcct ggggctgagc     7680

aaggcctacg taggccagaa gagcagcttc acagtagact gcagcaaagc aggcaacaac     7740

atgctgctgg tgggggttca tggcccaagg accccctgcg aggagatcct ggtgaagcac     7800

gtgggcagcc ggctctacag cgtgtcctac ctgctcaagg acaaggggga gtacacactg     7860

gtggtcaaat ggggggacga gcacatccca ggcagcccct accgcgttgt ggtgccctga     7920


<210> 3
<211> 2647
<212> PRT
<213> Homo sapiens


<220> 
<223> filamin-A isoform 2 modified

<400> 3
Met Ser Ser Ser His Ser Arg Ala Gly Gln Ser Ala Ala Gly Ala Ala 
1               5                   10                  15      
Pro Gly Gly Gly Val Asp Thr Arg Asp Ala Glu Met Pro Ala Thr Glu 
            20                  25                  30          
Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys Ile Gln Gln Asn Thr 
        35                  40                  45              
Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys Val Ser Lys Arg Ile 
    50                  55                  60                  
Ala Asn Leu Gln Thr Asp Leu Ser Asp Gly Leu Arg Leu Ile Ala Leu 
65                  70                  75                  80  
Leu Glu Val Leu Ser Gln Lys Lys Met His Arg Lys His Asn Gln Arg 
                85                  90                  95      
Pro Thr Phe Arg Gln Met Gln Leu Glu Asn Val Ser Val Ala Leu Glu 
            100                 105                 110         
Phe Leu Asp Arg Glu Ser Ile Lys Leu Val Ser Ile Asp Ser Lys Ala 
        115                 120                 125             
Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly Leu Ile Trp Thr Leu 
    130                 135                 140                 
Ile Leu His Tyr Ser Ile Ser Met Pro Met Trp Asp Glu Glu Glu Asp 
145                 150                 155                 160 
Glu Glu Ala Lys Lys Gln Thr Pro Lys Gln Arg Leu Leu Gly Trp Ile 
                165                 170                 175     
Gln Asn Lys Leu Pro Gln Leu Pro Ile Thr Asn Phe Ser Arg Asp Trp 
            180                 185                 190         
Gln Ser Gly Arg Ala Leu Gly Ala Leu Val Asp Ser Cys Ala Pro Gly 
        195                 200                 205             
Leu Cys Pro Asp Trp Asp Ser Trp Asp Ala Ser Lys Pro Val Thr Asn 
    210                 215                 220                 
Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp Leu Gly Ile Pro Gln 
225                 230                 235                 240 
Val Ile Thr Pro Glu Glu Ile Val Asp Pro Asn Val Asp Glu His Ser 
                245                 250                 255     
Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala Lys Leu Lys Pro Gly 
            260                 265                 270         
Ala Pro Leu Arg Pro Lys Leu Asn Pro Lys Lys Ala Arg Ala Tyr Gly 
        275                 280                 285             
Pro Gly Ile Glu Pro Thr Gly Asn Met Val Lys Lys Arg Ala Glu Phe 
    290                 295                 300                 
Thr Val Glu Thr Arg Ser Ala Gly Gln Gly Glu Val Leu Val Tyr Val 
305                 310                 315                 320 
Glu Asp Pro Ala Gly His Gln Glu Glu Ala Lys Val Thr Ala Asn Asn 
                325                 330                 335     
Asp Lys Asn Arg Thr Phe Ser Val Trp Tyr Val Pro Glu Val Thr Gly 
            340                 345                 350         
Thr His Lys Val Thr Val Leu Phe Ala Gly Gln His Ile Ala Lys Ser 
        355                 360                 365             
Pro Phe Glu Val Tyr Val Asp Lys Ser Gln Gly Asp Ala Ser Lys Val 
    370                 375                 380                 
Thr Ala Gln Gly Pro Gly Leu Glu Pro Ser Gly Asn Ile Ala Asn Lys 
385                 390                 395                 400 
Thr Thr Tyr Phe Glu Ile Phe Thr Ala Gly Ala Gly Thr Gly Glu Val 
                405                 410                 415     
Glu Val Val Ile Gln Asp Pro Met Gly Gln Lys Gly Thr Val Glu Pro 
            420                 425                 430         
Gln Leu Glu Ala Arg Gly Asp Ser Thr Tyr Arg Cys Ser Tyr Gln Pro 
        435                 440                 445             
Thr Met Glu Gly Val His Thr Val His Val Thr Phe Ala Gly Val Pro 
    450                 455                 460                 
Ile Pro Arg Ser Pro Tyr Thr Val Thr Val Gly Gln Ala Cys Asn Pro 
465                 470                 475                 480 
Ser Ala Cys Arg Ala Val Gly Arg Gly Leu Gln Pro Lys Gly Val Arg 
                485                 490                 495     
Val Lys Glu Thr Ala Asp Phe Lys Val Tyr Thr Lys Gly Ala Gly Ser 
            500                 505                 510         
Gly Glu Leu Lys Val Thr Val Lys Gly Pro Lys Gly Glu Glu Arg Val 
        515                 520                 525             
Lys Gln Lys Asp Leu Gly Asp Gly Val Tyr Gly Phe Glu Tyr Tyr Pro 
    530                 535                 540                 
Met Val Pro Gly Thr Tyr Ile Val Thr Ile Thr Trp Gly Gly Gln Asn 
545                 550                 555                 560 
Ile Gly Arg Ser Pro Phe Glu Val Lys Val Gly Thr Glu Cys Gly Asn 
                565                 570                 575     
Gln Lys Val Arg Ala Trp Gly Pro Gly Leu Glu Gly Gly Val Val Gly 
            580                 585                 590         
Lys Ser Ala Asp Phe Val Val Glu Ala Ile Gly Asp Asp Val Gly Thr 
        595                 600                 605             
Leu Gly Phe Ser Val Glu Gly Pro Ser Gln Ala Lys Ile Glu Cys Asp 
    610                 615                 620                 
Asp Lys Gly Asp Gly Ser Cys Asp Val Arg Tyr Trp Pro Gln Glu Ala 
625                 630                 635                 640 
Gly Glu Tyr Ala Val His Val Leu Cys Asn Ser Glu Asp Ile Arg Leu 
                645                 650                 655     
Ser Pro Phe Met Ala Asp Ile Arg Asp Ala Pro Gln Asp Phe His Pro 
            660                 665                 670         
Asp Arg Val Lys Ala Arg Gly Pro Gly Leu Glu Lys Thr Gly Val Ala 
        675                 680                 685             
Val Asn Lys Pro Ala Glu Phe Thr Val Asp Ala Lys His Gly Gly Lys 
    690                 695                 700                 
Ala Pro Leu Arg Val Gln Val Gln Asp Asn Glu Gly Cys Pro Val Glu 
705                 710                 715                 720 
Ala Leu Val Lys Asp Asn Gly Asn Gly Thr Tyr Ser Cys Ser Tyr Val 
                725                 730                 735     
Pro Arg Lys Pro Val Lys His Thr Ala Met Val Ser Trp Gly Gly Val 
            740                 745                 750         
Ser Ile Pro Asn Ser Pro Phe Arg Val Asn Val Gly Ala Gly Ser His 
        755                 760                 765             
Pro Asn Lys Val Lys Val Tyr Gly Pro Gly Val Ala Lys Thr Gly Leu 
    770                 775                 780                 
Lys Ala His Glu Pro Thr Tyr Phe Thr Val Asp Cys Ala Glu Ala Gly 
785                 790                 795                 800 
Gln Gly Asp Val Ser Ile Gly Ile Lys Cys Ala Pro Gly Val Val Gly 
                805                 810                 815     
Pro Ala Glu Ala Asp Ile Asp Phe Asp Ile Ile Arg Asn Asp Asn Asp 
            820                 825                 830         
Thr Phe Thr Val Lys Tyr Thr Pro Arg Gly Ala Gly Ser Tyr Thr Ile 
        835                 840                 845             
Met Val Leu Phe Ala Asp Gln Ala Thr Pro Thr Ser Pro Ile Arg Val 
    850                 855                 860                 
Lys Val Glu Pro Ser His Asp Ala Ser Lys Val Lys Ala Glu Gly Pro 
865                 870                 875                 880 
Gly Leu Ser Arg Thr Gly Val Glu Leu Gly Lys Pro Thr His Phe Thr 
                885                 890                 895     
Val Asn Ala Lys Ala Ala Gly Lys Gly Lys Leu Asp Val Gln Phe Ser 
            900                 905                 910         
Gly Leu Thr Lys Gly Asp Ala Val Arg Asp Val Asp Ile Ile Asp His 
        915                 920                 925             
His Asp Asn Thr Tyr Thr Val Lys Tyr Thr Pro Val Gln Gln Gly Pro 
    930                 935                 940                 
Val Gly Val Asn Val Thr Tyr Gly Gly Asp Pro Ile Pro Lys Ser Pro 
945                 950                 955                 960 
Phe Ser Val Ala Val Ser Pro Ser Leu Asp Leu Ser Lys Ile Lys Val 
                965                 970                 975     
Ser Gly Leu Gly Glu Lys Val Asp Val Gly Lys Asp Gln Glu Phe Thr 
            980                 985                 990         
Val Lys Ser Lys Gly Ala Gly Gly Gln Gly Lys Val Ala Ser Lys Ile 
        995                 1000                1005            
Val Gly Pro Ser Gly Ala Ala Val Pro Cys Lys Val Glu Pro Gly Leu 
    1010                1015                1020                
Gly Ala Asp Asn Ser Val Val Arg Phe Leu Pro Arg Glu Glu Gly Pro 
1025                1030                1035                1040
Tyr Glu Val Glu Val Thr Tyr Asp Gly Val Pro Val Pro Gly Ser Pro 
                1045                1050                1055    
Phe Pro Leu Glu Ala Val Ala Pro Thr Lys Pro Ser Lys Val Lys Ala 
            1060                1065                1070        
Phe Gly Pro Gly Leu Gln Gly Gly Ser Ala Gly Ser Pro Ala Arg Phe 
        1075                1080                1085            
Thr Ile Asp Thr Lys Gly Ala Gly Thr Gly Gly Leu Gly Leu Thr Val 
    1090                1095                1100                
Glu Gly Pro Cys Glu Ala Gln Leu Glu Cys Leu Asp Asn Gly Asp Gly 
1105                1110                1115                1120
Thr Cys Ser Val Ser Tyr Val Pro Thr Glu Pro Gly Asp Tyr Asn Ile 
                1125                1130                1135    
Asn Ile Leu Phe Ala Asp Thr His Ile Pro Gly Ser Pro Phe Lys Ala 
            1140                1145                1150        
His Val Val Pro Cys Phe Asp Ala Ser Lys Val Lys Cys Ser Gly Pro 
        1155                1160                1165            
Gly Leu Glu Arg Ala Thr Ala Gly Glu Val Gly Gln Phe Gln Val Asp 
    1170                1175                1180                
Cys Ser Ser Ala Gly Ser Ala Glu Leu Thr Ile Glu Ile Cys Ser Glu 
1185                1190                1195                1200
Ala Gly Leu Pro Ala Glu Val Tyr Ile Gln Asp His Gly Asp Gly Thr 
                1205                1210                1215    
His Thr Ile Thr Tyr Ile Pro Leu Cys Pro Gly Ala Tyr Thr Val Thr 
            1220                1225                1230        
Ile Lys Tyr Gly Gly Gln Pro Val Pro Asn Phe Pro Ser Lys Leu Gln 
        1235                1240                1245            
Val Glu Pro Ala Val Asp Thr Ser Gly Val Gln Cys Tyr Gly Pro Gly 
    1250                1255                1260                
Ile Glu Gly Gln Gly Val Phe Arg Glu Ala Thr Thr Glu Phe Ser Val 
1265                1270                1275                1280
Asp Ala Arg Ala Leu Thr Gln Thr Gly Gly Pro His Val Lys Ala Arg 
                1285                1290                1295    
Val Ala Asn Pro Ser Gly Asn Leu Thr Glu Thr Tyr Val Gln Asp Arg 
            1300                1305                1310        
Gly Asp Gly Met Tyr Lys Val Glu Tyr Thr Pro Tyr Glu Glu Gly Leu 
        1315                1320                1325            
His Ser Val Asp Val Thr Tyr Asp Gly Ser Pro Val Pro Ser Ser Pro 
    1330                1335                1340                
Phe Gln Val Pro Val Thr Glu Gly Cys Asp Pro Ser Arg Val Arg Val 
1345                1350                1355                1360
His Gly Pro Gly Ile Gln Ser Gly Thr Thr Asn Lys Pro Asn Lys Phe 
                1365                1370                1375    
Thr Val Glu Thr Arg Gly Ala Gly Thr Gly Gly Leu Gly Leu Ala Val 
            1380                1385                1390        
Glu Gly Pro Ser Glu Ala Lys Met Ser Cys Met Asp Asn Lys Asp Gly 
        1395                1400                1405            
Ser Cys Ser Val Glu Tyr Ile Pro Tyr Glu Ala Gly Thr Tyr Ser Leu 
    1410                1415                1420                
Asn Val Thr Tyr Gly Gly His Gln Val Pro Gly Ser Pro Phe Lys Val 
1425                1430                1435                1440
Pro Val His Asp Val Thr Asp Ala Ser Lys Val Lys Cys Ser Gly Pro 
                1445                1450                1455    
Gly Leu Ser Pro Gly Met Val Arg Ala Asn Leu Pro Gln Ser Phe Gln 
            1460                1465                1470        
Val Asp Thr Ser Lys Ala Gly Val Ala Pro Leu Gln Val Lys Val Gln 
        1475                1480                1485            
Gly Pro Lys Gly Leu Val Glu Pro Val Asp Val Val Asp Asn Ala Asp 
    1490                1495                1500                
Gly Thr Gln Thr Val Asn Tyr Val Pro Ser Arg Glu Gly Pro Tyr Ser 
1505                1510                1515                1520
Ile Ser Val Leu Tyr Gly Asp Glu Glu Val Pro Arg Ser Pro Phe Lys 
                1525                1530                1535    
Val Lys Val Leu Pro Thr His Asp Ala Ser Lys Val Lys Ala Ser Gly 
            1540                1545                1550        
Pro Gly Leu Asn Thr Thr Gly Val Pro Ala Ser Leu Pro Val Glu Phe 
        1555                1560                1565            
Thr Ile Asp Ala Lys Asp Ala Gly Glu Gly Leu Leu Ala Val Gln Ile 
    1570                1575                1580                
Thr Asp Pro Glu Gly Lys Pro Lys Lys Thr His Ile Gln Asp Asn His 
1585                1590                1595                1600
Asp Gly Thr Tyr Thr Val Ala Tyr Val Pro Asp Val Thr Gly Arg Tyr 
                1605                1610                1615    
Thr Ile Leu Ile Lys Tyr Gly Gly Asp Glu Ile Pro Phe Ser Pro Tyr 
            1620                1625                1630        
Arg Val Arg Ala Val Pro Thr Gly Asp Ala Ser Lys Cys Thr Val Thr 
        1635                1640                1645            
Val Ser Ile Gly Gly His Gly Leu Gly Ala Gly Ile Gly Pro Thr Ile 
    1650                1655                1660                
Gln Ile Gly Glu Glu Thr Val Ile Thr Val Asp Thr Lys Ala Ala Gly 
1665                1670                1675                1680
Lys Gly Lys Val Thr Cys Thr Val Cys Thr Pro Asp Gly Ser Glu Val 
                1685                1690                1695    
Asp Val Asp Val Val Glu Asn Glu Asp Gly Thr Phe Asp Ile Phe Tyr 
            1700                1705                1710        
Thr Ala Pro Gln Pro Gly Lys Tyr Val Ile Cys Val Arg Phe Gly Gly 
        1715                1720                1725            
Glu His Val Pro Asn Ser Pro Phe Gln Val Thr Ala Leu Ala Gly Asp 
    1730                1735                1740                
Gln Pro Ser Val Gln Pro Pro Leu Arg Ser Gln Gln Leu Ala Pro Gln 
1745                1750                1755                1760
Tyr Thr Tyr Ala Gln Gly Gly Gln Gln Thr Trp Ala Pro Glu Arg Pro 
                1765                1770                1775    
Leu Val Gly Val Asn Gly Leu Asp Val Thr Ser Leu Arg Pro Phe Asp 
            1780                1785                1790        
Leu Val Ile Pro Phe Thr Ile Lys Lys Gly Glu Ile Thr Gly Glu Val 
        1795                1800                1805            
Arg Met Pro Ser Gly Lys Val Ala Gln Pro Thr Ile Thr Asp Asn Lys 
    1810                1815                1820                
Asp Gly Thr Val Thr Val Arg Tyr Ala Pro Ser Glu Ala Gly Leu His 
1825                1830                1835                1840
Glu Met Asp Ile Arg Tyr Asp Asn Met His Ile Pro Gly Ser Pro Leu 
                1845                1850                1855    
Gln Phe Tyr Val Asp Tyr Val Asn Cys Gly His Val Thr Ala Tyr Gly 
            1860                1865                1870        
Pro Gly Leu Thr His Gly Val Val Asn Lys Pro Ala Thr Phe Thr Val 
        1875                1880                1885            
Asn Thr Lys Asp Ala Gly Glu Gly Gly Leu Ser Leu Ala Ile Glu Gly 
    1890                1895                1900                
Pro Ser Lys Ala Glu Ile Ser Cys Thr Asp Asn Gln Asp Gly Thr Cys 
1905                1910                1915                1920
Ser Val Ser Tyr Leu Pro Val Leu Pro Gly Asp Tyr Ser Ile Leu Val 
                1925                1930                1935    
Lys Tyr Asn Glu Gln His Val Pro Gly Ser Pro Phe Thr Ala Arg Val 
            1940                1945                1950        
Thr Gly Asp Asp Ser Met Arg Met Ser His Leu Lys Val Gly Ser Ala 
        1955                1960                1965            
Ala Asp Ile Pro Ile Asn Ile Ser Glu Thr Asp Leu Ser Leu Leu Thr 
    1970                1975                1980                
Ala Thr Val Val Pro Pro Ser Gly Arg Glu Glu Pro Cys Leu Leu Lys 
1985                1990                1995                2000
Arg Leu Arg Asn Gly His Val Gly Ile Ser Phe Val Pro Lys Glu Thr 
                2005                2010                2015    
Gly Glu His Leu Val His Val Lys Lys Asn Gly Gln His Val Ala Ser 
            2020                2025                2030        
Ser Pro Ile Pro Val Val Ile Ser Gln Ser Glu Ile Gly Asp Ala Ser 
        2035                2040                2045            
Arg Val Arg Val Ser Gly Gln Gly Leu His Glu Gly His Thr Phe Glu 
    2050                2055                2060                
Pro Ala Glu Phe Ile Ile Asp Thr Arg Asp Ala Gly Tyr Gly Gly Leu 
2065                2070                2075                2080
Ser Leu Ser Ile Glu Gly Pro Ser Lys Val Asp Ile Asn Thr Glu Asp 
                2085                2090                2095    
Leu Glu Asp Gly Thr Cys Arg Val Thr Tyr Cys Pro Thr Glu Pro Gly 
            2100                2105                2110        
Asn Tyr Ile Ile Asn Ile Lys Phe Ala Asp Gln His Val Pro Gly Ser 
        2115                2120                2125            
Pro Phe Ser Val Lys Val Thr Gly Glu Gly Arg Val Lys Glu Ser Ile 
    2130                2135                2140                
Thr Arg Arg Arg Arg Ala Pro Ser Val Ala Asn Val Gly Ser His Cys 
2145                2150                2155                2160
Asp Leu Ser Leu Lys Ile Pro Glu Ile Ser Ile Gln Asp Met Thr Ala 
                2165                2170                2175    
Gln Val Thr Ser Pro Ser Gly Lys Thr His Glu Ala Glu Ile Val Glu 
            2180                2185                2190        
Gly Glu Asn His Thr Tyr Cys Ile Arg Phe Val Pro Ala Glu Met Gly 
        2195                2200                2205            
Thr His Thr Val Ser Val Lys Tyr Lys Gly Gln His Val Pro Gly Ser 
    2210                2215                2220                
Pro Phe Gln Phe Thr Val Gly Pro Leu Gly Glu Gly Gly Ala His Lys 
2225                2230                2235                2240
Val Arg Ala Gly Gly Pro Gly Leu Glu Arg Ala Glu Ala Gly Val Pro 
                2245                2250                2255    
Ala Glu Phe Ser Ile Trp Thr Arg Glu Ala Gly Ala Gly Gly Leu Ala 
            2260                2265                2270        
Ile Ala Val Glu Gly Pro Ser Lys Ala Glu Ile Ser Phe Glu Asp Arg 
        2275                2280                2285            
Lys Asp Gly Ser Cys Gly Val Ala Tyr Val Val Gln Glu Pro Gly Asp 
    2290                2295                2300                
Tyr Glu Val Ser Val Lys Phe Asn Glu Glu His Ile Pro Asp Ser Pro 
2305                2310                2315                2320
Phe Val Val Pro Val Ala Ser Pro Ser Gly Asp Ala Arg Arg Leu Thr 
                2325                2330                2335    
Val Ser Ser Leu Arg Glu Ser Gly Leu Lys Val Asn Gln Pro Ala Ser 
            2340                2345                2350        
Phe Ala Val Ser Leu Asn Gly Ala Lys Gly Ala Ile Asp Ala Lys Val 
        2355                2360                2365            
His Ser Pro Ser Gly Ala Leu Glu Glu Cys Tyr Val Thr Glu Ile Asp 
    2370                2375                2380                
Gln Asp Lys Tyr Ala Val Arg Phe Ile Pro Arg Glu Asn Gly Val Tyr 
2385                2390                2395                2400
Leu Ile Asp Val Lys Phe Asn Gly Thr His Ile Pro Gly Ser Pro Phe 
                2405                2410                2415    
Lys Ile Arg Val Gly Glu Pro Gly His Gly Gly Asp Pro Gly Leu Val 
            2420                2425                2430        
Ser Ala Tyr Gly Ala Gly Leu Glu Gly Gly Val Thr Gly Asn Pro Ala 
        2435                2440                2445            
Glu Phe Val Val Asn Thr Ser Asn Ala Gly Ala Gly Ala Leu Ser Val 
    2450                2455                2460                
Thr Ile Asp Gly Pro Ser Lys Val Lys Met Asp Cys Gln Glu Cys Pro 
2465                2470                2475                2480
Glu Gly Tyr Arg Val Thr Tyr Thr Pro Met Ala Pro Gly Ser Tyr Leu 
                2485                2490                2495    
Ile Ser Ile Lys Tyr Gly Gly Pro Tyr His Ile Gly Gly Ser Pro Phe 
            2500                2505                2510        
Lys Ala Lys Val Thr Gly Pro Arg Leu Val Ser Asn His Ser Leu His 
        2515                2520                2525            
Glu Thr Ser Ser Val Phe Val Asp Ser Leu Thr Lys Ala Thr Cys Ala 
    2530                2535                2540                
Pro Gln His Gly Ala Pro Gly Pro Gly Pro Ala Asp Ala Ser Lys Val 
2545                2550                2555                2560
Val Ala Lys Gly Leu Gly Leu Ser Lys Ala Tyr Val Gly Gln Lys Ser 
                2565                2570                2575    
Ser Phe Thr Val Asp Cys Ser Lys Ala Gly Asn Asn Met Leu Leu Val 
            2580                2585                2590        
Gly Val His Gly Pro Arg Thr Pro Cys Glu Glu Ile Leu Val Lys His 
        2595                2600                2605            
Val Gly Ser Arg Leu Tyr Ser Val Ser Tyr Leu Leu Lys Asp Lys Gly 
    2610                2615                2620                
Glu Tyr Thr Leu Val Val Lys Trp Gly Asp Glu His Ile Pro Gly Ser 
2625                2630                2635                2640
Pro Tyr Arg Val Val Val Pro 
                2645        

<210> 4
<211> 7944
<212> DNA
<213> Homo sapiens


<220> 
<223> filamin A isoform 2 modified

<400> 4
atgagtagct cccactctcg ggcgggccag agcgcagcag gcgcggctcc gggcggcggc       60

gtcgacacgc gggacgccga gatgccggcc accgagaagg acctggcgga ggacgcgccg      120

tggaagaaga tccagcagaa cactttcacg cgctggtgca acgagcacct gaagtgcgtg      180

agcaagcgca tcgccaacct gcagacggac ctgagcgacg ggctgcggct tatcgcgctg      240

ttggaggtgc tcagccagaa gaagatgcac cgcaagcaca accagcggcc cactttccgc      300

caaatgcagc ttgagaacgt gtcggtggcg ctcgagttcc tggaccgcga gagcatcaaa      360

ctggtgtcca tcgacagcaa ggccatcgtg gacgggaacc tgaagctgat cctgggcctc      420

atctggaccc tgatcctgca ctactccatc tccatgccca tgtgggacga ggaggaggat      480

gaggaggcca agaagcagac ccccaagcag aggctcctgg gctggatcca gaacaagctg      540

ccgcagctgc ccatcaccaa cttcagccgg gactggcaga gcggccgggc cctgggcgcc      600

ctggtggaca gctgtgcccc gggcctgtgt cctgactggg actcttggga cgccagcaag      660

cccgttacca atgcgcgaga ggccatgcag caggcggatg actggctggg catcccccag      720

gtgatcaccc ccgaggagat tgtggacccc aacgtggacg agcactctgt catgacctac      780

ctgtcccagt tccccaaggc caagctgaag ccaggggctc ccttgcggcc caaactgaac      840

ccgaagaaag cccgtgccta cgggccaggc atcgagccca caggcaacat ggtgaagaag      900

cgggcagagt tcactgtgga gaccagaagt gctggccagg gagaggtgct ggtgtacgtg      960

gaggacccgg ccggacacca ggaggaggca aaagtgaccg ccaataacga caagaaccgc     1020

accttctccg tctggtacgt ccccgaggtg acggggactc ataaggttac tgtgctcttt     1080

gctggccagc acatcgccaa gagccccttc gaggtgtacg tggataagtc acagggtgac     1140

gccagcaaag tgacagccca aggtcccggc ctggagccca gtggcaacat cgccaacaag     1200

accacctact ttgagatctt tacggcagga gctggcacgg gcgaggtcga ggttgtgatc     1260

caggacccca tgggacagaa gggcacggta gagcctcagc tggaggcccg gggcgacagc     1320

acataccgct gcagctacca gcccaccatg gagggcgtcc acaccgtgca cgtcacgttt     1380

gccggcgtgc ccatccctcg cagcccctac actgtcactg ttggccaagc ctgtaacccg     1440

agtgcctgcc gggcggttgg ccggggcctc cagcccaagg gtgtgcgggt gaaggagaca     1500

gctgacttca aggtgtacac aaagggcgct ggcagtgggg agctgaaggt caccgtgaag     1560

ggccccaagg gagaggagcg cgtgaagcag aaggacctgg gggatggcgt gtatggcttc     1620

gagtattacc ccatggtccc tggaacctat atcgtcacca tcacgtgggg tggtcagaac     1680

atcgggcgca gtcccttcga agtgaaggtg ggcaccgagt gtggcaatca gaaggtacgg     1740

gcctggggcc ctgggctgga gggcggcgtc gttggcaagt cagcagactt tgtggtggag     1800

gctatcgggg acgacgtggg cacgctgggc ttctcggtgg aagggccatc gcaggctaag     1860

atcgaatgtg acgacaaggg cgacggctcc tgtgatgtgc gctactggcc gcaggaggct     1920

ggcgagtatg ccgttcacgt gctgtgcaac agcgaagaca tccgcctcag ccccttcatg     1980

gctgacatcc gtgacgcgcc ccaggacttc cacccagaca gggtgaaggc acgtgggcct     2040

ggattggaga agacaggtgt ggccgtcaac aagccagcag agttcacagt ggatgccaag     2100

cacggtggca aggccccact tcgggtccaa gtccaggaca atgaaggctg ccctgtggag     2160

gcgttggtca aggacaacgg caatggcact tacagctgct cctacgtgcc caggaagccg     2220

gtgaagcaca cagccatggt gtcctgggga ggcgtcagca tccccaacag ccccttcagg     2280

gtgaatgtgg gagctggcag ccaccccaac aaggtcaaag tatacggccc cggagtagcc     2340

aagacagggc tcaaggccca cgagcccacc tacttcactg tggactgcgc cgaggctggc     2400

cagggggacg tcagcatcgg catcaagtgt gcccctggag tggtaggccc cgccgaagct     2460

gacatcgact tcgacatcat ccgcaatgac aatgacacct tcacggtcaa gtacacgccc     2520

cggggggctg gcagctacac cattatggtc ctctttgctg accaggccac gcccaccagc     2580

cccatccgag tcaaggtgga gccctctcat gacgccagta aggtgaaggc cgagggccct     2640

ggcctcagtc gcactggtgt cgagcttggc aagcccaccc acttcacagt aaatgccaaa     2700

gctgctggca aaggcaagct ggacgtccag ttctcaggac tcaccaaggg ggatgcagtg     2760

cgagatgtgg acatcatcga ccaccatgac aacacctaca cagtcaagta cacgcctgtc     2820

cagcagggtc cagtaggcgt caatgtcact tatggagggg atcccatccc taagagccct     2880

ttctcagtgg cagtatctcc aagcctggac ctcagcaaga tcaaggtgtc tggcctggga     2940

gagaaggtgg acgttggcaa agaccaggag ttcacagtca aatcaaaggg tgctggtggt     3000

caaggcaaag tggcatccaa gattgtgggc ccctcgggtg cagcggtgcc ctgcaaggtg     3060

gagccaggcc tgggggctga caacagtgtg gtgcgcttcc tgccccgtga ggaagggccc     3120

tatgaggtgg aggtgaccta tgacggcgtg cccgtgcctg gcagcccctt tcctctggaa     3180

gctgtggccc ccaccaagcc tagcaaggtg aaggcgtttg ggccggggct gcagggaggc     3240

agtgcgggct cccccgcccg cttcaccatc gacaccaagg gcgccggcac aggtggcctg     3300

ggcctgacgg tggagggccc ctgtgaggcg cagctcgagt gcttggacaa tggggatggc     3360

acatgttccg tgtcctacgt gcccaccgag cccggggact acaacatcaa catcctcttc     3420

gctgacaccc acatccctgg ctccccattc aaggcccacg tggttccctg ctttgacgca     3480

tccaaagtca agtgctcagg ccccgggctg gagcgggcca ccgctgggga ggtgggccaa     3540

ttccaagtgg actgctcgag cgcgggcagc gcggagctga ccattgagat ctgctcggag     3600

gcggggcttc cggccgaggt gtacatccag gaccacggtg atggcacgca caccattacc     3660

tacattcccc tctgccccgg ggcctacacc gtcaccatca agtacggcgg ccagcccgtg     3720

cccaacttcc ccagcaagct gcaggtggaa cctgcggtgg acacttccgg tgtccagtgc     3780

tatgggcctg gtattgaggg ccagggtgtc ttccgtgagg ccaccactga gttcagtgtg     3840

gacgcccggg ctctgacaca gaccggaggg ccgcacgtca aggcccgtgt ggccaacccc     3900

tcaggcaacc tgacggagac ctacgttcag gaccgtggcg atggcatgta caaagtggag     3960

tacacgcctt acgaggaggg actgcactcc gtggacgtga cctatgacgg cagtcccgtg     4020

cccagcagcc ccttccaggt gcccgtgacc gagggctgcg acccctcccg ggtgcgtgtc     4080

cacgggccag gcatccaaag tggcaccacc aacaagccca acaagttcac tgtggagacc     4140

aggggagctg gcacgggcgg cctgggcctg gctgtagagg gcccctccga ggccaagatg     4200

tcctgcatgg ataacaagga cggcagctgc tcggtcgagt acatccctta tgaggctggc     4260

acctacagcc tcaacgtcac ctatggtggc catcaagtgc caggcagtcc tttcaaggtc     4320

cctgtgcatg atgtgacaga tgcgtccaag gtcaagtgct ctgggcccgg cctgagccca     4380

ggcatggttc gtgccaacct ccctcagtcc ttccaggtgg acacaagcaa ggctggtgtg     4440

gccccattgc aggtcaaagt gcaagggccc aaaggcctgg tggagccagt ggacgtggta     4500

gacaacgctg atggcaccca gaccgtcaat tatgtgccca gccgagaagg gccctacagc     4560

atctcagtac tgtatggaga tgaagaggta ccccggagcc ccttcaaggt caaggtgctg     4620

cctactcatg atgccagcaa ggtgaaggcc agtggccccg ggctcaacac cactggcgtg     4680

cctgccagcc tgcccgtgga gttcaccatc gatgcaaagg acgccgggga gggcctgctg     4740

gctgtccaga tcacggatcc cgaaggcaag ccgaagaaga cacacatcca agacaaccat     4800

gacggcacgt atacagtggc ctacgtgcca gacgtgacag gtcgctacac catcctcatc     4860

aagtacggtg gtgacgagat ccccttctcc ccgtaccgcg tgcgtgccgt gcccaccggg     4920

gacgccagca agtgcactgt cacagtgtca atcggaggtc acgggctagg tgctggcatc     4980

ggccccacca ttcagattgg ggaggagacg gtgatcactg tggacactaa ggcggcaggc     5040

aaaggcaaag tgacgtgcac cgtgtgcacg cctgatggct cagaggtgga tgtggacgtg     5100

gtggagaatg aggacggcac tttcgacatc ttctacacgg ccccccagcc gggcaaatac     5160

gtcatctgtg tgcgctttgg tggcgagcac gtgcccaaca gccccttcca agtgacggct     5220

ctggctgggg accagccctc ggtgcagccc cctctacggt ctcagcagct ggccccacag     5280

tacacctacg cccagggcgg ccagcagact tgggccccgg agaggcccct ggtgggtgtc     5340

aatgggctgg atgtgaccag cctgaggccc tttgaccttg tcatcccctt caccatcaag     5400

aagggcgaga tcacagggga ggttcggatg ccctcaggca aggtggcgca gcccaccatc     5460

actgacaaca aagacggcac cgtgaccgtg cggtatgcac ccagcgaggc tggcctgcac     5520

gagatggaca tccgctatga caacatgcac atcccaggaa gccccttgca gttctatgtg     5580

gattacgtca actgtggcca tgtcactgcc tatgggcctg gcctcaccca tggagtagtg     5640

aacaagcctg ccaccttcac cgtcaacacc aaggatgcag gagagggggg cctgtctctg     5700

gccattgagg gcccgtccaa agcagaaatc agctgcactg acaaccagga tgggacatgc     5760

agcgtgtcct acctgcctgt gctgccgggg gactacagca ttctagtcaa gtacaatgaa     5820

cagcacgtcc caggcagccc cttcactgct cgggtcacag gtgacgactc catgcgtatg     5880

tcccacctaa aggtcggctc tgctgccgac atccccatca acatctcaga gacggatctc     5940

agcctgctga cggccactgt ggtcccgccc tcgggccggg aggagccctg tttgctgaag     6000

cggctgcgta atggccacgt ggggatttca ttcgtgccca aggagacggg ggagcacctg     6060

gtgcatgtga agaaaaatgg ccagcacgtg gccagcagcc ccatcccggt ggtgatcagc     6120

cagtcggaaa ttggggatgc cagtcgtgtt cgggtctctg gtcagggcct tcacgaaggc     6180

cacacctttg agcctgcaga gtttatcatt gatacccgcg atgcaggcta tggtgggctc     6240

agcctgtcca ttgagggccc cagcaaggtg gacatcaaca cagaggacct ggaggacggg     6300

acgtgcaggg tcacctactg ccccacagag ccaggcaact acatcatcaa catcaagttt     6360

gccgaccagc acgtgcctgg cagccccttc tctgtgaagg tgacaggcga gggccgggtg     6420

aaagagagca tcacccgcag gcgtcgggct ccttcagtgg ccaacgttgg tagtcattgt     6480

gacctcagcc tgaaaatccc tgaaattagc atccaggata tgacagccca ggtgaccagc     6540

ccatcgggca agacccatga ggccgagatc gtggaagggg agaaccacac ctactgcatc     6600

cgctttgttc ccgctgagat gggcacacac acagtcagcg tgaagtacaa gggccagcac     6660

gtgcctggga gccccttcca gttcaccgtg gggcccctag gggaaggggg agcccacaag     6720

gtccgagctg ggggccctgg cctggagaga gctgaagctg gagtgccagc cgaattcagt     6780

atctggaccc gggaagctgg tgctggaggc ctggccattg ctgtcgaggg ccccagcaag     6840

gctgagatct cttttgagga ccgcaaggac ggctcctgtg gtgtggctta tgtggtccag     6900

gagccaggtg actacgaagt ctcagtcaag ttcaacgagg aacacattcc cgacagcccc     6960

ttcgtggtgc ctgtggcttc tccgtctggc gacgcccgcc gcctcactgt ttctagcctt     7020

cgggagtcag ggctaaaggt caaccagcca gcctcttttg cagtcagcct gaacggggcc     7080

aagggggcga tcgatgccaa ggtgcacagc ccctcaggag ccctggagga gtgctatgtc     7140

acagaaattg accaagataa gtatgctgtg cgcttcatcc ctcgggagaa tggcgtttac     7200

ctgattgacg tcaagttcaa cggcacccac atccctggaa gccccttcaa gatccgagtt     7260

ggggagcctg ggcatggagg ggacccaggc ttggtgtctg cttacggagc aggtctggaa     7320

ggcggtgtca cagggaaccc agctgagttc gtcgtgaaca cgagcaatgc gggagctggt     7380

gccctgtcgg tgaccattga cggcccctcc aaggtgaaga tggattgcca ggagtgccct     7440

gagggctacc gcgtcaccta tacccccatg gcacctggca gctacctcat ctccatcaag     7500

tacggcggcc cctaccacat tgggggcagc cccttcaagg ccaaagtcac aggcccccgt     7560

ctcgtcagca accacagcct ccacgagaca tcatcagtgt ttgtagactc tctgaccaag     7620

gccacctgtg ccccccagca tggggccccg ggtcctgggc ctgctgacgc cagcaaggtg     7680

gtggccaagg gcctggggct gagcaaggcc tacgtaggcc agaagagcag cttcacagta     7740

gactgcagca aagcaggcaa caacatgctg ctggtggggg ttcatggccc aaggaccccc     7800

tgcgaggaga tcctggtgaa gcacgtgggc agccggctct acagcgtgtc ctacctgctc     7860

aaggacaagg gggagtacac actggtggtc aaatgggggg acgagcacat cccaggcagc     7920

ccctaccgcg ttgtggtgcc ctga                                            7944


<210> 5
<211> 2633
<212> PRT
<213> Homo sapiens


<220> 
<223> filamin-B isoform 1 modified

<400> 5
Met Pro Val Thr Glu Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys 
1               5                   10                  15      
Ile Gln Gln Asn Thr Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys 
            20                  25                  30          
Val Asn Lys Arg Ile Gly Asn Leu Gln Thr Asp Leu Ser Asp Gly Leu 
        35                  40                  45              
Arg Leu Ile Ala Leu Leu Glu Val Leu Ser Gln Lys Arg Met Tyr Arg 
    50                  55                  60                  
Lys Tyr His Gln Arg Pro Thr Phe Arg Gln Met Gln Leu Glu Asn Val 
65                  70                  75                  80  
Ser Val Ala Leu Glu Phe Leu Asp Arg Glu Ser Ile Lys Leu Val Ser 
                85                  90                  95      
Ile Asp Ser Lys Ala Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly 
            100                 105                 110         
Leu Val Trp Thr Leu Ile Leu His Tyr Ser Ile Ser Met Pro Val Trp 
        115                 120                 125             
Glu Asp Glu Gly Asp Asp Asp Ala Lys Lys Gln Thr Pro Lys Gln Arg 
    130                 135                 140                 
Leu Leu Gly Trp Ile Gln Asn Lys Ile Pro Tyr Leu Pro Ile Thr Asn 
145                 150                 155                 160 
Phe Asn Gln Asn Trp Gln Asp Gly Lys Ala Leu Gly Ala Leu Val Asp 
                165                 170                 175     
Ser Cys Ala Pro Gly Leu Cys Pro Asp Trp Glu Ser Trp Asp Pro Gln 
            180                 185                 190         
Lys Pro Val Asp Asn Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp 
        195                 200                 205             
Leu Gly Val Pro Gln Val Ile Thr Pro Glu Glu Ile Ile His Pro Asp 
    210                 215                 220                 
Val Asp Glu His Ser Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala 
225                 230                 235                 240 
Lys Leu Lys Pro Gly Ala Pro Leu Lys Pro Lys Leu Asn Pro Lys Lys 
                245                 250                 255     
Ala Arg Ala Tyr Gly Arg Gly Ile Glu Pro Thr Gly Asn Met Val Lys 
            260                 265                 270         
Gln Pro Ala Lys Phe Thr Val Asp Thr Ile Ser Ala Gly Gln Gly Asp 
        275                 280                 285             
Val Met Val Phe Val Glu Asp Pro Glu Gly Asn Lys Glu Glu Ala Gln 
    290                 295                 300                 
Val Thr Pro Asp Ser Asp Lys Asn Lys Thr Tyr Ser Val Glu Tyr Leu 
305                 310                 315                 320 
Pro Lys Val Thr Gly Leu His Lys Val Thr Val Leu Phe Ala Gly Gln 
                325                 330                 335     
His Ile Ser Lys Ser Pro Phe Glu Val Ser Val Asp Lys Ala Gln Gly 
            340                 345                 350         
Asp Ala Ser Lys Val Thr Ala Lys Gly Pro Gly Leu Glu Ala Val Gly 
        355                 360                 365             
Asn Ile Ala Asn Lys Pro Thr Tyr Phe Asp Ile Tyr Thr Ala Gly Ala 
    370                 375                 380                 
Gly Val Gly Asp Ile Gly Val Glu Val Glu Asp Pro Gln Gly Lys Asn 
385                 390                 395                 400 
Thr Val Glu Leu Leu Val Glu Asp Lys Gly Asn Gln Val Tyr Arg Cys 
                405                 410                 415     
Val Tyr Lys Pro Met Gln Pro Gly Pro His Val Val Lys Ile Phe Phe 
            420                 425                 430         
Ala Gly Asp Thr Ile Pro Lys Ser Pro Phe Val Val Gln Val Gly Glu 
        435                 440                 445             
Ala Cys Asn Pro Asn Ala Cys Arg Ala Ser Gly Arg Gly Leu Gln Pro 
    450                 455                 460                 
Lys Gly Val Arg Ile Arg Glu Thr Thr Asp Phe Lys Val Asp Thr Lys 
465                 470                 475                 480 
Ala Ala Gly Ser Gly Glu Leu Gly Val Thr Met Lys Gly Pro Lys Gly 
                485                 490                 495     
Leu Glu Glu Leu Val Lys Gln Lys Asp Phe Leu Asp Gly Val Tyr Ala 
            500                 505                 510         
Phe Glu Tyr Tyr Pro Ser Thr Pro Gly Arg Tyr Ser Ile Ala Ile Thr 
        515                 520                 525             
Trp Gly Gly His His Ile Pro Lys Ser Pro Phe Glu Val Gln Val Gly 
    530                 535                 540                 
Pro Glu Ala Gly Met Gln Lys Val Arg Ala Trp Gly Pro Gly Leu His 
545                 550                 555                 560 
Gly Gly Ile Val Gly Arg Ser Ala Asp Phe Val Val Glu Ser Ile Gly 
                565                 570                 575     
Ser Glu Val Gly Ser Leu Gly Phe Ala Ile Glu Gly Pro Ser Gln Ala 
            580                 585                 590         
Lys Ile Glu Tyr Asn Asp Gln Asn Asp Gly Ser Cys Asp Val Lys Tyr 
        595                 600                 605             
Trp Pro Lys Glu Pro Gly Glu Tyr Ala Val His Ile Met Cys Asp Asp 
    610                 615                 620                 
Glu Asp Ile Lys Asp Ser Pro Tyr Met Ala Phe Ile His Pro Ala Thr 
625                 630                 635                 640 
Gly Gly Tyr Asn Pro Asp Leu Val Arg Ala Tyr Gly Pro Gly Leu Glu 
                645                 650                 655     
Lys Ser Gly Cys Ile Val Asn Asn Leu Ala Glu Phe Thr Val Asp Pro 
            660                 665                 670         
Lys Asp Ala Gly Lys Ala Pro Leu Lys Ile Phe Ala Gln Asp Gly Glu 
        675                 680                 685             
Gly Gln Arg Ile Asp Ile Gln Met Lys Asn Arg Met Asp Gly Thr Tyr 
    690                 695                 700                 
Ala Cys Ser Tyr Thr Pro Val Lys Ala Ile Lys His Thr Ile Ala Val 
705                 710                 715                 720 
Val Trp Gly Gly Val Asn Ile Pro His Ser Pro Tyr Arg Val Asn Ile 
                725                 730                 735     
Gly Gln Gly Ser His Pro Gln Lys Val Lys Val Phe Gly Pro Gly Val 
            740                 745                 750         
Glu Arg Ser Gly Leu Lys Ala Asn Glu Pro Thr His Phe Thr Val Asp 
        755                 760                 765             
Cys Thr Glu Ala Gly Glu Gly Asp Val Ser Val Gly Ile Lys Cys Asp 
    770                 775                 780                 
Ala Arg Val Leu Ser Glu Asp Glu Glu Asp Val Asp Phe Asp Ile Ile 
785                 790                 795                 800 
His Asn Ala Asn Asp Thr Phe Thr Val Lys Tyr Val Pro Pro Ala Ala 
                805                 810                 815     
Gly Arg Tyr Thr Ile Lys Val Leu Phe Ala Ser Gln Glu Ile Pro Ala 
            820                 825                 830         
Ser Pro Phe Arg Val Lys Val Asp Pro Ser His Asp Ala Ser Lys Val 
        835                 840                 845             
Lys Ala Glu Gly Pro Gly Leu Ser Lys Ala Gly Val Glu Asn Gly Lys 
    850                 855                 860                 
Pro Thr His Phe Thr Val Tyr Thr Lys Gly Ala Gly Lys Ala Pro Leu 
865                 870                 875                 880 
Asn Val Gln Phe Asn Ser Pro Leu Pro Gly Asp Ala Val Lys Asp Leu 
                885                 890                 895     
Asp Ile Ile Asp Asn Tyr Asp Tyr Ser His Thr Val Lys Tyr Thr Pro 
            900                 905                 910         
Thr Gln Gln Gly Asn Met Gln Val Leu Val Thr Tyr Gly Gly Asp Pro 
        915                 920                 925             
Ile Pro Lys Ser Pro Phe Thr Val Gly Val Ala Ala Pro Leu Asp Leu 
    930                 935                 940                 
Ser Lys Ile Lys Leu Asn Gly Leu Glu Asn Arg Val Glu Val Gly Lys 
945                 950                 955                 960 
Asp Gln Glu Phe Thr Val Asp Thr Arg Gly Ala Gly Gly Gln Gly Lys 
                965                 970                 975     
Leu Asp Val Thr Ile Leu Ser Pro Ser Arg Lys Val Val Pro Cys Leu 
            980                 985                 990         
Val Thr Pro Val Thr Gly Arg Glu Asn Ser Thr Ala Lys Phe Ile Pro 
        995                 1000                1005            
Arg Glu Glu Gly Leu Tyr Ala Val Asp Val Thr Tyr Asp Gly His Pro 
    1010                1015                1020                
Val Pro Gly Ser Pro Tyr Thr Val Glu Ala Ser Leu Pro Pro Asp Pro 
1025                1030                1035                1040
Ser Lys Val Lys Ala His Gly Pro Gly Leu Glu Gly Gly Leu Val Gly 
                1045                1050                1055    
Lys Pro Ala Glu Phe Thr Ile Asp Thr Lys Gly Ala Gly Thr Gly Gly 
            1060                1065                1070        
Leu Gly Leu Thr Val Glu Gly Pro Cys Glu Ala Lys Ile Glu Cys Ser 
        1075                1080                1085            
Asp Asn Gly Asp Gly Thr Cys Ser Val Ser Tyr Leu Pro Thr Lys Pro 
    1090                1095                1100                
Gly Glu Tyr Phe Val Asn Ile Leu Phe Glu Glu Val His Ile Pro Gly 
1105                1110                1115                1120
Ser Pro Phe Lys Ala Asp Ile Glu Met Pro Phe Asp Pro Ser Lys Val 
                1125                1130                1135    
Val Ala Ser Gly Pro Gly Leu Glu His Gly Lys Val Gly Glu Ala Gly 
            1140                1145                1150        
Leu Leu Ser Val Asp Cys Ser Glu Ala Gly Pro Gly Ala Leu Gly Leu 
        1155                1160                1165            
Glu Ala Val Ser Asp Ser Gly Thr Lys Ala Glu Val Ser Ile Gln Asn 
    1170                1175                1180                
Asn Lys Asp Gly Thr Tyr Ala Val Thr Tyr Val Pro Leu Thr Ala Gly 
1185                1190                1195                1200
Met Tyr Thr Leu Thr Met Lys Tyr Gly Gly Glu Leu Val Pro His Phe 
                1205                1210                1215    
Pro Ala Arg Val Lys Val Glu Pro Ala Val Asp Thr Ser Arg Ile Lys 
            1220                1225                1230        
Val Phe Gly Pro Gly Ile Glu Gly Lys Asp Val Phe Arg Glu Ala Thr 
        1235                1240                1245            
Thr Asp Phe Thr Val Asp Ser Arg Pro Leu Thr Gln Val Gly Gly Asp 
    1250                1255                1260                
His Ile Lys Ala His Ile Ala Asn Pro Ser Gly Ala Ser Thr Glu Cys 
1265                1270                1275                1280
Phe Val Thr Asp Asn Ala Asp Gly Thr Tyr Gln Val Glu Tyr Thr Pro 
                1285                1290                1295    
Phe Glu Lys Gly Leu His Val Val Glu Val Thr Tyr Asp Asp Val Pro 
            1300                1305                1310        
Ile Pro Asn Ser Pro Phe Lys Val Ala Val Thr Glu Gly Cys Gln Pro 
        1315                1320                1325            
Ser Arg Val Gln Ala Gln Gly Pro Gly Leu Lys Glu Ala Phe Thr Asn 
    1330                1335                1340                
Lys Pro Asn Val Phe Thr Val Val Thr Arg Gly Ala Gly Ile Gly Gly 
1345                1350                1355                1360
Leu Gly Ile Thr Val Glu Gly Pro Ser Glu Ser Lys Ile Asn Cys Arg 
                1365                1370                1375    
Asp Asn Lys Asp Gly Ser Cys Ser Ala Glu Tyr Ile Pro Phe Ala Pro 
            1380                1385                1390        
Gly Asp Tyr Asp Val Asn Ile Thr Tyr Gly Gly Ala His Ile Pro Gly 
        1395                1400                1405            
Ser Pro Phe Arg Val Pro Val Lys Asp Val Val Asp Pro Ser Lys Val 
    1410                1415                1420                
Lys Ile Ala Gly Pro Gly Leu Gly Ser Gly Val Arg Ala Arg Val Leu 
1425                1430                1435                1440
Gln Ser Phe Thr Val Asp Ser Ser Lys Ala Gly Leu Ala Pro Leu Glu 
                1445                1450                1455    
Val Arg Val Leu Gly Pro Arg Ala Asp Asp Thr Asp Ser Gln Ser Trp 
            1460                1465                1470        
Arg Ser Pro Leu Lys Ala Leu Ser Glu Phe Phe Lys Gly Asp Pro Lys 
        1475                1480                1485            
Gly Asp Phe Asn Lys Thr Gly Leu Val Glu Pro Val Asn Val Val Asp 
    1490                1495                1500                
Asn Gly Asp Gly Thr His Thr Val Thr Tyr Thr Pro Ser Gln Glu Gly 
1505                1510                1515                1520
Pro Tyr Met Val Ser Val Lys Tyr Ala Asp Glu Glu Ile Pro Arg Ser 
                1525                1530                1535    
Pro Phe Lys Val Lys Val Leu Pro Thr Tyr Asp Ala Ser Lys Val Thr 
            1540                1545                1550        
Ala Ser Gly Pro Gly Leu Ser Ser Tyr Gly Val Pro Ala Ser Leu Pro 
        1555                1560                1565            
Val Asp Phe Ala Ile Asp Ala Arg Asp Ala Gly Glu Gly Leu Leu Ala 
    1570                1575                1580                
Val Gln Ile Thr Asp Gln Glu Gly Lys Pro Lys Arg Ala Ile Val His 
1585                1590                1595                1600
Asp Asn Lys Asp Gly Thr Tyr Ala Val Thr Tyr Ile Pro Asp Lys Thr 
                1605                1610                1615    
Gly Arg Tyr Met Ile Gly Val Thr Tyr Gly Gly Asp Asp Ile Pro Leu 
            1620                1625                1630        
Ser Pro Tyr Arg Ile Arg Ala Thr Gln Thr Gly Asp Ala Ser Lys Cys 
        1635                1640                1645            
Leu Ala Thr Gly Pro Gly Ile Ala Ser Thr Val Lys Thr Gly Glu Glu 
    1650                1655                1660                
Val Gly Phe Val Val Asp Ala Lys Thr Ala Gly Lys Gly Lys Val Thr 
1665                1670                1675                1680
Cys Thr Val Leu Thr Pro Asp Gly Thr Glu Ala Glu Ala Asp Val Ile 
                1685                1690                1695    
Glu Asn Glu Asp Gly Thr Tyr Asp Ile Phe Tyr Thr Ala Ala Lys Pro 
            1700                1705                1710        
Gly Thr Tyr Val Ile Tyr Val Arg Phe Gly Gly Val Asp Ile Pro Asn 
        1715                1720                1725            
Ser Pro Phe Thr Val Met Ala Thr Asp Gly Glu Val Thr Ala Val Glu 
    1730                1735                1740                
Glu Ala Pro Val Asn Ala Cys Pro Pro Gly Phe Arg Pro Trp Val Thr 
1745                1750                1755                1760
Glu Glu Ala Tyr Val Pro Val Ser Asp Met Asn Gly Leu Gly Phe Lys 
                1765                1770                1775    
Pro Phe Asp Leu Val Ile Pro Phe Ala Val Arg Lys Gly Glu Ile Thr 
            1780                1785                1790        
Gly Glu Val His Met Pro Ser Gly Lys Thr Ala Thr Pro Glu Ile Val 
        1795                1800                1805            
Asp Asn Lys Asp Gly Thr Val Thr Val Arg Tyr Ala Pro Thr Glu Val 
    1810                1815                1820                
Gly Leu His Glu Met His Ile Lys Tyr Met Gly Ser His Ile Pro Glu 
1825                1830                1835                1840
Ser Pro Leu Gln Phe Tyr Val Asn Tyr Pro Asn Ser Gly Ser Val Ser 
                1845                1850                1855    
Ala Tyr Gly Pro Gly Leu Val Tyr Gly Val Ala Asn Lys Thr Ala Thr 
            1860                1865                1870        
Phe Thr Ile Val Thr Glu Asp Ala Gly Glu Gly Gly Leu Asp Leu Ala 
        1875                1880                1885            
Ile Glu Gly Pro Ser Lys Ala Glu Ile Ser Cys Ile Asp Asn Lys Asp 
    1890                1895                1900                
Gly Thr Cys Thr Val Thr Tyr Leu Pro Thr Leu Pro Gly Asp Tyr Ser 
1905                1910                1915                1920
Ile Leu Val Lys Tyr Asn Asp Lys His Ile Pro Gly Ser Pro Phe Thr 
                1925                1930                1935    
Ala Lys Ile Thr Asp Asp Ser Arg Arg Cys Ser Gln Val Lys Leu Gly 
            1940                1945                1950        
Ser Ala Ala Asp Phe Leu Leu Asp Ile Ser Glu Thr Asp Leu Ser Ser 
        1955                1960                1965            
Leu Thr Ala Ser Ile Lys Ala Pro Ser Gly Arg Asp Glu Pro Cys Leu 
    1970                1975                1980                
Leu Lys Arg Leu Pro Asn Asn His Ile Gly Ile Ser Phe Ile Pro Arg 
1985                1990                1995                2000
Glu Val Gly Glu His Leu Val Ser Ile Lys Lys Asn Gly Asn His Val 
                2005                2010                2015    
Ala Asn Ser Pro Val Ser Ile Met Val Val Gln Ser Glu Ile Gly Asp 
            2020                2025                2030        
Ala Arg Arg Ala Lys Val Tyr Gly Arg Gly Leu Ser Glu Gly Arg Thr 
        2035                2040                2045            
Phe Glu Met Ser Asp Phe Ile Val Asp Thr Arg Asp Ala Gly Tyr Gly 
    2050                2055                2060                
Gly Ile Ser Leu Ala Val Glu Gly Pro Ser Lys Val Asp Ile Gln Thr 
2065                2070                2075                2080
Glu Asp Leu Glu Asp Gly Thr Cys Lys Val Ser Tyr Phe Pro Thr Val 
                2085                2090                2095    
Pro Gly Val Tyr Ile Val Ser Thr Lys Phe Ala Asp Glu His Val Pro 
            2100                2105                2110        
Gly Ser Pro Phe Thr Val Lys Ile Ser Gly Glu Gly Arg Val Lys Glu 
        2115                2120                2125            
Ser Ile Thr Arg Thr Ser Arg Ala Pro Ser Val Ala Thr Val Gly Ser 
    2130                2135                2140                
Ile Cys Asp Leu Asn Leu Lys Ile Pro Glu Ile Asn Ser Ser Asp Met 
2145                2150                2155                2160
Ser Ala His Val Thr Ser Pro Ser Gly Arg Val Thr Glu Ala Glu Ile 
                2165                2170                2175    
Val Pro Met Gly Lys Asn Ser His Cys Val Arg Phe Val Pro Gln Glu 
            2180                2185                2190        
Met Gly Val His Thr Val Ser Val Lys Tyr Arg Gly Gln His Val Thr 
        2195                2200                2205            
Gly Ser Pro Phe Gln Phe Thr Val Gly Pro Leu Gly Glu Gly Gly Ala 
    2210                2215                2220                
His Lys Val Arg Ala Gly Gly Pro Gly Leu Glu Arg Gly Glu Ala Gly 
2225                2230                2235                2240
Val Pro Ala Glu Phe Ser Ile Trp Thr Arg Glu Ala Gly Ala Gly Gly 
                2245                2250                2255    
Leu Ser Ile Ala Val Glu Gly Pro Ser Lys Ala Glu Ile Thr Phe Asp 
            2260                2265                2270        
Asp His Lys Asn Gly Ser Cys Gly Val Ser Tyr Ile Ala Gln Glu Pro 
        2275                2280                2285            
Gly Asn Tyr Glu Val Ser Ile Lys Phe Asn Asp Glu His Ile Pro Glu 
    2290                2295                2300                
Ser Pro Tyr Leu Val Pro Val Ile Ala Pro Ser Asp Asp Ala Arg Arg 
2305                2310                2315                2320
Leu Thr Val Met Ser Leu Arg Glu Ser Gly Leu Lys Val Asn Gln Pro 
                2325                2330                2335    
Ala Ser Phe Ala Ile Arg Leu Asn Gly Ala Lys Gly Lys Ile Asp Ala 
            2340                2345                2350        
Lys Val His Ser Pro Ser Gly Ala Val Glu Glu Cys His Val Ser Glu 
        2355                2360                2365            
Leu Glu Pro Asp Lys Tyr Ala Val Arg Phe Ile Pro His Glu Asn Gly 
    2370                2375                2380                
Val His Thr Ile Asp Val Lys Phe Asn Gly Ser His Val Val Gly Ser 
2385                2390                2395                2400
Pro Phe Lys Val Arg Val Gly Glu Pro Gly Gln Ala Gly Asn Pro Ala 
                2405                2410                2415    
Leu Val Ser Ala Tyr Gly Thr Gly Leu Glu Gly Gly Thr Thr Gly Ile 
            2420                2425                2430        
Gln Ser Glu Phe Phe Ile Asn Thr Thr Arg Ala Gly Pro Gly Thr Leu 
        2435                2440                2445            
Ser Val Thr Ile Glu Gly Pro Ser Lys Val Lys Met Asp Cys Gln Glu 
    2450                2455                2460                
Thr Pro Glu Gly Tyr Lys Val Met Tyr Thr Pro Met Ala Pro Gly Asn 
2465                2470                2475                2480
Tyr Leu Ile Ser Val Lys Tyr Gly Gly Pro Asn His Ile Val Gly Ser 
                2485                2490                2495    
Pro Phe Lys Ala Lys Val Thr Gly Gln Arg Leu Val Ser Pro Gly Ser 
            2500                2505                2510        
Ala Asn Glu Thr Ser Ser Ile Leu Val Glu Ser Val Thr Arg Ser Ser 
        2515                2520                2525            
Thr Glu Thr Cys Tyr Ser Ala Ile Pro Lys Ala Ser Ser Asp Ala Ser 
    2530                2535                2540                
Lys Val Thr Ser Lys Gly Ala Gly Leu Ser Lys Ala Phe Val Gly Gln 
2545                2550                2555                2560
Lys Ser Ser Phe Leu Val Asp Cys Ser Lys Ala Gly Ser Asn Met Leu 
                2565                2570                2575    
Leu Ile Gly Val His Gly Pro Thr Thr Pro Cys Glu Glu Val Ser Met 
            2580                2585                2590        
Lys His Val Gly Asn Gln Gln Tyr Asn Val Thr Tyr Val Val Lys Glu 
        2595                2600                2605            
Arg Gly Asp Tyr Val Leu Ala Val Lys Trp Gly Glu Glu His Ile Pro 
    2610                2615                2620                
Gly Ser Pro Phe His Val Thr Val Pro 
2625                2630            

<210> 6
<211> 7902
<212> DNA
<213> Homo sapiens


<220> 
<223> Filamin B isoform 1 modified cDNA sequence

<400> 6
atgccggtaa ccgagaagga tctagctgag gacgcgcctt ggaagaagat ccagcagaac       60

acgttcacac gctggtgcaa cgagcacctc aagtgcgtga acaaacgcat cggcaacctg      120

cagaccgacc tgagcgacgg gctgcggctc atcgcgctgc tcgaggtgct cagccagaag      180

cgcatgtacc gcaagtacca tcagcggccc acctttcgcc agatgcagct cgagaatgtg      240

tccgtggcgc tcgagttcct ggaccgtgag agcatcaagc tcgtgtccat cgatagcaaa      300

gccattgtgg atgggaacct gaagctcatc ttgggtctgg tgtggacgct gatcctccac      360

tactccatct ccatgcccgt gtgggaggat gaaggggatg atgatgccaa gaagcagacg      420

ccaaagcaga ggctgctggg gtggattcag aacaagatcc cctacttgcc catcaccaac      480

tttaaccaga actggcaaga cggcaaagcc ctgggagccc tggtagacag ctgtgctcca      540

ggtctgtgcc cagactggga atcctgggac ccgcagaagc ctgtggataa tgcacgagaa      600

gccatgcagc aggcagatga ctggctgggt gtcccacagg tcatcactcc tgaagaaatc      660

attcacccgg atgtggacga gcactcagtt atgacttacc tgtcccagtt ccccaaagcc      720

aagctcaagc cgggggctcc tctcaaaccc aaactcaacc cgaagaaagc cagggcctat      780

ggcagaggaa tcgagcccac tggaaacatg gtgaagcagc cagccaagtt cactgtggac      840

accatcagcg ccgggcaagg agacgtgatg gtgtttgttg aggacccaga agggaacaaa      900

gaggaggcac aagtgacccc tgacagtgac aagaacaaga catactctgt ggagtatctg      960

cccaaggtca ccgggctaca caaagtcaca gtcctctttg caggacagca catctccaag     1020

agcccatttg aagtgagtgt tgacaaggcc cagggagatg ccagtaaagt cactgcaaaa     1080

ggtccagggt tggaagctgt agggaacatc gccaataagc ccacctactt tgacatctat     1140

acggcaggag ctggtgtggg tgacattggt gtggaggtgg aagatcccca ggggaagaac     1200

accgtggagt tgctcgtgga agacaaagga aaccaggtgt atcgatgtgt gtacaaaccc     1260

atgcagcctg gccctcacgt ggtcaagatc ttctttgctg gggacactat tcctaagagt     1320

cccttcgttg tgcaggttgg ggaagcctgc aatccaaatg cctgccgggc cagtggccga     1380

ggcctacaac ccaaaggcgt ccgtatccgg gagaccacag atttcaaggt tgacaccaaa     1440

gctgcaggaa gtggggagct cggtgtaacc atgaagggtc ctaagggtct ggaggagctg     1500

gtgaagcaga aagactttct ggatggggtc tacgcattcg agtattaccc cagcaccccg     1560

gggagataca gcattgccat cacatggggg ggacaccaca ttccaaagag cccctttgaa     1620

gttcaagttg gccctgaagc gggtatgcag aaagtccgtg cttggggccc tgggctccat     1680

ggtgggattg tcgggcggtc agcggacttc gtggtagaat ccattggctc tgaagtgggg     1740

tctctggggt ttgccattga aggcccctct caggcaaaga ttgagtacaa cgaccagaat     1800

gatggatcgt gtgatgtcaa atactggccc aaggagcctg gcgaatatgc tgttcacatc     1860

atgtgtgacg acgaagacat caaggacagc ccgtacatgg ccttcatcca cccagccacg     1920

ggaggctaca accctgatct ggttcgagca tacgggccag gtttggagaa atctggatgc     1980

attgtcaaca acctggccga gttcactgtg gatcctaagg atgctggaaa agctccctta     2040

aagatatttg ctcaggatgg ggaaggccaa cgcattgaca tccagatgaa gaaccggatg     2100

gacggcacat atgcatgctc atacaccccg gtgaaggcca tcaagcacac cattgctgtg     2160

gtctggggag gcgtgaacat cccgcacagc ccctacaggg tcaacatcgg gcaaggtagc     2220

catcctcaga aggtcaaagt gtttgggcca ggtgtggaga gaagtggtct gaaggcaaat     2280

gaacctacac acttcacggt ggactgtact gaggctgggg aaggtgatgt cagtgttggc     2340

attaagtgtg atgcccgggt gttaagtgaa gatgaggaag acgtggattt tgacattatt     2400

cacaatgcca atgatacgtt cacagtcaaa tatgtgcctc ctgctgctgg gcgatacact     2460

atcaaagttc tctttgcatc tcaggaaatc cccgccagcc ctttcagagt caaagttgac     2520

ccttcccacg atgccagcaa agtgaaggca gaaggcccag ggctcagcaa agcaggtgtg     2580

gaaaatggga aaccgaccca cttcactgtc tacaccaagg gggctgggaa agccccgctc     2640

aacgtgcagt tcaacagccc tcttcctggc gatgcagtga aggatttgga tatcatcgat     2700

aattatgact actctcacac ggttaaatat acacccaccc aacagggcaa catgcaggtt     2760

ctggtgactt acggtggcga tcccatccct aaaagccctt tcactgtggg tgttgctgca     2820

ccgctggatc tgagcaagat aaaactcaat gggctggaaa acagggtgga agttgggaag     2880

gatcaggagt tcaccgttga taccaggggg gcaggaggcc aggggaagct ggacgtgaca     2940

atcctcagcc cctctcggaa ggtcgtgcca tgcctagtga cacctgtgac aggccgggag     3000

aacagcacgg ccaagttcat ccctcgggag gaggggctgt atgctgtaga cgtgacctac     3060

gatggacacc ctgtgcccgg gagcccctac acagtggagg cctcgctgcc accagatccc     3120

agcaaggtga aggcccacgg tcccggcctc gaaggtggtc tcgtgggcaa gcctgccgag     3180

ttcaccatcg ataccaaagg agctggtact ggaggtctgg gcttaacggt ggaaggtccg     3240

tgcgaggcca aaatcgagtg ctccgacaat ggtgatggga cctgctccgt ctcttacctt     3300

cccacaaaac ccggggagta cttcgtcaac atcctctttg aagaagtcca catacctggg     3360

tctcccttca aagctgacat tgaaatgccc tttgacccct ctaaagtcgt ggcatcgggg     3420

ccaggtctcg agcacgggaa ggtgggtgaa gctggcctcc ttagcgtcga ctgctcggaa     3480

gcgggaccgg gggccctggg cctggaagct gtctcggact cgggaacaaa agccgaagtc     3540

agtattcaga acaacaaaga tggcacctac gcggtgacct acgtgcccct gacggccggc     3600

atgtacacgt tgaccatgaa gtatggtggc gaactcgtgc cacacttccc cgcccgggtc     3660

aaggtggagc ccgccgtgga caccagcagg atcaaagtct ttggaccagg aatagaaggg     3720

aaagatgtgt tccgggaagc taccaccgac tttacagttg actctcggcc gctgacccag     3780

gttgggggtg accacatcaa ggcccacatt gccaacccct caggggcctc caccgagtgc     3840

tttgtcacag acaatgcgga tgggacctac caggtggaat acacaccctt tgagaaaggt     3900

ctccatgtag tggaggtgac atatgatgac gtgcctatcc caaacagtcc cttcaaggtg     3960

gctgtcactg aaggctgcca gccatctagg gtgcaagccc aaggacctgg attgaaagag     4020

gcctttacca acaagcccaa tgtcttcacc gtggttacca gaggcgcagg aattggtggg     4080

cttggcataa ctgttgaggg accatcagag tcgaagataa attgcagaga caacaaggat     4140

ggcagctgca gtgctgagta cattcctttc gcaccggggg attacgatgt taatatcaca     4200

tatggaggag cccacatccc cggcagcccc ttcagggttc ctgtgaagga tgttgtggac     4260

cccagcaagg tcaagattgc cggccccggg ctgggctcag gcgtccgagc ccgtgtcctg     4320

cagtccttca cggtggacag cagcaaggct ggcctggctc cgctggaagt gagggttctg     4380

ggcccacgag ctgacgacac ggattcccag tcatggcgca gccccttgaa agccctttca     4440

gagttcttta aaggtgaccc gaagggtgac tttaataaga caggcttggt ggagccagtg     4500

aacgtggtgg acaatggaga tggcacacac acagtaacct acaccccatc tcaggaggga     4560

ccttacatgg tctcagttaa atatgctgat gaagagattc ctcgcagtcc cttcaaggtc     4620

aaggtccttc ccacatatga tgccagcaaa gtgactgcca gtggccccgg ccttagttcc     4680

tatggtgtgc ctgccagtct acctgtggac tttgcaattg atgcccgaga tgccggggaa     4740

ggcctgcttg ctgttcaaat aacggaccaa gaaggaaaac ccaaaagagc cattgtccat     4800

gacaataaag atggcacgta tgctgtcacc tacatccccg acaagactgg gcgctatatg     4860

attggagtca cctacggggg tgacgacatc ccactttctc cttatcgcat ccgagccaca     4920

cagacgggtg atgccagcaa gtgcctggcc acgggtcctg gaatcgcctc cactgtgaaa     4980

actggcgaag aagtaggctt tgtggttgat gccaagactg ccgggaaggg taaagtgacc     5040

tgcacggttc tgaccccaga tggcactgag gccgaggccg atgtcattga gaatgaagat     5100

ggaacctatg acatcttcta cacagctgcc aagccgggca catatgtgat ctatgtgcgc     5160

ttcggtggtg ttgatattcc taacagcccc ttcactgtca tggccacaga tggggaagtc     5220

acagccgtgg aggaggcacc ggtaaatgca tgtccccctg gattcaggcc ctgggtgacc     5280

gaagaggcct atgtcccagt gagtgacatg aacggcctgg gatttaagcc ttttgacctg     5340

gtcattccgt ttgctgtcag gaaaggagaa atcactggag aggtccacat gccttctggg     5400

aagacagcca cacctgagat tgtggacaac aaggacggca cggtcactgt tagatatgcc     5460

cccactgagg tcgggctcca tgagatgcac atcaaataca tgggcagcca catccctgag     5520

agcccactcc agttctacgt gaactacccc aacagtggaa gtgtttctgc atacggtcca     5580

ggcctcgtgt atggagtggc caacaaaact gccaccttca ccatcgtcac agaggatgca     5640

ggagaaggtg gtctggactt ggctattgag ggcccctcaa aagcagaaat cagctgcatt     5700

gacaataaag atgggacatg cacagtgacc tacctgccga ctctgccagg cgactacagc     5760

attctggtca agtacaatga caagcacatc cctggcagcc ccttcacagc caagatcaca     5820

gatgacagca ggcggtgctc ccaggtgaag ttgggctcag ccgctgactt cctgctcgac     5880

atcagtgaga ctgacctcag cagcctgacg gccagcatta aggccccatc tggccgagac     5940

gagccctgtc tcctgaagag gctgcccaac aaccacattg gcatctcctt catcccccgg     6000

gaagtgggcg aacatctggt cagcatcaag aaaaatggca accatgtggc caacagcccc     6060

gtgtctatca tggtggtcca gtcggagatt ggtgacgccc gccgagccaa agtctatggc     6120

cgcggcctgt cagaaggccg gactttcgag atgtctgact tcatcgtgga cacaagggat     6180

gcaggttatg gtggcatatc cttggcggtg gaaggcccca gcaaagtgga catccagacg     6240

gaggacctgg aagatggcac ctgcaaagtc tcctacttcc ctaccgtgcc tggggtttat     6300

atcgtctcca ccaaattcgc tgacgagcac gtgcctggga gcccatttac cgtgaagatc     6360

agtggggagg gaagagtcaa agagagcatc acccgcacca gtcgggcccc gtccgtggcc     6420

actgtcggga gcatttgtga cctgaacctg aaaatcccag aaatcaacag cagtgatatg     6480

tcggcccacg tcaccagccc ctctggccgt gtgactgagg cagagattgt gcccatgggg     6540

aagaactcac actgcgtccg gtttgtgccc caggagatgg gcgtgcacac ggtcagcgtc     6600

aagtaccgtg ggcagcacgt caccggcagc cccttccagt tcaccgtggg gccacttggt     6660

gaaggaggcg cccacaaggt gcgggcagga ggccctggcc tggagagagg agaagcggga     6720

gtcccagctg agttcagcat ttggacccgg gaagcaggcg ctggaggcct ctccatcgct     6780

gttgagggcc ccagtaaggc cgagattaca ttcgatgacc ataaaaatgg gtcgtgcggt     6840

gtatcttata ttgcccaaga gcctggtaac tacgaggtgt ccatcaagtt caatgatgag     6900

cacatcccgg aaagccccta cctggtgccg gtcatcgcac cctccgacga cgcccgccgc     6960

ctcactgtta tgagccttcg ggaatcggga ttaaaagtta accagccagc atcctttgct     7020

ataaggttga atggcgcaaa aggcaagatt gatgcaaagg tgcacagccc ctctggagcc     7080

gtggaggagt gccacgtgtc tgagctggag ccagataagt atgctgttcg cttcatccct     7140

catgagaatg gtgtccacac catcgatgtc aagttcaatg ggagccacgt ggttggaagc     7200

cccttcaaag tgcgcgttgg ggagcctgga caagcgggga accctgccct ggtgtccgcc     7260

tatggcacgg gactcgaagg gggcaccaca ggtatccagt cggaattctt tattaacacc     7320

acccgagcag gtccagggac attatccgtc accatcgaag gcccatccaa ggttaaaatg     7380

gattgccagg aaacacctga agggtacaaa gtcatgtaca cccccatggc tcctggtaac     7440

tacctgatca gcgtcaaata cggtgggccc aaccacatcg tgggcagtcc cttcaaggcc     7500

aaggtgacag gccagcgtct agttagccct ggctcagcca acgagacctc atccatcctg     7560

gtggagtcag tgaccaggtc gtctacagag acctgctata gcgccattcc caaggcatcc     7620

tcggacgcca gcaaggtgac ctctaagggg gcagggctct caaaggcctt tgtgggccag     7680

aagagttcct tcctggtgga ctgcagcaaa gctggctcca acatgctgct gatcggggtc     7740

catgggccca ccaccccctg cgaggaggtc tccatgaagc atgtaggcaa ccagcaatac     7800

aacgtcacat acgtcgtcaa ggagaggggc gattatgtgc tggctgtgaa gtggggggag     7860

gaacacatcc ctggcagccc ttttcatgtc acagtgcctt aa                        7902


<210> 7
<211> 8533
<212> RNA
<213> Homo sapiens


<220> 
<223> filamin A isoform 1 mRNA

<400> 7
auucgcgugg aggcgcgucg cgcgcagcgg acgccgacag aauccccgag gcgccuggcg       60

cgggcgcggg cgcgaaggcg auccgggcgc caccccgcgg ucaucgguca ccggucgcuc      120

ucaggaacag cagcgcaacc ucugcucccu gccucgccuc ccgcgcgccu aggugccugc      180

gacuuuaauu aaagggccgu ccccucgccg aggcugcagc accgcccccc cggcuucucg      240

cgccucaaaa ugaguagcuc ccacucucgg gcgggccaga gcgcagcagg cgcggcuccg      300

ggcggcggcg ucgacacgcg ggacgccgag augccggcca ccgagaagga ccuggcggag      360

gacgcgccgu ggaagaagau ccagcagaac acuuucacgc gcuggugcaa cgagcaccug      420

aagugcguga gcaagcgcau cgccaaccug cagacggacc ugagcgacgg gcugcggcuu      480

aucgcgcugu uggaggugcu cagccagaag aagaugcacc gcaagcacaa ccagcggccc      540

acuuuccgcc aaaugcagcu ugagaacgug ucgguggcgc ucgaguuccu ggaccgcgag      600

agcaucaaac ugguguccau cgacagcaag gccaucgugg acgggaaccu gaagcugauc      660

cugggccuca ucuggacccu gauccugcac uacuccaucu ccaugcccau gugggacgag      720

gaggaggaug aggaggccaa gaagcagacc cccaagcaga ggcuccuggg cuggauccag      780

aacaagcugc cgcagcugcc caucaccaac uucagccggg acuggcagag cggccgggcc      840

cugggcgccc ugguggacag cugugccccg ggccuguguc cugacuggga cucuugggac      900

gccagcaagc ccguuaccaa ugcgcgagag gccaugcagc aggcggauga cuggcugggc      960

aucccccagg ugaucacccc cgaggagauu guggacccca acguggacga gcacucuguc     1020

augaccuacc ugucccaguu ccccaaggcc aagcugaagc caggggcucc cuugcggccc     1080

aaacugaacc cgaagaaagc ccgugccuac gggccaggca ucgagcccac aggcaacaug     1140

gugaagaagc gggcagaguu cacuguggag accagaagug cuggccaggg agaggugcug     1200

guguacgugg aggacccggc cggacaccag gaggaggcaa aagugaccgc caauaacgac     1260

aagaaccgca ccuucuccgu cugguacguc cccgagguga cggggacuca uaagguuacu     1320

gugcucuuug cuggccagca caucgccaag agccccuucg agguguacgu ggauaaguca     1380

cagggugacg ccagcaaagu gacagcccaa ggucccggcc uggagcccag uggcaacauc     1440

gccaacaaga ccaccuacuu ugagaucuuu acggcaggag cuggcacggg cgaggucgag     1500

guugugaucc aggaccccau gggacagaag ggcacgguag agccucagcu ggaggcccgg     1560

ggcgacagca cauaccgcug cagcuaccag cccaccaugg agggcgucca caccgugcac     1620

gucacguuug ccggcgugcc caucccucgc agccccuaca cugucacugu uggccaagcc     1680

uguaacccga gugccugccg ggcgguuggc cggggccucc agcccaaggg ugugcgggug     1740

aaggagacag cugacuucaa gguguacaca aagggcgcug gcagugggga gcugaagguc     1800

accgugaagg gccccaaggg agaggagcgc gugaagcaga aggaccuggg ggauggcgug     1860

uauggcuucg aguauuaccc cauggucccu ggaaccuaua ucgucaccau cacguggggu     1920

ggucagaaca ucgggcgcag ucccuucgaa gugaaggugg gcaccgagug uggcaaucag     1980

aagguacggg ccuggggccc ugggcuggag ggcggcgucg uuggcaaguc agcagacuuu     2040

gugguggagg cuaucgggga cgacgugggc acgcugggcu ucucggugga agggccaucg     2100

caggcuaaga ucgaauguga cgacaagggc gacggcuccu gugaugugcg cuacuggccg     2160

caggaggcug gcgaguaugc cguucacgug cugugcaaca gcgaagacau ccgccucagc     2220

cccuucaugg cugacauccg ugacgcgccc caggacuucc acccagacag ggugaaggca     2280

cgugggccug gauuggagaa gacaggugug gccgucaaca agccagcaga guucacagug     2340

gaugccaagc acgguggcaa ggccccacuu cggguccaag uccaggacaa ugaaggcugc     2400

ccuguggagg cguuggucaa ggacaacggc aauggcacuu acagcugcuc cuacgugccc     2460

aggaagccgg ugaagcacac agccauggug uccuggggag gcgucagcau ccccaacagc     2520

cccuucaggg ugaauguggg agcuggcagc caccccaaca aggucaaagu auacggcccc     2580

ggaguagcca agacagggcu caaggcccac gagcccaccu acuucacugu ggacugcgcc     2640

gaggcuggcc agggggacgu cagcaucggc aucaagugug ccccuggagu gguaggcccc     2700

gccgaagcug acaucgacuu cgacaucauc cgcaaugaca augacaccuu cacggucaag     2760

uacacgcccc ggggggcugg cagcuacacc auuauggucc ucuuugcuga ccaggccacg     2820

cccaccagcc ccauccgagu caagguggag cccucucaug acgccaguaa ggugaaggcc     2880

gagggcccug gccucagucg cacugguguc gagcuuggca agcccaccca cuucacagua     2940

aaugccaaag cugcuggcaa aggcaagcug gacguccagu ucucaggacu caccaagggg     3000

gaugcagugc gagaugugga caucaucgac caccaugaca acaccuacac agucaaguac     3060

acgccugucc agcagggucc aguaggcguc aaugucacuu auggagggga ucccaucccu     3120

aagagcccuu ucucaguggc aguaucucca agccuggacc ucagcaagau caaggugucu     3180

ggccugggag agaaggugga cguuggcaaa gaccaggagu ucacagucaa aucaaagggu     3240

gcuggugguc aaggcaaagu ggcauccaag auugugggcc ccucgggugc agcggugccc     3300

ugcaaggugg agccaggccu gggggcugac aacagugugg ugcgcuuccu gccccgugag     3360

gaagggcccu augaggugga ggugaccuau gacggcgugc ccgugccugg cagccccuuu     3420

ccucuggaag cuguggcccc caccaagccu agcaagguga aggcguuugg gccggggcug     3480

cagggaggca gugcgggcuc ccccgcccgc uucaccaucg acaccaaggg cgccggcaca     3540

gguggccugg gccugacggu ggagggcccc ugugaggcgc agcucgagug cuuggacaau     3600

ggggauggca cauguuccgu guccuacgug cccaccgagc ccggggacua caacaucaac     3660

auccucuucg cugacaccca caucccuggc uccccauuca aggcccacgu gguucccugc     3720

uuugacgcau ccaaagucaa gugcucaggc cccgggcugg agcgggccac cgcuggggag     3780

gugggccaau uccaagugga cugcucgagc gcgggcagcg cggagcugac cauugagauc     3840

ugcucggagg cggggcuucc ggccgaggug uacauccagg accacgguga uggcacgcac     3900

accauuaccu acauuccccu cugccccggg gccuacaccg ucaccaucaa guacggcggc     3960

cagcccgugc ccaacuuccc cagcaagcug cagguggaac cugcggugga cacuuccggu     4020

guccagugcu augggccugg uauugagggc cagggugucu uccgugaggc caccacugag     4080

uucagugugg acgcccgggc ucugacacag accggagggc cgcacgucaa ggcccgugug     4140

gccaaccccu caggcaaccu gacggagacc uacguucagg accguggcga uggcauguac     4200

aaaguggagu acacgccuua cgaggaggga cugcacuccg uggacgugac cuaugacggc     4260

agucccgugc ccagcagccc cuuccaggug cccgugaccg agggcugcga ccccucccgg     4320

gugcgugucc acgggccagg cauccaaagu ggcaccacca acaagcccaa caaguucacu     4380

guggagacca ggggagcugg cacgggcggc cugggccugg cuguagaggg ccccuccgag     4440

gccaagaugu ccugcaugga uaacaaggac ggcagcugcu cggucgagua caucccuuau     4500

gaggcuggca ccuacagccu caacgucacc uaugguggcc aucaagugcc aggcaguccu     4560

uucaaggucc cugugcauga ugugacagau gcguccaagg ucaagugcuc ugggcccggc     4620

cugagcccag gcaugguucg ugccaaccuc ccucaguccu uccaggugga cacaagcaag     4680

gcuggugugg ccccauugca ggucaaagug caagggccca aaggccuggu ggagccagug     4740

gacgugguag acaacgcuga uggcacccag accgucaauu augugcccag ccgagaaggg     4800

cccuacagca ucucaguacu guauggagau gaagagguac cccggagccc cuucaagguc     4860

aaggugcugc cuacucauga ugccagcaag gugaaggcca guggccccgg gcucaacacc     4920

acuggcgugc cugccagccu gcccguggag uucaccaucg augcaaagga cgccggggag     4980

ggccugcugg cuguccagau cacggauccc gaaggcaagc cgaagaagac acacauccaa     5040

gacaaccaug acggcacgua uacaguggcc uacgugccag acgugacagg ucgcuacacc     5100

auccucauca aguacggugg ugacgagauc cccuucuccc cguaccgcgu gcgugccgug     5160

cccaccgggg acgccagcaa gugcacuguc acaggugcug gcaucggccc caccauucag     5220

auuggggagg agacggugau cacuguggac acuaaggcgg caggcaaagg caaagugacg     5280

ugcaccgugu gcacgccuga uggcucagag guggaugugg acguggugga gaaugaggac     5340

ggcacuuucg acaucuucua cacggccccc cagccgggca aauacgucau cugugugcgc     5400

uuugguggcg agcacgugcc caacagcccc uuccaaguga cggcucuggc uggggaccag     5460

cccucggugc agcccccucu acggucucag cagcuggccc cacaguacac cuacgcccag     5520

ggcggccagc agacuugggc cccggagagg ccccuggugg gugucaaugg gcuggaugug     5580

accagccuga ggcccuuuga ccuugucauc cccuucacca ucaagaaggg cgagaucaca     5640

ggggagguuc ggaugcccuc aggcaaggug gcgcagccca ccaucacuga caacaaagac     5700

ggcaccguga ccgugcggua ugcacccagc gaggcuggcc ugcacgagau ggacauccgc     5760

uaugacaaca ugcacauccc aggaagcccc uugcaguucu auguggauua cgucaacugu     5820

ggccauguca cugccuaugg gccuggccuc acccauggag uagugaacaa gccugccacc     5880

uucaccguca acaccaagga ugcaggagag gggggccugu cucuggccau ugagggcccg     5940

uccaaagcag aaaucagcug cacugacaac caggauggga caugcagcgu guccuaccug     6000

ccugugcugc cgggggacua cagcauucua gucaaguaca augaacagca cgucccaggc     6060

agccccuuca cugcucgggu cacaggugac gacuccaugc guauguccca ccuaaagguc     6120

ggcucugcug ccgacauccc caucaacauc ucagagacgg aucucagccu gcugacggcc     6180

acuguggucc cgcccucggg ccgggaggag cccuguuugc ugaagcggcu gcguaauggc     6240

cacgugggga uuucauucgu gcccaaggag acgggggagc accuggugca ugugaagaaa     6300

aauggccagc acguggccag cagccccauc ccggugguga ucagccaguc ggaaauuggg     6360

gaugccaguc guguucgggu cucuggucag ggccuucacg aaggccacac cuuugagccu     6420

gcagaguuua ucauugauac ccgcgaugca ggcuauggug ggcucagccu guccauugag     6480

ggccccagca agguggacau caacacagag gaccuggagg acgggacgug cagggucacc     6540

uacugcccca cagagccagg caacuacauc aucaacauca aguuugccga ccagcacgug     6600

ccuggcagcc ccuucucugu gaaggugaca ggcgagggcc gggugaaaga gagcaucacc     6660

cgcaggcguc gggcuccuuc aguggccaac guugguaguc auugugaccu cagccugaaa     6720

aucccugaaa uuagcaucca ggauaugaca gcccagguga ccagcccauc gggcaagacc     6780

caugaggccg agaucgugga aggggagaac cacaccuacu gcauccgcuu uguucccgcu     6840

gagaugggca cacacacagu cagcgugaag uacaagggcc agcacgugcc ugggagcccc     6900

uuccaguuca ccguggggcc ccuaggggaa gggggagccc acaagguccg agcugggggc     6960

ccuggccugg agagagcuga agcuggagug ccagccgaau ucaguaucug gacccgggaa     7020

gcuggugcug gaggccuggc cauugcuguc gagggcccca gcaaggcuga gaucucuuuu     7080

gaggaccgca aggacggcuc cuguggugug gcuuaugugg uccaggagcc aggugacuac     7140

gaagucucag ucaaguucaa cgaggaacac auucccgaca gccccuucgu ggugccugug     7200

gcuucuccgu cuggcgacgc ccgccgccuc acuguuucua gccuucagga gucagggcua     7260

aaggucaacc agccagccuc uuuugcaguc agccugaacg gggccaaggg ggcgaucgau     7320

gccaaggugc acagccccuc aggagcccug gaggagugcu augucacaga aauugaccaa     7380

gauaaguaug cugugcgcuu caucccucgg gagaauggcg uuuaccugau ugacgucaag     7440

uucaacggca cccacauccc uggaagcccc uucaagaucc gaguugggga gccugggcau     7500

ggaggggacc caggcuuggu gucugcuuac ggagcagguc uggaaggcgg ugucacaggg     7560

aacccagcug aguucgucgu gaacacgagc aaugcgggag cuggugcccu gucggugacc     7620

auugacggcc ccuccaaggu gaagauggau ugccaggagu gcccugaggg cuaccgcguc     7680

accuauaccc ccauggcacc uggcagcuac cucaucucca ucaaguacgg cggccccuac     7740

cacauugggg gcagccccuu caaggccaaa gucacaggcc cccgucucgu cagcaaccac     7800

agccuccacg agacaucauc aguguuugua gacucucuga ccaaggccac cugugccccc     7860

cagcaugggg ccccgggucc ugggccugcu gacgccagca aggugguggc caagggccug     7920

gggcugagca aggccuacgu aggccagaag agcagcuuca caguagacug cagcaaagca     7980

ggcaacaaca ugcugcuggu ggggguucau ggcccaagga cccccugcga ggagauccug     8040

gugaagcacg ugggcagccg gcucuacagc guguccuacc ugcucaagga caagggggag     8100

uacacacugg uggucaaaug gggggacgag cacaucccag gcagccccua ccgcguugug     8160

gugcccugag ucuggggccc gugccagccg gcagccccca agccugcccc gcuacccaag     8220

cagccccgcc cucuuccccu caaccccggc ccaggccgcc cuggccgccc gccugucacu     8280

gcagccgccc cugcccugug ccgugcugcg cucaccugcc uccccagcca gccgcugacc     8340

ucucggcuuu cacuugggca gagggagcca uuugguggcg cugcuugucu ucuuugguuc     8400

ugggaggggu gagggauggg gguccuguac acaaccaccc acuaguucuc uucuccagcc     8460

aagaggaaua aaguuuugcu uccauuaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     8520

aaaaaaaaaa aaa                                                        8533


<210> 8
<211> 8557
<212> RNA
<213> Homo sapiens


<220> 
<223> filamin A isoform 2 mRNA

<400> 8
auucgcgugg aggcgcgucg cgcgcagcgg acgccgacag aauccccgag gcgccuggcg       60

cgggcgcggg cgcgaaggcg auccgggcgc caccccgcgg ucaucgguca ccggucgcuc      120

ucaggaacag cagcgcaacc ucugcucccu gccucgccuc ccgcgcgccu aggugccugc      180

gacuuuaauu aaagggccgu ccccucgccg aggcugcagc accgcccccc cggcuucucg      240

cgccucaaaa ugaguagcuc ccacucucgg gcgggccaga gcgcagcagg cgcggcuccg      300

ggcggcggcg ucgacacgcg ggacgccgag augccggcca ccgagaagga ccuggcggag      360

gacgcgccgu ggaagaagau ccagcagaac acuuucacgc gcuggugcaa cgagcaccug      420

aagugcguga gcaagcgcau cgccaaccug cagacggacc ugagcgacgg gcugcggcuu      480

aucgcgcugu uggaggugcu cagccagaag aagaugcacc gcaagcacaa ccagcggccc      540

acuuuccgcc aaaugcagcu ugagaacgug ucgguggcgc ucgaguuccu ggaccgcgag      600

agcaucaaac ugguguccau cgacagcaag gccaucgugg acgggaaccu gaagcugauc      660

cugggccuca ucuggacccu gauccugcac uacuccaucu ccaugcccau gugggacgag      720

gaggaggaug aggaggccaa gaagcagacc cccaagcaga ggcuccuggg cuggauccag      780

aacaagcugc cgcagcugcc caucaccaac uucagccggg acuggcagag cggccgggcc      840

cugggcgccc ugguggacag cugugccccg ggccuguguc cugacuggga cucuugggac      900

gccagcaagc ccguuaccaa ugcgcgagag gccaugcagc aggcggauga cuggcugggc      960

aucccccagg ugaucacccc cgaggagauu guggacccca acguggacga gcacucuguc     1020

augaccuacc ugucccaguu ccccaaggcc aagcugaagc caggggcucc cuugcggccc     1080

aaacugaacc cgaagaaagc ccgugccuac gggccaggca ucgagcccac aggcaacaug     1140

gugaagaagc gggcagaguu cacuguggag accagaagug cuggccaggg agaggugcug     1200

guguacgugg aggacccggc cggacaccag gaggaggcaa aagugaccgc caauaacgac     1260

aagaaccgca ccuucuccgu cugguacguc cccgagguga cggggacuca uaagguuacu     1320

gugcucuuug cuggccagca caucgccaag agccccuucg agguguacgu ggauaaguca     1380

cagggugacg ccagcaaagu gacagcccaa ggucccggcc uggagcccag uggcaacauc     1440

gccaacaaga ccaccuacuu ugagaucuuu acggcaggag cuggcacggg cgaggucgag     1500

guugugaucc aggaccccau gggacagaag ggcacgguag agccucagcu ggaggcccgg     1560

ggcgacagca cauaccgcug cagcuaccag cccaccaugg agggcgucca caccgugcac     1620

gucacguuug ccggcgugcc caucccucgc agccccuaca cugucacugu uggccaagcc     1680

uguaacccga gugccugccg ggcgguuggc cggggccucc agcccaaggg ugugcgggug     1740

aaggagacag cugacuucaa gguguacaca aagggcgcug gcagugggga gcugaagguc     1800

accgugaagg gccccaaggg agaggagcgc gugaagcaga aggaccuggg ggauggcgug     1860

uauggcuucg aguauuaccc cauggucccu ggaaccuaua ucgucaccau cacguggggu     1920

ggucagaaca ucgggcgcag ucccuucgaa gugaaggugg gcaccgagug uggcaaucag     1980

aagguacggg ccuggggccc ugggcuggag ggcggcgucg uuggcaaguc agcagacuuu     2040

gugguggagg cuaucgggga cgacgugggc acgcugggcu ucucggugga agggccaucg     2100

caggcuaaga ucgaauguga cgacaagggc gacggcuccu gugaugugcg cuacuggccg     2160

caggaggcug gcgaguaugc cguucacgug cugugcaaca gcgaagacau ccgccucagc     2220

cccuucaugg cugacauccg ugacgcgccc caggacuucc acccagacag ggugaaggca     2280

cgugggccug gauuggagaa gacaggugug gccgucaaca agccagcaga guucacagug     2340

gaugccaagc acgguggcaa ggccccacuu cggguccaag uccaggacaa ugaaggcugc     2400

ccuguggagg cguuggucaa ggacaacggc aauggcacuu acagcugcuc cuacgugccc     2460

aggaagccgg ugaagcacac agccauggug uccuggggag gcgucagcau ccccaacagc     2520

cccuucaggg ugaauguggg agcuggcagc caccccaaca aggucaaagu auacggcccc     2580

ggaguagcca agacagggcu caaggcccac gagcccaccu acuucacugu ggacugcgcc     2640

gaggcuggcc agggggacgu cagcaucggc aucaagugug ccccuggagu gguaggcccc     2700

gccgaagcug acaucgacuu cgacaucauc cgcaaugaca augacaccuu cacggucaag     2760

uacacgcccc ggggggcugg cagcuacacc auuauggucc ucuuugcuga ccaggccacg     2820

cccaccagcc ccauccgagu caagguggag cccucucaug acgccaguaa ggugaaggcc     2880

gagggcccug gccucagucg cacugguguc gagcuuggca agcccaccca cuucacagua     2940

aaugccaaag cugcuggcaa aggcaagcug gacguccagu ucucaggacu caccaagggg     3000

gaugcagugc gagaugugga caucaucgac caccaugaca acaccuacac agucaaguac     3060

acgccugucc agcagggucc aguaggcguc aaugucacuu auggagggga ucccaucccu     3120

aagagcccuu ucucaguggc aguaucucca agccuggacc ucagcaagau caaggugucu     3180

ggccugggag agaaggugga cguuggcaaa gaccaggagu ucacagucaa aucaaagggu     3240

gcuggugguc aaggcaaagu ggcauccaag auugugggcc ccucgggugc agcggugccc     3300

ugcaaggugg agccaggccu gggggcugac aacagugugg ugcgcuuccu gccccgugag     3360

gaagggcccu augaggugga ggugaccuau gacggcgugc ccgugccugg cagccccuuu     3420

ccucuggaag cuguggcccc caccaagccu agcaagguga aggcguuugg gccggggcug     3480

cagggaggca gugcgggcuc ccccgcccgc uucaccaucg acaccaaggg cgccggcaca     3540

gguggccugg gccugacggu ggagggcccc ugugaggcgc agcucgagug cuuggacaau     3600

ggggauggca cauguuccgu guccuacgug cccaccgagc ccggggacua caacaucaac     3660

auccucuucg cugacaccca caucccuggc uccccauuca aggcccacgu gguucccugc     3720

uuugacgcau ccaaagucaa gugcucaggc cccgggcugg agcgggccac cgcuggggag     3780

gugggccaau uccaagugga cugcucgagc gcgggcagcg cggagcugac cauugagauc     3840

ugcucggagg cggggcuucc ggccgaggug uacauccagg accacgguga uggcacgcac     3900

accauuaccu acauuccccu cugccccggg gccuacaccg ucaccaucaa guacggcggc     3960

cagcccgugc ccaacuuccc cagcaagcug cagguggaac cugcggugga cacuuccggu     4020

guccagugcu augggccugg uauugagggc cagggugucu uccgugaggc caccacugag     4080

uucagugugg acgcccgggc ucugacacag accggagggc cgcacgucaa ggcccgugug     4140

gccaaccccu caggcaaccu gacggagacc uacguucagg accguggcga uggcauguac     4200

aaaguggagu acacgccuua cgaggaggga cugcacuccg uggacgugac cuaugacggc     4260

agucccgugc ccagcagccc cuuccaggug cccgugaccg agggcugcga ccccucccgg     4320

gugcgugucc acgggccagg cauccaaagu ggcaccacca acaagcccaa caaguucacu     4380

guggagacca ggggagcugg cacgggcggc cugggccugg cuguagaggg ccccuccgag     4440

gccaagaugu ccugcaugga uaacaaggac ggcagcugcu cggucgagua caucccuuau     4500

gaggcuggca ccuacagccu caacgucacc uaugguggcc aucaagugcc aggcaguccu     4560

uucaaggucc cugugcauga ugugacagau gcguccaagg ucaagugcuc ugggcccggc     4620

cugagcccag gcaugguucg ugccaaccuc ccucaguccu uccaggugga cacaagcaag     4680

gcuggugugg ccccauugca ggucaaagug caagggccca aaggccuggu ggagccagug     4740

gacgugguag acaacgcuga uggcacccag accgucaauu augugcccag ccgagaaggg     4800

cccuacagca ucucaguacu guauggagau gaagagguac cccggagccc cuucaagguc     4860

aaggugcugc cuacucauga ugccagcaag gugaaggcca guggccccgg gcucaacacc     4920

acuggcgugc cugccagccu gcccguggag uucaccaucg augcaaagga cgccggggag     4980

ggccugcugg cuguccagau cacggauccc gaaggcaagc cgaagaagac acacauccaa     5040

gacaaccaug acggcacgua uacaguggcc uacgugccag acgugacagg ucgcuacacc     5100

auccucauca aguacggugg ugacgagauc cccuucuccc cguaccgcgu gcgugccgug     5160

cccaccgggg acgccagcaa gugcacuguc acagugucaa ucggagguca cgggcuaggu     5220

gcuggcaucg gccccaccau ucagauuggg gaggagacgg ugaucacugu ggacacuaag     5280

gcggcaggca aaggcaaagu gacgugcacc gugugcacgc cugauggcuc agagguggau     5340

guggacgugg uggagaauga ggacggcacu uucgacaucu ucuacacggc cccccagccg     5400

ggcaaauacg ucaucugugu gcgcuuuggu ggcgagcacg ugcccaacag ccccuuccaa     5460

gugacggcuc uggcugggga ccagcccucg gugcagcccc cucuacgguc ucagcagcug     5520

gccccacagu acaccuacgc ccagggcggc cagcagacuu gggccccgga gaggccccug     5580

guggguguca augggcugga ugugaccagc cugaggcccu uugaccuugu cauccccuuc     5640

accaucaaga agggcgagau cacaggggag guucggaugc ccucaggcaa gguggcgcag     5700

cccaccauca cugacaacaa agacggcacc gugaccgugc gguaugcacc cagcgaggcu     5760

ggccugcacg agauggacau ccgcuaugac aacaugcaca ucccaggaag ccccuugcag     5820

uucuaugugg auuacgucaa cuguggccau gucacugccu augggccugg ccucacccau     5880

ggaguaguga acaagccugc caccuucacc gucaacacca aggaugcagg agaggggggc     5940

cugucucugg ccauugaggg cccguccaaa gcagaaauca gcugcacuga caaccaggau     6000

gggacaugca gcguguccua ccugccugug cugccggggg acuacagcau ucuagucaag     6060

uacaaugaac agcacguccc aggcagcccc uucacugcuc gggucacagg ugacgacucc     6120

augcguaugu cccaccuaaa ggucggcucu gcugccgaca uccccaucaa caucucagag     6180

acggaucuca gccugcugac ggccacugug gucccgcccu cgggccggga ggagcccugu     6240

uugcugaagc ggcugcguaa uggccacgug gggauuucau ucgugcccaa ggagacgggg     6300

gagcaccugg ugcaugugaa gaaaaauggc cagcacgugg ccagcagccc caucccggug     6360

gugaucagcc agucggaaau uggggaugcc agucguguuc gggucucugg ucagggccuu     6420

cacgaaggcc acaccuuuga gccugcagag uuuaucauug auacccgcga ugcaggcuau     6480

ggugggcuca gccuguccau ugagggcccc agcaaggugg acaucaacac agaggaccug     6540

gaggacggga cgugcagggu caccuacugc cccacagagc caggcaacua caucaucaac     6600

aucaaguuug ccgaccagca cgugccuggc agccccuucu cugugaaggu gacaggcgag     6660

ggccggguga aagagagcau cacccgcagg cgucgggcuc cuucaguggc caacguuggu     6720

agucauugug accucagccu gaaaaucccu gaaauuagca uccaggauau gacagcccag     6780

gugaccagcc caucgggcaa gacccaugag gccgagaucg uggaagggga gaaccacacc     6840

uacugcaucc gcuuuguucc cgcugagaug ggcacacaca cagucagcgu gaaguacaag     6900

ggccagcacg ugccugggag ccccuuccag uucaccgugg ggccccuagg ggaaggggga     6960

gcccacaagg uccgagcugg gggcccuggc cuggagagag cugaagcugg agugccagcc     7020

gaauucagua ucuggacccg ggaagcuggu gcuggaggcc uggccauugc ugucgagggc     7080

cccagcaagg cugagaucuc uuuugaggac cgcaaggacg gcuccugugg uguggcuuau     7140

gugguccagg agccagguga cuacgaaguc ucagucaagu ucaacgagga acacauuccc     7200

gacagccccu ucguggugcc uguggcuucu ccgucuggcg acgcccgccg ccucacuguu     7260

ucuagccuuc aggagucagg gcuaaagguc aaccagccag ccucuuuugc agucagccug     7320

aacggggcca agggggcgau cgaugccaag gugcacagcc ccucaggagc ccuggaggag     7380

ugcuauguca cagaaauuga ccaagauaag uaugcugugc gcuucauccc ucgggagaau     7440

ggcguuuacc ugauugacgu caaguucaac ggcacccaca ucccuggaag ccccuucaag     7500

auccgaguug gggagccugg gcauggaggg gacccaggcu uggugucugc uuacggagca     7560

ggucuggaag gcggugucac agggaaccca gcugaguucg ucgugaacac gagcaaugcg     7620

ggagcuggug cccugucggu gaccauugac ggccccucca aggugaagau ggauugccag     7680

gagugcccug agggcuaccg cgucaccuau acccccaugg caccuggcag cuaccucauc     7740

uccaucaagu acggcggccc cuaccacauu gggggcagcc ccuucaaggc caaagucaca     7800

ggcccccguc ucgucagcaa ccacagccuc cacgagacau caucaguguu uguagacucu     7860

cugaccaagg ccaccugugc cccccagcau ggggccccgg guccugggcc ugcugacgcc     7920

agcaaggugg uggccaaggg ccuggggcug agcaaggccu acguaggcca gaagagcagc     7980

uucacaguag acugcagcaa agcaggcaac aacaugcugc uggugggggu ucauggccca     8040

aggacccccu gcgaggagau ccuggugaag cacgugggca gccggcucua cagcgugucc     8100

uaccugcuca aggacaaggg ggaguacaca cuggugguca aaugggggga cgagcacauc     8160

ccaggcagcc ccuaccgcgu uguggugccc ugagucuggg gcccgugcca gccggcagcc     8220

cccaagccug ccccgcuacc caagcagccc cgcccucuuc cccucaaccc cggcccaggc     8280

cgcccuggcc gcccgccugu cacugcagcc gccccugccc ugugccgugc ugcgcucacc     8340

ugccucccca gccagccgcu gaccucucgg cuuucacuug ggcagaggga gccauuuggu     8400

ggcgcugcuu gucuucuuug guucugggag gggugaggga uggggguccu guacacaacc     8460

acccacuagu ucucuucucc agccaagagg aauaaaguuu ugcuuccauu aaaaaaaaaa     8520

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                              8557


<210> 9
<211> 9534
<212> RNA
<213> Homo sapiens


<220> 
<223> filamin B mRNA

<400> 9
agagcagcac cggccguggc uccgguagca gcaaguucga accccgcucc cgcuccgcuu       60

cgguucucgc uccuucggcc cuugggccuc caaacaccag uccccggcag cucguugcgc      120

auugcgcucu ccccgccacc aggaugccgg uaaccgagaa ggaucuagcu gaggacgcgc      180

cuuggaagaa gauccagcag aacacguuca cacgcuggug caacgagcac cucaagugcg      240

ugaacaaacg caucggcaac cugcagaccg accugagcga cgggcugcgg cucaucgcgc      300

ugcucgaggu gcucagccag aagcgcaugu accgcaagua ccaucagcgg cccaccuuuc      360

gccagaugca gcucgagaau guguccgugg cgcucgaguu ccuggaccgu gagagcauca      420

agcucguguc caucgauagc aaagccauug uggaugggaa ccugaagcuc aucuuggguc      480

ugguguggac gcugauccuc cacuacucca ucuccaugcc cgugugggag gaugaagggg      540

augaugaugc caagaagcag acgccaaagc agaggcugcu gggguggauu cagaacaaga      600

uccccuacuu gcccaucacc aacuuuaacc agaacuggca agacggcaaa gcccugggag      660

cccugguaga cagcugugcu ccaggucugu gcccagacug ggaauccugg gacccgcaga      720

agccugugga uaaugcacga gaagccaugc agcaggcaga ugacuggcug ggugucccac      780

aggucaucac uccugaagaa aucauucacc cggaugugga cgagcacuca guuaugacuu      840

accuguccca guuccccaaa gccaagcuca agccgggggc uccucucaaa cccaaacuca      900

acccgaagaa agccagggcc uauggcagag gaaucgagcc cacuggaaac auggugaagc      960

agccagccaa guucacugug gacaccauca gcgccgggca aggagacgug augguguuug     1020

uugaggaccc agaagggaac aaagaggagg cacaagugac cccugacagu gacaagaaca     1080

agacauacuc uguggaguau cugcccaagg ucaccgggcu acacaaaguc acaguccucu     1140

uugcaggaca gcacaucucc aagagcccau uugaagugag uguugacaag gcccagggag     1200

augccaguaa agucacugca aaagguccag gguuggaagc uguagggaac aucgccaaua     1260

agcccaccua cuuugacauc uauacggcag gagcuggugu gggugacauu gguguggagg     1320

uggaagaucc ccaggggaag aacaccgugg aguugcucgu ggaagacaaa ggaaaccagg     1380

uguaucgaug uguguacaaa cccaugcagc cuggcccuca cguggucaag aucuucuuug     1440

cuggggacac uauuccuaag agucccuucg uugugcaggu uggggaagcc ugcaauccaa     1500

augccugccg ggccaguggc cgaggccuac aacccaaagg cguccguauc cgggagacca     1560

cagauuucaa gguugacacc aaagcugcag gaagugggga gcucggugua accaugaagg     1620

guccuaaggg ucuggaggag cuggugaagc agaaagacuu ucuggauggg gucuacgcau     1680

ucgaguauua ccccagcacc ccggggagau acagcauugc caucacaugg gggggacacc     1740

acauuccaaa gagccccuuu gaaguucaag uuggcccuga agcggguaug cagaaagucc     1800

gugcuugggg cccugggcuc caugguggga uugucgggcg gucagcggac uucgugguag     1860

aauccauugg cucugaagug gggucucugg gguuugccau ugaaggcccc ucucaggcaa     1920

agauugagua caacgaccag aaugauggau cgugugaugu caaauacugg cccaaggagc     1980

cuggcgaaua ugcuguucac aucaugugug acgacgaaga caucaaggac agcccguaca     2040

uggccuucau ccacccagcc acgggaggcu acaacccuga ucugguucga gcauacgggc     2100

cagguuugga gaaaucugga ugcauuguca acaaccuggc cgaguucacu guggauccua     2160

aggaugcugg aaaagcuccc uuaaagauau uugcucagga uggggaaggc caacgcauug     2220

acauccagau gaagaaccgg auggacggca cauaugcaug cucauacacc ccggugaagg     2280

ccaucaagca caccauugcu guggucuggg gaggcgugaa caucccgcac agccccuaca     2340

gggucaacau cgggcaaggu agccauccuc agaaggucaa aguguuuggg ccaggugugg     2400

agagaagugg ucugaaggca aaugaaccua cacacuucac gguggacugu acugaggcug     2460

gggaagguga ugucaguguu ggcauuaagu gugaugcccg gguguuaagu gaagaugagg     2520

aagacgugga uuuugacauu auucacaaug ccaaugauac guucacaguc aaauaugugc     2580

cuccugcugc ugggcgauac acuaucaaag uucucuuugc aucucaggaa auccccgcca     2640

gcccuuucag agucaaaguu gacccuuccc acgaugccag caaagugaag gcagaaggcc     2700

cagggcucag caaagcaggu guggaaaaug ggaaaccgac ccacuucacu gucuacacca     2760

agggggcugg gaaagccccg cucaacgugc aguucaacag cccucuuccu ggcgaugcag     2820

ugaaggauuu ggauaucauc gauaauuaug acuacucuca cacgguuaaa uauacaccca     2880

cccaacaggg caacaugcag guucugguga cuuacggugg cgaucccauc ccuaaaagcc     2940

cuuucacugu ggguguugcu gcaccgcugg aucugagcaa gauaaaacuc aaugggcugg     3000

aaaacagggu ggaaguuggg aaggaucagg aguucaccgu ugauaccagg ggggcaggag     3060

gccaggggaa gcuggacgug acaauccuca gccccucucg gaaggucgug ccaugccuag     3120

ugacaccugu gacaggccgg gagaacagca cggccaaguu caucccucgg gaggaggggc     3180

uguaugcugu agacgugacc uacgauggac acccugugcc cgggagcccc uacacagugg     3240

aggccucgcu gccaccagau cccagcaagg ugaaggccca cggucccggc cucgaaggug     3300

gucucguggg caagccugcc gaguucacca ucgauaccaa aggagcuggu acuggagguc     3360

ugggcuuaac gguggaaggu ccgugcgagg ccaaaaucga gugcuccgac aauggugaug     3420

ggaccugcuc cgucucuuac cuucccacaa aacccgggga guacuucguc aacauccucu     3480

uugaagaagu ccacauaccu gggucucccu ucaaagcuga cauugaaaug cccuuugacc     3540

ccucuaaagu cguggcaucg gggccagguc ucgagcacgg gaaggugggu gaagcuggcc     3600

uccuuagcgu cgacugcucg gaagcgggac cgggggcccu gggccuggaa gcugucucgg     3660

acucgggaac aaaagccgaa gucaguauuc agaacaacaa agauggcacc uacgcgguga     3720

ccuacgugcc ccugacggcc ggcauguaca cguugaccau gaaguauggu ggcgaacucg     3780

ugccacacuu ccccgcccgg gucaaggugg agcccgccgu ggacaccagc aggaucaaag     3840

ucuuuggacc aggaauagaa gggaaagaug uguuccggga agcuaccacc gacuuuacag     3900

uugacucucg gccgcugacc cagguugggg gugaccacau caaggcccac auugccaacc     3960

ccucaggggc cuccaccgag ugcuuuguca cagacaaugc ggaugggacc uaccaggugg     4020

aauacacacc cuuugagaaa ggucuccaug uaguggaggu gacauaugau gacgugccua     4080

ucccaaacag ucccuucaag guggcuguca cugaaggcug ccagccaucu agggugcaag     4140

cccaaggacc uggauugaaa gaggccuuua ccaacaagcc caaugucuuc accgugguua     4200

ccagaggcgc aggaauuggu gggcuuggca uaacuguuga gggaccauca gagucgaaga     4260

uaaauugcag agacaacaag gauggcagcu gcagugcuga guacauuccu uucgcaccgg     4320

gggauuacga uguuaauauc acauauggag gagcccacau ccccggcagc cccuucaggg     4380

uuccugugaa ggauguugug gaccccagca aggucaagau ugccggcccc gggcugggcu     4440

caggcguccg agcccguguc cugcaguccu ucacggugga cagcagcaag gcuggccugg     4500

cuccgcugga agugaggguu cugggcccac gagcugacga cacggauucc cagucauggc     4560

gcagccccuu gaaagcccuu ucagaguucu uuaaagguga cccgaagggu gacuuuaaua     4620

agacaggcuu gguggagcca gugaacgugg uggacaaugg agauggcaca cacacaguaa     4680

ccuacacccc aucucaggag ggaccuuaca uggucucagu uaaauaugcu gaugaagaga     4740

uuccucgcag ucccuucaag gucaaggucc uucccacaua ugaugccagc aaagugacug     4800

ccaguggccc cggccuuagu uccuauggug ugccugccag ucuaccugug gacuuugcaa     4860

uugaugcccg agaugccggg gaaggccugc uugcuguuca aauaacggac caagaaggaa     4920

aacccaaaag agccauuguc caugacaaua aagauggcac guaugcuguc accuacaucc     4980

ccgacaagac ugggcgcuau augauuggag ucaccuacgg gggugacgac aucccacuuu     5040

cuccuuaucg cauccgagcc acacagacgg gugaugccag caagugccug gccacggguc     5100

cuggaaucgc cuccacugug aaaacuggcg aagaaguagg cuuugugguu gaugccaaga     5160

cugccgggaa ggguaaagug accugcacgg uucugacccc agauggcacu gaggccgagg     5220

ccgaugucau ugagaaugaa gauggaaccu augacaucuu cuacacagcu gccaagccgg     5280

gcacauaugu gaucuaugug cgcuucggug guguugauau uccuaacagc cccuucacug     5340

ucauggccac agauggggaa gucacagccg uggaggaggc accgguaaau gcaugucccc     5400

cuggauucag gcccugggug accgaagagg ccuauguccc agugagugac augaacggcc     5460

ugggauuuaa gccuuuugac cuggucauuc cguuugcugu caggaaagga gaaaucacug     5520

gagaggucca caugccuucu gggaagacag ccacaccuga gauuguggac aacaaggacg     5580

gcacggucac uguuagauau gcccccacug aggucgggcu ccaugagaug cacaucaaau     5640

acaugggcag ccacaucccu gagagcccac uccaguucua cgugaacuac cccaacagug     5700

gaaguguuuc ugcauacggu ccaggccucg uguauggagu ggccaacaaa acugccaccu     5760

ucaccaucgu cacagaggau gcaggagaag guggucugga cuuggcuauu gagggccccu     5820

caaaagcaga aaucagcugc auugacaaua aagaugggac augcacagug accuaccugc     5880

cgacucugcc aggcgacuac agcauucugg ucaaguacaa ugacaagcac aucccuggca     5940

gccccuucac agccaagauc acagaugaca gcaggcggug cucccaggug aaguugggcu     6000

cagccgcuga cuuccugcuc gacaucagug agacugaccu cagcagccug acggccagca     6060

uuaaggcccc aucuggccga gacgagcccu gucuccugaa gaggcugccc aacaaccaca     6120

uuggcaucuc cuucaucccc cgggaagugg gcgaacaucu ggucagcauc aagaaaaaug     6180

gcaaccaugu ggccaacagc cccgugucua ucaugguggu ccagucggag auuggugacg     6240

cccgccgagc caaagucuau ggccgcggcc ugucagaagg ccggacuuuc gagaugucug     6300

acuucaucgu ggacacaagg gaugcagguu augguggcau auccuuggcg guggaaggcc     6360

ccagcaaagu ggacauccag acggaggacc uggaagaugg caccugcaaa gucuccuacu     6420

ucccuaccgu gccugggguu uauaucgucu ccaccaaauu cgcugacgag cacgugccug     6480

ggagcccauu uaccgugaag aucagugggg agggaagagu caaagagagc aucacccgca     6540

ccagucgggc cccguccgug gccacugucg ggagcauuug ugaccugaac cugaaaaucc     6600

cagaaaucaa cagcagugau augucggccc acgucaccag ccccucuggc cgugugacug     6660

aggcagagau ugugcccaug gggaagaacu cacacugcgu ccgguuugug ccccaggaga     6720

ugggcgugca cacggucagc gucaaguacc gugggcagca cgucaccggc agccccuucc     6780

aguucaccgu ggggccacuu ggugaaggag gcgcccacaa ggugcgggca ggaggcccug     6840

gccuggagag aggagaagcg ggagucccag cugaguucag cauuuggacc cgggaagcag     6900

gcgcuggagg ccucuccauc gcuguugagg gccccaguaa ggccgagauu acauucgaug     6960

accauaaaaa ugggucgugc gguguaucuu auauugccca agagccuggu aacuacgagg     7020

uguccaucaa guucaaugau gagcacaucc cggaaagccc cuaccuggug ccggucaucg     7080

cacccuccga cgacgcccgc cgccucacug uuaugagccu ucaggaaucg ggauuaaaag     7140

uuaaccagcc agcauccuuu gcuauaaggu ugaauggcgc aaaaggcaag auugaugcaa     7200

aggugcacag ccccucugga gccguggagg agugccacgu gucugagcug gagccagaua     7260

aguaugcugu ucgcuucauc ccucaugaga auggugucca caccaucgau gucaaguuca     7320

augggagcca cgugguugga agccccuuca aagugcgcgu uggggagccu ggacaagcgg     7380

ggaacccugc ccuggugucc gccuauggca cgggacucga agggggcacc acagguaucc     7440

agucggaauu cuuuauuaac accacccgag cagguccagg gacauuaucc gucaccaucg     7500

aaggcccauc caagguuaaa auggauugcc aggaaacacc ugaaggguac aaagucaugu     7560

acacccccau ggcuccuggu aacuaccuga ucagcgucaa auacgguggg cccaaccaca     7620

ucgugggcag ucccuucaag gccaagguga caggccagcg ucuaguuagc ccuggcucag     7680

ccaacgagac cucauccauc cugguggagu cagugaccag gucgucuaca gagaccugcu     7740

auagcgccau ucccaaggca uccucggacg ccagcaaggu gaccucuaag ggggcagggc     7800

ucucaaaggc cuuugugggc cagaagaguu ccuuccuggu ggacugcagc aaagcuggcu     7860

ccaacaugcu gcugaucggg guccaugggc ccaccacccc cugcgaggag gucuccauga     7920

agcauguagg caaccagcaa uacaacguca cauacgucgu caaggagagg ggcgauuaug     7980

ugcuggcugu gaaguggggg gaggaacaca ucccuggcag cccuuuucau gucacagugc     8040

cuuaaaacag uuuucucaaa uccuggagag aguucuugug guugcuuuug uugcuuguuu     8100

guaauucauu uuauacaaag cccuccagcc uguuuguggg gcugaaaccc caucccuaaa     8160

auauugcugu uguaaaaugc cuucagaaau aaguccuaga cuggacucuu gagggacaua     8220

uuggagaauc uuaagaaaug caagcuuguu cagggggcug agaagauccu gaguacacua     8280

ggugcaaacc agaacucuug guggaacaga ccagccacug cagcagacag accaggaaca     8340

caaugagacu gacauuucaa aaaaacaaaa cuggcuagcc ugagcugcug guucacucuu     8400

cagcauuuau gaaacaaggc uaggggaaga ugggcagaga aaaaggggac accuaguuug     8460

guugucauuu ggcaaaggag augacuuaaa auccgcuuaa ucucuuccag uguccguguu     8520

aauguauuug gcuauuagau cacuagcacu gcuuuaccgc uccucaucgc caacaccccc     8580

augcucugug gccuucuuac acuucucaga gggcagagug gcagccgggc acccuacaga     8640

aacucagagg gcagaguggc agccaggccc acaugucucu caaguaccug uccccucgcu     8700

cuggugauua uuucuugcag aaucaccaca cgagaccauc ccggcaguca ugguuuugcu     8760

uuaguuuucc aaguccguuu cagucccuuc cuuggucuga agaaauucug caguggcgag     8820

caguuuccca cuugccaaag aucccuuuua accaacacua gcccuuguuu uuaacacacg     8880

cuccagcccu ucaucagccu gggcagucuu accaaaaugu uuaaagugau cucagagggg     8940

cccauggauu aacgcccuca ucccaagguc cgucccauga cauaacacuc cacacccgcc     9000

ccagccaacu ucauggguca cuuuuucugg aaaauaauga ucuguacaga caggacagaa     9060

ugaaacuccu gcgggucuuu ggccugaaag uugggaaugg uugggggaga gaagggcagc     9120

agcuuauugg uggucuuuuc accauuggca gaaacaguga gagcugugug gugcagaaau     9180

ccagaaauga gguguaggga auuuugccug ccuuccugca gaccugagcu ggcuuuggaa     9240

ugagguuaaa gugucaggga cguugccuga gcccaaaugu guaguguggu cugggcaggc     9300

agaccuuuag guuuugcugc uuaguccuga ggaaguggcc acucuugugg cagguguagu     9360

aucuggggcg aguguugggg guaaaagccc acccuacaga aaguggaaca gcccggagcc     9420

ugaugugaaa ggaccacggg uguuguaagc ugggacacgg aagccaaacu ggaaucaaac     9480

gccgacugua aauuguaucu uauaacuuau uaaauaaaac auuugcuccg uaaa           9534


<210> 10
<211> 45
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic oligonucleotide

<400> 10
gggugguuuu ucucgguguc ucauccgaag gcuagaaaca guggg                     45


<210> 11
<211> 63
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic oligonucleotide

<400> 11
ggagccccag gugggugguu uuucucggug ucucauccga aggcuagaaa caguggggcg     60

gcg                                                                   63


<210> 12
<211> 43
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic oligonucleotide

<400> 12
gguugaccuu uagcccugac cuccgaaggc uagaaacagu ggg                       43


<210> 13
<211> 65
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic oligonucleotide

<400> 13
gcaaaagagg cuggcugguu gaccuuuagc ccugaccucc gaaggcuaga aacagugggg     60

cggcg                                                                 65


<210> 14
<211> 46
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic oligonucleotide

<400> 14
agauggaugc uuccuugcau cucacccgaa ggcucauaac agugag                    46


<210> 15
<211> 64
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic oligonucleotide

<400> 15
cggccaagga gauggaugcu uccuugcauc ucacccgaag gcucauaaca gugaggcggc     60

gggc                                                                  64


<210> 16
<211> 43
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic oligonucleotide

<400> 16
gguuaacuuu uaaucccgau ucccgaaggc ucauaacagu gag                       43


<210> 17
<211> 63
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic oligonucleotide

<400> 17
ggaugcuggc ugguuaacuu uuaaucccga uucccgaagg cucauaacag ugaggcggcg     60

ggc                                                                   63


<210> 18
<211> 100
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic oligonucleotide

<400> 18
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acaccgggug     60

guuuuucucg gugucucauc cgaaggcuag aaacaguggg                          100


<210> 19
<211> 118
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic oligonucleotide

<400> 19
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acaccggagc     60

cccagguggg ugguuuuucu cggugucuca uccgaaggcu agaaacagug gggcggcg      118


<210> 20
<211> 98
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic oligonucleotide

<400> 20
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acaccgguug     60

accuuuagcc cugaccuccg aaggcuagaa acaguggg                             98


<210> 21
<211> 120
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic oligonucleotide

<400> 21
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acaccgcaaa     60

agaggcuggc ugguugaccu uuagcccuga ccuccgaagg cuagaaacag uggggcggcg    120


<210> 22
<211> 101
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic oligonucleotide

<400> 22
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acaccagaug     60

gaugcuuccu ugcaucucac ccgaaggcuc auaacaguga g                        101


<210> 23
<211> 119
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic oligonucleotide

<400> 23
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acacccggcc     60

aaggagaugg augcuuccuu gcaucucacc cgaaggcuca uaacagugag gcggcgggc     119


<210> 24
<211> 98
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic oligonucleotide

<400> 24
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acaccgguua     60

acuuuuaauc ccgauucccg aaggcucaua acagugag                             98


<210> 25
<211> 118
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic oligonucleotide

<400> 25
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acaccggaug     60

cuggcugguu aacuuuuaau cccgauuccc gaaggcucau aacagugagg cggcgggc      118


<210> 26
<211> 55
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic oligonucleotide

<400> 26
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acacc          55


<210> 27
<211> 2639
<212> PRT
<213> Homo sapiens


<220> 
<223> filamin-A isoform 1 unmodified

<400> 27
Met Ser Ser Ser His Ser Arg Ala Gly Gln Ser Ala Ala Gly Ala Ala 
1               5                   10                  15      
Pro Gly Gly Gly Val Asp Thr Arg Asp Ala Glu Met Pro Ala Thr Glu 
            20                  25                  30          
Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys Ile Gln Gln Asn Thr 
        35                  40                  45              
Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys Val Ser Lys Arg Ile 
    50                  55                  60                  
Ala Asn Leu Gln Thr Asp Leu Ser Asp Gly Leu Arg Leu Ile Ala Leu 
65                  70                  75                  80  
Leu Glu Val Leu Ser Gln Lys Lys Met His Arg Lys His Asn Gln Arg 
                85                  90                  95      
Pro Thr Phe Arg Gln Met Gln Leu Glu Asn Val Ser Val Ala Leu Glu 
            100                 105                 110         
Phe Leu Asp Arg Glu Ser Ile Lys Leu Val Ser Ile Asp Ser Lys Ala 
        115                 120                 125             
Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly Leu Ile Trp Thr Leu 
    130                 135                 140                 
Ile Leu His Tyr Ser Ile Ser Met Pro Met Trp Asp Glu Glu Glu Asp 
145                 150                 155                 160 
Glu Glu Ala Lys Lys Gln Thr Pro Lys Gln Arg Leu Leu Gly Trp Ile 
                165                 170                 175     
Gln Asn Lys Leu Pro Gln Leu Pro Ile Thr Asn Phe Ser Arg Asp Trp 
            180                 185                 190         
Gln Ser Gly Arg Ala Leu Gly Ala Leu Val Asp Ser Cys Ala Pro Gly 
        195                 200                 205             
Leu Cys Pro Asp Trp Asp Ser Trp Asp Ala Ser Lys Pro Val Thr Asn 
    210                 215                 220                 
Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp Leu Gly Ile Pro Gln 
225                 230                 235                 240 
Val Ile Thr Pro Glu Glu Ile Val Asp Pro Asn Val Asp Glu His Ser 
                245                 250                 255     
Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala Lys Leu Lys Pro Gly 
            260                 265                 270         
Ala Pro Leu Arg Pro Lys Leu Asn Pro Lys Lys Ala Arg Ala Tyr Gly 
        275                 280                 285             
Pro Gly Ile Glu Pro Thr Gly Asn Met Val Lys Lys Arg Ala Glu Phe 
    290                 295                 300                 
Thr Val Glu Thr Arg Ser Ala Gly Gln Gly Glu Val Leu Val Tyr Val 
305                 310                 315                 320 
Glu Asp Pro Ala Gly His Gln Glu Glu Ala Lys Val Thr Ala Asn Asn 
                325                 330                 335     
Asp Lys Asn Arg Thr Phe Ser Val Trp Tyr Val Pro Glu Val Thr Gly 
            340                 345                 350         
Thr His Lys Val Thr Val Leu Phe Ala Gly Gln His Ile Ala Lys Ser 
        355                 360                 365             
Pro Phe Glu Val Tyr Val Asp Lys Ser Gln Gly Asp Ala Ser Lys Val 
    370                 375                 380                 
Thr Ala Gln Gly Pro Gly Leu Glu Pro Ser Gly Asn Ile Ala Asn Lys 
385                 390                 395                 400 
Thr Thr Tyr Phe Glu Ile Phe Thr Ala Gly Ala Gly Thr Gly Glu Val 
                405                 410                 415     
Glu Val Val Ile Gln Asp Pro Met Gly Gln Lys Gly Thr Val Glu Pro 
            420                 425                 430         
Gln Leu Glu Ala Arg Gly Asp Ser Thr Tyr Arg Cys Ser Tyr Gln Pro 
        435                 440                 445             
Thr Met Glu Gly Val His Thr Val His Val Thr Phe Ala Gly Val Pro 
    450                 455                 460                 
Ile Pro Arg Ser Pro Tyr Thr Val Thr Val Gly Gln Ala Cys Asn Pro 
465                 470                 475                 480 
Ser Ala Cys Arg Ala Val Gly Arg Gly Leu Gln Pro Lys Gly Val Arg 
                485                 490                 495     
Val Lys Glu Thr Ala Asp Phe Lys Val Tyr Thr Lys Gly Ala Gly Ser 
            500                 505                 510         
Gly Glu Leu Lys Val Thr Val Lys Gly Pro Lys Gly Glu Glu Arg Val 
        515                 520                 525             
Lys Gln Lys Asp Leu Gly Asp Gly Val Tyr Gly Phe Glu Tyr Tyr Pro 
    530                 535                 540                 
Met Val Pro Gly Thr Tyr Ile Val Thr Ile Thr Trp Gly Gly Gln Asn 
545                 550                 555                 560 
Ile Gly Arg Ser Pro Phe Glu Val Lys Val Gly Thr Glu Cys Gly Asn 
                565                 570                 575     
Gln Lys Val Arg Ala Trp Gly Pro Gly Leu Glu Gly Gly Val Val Gly 
            580                 585                 590         
Lys Ser Ala Asp Phe Val Val Glu Ala Ile Gly Asp Asp Val Gly Thr 
        595                 600                 605             
Leu Gly Phe Ser Val Glu Gly Pro Ser Gln Ala Lys Ile Glu Cys Asp 
    610                 615                 620                 
Asp Lys Gly Asp Gly Ser Cys Asp Val Arg Tyr Trp Pro Gln Glu Ala 
625                 630                 635                 640 
Gly Glu Tyr Ala Val His Val Leu Cys Asn Ser Glu Asp Ile Arg Leu 
                645                 650                 655     
Ser Pro Phe Met Ala Asp Ile Arg Asp Ala Pro Gln Asp Phe His Pro 
            660                 665                 670         
Asp Arg Val Lys Ala Arg Gly Pro Gly Leu Glu Lys Thr Gly Val Ala 
        675                 680                 685             
Val Asn Lys Pro Ala Glu Phe Thr Val Asp Ala Lys His Gly Gly Lys 
    690                 695                 700                 
Ala Pro Leu Arg Val Gln Val Gln Asp Asn Glu Gly Cys Pro Val Glu 
705                 710                 715                 720 
Ala Leu Val Lys Asp Asn Gly Asn Gly Thr Tyr Ser Cys Ser Tyr Val 
                725                 730                 735     
Pro Arg Lys Pro Val Lys His Thr Ala Met Val Ser Trp Gly Gly Val 
            740                 745                 750         
Ser Ile Pro Asn Ser Pro Phe Arg Val Asn Val Gly Ala Gly Ser His 
        755                 760                 765             
Pro Asn Lys Val Lys Val Tyr Gly Pro Gly Val Ala Lys Thr Gly Leu 
    770                 775                 780                 
Lys Ala His Glu Pro Thr Tyr Phe Thr Val Asp Cys Ala Glu Ala Gly 
785                 790                 795                 800 
Gln Gly Asp Val Ser Ile Gly Ile Lys Cys Ala Pro Gly Val Val Gly 
                805                 810                 815     
Pro Ala Glu Ala Asp Ile Asp Phe Asp Ile Ile Arg Asn Asp Asn Asp 
            820                 825                 830         
Thr Phe Thr Val Lys Tyr Thr Pro Arg Gly Ala Gly Ser Tyr Thr Ile 
        835                 840                 845             
Met Val Leu Phe Ala Asp Gln Ala Thr Pro Thr Ser Pro Ile Arg Val 
    850                 855                 860                 
Lys Val Glu Pro Ser His Asp Ala Ser Lys Val Lys Ala Glu Gly Pro 
865                 870                 875                 880 
Gly Leu Ser Arg Thr Gly Val Glu Leu Gly Lys Pro Thr His Phe Thr 
                885                 890                 895     
Val Asn Ala Lys Ala Ala Gly Lys Gly Lys Leu Asp Val Gln Phe Ser 
            900                 905                 910         
Gly Leu Thr Lys Gly Asp Ala Val Arg Asp Val Asp Ile Ile Asp His 
        915                 920                 925             
His Asp Asn Thr Tyr Thr Val Lys Tyr Thr Pro Val Gln Gln Gly Pro 
    930                 935                 940                 
Val Gly Val Asn Val Thr Tyr Gly Gly Asp Pro Ile Pro Lys Ser Pro 
945                 950                 955                 960 
Phe Ser Val Ala Val Ser Pro Ser Leu Asp Leu Ser Lys Ile Lys Val 
                965                 970                 975     
Ser Gly Leu Gly Glu Lys Val Asp Val Gly Lys Asp Gln Glu Phe Thr 
            980                 985                 990         
Val Lys Ser Lys Gly Ala Gly Gly Gln Gly Lys Val Ala Ser Lys Ile 
        995                 1000                1005            
Val Gly Pro Ser Gly Ala Ala Val Pro Cys Lys Val Glu Pro Gly Leu 
    1010                1015                1020                
Gly Ala Asp Asn Ser Val Val Arg Phe Leu Pro Arg Glu Glu Gly Pro 
1025                1030                1035                1040
Tyr Glu Val Glu Val Thr Tyr Asp Gly Val Pro Val Pro Gly Ser Pro 
                1045                1050                1055    
Phe Pro Leu Glu Ala Val Ala Pro Thr Lys Pro Ser Lys Val Lys Ala 
            1060                1065                1070        
Phe Gly Pro Gly Leu Gln Gly Gly Ser Ala Gly Ser Pro Ala Arg Phe 
        1075                1080                1085            
Thr Ile Asp Thr Lys Gly Ala Gly Thr Gly Gly Leu Gly Leu Thr Val 
    1090                1095                1100                
Glu Gly Pro Cys Glu Ala Gln Leu Glu Cys Leu Asp Asn Gly Asp Gly 
1105                1110                1115                1120
Thr Cys Ser Val Ser Tyr Val Pro Thr Glu Pro Gly Asp Tyr Asn Ile 
                1125                1130                1135    
Asn Ile Leu Phe Ala Asp Thr His Ile Pro Gly Ser Pro Phe Lys Ala 
            1140                1145                1150        
His Val Val Pro Cys Phe Asp Ala Ser Lys Val Lys Cys Ser Gly Pro 
        1155                1160                1165            
Gly Leu Glu Arg Ala Thr Ala Gly Glu Val Gly Gln Phe Gln Val Asp 
    1170                1175                1180                
Cys Ser Ser Ala Gly Ser Ala Glu Leu Thr Ile Glu Ile Cys Ser Glu 
1185                1190                1195                1200
Ala Gly Leu Pro Ala Glu Val Tyr Ile Gln Asp His Gly Asp Gly Thr 
                1205                1210                1215    
His Thr Ile Thr Tyr Ile Pro Leu Cys Pro Gly Ala Tyr Thr Val Thr 
            1220                1225                1230        
Ile Lys Tyr Gly Gly Gln Pro Val Pro Asn Phe Pro Ser Lys Leu Gln 
        1235                1240                1245            
Val Glu Pro Ala Val Asp Thr Ser Gly Val Gln Cys Tyr Gly Pro Gly 
    1250                1255                1260                
Ile Glu Gly Gln Gly Val Phe Arg Glu Ala Thr Thr Glu Phe Ser Val 
1265                1270                1275                1280
Asp Ala Arg Ala Leu Thr Gln Thr Gly Gly Pro His Val Lys Ala Arg 
                1285                1290                1295    
Val Ala Asn Pro Ser Gly Asn Leu Thr Glu Thr Tyr Val Gln Asp Arg 
            1300                1305                1310        
Gly Asp Gly Met Tyr Lys Val Glu Tyr Thr Pro Tyr Glu Glu Gly Leu 
        1315                1320                1325            
His Ser Val Asp Val Thr Tyr Asp Gly Ser Pro Val Pro Ser Ser Pro 
    1330                1335                1340                
Phe Gln Val Pro Val Thr Glu Gly Cys Asp Pro Ser Arg Val Arg Val 
1345                1350                1355                1360
His Gly Pro Gly Ile Gln Ser Gly Thr Thr Asn Lys Pro Asn Lys Phe 
                1365                1370                1375    
Thr Val Glu Thr Arg Gly Ala Gly Thr Gly Gly Leu Gly Leu Ala Val 
            1380                1385                1390        
Glu Gly Pro Ser Glu Ala Lys Met Ser Cys Met Asp Asn Lys Asp Gly 
        1395                1400                1405            
Ser Cys Ser Val Glu Tyr Ile Pro Tyr Glu Ala Gly Thr Tyr Ser Leu 
    1410                1415                1420                
Asn Val Thr Tyr Gly Gly His Gln Val Pro Gly Ser Pro Phe Lys Val 
1425                1430                1435                1440
Pro Val His Asp Val Thr Asp Ala Ser Lys Val Lys Cys Ser Gly Pro 
                1445                1450                1455    
Gly Leu Ser Pro Gly Met Val Arg Ala Asn Leu Pro Gln Ser Phe Gln 
            1460                1465                1470        
Val Asp Thr Ser Lys Ala Gly Val Ala Pro Leu Gln Val Lys Val Gln 
        1475                1480                1485            
Gly Pro Lys Gly Leu Val Glu Pro Val Asp Val Val Asp Asn Ala Asp 
    1490                1495                1500                
Gly Thr Gln Thr Val Asn Tyr Val Pro Ser Arg Glu Gly Pro Tyr Ser 
1505                1510                1515                1520
Ile Ser Val Leu Tyr Gly Asp Glu Glu Val Pro Arg Ser Pro Phe Lys 
                1525                1530                1535    
Val Lys Val Leu Pro Thr His Asp Ala Ser Lys Val Lys Ala Ser Gly 
            1540                1545                1550        
Pro Gly Leu Asn Thr Thr Gly Val Pro Ala Ser Leu Pro Val Glu Phe 
        1555                1560                1565            
Thr Ile Asp Ala Lys Asp Ala Gly Glu Gly Leu Leu Ala Val Gln Ile 
    1570                1575                1580                
Thr Asp Pro Glu Gly Lys Pro Lys Lys Thr His Ile Gln Asp Asn His 
1585                1590                1595                1600
Asp Gly Thr Tyr Thr Val Ala Tyr Val Pro Asp Val Thr Gly Arg Tyr 
                1605                1610                1615    
Thr Ile Leu Ile Lys Tyr Gly Gly Asp Glu Ile Pro Phe Ser Pro Tyr 
            1620                1625                1630        
Arg Val Arg Ala Val Pro Thr Gly Asp Ala Ser Lys Cys Thr Val Thr 
        1635                1640                1645            
Gly Ala Gly Ile Gly Pro Thr Ile Gln Ile Gly Glu Glu Thr Val Ile 
    1650                1655                1660                
Thr Val Asp Thr Lys Ala Ala Gly Lys Gly Lys Val Thr Cys Thr Val 
1665                1670                1675                1680
Cys Thr Pro Asp Gly Ser Glu Val Asp Val Asp Val Val Glu Asn Glu 
                1685                1690                1695    
Asp Gly Thr Phe Asp Ile Phe Tyr Thr Ala Pro Gln Pro Gly Lys Tyr 
            1700                1705                1710        
Val Ile Cys Val Arg Phe Gly Gly Glu His Val Pro Asn Ser Pro Phe 
        1715                1720                1725            
Gln Val Thr Ala Leu Ala Gly Asp Gln Pro Ser Val Gln Pro Pro Leu 
    1730                1735                1740                
Arg Ser Gln Gln Leu Ala Pro Gln Tyr Thr Tyr Ala Gln Gly Gly Gln 
1745                1750                1755                1760
Gln Thr Trp Ala Pro Glu Arg Pro Leu Val Gly Val Asn Gly Leu Asp 
                1765                1770                1775    
Val Thr Ser Leu Arg Pro Phe Asp Leu Val Ile Pro Phe Thr Ile Lys 
            1780                1785                1790        
Lys Gly Glu Ile Thr Gly Glu Val Arg Met Pro Ser Gly Lys Val Ala 
        1795                1800                1805            
Gln Pro Thr Ile Thr Asp Asn Lys Asp Gly Thr Val Thr Val Arg Tyr 
    1810                1815                1820                
Ala Pro Ser Glu Ala Gly Leu His Glu Met Asp Ile Arg Tyr Asp Asn 
1825                1830                1835                1840
Met His Ile Pro Gly Ser Pro Leu Gln Phe Tyr Val Asp Tyr Val Asn 
                1845                1850                1855    
Cys Gly His Val Thr Ala Tyr Gly Pro Gly Leu Thr His Gly Val Val 
            1860                1865                1870        
Asn Lys Pro Ala Thr Phe Thr Val Asn Thr Lys Asp Ala Gly Glu Gly 
        1875                1880                1885            
Gly Leu Ser Leu Ala Ile Glu Gly Pro Ser Lys Ala Glu Ile Ser Cys 
    1890                1895                1900                
Thr Asp Asn Gln Asp Gly Thr Cys Ser Val Ser Tyr Leu Pro Val Leu 
1905                1910                1915                1920
Pro Gly Asp Tyr Ser Ile Leu Val Lys Tyr Asn Glu Gln His Val Pro 
                1925                1930                1935    
Gly Ser Pro Phe Thr Ala Arg Val Thr Gly Asp Asp Ser Met Arg Met 
            1940                1945                1950        
Ser His Leu Lys Val Gly Ser Ala Ala Asp Ile Pro Ile Asn Ile Ser 
        1955                1960                1965            
Glu Thr Asp Leu Ser Leu Leu Thr Ala Thr Val Val Pro Pro Ser Gly 
    1970                1975                1980                
Arg Glu Glu Pro Cys Leu Leu Lys Arg Leu Arg Asn Gly His Val Gly 
1985                1990                1995                2000
Ile Ser Phe Val Pro Lys Glu Thr Gly Glu His Leu Val His Val Lys 
                2005                2010                2015    
Lys Asn Gly Gln His Val Ala Ser Ser Pro Ile Pro Val Val Ile Ser 
            2020                2025                2030        
Gln Ser Glu Ile Gly Asp Ala Ser Arg Val Arg Val Ser Gly Gln Gly 
        2035                2040                2045            
Leu His Glu Gly His Thr Phe Glu Pro Ala Glu Phe Ile Ile Asp Thr 
    2050                2055                2060                
Arg Asp Ala Gly Tyr Gly Gly Leu Ser Leu Ser Ile Glu Gly Pro Ser 
2065                2070                2075                2080
Lys Val Asp Ile Asn Thr Glu Asp Leu Glu Asp Gly Thr Cys Arg Val 
                2085                2090                2095    
Thr Tyr Cys Pro Thr Glu Pro Gly Asn Tyr Ile Ile Asn Ile Lys Phe 
            2100                2105                2110        
Ala Asp Gln His Val Pro Gly Ser Pro Phe Ser Val Lys Val Thr Gly 
        2115                2120                2125            
Glu Gly Arg Val Lys Glu Ser Ile Thr Arg Arg Arg Arg Ala Pro Ser 
    2130                2135                2140                
Val Ala Asn Val Gly Ser His Cys Asp Leu Ser Leu Lys Ile Pro Glu 
2145                2150                2155                2160
Ile Ser Ile Gln Asp Met Thr Ala Gln Val Thr Ser Pro Ser Gly Lys 
                2165                2170                2175    
Thr His Glu Ala Glu Ile Val Glu Gly Glu Asn His Thr Tyr Cys Ile 
            2180                2185                2190        
Arg Phe Val Pro Ala Glu Met Gly Thr His Thr Val Ser Val Lys Tyr 
        2195                2200                2205            
Lys Gly Gln His Val Pro Gly Ser Pro Phe Gln Phe Thr Val Gly Pro 
    2210                2215                2220                
Leu Gly Glu Gly Gly Ala His Lys Val Arg Ala Gly Gly Pro Gly Leu 
2225                2230                2235                2240
Glu Arg Ala Glu Ala Gly Val Pro Ala Glu Phe Ser Ile Trp Thr Arg 
                2245                2250                2255    
Glu Ala Gly Ala Gly Gly Leu Ala Ile Ala Val Glu Gly Pro Ser Lys 
            2260                2265                2270        
Ala Glu Ile Ser Phe Glu Asp Arg Lys Asp Gly Ser Cys Gly Val Ala 
        2275                2280                2285            
Tyr Val Val Gln Glu Pro Gly Asp Tyr Glu Val Ser Val Lys Phe Asn 
    2290                2295                2300                
Glu Glu His Ile Pro Asp Ser Pro Phe Val Val Pro Val Ala Ser Pro 
2305                2310                2315                2320
Ser Gly Asp Ala Arg Arg Leu Thr Val Ser Ser Leu Gln Glu Ser Gly 
                2325                2330                2335    
Leu Lys Val Asn Gln Pro Ala Ser Phe Ala Val Ser Leu Asn Gly Ala 
            2340                2345                2350        
Lys Gly Ala Ile Asp Ala Lys Val His Ser Pro Ser Gly Ala Leu Glu 
        2355                2360                2365            
Glu Cys Tyr Val Thr Glu Ile Asp Gln Asp Lys Tyr Ala Val Arg Phe 
    2370                2375                2380                
Ile Pro Arg Glu Asn Gly Val Tyr Leu Ile Asp Val Lys Phe Asn Gly 
2385                2390                2395                2400
Thr His Ile Pro Gly Ser Pro Phe Lys Ile Arg Val Gly Glu Pro Gly 
                2405                2410                2415    
His Gly Gly Asp Pro Gly Leu Val Ser Ala Tyr Gly Ala Gly Leu Glu 
            2420                2425                2430        
Gly Gly Val Thr Gly Asn Pro Ala Glu Phe Val Val Asn Thr Ser Asn 
        2435                2440                2445            
Ala Gly Ala Gly Ala Leu Ser Val Thr Ile Asp Gly Pro Ser Lys Val 
    2450                2455                2460                
Lys Met Asp Cys Gln Glu Cys Pro Glu Gly Tyr Arg Val Thr Tyr Thr 
2465                2470                2475                2480
Pro Met Ala Pro Gly Ser Tyr Leu Ile Ser Ile Lys Tyr Gly Gly Pro 
                2485                2490                2495    
Tyr His Ile Gly Gly Ser Pro Phe Lys Ala Lys Val Thr Gly Pro Arg 
            2500                2505                2510        
Leu Val Ser Asn His Ser Leu His Glu Thr Ser Ser Val Phe Val Asp 
        2515                2520                2525            
Ser Leu Thr Lys Ala Thr Cys Ala Pro Gln His Gly Ala Pro Gly Pro 
    2530                2535                2540                
Gly Pro Ala Asp Ala Ser Lys Val Val Ala Lys Gly Leu Gly Leu Ser 
2545                2550                2555                2560
Lys Ala Tyr Val Gly Gln Lys Ser Ser Phe Thr Val Asp Cys Ser Lys 
                2565                2570                2575    
Ala Gly Asn Asn Met Leu Leu Val Gly Val His Gly Pro Arg Thr Pro 
            2580                2585                2590        
Cys Glu Glu Ile Leu Val Lys His Val Gly Ser Arg Leu Tyr Ser Val 
        2595                2600                2605            
Ser Tyr Leu Leu Lys Asp Lys Gly Glu Tyr Thr Leu Val Val Lys Trp 
    2610                2615                2620                
Gly Asp Glu His Ile Pro Gly Ser Pro Tyr Arg Val Val Val Pro 
2625                2630                2635                

<210> 28
<211> 2647
<212> PRT
<213> Homo sapiens


<220> 
<223> filamin-A isoform 2 unmodified

<400> 28
Met Ser Ser Ser His Ser Arg Ala Gly Gln Ser Ala Ala Gly Ala Ala 
1               5                   10                  15      
Pro Gly Gly Gly Val Asp Thr Arg Asp Ala Glu Met Pro Ala Thr Glu 
            20                  25                  30          
Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys Ile Gln Gln Asn Thr 
        35                  40                  45              
Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys Val Ser Lys Arg Ile 
    50                  55                  60                  
Ala Asn Leu Gln Thr Asp Leu Ser Asp Gly Leu Arg Leu Ile Ala Leu 
65                  70                  75                  80  
Leu Glu Val Leu Ser Gln Lys Lys Met His Arg Lys His Asn Gln Arg 
                85                  90                  95      
Pro Thr Phe Arg Gln Met Gln Leu Glu Asn Val Ser Val Ala Leu Glu 
            100                 105                 110         
Phe Leu Asp Arg Glu Ser Ile Lys Leu Val Ser Ile Asp Ser Lys Ala 
        115                 120                 125             
Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly Leu Ile Trp Thr Leu 
    130                 135                 140                 
Ile Leu His Tyr Ser Ile Ser Met Pro Met Trp Asp Glu Glu Glu Asp 
145                 150                 155                 160 
Glu Glu Ala Lys Lys Gln Thr Pro Lys Gln Arg Leu Leu Gly Trp Ile 
                165                 170                 175     
Gln Asn Lys Leu Pro Gln Leu Pro Ile Thr Asn Phe Ser Arg Asp Trp 
            180                 185                 190         
Gln Ser Gly Arg Ala Leu Gly Ala Leu Val Asp Ser Cys Ala Pro Gly 
        195                 200                 205             
Leu Cys Pro Asp Trp Asp Ser Trp Asp Ala Ser Lys Pro Val Thr Asn 
    210                 215                 220                 
Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp Leu Gly Ile Pro Gln 
225                 230                 235                 240 
Val Ile Thr Pro Glu Glu Ile Val Asp Pro Asn Val Asp Glu His Ser 
                245                 250                 255     
Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala Lys Leu Lys Pro Gly 
            260                 265                 270         
Ala Pro Leu Arg Pro Lys Leu Asn Pro Lys Lys Ala Arg Ala Tyr Gly 
        275                 280                 285             
Pro Gly Ile Glu Pro Thr Gly Asn Met Val Lys Lys Arg Ala Glu Phe 
    290                 295                 300                 
Thr Val Glu Thr Arg Ser Ala Gly Gln Gly Glu Val Leu Val Tyr Val 
305                 310                 315                 320 
Glu Asp Pro Ala Gly His Gln Glu Glu Ala Lys Val Thr Ala Asn Asn 
                325                 330                 335     
Asp Lys Asn Arg Thr Phe Ser Val Trp Tyr Val Pro Glu Val Thr Gly 
            340                 345                 350         
Thr His Lys Val Thr Val Leu Phe Ala Gly Gln His Ile Ala Lys Ser 
        355                 360                 365             
Pro Phe Glu Val Tyr Val Asp Lys Ser Gln Gly Asp Ala Ser Lys Val 
    370                 375                 380                 
Thr Ala Gln Gly Pro Gly Leu Glu Pro Ser Gly Asn Ile Ala Asn Lys 
385                 390                 395                 400 
Thr Thr Tyr Phe Glu Ile Phe Thr Ala Gly Ala Gly Thr Gly Glu Val 
                405                 410                 415     
Glu Val Val Ile Gln Asp Pro Met Gly Gln Lys Gly Thr Val Glu Pro 
            420                 425                 430         
Gln Leu Glu Ala Arg Gly Asp Ser Thr Tyr Arg Cys Ser Tyr Gln Pro 
        435                 440                 445             
Thr Met Glu Gly Val His Thr Val His Val Thr Phe Ala Gly Val Pro 
    450                 455                 460                 
Ile Pro Arg Ser Pro Tyr Thr Val Thr Val Gly Gln Ala Cys Asn Pro 
465                 470                 475                 480 
Ser Ala Cys Arg Ala Val Gly Arg Gly Leu Gln Pro Lys Gly Val Arg 
                485                 490                 495     
Val Lys Glu Thr Ala Asp Phe Lys Val Tyr Thr Lys Gly Ala Gly Ser 
            500                 505                 510         
Gly Glu Leu Lys Val Thr Val Lys Gly Pro Lys Gly Glu Glu Arg Val 
        515                 520                 525             
Lys Gln Lys Asp Leu Gly Asp Gly Val Tyr Gly Phe Glu Tyr Tyr Pro 
    530                 535                 540                 
Met Val Pro Gly Thr Tyr Ile Val Thr Ile Thr Trp Gly Gly Gln Asn 
545                 550                 555                 560 
Ile Gly Arg Ser Pro Phe Glu Val Lys Val Gly Thr Glu Cys Gly Asn 
                565                 570                 575     
Gln Lys Val Arg Ala Trp Gly Pro Gly Leu Glu Gly Gly Val Val Gly 
            580                 585                 590         
Lys Ser Ala Asp Phe Val Val Glu Ala Ile Gly Asp Asp Val Gly Thr 
        595                 600                 605             
Leu Gly Phe Ser Val Glu Gly Pro Ser Gln Ala Lys Ile Glu Cys Asp 
    610                 615                 620                 
Asp Lys Gly Asp Gly Ser Cys Asp Val Arg Tyr Trp Pro Gln Glu Ala 
625                 630                 635                 640 
Gly Glu Tyr Ala Val His Val Leu Cys Asn Ser Glu Asp Ile Arg Leu 
                645                 650                 655     
Ser Pro Phe Met Ala Asp Ile Arg Asp Ala Pro Gln Asp Phe His Pro 
            660                 665                 670         
Asp Arg Val Lys Ala Arg Gly Pro Gly Leu Glu Lys Thr Gly Val Ala 
        675                 680                 685             
Val Asn Lys Pro Ala Glu Phe Thr Val Asp Ala Lys His Gly Gly Lys 
    690                 695                 700                 
Ala Pro Leu Arg Val Gln Val Gln Asp Asn Glu Gly Cys Pro Val Glu 
705                 710                 715                 720 
Ala Leu Val Lys Asp Asn Gly Asn Gly Thr Tyr Ser Cys Ser Tyr Val 
                725                 730                 735     
Pro Arg Lys Pro Val Lys His Thr Ala Met Val Ser Trp Gly Gly Val 
            740                 745                 750         
Ser Ile Pro Asn Ser Pro Phe Arg Val Asn Val Gly Ala Gly Ser His 
        755                 760                 765             
Pro Asn Lys Val Lys Val Tyr Gly Pro Gly Val Ala Lys Thr Gly Leu 
    770                 775                 780                 
Lys Ala His Glu Pro Thr Tyr Phe Thr Val Asp Cys Ala Glu Ala Gly 
785                 790                 795                 800 
Gln Gly Asp Val Ser Ile Gly Ile Lys Cys Ala Pro Gly Val Val Gly 
                805                 810                 815     
Pro Ala Glu Ala Asp Ile Asp Phe Asp Ile Ile Arg Asn Asp Asn Asp 
            820                 825                 830         
Thr Phe Thr Val Lys Tyr Thr Pro Arg Gly Ala Gly Ser Tyr Thr Ile 
        835                 840                 845             
Met Val Leu Phe Ala Asp Gln Ala Thr Pro Thr Ser Pro Ile Arg Val 
    850                 855                 860                 
Lys Val Glu Pro Ser His Asp Ala Ser Lys Val Lys Ala Glu Gly Pro 
865                 870                 875                 880 
Gly Leu Ser Arg Thr Gly Val Glu Leu Gly Lys Pro Thr His Phe Thr 
                885                 890                 895     
Val Asn Ala Lys Ala Ala Gly Lys Gly Lys Leu Asp Val Gln Phe Ser 
            900                 905                 910         
Gly Leu Thr Lys Gly Asp Ala Val Arg Asp Val Asp Ile Ile Asp His 
        915                 920                 925             
His Asp Asn Thr Tyr Thr Val Lys Tyr Thr Pro Val Gln Gln Gly Pro 
    930                 935                 940                 
Val Gly Val Asn Val Thr Tyr Gly Gly Asp Pro Ile Pro Lys Ser Pro 
945                 950                 955                 960 
Phe Ser Val Ala Val Ser Pro Ser Leu Asp Leu Ser Lys Ile Lys Val 
                965                 970                 975     
Ser Gly Leu Gly Glu Lys Val Asp Val Gly Lys Asp Gln Glu Phe Thr 
            980                 985                 990         
Val Lys Ser Lys Gly Ala Gly Gly Gln Gly Lys Val Ala Ser Lys Ile 
        995                 1000                1005            
Val Gly Pro Ser Gly Ala Ala Val Pro Cys Lys Val Glu Pro Gly Leu 
    1010                1015                1020                
Gly Ala Asp Asn Ser Val Val Arg Phe Leu Pro Arg Glu Glu Gly Pro 
1025                1030                1035                1040
Tyr Glu Val Glu Val Thr Tyr Asp Gly Val Pro Val Pro Gly Ser Pro 
                1045                1050                1055    
Phe Pro Leu Glu Ala Val Ala Pro Thr Lys Pro Ser Lys Val Lys Ala 
            1060                1065                1070        
Phe Gly Pro Gly Leu Gln Gly Gly Ser Ala Gly Ser Pro Ala Arg Phe 
        1075                1080                1085            
Thr Ile Asp Thr Lys Gly Ala Gly Thr Gly Gly Leu Gly Leu Thr Val 
    1090                1095                1100                
Glu Gly Pro Cys Glu Ala Gln Leu Glu Cys Leu Asp Asn Gly Asp Gly 
1105                1110                1115                1120
Thr Cys Ser Val Ser Tyr Val Pro Thr Glu Pro Gly Asp Tyr Asn Ile 
                1125                1130                1135    
Asn Ile Leu Phe Ala Asp Thr His Ile Pro Gly Ser Pro Phe Lys Ala 
            1140                1145                1150        
His Val Val Pro Cys Phe Asp Ala Ser Lys Val Lys Cys Ser Gly Pro 
        1155                1160                1165            
Gly Leu Glu Arg Ala Thr Ala Gly Glu Val Gly Gln Phe Gln Val Asp 
    1170                1175                1180                
Cys Ser Ser Ala Gly Ser Ala Glu Leu Thr Ile Glu Ile Cys Ser Glu 
1185                1190                1195                1200
Ala Gly Leu Pro Ala Glu Val Tyr Ile Gln Asp His Gly Asp Gly Thr 
                1205                1210                1215    
His Thr Ile Thr Tyr Ile Pro Leu Cys Pro Gly Ala Tyr Thr Val Thr 
            1220                1225                1230        
Ile Lys Tyr Gly Gly Gln Pro Val Pro Asn Phe Pro Ser Lys Leu Gln 
        1235                1240                1245            
Val Glu Pro Ala Val Asp Thr Ser Gly Val Gln Cys Tyr Gly Pro Gly 
    1250                1255                1260                
Ile Glu Gly Gln Gly Val Phe Arg Glu Ala Thr Thr Glu Phe Ser Val 
1265                1270                1275                1280
Asp Ala Arg Ala Leu Thr Gln Thr Gly Gly Pro His Val Lys Ala Arg 
                1285                1290                1295    
Val Ala Asn Pro Ser Gly Asn Leu Thr Glu Thr Tyr Val Gln Asp Arg 
            1300                1305                1310        
Gly Asp Gly Met Tyr Lys Val Glu Tyr Thr Pro Tyr Glu Glu Gly Leu 
        1315                1320                1325            
His Ser Val Asp Val Thr Tyr Asp Gly Ser Pro Val Pro Ser Ser Pro 
    1330                1335                1340                
Phe Gln Val Pro Val Thr Glu Gly Cys Asp Pro Ser Arg Val Arg Val 
1345                1350                1355                1360
His Gly Pro Gly Ile Gln Ser Gly Thr Thr Asn Lys Pro Asn Lys Phe 
                1365                1370                1375    
Thr Val Glu Thr Arg Gly Ala Gly Thr Gly Gly Leu Gly Leu Ala Val 
            1380                1385                1390        
Glu Gly Pro Ser Glu Ala Lys Met Ser Cys Met Asp Asn Lys Asp Gly 
        1395                1400                1405            
Ser Cys Ser Val Glu Tyr Ile Pro Tyr Glu Ala Gly Thr Tyr Ser Leu 
    1410                1415                1420                
Asn Val Thr Tyr Gly Gly His Gln Val Pro Gly Ser Pro Phe Lys Val 
1425                1430                1435                1440
Pro Val His Asp Val Thr Asp Ala Ser Lys Val Lys Cys Ser Gly Pro 
                1445                1450                1455    
Gly Leu Ser Pro Gly Met Val Arg Ala Asn Leu Pro Gln Ser Phe Gln 
            1460                1465                1470        
Val Asp Thr Ser Lys Ala Gly Val Ala Pro Leu Gln Val Lys Val Gln 
        1475                1480                1485            
Gly Pro Lys Gly Leu Val Glu Pro Val Asp Val Val Asp Asn Ala Asp 
    1490                1495                1500                
Gly Thr Gln Thr Val Asn Tyr Val Pro Ser Arg Glu Gly Pro Tyr Ser 
1505                1510                1515                1520
Ile Ser Val Leu Tyr Gly Asp Glu Glu Val Pro Arg Ser Pro Phe Lys 
                1525                1530                1535    
Val Lys Val Leu Pro Thr His Asp Ala Ser Lys Val Lys Ala Ser Gly 
            1540                1545                1550        
Pro Gly Leu Asn Thr Thr Gly Val Pro Ala Ser Leu Pro Val Glu Phe 
        1555                1560                1565            
Thr Ile Asp Ala Lys Asp Ala Gly Glu Gly Leu Leu Ala Val Gln Ile 
    1570                1575                1580                
Thr Asp Pro Glu Gly Lys Pro Lys Lys Thr His Ile Gln Asp Asn His 
1585                1590                1595                1600
Asp Gly Thr Tyr Thr Val Ala Tyr Val Pro Asp Val Thr Gly Arg Tyr 
                1605                1610                1615    
Thr Ile Leu Ile Lys Tyr Gly Gly Asp Glu Ile Pro Phe Ser Pro Tyr 
            1620                1625                1630        
Arg Val Arg Ala Val Pro Thr Gly Asp Ala Ser Lys Cys Thr Val Thr 
        1635                1640                1645            
Val Ser Ile Gly Gly His Gly Leu Gly Ala Gly Ile Gly Pro Thr Ile 
    1650                1655                1660                
Gln Ile Gly Glu Glu Thr Val Ile Thr Val Asp Thr Lys Ala Ala Gly 
1665                1670                1675                1680
Lys Gly Lys Val Thr Cys Thr Val Cys Thr Pro Asp Gly Ser Glu Val 
                1685                1690                1695    
Asp Val Asp Val Val Glu Asn Glu Asp Gly Thr Phe Asp Ile Phe Tyr 
            1700                1705                1710        
Thr Ala Pro Gln Pro Gly Lys Tyr Val Ile Cys Val Arg Phe Gly Gly 
        1715                1720                1725            
Glu His Val Pro Asn Ser Pro Phe Gln Val Thr Ala Leu Ala Gly Asp 
    1730                1735                1740                
Gln Pro Ser Val Gln Pro Pro Leu Arg Ser Gln Gln Leu Ala Pro Gln 
1745                1750                1755                1760
Tyr Thr Tyr Ala Gln Gly Gly Gln Gln Thr Trp Ala Pro Glu Arg Pro 
                1765                1770                1775    
Leu Val Gly Val Asn Gly Leu Asp Val Thr Ser Leu Arg Pro Phe Asp 
            1780                1785                1790        
Leu Val Ile Pro Phe Thr Ile Lys Lys Gly Glu Ile Thr Gly Glu Val 
        1795                1800                1805            
Arg Met Pro Ser Gly Lys Val Ala Gln Pro Thr Ile Thr Asp Asn Lys 
    1810                1815                1820                
Asp Gly Thr Val Thr Val Arg Tyr Ala Pro Ser Glu Ala Gly Leu His 
1825                1830                1835                1840
Glu Met Asp Ile Arg Tyr Asp Asn Met His Ile Pro Gly Ser Pro Leu 
                1845                1850                1855    
Gln Phe Tyr Val Asp Tyr Val Asn Cys Gly His Val Thr Ala Tyr Gly 
            1860                1865                1870        
Pro Gly Leu Thr His Gly Val Val Asn Lys Pro Ala Thr Phe Thr Val 
        1875                1880                1885            
Asn Thr Lys Asp Ala Gly Glu Gly Gly Leu Ser Leu Ala Ile Glu Gly 
    1890                1895                1900                
Pro Ser Lys Ala Glu Ile Ser Cys Thr Asp Asn Gln Asp Gly Thr Cys 
1905                1910                1915                1920
Ser Val Ser Tyr Leu Pro Val Leu Pro Gly Asp Tyr Ser Ile Leu Val 
                1925                1930                1935    
Lys Tyr Asn Glu Gln His Val Pro Gly Ser Pro Phe Thr Ala Arg Val 
            1940                1945                1950        
Thr Gly Asp Asp Ser Met Arg Met Ser His Leu Lys Val Gly Ser Ala 
        1955                1960                1965            
Ala Asp Ile Pro Ile Asn Ile Ser Glu Thr Asp Leu Ser Leu Leu Thr 
    1970                1975                1980                
Ala Thr Val Val Pro Pro Ser Gly Arg Glu Glu Pro Cys Leu Leu Lys 
1985                1990                1995                2000
Arg Leu Arg Asn Gly His Val Gly Ile Ser Phe Val Pro Lys Glu Thr 
                2005                2010                2015    
Gly Glu His Leu Val His Val Lys Lys Asn Gly Gln His Val Ala Ser 
            2020                2025                2030        
Ser Pro Ile Pro Val Val Ile Ser Gln Ser Glu Ile Gly Asp Ala Ser 
        2035                2040                2045            
Arg Val Arg Val Ser Gly Gln Gly Leu His Glu Gly His Thr Phe Glu 
    2050                2055                2060                
Pro Ala Glu Phe Ile Ile Asp Thr Arg Asp Ala Gly Tyr Gly Gly Leu 
2065                2070                2075                2080
Ser Leu Ser Ile Glu Gly Pro Ser Lys Val Asp Ile Asn Thr Glu Asp 
                2085                2090                2095    
Leu Glu Asp Gly Thr Cys Arg Val Thr Tyr Cys Pro Thr Glu Pro Gly 
            2100                2105                2110        
Asn Tyr Ile Ile Asn Ile Lys Phe Ala Asp Gln His Val Pro Gly Ser 
        2115                2120                2125            
Pro Phe Ser Val Lys Val Thr Gly Glu Gly Arg Val Lys Glu Ser Ile 
    2130                2135                2140                
Thr Arg Arg Arg Arg Ala Pro Ser Val Ala Asn Val Gly Ser His Cys 
2145                2150                2155                2160
Asp Leu Ser Leu Lys Ile Pro Glu Ile Ser Ile Gln Asp Met Thr Ala 
                2165                2170                2175    
Gln Val Thr Ser Pro Ser Gly Lys Thr His Glu Ala Glu Ile Val Glu 
            2180                2185                2190        
Gly Glu Asn His Thr Tyr Cys Ile Arg Phe Val Pro Ala Glu Met Gly 
        2195                2200                2205            
Thr His Thr Val Ser Val Lys Tyr Lys Gly Gln His Val Pro Gly Ser 
    2210                2215                2220                
Pro Phe Gln Phe Thr Val Gly Pro Leu Gly Glu Gly Gly Ala His Lys 
2225                2230                2235                2240
Val Arg Ala Gly Gly Pro Gly Leu Glu Arg Ala Glu Ala Gly Val Pro 
                2245                2250                2255    
Ala Glu Phe Ser Ile Trp Thr Arg Glu Ala Gly Ala Gly Gly Leu Ala 
            2260                2265                2270        
Ile Ala Val Glu Gly Pro Ser Lys Ala Glu Ile Ser Phe Glu Asp Arg 
        2275                2280                2285            
Lys Asp Gly Ser Cys Gly Val Ala Tyr Val Val Gln Glu Pro Gly Asp 
    2290                2295                2300                
Tyr Glu Val Ser Val Lys Phe Asn Glu Glu His Ile Pro Asp Ser Pro 
2305                2310                2315                2320
Phe Val Val Pro Val Ala Ser Pro Ser Gly Asp Ala Arg Arg Leu Thr 
                2325                2330                2335    
Val Ser Ser Leu Gln Glu Ser Gly Leu Lys Val Asn Gln Pro Ala Ser 
            2340                2345                2350        
Phe Ala Val Ser Leu Asn Gly Ala Lys Gly Ala Ile Asp Ala Lys Val 
        2355                2360                2365            
His Ser Pro Ser Gly Ala Leu Glu Glu Cys Tyr Val Thr Glu Ile Asp 
    2370                2375                2380                
Gln Asp Lys Tyr Ala Val Arg Phe Ile Pro Arg Glu Asn Gly Val Tyr 
2385                2390                2395                2400
Leu Ile Asp Val Lys Phe Asn Gly Thr His Ile Pro Gly Ser Pro Phe 
                2405                2410                2415    
Lys Ile Arg Val Gly Glu Pro Gly His Gly Gly Asp Pro Gly Leu Val 
            2420                2425                2430        
Ser Ala Tyr Gly Ala Gly Leu Glu Gly Gly Val Thr Gly Asn Pro Ala 
        2435                2440                2445            
Glu Phe Val Val Asn Thr Ser Asn Ala Gly Ala Gly Ala Leu Ser Val 
    2450                2455                2460                
Thr Ile Asp Gly Pro Ser Lys Val Lys Met Asp Cys Gln Glu Cys Pro 
2465                2470                2475                2480
Glu Gly Tyr Arg Val Thr Tyr Thr Pro Met Ala Pro Gly Ser Tyr Leu 
                2485                2490                2495    
Ile Ser Ile Lys Tyr Gly Gly Pro Tyr His Ile Gly Gly Ser Pro Phe 
            2500                2505                2510        
Lys Ala Lys Val Thr Gly Pro Arg Leu Val Ser Asn His Ser Leu His 
        2515                2520                2525            
Glu Thr Ser Ser Val Phe Val Asp Ser Leu Thr Lys Ala Thr Cys Ala 
    2530                2535                2540                
Pro Gln His Gly Ala Pro Gly Pro Gly Pro Ala Asp Ala Ser Lys Val 
2545                2550                2555                2560
Val Ala Lys Gly Leu Gly Leu Ser Lys Ala Tyr Val Gly Gln Lys Ser 
                2565                2570                2575    
Ser Phe Thr Val Asp Cys Ser Lys Ala Gly Asn Asn Met Leu Leu Val 
            2580                2585                2590        
Gly Val His Gly Pro Arg Thr Pro Cys Glu Glu Ile Leu Val Lys His 
        2595                2600                2605            
Val Gly Ser Arg Leu Tyr Ser Val Ser Tyr Leu Leu Lys Asp Lys Gly 
    2610                2615                2620                
Glu Tyr Thr Leu Val Val Lys Trp Gly Asp Glu His Ile Pro Gly Ser 
2625                2630                2635                2640
Pro Tyr Arg Val Val Val Pro 
                2645        

<210> 29
<211> 2633
<212> PRT
<213> Homo sapiens


<220> 
<223> Filamin B isoform 1 unmodified

<400> 29
Met Pro Val Thr Glu Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys 
1               5                   10                  15      
Ile Gln Gln Asn Thr Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys 
            20                  25                  30          
Val Asn Lys Arg Ile Gly Asn Leu Gln Thr Asp Leu Ser Asp Gly Leu 
        35                  40                  45              
Arg Leu Ile Ala Leu Leu Glu Val Leu Ser Gln Lys Arg Met Tyr Arg 
    50                  55                  60                  
Lys Tyr His Gln Arg Pro Thr Phe Arg Gln Met Gln Leu Glu Asn Val 
65                  70                  75                  80  
Ser Val Ala Leu Glu Phe Leu Asp Arg Glu Ser Ile Lys Leu Val Ser 
                85                  90                  95      
Ile Asp Ser Lys Ala Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly 
            100                 105                 110         
Leu Val Trp Thr Leu Ile Leu His Tyr Ser Ile Ser Met Pro Val Trp 
        115                 120                 125             
Glu Asp Glu Gly Asp Asp Asp Ala Lys Lys Gln Thr Pro Lys Gln Arg 
    130                 135                 140                 
Leu Leu Gly Trp Ile Gln Asn Lys Ile Pro Tyr Leu Pro Ile Thr Asn 
145                 150                 155                 160 
Phe Asn Gln Asn Trp Gln Asp Gly Lys Ala Leu Gly Ala Leu Val Asp 
                165                 170                 175     
Ser Cys Ala Pro Gly Leu Cys Pro Asp Trp Glu Ser Trp Asp Pro Gln 
            180                 185                 190         
Lys Pro Val Asp Asn Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp 
        195                 200                 205             
Leu Gly Val Pro Gln Val Ile Thr Pro Glu Glu Ile Ile His Pro Asp 
    210                 215                 220                 
Val Asp Glu His Ser Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala 
225                 230                 235                 240 
Lys Leu Lys Pro Gly Ala Pro Leu Lys Pro Lys Leu Asn Pro Lys Lys 
                245                 250                 255     
Ala Arg Ala Tyr Gly Arg Gly Ile Glu Pro Thr Gly Asn Met Val Lys 
            260                 265                 270         
Gln Pro Ala Lys Phe Thr Val Asp Thr Ile Ser Ala Gly Gln Gly Asp 
        275                 280                 285             
Val Met Val Phe Val Glu Asp Pro Glu Gly Asn Lys Glu Glu Ala Gln 
    290                 295                 300                 
Val Thr Pro Asp Ser Asp Lys Asn Lys Thr Tyr Ser Val Glu Tyr Leu 
305                 310                 315                 320 
Pro Lys Val Thr Gly Leu His Lys Val Thr Val Leu Phe Ala Gly Gln 
                325                 330                 335     
His Ile Ser Lys Ser Pro Phe Glu Val Ser Val Asp Lys Ala Gln Gly 
            340                 345                 350         
Asp Ala Ser Lys Val Thr Ala Lys Gly Pro Gly Leu Glu Ala Val Gly 
        355                 360                 365             
Asn Ile Ala Asn Lys Pro Thr Tyr Phe Asp Ile Tyr Thr Ala Gly Ala 
    370                 375                 380                 
Gly Val Gly Asp Ile Gly Val Glu Val Glu Asp Pro Gln Gly Lys Asn 
385                 390                 395                 400 
Thr Val Glu Leu Leu Val Glu Asp Lys Gly Asn Gln Val Tyr Arg Cys 
                405                 410                 415     
Val Tyr Lys Pro Met Gln Pro Gly Pro His Val Val Lys Ile Phe Phe 
            420                 425                 430         
Ala Gly Asp Thr Ile Pro Lys Ser Pro Phe Val Val Gln Val Gly Glu 
        435                 440                 445             
Ala Cys Asn Pro Asn Ala Cys Arg Ala Ser Gly Arg Gly Leu Gln Pro 
    450                 455                 460                 
Lys Gly Val Arg Ile Arg Glu Thr Thr Asp Phe Lys Val Asp Thr Lys 
465                 470                 475                 480 
Ala Ala Gly Ser Gly Glu Leu Gly Val Thr Met Lys Gly Pro Lys Gly 
                485                 490                 495     
Leu Glu Glu Leu Val Lys Gln Lys Asp Phe Leu Asp Gly Val Tyr Ala 
            500                 505                 510         
Phe Glu Tyr Tyr Pro Ser Thr Pro Gly Arg Tyr Ser Ile Ala Ile Thr 
        515                 520                 525             
Trp Gly Gly His His Ile Pro Lys Ser Pro Phe Glu Val Gln Val Gly 
    530                 535                 540                 
Pro Glu Ala Gly Met Gln Lys Val Arg Ala Trp Gly Pro Gly Leu His 
545                 550                 555                 560 
Gly Gly Ile Val Gly Arg Ser Ala Asp Phe Val Val Glu Ser Ile Gly 
                565                 570                 575     
Ser Glu Val Gly Ser Leu Gly Phe Ala Ile Glu Gly Pro Ser Gln Ala 
            580                 585                 590         
Lys Ile Glu Tyr Asn Asp Gln Asn Asp Gly Ser Cys Asp Val Lys Tyr 
        595                 600                 605             
Trp Pro Lys Glu Pro Gly Glu Tyr Ala Val His Ile Met Cys Asp Asp 
    610                 615                 620                 
Glu Asp Ile Lys Asp Ser Pro Tyr Met Ala Phe Ile His Pro Ala Thr 
625                 630                 635                 640 
Gly Gly Tyr Asn Pro Asp Leu Val Arg Ala Tyr Gly Pro Gly Leu Glu 
                645                 650                 655     
Lys Ser Gly Cys Ile Val Asn Asn Leu Ala Glu Phe Thr Val Asp Pro 
            660                 665                 670         
Lys Asp Ala Gly Lys Ala Pro Leu Lys Ile Phe Ala Gln Asp Gly Glu 
        675                 680                 685             
Gly Gln Arg Ile Asp Ile Gln Met Lys Asn Arg Met Asp Gly Thr Tyr 
    690                 695                 700                 
Ala Cys Ser Tyr Thr Pro Val Lys Ala Ile Lys His Thr Ile Ala Val 
705                 710                 715                 720 
Val Trp Gly Gly Val Asn Ile Pro His Ser Pro Tyr Arg Val Asn Ile 
                725                 730                 735     
Gly Gln Gly Ser His Pro Gln Lys Val Lys Val Phe Gly Pro Gly Val 
            740                 745                 750         
Glu Arg Ser Gly Leu Lys Ala Asn Glu Pro Thr His Phe Thr Val Asp 
        755                 760                 765             
Cys Thr Glu Ala Gly Glu Gly Asp Val Ser Val Gly Ile Lys Cys Asp 
    770                 775                 780                 
Ala Arg Val Leu Ser Glu Asp Glu Glu Asp Val Asp Phe Asp Ile Ile 
785                 790                 795                 800 
His Asn Ala Asn Asp Thr Phe Thr Val Lys Tyr Val Pro Pro Ala Ala 
                805                 810                 815     
Gly Arg Tyr Thr Ile Lys Val Leu Phe Ala Ser Gln Glu Ile Pro Ala 
            820                 825                 830         
Ser Pro Phe Arg Val Lys Val Asp Pro Ser His Asp Ala Ser Lys Val 
        835                 840                 845             
Lys Ala Glu Gly Pro Gly Leu Ser Lys Ala Gly Val Glu Asn Gly Lys 
    850                 855                 860                 
Pro Thr His Phe Thr Val Tyr Thr Lys Gly Ala Gly Lys Ala Pro Leu 
865                 870                 875                 880 
Asn Val Gln Phe Asn Ser Pro Leu Pro Gly Asp Ala Val Lys Asp Leu 
                885                 890                 895     
Asp Ile Ile Asp Asn Tyr Asp Tyr Ser His Thr Val Lys Tyr Thr Pro 
            900                 905                 910         
Thr Gln Gln Gly Asn Met Gln Val Leu Val Thr Tyr Gly Gly Asp Pro 
        915                 920                 925             
Ile Pro Lys Ser Pro Phe Thr Val Gly Val Ala Ala Pro Leu Asp Leu 
    930                 935                 940                 
Ser Lys Ile Lys Leu Asn Gly Leu Glu Asn Arg Val Glu Val Gly Lys 
945                 950                 955                 960 
Asp Gln Glu Phe Thr Val Asp Thr Arg Gly Ala Gly Gly Gln Gly Lys 
                965                 970                 975     
Leu Asp Val Thr Ile Leu Ser Pro Ser Arg Lys Val Val Pro Cys Leu 
            980                 985                 990         
Val Thr Pro Val Thr Gly Arg Glu Asn Ser Thr Ala Lys Phe Ile Pro 
        995                 1000                1005            
Arg Glu Glu Gly Leu Tyr Ala Val Asp Val Thr Tyr Asp Gly His Pro 
    1010                1015                1020                
Val Pro Gly Ser Pro Tyr Thr Val Glu Ala Ser Leu Pro Pro Asp Pro 
1025                1030                1035                1040
Ser Lys Val Lys Ala His Gly Pro Gly Leu Glu Gly Gly Leu Val Gly 
                1045                1050                1055    
Lys Pro Ala Glu Phe Thr Ile Asp Thr Lys Gly Ala Gly Thr Gly Gly 
            1060                1065                1070        
Leu Gly Leu Thr Val Glu Gly Pro Cys Glu Ala Lys Ile Glu Cys Ser 
        1075                1080                1085            
Asp Asn Gly Asp Gly Thr Cys Ser Val Ser Tyr Leu Pro Thr Lys Pro 
    1090                1095                1100                
Gly Glu Tyr Phe Val Asn Ile Leu Phe Glu Glu Val His Ile Pro Gly 
1105                1110                1115                1120
Ser Pro Phe Lys Ala Asp Ile Glu Met Pro Phe Asp Pro Ser Lys Val 
                1125                1130                1135    
Val Ala Ser Gly Pro Gly Leu Glu His Gly Lys Val Gly Glu Ala Gly 
            1140                1145                1150        
Leu Leu Ser Val Asp Cys Ser Glu Ala Gly Pro Gly Ala Leu Gly Leu 
        1155                1160                1165            
Glu Ala Val Ser Asp Ser Gly Thr Lys Ala Glu Val Ser Ile Gln Asn 
    1170                1175                1180                
Asn Lys Asp Gly Thr Tyr Ala Val Thr Tyr Val Pro Leu Thr Ala Gly 
1185                1190                1195                1200
Met Tyr Thr Leu Thr Met Lys Tyr Gly Gly Glu Leu Val Pro His Phe 
                1205                1210                1215    
Pro Ala Arg Val Lys Val Glu Pro Ala Val Asp Thr Ser Arg Ile Lys 
            1220                1225                1230        
Val Phe Gly Pro Gly Ile Glu Gly Lys Asp Val Phe Arg Glu Ala Thr 
        1235                1240                1245            
Thr Asp Phe Thr Val Asp Ser Arg Pro Leu Thr Gln Val Gly Gly Asp 
    1250                1255                1260                
His Ile Lys Ala His Ile Ala Asn Pro Ser Gly Ala Ser Thr Glu Cys 
1265                1270                1275                1280
Phe Val Thr Asp Asn Ala Asp Gly Thr Tyr Gln Val Glu Tyr Thr Pro 
                1285                1290                1295    
Phe Glu Lys Gly Leu His Val Val Glu Val Thr Tyr Asp Asp Val Pro 
            1300                1305                1310        
Ile Pro Asn Ser Pro Phe Lys Val Ala Val Thr Glu Gly Cys Gln Pro 
        1315                1320                1325            
Ser Arg Val Gln Ala Gln Gly Pro Gly Leu Lys Glu Ala Phe Thr Asn 
    1330                1335                1340                
Lys Pro Asn Val Phe Thr Val Val Thr Arg Gly Ala Gly Ile Gly Gly 
1345                1350                1355                1360
Leu Gly Ile Thr Val Glu Gly Pro Ser Glu Ser Lys Ile Asn Cys Arg 
                1365                1370                1375    
Asp Asn Lys Asp Gly Ser Cys Ser Ala Glu Tyr Ile Pro Phe Ala Pro 
            1380                1385                1390        
Gly Asp Tyr Asp Val Asn Ile Thr Tyr Gly Gly Ala His Ile Pro Gly 
        1395                1400                1405            
Ser Pro Phe Arg Val Pro Val Lys Asp Val Val Asp Pro Ser Lys Val 
    1410                1415                1420                
Lys Ile Ala Gly Pro Gly Leu Gly Ser Gly Val Arg Ala Arg Val Leu 
1425                1430                1435                1440
Gln Ser Phe Thr Val Asp Ser Ser Lys Ala Gly Leu Ala Pro Leu Glu 
                1445                1450                1455    
Val Arg Val Leu Gly Pro Arg Ala Asp Asp Thr Asp Ser Gln Ser Trp 
            1460                1465                1470        
Arg Ser Pro Leu Lys Ala Leu Ser Glu Phe Phe Lys Gly Asp Pro Lys 
        1475                1480                1485            
Gly Asp Phe Asn Lys Thr Gly Leu Val Glu Pro Val Asn Val Val Asp 
    1490                1495                1500                
Asn Gly Asp Gly Thr His Thr Val Thr Tyr Thr Pro Ser Gln Glu Gly 
1505                1510                1515                1520
Pro Tyr Met Val Ser Val Lys Tyr Ala Asp Glu Glu Ile Pro Arg Ser 
                1525                1530                1535    
Pro Phe Lys Val Lys Val Leu Pro Thr Tyr Asp Ala Ser Lys Val Thr 
            1540                1545                1550        
Ala Ser Gly Pro Gly Leu Ser Ser Tyr Gly Val Pro Ala Ser Leu Pro 
        1555                1560                1565            
Val Asp Phe Ala Ile Asp Ala Arg Asp Ala Gly Glu Gly Leu Leu Ala 
    1570                1575                1580                
Val Gln Ile Thr Asp Gln Glu Gly Lys Pro Lys Arg Ala Ile Val His 
1585                1590                1595                1600
Asp Asn Lys Asp Gly Thr Tyr Ala Val Thr Tyr Ile Pro Asp Lys Thr 
                1605                1610                1615    
Gly Arg Tyr Met Ile Gly Val Thr Tyr Gly Gly Asp Asp Ile Pro Leu 
            1620                1625                1630        
Ser Pro Tyr Arg Ile Arg Ala Thr Gln Thr Gly Asp Ala Ser Lys Cys 
        1635                1640                1645            
Leu Ala Thr Gly Pro Gly Ile Ala Ser Thr Val Lys Thr Gly Glu Glu 
    1650                1655                1660                
Val Gly Phe Val Val Asp Ala Lys Thr Ala Gly Lys Gly Lys Val Thr 
1665                1670                1675                1680
Cys Thr Val Leu Thr Pro Asp Gly Thr Glu Ala Glu Ala Asp Val Ile 
                1685                1690                1695    
Glu Asn Glu Asp Gly Thr Tyr Asp Ile Phe Tyr Thr Ala Ala Lys Pro 
            1700                1705                1710        
Gly Thr Tyr Val Ile Tyr Val Arg Phe Gly Gly Val Asp Ile Pro Asn 
        1715                1720                1725            
Ser Pro Phe Thr Val Met Ala Thr Asp Gly Glu Val Thr Ala Val Glu 
    1730                1735                1740                
Glu Ala Pro Val Asn Ala Cys Pro Pro Gly Phe Arg Pro Trp Val Thr 
1745                1750                1755                1760
Glu Glu Ala Tyr Val Pro Val Ser Asp Met Asn Gly Leu Gly Phe Lys 
                1765                1770                1775    
Pro Phe Asp Leu Val Ile Pro Phe Ala Val Arg Lys Gly Glu Ile Thr 
            1780                1785                1790        
Gly Glu Val His Met Pro Ser Gly Lys Thr Ala Thr Pro Glu Ile Val 
        1795                1800                1805            
Asp Asn Lys Asp Gly Thr Val Thr Val Arg Tyr Ala Pro Thr Glu Val 
    1810                1815                1820                
Gly Leu His Glu Met His Ile Lys Tyr Met Gly Ser His Ile Pro Glu 
1825                1830                1835                1840
Ser Pro Leu Gln Phe Tyr Val Asn Tyr Pro Asn Ser Gly Ser Val Ser 
                1845                1850                1855    
Ala Tyr Gly Pro Gly Leu Val Tyr Gly Val Ala Asn Lys Thr Ala Thr 
            1860                1865                1870        
Phe Thr Ile Val Thr Glu Asp Ala Gly Glu Gly Gly Leu Asp Leu Ala 
        1875                1880                1885            
Ile Glu Gly Pro Ser Lys Ala Glu Ile Ser Cys Ile Asp Asn Lys Asp 
    1890                1895                1900                
Gly Thr Cys Thr Val Thr Tyr Leu Pro Thr Leu Pro Gly Asp Tyr Ser 
1905                1910                1915                1920
Ile Leu Val Lys Tyr Asn Asp Lys His Ile Pro Gly Ser Pro Phe Thr 
                1925                1930                1935    
Ala Lys Ile Thr Asp Asp Ser Arg Arg Cys Ser Gln Val Lys Leu Gly 
            1940                1945                1950        
Ser Ala Ala Asp Phe Leu Leu Asp Ile Ser Glu Thr Asp Leu Ser Ser 
        1955                1960                1965            
Leu Thr Ala Ser Ile Lys Ala Pro Ser Gly Arg Asp Glu Pro Cys Leu 
    1970                1975                1980                
Leu Lys Arg Leu Pro Asn Asn His Ile Gly Ile Ser Phe Ile Pro Arg 
1985                1990                1995                2000
Glu Val Gly Glu His Leu Val Ser Ile Lys Lys Asn Gly Asn His Val 
                2005                2010                2015    
Ala Asn Ser Pro Val Ser Ile Met Val Val Gln Ser Glu Ile Gly Asp 
            2020                2025                2030        
Ala Arg Arg Ala Lys Val Tyr Gly Arg Gly Leu Ser Glu Gly Arg Thr 
        2035                2040                2045            
Phe Glu Met Ser Asp Phe Ile Val Asp Thr Arg Asp Ala Gly Tyr Gly 
    2050                2055                2060                
Gly Ile Ser Leu Ala Val Glu Gly Pro Ser Lys Val Asp Ile Gln Thr 
2065                2070                2075                2080
Glu Asp Leu Glu Asp Gly Thr Cys Lys Val Ser Tyr Phe Pro Thr Val 
                2085                2090                2095    
Pro Gly Val Tyr Ile Val Ser Thr Lys Phe Ala Asp Glu His Val Pro 
            2100                2105                2110        
Gly Ser Pro Phe Thr Val Lys Ile Ser Gly Glu Gly Arg Val Lys Glu 
        2115                2120                2125            
Ser Ile Thr Arg Thr Ser Arg Ala Pro Ser Val Ala Thr Val Gly Ser 
    2130                2135                2140                
Ile Cys Asp Leu Asn Leu Lys Ile Pro Glu Ile Asn Ser Ser Asp Met 
2145                2150                2155                2160
Ser Ala His Val Thr Ser Pro Ser Gly Arg Val Thr Glu Ala Glu Ile 
                2165                2170                2175    
Val Pro Met Gly Lys Asn Ser His Cys Val Arg Phe Val Pro Gln Glu 
            2180                2185                2190        
Met Gly Val His Thr Val Ser Val Lys Tyr Arg Gly Gln His Val Thr 
        2195                2200                2205            
Gly Ser Pro Phe Gln Phe Thr Val Gly Pro Leu Gly Glu Gly Gly Ala 
    2210                2215                2220                
His Lys Val Arg Ala Gly Gly Pro Gly Leu Glu Arg Gly Glu Ala Gly 
2225                2230                2235                2240
Val Pro Ala Glu Phe Ser Ile Trp Thr Arg Glu Ala Gly Ala Gly Gly 
                2245                2250                2255    
Leu Ser Ile Ala Val Glu Gly Pro Ser Lys Ala Glu Ile Thr Phe Asp 
            2260                2265                2270        
Asp His Lys Asn Gly Ser Cys Gly Val Ser Tyr Ile Ala Gln Glu Pro 
        2275                2280                2285            
Gly Asn Tyr Glu Val Ser Ile Lys Phe Asn Asp Glu His Ile Pro Glu 
    2290                2295                2300                
Ser Pro Tyr Leu Val Pro Val Ile Ala Pro Ser Asp Asp Ala Arg Arg 
2305                2310                2315                2320
Leu Thr Val Met Ser Leu Gln Glu Ser Gly Leu Lys Val Asn Gln Pro 
                2325                2330                2335    
Ala Ser Phe Ala Ile Arg Leu Asn Gly Ala Lys Gly Lys Ile Asp Ala 
            2340                2345                2350        
Lys Val His Ser Pro Ser Gly Ala Val Glu Glu Cys His Val Ser Glu 
        2355                2360                2365            
Leu Glu Pro Asp Lys Tyr Ala Val Arg Phe Ile Pro His Glu Asn Gly 
    2370                2375                2380                
Val His Thr Ile Asp Val Lys Phe Asn Gly Ser His Val Val Gly Ser 
2385                2390                2395                2400
Pro Phe Lys Val Arg Val Gly Glu Pro Gly Gln Ala Gly Asn Pro Ala 
                2405                2410                2415    
Leu Val Ser Ala Tyr Gly Thr Gly Leu Glu Gly Gly Thr Thr Gly Ile 
            2420                2425                2430        
Gln Ser Glu Phe Phe Ile Asn Thr Thr Arg Ala Gly Pro Gly Thr Leu 
        2435                2440                2445            
Ser Val Thr Ile Glu Gly Pro Ser Lys Val Lys Met Asp Cys Gln Glu 
    2450                2455                2460                
Thr Pro Glu Gly Tyr Lys Val Met Tyr Thr Pro Met Ala Pro Gly Asn 
2465                2470                2475                2480
Tyr Leu Ile Ser Val Lys Tyr Gly Gly Pro Asn His Ile Val Gly Ser 
                2485                2490                2495    
Pro Phe Lys Ala Lys Val Thr Gly Gln Arg Leu Val Ser Pro Gly Ser 
            2500                2505                2510        
Ala Asn Glu Thr Ser Ser Ile Leu Val Glu Ser Val Thr Arg Ser Ser 
        2515                2520                2525            
Thr Glu Thr Cys Tyr Ser Ala Ile Pro Lys Ala Ser Ser Asp Ala Ser 
    2530                2535                2540                
Lys Val Thr Ser Lys Gly Ala Gly Leu Ser Lys Ala Phe Val Gly Gln 
2545                2550                2555                2560
Lys Ser Ser Phe Leu Val Asp Cys Ser Lys Ala Gly Ser Asn Met Leu 
                2565                2570                2575    
Leu Ile Gly Val His Gly Pro Thr Thr Pro Cys Glu Glu Val Ser Met 
            2580                2585                2590        
Lys His Val Gly Asn Gln Gln Tyr Asn Val Thr Tyr Val Val Lys Glu 
        2595                2600                2605            
Arg Gly Asp Tyr Val Leu Ala Val Lys Trp Gly Glu Glu His Ile Pro 
    2610                2615                2620                
Gly Ser Pro Phe His Val Thr Val Pro 
2625                2630            

<210> 30
<211> 421
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 30
Met Asp Ala Gln Thr Arg Arg Arg Glu Arg Arg Ala Glu Lys Gln Ala 
1               5                   10                  15      
Gln Trp Lys Ala Ala Asn Pro Leu Leu Val Gly Val Ser Ala Lys Pro 
            20                  25                  30          
Val Asn Arg Pro Ile Leu Ser Gly Thr Asp Val Lys Asp Ala Lys Val 
        35                  40                  45              
Ile Ser Val Ser Thr Gly Thr Lys Cys Ile Asn Gly Glu Tyr Met Ser 
    50                  55                  60                  
Asp Arg Gly Leu Ala Leu Asn Asp Cys His Ala Glu Ile Ile Ser Arg 
65                  70                  75                  80  
Arg Ser Leu Leu Arg Phe Leu Tyr Thr Gln Leu Glu Leu Tyr Leu Asn 
                85                  90                  95      
Asn Lys Asp Asp Gln Lys Arg Ser Ile Phe Gln Lys Ser Glu Arg Gly 
            100                 105                 110         
Gly Phe Arg Leu Lys Glu Asn Val Gln Phe His Leu Tyr Ile Ser Thr 
        115                 120                 125             
Ser Pro Cys Gly Asp Ala Arg Ile Phe Ser Pro His Glu Pro Ile Leu 
    130                 135                 140                 
Glu Gly Ser Arg Ser Tyr Thr Gln Ala Gly Val Gln Trp Cys Asn His 
145                 150                 155                 160 
Gly Ser Leu Gln Pro Arg Pro Pro Gly Leu Leu Ser Asp Pro Ser Thr 
                165                 170                 175     
Ser Thr Phe Gln Gly Ala Gly Thr Thr Glu Pro Ala Asp Arg His Pro 
            180                 185                 190         
Asn Arg Lys Ala Arg Gly Gln Leu Arg Thr Lys Ile Glu Ser Gly Glu 
        195                 200                 205             
Gly Thr Ile Pro Val Arg Ser Asn Ala Ser Ile Gln Thr Trp Asp Gly 
    210                 215                 220                 
Val Leu Gln Gly Glu Arg Leu Leu Thr Met Ser Cys Ser Asp Lys Ile 
225                 230                 235                 240 
Ala Arg Trp Asn Val Val Gly Ile Gln Gly Ser Leu Leu Ser Ile Phe 
                245                 250                 255     
Val Glu Pro Ile Tyr Phe Ser Ser Ile Ile Leu Gly Ser Leu Tyr His 
            260                 265                 270         
Gly Asp His Leu Ser Arg Ala Met Tyr Gln Arg Ile Ser Asn Ile Glu 
        275                 280                 285             
Asp Leu Pro Pro Leu Tyr Thr Leu Asn Lys Pro Leu Leu Ser Gly Ile 
    290                 295                 300                 
Ser Asn Ala Glu Ala Arg Gln Pro Gly Lys Ala Pro Asn Phe Ser Val 
305                 310                 315                 320 
Asn Trp Thr Val Gly Asp Ser Ala Ile Glu Val Ile Asn Ala Thr Thr 
                325                 330                 335     
Gly Lys Asp Glu Leu Gly Arg Ala Ser Arg Leu Cys Lys His Ala Leu 
            340                 345                 350         
Tyr Cys Arg Trp Met Arg Val His Gly Lys Val Pro Ser His Leu Leu 
        355                 360                 365             
Arg Ser Lys Ile Thr Lys Pro Asn Val Tyr His Glu Ser Lys Leu Ala 
    370                 375                 380                 
Ala Lys Glu Tyr Gln Ala Ala Lys Ala Arg Leu Phe Thr Ala Phe Ile 
385                 390                 395                 400 
Lys Ala Gly Leu Gly Ala Trp Val Glu Lys Pro Thr Glu Gln Asp Gln 
                405                 410                 415     
Phe Ser Leu Thr Pro 
            420     

<210> 31
<211> 401
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 31
Met Asp Ala Gln Thr Arg Arg Arg Glu Arg Arg Ala Glu Lys Gln Ala 
1               5                   10                  15      
Gln Trp Lys Ala Ala Asn Pro Leu Leu Val Gly Val Ser Ala Lys Pro 
            20                  25                  30          
Val Asn Arg Pro Ile Leu Ser Gly Arg Lys Ile Leu Ala Ala Ile Ile 
        35                  40                  45              
Met Lys Lys Asp Ser Glu Asp Met Gly Val Val Val Ser Leu Gly Thr 
    50                  55                  60                  
Gly Asn Arg Cys Val Lys Gly Asp Ser Leu Ser Leu Lys Gly Glu Thr 
65                  70                  75                  80  
Val Asn Asp Cys His Ala Glu Ile Ile Ser Arg Arg Gly Phe Ile Arg 
                85                  90                  95      
Phe Leu Tyr Ser Glu Leu Met Lys Tyr Asn Ser Gln Thr Ala Lys Asp 
            100                 105                 110         
Ser Ile Phe Glu Pro Ala Lys Gly Gly Glu Lys Leu Gln Ile Lys Lys 
        115                 120                 125             
Thr Val Ser Phe His Leu Tyr Ile Ser Thr Ala Pro Cys Gly Asp Gly 
    130                 135                 140                 
Ala Leu Phe Asp Lys Ser Cys Ser Asp Arg Ala Met Glu Ser Thr Glu 
145                 150                 155                 160 
Ser Arg His Tyr Pro Val Phe Glu Asn Pro Lys Gln Gly Lys Leu Arg 
                165                 170                 175     
Thr Lys Val Glu Asn Gly Glu Gly Thr Ile Pro Val Glu Ser Ser Asp 
            180                 185                 190         
Ile Val Pro Thr Trp Asp Gly Ile Arg Leu Gly Glu Arg Leu Arg Thr 
        195                 200                 205             
Met Ser Cys Ser Asp Lys Ile Leu Arg Trp Asn Val Leu Gly Leu Gln 
    210                 215                 220                 
Gly Ala Leu Leu Thr His Phe Leu Gln Pro Ile Tyr Leu Lys Ser Val 
225                 230                 235                 240 
Thr Leu Gly Tyr Leu Phe Ser Gln Gly His Leu Thr Arg Ala Ile Cys 
                245                 250                 255     
Cys Arg Val Thr Arg Asp Gly Ser Ala Phe Glu Asp Gly Leu Arg His 
            260                 265                 270         
Pro Phe Ile Val Asn His Pro Lys Val Gly Arg Val Ser Ile Tyr Asp 
        275                 280                 285             
Ser Lys Arg Gln Ser Gly Lys Thr Lys Glu Thr Ser Val Asn Trp Cys 
    290                 295                 300                 
Leu Ala Asp Gly Tyr Asp Leu Glu Ile Leu Asp Gly Thr Arg Gly Thr 
305                 310                 315                 320 
Val Asp Gly Pro Arg Asn Glu Leu Ser Arg Val Ser Lys Lys Asn Ile 
                325                 330                 335     
Phe Leu Leu Phe Lys Lys Leu Cys Ser Phe Arg Tyr Arg Arg Asp Leu 
            340                 345                 350         
Leu Arg Leu Ser Tyr Gly Glu Ala Lys Lys Ala Ala Arg Asp Tyr Glu 
        355                 360                 365             
Thr Ala Lys Asn Tyr Phe Lys Lys Gly Leu Lys Asp Met Gly Tyr Gly 
    370                 375                 380                 
Asn Trp Ile Ser Lys Pro Gln Glu Glu Lys Asn Phe Tyr Leu Cys Pro 
385                 390                 395                 400 
Val 
    

<210> 32
<211> 565
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 32
Met Gly Pro Gly Ser Asp Lys Asp Cys Glu Met Lys Arg Thr Thr Leu 
1               5                   10                  15      
Asp Ser Pro Leu Gly Lys Leu Glu Leu Ser Gly Cys Glu Gln Gly Leu 
            20                  25                  30          
His Glu Ile Ile Phe Leu Gly Lys Gly Thr Ser Ala Ala Asp Ala Val 
        35                  40                  45              
Glu Val Pro Ala Pro Ala Ala Val Leu Gly Gly Pro Glu Pro Leu Met 
    50                  55                  60                  
Gln Ala Thr Ala Trp Leu Asn Ala Tyr Phe His Gln Pro Glu Ala Ile 
65                  70                  75                  80  
Glu Glu Phe Pro Val Pro Ala Leu His His Pro Val Phe Gln Gln Glu 
                85                  90                  95      
Ser Phe Thr Arg Gln Val Leu Trp Lys Leu Leu Lys Val Val Lys Phe 
            100                 105                 110         
Gly Glu Val Ile Ser Tyr Ser His Leu Ala Ala Leu Ala Gly Asn Pro 
        115                 120                 125             
Ala Ala Thr Ala Ala Val Lys Thr Ala Leu Ser Gly Asn Pro Val Pro 
    130                 135                 140                 
Ile Leu Ile Pro Cys His Arg Val Val Gln Gly Asp Leu Asp Val Gly 
145                 150                 155                 160 
Gly Tyr Glu Gly Gly Leu Ala Val Lys Glu Trp Leu Leu Ala His Glu 
                165                 170                 175     
Gly His Arg Leu Gly Lys Arg Gly Thr Asp Val Lys Asp Ala Lys Val 
            180                 185                 190         
Ile Ser Val Ser Thr Gly Thr Lys Cys Ile Asn Gly Glu Tyr Met Ser 
        195                 200                 205             
Asp Arg Gly Leu Ala Leu Asn Asp Cys His Ala Glu Ile Ile Ser Arg 
    210                 215                 220                 
Arg Ser Leu Leu Arg Phe Leu Tyr Thr Gln Leu Glu Leu Tyr Leu Asn 
225                 230                 235                 240 
Asn Lys Asp Asp Gln Lys Arg Ser Ile Phe Gln Lys Ser Glu Arg Gly 
                245                 250                 255     
Gly Phe Arg Leu Lys Glu Asn Val Gln Phe His Leu Tyr Ile Ser Thr 
            260                 265                 270         
Ser Pro Cys Gly Asp Ala Arg Ile Phe Ser Pro His Glu Pro Ile Leu 
        275                 280                 285             
Glu Gly Ser Arg Ser Tyr Thr Gln Ala Gly Val Gln Trp Cys Asn His 
    290                 295                 300                 
Gly Ser Leu Gln Pro Arg Pro Pro Gly Leu Leu Ser Asp Pro Ser Thr 
305                 310                 315                 320 
Ser Thr Phe Gln Gly Ala Gly Thr Thr Glu Pro Ala Asp Arg His Pro 
                325                 330                 335     
Asn Arg Lys Ala Arg Gly Gln Leu Arg Thr Lys Ile Glu Ser Gly Glu 
            340                 345                 350         
Gly Thr Ile Pro Val Arg Ser Asn Ala Ser Ile Gln Thr Trp Asp Gly 
        355                 360                 365             
Val Leu Gln Gly Glu Arg Leu Leu Thr Met Ser Cys Ser Asp Lys Ile 
    370                 375                 380                 
Ala Arg Trp Asn Val Val Gly Ile Gln Gly Ser Leu Leu Ser Ile Phe 
385                 390                 395                 400 
Val Glu Pro Ile Tyr Phe Ser Ser Ile Ile Leu Gly Ser Leu Tyr His 
                405                 410                 415     
Gly Asp His Leu Ser Arg Ala Met Tyr Gln Arg Ile Ser Asn Ile Glu 
            420                 425                 430         
Asp Leu Pro Pro Leu Tyr Thr Leu Asn Lys Pro Leu Leu Ser Gly Ile 
        435                 440                 445             
Ser Asn Ala Glu Ala Arg Gln Pro Gly Lys Ala Pro Asn Phe Ser Val 
    450                 455                 460                 
Asn Trp Thr Val Gly Asp Ser Ala Ile Glu Val Ile Asn Ala Thr Thr 
465                 470                 475                 480 
Gly Lys Asp Glu Leu Gly Arg Ala Ser Arg Leu Cys Lys His Ala Leu 
                485                 490                 495     
Tyr Cys Arg Trp Met Arg Val His Gly Lys Val Pro Ser His Leu Leu 
            500                 505                 510         
Arg Ser Lys Ile Thr Lys Pro Asn Val Tyr His Glu Ser Lys Leu Ala 
        515                 520                 525             
Ala Lys Glu Tyr Gln Ala Ala Lys Ala Arg Leu Phe Thr Ala Phe Ile 
    530                 535                 540                 
Lys Ala Gly Leu Gly Ala Trp Val Glu Lys Pro Thr Glu Gln Asp Gln 
545                 550                 555                 560 
Phe Ser Leu Thr Pro 
                565 

<210> 33
<211> 545
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 33
Met Gly Pro Gly Ser Asp Lys Asp Cys Glu Met Lys Arg Thr Thr Leu 
1               5                   10                  15      
Asp Ser Pro Leu Gly Lys Leu Glu Leu Ser Gly Cys Glu Gln Gly Leu 
            20                  25                  30          
His Glu Ile Ile Phe Leu Gly Lys Gly Thr Ser Ala Ala Asp Ala Val 
        35                  40                  45              
Glu Val Pro Ala Pro Ala Ala Val Leu Gly Gly Pro Glu Pro Leu Met 
    50                  55                  60                  
Gln Ala Thr Ala Trp Leu Asn Ala Tyr Phe His Gln Pro Glu Ala Ile 
65                  70                  75                  80  
Glu Glu Phe Pro Val Pro Ala Leu His His Pro Val Phe Gln Gln Glu 
                85                  90                  95      
Ser Phe Thr Arg Gln Val Leu Trp Lys Leu Leu Lys Val Val Lys Phe 
            100                 105                 110         
Gly Glu Val Ile Ser Tyr Ser His Leu Ala Ala Leu Ala Gly Asn Pro 
        115                 120                 125             
Ala Ala Thr Ala Ala Val Lys Thr Ala Leu Ser Gly Asn Pro Val Pro 
    130                 135                 140                 
Ile Leu Ile Pro Cys His Arg Val Val Gln Gly Asp Leu Asp Val Gly 
145                 150                 155                 160 
Gly Tyr Glu Gly Gly Leu Ala Val Lys Glu Trp Leu Leu Ala His Glu 
                165                 170                 175     
Gly His Arg Leu Gly Lys Arg Gly Arg Lys Ile Leu Ala Ala Ile Ile 
            180                 185                 190         
Met Lys Lys Asp Ser Glu Asp Met Gly Val Val Val Ser Leu Gly Thr 
        195                 200                 205             
Gly Asn Arg Cys Val Lys Gly Asp Ser Leu Ser Leu Lys Gly Glu Thr 
    210                 215                 220                 
Val Asn Asp Cys His Ala Glu Ile Ile Ser Arg Arg Gly Phe Ile Arg 
225                 230                 235                 240 
Phe Leu Tyr Ser Glu Leu Met Lys Tyr Asn Ser Gln Thr Ala Lys Asp 
                245                 250                 255     
Ser Ile Phe Glu Pro Ala Lys Gly Gly Glu Lys Leu Gln Ile Lys Lys 
            260                 265                 270         
Thr Val Ser Phe His Leu Tyr Ile Ser Thr Ala Pro Cys Gly Asp Gly 
        275                 280                 285             
Ala Leu Phe Asp Lys Ser Cys Ser Asp Arg Ala Met Glu Ser Thr Glu 
    290                 295                 300                 
Ser Arg His Tyr Pro Val Phe Glu Asn Pro Lys Gln Gly Lys Leu Arg 
305                 310                 315                 320 
Thr Lys Val Glu Asn Gly Glu Gly Thr Ile Pro Val Glu Ser Ser Asp 
                325                 330                 335     
Ile Val Pro Thr Trp Asp Gly Ile Arg Leu Gly Glu Arg Leu Arg Thr 
            340                 345                 350         
Met Ser Cys Ser Asp Lys Ile Leu Arg Trp Asn Val Leu Gly Leu Gln 
        355                 360                 365             
Gly Ala Leu Leu Thr His Phe Leu Gln Pro Ile Tyr Leu Lys Ser Val 
    370                 375                 380                 
Thr Leu Gly Tyr Leu Phe Ser Gln Gly His Leu Thr Arg Ala Ile Cys 
385                 390                 395                 400 
Cys Arg Val Thr Arg Asp Gly Ser Ala Phe Glu Asp Gly Leu Arg His 
                405                 410                 415     
Pro Phe Ile Val Asn His Pro Lys Val Gly Arg Val Ser Ile Tyr Asp 
            420                 425                 430         
Ser Lys Arg Gln Ser Gly Lys Thr Lys Glu Thr Ser Val Asn Trp Cys 
        435                 440                 445             
Leu Ala Asp Gly Tyr Asp Leu Glu Ile Leu Asp Gly Thr Arg Gly Thr 
    450                 455                 460                 
Val Asp Gly Pro Arg Asn Glu Leu Ser Arg Val Ser Lys Lys Asn Ile 
465                 470                 475                 480 
Phe Leu Leu Phe Lys Lys Leu Cys Ser Phe Arg Tyr Arg Arg Asp Leu 
                485                 490                 495     
Leu Arg Leu Ser Tyr Gly Glu Ala Lys Lys Ala Ala Arg Asp Tyr Glu 
            500                 505                 510         
Thr Ala Lys Asn Tyr Phe Lys Lys Gly Leu Lys Asp Met Gly Tyr Gly 
        515                 520                 525             
Asn Trp Ile Ser Lys Pro Gln Glu Glu Lys Asn Phe Tyr Leu Cys Pro 
    530                 535                 540                 
Val 
545 

<210> 34
<211> 362
<212> PRT
<213> Artificial Sequence


<220> 
<223> ADAR1 catalytic domain

<400> 34
Gly Arg Lys Ile Leu Ala Ala Ile Ile Met Lys Lys Asp Ser Glu Asp 
1               5                   10                  15      
Met Gly Val Val Val Ser Leu Gly Thr Gly Asn Arg Cys Val Lys Gly 
            20                  25                  30          
Asp Ser Leu Ser Leu Lys Gly Glu Thr Val Asn Asp Cys His Ala Glu 
        35                  40                  45              
Ile Ile Ser Arg Arg Gly Phe Ile Arg Phe Leu Tyr Ser Glu Leu Met 
    50                  55                  60                  
Lys Tyr Asn Ser Gln Thr Ala Lys Asp Ser Ile Phe Glu Pro Ala Lys 
65                  70                  75                  80  
Gly Gly Glu Lys Leu Gln Ile Lys Lys Thr Val Ser Phe His Leu Tyr 
                85                  90                  95      
Ile Ser Thr Ala Pro Cys Gly Asp Gly Ala Leu Phe Asp Lys Ser Cys 
            100                 105                 110         
Ser Asp Arg Ala Met Glu Ser Thr Glu Ser Arg His Tyr Pro Val Phe 
        115                 120                 125             
Glu Asn Pro Lys Gln Gly Lys Leu Arg Thr Lys Val Glu Asn Gly Glu 
    130                 135                 140                 
Gly Thr Ile Pro Val Glu Ser Ser Asp Ile Val Pro Thr Trp Asp Gly 
145                 150                 155                 160 
Ile Arg Leu Gly Glu Arg Leu Arg Thr Met Ser Cys Ser Asp Lys Ile 
                165                 170                 175     
Leu Arg Trp Asn Val Leu Gly Leu Gln Gly Ala Leu Leu Thr His Phe 
            180                 185                 190         
Leu Gln Pro Ile Tyr Leu Lys Ser Val Thr Leu Gly Tyr Leu Phe Ser 
        195                 200                 205             
Gln Gly His Leu Thr Arg Ala Ile Cys Cys Arg Val Thr Arg Asp Gly 
    210                 215                 220                 
Ser Ala Phe Glu Asp Gly Leu Arg His Pro Phe Ile Val Asn His Pro 
225                 230                 235                 240 
Lys Val Gly Arg Val Ser Ile Tyr Asp Ser Lys Arg Gln Ser Gly Lys 
                245                 250                 255     
Thr Lys Glu Thr Ser Val Asn Trp Cys Leu Ala Asp Gly Tyr Asp Leu 
            260                 265                 270         
Glu Ile Leu Asp Gly Thr Arg Gly Thr Val Asp Gly Pro Arg Asn Glu 
        275                 280                 285             
Leu Ser Arg Val Ser Lys Lys Asn Ile Phe Leu Leu Phe Lys Lys Leu 
    290                 295                 300                 
Cys Ser Phe Arg Tyr Arg Arg Asp Leu Leu Arg Leu Ser Tyr Gly Glu 
305                 310                 315                 320 
Ala Lys Lys Ala Ala Arg Asp Tyr Glu Thr Ala Lys Asn Tyr Phe Lys 
                325                 330                 335     
Lys Gly Leu Lys Asp Met Gly Tyr Gly Asn Trp Ile Ser Lys Pro Gln 
            340                 345                 350         
Glu Glu Lys Asn Phe Tyr Leu Cys Pro Val 
        355                 360         

<210> 35
<211> 382
<212> PRT
<213> Artificial Sequence


<220> 
<223> ADAR2 catalytic domain

<400> 35
Gly Thr Asp Val Lys Asp Ala Lys Val Ile Ser Val Ser Thr Gly Thr 
1               5                   10                  15      
Lys Cys Ile Asn Gly Glu Tyr Met Ser Asp Arg Gly Leu Ala Leu Asn 
            20                  25                  30          
Asp Cys His Ala Glu Ile Ile Ser Arg Arg Ser Leu Leu Arg Phe Leu 
        35                  40                  45              
Tyr Thr Gln Leu Glu Leu Tyr Leu Asn Asn Lys Asp Asp Gln Lys Arg 
    50                  55                  60                  
Ser Ile Phe Gln Lys Ser Glu Arg Gly Gly Phe Arg Leu Lys Glu Asn 
65                  70                  75                  80  
Val Gln Phe His Leu Tyr Ile Ser Thr Ser Pro Cys Gly Asp Ala Arg 
                85                  90                  95      
Ile Phe Ser Pro His Glu Pro Ile Leu Glu Gly Ser Arg Ser Tyr Thr 
            100                 105                 110         
Gln Ala Gly Val Gln Trp Cys Asn His Gly Ser Leu Gln Pro Arg Pro 
        115                 120                 125             
Pro Gly Leu Leu Ser Asp Pro Ser Thr Ser Thr Phe Gln Gly Ala Gly 
    130                 135                 140                 
Thr Thr Glu Pro Ala Asp Arg His Pro Asn Arg Lys Ala Arg Gly Gln 
145                 150                 155                 160 
Leu Arg Thr Lys Ile Glu Ser Gly Glu Gly Thr Ile Pro Val Arg Ser 
                165                 170                 175     
Asn Ala Ser Ile Gln Thr Trp Asp Gly Val Leu Gln Gly Glu Arg Leu 
            180                 185                 190         
Leu Thr Met Ser Cys Ser Asp Lys Ile Ala Arg Trp Asn Val Val Gly 
        195                 200                 205             
Ile Gln Gly Ser Leu Leu Ser Ile Phe Val Glu Pro Ile Tyr Phe Ser 
    210                 215                 220                 
Ser Ile Ile Leu Gly Ser Leu Tyr His Gly Asp His Leu Ser Arg Ala 
225                 230                 235                 240 
Met Tyr Gln Arg Ile Ser Asn Ile Glu Asp Leu Pro Pro Leu Tyr Thr 
                245                 250                 255     
Leu Asn Lys Pro Leu Leu Ser Gly Ile Ser Asn Ala Glu Ala Arg Gln 
            260                 265                 270         
Pro Gly Lys Ala Pro Asn Phe Ser Val Asn Trp Thr Val Gly Asp Ser 
        275                 280                 285             
Ala Ile Glu Val Ile Asn Ala Thr Thr Gly Lys Asp Glu Leu Gly Arg 
    290                 295                 300                 
Ala Ser Arg Leu Cys Lys His Ala Leu Tyr Cys Arg Trp Met Arg Val 
305                 310                 315                 320 
His Gly Lys Val Pro Ser His Leu Leu Arg Ser Lys Ile Thr Lys Pro 
                325                 330                 335     
Asn Val Tyr His Glu Ser Lys Leu Ala Ala Lys Glu Tyr Gln Ala Ala 
            340                 345                 350         
Lys Ala Arg Leu Phe Thr Ala Phe Ile Lys Ala Gly Leu Gly Ala Trp 
        355                 360                 365             
Val Glu Lys Pro Thr Glu Gln Asp Gln Phe Ser Leu Thr Pro 
    370                 375                 380         

<210> 36
<211> 529
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 36
Met Ser Pro Lys Lys Lys Arg Lys Val Gly Ser Ala Ser Asn Phe Thr 
1               5                   10                  15      
Gln Phe Val Leu Val Asp Asn Gly Gly Thr Gly Asp Val Thr Val Ala 
            20                  25                  30          
Pro Ser Asn Phe Ala Asn Gly Val Ala Glu Trp Ile Ser Ser Asn Ser 
        35                  40                  45              
Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser Val Arg Gln Ser Ser Ala 
    50                  55                  60                  
Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu Val Pro Lys Val Ala Thr 
65                  70                  75                  80  
Gln Thr Val Gly Gly Glu Glu Leu Pro Val Ala Gly Trp Arg Ser Tyr 
                85                  90                  95      
Leu Asn Met Glu Leu Thr Ile Pro Ile Phe Ala Thr Asn Ser Asp Cys 
            100                 105                 110         
Glu Leu Ile Val Lys Ala Met Gln Gly Leu Leu Lys Asp Gly Asn Pro 
        115                 120                 125             
Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly Ile Tyr Val Ile Ala Thr 
    130                 135                 140                 
Ala Ala Ala Gly Thr Asp Val Lys Asp Ala Lys Val Ile Ser Val Ser 
145                 150                 155                 160 
Thr Gly Thr Lys Cys Ile Asn Gly Glu Tyr Met Ser Asp Arg Gly Leu 
                165                 170                 175     
Ala Leu Asn Asp Cys His Ala Glu Ile Ile Ser Arg Arg Ser Leu Leu 
            180                 185                 190         
Arg Phe Leu Tyr Thr Gln Leu Glu Leu Tyr Leu Asn Asn Lys Asp Asp 
        195                 200                 205             
Gln Lys Arg Ser Ile Phe Gln Lys Ser Glu Arg Gly Gly Phe Arg Leu 
    210                 215                 220                 
Lys Glu Asn Val Gln Phe His Leu Tyr Ile Ser Thr Ser Pro Cys Gly 
225                 230                 235                 240 
Asp Ala Arg Ile Phe Ser Pro His Glu Pro Ile Leu Glu Gly Ser Arg 
                245                 250                 255     
Ser Tyr Thr Gln Ala Gly Val Gln Trp Cys Asn His Gly Ser Leu Gln 
            260                 265                 270         
Pro Arg Pro Pro Gly Leu Leu Ser Asp Pro Ser Thr Ser Thr Phe Gln 
        275                 280                 285             
Gly Ala Gly Thr Thr Glu Pro Ala Asp Arg His Pro Asn Arg Lys Ala 
    290                 295                 300                 
Arg Gly Gln Leu Arg Thr Lys Ile Glu Ser Gly Glu Gly Thr Ile Pro 
305                 310                 315                 320 
Val Arg Ser Asn Ala Ser Ile Gln Thr Trp Asp Gly Val Leu Gln Gly 
                325                 330                 335     
Glu Arg Leu Leu Thr Met Ser Cys Ser Asp Lys Ile Ala Arg Trp Asn 
            340                 345                 350         
Val Val Gly Ile Gln Gly Ser Leu Leu Ser Ile Phe Val Glu Pro Ile 
        355                 360                 365             
Tyr Phe Ser Ser Ile Ile Leu Gly Ser Leu Tyr His Gly Asp His Leu 
    370                 375                 380                 
Ser Arg Ala Met Tyr Gln Arg Ile Ser Asn Ile Glu Asp Leu Pro Pro 
385                 390                 395                 400 
Leu Tyr Thr Leu Asn Lys Pro Leu Leu Ser Gly Ile Ser Asn Ala Glu 
                405                 410                 415     
Ala Arg Gln Pro Gly Lys Ala Pro Asn Phe Ser Val Asn Trp Thr Val 
            420                 425                 430         
Gly Asp Ser Ala Ile Glu Val Ile Asn Ala Thr Thr Gly Lys Asp Glu 
        435                 440                 445             
Leu Gly Arg Ala Ser Arg Leu Cys Lys His Ala Leu Tyr Cys Arg Trp 
    450                 455                 460                 
Met Arg Val His Gly Lys Val Pro Ser His Leu Leu Arg Ser Lys Ile 
465                 470                 475                 480 
Thr Lys Pro Asn Val Tyr His Glu Ser Lys Leu Ala Ala Lys Glu Tyr 
                485                 490                 495     
Gln Ala Ala Lys Ala Arg Leu Phe Thr Ala Phe Ile Lys Ala Gly Leu 
            500                 505                 510         
Gly Ala Trp Val Glu Lys Pro Thr Glu Gln Asp Gln Phe Ser Leu Thr 
        515                 520                 525             
Pro 
    

<210> 37
<211> 521
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 37
Met Gly Ser Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly 
1               5                   10                  15      
Gly Thr Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Val 
            20                  25                  30          
Ala Glu Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr 
        35                  40                  45              
Cys Ser Val Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys 
    50                  55                  60                  
Val Glu Val Pro Lys Val Ala Thr Gln Thr Val Gly Gly Glu Glu Leu 
65                  70                  75                  80  
Pro Val Ala Gly Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro 
                85                  90                  95      
Ile Phe Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln 
            100                 105                 110         
Gly Leu Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn 
        115                 120                 125             
Ser Gly Ile Tyr Val Ile Ala Thr Ala Ala Ala Gly Thr Asp Val Lys 
    130                 135                 140                 
Asp Ala Lys Val Ile Ser Val Ser Thr Gly Thr Lys Cys Ile Asn Gly 
145                 150                 155                 160 
Glu Tyr Met Ser Asp Arg Gly Leu Ala Leu Asn Asp Cys His Ala Glu 
                165                 170                 175     
Ile Ile Ser Arg Arg Ser Leu Leu Arg Phe Leu Tyr Thr Gln Leu Glu 
            180                 185                 190         
Leu Tyr Leu Asn Asn Lys Asp Asp Gln Lys Arg Ser Ile Phe Gln Lys 
        195                 200                 205             
Ser Glu Arg Gly Gly Phe Arg Leu Lys Glu Asn Val Gln Phe His Leu 
    210                 215                 220                 
Tyr Ile Ser Thr Ser Pro Cys Gly Asp Ala Arg Ile Phe Ser Pro His 
225                 230                 235                 240 
Glu Pro Ile Leu Glu Gly Ser Arg Ser Tyr Thr Gln Ala Gly Val Gln 
                245                 250                 255     
Trp Cys Asn His Gly Ser Leu Gln Pro Arg Pro Pro Gly Leu Leu Ser 
            260                 265                 270         
Asp Pro Ser Thr Ser Thr Phe Gln Gly Ala Gly Thr Thr Glu Pro Ala 
        275                 280                 285             
Asp Arg His Pro Asn Arg Lys Ala Arg Gly Gln Leu Arg Thr Lys Ile 
    290                 295                 300                 
Glu Ser Gly Glu Gly Thr Ile Pro Val Arg Ser Asn Ala Ser Ile Gln 
305                 310                 315                 320 
Thr Trp Asp Gly Val Leu Gln Gly Glu Arg Leu Leu Thr Met Ser Cys 
                325                 330                 335     
Ser Asp Lys Ile Ala Arg Trp Asn Val Val Gly Ile Gln Gly Ser Leu 
            340                 345                 350         
Leu Ser Ile Phe Val Glu Pro Ile Tyr Phe Ser Ser Ile Ile Leu Gly 
        355                 360                 365             
Ser Leu Tyr His Gly Asp His Leu Ser Arg Ala Met Tyr Gln Arg Ile 
    370                 375                 380                 
Ser Asn Ile Glu Asp Leu Pro Pro Leu Tyr Thr Leu Asn Lys Pro Leu 
385                 390                 395                 400 
Leu Ser Gly Ile Ser Asn Ala Glu Ala Arg Gln Pro Gly Lys Ala Pro 
                405                 410                 415     
Asn Phe Ser Val Asn Trp Thr Val Gly Asp Ser Ala Ile Glu Val Ile 
            420                 425                 430         
Asn Ala Thr Thr Gly Lys Asp Glu Leu Gly Arg Ala Ser Arg Leu Cys 
        435                 440                 445             
Lys His Ala Leu Tyr Cys Arg Trp Met Arg Val His Gly Lys Val Pro 
    450                 455                 460                 
Ser His Leu Leu Arg Ser Lys Ile Thr Lys Pro Asn Val Tyr His Glu 
465                 470                 475                 480 
Ser Lys Leu Ala Ala Lys Glu Tyr Gln Ala Ala Lys Ala Arg Leu Phe 
                485                 490                 495     
Thr Ala Phe Ile Lys Ala Gly Leu Gly Ala Trp Val Glu Lys Pro Thr 
            500                 505                 510         
Glu Gln Asp Gln Phe Ser Leu Thr Pro 
        515                 520     

<210> 38
<211> 509
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 38
Met Ser Pro Lys Lys Lys Arg Lys Val Gly Ser Ala Ser Asn Phe Thr 
1               5                   10                  15      
Gln Phe Val Leu Val Asp Asn Gly Gly Thr Gly Asp Val Thr Val Ala 
            20                  25                  30          
Pro Ser Asn Phe Ala Asn Gly Val Ala Glu Trp Ile Ser Ser Asn Ser 
        35                  40                  45              
Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser Val Arg Gln Ser Ser Ala 
    50                  55                  60                  
Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu Val Pro Lys Val Ala Thr 
65                  70                  75                  80  
Gln Thr Val Gly Gly Glu Glu Leu Pro Val Ala Gly Trp Arg Ser Tyr 
                85                  90                  95      
Leu Asn Met Glu Leu Thr Ile Pro Ile Phe Ala Thr Asn Ser Asp Cys 
            100                 105                 110         
Glu Leu Ile Val Lys Ala Met Gln Gly Leu Leu Lys Asp Gly Asn Pro 
        115                 120                 125             
Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly Ile Tyr Val Ile Ala Thr 
    130                 135                 140                 
Ala Ala Ala Gly Arg Lys Ile Leu Ala Ala Ile Ile Met Lys Lys Asp 
145                 150                 155                 160 
Ser Glu Asp Met Gly Val Val Val Ser Leu Gly Thr Gly Asn Arg Cys 
                165                 170                 175     
Val Lys Gly Asp Ser Leu Ser Leu Lys Gly Glu Thr Val Asn Asp Cys 
            180                 185                 190         
His Ala Glu Ile Ile Ser Arg Arg Gly Phe Ile Arg Phe Leu Tyr Ser 
        195                 200                 205             
Glu Leu Met Lys Tyr Asn Ser Gln Thr Ala Lys Asp Ser Ile Phe Glu 
    210                 215                 220                 
Pro Ala Lys Gly Gly Glu Lys Leu Gln Ile Lys Lys Thr Val Ser Phe 
225                 230                 235                 240 
His Leu Tyr Ile Ser Thr Ala Pro Cys Gly Asp Gly Ala Leu Phe Asp 
                245                 250                 255     
Lys Ser Cys Ser Asp Arg Ala Met Glu Ser Thr Glu Ser Arg His Tyr 
            260                 265                 270         
Pro Val Phe Glu Asn Pro Lys Gln Gly Lys Leu Arg Thr Lys Val Glu 
        275                 280                 285             
Asn Gly Glu Gly Thr Ile Pro Val Glu Ser Ser Asp Ile Val Pro Thr 
    290                 295                 300                 
Trp Asp Gly Ile Arg Leu Gly Glu Arg Leu Arg Thr Met Ser Cys Ser 
305                 310                 315                 320 
Asp Lys Ile Leu Arg Trp Asn Val Leu Gly Leu Gln Gly Ala Leu Leu 
                325                 330                 335     
Thr His Phe Leu Gln Pro Ile Tyr Leu Lys Ser Val Thr Leu Gly Tyr 
            340                 345                 350         
Leu Phe Ser Gln Gly His Leu Thr Arg Ala Ile Cys Cys Arg Val Thr 
        355                 360                 365             
Arg Asp Gly Ser Ala Phe Glu Asp Gly Leu Arg His Pro Phe Ile Val 
    370                 375                 380                 
Asn His Pro Lys Val Gly Arg Val Ser Ile Tyr Asp Ser Lys Arg Gln 
385                 390                 395                 400 
Ser Gly Lys Thr Lys Glu Thr Ser Val Asn Trp Cys Leu Ala Asp Gly 
                405                 410                 415     
Tyr Asp Leu Glu Ile Leu Asp Gly Thr Arg Gly Thr Val Asp Gly Pro 
            420                 425                 430         
Arg Asn Glu Leu Ser Arg Val Ser Lys Lys Asn Ile Phe Leu Leu Phe 
        435                 440                 445             
Lys Lys Leu Cys Ser Phe Arg Tyr Arg Arg Asp Leu Leu Arg Leu Ser 
    450                 455                 460                 
Tyr Gly Glu Ala Lys Lys Ala Ala Arg Asp Tyr Glu Thr Ala Lys Asn 
465                 470                 475                 480 
Tyr Phe Lys Lys Gly Leu Lys Asp Met Gly Tyr Gly Asn Trp Ile Ser 
                485                 490                 495     
Lys Pro Gln Glu Glu Lys Asn Phe Tyr Leu Cys Pro Val 
            500                 505                 

<210> 39
<211> 501
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 39
Met Gly Ser Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly 
1               5                   10                  15      
Gly Thr Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Val 
            20                  25                  30          
Ala Glu Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr 
        35                  40                  45              
Cys Ser Val Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys 
    50                  55                  60                  
Val Glu Val Pro Lys Val Ala Thr Gln Thr Val Gly Gly Glu Glu Leu 
65                  70                  75                  80  
Pro Val Ala Gly Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro 
                85                  90                  95      
Ile Phe Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln 
            100                 105                 110         
Gly Leu Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn 
        115                 120                 125             
Ser Gly Ile Tyr Val Ile Ala Thr Ala Ala Ala Gly Arg Lys Ile Leu 
    130                 135                 140                 
Ala Ala Ile Ile Met Lys Lys Asp Ser Glu Asp Met Gly Val Val Val 
145                 150                 155                 160 
Ser Leu Gly Thr Gly Asn Arg Cys Val Lys Gly Asp Ser Leu Ser Leu 
                165                 170                 175     
Lys Gly Glu Thr Val Asn Asp Cys His Ala Glu Ile Ile Ser Arg Arg 
            180                 185                 190         
Gly Phe Ile Arg Phe Leu Tyr Ser Glu Leu Met Lys Tyr Asn Ser Gln 
        195                 200                 205             
Thr Ala Lys Asp Ser Ile Phe Glu Pro Ala Lys Gly Gly Glu Lys Leu 
    210                 215                 220                 
Gln Ile Lys Lys Thr Val Ser Phe His Leu Tyr Ile Ser Thr Ala Pro 
225                 230                 235                 240 
Cys Gly Asp Gly Ala Leu Phe Asp Lys Ser Cys Ser Asp Arg Ala Met 
                245                 250                 255     
Glu Ser Thr Glu Ser Arg His Tyr Pro Val Phe Glu Asn Pro Lys Gln 
            260                 265                 270         
Gly Lys Leu Arg Thr Lys Val Glu Asn Gly Glu Gly Thr Ile Pro Val 
        275                 280                 285             
Glu Ser Ser Asp Ile Val Pro Thr Trp Asp Gly Ile Arg Leu Gly Glu 
    290                 295                 300                 
Arg Leu Arg Thr Met Ser Cys Ser Asp Lys Ile Leu Arg Trp Asn Val 
305                 310                 315                 320 
Leu Gly Leu Gln Gly Ala Leu Leu Thr His Phe Leu Gln Pro Ile Tyr 
                325                 330                 335     
Leu Lys Ser Val Thr Leu Gly Tyr Leu Phe Ser Gln Gly His Leu Thr 
            340                 345                 350         
Arg Ala Ile Cys Cys Arg Val Thr Arg Asp Gly Ser Ala Phe Glu Asp 
        355                 360                 365             
Gly Leu Arg His Pro Phe Ile Val Asn His Pro Lys Val Gly Arg Val 
    370                 375                 380                 
Ser Ile Tyr Asp Ser Lys Arg Gln Ser Gly Lys Thr Lys Glu Thr Ser 
385                 390                 395                 400 
Val Asn Trp Cys Leu Ala Asp Gly Tyr Asp Leu Glu Ile Leu Asp Gly 
                405                 410                 415     
Thr Arg Gly Thr Val Asp Gly Pro Arg Asn Glu Leu Ser Arg Val Ser 
            420                 425                 430         
Lys Lys Asn Ile Phe Leu Leu Phe Lys Lys Leu Cys Ser Phe Arg Tyr 
        435                 440                 445             
Arg Arg Asp Leu Leu Arg Leu Ser Tyr Gly Glu Ala Lys Lys Ala Ala 
    450                 455                 460                 
Arg Asp Tyr Glu Thr Ala Lys Asn Tyr Phe Lys Lys Gly Leu Lys Asp 
465                 470                 475                 480 
Met Gly Tyr Gly Asn Trp Ile Ser Lys Pro Gln Glu Glu Lys Asn Phe 
                485                 490                 495     
Tyr Leu Cys Pro Val 
            500     

<210> 40
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> gRNA1

<400> 40
ctgtttctag tcttcaggtg agg                                            23


<210> 41
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> gRNA2

<400> 41
gctacctggg tgtgtgattg tgg                                            23


<210> 42
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Genotyping primer forward

<400> 42
tctggatggt aggcttctgc                                                20


<210> 43
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> Genotyping primer reverse

<400> 43
ctggaagcat agcagatgtg g                                              21


<210> 44
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> F2

<400> 44
gtctgggtgt tagtcagtta gtc                                            23


<210> 45
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> R2

<400> 45
cactctccca tgccactatc tgc                                            23


<210> 46
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> F3

<400> 46
gtctgggtgt tagtcagtta gtc                                            23


<210> 47
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> R4

<400> 47
cgtctaccca gtaccagatg ttg                                            23


<210> 48
<211> 9705
<212> DNA
<213> Artificial Sequence


<220> 
<223> linearized homologous recombination construct

<400> 48
tagaggtacc ggcggccgct ctagaactag tggatccccg taccgtttaa acgcctcgac       60

tctagtggat ctgcattcca ccactgctcc cattcatcag ttccataggt tggaatctaa      120

aatacacaaa caattagaat cagtagttta acacattata cacttaaaaa ttttatattt      180

accttagagc tttaaatctc tgtaggtagt ttgtccaatt atgtcacacc acagaagtaa      240

ggttccttca caaagagatc gcctgacacg atttcctgca caggcttgag ccatatactc      300

atacatcgca tcttggccac gttttccacg ggtttcaaaa ttaatctcaa gttctacgct      360

taacgctttc gcctgttccc agttattaat atattcaacg ctagaactcc cctcagcgaa      420

gggaaggctg agcactacac gcgaagcacc atcaccgaac cttttgataa actcttccgt      480

tccgacttgc tccatcaacg gttcagtgag acttaaacct aactctttct taatagtttc      540

ggcattatcc acttttagtg cgagaacctt cgtcagtcct ggatacgtca ctttgaccac      600

gcctccagct tttccagaga gcgggttttc attatctaca gagtatcccg cagcgtcgta      660

tttattgtcg gtactataaa accctttcca atcatcgtca taatttcctt gtgtaccaga      720

ttttggcttt tgtatacctt tttgaatgga atctacataa ccaggtttag tcccgtggta      780

cgaagaaaag ttttccatca caaaagattt agaagaatca acaacatcat caggatccat      840

ggcgaggacc tgcagggtcg ctcggtgttc gaggccacac gcgtcacctt aatatgcgaa      900

gtggacctgg gaccgcgccg ccccgactgc atctgcgtgt tcgaattcgc caatgacaag      960

acgctgggcg gggtttgctc gacattgggt ggaaacattc caggcctggg tggagaggct     1020

ttttgcttcc tcttgcaaaa ccacactgct cgacattggg tggaaacatt ccaggcctgg     1080

gtggagaggc tttttgcttc ctcttgaaaa ccacactgct cgaccgcgct tcggtacggg     1140

ctgcaggaat tcgatatcaa gctttcagaa ggcccaaatc attagctaga tgatacaggg     1200

caggcataaa ggaagttcat ggcagcatgg gcagcaggca actagggtaa tagctgaagt     1260

tgctatctga gtctcatgta gccagtgtga gaccaaggtc gaaaaggggg cttggtggca     1320

ggctggcaag ggggcccctt aaacttggtc ctcatataag tttggtgttc ctagctgctt     1380

tccttgtggg aggctgggct gcaggggtgc tctggctgcc aggccttaca atccacagct     1440

cccaagcctc cacagctgag ccccagatca taacattact gtcctttctc ttttcttggg     1500

cactatgggg ccctagaggc tgctcagatg ctctaccctt gcaaccctgc agtggtggct     1560

tgggactcct gtctcctgtt ccttgggtgc tgccactgct ttgccaagcc tgctgtgatg     1620

cactgctaac ccttctactt ccctgctgct tgctcttgcc tgtgccaggc tgtgctatgc     1680

tgcctctcat tgcaagcctc tggttgagca agcgttctca gttgtcagga gactccagtt     1740

tcaccttcag gcctcggggt tgggtaggga ggaaagtttc acatccccca cactgcagca     1800

ggactctgcc tcacttcatc cacacatagc actggggccc agggccagac cacgggtgta     1860

ggtagccatg ggcctggcca gagtgccggt ataagttagc ataggccatg ataccagctg     1920

aggctgagtt ggcagaggag gtagcagtaa atgcttgtgc tgggattgga tggtccctta     1980

cttgtcttcc caggtatctg ggtaccactt gttggtcttc tctcataaag gggcttgagg     2040

tggtcaggag aatccttcct gccttctgag aaaccactca ccatcgtagc ttggggtatg     2100

ggttgggcta gagattgggg ctggctgtgc ttggttgtag cagtaagagg cctggatggg     2160

tagcaagctg atgggggtag ccaaaatgtt cggctcacct gctggctccc ctctggggat     2220

tcactctgct ttaccaggtg ctggcattgg ccccaccatc cagattgggg aggagacggt     2280

gattactgtg gacacaaaag cagcaggcaa aggcaaagtg acttgtactg tgtgcacacc     2340

tgatggctca gaggtagacg tggacgtggt ggagaatgag gatggcacct ttgacatctt     2400

ctacacagct ccccaaccgg gcaaatatgt catctgtgtg cgcttcggtg gcgagcatgt     2460

gcccaacagc cccttccaag ttacagtgag aagaggccaa ggatgggtgg gcagggagat     2520

ctgggaaagt cctagcctgt ccttccaggt ccctttgtga caacagtctc caaccctctc     2580

actttgcccc acaggctttg gctggggacc aaccaacagt gcagacccca ttaaggtctc     2640

agcagctggc tccacagtat aactatcctc agggtagcca gcaaacctgg gtaaggcctg     2700

ggcctggtct attattcaat ttgtctaacc catagggaca cttgaagctg gccacctgga     2760

tgtctcatgt ggccctgaga aaccccatat cttctcatag cccctcacct gattcttctg     2820

tctctattgc agattccaga gaggcccatg gtgggcgtta atgggctgga tgtgaccagc     2880

ctgaggccct ttgatcttgt catccccttc actatcaaga agggggagat cactggtgag     2940

tgagggctag gaagaaactt ggaaactagt gatggccagg gtgttccaat ctcctggcct     3000

gacattgaaa ccactgctct gtaggggaag ttcgaatgcc ctcaggcaag gtggcccagc     3060

cttccattac tgataacaaa gatggcactg ttactgtacg ttactcaccc agtgaagctg     3120

gcctgcatga aatggacatt cgctatgaca atatgcatat cccaggtggg tgtattgcct     3180

cttgtccact ccatcctagg cccgtgttgc tatcatctca ggaagaacag gctagggctg     3240

ggttataggt cagttagtag agcctagcat gcatcaggct ctgaataaac taggtatcat     3300

ggcacatgcc tgtaatcata gccctcgagg caggaggatc agtggttcaa ggtcatcctt     3360

agcttcatag taagttcaaa gccagccaga gaaacataaa gaccctgttt caaaaacaga     3420

accaaaatga ctaacaaatg aatgagtctg gtattccatg tggcttctat tctggtctca     3480

ggaagccctc tgcagttcta tgttgattat gtcaactgtg gccacatcac tgcttatggt     3540

cctggcctta cccatggagt ggtcaacaaa cctgccacct tcactgtcaa caccaaggat     3600

gcaggagagg gtaaggagac gctctaggtt tgacctgccc aagttgtcct ccattggctg     3660

agaactgtat gtgggagatg atcctgaatg gtgttttcta ccttaccttc atgctgagcc     3720

atcaagtcaa ctcacccaca aaggttcagc aatgtgtctc tgggcacagt tctcactctt     3780

atctgtgata tttttcaggg ggcttgtctc tggccattga gggtccatct aaagcagaaa     3840

tcagttgcac tgacaaccag gatggaacat gcagtgtctc ttacctgcct gtactgcctg     3900

gtgactatag catcctagtt aagtacaatg atcaacacat cccaggcagt ccctttactg     3960

ccagagtaac aggtacggag catcgggagt aatgacagga acaggtggca tgaggtcaca     4020

gtctctttgg gctggatcta tagtggctga tggcttgcac ccttaccagg tgacgattcc     4080

atgcgtatgt cccacctaaa ggtgggttct gctgctgata tccccatcaa tatctcagaa     4140

acagacctta gcctactcac agccactgtg gtgccacctt cgggtcgaga ggaaccctgt     4200

ctgctgaaac gtttgcgaaa tggccacgtg ggtaagaggt caagagggag caaaagtttc     4260

tgtgaaagag ggaaagccag gtgtggtgac tgcccatagt cctaatactt gggaggtgta     4320

agtagaagaa tcaggggaac caatcattgg ctacataatg agttaaagtc attttagcct     4380

gtaataaata ccctgtgttc agacaaaggg agcaaggaag aagattgtgg gcccacatct     4440

tgttgatagc cctatcctgt gcctagggat ttccttcgtg cccaaggaga caggggagca     4500

cctggtacat gtgaagaaga atggccagca tgtggcaagc agtcccatcc cagtagtgat     4560

cagccagtcg gagataggtg atgccagccg tgtgagggtc tctggtcaag gtcttcatga     4620

aggtcatacc tttgagcctg cagagtttat tattgacacc agagatgcag gtaggcagtg     4680

tggtctgcta gttggggcaa tacagctagc tttccttggc attctggctt atagctgcta     4740

tctatttccc aggctacggt gggcttagtc tgtccattga gggccctagc aaagtagaca     4800

tcaacacaga ggatctggag gatggcacat gcagggtcac ctactgtccc acagagcctg     4860

gaaactacat tataaacatc aaatttgctg accagcatgt gcctggtgag tgtggcagcc     4920

atacccctta cctgtggttt ggcagcattg ctagtcacac acctcagtgc ccacctgtaa     4980

cttgtgcata gtatggattg tacttttttc ctacaggcag tcccttttct gtgaaggtga     5040

caggtgaggg ccgggtgaaa gagagtatca cacgcaggcg acgtgcccct tctgtggcca     5100

atattggcag tcattgtgac ctcagcctga agattcctgg tagggaaaag atcaggaggg     5160

tttctggggc aaccctaagc ataagtagag agacagggcc ctccctgctc accaagctat     5220

cttctatttg tagaaattag catccaagat atgacagccc aggtgaccag cccatcaggc     5280

aagacccatg aggcagagat cgtagaagga gagaaccata cttactgtat ccgatttgtg     5340

cctgctgaga tgggaatgca tacagtcagt gtcaagtaca agggccagca tgtacctggg     5400

agccccttcc agttcactgt ggggcctctg ggggaagggg gtgctcacaa ggtccgtgct     5460

ggaggccctg gcctagagag ggctgaagtt ggagtgccag gtaggtgtac ttgtctaatt     5520

cttgctatcc taggtgggcc taggtgggtg tttgtaggaa gtagccagca ggcatgttga     5580

tcttggcttt gcttagactt ggctgaggct gggaaccagt cctctgctcc atgagcacac     5640

actgctttcc cacagcggag ttcggcattt ggactaggga agctggcgct ggaggcctgg     5700

ccattgctgt tgaaggcccc agcaaggctg agatctcttt cgaggaccga aaggatggct     5760

cctgtggtgt ggcctacgta gttcaggagc caggtattgg aaacagaaat ggctggggta     5820

gggggaggta ggacctgagt gtgggtatgt tgaacccagg tgttacatag tctccacttg     5880

gttcttattc tccatcgtaa ggttccaggg acaaccaagg ggactgtggg agggaggcaa     5940

gaggcctttc ctaggctagc ctttggggat atgtggcacc tccaggtata gccttatgtt     6000

ctcttccttt ccaggtgact atgaggtctc agtcaagttc aacgaggagc acatacctga     6060

tagccccttc gtggtgcctg tggcttctcc gtctggtgac gcccgccgcc ttactgtttc     6120

tagtcttcag gtgaggcact gagagaaact gcccatctgg ggctcctggg cccggccaga     6180

ccagagtcac catagcaagc aggtcttggc cctgggctga gtgcctacgc agaaataatt     6240

ctggatggta ggcttctgct ctgggaattc cgatcatatt caataaccct taatataact     6300

tcgtataatg tatgctatac gaagttatta ggtctgaaga ggagtttacg tccagccaag     6360

cttgatatcg agggcccctg caggtcaatt ctaccgggta ggggaggcgc ttttcccaag     6420

gcagtctgga gcatgcgctt tagcagcccc gctgggcact tggcgctaca caagtggcct     6480

ctggcctcgc acacattcca catccaccgg taggcgccaa ccggctccgt tctttggtgg     6540

ccccttcgcg ccaccttcta ctcctcccct agtcaggaag ttcccccccg ccccgcagct     6600

cgcgtcgtgc aggacgtgac aaatggaagt agcacgtctc actagtctcg tgcagatgga     6660

cagcaccgct gagcaatgga agcgggtagg cctttggggc agcggccaat agcagctttg     6720

ctccttcgct ttctgggctc agaggctggg aaggggtggg tccgggggcg ggctcagggg     6780

cgggctcagg ggcggggcgg gcgcccgaag gtcctccgga ggcccggcat tctgcacgct     6840

tcaaaagcgc acgtctgccg cgctgttctc ctctttatca ggacatagcg ttggctaccc     6900

gtgatattgc tgaagagctt ggcggcgaat gggctgaccg cttcctcgtg ctttacggta     6960

tcgccgctcc cgattcgcag cgcatcgcct tctatcgcct tcttgacgag ttcttctgag     7020

gggatcgatc cgctgtaagt ctgcagaaat tgatgatcta ttaaacaata aagatgtcca     7080

ctaaaatgga agtttttcct gtcatacttt gttaagaagg gtgagaacag agtacctaca     7140

ttttgaatgg aaggattgga gctacggggg tgggggtggg gtgggattag ataaatgcct     7200

gctctttact gaaggctctt tactattgct ttatgataat gtttcatagt tggatatcat     7260

aatttaaaca agcaaaacca aattaagggc cagctcattc ctcccactca tgaccctata     7320

gatctataga tctctcgtgg gatcattgtt tttctcttga ttcccacttt gtggttctaa     7380

gtactgtggt ttccaaatgt gtcagtttca tagcctgaag aacgagatca gcagcctctg     7440

ttccacatac acttcattct cagtattgtt ttgccaagtt ctaattccat cagaagctga     7500

ctctagagct tgcggaaccc ttaatataac ttcgtataat gtatgctata cgaagttatt     7560

aggtccctcg aagcttatcg attgtggaga acatgtttag gagataggag gttgggggta     7620

tgcctgtggc ttgctgccct cacagatcaa tggctctccc tctttaaacc atgttggaca     7680

ccagatgggt aagtgactct gtcggtcttc tgctctccca tttgccctgg ttctatacat     7740

cctgtctaac cacatctgct atgcttccag gagtcagggt taaaggtcaa ccagccagca     7800

tcttttgcag tcagtctgaa tggagccaag ggggcaattg atgccaaggt gcacagcccc     7860

tcaggagctc tggaggagtg ctatgtcaca gagattgacc aaggtgaggc tctatccctg     7920

cctattcatc caaccatttg acctagctga ctagaagtag gctaatgtag tgattcaaaa     7980

gtgggctcct cagctaaaaa acccttccca gattgacaag cacccaggaa gataatggct     8040

ttccatcatg gccactagga agaacacctt acaccagtgt catacatgag aaagacataa     8100

aaacagagac agagagatag tcaatccctg gggctagaga aatggcaatt ctattgaagc     8160

acactagttt cactagtttc cctttccccc aagtccatga cctgaagcag attcctcccc     8220

atctctaagc ctgctgcttt gtacactgct acagtacact ctctaaggaa acagtaaggc     8280

aggcattttg cttgttattc caaaagactt acaagtagac ttcttaggta ttgatagcct     8340

tagtctcagg atgtatgtta ttggatgaat acctagaata attctggaag cagagggatc     8400

tccattgagc agctggattc ctgctagtgg caagagaagt gaaggggatg ttaaccaatt     8460

ctgttccttt cagatagtat tttcaagttg catacaaaaa agtaccccaa atcccttacc     8520

tgcatttcag ataagtatgc tgtgcgtttc atcccacgag agaatggcat ctacttgatt     8580

gatgtcaagt tcaatggtac tcacattcct ggaagtccct tcaagatccg agttggggag     8640

cctgggcatg gaggggaccc aggcttagtg tccgcctatg gagcaggcct ggaaggtggt     8700

gtcacaggta ggtttatggg tacagctctg agtgtagatg tatagcccca gcaccaggaa     8760

gcatgtggaa gtatcaaggc tgtgctgggt agctgaatgc aaggaagcca gtgagataga     8820

ttctgcctga ccttctattt tcccagggag cccagcagag tttattgtga acacaagcaa     8880

tgcaggagct ggtgcccttt cggttaccat tgatggcccc tccaaggtga agatggattg     8940

ccaggagtgc cccgagggct atcgtgtcac ctataccccc atggcacctg gcagctacct     9000

catctccatc aagtatggtg gcccctatca cattggtgga agtcccttta aagccaaggt     9060

cacaggtgag ccttaggcta agctgttggt ggccacccaa tgccttgata cttgagcagc     9120

ttcttagtct cacccattct gttttgtagg tcctcgtctt gtaagcaacc acagcctcca     9180

tgagacatca tctgtgtttg tggactcttt gactaaagtt gccacggttc cccagcatgc     9240

aacctcaggc ccaggtcctg ctgatgtcag caaggtagta gccaaaggcc tggggctaag     9300

caaggcttat gtaggccaga agagcaactt cacagtagat tgcagcaaag caggtgagta     9360

gccctatttt tagcttctgg aagtcgacgg tatcgataag cttgatatcg aattcctgca     9420

gcccgtaccg aagcgcggtc gagcagtgtg gttttcaaga ggaagcaaaa agcctctcca     9480

cccaggcctg gaatgtttcc acccaatgtc gagcagtgtg gttttgcaag aggaagcaaa     9540

aagcctctcc acccaggcct ggaatgtttc cacccaatgt cgagcaaacc ccgcccagcg     9600

tcttgtcatt ggcgaattcg aacacgcaga tgcagtcggg gcggcgcggt cccaggtcca     9660

cttcgcatat taaggtgacg cgaaacggta cggggatcca ctagt                     9705


<210> 49
<211> 4032
<212> DNA
<213> Artificial Sequence


<220> 
<223> Homology directed repair construct for FLNAR mouse

<400> 49
gcgaggtcaa gagggagcaa aagtttctgt gaaagaggga aagccaggtg tggtgactgc       60

ccatagtcct aatacttggg aggtgtaagt agaagaatca ggggaaccaa tcattggcta      120

cataatgagt taaagtcatt ttagcctgta ataaataccc tgtgttcaga caaagggagc      180

aaggaagaag attgtgggcc cacatcttgt tgatagccct atcctgtgcc tagggatttc      240

cttcgtgccc aaggagacag gggagcacct ggtacatgtg aagaagaatg gccagcatgt      300

ggcaagcagt cccatcccag tagtgatcag ccagtcggag ataggtgatg ccagccgtgt      360

gagggtctct ggtcaaggtc ttcatgaagg tcataccttt gagcctgcag agtttattat      420

tgacaccaga gatgcaggta ggcagtgtgg tctgctagtt ggggcaatac agctagcttt      480

ccttggcatt ctggcttata gctgctatct atttcccagg ctacggtggg cttagtctgt      540

ccattgaggg ccctagcaaa gtagacatca acacagagga tctggaggat ggcacatgca      600

gggtcaccta ctgtcccaca gagcctggaa actacattat aaacatcaaa tttgctgacc      660

agcatgtgcc tggtgagtgt ggcagccata ccccttacct gtggtttggc agcattgcta      720

gtcacacacc tcagtgccca cctgtaactt gtgcatagta tggattgtac ttttttccta      780

caggcagtcc cttttctgtg aaggtgacag gtgagggccg ggtgaaagag agtatcacac      840

gcaggcgacg tgccccttct gtggccaata ttggcagtca ttgtgacctc agcctgaaga      900

ttcctggtag ggaaaagatc aggagggttt ctggggcaac cctaagcata agtagagaga      960

cagggccctc cctgctcacc aagctatctt ctatttgtag aaattagcat ccaagatatg     1020

acagcccagg tgaccagccc atcaggcaag acccatgagg cagagatcgt agaaggagag     1080

aaccatactt actgtatccg atttgtgcct gctgagatgg gaatgcatac agtcagtgtc     1140

aagtacaagg gccagcatgt acctgggagc cccttccagt tcactgtggg gcctctgggg     1200

gaagggggtg ctcacaaggt ccgtgctgga ggccctggcc tagagagggc tgaagttgga     1260

gtgccaggta ggtgtacttg tctaattctt gctatcctag gtgggcctag gtgggtgttt     1320

gtaggaagta gccagcaggc atgttgatct tggctttgct tagacttggc tgaggctggg     1380

aaccagtcct ctgctccatg agcacacact gctttcccac agcggagttc ggcatttgga     1440

ctagggaagc tggcgctgga ggcctggcca ttgctgttga aggccccagc aaggctgaga     1500

tctctttcga ggaccgaaag gatggctcct gtggtgtggc ctacgtagtt caggagccag     1560

gtattggaaa cagaaatggc tggggtaggg ggaggtagga cctgagtgtg ggtatgttga     1620

acccaggtgt tacatagtct ccacttggtt cttattctcc atcgtaaggt tccagggaca     1680

accaagggga ctgtgggagg gaggcaagag gcctttccta ggctagcctt tggggatatg     1740

tggcacctcc aggtatagcc ttatgttctc ttcctttcca ggtgactatg aggtctcagt     1800

caagttcaac gaggagcaca tacctgatag ccccttcgtg gtgcctgtgg cttctccgtc     1860

tggtgacgcc cgccgcctta ctgtttctag tcttcgggtg aggcactgag agaaactgcc     1920

catctggggc tcctgggccc ggccagacca gagtcaccat agcaagcagg tcttggccct     1980

gggctgagtg cctacgcaga aataattctg gatggtaggc ttctgctctg ggattgtgga     2040

gaacatgttt aggagatagg aggttggggg tatgcctgtg gcttgctgcc ctcacagatc     2100

aatggctctc cctctttaaa ccatgttgga caccagatgg gtaagtgact ctgtcggtct     2160

tctgctctcc catttgccct ggttctatac atcctgtcta accacatctg ctatgcttcc     2220

aggagtcagg gttaaaggtc aaccagccag catcttttgc agtcagtctg aatggagcca     2280

agggggcaat tgatgccaag gtgcacagcc cctcaggagc tctggaggag tgctatgtca     2340

cagagattga ccaaggtgag gctctatccc tgcctattca tccaaccatt tgacctagct     2400

gactagaagt aggctaatgt agtgattcaa aagtgggctc ctcagctaaa aaacccttcc     2460

cagattgaca agcacccagg aagataatgg ctttccatca tggccactag gaagaacacc     2520

ttacaccagt gtcatacatg agaaagacat aaaaacagag acagagagat agtcaatccc     2580

tggggctaga gaaatggcaa ttctattgaa gcacactagt ttcactagtt tccctttccc     2640

ccaagtccat gacctgaagc agattcctcc ccatctctaa gcctgctgct ttgtacactg     2700

ctacagtaca ctctctaagg aaacagtaag gcaggcattt tgcttgttat tccaaaagac     2760

ttacaagtag acttcttagg tattgatagc cttagtctca ggatgtatgt tattggatga     2820

atacctagaa taattctgga agcagaggga tctccattga gcagctggat tcctgctagt     2880

ggcaagagaa gtgaagggga tgttaaccaa ttctgttcct ttcagatagt attttcaagt     2940

tgcatacaaa aaagtacccc aaatccctta cctgcatttc agataagtat gctgtgcgtt     3000

tcatcccacg agagaatggc atctacttga ttgatgtcaa gttcaatggt actcacattc     3060

ctggaagtcc cttcaagatc cgagttgggg agcctgggca tggaggggac ccaggcttag     3120

tgtccgccta tggagcaggc ctggaaggtg gtgtcacagg taggtttatg ggtacagctc     3180

tgagtgtaga tgtatagccc cagcaccagg aagcatgtgg aagtatcaag gctgtgctgg     3240

gtagctgaat gcaaggaagc cagtgagata gattctgcct gaccttctat tttcccaggg     3300

agcccagcag agtttattgt gaacacaagc aatgcaggag ctggtgccct ttcggttacc     3360

attgatggcc cctccaaggt gaagatggat tgccaggagt gccccgaggg ctatcgtgtc     3420

acctataccc ccatggcacc tggcagctac ctcatctcca tcaagtatgg tggcccctat     3480

cacattggtg gaagtccctt taaagccaag gtcacaggtg agccttaggc taagctgttg     3540

gtggccaccc aatgccttga tacttgagca gcttcttagt ctcacccatt ctgttttgta     3600

ggtcctcgtc ttgtaagcaa ccacagcctc catgagacat catctgtgtt tgtggactct     3660

ttgactaaag ttgccacggt tccccagcat gcaacctcag gcccaggtcc tgctgatgtc     3720

agcaaggtag tagccaaagg cctggggcta agcaaggctt atgtaggcca gaagagcaac     3780

ttcacagtag attgcagcaa agcaggtgag tagccctatt tttagcttct ggaagtgcaa     3840

agccataaat aacaggatgg tcagcatgta ggaagtacag gaactgcctt taggggtatg     3900

attattgctt ttagagctac cttctatttg ggccttcgta ctttcctttc tacccttcaa     3960

gaaaatgtcc tggagtgggg ctgctgaaaa ggtggctcag cagttttcag aggactgggg     4020

ttcaagtcac ag                                                         4032


<210> 50
<211> 8496
<212> RNA
<213> Mus musculus


<220> 
<223> Filamin A mRNA, transcript variant X2

<400> 50
cuuggaacag agccuccuuu cuaaccagga aacacuuggc uccccuacac ucaucuagcc       60

ucauaaaggu ugguccuaaa cauaggguuu gcagacccug cucuggagug caaccucugu      120

ucugugccuc gucguucaug cucggaggug ccuacugcuu uaauuaaagg gccgucccau      180

cggcgaagcu gcagcaccgc cccuccguuc cucgcgccuc aaaaugagua gcucucacuc      240

ccgcuguggc cagagugcgg cgguugcguc uccgggaggc aguaucgauu cacgggacgc      300

ggagaugccg gcuaccgaaa aagaccuagc agaagaugca ccguggaaga aaauucagca      360

gaacacauuc acccgcuggu gcaaugagca ccuuaagugc guaagcaagc gcaucgccaa      420

ucugcagacg gaccugagcg auggguugcg gcucaucgcg cugcucgagg uacucagcca      480

gaagaaaaug caccgcaagc acaaccaaag acccacuuuc cgccagaugc agcucgaaaa      540

ugugucggug gcgcuugaau uccuggaccg ugagagcauc aagcucgugu ccauagacag      600

caaggcuauu guggauggaa aucugaagcu gaucuuaggc cucaucugga cccugauccu      660

gcacuauucc aucucaaugc ccauguggga ugaggaagag gaugaggagg ccaagaagca      720

aacacccaag cagaggcuuc uaggcuggau ucagaacaag cuaccacagc uucccauuac      780

caacuucagu cgagacuggc agaguggccg ggcccugggu gcucuuguug auagcugugc      840

cccaggccua uguccugacu gggacuccug ggaugcuagu aagccuguga acaaugcacg      900

ggaagccaug cagcaggcug augacuggcu aggcauuccu caggugauua ccccagaaga      960

aauuguggac cccaauguag augagcauuc uguuaugacc uaccugucuc aguuucccaa     1020

ggccaagcug aagccagggg cuccucuucg gcccaaacug aacccgaaga aagcccgagc     1080

cuaugggcca ggcaucgagc cuacaggcaa uauggugaag aagagagcag aauucacugu     1140

ggagacccga agugcuggac agggagaagu gcuuguauau guggaggacc cagcuggaca     1200

ccaggaagag gcaaaaguga cugccaauaa ugacaagaac cguacuuucu cugucuggua     1260

ugucccugaa gugacaggga cucauaaggu gacugugcuc uuugcuggcc aacauauugc     1320

caagagcccc uuugaggugu auguggacaa gucacagggu gaugccagca aagugacugc     1380

ccagggcccu ggucuggagc ccaguggcaa uauugccaac aagacuaccu acuuugagau     1440

cuucacugca ggagcuggca ugggugaggu ggaaguuguc auccaggacc cuacaggaca     1500

gaaaggcaca guggaaccuc agcuggaggc caggggugac agcaccuauc gcuguagcua     1560

ucagcccacc auggagggug uccauacagu acaugucacc uucgccggug uucccauccc     1620

ucguagcccc uacacuguca cuguuggcca agccuguaac ccagcugccu gccgggcuau     1680

ugguagaggc cuucagccca aggguguucg agugaaggaa acagccgacu ucaaggugua     1740

cacaaagggc gcuggcagug gggagcuaaa ggucacugua aaggguccca agggugagga     1800

gcguguaaag cagaaggacu uaggggaugg uguguauggc uuugaauauu acccuacaau     1860

cccuggcaca uacacuguca ccaucacaug ggguggccag aacauugguc gaaguccguu     1920

ugaggugaag guaggcacug aguguggcaa ucagaaaguu cgggcauggg guccuggccu     1980

ggaaggaggc auuguuggca agucagcaga cuucguagua gaggccauug gugaugaugu     2040

gggcaccuug gguuucucug uggaaggucc aucacaggca aagauugaau gugacgacaa     2100

gggugauggc uccugugaug ugcgcuauug gccccaggag gcuggcgagu augcuguuca     2160

ugugcugugu aacagugagg auauccgucu caguccuuuc auggcugaca uccgugaggc     2220

accccaggau uuucacccag acagggugaa ggcacguggg ccuggauugg agaagacugg     2280

uguggcuguc aacaagccag cagaguucac aguugaugcc aagcaugcug ggaaggcucc     2340

ucuucgaguu caaguucagg acaaugaggg cugcucugug gaagcgacag ucaaggacaa     2400

uggcaauggu acuuacagcu guucuuaugu gcccagaaag ccagugaagc acacagccau     2460

gguuucuugg ggagguguca gcauccccaa caguccuuuc cgggugaaug ugggagcugg     2520

cagccaucca aacaaaguca agguguaugg uccaggagug gccaagacug ggcucaaggc     2580

ccaugaaccu accuacuuua cuguggauug uacugaagcu ggccagggag augucagcau     2640

ugguaucaag ugugccccug gaguaguggg ccccacugag gcugauauug acuuugauau     2700

cauccgcaau gacaaugaca ccuucacugu aaaauacaca cccugugggg cuggcagcua     2760

uaccaucaug guccuuuuug cugaccaggc cacacccacc agccccauca gagucaaagu     2820

ggagccuucu caugaugcca gcaaggugaa ggcugagggu ccuggccuaa aucgcacugg     2880

uguugaacuu ggcaaaccca cccauuucac agucaaugcu aaaacugcug ggaaaggcaa     2940

gcuggauguc caauucucag gacuggcuaa gggagaugca guacgggaug uggacaucau     3000

ugaccaccau gauaauaccu acacagucaa guacauuccu gugcagcagg gcccaguagg     3060

ugucaauguc acuuauggag gagaucacau ccccaagagu ccauuuucag ugggaguauc     3120

uccaagccug gaucucagca aaaucaaggu gucuggccuu ggugacaaag uggacguugg     3180

caaagaucaa gaguucacag uaaagucaaa gggugcaggu ggucaaggca aaguagcauc     3240

caagauugug agucccucag gugcagcggu acccugcaag guagagccag gccugggagc     3300

ugacaacagc gugguacguu uugugccccg ugaagagggg cccuaugagg uggaagugac     3360

cuaugauggu gugccuguac cuggcagucc cuuuccacua gaagcugugg cccccaccaa     3420

acccagcaag gugaaggcgu uuggaccagg gcuacagggg ggcaaugcag gcuccccugc     3480

ccgcuucacc auugauacaa agggugcugg cacugguggc cugggccuga caguggaagg     3540

ccccugugaa gcacagcuug agugccuaga caacggggau gguacaugcu cugugucuua     3600

uguacccacu gagccugggg acuacaacau caacauccuu uuugcugaca cccacauucc     3660

uggaucccca uucaaggccc auguggcucc uuguuuugau gcauccaagg ugaagugcuc     3720

aggcccuggg cuggagcggg cuacugcugg ugagguaggg caguuccaag uggacuguuc     3780

aagugcuggc agugcugagu ugacgauuga gaucugcucu gaggcaggac ugccagcuga     3840

aguauacauu caagaccaug gugauggcac acacaccauu accuauauuc cucucugucc     3900

uggggcuuac acuguuacca ucaaguaugg cggccagccu gugcccaacu uccccagcaa     3960

gcuacaggug gaaccugcug uagauaccuc agguguacag ugcuaugggc cugggauuga     4020

aggucaaggu gucuuccgag aggcaaccac ugaguucagu guggaugccc gggcucuuac     4080

acagacugga gggccacaug ucaaggcucg aguggccaac cccucaggca aucugacaga     4140

uaccuaugug caagacugug gggauggcac auacaaagug gaauacacuc cauaugagga     4200

aggaguacac ucuguggaug ugacuuauga uggcagcccu gugcccagca gccccuucca     4260

ggugccugua acagagggcu gugaccccuc ccgggugcgu guccauggac caggcaucca     4320

aagugguacc accaacaaac ccaacaaguu cacaguagaa accaggggag cuggcacagg     4380

uggccugggc uuggcuguug agggucccuc agaggccaag augucuugua uggauaauaa     4440

agauggcagc ugcucaguag aauacauccc cuaugaagcu ggaaccuaua gccuuaaugu     4500

cacuuauggu ggucaccaag ugccagguag ucccuucaag gucccuguac augaugugac     4560

agaugcaucu aaagucaagu guucuggacc uggccuaagc ccaggcaugg uccgugccaa     4620

ccucccucag uccuuucagg uggacacaag caaagcugga guugccccac ugcaggucaa     4680

agugcagggg cccaaaggcc ugguggagcc aguggaugua guggacaaug cugaugguac     4740

ucagacuguc aacuaugugc ccagccgaga aggguccuau agcauuucug ugcuguaugg     4800

ugaagaagaa gugccacgga gccccuucaa ggucaaggug cugccuacac augaugccag     4860

uaaggugaag gccaguggac cuggacucaa caccacuggu guaccugcua gccugccugu     4920

ggaguucacc auugaugcca aggaugcugg ggagggucug uuggcugucc agauuacgga     4980

uccugaaggc aagcccaaga agacacacau ucaagauaau caugauggca cauacacggu     5040

ggcuuaugug ccagaugugc caggccggua cacaauccuc aucaaguaug guggugauga     5100

gauucccuuu uccccguacc guguccgggc ugugcccacu ggggaugcca gcaagugcac     5160

agucacagug ucaaucggag gucacgggcu aggugcuggc auuggcccca ccauccagau     5220

uggggaggag acggugauua cuguggacac aaaagcagca ggcaaaggca aagugacuug     5280

uacugugugc acaccugaug gcucagaggu agacguggac gugguggaga augaggaugg     5340

caccuuugac aucuucuaca cagcucccca accgggcaaa uaugucaucu gugugcgcuu     5400

cgguggcgag caugugccca acagccccuu ccaaguuaca gcuuuggcug gggaccaacc     5460

aacagugcag accccauuaa ggucucagca gcuggcucca caguauaacu auccucaggg     5520

uagccagcaa accuggauuc cagagaggcc cauggugggc guuaaugggc uggaugugac     5580

cagccugagg cccuuugauc uugucauccc cuucacuauc aagaaggggg agaucacugg     5640

ggaaguucga augcccucag gcaagguggc ccagccuucc auuacugaua acaaagaugg     5700

cacuguuacu guacguuacu cacccaguga agcuggccug caugaaaugg acauucgcua     5760

ugacaauaug cauaucccag gaagcccucu gcaguucuau guugauuaug ucaacugugg     5820

ccacaucacu gcuuaugguc cuggccuuac ccauggagug gucaacaaac cugccaccuu     5880

cacugucaac accaaggaug caggagaggg gggcuugucu cuggccauug aggguccauc     5940

uaaagcagaa aucaguugca cugacaacca ggauggaaca ugcagugucu cuuaccugcc     6000

uguacugccu ggugacuaua gcauccuagu uaaguacaau gaucaacaca ucccaggcag     6060

ucccuuuacu gccagaguaa caggugacga uuccaugcgu augucccacc uaaagguggg     6120

uucugcugcu gauaucccca ucaauaucuc agaaacagac cuuagccuac ucacagccac     6180

uguggugcca ccuucggguc gagaggaacc cugucugcug aaacguuugc gaaauggcca     6240

cguggggauu uccuucgugc ccaaggagac aggggagcac cugguacaug ugaagaagaa     6300

uggccagcau guggcaagca gucccauccc aguagugauc agccagucgg agauagguga     6360

ugccagccgu gugagggucu cuggucaagg ucuucaugaa ggucauaccu uugagccugc     6420

agaguuuauu auugacacca gagaugcagg cuacgguggg cuuagucugu ccauugaggg     6480

cccuagcaaa guagacauca acacagagga ucuggaggau ggcacaugca gggucaccua     6540

cugucccaca gagccuggaa acuacauuau aaacaucaaa uuugcugacc agcaugugcc     6600

uggcaguccc uuuucuguga aggugacagg ugagggccgg gugaaagaga guaucacacg     6660

caggcgacgu gccccuucug uggccaauau uggcagucau ugugaccuca gccugaagau     6720

uccugaaauu agcauccaag auaugacagc ccaggugacc agcccaucag gcaagaccca     6780

ugaggcagag aucguagaag gagagaacca uacuuacugu auccgauuug ugccugcuga     6840

gaugggaaug cauacaguca gugucaagua caagggccag cauguaccug ggagccccuu     6900

ccaguucacu guggggccuc ugggggaagg gggugcucac aagguccgug cuggaggccc     6960

uggccuagag agggcugaag uuggagugcc agcggaguuc ggcauuugga cuagggaagc     7020

uggcgcugga ggccuggcca uugcuguuga aggccccagc aaggcugaga ucucuuucga     7080

ggaccgaaag gauggcuccu gugguguggc cuacguaguu caggagccag gugacuauga     7140

ggucucaguc aaguucaacg aggagcacau accugauagc cccuucgugg ugccuguggc     7200

uucuccgucu ggugacgccc gccgccuuac uguuucuagu cuucaggagu caggguuaaa     7260

ggucaaccag ccagcaucuu uugcagucag ucugaaugga gccaaggggg caauugaugc     7320

caaggugcac agccccucag gagcucugga ggagugcuau gucacagaga uugaccaaga     7380

uaaguaugcu gugcguuuca ucccacgaga gaauggcauc uacuugauug augucaaguu     7440

caaugguacu cacauuccug gaagucccuu caagauccga guuggggagc cugggcaugg     7500

aggggaccca ggcuuagugu ccgccuaugg agcaggccug gaagguggug ucacagggag     7560

cccagcagag uuuauuguga acacaagcaa ugcaggagcu ggugcccuuu cgguuaccau     7620

ugauggcccc uccaagguga agauggauug ccaggagugc cccgagggcu aucgugucac     7680

cuauaccccc auggcaccug gcagcuaccu caucuccauc aaguauggug gccccuauca     7740

cauuggugga agucccuuua aagccaaggu cacagguccu cgucuuguaa gcaaccacag     7800

ccuccaugag acaucaucug uguuugugga cucuuugacu aaaguugcca cgguucccca     7860

gcaugcaacc ucaggcccag guccugcuga ugucagcaag guaguagcca aaggccuggg     7920

gcuaagcaag gcuuauguag gccagaagag caacuucaca guagauugca gcaaagcagg     7980

uaacaacaug cugcuggugg gcgugcaugg cccaaggaca cccugugaag agauccuggu     8040

gaaacacaug ggcagccgcc ucuauagugu cucuuaccug cucaaggaca aaggggagua     8100

cacacuggug gucaaguggg gugaugagca uaucccaggc agcccauacc gcauuauggu     8160

acccugagcc ugccaccuaa guuggcaccu gugccagcua gaagcuccca uggcaaugag     8220

cauccccaca ccuguccuau ucccaagaag ccccauuuuc cuuuccugag cccuggaccc     8280

ucccuucccu ggaucacucu ggccgcucuu cacugcauuc gcccuugccc ugcacugugu     8340

ucaccugucu cugggcuuuc acuugggcag agggagccau uugguggcag agcaugucuu     8400

cuuugguucu gggaggugga aguccuaugu acaaccaccu ucuaguucuc uuucccagcc     8460

aagaggaaua aaauuuugcu uccguugucc ugugaa                               8496


<210> 51
<211> 50
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic oligonucleotide

<400> 51
aaagaugcug gcugguugac cuuuaacccu gacucccgaa gacuagaaac                50


<210> 52
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer

<400> 52
gtcaagttca acgaggagca c                                              21


<210> 53
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer

<400> 53
gtgcaccttg gcatcaattg c                                              21


<210> 54
<211> 658
<212> DNA
<213> Artificial Sequence


<220> 
<223> modified mouse DNA

<400> 54
ctttcctagg ctagcctttg gggatatgtg gcacctccag gtatagcctt atgttctctt      60

cctttccagg tgactatgag gtctcagtca agttcaacga ggagcacata cctgatagcc     120

ccttcgtggt gcctgtggct tctccgtctg gtgacgcccg ccgccttact gtttctagtc     180

ttcgggtgag gcactgagag aaactgccca tctggggctc ctgggcccgg ccagaccaga     240

gtcaccatag caagcaggtc ttggccctgg gctgagtgcc tacgcagaaa taattctgga     300

tggtaggctt ctgctctggg attgtggaga acatgtttag gagataggag gttgggggta     360

tgcctgtggc ttgctgccct cacagatcaa tggctctccc tctttaaacc atgttggaca     420

ccagatgggt aagtgactct gtcggtcttc tgctctccca tttgccctgg ttctatacat     480

cctgtctaac cacatctgct atgcttccag gagtcagggt taaaggtcaa ccagccagca     540

tcttttgcag tcagtctgaa tggagccaag ggggcaattg atgccaaggt gcacagcccc     600

tcaggagctc tggaggagtg ctatgtcaca gagattgacc aaggtgaggc tctatccc       658


<210> 55
<211> 26
<212> DNA
<213> Artificial Sequence


<220> 
<223> part of mouse Filamin A cDNA

<400> 55
ctagtcttca ggagtcaggg ttaaag                                         26


<210> 56
<211> 50
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic oligonucleotide

<400> 56
aaagaggcug gcugguugac cuuuagcccu gacucccgaa ggcuagaaac                50


