                         SEQUENCE LISTING

<110>  UCB Biopharma SRL
 
<120>  ANTIBODIES AGAINST KLK5

<130>  PF0197-WO

<150>  GB2008022.2
<151>  2020-05-28

<150>  GB2001447.8
<151>  2020-02-03

<160>  186   

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1

<400>  1

Gln Ser Ser Gln Ser Val Tyr Asn Asn Asn Asp Leu Ala 
1               5                   10              


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2

<400>  2

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  3
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3

<400>  3

Leu Gly Gly Tyr Asp Asp Asp Val Asp Thr Tyr Thr 
1               5                   10          


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1

<400>  4

Gly Phe Ser Leu Ser Ser Tyr Gly Met Ser 
1               5                   10  


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  5

Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  6
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  6

Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Pro 
            20  


<210>  7
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 Q1R

<400>  7

Arg Ser Ser Gln Ser Val Tyr Asn Asn Asn Asp Leu Ala 
1               5                   10              


<210>  8
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 Q1K

<400>  8

Lys Ser Ser Gln Ser Val Tyr Asn Asn Asn Asp Leu Ala 
1               5                   10              


<210>  9
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 Q1H

<400>  9

His Ser Ser Gln Ser Val Tyr Asn Asn Asn Asp Leu Ala 
1               5                   10              


<210>  10
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 D19N

<400>  10

Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr Tyr 
1               5                   10                  15      


Gly Met Asn Pro 
            20  


<210>  11
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 D19E

<400>  11

Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr Tyr 
1               5                   10                  15      


Gly Met Glu Pro 
            20  


<210>  12
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 Y4F

<400>  12

Asp His Ile Phe Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Pro 
            20  


<210>  13
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 Y6F

<400>  13

Asp His Ile Tyr Arg Phe Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Pro 
            20  


<210>  14
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 Y9F

<400>  14

Asp His Ile Tyr Arg Tyr Asp Asp Phe Gly Asp Tyr Pro Thr Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Pro 
            20  


<210>  15
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 Y12F

<400>  15

Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Phe Pro Thr Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Pro 
            20  


<210>  16
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 Y15F

<400>  16

Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Phe Tyr 
1               5                   10                  15      


Gly Met Asp Pro 
            20  


<210>  17
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 Y16F

<400>  17

Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr Phe 
1               5                   10                  15      


Gly Met Asp Pro 
            20  


<210>  18
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 T14N

<400>  18

Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Asn Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Pro 
            20  


<210>  19
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 T14V

<400>  19

Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Val Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Pro 
            20  


<210>  20
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 T14S

<400>  20

Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Ser Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Pro 
            20  


<210>  21
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 Y4F/D19N

<400>  21

Asp His Ile Phe Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr Tyr 
1               5                   10                  15      


Gly Met Asn Pro 
            20  


<210>  22
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 Y6F/D19N

<400>  22

Asp His Ile Tyr Arg Phe Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr Tyr 
1               5                   10                  15      


Gly Met Asn Pro 
            20  


<210>  23
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 Y9F/D19N

<400>  23

Asp His Ile Tyr Arg Tyr Asp Asp Phe Gly Asp Tyr Pro Thr Tyr Tyr 
1               5                   10                  15      


Gly Met Asn Pro 
            20  


<210>  24
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 Y12F/D19N

<400>  24

Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Phe Pro Thr Tyr Tyr 
1               5                   10                  15      


Gly Met Asn Pro 
            20  


<210>  25
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 Y15F/D19N

<400>  25

Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Phe Tyr 
1               5                   10                  15      


Gly Met Asn Pro 
            20  


<210>  26
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 Y16F/D19N

<400>  26

Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr Phe 
1               5                   10                  15      


Gly Met Asn Pro 
            20  


<210>  27
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 T14N/D19N

<400>  27

Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Asn Tyr Tyr 
1               5                   10                  15      


Gly Met Asn Pro 
            20  


<210>  28
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 T14V/D19N

<400>  28

Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Val Tyr Tyr 
1               5                   10                  15      


Gly Met Asn Pro 
            20  


<210>  29
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 T14S/D19N

<400>  29

Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Ser Tyr Tyr 
1               5                   10                  15      


Gly Met Asn Pro 
            20  


<210>  30
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rabbit VL

<400>  30

Ala Val Val Leu Thr Gln Thr Pro Ser Pro Met Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Gln Ser Val Tyr Asn Asn 
            20                  25                  30          


Asn Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Asp 
                85                  90                  95      


Asp Val Asp Thr Tyr Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


<210>  31
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabbit VL nucl.

<400>  31
gcagtcgtgc tgactcagac accatcaccc atgtctgcag ctgtgggagg cacagtcacc       60

atcagttgcc agtccagtca gagtgtttat aataataacg acttagcctg gtatcagcag      120

aaaccagggc agcctcctaa gctcctgatc tacagggcat ccactctggc atctggggtc      180

ccgtcgcggt tcagcggcag tggatctggg acacagttca ctctcaccat cagcggcgtg      240

cagtgtgacg atgctgccac ttactactgt ctaggcggtt atgatgatga tgttgatacg      300

tatactttcg gcggagggac cgaggtggtg gtcaaa                                336


<210>  32
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rabbit VH

<400>  32

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Gly 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Ala 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp His 
                85                  90                  95      


Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Pro Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  33
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabbit VH nucl.

<400>  33
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcagtagc tatggaatga gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggaattatt agtagtagtg gtagcacata ctacgcgagc      180

tgggcgaaag gccgattcac catctccaag acctcgacca cggtggatct gaaaatcgcc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagatcacat ttataggtac      300

gatgactatg gtgattaccc tacctactac ggcatggacc cctggggccc aggcaccctg      360

gtcaccgtct cgagc                                                       375


<210>  34
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gL2 VL

<400>  34

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Tyr Asn Asn 
            20                  25                  30          


Asn Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Asp 
                85                  90                  95      


Asp Val Asp Thr Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  35
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gL2 VL nucl.

<400>  35
gccattcaac tgactcagtc cccatcctcc ctgtccgcat ccgtggggga tagagtcacc       60

atcacctgtc agtcgagcca gtcagtgtac aacaacaacg acctggcctg gtatcagcag      120

aagccgggaa aggctcccaa gttgctgatc taccgggcct caacgctcgc gtcgggagtg      180

cctagccgct tttccggttc cggatctggc accgacttca ctctcaccat ttcgagcctt      240

caaccggagg acttcgccac ttactactgc ctgggcggtt acgatgacga tgtggacacc      300

tacaccttcg gcggagggac caaagtggaa atcaag                                336


<210>  36
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gL2 Light Chain

<400>  36

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Tyr Asn Asn 
            20                  25                  30          


Asn Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Asp 
                85                  90                  95      


Asp Val Asp Thr Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  37
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gL2 Ligh Chain nucl.

<400>  37
gccattcaac tgactcagtc cccatcctcc ctgtccgcat ccgtggggga tagagtcacc       60

atcacctgtc agtcgagcca gtcagtgtac aacaacaacg acctggcctg gtatcagcag      120

aagccgggaa aggctcccaa gttgctgatc taccgggcct caacgctcgc gtcgggagtg      180

cctagccgct tttccggttc cggatctggc accgacttca ctctcaccat ttcgagcctt      240

caaccggagg acttcgccac ttactactgc ctgggcggtt acgatgacga tgtggacacc      300

tacaccttcg gcggagggac caaagtggaa atcaagcgta cggtggccgc tccctccgtg      360

ttcatcttcc caccctccga cgagcagctg aagtccggca ccgcctccgt cgtgtgcctg      420

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      480

tccggcaact cccaggaatc cgtcaccgag caggactcca aggacagcac ctactccctg      540

tcctccaccc tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccacc agggcctgtc cagccccgtg accaagtcct tcaaccgggg cgagtgc         657


<210>  38
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gL2 VL Q1R

<400>  38

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Val Tyr Asn Asn 
            20                  25                  30          


Asn Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Asp 
                85                  90                  95      


Asp Val Asp Thr Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  39
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gL2 VL Q1R nucl.

<400>  39
gccattcaac tgactcagtc cccatcctcc ctgtccgcat ccgtggggga tagagtcacc       60

atcacctgtc ggtcgagcca gtcagtgtac aacaacaacg acctggcctg gtatcagcag      120

aagccgggaa aggctcccaa gttgctgatc taccgggcct caacgctcgc gtcgggagtg      180

cctagccgct tttccggttc cggatctggc accgacttca ctctcaccat ttcgagcctt      240

caaccggagg acttcgccac ttactactgc ctgggcggtt acgatgacga tgtggacacc      300

tacaccttcg gcggagggac caaagtggaa atcaag                                336


<210>  40
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gL2 Light Chain Q1R

<400>  40

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Val Tyr Asn Asn 
            20                  25                  30          


Asn Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Asp 
                85                  90                  95      


Asp Val Asp Thr Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  41
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gL2 Light Chain Q1R nucl.

<400>  41
gccattcaac tgactcagtc cccatcctcc ctgtccgcat ccgtggggga tagagtcacc       60

atcacctgtc ggtcgagcca gtcagtgtac aacaacaacg acctggcctg gtatcagcag      120

aagccgggaa aggctcccaa gttgctgatc taccgggcct caacgctcgc gtcgggagtg      180

cctagccgct tttccggttc cggatctggc accgacttca ctctcaccat ttcgagcctt      240

caaccggagg acttcgccac ttactactgc ctgggcggtt acgatgacga tgtggacacc      300

tacaccttcg gcggagggac caaagtggaa atcaagcgta cggtggccgc tccctccgtg      360

ttcatcttcc caccctccga cgagcagctg aagtccggca ccgcctccgt cgtgtgcctg      420

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      480

tccggcaact cccaggaatc cgtcaccgag caggactcca aggacagcac ctactccctg      540

tcctccaccc tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccacc agggcctgtc cagccccgtg accaagtcct tcaaccgggg cgagtgc         657


<210>  42
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gL2 VLQ1K

<400>  42

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Val Tyr Asn Asn 
            20                  25                  30          


Asn Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Asp 
                85                  90                  95      


Asp Val Asp Thr Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  43
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gL2 L Q1K nucl.

<400>  43
gccattcaac tgactcagtc cccatcctcc ctgtccgcat ccgtggggga tagagtcacc       60

atcacctgta aatcgagcca gtcagtgtac aacaacaacg acctggcctg gtatcagcag      120

aagccgggaa aggctcccaa gttgctgatc taccgggcct caacgctcgc gtcgggagtg      180

cctagccgct tttccggttc cggatctggc accgacttca ctctcaccat ttcgagcctt      240

caaccggagg acttcgccac ttactactgc ctgggcggtt acgatgacga tgtggacacc      300

tacaccttcg gcggagggac caaagtggaa atcaag                                336


<210>  44
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gL2 Light Chain Q1K

<400>  44

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Val Tyr Asn Asn 
            20                  25                  30          


Asn Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Asp 
                85                  90                  95      


Asp Val Asp Thr Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  45
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gL2 Light Chain Q1K nucl.

<400>  45
gccattcaac tgactcagtc cccatcctcc ctgtccgcat ccgtggggga tagagtcacc       60

atcacctgta aatcgagcca gtcagtgtac aacaacaacg acctggcctg gtatcagcag      120

aagccgggaa aggctcccaa gttgctgatc taccgggcct caacgctcgc gtcgggagtg      180

cctagccgct tttccggttc cggatctggc accgacttca ctctcaccat ttcgagcctt      240

caaccggagg acttcgccac ttactactgc ctgggcggtt acgatgacga tgtggacacc      300

tacaccttcg gcggagggac caaagtggaa atcaagcgta cggtggccgc tccctccgtg      360

ttcatcttcc caccctccga cgagcagctg aagtccggca ccgcctccgt cgtgtgcctg      420

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      480

tccggcaact cccaggaatc cgtcaccgag caggactcca aggacagcac ctactccctg      540

tcctccaccc tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccacc agggcctgtc cagccccgtg accaagtcct tcaaccgggg cgagtgc         657


<210>  46
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gL2 VL Q1H

<400>  46

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ser Ser Gln Ser Val Tyr Asn Asn 
            20                  25                  30          


Asn Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Asp 
                85                  90                  95      


Asp Val Asp Thr Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  47
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gL2 VL Q1H nucl.

<400>  47
gccattcaac tgactcagtc cccatcctcc ctgtccgcat ccgtggggga tagagtcacc       60

atcacctgtc actcgagcca gtcagtgtac aacaacaacg acctggcctg gtatcagcag      120

aagccgggaa aggctcccaa gttgctgatc taccgggcct caacgctcgc gtcgggagtg      180

cctagccgct tttccggttc cggatctggc accgacttca ctctcaccat ttcgagcctt      240

caaccggagg acttcgccac ttactactgc ctgggcggtt acgatgacga tgtggacacc      300

tacaccttcg gcggagggac caaagtggaa atcaag                                336


<210>  48
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1027 gL2 Light Chain Q1H

<400>  48

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ser Ser Gln Ser Val Tyr Asn Asn 
            20                  25                  30          


Asn Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Asp 
                85                  90                  95      


Asp Val Asp Thr Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  49
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gL2 Light Chain Q1H nucl.

<400>  49
gccattcaac tgactcagtc cccatcctcc ctgtccgcat ccgtggggga tagagtcacc       60

atcacctgtc actcgagcca gtcagtgtac aacaacaacg acctggcctg gtatcagcag      120

aagccgggaa aggctcccaa gttgctgatc taccgggcct caacgctcgc gtcgggagtg      180

cctagccgct tttccggttc cggatctggc accgacttca ctctcaccat ttcgagcctt      240

caaccggagg acttcgccac ttactactgc ctgggcggtt acgatgacga tgtggacacc      300

tacaccttcg gcggagggac caaagtggaa atcaagcgta cggtggccgc tccctccgtg      360

ttcatcttcc caccctccga cgagcagctg aagtccggca ccgcctccgt cgtgtgcctg      420

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      480

tccggcaact cccaggaatc cgtcaccgag caggactcca aggacagcac ctactccctg      540

tcctccaccc tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccacc agggcctgtc cagccccgtg accaagtcct tcaaccgggg cgagtgc         657


<210>  50
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH1 VH

<400>  50

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asp Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  51
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH1 VH nucl.

<400>  51
gaagtgcagc tcgtcgaatc cggaggtgga ctggtgcagc caggcggaag cctcaggttg       60

tcctgcgcgg tgtcagggtt cagcctgtcg tcatacggaa tgtcctgggt cagacaggcc      120

cctggcaaag gccttgagtg gattgggatc atctcctcct ccgggtccac ctactacgcc      180

tcttgggcca agggacggtt caccatttcg aaggacagct cgaagaacac cgtgtatctg      240

cagatgaaca gcctgcgggc agaggacacc gctgtgtact actgtgcccg cgatcacatc      300

taccgctatg acgactacgg cgattacccg acttactacg gaatggaccc ctggggtcaa      360

ggcaccactg tgactgtctc gagc                                             384


<210>  52
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH1 Heavy Chain

<400>  52

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asp Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Leu Gly Lys 
    450                 455 


<210>  53
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH1 Heavy chain nucl.

<400>  53
gaagtgcagc tcgtcgaatc cggaggtgga ctggtgcagc caggcggaag cctcaggttg       60

tcctgcgcgg tgtcagggtt cagcctgtcg tcatacggaa tgtcctgggt cagacaggcc      120

cctggcaaag gccttgagtg gattgggatc atctcctcct ccgggtccac ctactacgcc      180

tcttgggcca agggacggtt caccatttcg aaggacagct cgaagaacac cgtgtatctg      240

cagatgaaca gcctgcgggc agaggacacc gctgtgtact actgtgcccg cgatcacatc      300

taccgctatg acgactacgg cgattacccg acttactacg gaatggaccc ctggggtcaa      360

ggcaccactg tgactgtctc gagcgcttct acaaagggcc cctccgtgtt ccctctggcc      420

ccttgctccc ggtccacctc cgagtctacc gccgctctgg gctgcctggt caaggactac      480

ttccccgagc ccgtgacagt gtcctggaac tctggcgccc tgacctccgg cgtgcacacc      540

ttccctgccg tgctgcagtc ctccggcctg tactccctgt cctccgtcgt gaccgtgccc      600

tcctccagcc tgggcaccaa gacctacacc tgtaacgtgg accacaagcc ctccaacacc      660

aaggtggaca agcgggtgga atctaagtac ggccctccct gccccccctg ccctgcccct      720

gaatttctgg gcggaccttc cgtgttcctg ttccccccaa agcccaagga caccctgatg      780

atctcccgga cccccgaagt gacctgcgtg gtggtggacg tgtcccagga agatcccgag      840

gtccagttca attggtacgt ggacggcgtg gaagtgcaca atgccaagac caagcccaga      900

gaggaacagt tcaactccac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggac      960

tggctgaacg gcaaagagta caagtgcaag gtgtccaaca agggcctgcc ctccagcatc     1020

gaaaagacca tctccaaggc caagggccag ccccgcgagc cccaggtgta caccctgccc     1080

cctagccagg aagagatgac caagaaccag gtgtccctga cctgtctggt caagggcttc     1140

tacccctccg acattgccgt ggaatgggag tccaacggcc agcccgagaa caactacaag     1200

accacccccc ctgtgctgga cagcgacggc tccttcttcc tgtactctcg gctgaccgtg     1260

gacaagtccc ggtggcagga aggcaacgtc ttctcctgct ccgtgatgca cgaggccctg     1320

cacaaccact acacccagaa gtccctgtcc ctgagcctgg gcaag                     1365


<210>  54
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH1 VH D19N

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  55
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH1 VH D19N nucl.

<400>  55
gaagtgcagc tcgtcgaatc cggaggtgga ctggtgcagc caggcggaag cctcaggttg       60

tcctgcgcgg tgtcagggtt cagcctgtcg tcatacggaa tgtcctgggt cagacaggcc      120

cctggcaaag gccttgagtg gattgggatc atctcctcct ccgggtccac ctactacgcc      180

tcttgggcca agggacggtt caccatttcg aaggacagct cgaagaacac cgtgtatctg      240

cagatgaaca gcctgcgggc agaggacacc gctgtgtact actgtgcccg cgatcacatc      300

taccgctatg acgactacgg cgattacccg acttactacg gaatgaaccc ctggggtcaa      360

ggcaccactg tgactgtctc gagc                                             384


<210>  56
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH1 Heavy Chain D19N

<400>  56

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Leu Gly Lys 
    450                 455 


<210>  57
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH1 Heavy Chain D19N nucl.

<400>  57
gaagtgcagc tcgtcgaatc cggaggtgga ctggtgcagc caggcggaag cctcaggttg       60

tcctgcgcgg tgtcagggtt cagcctgtcg tcatacggaa tgtcctgggt cagacaggcc      120

cctggcaaag gccttgagtg gattgggatc atctcctcct ccgggtccac ctactacgcc      180

tcttgggcca agggacggtt caccatttcg aaggacagct cgaagaacac cgtgtatctg      240

cagatgaaca gcctgcgggc agaggacacc gctgtgtact actgtgcccg cgatcacatc      300

taccgctatg acgactacgg cgattacccg acttactacg gaatgaaccc ctggggtcaa      360

ggcaccactg tgactgtctc gagcgcttct acaaagggcc cctccgtgtt ccctctggcc      420

ccttgctccc ggtccacctc cgagtctacc gccgctctgg gctgcctggt caaggactac      480

ttccccgagc ccgtgacagt gtcctggaac tctggcgccc tgacctccgg cgtgcacacc      540

ttccctgccg tgctgcagtc ctccggcctg tactccctgt cctccgtcgt gaccgtgccc      600

tcctccagcc tgggcaccaa gacctacacc tgtaacgtgg accacaagcc ctccaacacc      660

aaggtggaca agcgggtgga atctaagtac ggccctccct gccccccctg ccctgcccct      720

gaatttctgg gcggaccttc cgtgttcctg ttccccccaa agcccaagga caccctgatg      780

atctcccgga cccccgaagt gacctgcgtg gtggtggacg tgtcccagga agatcccgag      840

gtccagttca attggtacgt ggacggcgtg gaagtgcaca atgccaagac caagcccaga      900

gaggaacagt tcaactccac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggac      960

tggctgaacg gcaaagagta caagtgcaag gtgtccaaca agggcctgcc ctccagcatc     1020

gaaaagacca tctccaaggc caagggccag ccccgcgagc cccaggtgta caccctgccc     1080

cctagccagg aagagatgac caagaaccag gtgtccctga cctgtctggt caagggcttc     1140

tacccctccg acattgccgt ggaatgggag tccaacggcc agcccgagaa caactacaag     1200

accacccccc ctgtgctgga cagcgacggc tccttcttcc tgtactctcg gctgaccgtg     1260

gacaagtccc ggtggcagga aggcaacgtc ttctcctgct ccgtgatgca cgaggccctg     1320

cacaaccact acacccagaa gtccctgtcc ctgagcctgg gcaag                     1365


<210>  58
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH1 VH D19E

<400>  58

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Glu Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  59
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH1 VH D19E nucl.

<400>  59
gaagtgcagc tcgtcgaatc cggaggtgga ctggtgcagc caggcggaag cctcaggttg       60

tcctgcgcgg tgtcagggtt cagcctgtcg tcatacggaa tgtcctgggt cagacaggcc      120

cctggcaaag gccttgagtg gattgggatc atctcctcct ccgggtccac ctactacgcc      180

tcttgggcca agggacggtt caccatttcg aaggacagct cgaagaacac cgtgtatctg      240

cagatgaaca gcctgcgggc agaggacacc gctgtgtact actgtgcccg cgatcacatc      300

taccgctatg acgactacgg cgattacccg acttactacg gaatggagcc ctggggtcaa      360

ggcaccactg tgactgtctc gagc                                             384


<210>  60
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH1 Heavy Chain D19E

<400>  60

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Glu Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Leu Gly Lys 
    450                 455 


<210>  61
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH1 Heavy Chain D19E nucl.

<400>  61
gaagtgcagc tcgtcgaatc cggaggtgga ctggtgcagc caggcggaag cctcaggttg       60

tcctgcgcgg tgtcagggtt cagcctgtcg tcatacggaa tgtcctgggt cagacaggcc      120

cctggcaaag gccttgagtg gattgggatc atctcctcct ccgggtccac ctactacgcc      180

tcttgggcca agggacggtt caccatttcg aaggacagct cgaagaacac cgtgtatctg      240

cagatgaaca gcctgcgggc agaggacacc gctgtgtact actgtgcccg cgatcacatc      300

taccgctatg acgactacgg cgattacccg acttactacg gaatggagcc ctggggtcaa      360

ggcaccactg tgactgtctc gagcgcttct acaaagggcc cctccgtgtt ccctctggcc      420

ccttgctccc ggtccacctc cgagtctacc gccgctctgg gctgcctggt caaggactac      480

ttccccgagc ccgtgacagt gtcctggaac tctggcgccc tgacctccgg cgtgcacacc      540

ttccctgccg tgctgcagtc ctccggcctg tactccctgt cctccgtcgt gaccgtgccc      600

tcctccagcc tgggcaccaa gacctacacc tgtaacgtgg accacaagcc ctccaacacc      660

aaggtggaca agcgggtgga atctaagtac ggccctccct gccccccctg ccctgcccct      720

gaatttctgg gcggaccttc cgtgttcctg ttccccccaa agcccaagga caccctgatg      780

atctcccgga cccccgaagt gacctgcgtg gtggtggacg tgtcccagga agatcccgag      840

gtccagttca attggtacgt ggacggcgtg gaagtgcaca atgccaagac caagcccaga      900

gaggaacagt tcaactccac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggac      960

tggctgaacg gcaaagagta caagtgcaag gtgtccaaca agggcctgcc ctccagcatc     1020

gaaaagacca tctccaaggc caagggccag ccccgcgagc cccaggtgta caccctgccc     1080

cctagccagg aagagatgac caagaaccag gtgtccctga cctgtctggt caagggcttc     1140

tacccctccg acattgccgt ggaatgggag tccaacggcc agcccgagaa caactacaag     1200

accacccccc ctgtgctgga cagcgacggc tccttcttcc tgtactctcg gctgaccgtg     1260

gacaagtccc ggtggcagga aggcaacgtc ttctcctgct ccgtgatgca cgaggccctg     1320

cacaaccact acacccagaa gtccctgtcc ctgagcctgg gcaag                     1365


<210>  62
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH4 VH

<400>  62

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asp Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  63
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH4 VH nucl.

<400>  63
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg cctccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc aaggacagct ccaagaacac tgtgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctatg atgactacgg ggactacccg acctactacg gaatggaccc ttggggacag      360

ggcaccactg tgactgtctc gagc                                             384


<210>  64
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH4 Heavy Chain

<400>  64

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asp Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Leu Gly Lys 
    450                 455 


<210>  65
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH4 Heavy Chain nucl.

<400>  65
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg cctccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc aaggacagct ccaagaacac tgtgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctatg atgactacgg ggactacccg acctactacg gaatggaccc ttggggacag      360

ggcaccactg tgactgtctc gagcgcttct acaaagggcc cctccgtgtt ccctctggcc      420

ccttgctccc ggtccacctc cgagtctacc gccgctctgg gctgcctggt caaggactac      480

ttccccgagc ccgtgacagt gtcctggaac tctggcgccc tgacctccgg cgtgcacacc      540

ttccctgccg tgctgcagtc ctccggcctg tactccctgt cctccgtcgt gaccgtgccc      600

tcctccagcc tgggcaccaa gacctacacc tgtaacgtgg accacaagcc ctccaacacc      660

aaggtggaca agcgggtgga atctaagtac ggccctccct gccccccctg ccctgcccct      720

gaatttctgg gcggaccttc cgtgttcctg ttccccccaa agcccaagga caccctgatg      780

atctcccgga cccccgaagt gacctgcgtg gtggtggacg tgtcccagga agatcccgag      840

gtccagttca attggtacgt ggacggcgtg gaagtgcaca atgccaagac caagcccaga      900

gaggaacagt tcaactccac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggac      960

tggctgaacg gcaaagagta caagtgcaag gtgtccaaca agggcctgcc ctccagcatc     1020

gaaaagacca tctccaaggc caagggccag ccccgcgagc cccaggtgta caccctgccc     1080

cctagccagg aagagatgac caagaaccag gtgtccctga cctgtctggt caagggcttc     1140

tacccctccg acattgccgt ggaatgggag tccaacggcc agcccgagaa caactacaag     1200

accacccccc ctgtgctgga cagcgacggc tccttcttcc tgtactctcg gctgaccgtg     1260

gacaagtccc ggtggcagga aggcaacgtc ttctcctgct ccgtgatgca cgaggccctg     1320

cacaaccact acacccagaa gtccctgtcc ctgagcctgg gcaag                     1365


<210>  66
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH4 VH D19N

<400>  66

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  67
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH4 VH D19N nucl.

<400>  67
gaagtgcagc tcgtcgaatc cggaggtgga ctggtgcagc caggcggaag cctcaggttg       60

tcctgcgcgg cttcagggtt cagcctgtcg tcatacggaa tgtcctgggt cagacaggcc      120

cctggcaaag gccttgagtg gattgggatc atctcctcct ccgggtccac ctactacgcc      180

tcttgggcca agggacggtt caccatttcg aaggacagct cgaagaacac cgtgtatctg      240

cagatgaaca gcctgcgggc agaggacacc gctgtgtact actgtgcccg cgatcacatc      300

taccgctatg acgactacgg cgattacccg acttactacg gaatgaaccc ctggggtcaa      360

ggcaccactg tgactgtctc gagc                                             384


<210>  68
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH4 Heavy Chain D19N

<400>  68

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Leu Gly Lys 
    450                 455 


<210>  69
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH4 Heavy Chain D19N nucl.

<400>  69
gaagtgcagc tcgtcgaatc cggaggtgga ctggtgcagc caggcggaag cctcaggttg       60

tcctgcgcgg cttcagggtt cagcctgtcg tcatacggaa tgtcctgggt cagacaggcc      120

cctggcaaag gccttgagtg gattgggatc atctcctcct ccgggtccac ctactacgcc      180

tcttgggcca agggacggtt caccatttcg aaggacagct cgaagaacac cgtgtatctg      240

cagatgaaca gcctgcgggc agaggacacc gctgtgtact actgtgcccg cgatcacatc      300

taccgctatg acgactacgg cgattacccg acttactacg gaatgaaccc ctggggtcaa      360

ggcaccactg tgactgtctc gagcgcttct acaaagggcc cctccgtgtt ccctctggcc      420

ccttgctccc ggtccacctc cgagtctacc gccgctctgg gctgcctggt caaggactac      480

ttccccgagc ccgtgacagt gtcctggaac tctggcgccc tgacctccgg cgtgcacacc      540

ttccctgccg tgctgcagtc ctccggcctg tactccctgt cctccgtcgt gaccgtgccc      600

tcctccagcc tgggcaccaa gacctacacc tgtaacgtgg accacaagcc ctccaacacc      660

aaggtggaca agcgggtgga atctaagtac ggccctccct gccccccctg ccctgcccct      720

gaatttctgg gcggaccttc cgtgttcctg ttccccccaa agcccaagga caccctgatg      780

atctcccgga cccccgaagt gacctgcgtg gtggtggacg tgtcccagga agatcccgag      840

gtccagttca attggtacgt ggacggcgtg gaagtgcaca atgccaagac caagcccaga      900

gaggaacagt tcaactccac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggac      960

tggctgaacg gcaaagagta caagtgcaag gtgtccaaca agggcctgcc ctccagcatc     1020

gaaaagacca tctccaaggc caagggccag ccccgcgagc cccaggtgta caccctgccc     1080

cctagccagg aagagatgac caagaaccag gtgtccctga cctgtctggt caagggcttc     1140

tacccctccg acattgccgt ggaatgggag tccaacggcc agcccgagaa caactacaag     1200

accacccccc ctgtgctgga cagcgacggc tccttcttcc tgtactctcg gctgaccgtg     1260

gacaagtccc ggtggcagga aggcaacgtc ttctcctgct ccgtgatgca cgaggccctg     1320

cacaaccact acacccagaa gtccctgtcc ctgagcctgg gcaag                     1365


<210>  70
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH5 VH

<400>  70

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asp Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  71
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH5 VH nucl.

<400>  71
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg ggtcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc aaggacagct ccaagaacac tgtgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctatg atgactacgg ggactacccg acctactacg gaatggaccc ttggggacag      360

ggcaccactg tgactgtctc gagc                                             384


<210>  72
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH5 Heavy Chain

<400>  72

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asp Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Leu Gly Lys 
    450                 455 


<210>  73
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH5 Heavy Chain nucl.

<400>  73
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg ggtcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc aaggacagct ccaagaacac tgtgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctatg atgactacgg ggactacccg acctactacg gaatggaccc ttggggacag      360

ggcaccactg tgactgtctc gagcgcttct acaaagggcc cctccgtgtt ccctctggcc      420

ccttgctccc ggtccacctc cgagtctacc gccgctctgg gctgcctggt caaggactac      480

ttccccgagc ccgtgacagt gtcctggaac tctggcgccc tgacctccgg cgtgcacacc      540

ttccctgccg tgctgcagtc ctccggcctg tactccctgt cctccgtcgt gaccgtgccc      600

tcctccagcc tgggcaccaa gacctacacc tgtaacgtgg accacaagcc ctccaacacc      660

aaggtggaca agcgggtgga atctaagtac ggccctccct gccccccctg ccctgcccct      720

gaatttctgg gcggaccttc cgtgttcctg ttccccccaa agcccaagga caccctgatg      780

atctcccgga cccccgaagt gacctgcgtg gtggtggacg tgtcccagga agatcccgag      840

gtccagttca attggtacgt ggacggcgtg gaagtgcaca atgccaagac caagcccaga      900

gaggaacagt tcaactccac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggac      960

tggctgaacg gcaaagagta caagtgcaag gtgtccaaca agggcctgcc ctccagcatc     1020

gaaaagacca tctccaaggc caagggccag ccccgcgagc cccaggtgta caccctgccc     1080

cctagccagg aagagatgac caagaaccag gtgtccctga cctgtctggt caagggcttc     1140

tacccctccg acattgccgt ggaatgggag tccaacggcc agcccgagaa caactacaag     1200

accacccccc ctgtgctgga cagcgacggc tccttcttcc tgtactctcg gctgaccgtg     1260

gacaagtccc ggtggcagga aggcaacgtc ttctcctgct ccgtgatgca cgaggccctg     1320

cacaaccact acacccagaa gtccctgtcc ctgagcctgg gcaag                     1365


<210>  74
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH5 VH D19N

<400>  74

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  75
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH5 VH D19N nucl.

<400>  75
gaagtgcagc tcgtcgaatc cggaggtgga ctggtgcagc caggcggaag cctcaggttg       60

tcctgcgcgg tgtcagggtt cagcctgtcg tcatacggaa tgtcctgggt cagacaggcc      120

cctggcaaag gccttgagtg ggtcgggatc atctcctcct ccgggtccac ctactacgcc      180

tcttgggcca agggacggtt caccatttcg aaggacagct cgaagaacac cgtgtatctg      240

cagatgaaca gcctgcgggc agaggacacc gctgtgtact actgtgcccg cgatcacatc      300

taccgctatg acgactacgg cgattacccg acttactacg gaatgaaccc ctggggtcaa      360

ggcaccactg tgactgtctc gagc                                             384


<210>  76
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH5 Heavy Chain D19N

<400>  76

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Leu Gly Lys 
    450                 455 


<210>  77
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH5 Heavy Chain D19N nucl.

<400>  77
gaagtgcagc tcgtcgaatc cggaggtgga ctggtgcagc caggcggaag cctcaggttg       60

tcctgcgcgg tgtcagggtt cagcctgtcg tcatacggaa tgtcctgggt cagacaggcc      120

cctggcaaag gccttgagtg ggtcgggatc atctcctcct ccgggtccac ctactacgcc      180

tcttgggcca agggacggtt caccatttcg aaggacagct cgaagaacac cgtgtatctg      240

cagatgaaca gcctgcgggc agaggacacc gctgtgtact actgtgcccg cgatcacatc      300

taccgctatg acgactacgg cgattacccg acttactacg gaatgaaccc ctggggtcaa      360

ggcaccactg tgactgtctc gagcgcttct acaaagggcc cctccgtgtt ccctctggcc      420

ccttgctccc ggtccacctc cgagtctacc gccgctctgg gctgcctggt caaggactac      480

ttccccgagc ccgtgacagt gtcctggaac tctggcgccc tgacctccgg cgtgcacacc      540

ttccctgccg tgctgcagtc ctccggcctg tactccctgt cctccgtcgt gaccgtgccc      600

tcctccagcc tgggcaccaa gacctacacc tgtaacgtgg accacaagcc ctccaacacc      660

aaggtggaca agcgggtgga atctaagtac ggccctccct gccccccctg ccctgcccct      720

gaatttctgg gcggaccttc cgtgttcctg ttccccccaa agcccaagga caccctgatg      780

atctcccgga cccccgaagt gacctgcgtg gtggtggacg tgtcccagga agatcccgag      840

gtccagttca attggtacgt ggacggcgtg gaagtgcaca atgccaagac caagcccaga      900

gaggaacagt tcaactccac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggac      960

tggctgaacg gcaaagagta caagtgcaag gtgtccaaca agggcctgcc ctccagcatc     1020

gaaaagacca tctccaaggc caagggccag ccccgcgagc cccaggtgta caccctgccc     1080

cctagccagg aagagatgac caagaaccag gtgtccctga cctgtctggt caagggcttc     1140

tacccctccg acattgccgt ggaatgggag tccaacggcc agcccgagaa caactacaag     1200

accacccccc ctgtgctgga cagcgacggc tccttcttcc tgtactctcg gctgaccgtg     1260

gacaagtccc ggtggcagga aggcaacgtc ttctcctgct ccgtgatgca cgaggccctg     1320

cacaaccact acacccagaa gtccctgtcc ctgagcctgg gcaag                     1365


<210>  78
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH8 VH

<400>  78

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asp Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  79
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH8 VH nucl.

<400>  79
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc cgggacagct ccaagaacac tgtgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctatg atgactacgg ggactacccg acctactacg gaatggaccc ttggggacag      360

ggcaccactg tgactgtctc gagc                                             384


<210>  80
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH8 Heavy Chain

<400>  80

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asp Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Leu Gly Lys 
    450                 455 


<210>  81
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH8 Heavy Chain nucl.

<400>  81
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc cgggacagct ccaagaacac tgtgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctatg atgactacgg ggactacccg acctactacg gaatggaccc ttggggacag      360

ggcaccactg tgactgtctc gagcgcttct acaaagggcc cctccgtgtt ccctctggcc      420

ccttgctccc ggtccacctc cgagtctacc gccgctctgg gctgcctggt caaggactac      480

ttccccgagc ccgtgacagt gtcctggaac tctggcgccc tgacctccgg cgtgcacacc      540

ttccctgccg tgctgcagtc ctccggcctg tactccctgt cctccgtcgt gaccgtgccc      600

tcctccagcc tgggcaccaa gacctacacc tgtaacgtgg accacaagcc ctccaacacc      660

aaggtggaca agcgggtgga atctaagtac ggccctccct gccccccctg ccctgcccct      720

gaatttctgg gcggaccttc cgtgttcctg ttccccccaa agcccaagga caccctgatg      780

atctcccgga cccccgaagt gacctgcgtg gtggtggacg tgtcccagga agatcccgag      840

gtccagttca attggtacgt ggacggcgtg gaagtgcaca atgccaagac caagcccaga      900

gaggaacagt tcaactccac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggac      960

tggctgaacg gcaaagagta caagtgcaag gtgtccaaca agggcctgcc ctccagcatc     1020

gaaaagacca tctccaaggc caagggccag ccccgcgagc cccaggtgta caccctgccc     1080

cctagccagg aagagatgac caagaaccag gtgtccctga cctgtctggt caagggcttc     1140

tacccctccg acattgccgt ggaatgggag tccaacggcc agcccgagaa caactacaag     1200

accacccccc ctgtgctgga cagcgacggc tccttcttcc tgtactctcg gctgaccgtg     1260

gacaagtccc ggtggcagga aggcaacgtc ttctcctgct ccgtgatgca cgaggccctg     1320

cacaaccact acacccagaa gtccctgtcc ctgagcctgg gcaag                     1365


<210>  82
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH VH D19N

<400>  82

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  83
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH8 VH D19N nucl.

<400>  83
gaagtgcagc tcgtcgaatc cggaggtgga ctggtgcagc caggcggaag cctcaggttg       60

tcctgcgcgg tgtcagggtt cagcctgtcg tcatacggaa tgtcctgggt cagacaggcc      120

cctggcaaag gccttgagtg gattgggatc atctcctcct ccgggtccac ctactacgcc      180

tcttgggcca agggacggtt caccatttcg cgggacagct cgaagaacac cgtgtatctg      240

cagatgaaca gcctgcgggc agaggacacc gctgtgtact actgtgcccg cgatcacatc      300

taccgctatg acgactacgg cgattacccg acttactacg gaatgaaccc ctggggtcaa      360

ggcaccactg tgactgtctc gagc                                             384


<210>  84
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH8 Heavy Chain D19N

<400>  84

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Leu Gly Lys 
    450                 455 


<210>  85
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH Heavy Chain D19N nucl.

<400>  85
gaagtgcagc tcgtcgaatc cggaggtgga ctggtgcagc caggcggaag cctcaggttg       60

tcctgcgcgg tgtcagggtt cagcctgtcg tcatacggaa tgtcctgggt cagacaggcc      120

cctggcaaag gccttgagtg gattgggatc atctcctcct ccgggtccac ctactacgcc      180

tcttgggcca agggacggtt caccatttcg cgggacagct cgaagaacac cgtgtatctg      240

cagatgaaca gcctgcgggc agaggacacc gctgtgtact actgtgcccg cgatcacatc      300

taccgctatg acgactacgg cgattacccg acttactacg gaatgaaccc ctggggtcaa      360

ggcaccactg tgactgtctc gagcgcttct acaaagggcc cctccgtgtt ccctctggcc      420

ccttgctccc ggtccacctc cgagtctacc gccgctctgg gctgcctggt caaggactac      480

ttccccgagc ccgtgacagt gtcctggaac tctggcgccc tgacctccgg cgtgcacacc      540

ttccctgccg tgctgcagtc ctccggcctg tactccctgt cctccgtcgt gaccgtgccc      600

tcctccagcc tgggcaccaa gacctacacc tgtaacgtgg accacaagcc ctccaacacc      660

aaggtggaca agcgggtgga atctaagtac ggccctccct gccccccctg ccctgcccct      720

gaatttctgg gcggaccttc cgtgttcctg ttccccccaa agcccaagga caccctgatg      780

atctcccgga cccccgaagt gacctgcgtg gtggtggacg tgtcccagga agatcccgag      840

gtccagttca attggtacgt ggacggcgtg gaagtgcaca atgccaagac caagcccaga      900

gaggaacagt tcaactccac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggac      960

tggctgaacg gcaaagagta caagtgcaag gtgtccaaca agggcctgcc ctccagcatc     1020

gaaaagacca tctccaaggc caagggccag ccccgcgagc cccaggtgta caccctgccc     1080

cctagccagg aagagatgac caagaaccag gtgtccctga cctgtctggt caagggcttc     1140

tacccctccg acattgccgt ggaatgggag tccaacggcc agcccgagaa caactacaag     1200

accacccccc ctgtgctgga cagcgacggc tccttcttcc tgtactctcg gctgaccgtg     1260

gacaagtccc ggtggcagga aggcaacgtc ttctcctgct ccgtgatgca cgaggccctg     1320

cacaaccact acacccagaa gtccctgtcc ctgagcctgg gcaag                     1365


<210>  86
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH10 VH nucl.

<400>  86

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asp Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  87
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH10 VH nucl.

<400>  87
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc aaggacagct ccaagaacac tttgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctatg atgactacgg ggactacccg acctactacg gaatggaccc ttggggacag      360

ggcaccactg tgactgtctc gagc                                             384


<210>  88
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH10 Heavy Chain

<400>  88

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asp Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Leu Gly Lys 
    450                 455 


<210>  89
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH10 Hevy Chain nucl.

<400>  89
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc aaggacagct ccaagaacac tttgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctatg atgactacgg ggactacccg acctactacg gaatggaccc ttggggacag      360

ggcaccactg tgactgtctc gagcgcttct acaaagggcc cctccgtgtt ccctctggcc      420

ccttgctccc ggtccacctc cgagtctacc gccgctctgg gctgcctggt caaggactac      480

ttccccgagc ccgtgacagt gtcctggaac tctggcgccc tgacctccgg cgtgcacacc      540

ttccctgccg tgctgcagtc ctccggcctg tactccctgt cctccgtcgt gaccgtgccc      600

tcctccagcc tgggcaccaa gacctacacc tgtaacgtgg accacaagcc ctccaacacc      660

aaggtggaca agcgggtgga atctaagtac ggccctccct gccccccctg ccctgcccct      720

gaatttctgg gcggaccttc cgtgttcctg ttccccccaa agcccaagga caccctgatg      780

atctcccgga cccccgaagt gacctgcgtg gtggtggacg tgtcccagga agatcccgag      840

gtccagttca attggtacgt ggacggcgtg gaagtgcaca atgccaagac caagcccaga      900

gaggaacagt tcaactccac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggac      960

tggctgaacg gcaaagagta caagtgcaag gtgtccaaca agggcctgcc ctccagcatc     1020

gaaaagacca tctccaaggc caagggccag ccccgcgagc cccaggtgta caccctgccc     1080

cctagccagg aagagatgac caagaaccag gtgtccctga cctgtctggt caagggcttc     1140

tacccctccg acattgccgt ggaatgggag tccaacggcc agcccgagaa caactacaag     1200

accacccccc ctgtgctgga cagcgacggc tccttcttcc tgtactctcg gctgaccgtg     1260

gacaagtccc ggtggcagga aggcaacgtc ttctcctgct ccgtgatgca cgaggccctg     1320

cacaaccact acacccagaa gtccctgtcc ctgagcctgg gcaag                     1365


<210>  90
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH10 VH D19N

<400>  90

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  91
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH10 VH D19N nucl.

<400>  91
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc aaggacagct ccaagaacac tttgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctatg atgactacgg ggactacccg acctactacg gaatgaaccc ttggggacag      360

ggcaccactg tgactgtctc gagc                                             384


<210>  92
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH10 Heavy Chain D19N

<400>  92

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Leu Gly Lys 
    450                 455 


<210>  93
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH10 Heavy Chain D19N nucl.

<400>  93
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc aaggacagct ccaagaacac tttgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctatg atgactacgg ggactacccg acctactacg gaatgaaccc ttggggacag      360

ggcaccactg tgactgtctc gagcgcttct acaaagggcc cctccgtgtt ccctctggcc      420

ccttgctccc ggtccacctc cgagtctacc gccgctctgg gctgcctggt caaggactac      480

ttccccgagc ccgtgacagt gtcctggaac tctggcgccc tgacctccgg cgtgcacacc      540

ttccctgccg tgctgcagtc ctccggcctg tactccctgt cctccgtcgt gaccgtgccc      600

tcctccagcc tgggcaccaa gacctacacc tgtaacgtgg accacaagcc ctccaacacc      660

aaggtggaca agcgggtgga atctaagtac ggccctccct gccccccctg ccctgcccct      720

gaatttctgg gcggaccttc cgtgttcctg ttccccccaa agcccaagga caccctgatg      780

atctcccgga cccccgaagt gacctgcgtg gtggtggacg tgtcccagga agatcccgag      840

gtccagttca attggtacgt ggacggcgtg gaagtgcaca atgccaagac caagcccaga      900

gaggaacagt tcaactccac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggac      960

tggctgaacg gcaaagagta caagtgcaag gtgtccaaca agggcctgcc ctccagcatc     1020

gaaaagacca tctccaaggc caagggccag ccccgcgagc cccaggtgta caccctgccc     1080

cctagccagg aagagatgac caagaaccag gtgtccctga cctgtctggt caagggcttc     1140

tacccctccg acattgccgt ggaatgggag tccaacggcc agcccgagaa caactacaag     1200

accacccccc ctgtgctgga cagcgacggc tccttcttcc tgtactctcg gctgaccgtg     1260

gacaagtccc ggtggcagga aggcaacgtc ttctcctgct ccgtgatgca cgaggccctg     1320

cacaaccact acacccagaa gtccctgtcc ctgagcctgg gcaag                     1365


<210>  94
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH11 VH

<400>  94

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asp Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  95
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH11 VH nucl.

<400>  95
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc cgggacaact ccaagaacac tgtgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctatg atgactacgg ggactacccg acctactacg gaatggaccc ttggggacag      360

ggcaccactg tgactgtctc gagc                                             384


<210>  96
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH11 Heavy Chain

<400>  96

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asp Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Leu Gly Lys 
    450                 455 


<210>  97
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH11 Heavy Chain nucl.

<400>  97
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc cgggacaact ccaagaacac tgtgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctatg atgactacgg ggactacccg acctactacg gaatggaccc ttggggacag      360

ggcaccactg tgactgtctc gagcgcttct acaaagggcc cctccgtgtt ccctctggcc      420

ccttgctccc ggtccacctc cgagtctacc gccgctctgg gctgcctggt caaggactac      480

ttccccgagc ccgtgacagt gtcctggaac tctggcgccc tgacctccgg cgtgcacacc      540

ttccctgccg tgctgcagtc ctccggcctg tactccctgt cctccgtcgt gaccgtgccc      600

tcctccagcc tgggcaccaa gacctacacc tgtaacgtgg accacaagcc ctccaacacc      660

aaggtggaca agcgggtgga atctaagtac ggccctccct gccccccctg ccctgcccct      720

gaatttctgg gcggaccttc cgtgttcctg ttccccccaa agcccaagga caccctgatg      780

atctcccgga cccccgaagt gacctgcgtg gtggtggacg tgtcccagga agatcccgag      840

gtccagttca attggtacgt ggacggcgtg gaagtgcaca atgccaagac caagcccaga      900

gaggaacagt tcaactccac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggac      960

tggctgaacg gcaaagagta caagtgcaag gtgtccaaca agggcctgcc ctccagcatc     1020

gaaaagacca tctccaaggc caagggccag ccccgcgagc cccaggtgta caccctgccc     1080

cctagccagg aagagatgac caagaaccag gtgtccctga cctgtctggt caagggcttc     1140

tacccctccg acattgccgt ggaatgggag tccaacggcc agcccgagaa caactacaag     1200

accacccccc ctgtgctgga cagcgacggc tccttcttcc tgtactctcg gctgaccgtg     1260

gacaagtccc ggtggcagga aggcaacgtc ttctcctgct ccgtgatgca cgaggccctg     1320

cacaaccact acacccagaa gtccctgtcc ctgagcctgg gcaag                     1365


<210>  98
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH11 VH D19N

<400>  98

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  99
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH11 VH D19N nucl.

<400>  99
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc cgggacaact ccaagaacac tgtgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctatg atgactacgg ggactacccg acctactacg gaatgaaccc ttggggacag      360

ggcaccactg tgactgtctc gagc                                             384


<210>  100
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH 11 Heavy Chain D19N

<400>  100

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Leu Gly Lys 
    450                 455 


<210>  101
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH11 Heavy Chain D19N nucl.

<400>  101
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc cgggacaact ccaagaacac tgtgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctatg atgactacgg ggactacccg acctactacg gaatgaaccc ttggggacag      360

ggcaccactg tgactgtctc gagcgcttct acaaagggcc cctccgtgtt ccctctggcc      420

ccttgctccc ggtccacctc cgagtctacc gccgctctgg gctgcctggt caaggactac      480

ttccccgagc ccgtgacagt gtcctggaac tctggcgccc tgacctccgg cgtgcacacc      540

ttccctgccg tgctgcagtc ctccggcctg tactccctgt cctccgtcgt gaccgtgccc      600

tcctccagcc tgggcaccaa gacctacacc tgtaacgtgg accacaagcc ctccaacacc      660

aaggtggaca agcgggtgga atctaagtac ggccctccct gccccccctg ccctgcccct      720

gaatttctgg gcggaccttc cgtgttcctg ttccccccaa agcccaagga caccctgatg      780

atctcccgga cccccgaagt gacctgcgtg gtggtggacg tgtcccagga agatcccgag      840

gtccagttca attggtacgt ggacggcgtg gaagtgcaca atgccaagac caagcccaga      900

gaggaacagt tcaactccac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggac      960

tggctgaacg gcaaagagta caagtgcaag gtgtccaaca agggcctgcc ctccagcatc     1020

gaaaagacca tctccaaggc caagggccag ccccgcgagc cccaggtgta caccctgccc     1080

cctagccagg aagagatgac caagaaccag gtgtccctga cctgtctggt caagggcttc     1140

tacccctccg acattgccgt ggaatgggag tccaacggcc agcccgagaa caactacaag     1200

accacccccc ctgtgctgga cagcgacggc tccttcttcc tgtactctcg gctgaccgtg     1260

gacaagtccc ggtggcagga aggcaacgtc ttctcctgct ccgtgatgca cgaggccctg     1320

cacaaccact acacccagaa gtccctgtcc ctgagcctgg gcaag                     1365


<210>  102
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH1 VH Y4F D19N

<400>  102

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Phe Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  103
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH1 VH Y4F D19N nucl.

<400>  103
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc aaggacagct ccaagaacac tgtgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

ttccgctatg atgactacgg ggactacccg acctactacg gaatgaaccc ttggggacag      360

ggcaccactg tgactgtctc gagc                                             384


<210>  104
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH1 Heavy Chain Y4F D19N

<400>  104

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Phe Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Leu Gly Lys 
    450                 455 


<210>  105
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH1 Heavy Chain Y4F D19N nucl.

<400>  105
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc aaggacagct ccaagaacac tgtgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

ttccgctatg atgactacgg ggactacccg acctactacg gaatgaaccc ttggggacag      360

ggcaccactg tgactgtctc gagcgcttct acaaagggcc cctccgtgtt ccctctggcc      420

ccttgctccc ggtccacctc cgagtctacc gccgctctgg gctgcctggt caaggactac      480

ttccccgagc ccgtgacagt gtcctggaac tctggcgccc tgacctccgg cgtgcacacc      540

ttccctgccg tgctgcagtc ctccggcctg tactccctgt cctccgtcgt gaccgtgccc      600

tcctccagcc tgggcaccaa gacctacacc tgtaacgtgg accacaagcc ctccaacacc      660

aaggtggaca agcgggtgga atctaagtac ggccctccct gccccccctg ccctgcccct      720

gaatttctgg gcggaccttc cgtgttcctg ttccccccaa agcccaagga caccctgatg      780

atctcccgga cccccgaagt gacctgcgtg gtggtggacg tgtcccagga agatcccgag      840

gtccagttca attggtacgt ggacggcgtg gaagtgcaca atgccaagac caagcccaga      900

gaggaacagt tcaactccac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggac      960

tggctgaacg gcaaagagta caagtgcaag gtgtccaaca agggcctgcc ctccagcatc     1020

gaaaagacca tctccaaggc caagggccag ccccgcgagc cccaggtgta caccctgccc     1080

cctagccagg aagagatgac caagaaccag gtgtccctga cctgtctggt caagggcttc     1140

tacccctccg acattgccgt ggaatgggag tccaacggcc agcccgagaa caactacaag     1200

accacccccc ctgtgctgga cagcgacggc tccttcttcc tgtactctcg gctgaccgtg     1260

gacaagtccc ggtggcagga aggcaacgtc ttctcctgct ccgtgatgca cgaggccctg     1320

cacaaccact acacccagaa gtccctgtcc ctgagcctgg gcaag                     1365


<210>  106
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH1 VH Y6F D19N

<400>  106

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Phe Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  107
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH1 VH Y6F D19N nucl.

<400>  107
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc aaggacagct ccaagaacac tgtgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctttg atgactacgg ggactacccg acctactacg gaatgaaccc ttggggacag      360

ggcaccactg tgactgtctc gagc                                             384


<210>  108
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH1 Heavy Chain Y6F D19N

<400>  108

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Phe Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Leu Gly Lys 
    450                 455 


<210>  109
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH1 Heavy Chain  Y6F D19N nucl.

<400>  109
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc aaggacagct ccaagaacac tgtgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctttg atgactacgg ggactacccg acctactacg gaatgaaccc ttggggacag      360

ggcaccactg tgactgtctc gagcgcttct acaaagggcc cctccgtgtt ccctctggcc      420

ccttgctccc ggtccacctc cgagtctacc gccgctctgg gctgcctggt caaggactac      480

ttccccgagc ccgtgacagt gtcctggaac tctggcgccc tgacctccgg cgtgcacacc      540

ttccctgccg tgctgcagtc ctccggcctg tactccctgt cctccgtcgt gaccgtgccc      600

tcctccagcc tgggcaccaa gacctacacc tgtaacgtgg accacaagcc ctccaacacc      660

aaggtggaca agcgggtgga atctaagtac ggccctccct gccccccctg ccctgcccct      720

gaatttctgg gcggaccttc cgtgttcctg ttccccccaa agcccaagga caccctgatg      780

atctcccgga cccccgaagt gacctgcgtg gtggtggacg tgtcccagga agatcccgag      840

gtccagttca attggtacgt ggacggcgtg gaagtgcaca atgccaagac caagcccaga      900

gaggaacagt tcaactccac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggac      960

tggctgaacg gcaaagagta caagtgcaag gtgtccaaca agggcctgcc ctccagcatc     1020

gaaaagacca tctccaaggc caagggccag ccccgcgagc cccaggtgta caccctgccc     1080

cctagccagg aagagatgac caagaaccag gtgtccctga cctgtctggt caagggcttc     1140

tacccctccg acattgccgt ggaatgggag tccaacggcc agcccgagaa caactacaag     1200

accacccccc ctgtgctgga cagcgacggc tccttcttcc tgtactctcg gctgaccgtg     1260

gacaagtccc ggtggcagga aggcaacgtc ttctcctgct ccgtgatgca cgaggccctg     1320

cacaaccact acacccagaa gtccctgtcc ctgagcctgg gcaag                     1365


<210>  110
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH1 VH Y9F D19N

<400>  110

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Phe Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  111
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH1 VH Y9F D19N nucl.

<400>  111
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc aaggacagct ccaagaacac tgtgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctatg atgacttcgg ggactacccg acctactacg gaatgaaccc ttggggacag      360

ggcaccactg tgactgtctc gagc                                             384


<210>  112
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH1 Heavy Chain Y9F D19N

<400>  112

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Phe Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Leu Gly Lys 
    450                 455 


<210>  113
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH1 Heavy Chain Y9F D19N nucl.

<400>  113
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc aaggacagct ccaagaacac tgtgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctatg atgacttcgg ggactacccg acctactacg gaatgaaccc ttggggacag      360

ggcaccactg tgactgtctc gagcgcttct acaaagggcc cctccgtgtt ccctctggcc      420

ccttgctccc ggtccacctc cgagtctacc gccgctctgg gctgcctggt caaggactac      480

ttccccgagc ccgtgacagt gtcctggaac tctggcgccc tgacctccgg cgtgcacacc      540

ttccctgccg tgctgcagtc ctccggcctg tactccctgt cctccgtcgt gaccgtgccc      600

tcctccagcc tgggcaccaa gacctacacc tgtaacgtgg accacaagcc ctccaacacc      660

aaggtggaca agcgggtgga atctaagtac ggccctccct gccccccctg ccctgcccct      720

gaatttctgg gcggaccttc cgtgttcctg ttccccccaa agcccaagga caccctgatg      780

atctcccgga cccccgaagt gacctgcgtg gtggtggacg tgtcccagga agatcccgag      840

gtccagttca attggtacgt ggacggcgtg gaagtgcaca atgccaagac caagcccaga      900

gaggaacagt tcaactccac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggac      960

tggctgaacg gcaaagagta caagtgcaag gtgtccaaca agggcctgcc ctccagcatc     1020

gaaaagacca tctccaaggc caagggccag ccccgcgagc cccaggtgta caccctgccc     1080

cctagccagg aagagatgac caagaaccag gtgtccctga cctgtctggt caagggcttc     1140

tacccctccg acattgccgt ggaatgggag tccaacggcc agcccgagaa caactacaag     1200

accacccccc ctgtgctgga cagcgacggc tccttcttcc tgtactctcg gctgaccgtg     1260

gacaagtccc ggtggcagga aggcaacgtc ttctcctgct ccgtgatgca cgaggccctg     1320

cacaaccact acacccagaa gtccctgtcc ctgagcctgg gcaag                     1365


<210>  114
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH1 VH Y12F D19N

<400>  114

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Phe Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  115
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH1 VH Y12F D19N nucl.

<400>  115
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc aaggacagct ccaagaacac tgtgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctatg atgactacgg ggacttcccg acctactacg gaatgaaccc ttggggacag      360

ggcaccactg tgactgtctc gagc                                             384


<210>  116
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH1 Heavy Chain Y12F D19N

<400>  116

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Phe Pro Thr Tyr 
            100                 105                 110         


Tyr Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Leu Gly Lys 
    450                 455 


<210>  117
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH1 Heavy Chain Y12F D19N nucl.

<400>  117
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc aaggacagct ccaagaacac tgtgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctatg atgactacgg ggacttcccg acctactacg gaatgaaccc ttggggacag      360

ggcaccactg tgactgtctc gagcgcttct acaaagggcc cctccgtgtt ccctctggcc      420

ccttgctccc ggtccacctc cgagtctacc gccgctctgg gctgcctggt caaggactac      480

ttccccgagc ccgtgacagt gtcctggaac tctggcgccc tgacctccgg cgtgcacacc      540

ttccctgccg tgctgcagtc ctccggcctg tactccctgt cctccgtcgt gaccgtgccc      600

tcctccagcc tgggcaccaa gacctacacc tgtaacgtgg accacaagcc ctccaacacc      660

aaggtggaca agcgggtgga atctaagtac ggccctccct gccccccctg ccctgcccct      720

gaatttctgg gcggaccttc cgtgttcctg ttccccccaa agcccaagga caccctgatg      780

atctcccgga cccccgaagt gacctgcgtg gtggtggacg tgtcccagga agatcccgag      840

gtccagttca attggtacgt ggacggcgtg gaagtgcaca atgccaagac caagcccaga      900

gaggaacagt tcaactccac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggac      960

tggctgaacg gcaaagagta caagtgcaag gtgtccaaca agggcctgcc ctccagcatc     1020

gaaaagacca tctccaaggc caagggccag ccccgcgagc cccaggtgta caccctgccc     1080

cctagccagg aagagatgac caagaaccag gtgtccctga cctgtctggt caagggcttc     1140

tacccctccg acattgccgt ggaatgggag tccaacggcc agcccgagaa caactacaag     1200

accacccccc ctgtgctgga cagcgacggc tccttcttcc tgtactctcg gctgaccgtg     1260

gacaagtccc ggtggcagga aggcaacgtc ttctcctgct ccgtgatgca cgaggccctg     1320

cacaaccact acacccagaa gtccctgtcc ctgagcctgg gcaag                     1365


<210>  118
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH1 VH Y15F D19N

<400>  118

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Phe 
            100                 105                 110         


Tyr Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  119
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH1 VH Y15F D19N nucl.

<400>  119
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc aaggacagct ccaagaacac tgtgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctatg atgactacgg ggactacccg accttctacg gaatgaaccc ttggggacag      360

ggcaccactg tgactgtctc gagc                                             384


<210>  120
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH1 Heavy Chain Y15F D19N

<400>  120

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Phe 
            100                 105                 110         


Tyr Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Leu Gly Lys 
    450                 455 


<210>  121
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH1 Heavy Chain Y15F D19N nucl.

<400>  121
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc aaggacagct ccaagaacac tgtgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctatg atgactacgg ggactacccg accttctacg gaatgaaccc ttggggacag      360

ggcaccactg tgactgtctc gagcgcttct acaaagggcc cctccgtgtt ccctctggcc      420

ccttgctccc ggtccacctc cgagtctacc gccgctctgg gctgcctggt caaggactac      480

ttccccgagc ccgtgacagt gtcctggaac tctggcgccc tgacctccgg cgtgcacacc      540

ttccctgccg tgctgcagtc ctccggcctg tactccctgt cctccgtcgt gaccgtgccc      600

tcctccagcc tgggcaccaa gacctacacc tgtaacgtgg accacaagcc ctccaacacc      660

aaggtggaca agcgggtgga atctaagtac ggccctccct gccccccctg ccctgcccct      720

gaatttctgg gcggaccttc cgtgttcctg ttccccccaa agcccaagga caccctgatg      780

atctcccgga cccccgaagt gacctgcgtg gtggtggacg tgtcccagga agatcccgag      840

gtccagttca attggtacgt ggacggcgtg gaagtgcaca atgccaagac caagcccaga      900

gaggaacagt tcaactccac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggac      960

tggctgaacg gcaaagagta caagtgcaag gtgtccaaca agggcctgcc ctccagcatc     1020

gaaaagacca tctccaaggc caagggccag ccccgcgagc cccaggtgta caccctgccc     1080

cctagccagg aagagatgac caagaaccag gtgtccctga cctgtctggt caagggcttc     1140

tacccctccg acattgccgt ggaatgggag tccaacggcc agcccgagaa caactacaag     1200

accacccccc ctgtgctgga cagcgacggc tccttcttcc tgtactctcg gctgaccgtg     1260

gacaagtccc ggtggcagga aggcaacgtc ttctcctgct ccgtgatgca cgaggccctg     1320

cacaaccact acacccagaa gtccctgtcc ctgagcctgg gcaag                     1365


<210>  122
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH1 VH Y16F D19N

<400>  122

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Phe Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  123
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH1 VH Y16F D19N nucl.

<400>  123
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc aaggacagct ccaagaacac tgtgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctatg atgactacgg ggactacccg acctacttcg gaatgaaccc ttggggacag      360

ggcaccactg tgactgtctc gagc                                             384


<210>  124
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH1 Heavy Chain Y16F D19N

<400>  124

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr 
            100                 105                 110         


Phe Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Leu Gly Lys 
    450                 455 


<210>  125
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH1 Heavy Chain Y16F D19N nucl.

<400>  125
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc aaggacagct ccaagaacac tgtgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctatg atgactacgg ggactacccg acctacttcg gaatgaaccc ttggggacag      360

ggcaccactg tgactgtctc gagcgcttct acaaagggcc cctccgtgtt ccctctggcc      420

ccttgctccc ggtccacctc cgagtctacc gccgctctgg gctgcctggt caaggactac      480

ttccccgagc ccgtgacagt gtcctggaac tctggcgccc tgacctccgg cgtgcacacc      540

ttccctgccg tgctgcagtc ctccggcctg tactccctgt cctccgtcgt gaccgtgccc      600

tcctccagcc tgggcaccaa gacctacacc tgtaacgtgg accacaagcc ctccaacacc      660

aaggtggaca agcgggtgga atctaagtac ggccctccct gccccccctg ccctgcccct      720

gaatttctgg gcggaccttc cgtgttcctg ttccccccaa agcccaagga caccctgatg      780

atctcccgga cccccgaagt gacctgcgtg gtggtggacg tgtcccagga agatcccgag      840

gtccagttca attggtacgt ggacggcgtg gaagtgcaca atgccaagac caagcccaga      900

gaggaacagt tcaactccac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggac      960

tggctgaacg gcaaagagta caagtgcaag gtgtccaaca agggcctgcc ctccagcatc     1020

gaaaagacca tctccaaggc caagggccag ccccgcgagc cccaggtgta caccctgccc     1080

cctagccagg aagagatgac caagaaccag gtgtccctga cctgtctggt caagggcttc     1140

tacccctccg acattgccgt ggaatgggag tccaacggcc agcccgagaa caactacaag     1200

accacccccc ctgtgctgga cagcgacggc tccttcttcc tgtactctcg gctgaccgtg     1260

gacaagtccc ggtggcagga aggcaacgtc ttctcctgct ccgtgatgca cgaggccctg     1320

cacaaccact acacccagaa gtccctgtcc ctgagcctgg gcaag                     1365


<210>  126
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH1 VH T14N D19N nucl.

<400>  126

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Asn Tyr 
            100                 105                 110         


Tyr Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  127
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH1 VH T14N D19N nucl.

<400>  127
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc aaggacagct ccaagaacac tgtgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctatg atgactacgg ggactacccg aactactacg gaatgaaccc ttggggacag      360

ggcaccactg tgactgtctc gagc                                             384


<210>  128
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH1 Heavy Chain T14N D19N

<400>  128

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Asn Tyr 
            100                 105                 110         


Tyr Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Leu Gly Lys 
    450                 455 


<210>  129
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH1 Heavy Chain T14N D19N nucl.

<400>  129
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc aaggacagct ccaagaacac tgtgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctatg atgactacgg ggactacccg aactactacg gaatgaaccc ttggggacag      360

ggcaccactg tgactgtctc gagcgcttct acaaagggcc cctccgtgtt ccctctggcc      420

ccttgctccc ggtccacctc cgagtctacc gccgctctgg gctgcctggt caaggactac      480

ttccccgagc ccgtgacagt gtcctggaac tctggcgccc tgacctccgg cgtgcacacc      540

ttccctgccg tgctgcagtc ctccggcctg tactccctgt cctccgtcgt gaccgtgccc      600

tcctccagcc tgggcaccaa gacctacacc tgtaacgtgg accacaagcc ctccaacacc      660

aaggtggaca agcgggtgga atctaagtac ggccctccct gccccccctg ccctgcccct      720

gaatttctgg gcggaccttc cgtgttcctg ttccccccaa agcccaagga caccctgatg      780

atctcccgga cccccgaagt gacctgcgtg gtggtggacg tgtcccagga agatcccgag      840

gtccagttca attggtacgt ggacggcgtg gaagtgcaca atgccaagac caagcccaga      900

gaggaacagt tcaactccac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggac      960

tggctgaacg gcaaagagta caagtgcaag gtgtccaaca agggcctgcc ctccagcatc     1020

gaaaagacca tctccaaggc caagggccag ccccgcgagc cccaggtgta caccctgccc     1080

cctagccagg aagagatgac caagaaccag gtgtccctga cctgtctggt caagggcttc     1140

tacccctccg acattgccgt ggaatgggag tccaacggcc agcccgagaa caactacaag     1200

accacccccc ctgtgctgga cagcgacggc tccttcttcc tgtactctcg gctgaccgtg     1260

gacaagtccc ggtggcagga aggcaacgtc ttctcctgct ccgtgatgca cgaggccctg     1320

cacaaccact acacccagaa gtccctgtcc ctgagcctgg gcaag                     1365


<210>  130
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH1 VH T14V D19N

<400>  130

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Val Tyr 
            100                 105                 110         


Tyr Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  131
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH1 VH T14V D19N nucl.

<400>  131
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc aaggacagct ccaagaacac tgtgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctatg atgactacgg ggactacccg gtgtactacg gaatgaaccc ttggggacag      360

ggcaccactg tgactgtctc gagc                                             384


<210>  132
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH1 Heavy Chain T14V D19N

<400>  132

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Val Tyr 
            100                 105                 110         


Tyr Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Leu Gly Lys 
    450                 455 


<210>  133
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH1 Heavy Chain T14V D19N nucl.

<400>  133
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc aaggacagct ccaagaacac tgtgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctatg atgactacgg ggactacccg gtgtactacg gaatgaaccc ttggggacag      360

ggcaccactg tgactgtctc gagcgcttct acaaagggcc cctccgtgtt ccctctggcc      420

ccttgctccc ggtccacctc cgagtctacc gccgctctgg gctgcctggt caaggactac      480

ttccccgagc ccgtgacagt gtcctggaac tctggcgccc tgacctccgg cgtgcacacc      540

ttccctgccg tgctgcagtc ctccggcctg tactccctgt cctccgtcgt gaccgtgccc      600

tcctccagcc tgggcaccaa gacctacacc tgtaacgtgg accacaagcc ctccaacacc      660

aaggtggaca agcgggtgga atctaagtac ggccctccct gccccccctg ccctgcccct      720

gaatttctgg gcggaccttc cgtgttcctg ttccccccaa agcccaagga caccctgatg      780

atctcccgga cccccgaagt gacctgcgtg gtggtggacg tgtcccagga agatcccgag      840

gtccagttca attggtacgt ggacggcgtg gaagtgcaca atgccaagac caagcccaga      900

gaggaacagt tcaactccac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggac      960

tggctgaacg gcaaagagta caagtgcaag gtgtccaaca agggcctgcc ctccagcatc     1020

gaaaagacca tctccaaggc caagggccag ccccgcgagc cccaggtgta caccctgccc     1080

cctagccagg aagagatgac caagaaccag gtgtccctga cctgtctggt caagggcttc     1140

tacccctccg acattgccgt ggaatgggag tccaacggcc agcccgagaa caactacaag     1200

accacccccc ctgtgctgga cagcgacggc tccttcttcc tgtactctcg gctgaccgtg     1260

gacaagtccc ggtggcagga aggcaacgtc ttctcctgct ccgtgatgca cgaggccctg     1320

cacaaccact acacccagaa gtccctgtcc ctgagcctgg gcaag                     1365


<210>  134
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH1 VH T14S D19N

<400>  134

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Ser Tyr 
            100                 105                 110         


Tyr Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  135
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH1 VH T14S D19N nucl.

<400>  135
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc aaggacagct ccaagaacac tgtgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctatg atgactacgg ggactacccg tcctactacg gaatgaaccc ttggggacag      360

ggcaccactg tgactgtctc gagc                                             384


<210>  136
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 gH1 Heavy Chain T14S D19N

<400>  136

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Ser Tyr 
            100                 105                 110         


Tyr Gly Met Asn Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
    130                 135                 140                 


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
        195                 200                 205             


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Leu Gly Lys 
    450                 455 


<210>  137
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 gH1 Heavy Chain T14S D19N nucl.

<400>  137
gaagtgcagc tcgtcgaatc cggtggcgga ctggtgcagc ccggaggatc cctgaggctt       60

tcttgtgccg tgtccgggtt ctccctgagc tcctacggga tgtcgtgggt cagacaagca      120

ccaggaaagg gtctggagtg gatcggaatt atctcctcct cgggctcaac ctactacgcg      180

tcatgggcca agggccggtt caccattagc aaggacagct ccaagaacac tgtgtacctc      240

caaatgaact cgctgcgggc tgaggacacc gccgtgtact actgcgcccg cgatcacatc      300

taccgctatg atgactacgg ggactacccg tcctactacg gaatgaaccc ttggggacag      360

ggcaccactg tgactgtctc gagcgcttct acaaagggcc cctccgtgtt ccctctggcc      420

ccttgctccc ggtccacctc cgagtctacc gccgctctgg gctgcctggt caaggactac      480

ttccccgagc ccgtgacagt gtcctggaac tctggcgccc tgacctccgg cgtgcacacc      540

ttccctgccg tgctgcagtc ctccggcctg tactccctgt cctccgtcgt gaccgtgccc      600

tcctccagcc tgggcaccaa gacctacacc tgtaacgtgg accacaagcc ctccaacacc      660

aaggtggaca agcgggtgga atctaagtac ggccctccct gccccccctg ccctgcccct      720

gaatttctgg gcggaccttc cgtgttcctg ttccccccaa agcccaagga caccctgatg      780

atctcccgga cccccgaagt gacctgcgtg gtggtggacg tgtcccagga agatcccgag      840

gtccagttca attggtacgt ggacggcgtg gaagtgcaca atgccaagac caagcccaga      900

gaggaacagt tcaactccac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggac      960

tggctgaacg gcaaagagta caagtgcaag gtgtccaaca agggcctgcc ctccagcatc     1020

gaaaagacca tctccaaggc caagggccag ccccgcgagc cccaggtgta caccctgccc     1080

cctagccagg aagagatgac caagaaccag gtgtccctga cctgtctggt caagggcttc     1140

tacccctccg acattgccgt ggaatgggag tccaacggcc agcccgagaa caactacaag     1200

accacccccc ctgtgctgga cagcgacggc tccttcttcc tgtactctcg gctgaccgtg     1260

gacaagtccc ggtggcagga aggcaacgtc ttctcctgct ccgtgatgca cgaggccctg     1320

cacaaccact acacccagaa gtccctgtcc ctgagcctgg gcaag                     1365


<210>  138
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IGKV1D-13 JK4 acceptor framework

<400>  138

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  139
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IGKV1D-13 JK4 acceptor framework nucl.

<400>  139
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcattagc agtgctttag cctggtatca gcagaaacca      120

gggaaagctc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag tttaatagtt accctctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  140
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IGHV3-66 JH6 acceptor framework

<400>  140

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  141
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IGHV3-66 JH6 acceptor framework nucl.

<400>  141
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggcagatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag atactactac      300

tactacggta tggacgtctg ggggcaaggg accacggtca ccgtctcctc a               351


<210>  142
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human KLK5 (full length with signal sequence)

<400>  142

Met Ala Thr Ala Arg Pro Pro Trp Met Trp Val Leu Cys Ala Leu Ile 
1               5                   10                  15      


Thr Ala Leu Leu Leu Gly Val Thr Glu His Val Leu Ala Asn Asn Asp 
            20                  25                  30          


Val Ser Cys Asp His Pro Ser Asn Thr Val Pro Ser Gly Ser Asn Gln 
        35                  40                  45              


Asp Leu Gly Ala Gly Ala Gly Glu Asp Ala Arg Ser Asp Asp Ser Ser 
    50                  55                  60                  


Ser Arg Ile Ile Asn Gly Ser Asp Cys Asp Met His Thr Gln Pro Trp 
65                  70                  75                  80  


Gln Ala Ala Leu Leu Leu Arg Pro Asn Gln Leu Tyr Cys Gly Ala Val 
                85                  90                  95      


Leu Val His Pro Gln Trp Leu Leu Thr Ala Ala His Cys Arg Lys Lys 
            100                 105                 110         


Val Phe Arg Val Arg Leu Gly His Tyr Ser Leu Ser Pro Val Tyr Glu 
        115                 120                 125             


Ser Gly Gln Gln Met Phe Gln Gly Val Lys Ser Ile Pro His Pro Gly 
    130                 135                 140                 


Tyr Ser His Pro Gly His Ser Asn Asp Leu Met Leu Ile Lys Leu Asn 
145                 150                 155                 160 


Arg Arg Ile Arg Pro Thr Lys Asp Val Arg Pro Ile Asn Val Ser Ser 
                165                 170                 175     


His Cys Pro Ser Ala Gly Thr Lys Cys Leu Val Ser Gly Trp Gly Thr 
            180                 185                 190         


Thr Lys Ser Pro Gln Val His Phe Pro Lys Val Leu Gln Cys Leu Asn 
        195                 200                 205             


Ile Ser Val Leu Ser Gln Lys Arg Cys Glu Asp Ala Tyr Pro Arg Gln 
    210                 215                 220                 


Ile Asp Asp Thr Met Phe Cys Ala Gly Asp Lys Ala Gly Arg Asp Ser 
225                 230                 235                 240 


Cys Gln Gly Asp Ser Gly Gly Pro Val Val Cys Asn Gly Ser Leu Gln 
                245                 250                 255     


Gly Leu Val Ser Trp Gly Asp Tyr Pro Cys Ala Arg Pro Asn Arg Pro 
            260                 265                 270         


Gly Val Tyr Thr Asn Leu Cys Lys Phe Thr Lys Trp Ile Gln Glu Thr 
        275                 280                 285             


Ile Gln Ala Asn Ser 
    290             


<210>  143
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human KLK5 pro-form

<400>  143

Val Thr Glu His Val Leu Ala Asn Asn Asp Val Ser Cys Asp His Pro 
1               5                   10                  15      


Ser Asn Thr Val Pro Ser Gly Ser Asn Gln Asp Leu Gly Ala Gly Ala 
            20                  25                  30          


Gly Glu Asp Ala Arg Ser Asp Asp Ser Ser Ser Arg Ile Ile Asn Gly 
        35                  40                  45              


Ser Asp Cys Asp Met His Thr Gln Pro Trp Gln Ala Ala Leu Leu Leu 
    50                  55                  60                  


Arg Pro Asn Gln Leu Tyr Cys Gly Ala Val Leu Val His Pro Gln Trp 
65                  70                  75                  80  


Leu Leu Thr Ala Ala His Cys Arg Lys Lys Val Phe Arg Val Arg Leu 
                85                  90                  95      


Gly His Tyr Ser Leu Ser Pro Val Tyr Glu Ser Gly Gln Gln Met Phe 
            100                 105                 110         


Gln Gly Val Lys Ser Ile Pro His Pro Gly Tyr Ser His Pro Gly His 
        115                 120                 125             


Ser Asn Asp Leu Met Leu Ile Lys Leu Asn Arg Arg Ile Arg Pro Thr 
    130                 135                 140                 


Lys Asp Val Arg Pro Ile Asn Val Ser Ser His Cys Pro Ser Ala Gly 
145                 150                 155                 160 


Thr Lys Cys Leu Val Ser Gly Trp Gly Thr Thr Lys Ser Pro Gln Val 
                165                 170                 175     


His Phe Pro Lys Val Leu Gln Cys Leu Asn Ile Ser Val Leu Ser Gln 
            180                 185                 190         


Lys Arg Cys Glu Asp Ala Tyr Pro Arg Gln Ile Asp Asp Thr Met Phe 
        195                 200                 205             


Cys Ala Gly Asp Lys Ala Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly 
    210                 215                 220                 


Gly Pro Val Val Cys Asn Gly Ser Leu Gln Gly Leu Val Ser Trp Gly 
225                 230                 235                 240 


Asp Tyr Pro Cys Ala Arg Pro Asn Arg Pro Gly Val Tyr Thr Asn Leu 
                245                 250                 255     


Cys Lys Phe Thr Lys Trp Ile Gln Glu Thr Ile Gln Ala Asn Ser 
            260                 265                 270     


<210>  144
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Active human KLK5

<400>  144

Ile Ile Asn Gly Ser Asp Cys Asp Met His Thr Gln Pro Trp Gln Ala 
1               5                   10                  15      


Ala Leu Leu Leu Arg Pro Asn Gln Leu Tyr Cys Gly Ala Val Leu Val 
            20                  25                  30          


His Pro Gln Trp Leu Leu Thr Ala Ala His Cys Arg Lys Lys Val Phe 
        35                  40                  45              


Arg Val Arg Leu Gly His Tyr Ser Leu Ser Pro Val Tyr Glu Ser Gly 
    50                  55                  60                  


Gln Gln Met Phe Gln Gly Val Lys Ser Ile Pro His Pro Gly Tyr Ser 
65                  70                  75                  80  


His Pro Gly His Ser Asn Asp Leu Met Leu Ile Lys Leu Asn Arg Arg 
                85                  90                  95      


Ile Arg Pro Thr Lys Asp Val Arg Pro Ile Asn Val Ser Ser His Cys 
            100                 105                 110         


Pro Ser Ala Gly Thr Lys Cys Leu Val Ser Gly Trp Gly Thr Thr Lys 
        115                 120                 125             


Ser Pro Gln Val His Phe Pro Lys Val Leu Gln Cys Leu Asn Ile Ser 
    130                 135                 140                 


Val Leu Ser Gln Lys Arg Cys Glu Asp Ala Tyr Pro Arg Gln Ile Asp 
145                 150                 155                 160 


Asp Thr Met Phe Cys Ala Gly Asp Lys Ala Gly Arg Asp Ser Cys Gln 
                165                 170                 175     


Gly Asp Ser Gly Gly Pro Val Val Cys Asn Gly Ser Leu Gln Gly Leu 
            180                 185                 190         


Val Ser Trp Gly Asp Tyr Pro Cys Ala Arg Pro Asn Arg Pro Gly Val 
        195                 200                 205             


Tyr Thr Asn Leu Cys Lys Phe Thr Lys Trp Ile Gln Glu Thr Ile Gln 
    210                 215                 220                 


Ala Asn Ser 
225         


<210>  145
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human LEKTI D5 Rabbit Fc

<400>  145

Glu Ile Val Lys Leu Cys Ser Gln Tyr Gln Asn Gln Ala Lys Asn Gly 
1               5                   10                  15      


Ile Leu Phe Cys Thr Arg Glu Asn Asp Pro Ile Arg Gly Pro Asp Gly 
            20                  25                  30          


Lys Met His Gly Asn Leu Cys Ser Met Cys Gln Ala Tyr Phe Gln Ala 
        35                  40                  45              


Glu Asn Glu Glu Lys Lys Lys Ala Glu Ala Arg Ala Arg Asn Leu Glu 
    50                  55                  60                  


Lys Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro 
65                  70                  75                  80  


Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys 
                85                  90                  95      


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            100                 105                 110         


Asp Val Ser Gln Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn 
        115                 120                 125             


Asn Glu Gln Val Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe 
    130                 135                 140                 


Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Ala His Gln Asp 
145                 150                 155                 160 


Trp Leu Arg Gly Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu 
                165                 170                 175     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu 
            180                 185                 190         


Glu Pro Lys Val Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser 
        195                 200                 205             


Arg Ser Val Ser Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp 
    210                 215                 220                 


Ile Ser Val Glu Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys 
225                 230                 235                 240 


Thr Thr Pro Ala Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser 
                245                 250                 255     


Lys Leu Ser Val Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr 
            260                 265                 270         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        275                 280                 285             


Ile Ser Arg Ser Pro Gly Lys 
    290                 295 


<210>  146
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human KLK7 pro-form

<400>  146

Glu Glu Ala Gln Gly Asp Lys Ile Ile Asp Gly Ala Pro Cys Ala Arg 
1               5                   10                  15      


Gly Ser His Pro Trp Gln Val Ala Leu Leu Ser Gly Asn Gln Leu His 
            20                  25                  30          


Cys Gly Gly Val Leu Val Asn Glu Arg Trp Val Leu Thr Ala Ala His 
        35                  40                  45              


Cys Lys Met Asn Glu Tyr Thr Val His Leu Gly Ser Asp Thr Leu Gly 
    50                  55                  60                  


Asp Arg Arg Ala Gln Arg Ile Lys Ala Ser Lys Ser Phe Arg His Pro 
65                  70                  75                  80  


Gly Tyr Ser Thr Gln Thr His Val Asn Asp Leu Met Leu Val Lys Leu 
                85                  90                  95      


Asn Ser Gln Ala Arg Leu Ser Ser Met Val Lys Lys Val Arg Leu Pro 
            100                 105                 110         


Ser Arg Cys Glu Pro Pro Gly Thr Thr Cys Thr Val Ser Gly Trp Gly 
        115                 120                 125             


Thr Thr Thr Ser Pro Asp Val Thr Phe Pro Ser Asp Leu Met Cys Val 
    130                 135                 140                 


Asp Val Lys Leu Ile Ser Pro Gln Asp Cys Thr Lys Val Tyr Lys Asp 
145                 150                 155                 160 


Leu Leu Glu Asn Ser Met Leu Cys Ala Gly Ile Pro Asp Ser Lys Lys 
                165                 170                 175     


Asn Ala Cys Asn Gly Asp Ser Gly Gly Pro Leu Val Cys Arg Gly Thr 
            180                 185                 190         


Leu Gln Gly Leu Val Ser Trp Gly Thr Phe Pro Cys Gly Gln Pro Asn 
        195                 200                 205             


Asp Pro Gly Val Tyr Thr Gln Val Cys Lys Phe Thr Lys Trp Ile Asn 
    210                 215                 220                 


Asp Thr Met Lys Lys His Arg 
225                 230     


<210>  147
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Active himan KLK7

<400>  147

Ile Ile Asp Gly Ala Pro Cys Ala Arg Gly Ser His Pro Trp Gln Val 
1               5                   10                  15      


Ala Leu Leu Ser Gly Asn Gln Leu His Cys Gly Gly Val Leu Val Asn 
            20                  25                  30          


Glu Arg Trp Val Leu Thr Ala Ala His Cys Lys Met Asn Glu Tyr Thr 
        35                  40                  45              


Val His Leu Gly Ser Asp Thr Leu Gly Asp Arg Arg Ala Gln Arg Ile 
    50                  55                  60                  


Lys Ala Ser Lys Ser Phe Arg His Pro Gly Tyr Ser Thr Gln Thr His 
65                  70                  75                  80  


Val Asn Asp Leu Met Leu Val Lys Leu Asn Ser Gln Ala Arg Leu Ser 
                85                  90                  95      


Ser Met Val Lys Lys Val Arg Leu Pro Ser Arg Cys Glu Pro Pro Gly 
            100                 105                 110         


Thr Thr Cys Thr Val Ser Gly Trp Gly Thr Thr Thr Ser Pro Asp Val 
        115                 120                 125             


Thr Phe Pro Ser Asp Leu Met Cys Val Asp Val Lys Leu Ile Ser Pro 
    130                 135                 140                 


Gln Asp Cys Thr Lys Val Tyr Lys Asp Leu Leu Glu Asn Ser Met Leu 
145                 150                 155                 160 


Cys Ala Gly Ile Pro Asp Ser Lys Lys Asn Ala Cys Asn Gly Asp Ser 
                165                 170                 175     


Gly Gly Pro Leu Val Cys Arg Gly Thr Leu Gln Gly Leu Val Ser Trp 
            180                 185                 190         


Gly Thr Phe Pro Cys Gly Gln Pro Asn Asp Pro Gly Val Tyr Thr Gln 
        195                 200                 205             


Val Cys Lys Phe Thr Lys Trp Ile Asn Asp Thr Met Lys Lys His Arg 
    210                 215                 220                 


<210>  148
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyno KLK7 pro-form

<400>  148

Gly Gln Glu Ala Gln Gly Asp Lys Ile Ile Asp Gly Ala Pro Cys Thr 
1               5                   10                  15      


Arg Gly Ser His Pro Trp Gln Val Ala Leu Leu Ser Gly Asn Gln Leu 
            20                  25                  30          


His Cys Gly Gly Val Leu Val Asn Glu Arg Trp Val Leu Thr Ala Ala 
        35                  40                  45              


His Cys Lys Met Asn Asp Tyr Ile Val His Leu Gly Ser Asp Thr Leu 
    50                  55                  60                  


Gly Asp Arg Lys Ala Gln Arg Ile Lys Ala Ser Arg Ser Phe Arg His 
65                  70                  75                  80  


Pro Gly Tyr Ser Thr Gln Thr His Val Asn Asp Leu Met Leu Val Lys 
                85                  90                  95      


Leu Asn Ser Pro Ala Arg Leu Ser Ser Thr Val Lys Lys Val Arg Leu 
            100                 105                 110         


Pro Ser Arg Cys Glu Pro Pro Gly Thr Thr Cys Thr Val Ser Gly Trp 
        115                 120                 125             


Gly Thr Thr Thr Ser Pro Asp Val Thr Phe Pro Ser Asp Leu Met Cys 
    130                 135                 140                 


Val Asp Val Lys Leu Ile Ser Ser Gln Asp Cys Thr Lys Val Tyr Lys 
145                 150                 155                 160 


Asp Met Leu Gly Asn Ser Met Leu Cys Ala Gly Ile Pro Asn Ser Lys 
                165                 170                 175     


Lys Asn Ala Cys Asn Gly Asp Ser Gly Gly Pro Leu Val Cys Arg Gly 
            180                 185                 190         


Thr Leu Gln Gly Leu Val Ser Trp Gly Thr Phe Pro Cys Gly Gln Pro 
        195                 200                 205             


Asn Asp Pro Gly Val Tyr Thr Gln Val Cys Lys Phe Thr Lys Trp Ile 
    210                 215                 220                 


Asn Asp Thr Ile Lys Lys His Arg 
225                 230         


<210>  149
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Active Cyno KLK7

<400>  149

Ile Ile Asp Gly Ala Pro Cys Thr Arg Gly Ser His Pro Trp Gln Val 
1               5                   10                  15      


Ala Leu Leu Ser Gly Asn Gln Leu His Cys Gly Gly Val Leu Val Asn 
            20                  25                  30          


Glu Arg Trp Val Leu Thr Ala Ala His Cys Lys Met Asn Asp Tyr Ile 
        35                  40                  45              


Val His Leu Gly Ser Asp Thr Leu Gly Asp Arg Lys Ala Gln Arg Ile 
    50                  55                  60                  


Lys Ala Ser Arg Ser Phe Arg His Pro Gly Tyr Ser Thr Gln Thr His 
65                  70                  75                  80  


Val Asn Asp Leu Met Leu Val Lys Leu Asn Ser Pro Ala Arg Leu Ser 
                85                  90                  95      


Ser Thr Val Lys Lys Val Arg Leu Pro Ser Arg Cys Glu Pro Pro Gly 
            100                 105                 110         


Thr Thr Cys Thr Val Ser Gly Trp Gly Thr Thr Thr Ser Pro Asp Val 
        115                 120                 125             


Thr Phe Pro Ser Asp Leu Met Cys Val Asp Val Lys Leu Ile Ser Ser 
    130                 135                 140                 


Gln Asp Cys Thr Lys Val Tyr Lys Asp Met Leu Gly Asn Ser Met Leu 
145                 150                 155                 160 


Cys Ala Gly Ile Pro Asn Ser Lys Lys Asn Ala Cys Asn Gly Asp Ser 
                165                 170                 175     


Gly Gly Pro Leu Val Cys Arg Gly Thr Leu Gln Gly Leu Val Ser Trp 
            180                 185                 190         


Gly Thr Phe Pro Cys Gly Gln Pro Asn Asp Pro Gly Val Tyr Thr Gln 
        195                 200                 205             


Val Cys Lys Phe Thr Lys Trp Ile Asn Asp Thr Ile Lys Lys His Arg 
    210                 215                 220                 


<210>  150
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Active mouse KLK5

<400>  150

Ile Val Asn Gly Ser Asp Cys Gln Lys Asp Ala Gln Pro Trp Gln Gly 
1               5                   10                  15      


Ala Leu Leu Leu Gly Pro Asn Lys Leu Tyr Cys Gly Ala Val Leu Ile 
            20                  25                  30          


Ser Pro Gln Trp Leu Leu Thr Ala Ala His Cys Arg Lys Pro Val Phe 
        35                  40                  45              


Arg Ile Arg Leu Gly His His Ser Met Ser Pro Val Tyr Glu Ser Gly 
    50                  55                  60                  


Gln Gln Met Phe Gln Gly Ile Lys Ser Ile Pro His Pro Gly Tyr Ser 
65                  70                  75                  80  


His Pro Gly His Ser Asn Asp Leu Met Leu Ile Lys Met Asn Arg Lys 
                85                  90                  95      


Ile Arg Asp Ser His Ser Val Lys Pro Val Glu Ile Ala Cys Asp Cys 
            100                 105                 110         


Ala Thr Glu Gly Thr Arg Cys Met Val Ser Gly Trp Gly Thr Thr Ser 
        115                 120                 125             


Ser Ser His Asn Asn Phe Pro Lys Val Leu Gln Cys Leu Asn Ile Thr 
    130                 135                 140                 


Val Leu Ser Glu Glu Arg Cys Lys Asn Ser Tyr Pro Gly Gln Ile Asp 
145                 150                 155                 160 


Lys Thr Met Phe Cys Ala Gly Asp Glu Glu Gly Arg Asp Ser Cys Gln 
                165                 170                 175     


Gly Asp Ser Gly Gly Pro Val Val Cys Asn Gly Lys Leu Gln Gly Leu 
            180                 185                 190         


Val Ser Trp Gly Asp Phe Pro Cys Ala Gln Arg Asn Arg Pro Gly Val 
        195                 200                 205             


Tyr Thr Asn Leu Cys Glu Phe Val Lys Trp Ile Lys Asp Thr Met Asn 
    210                 215                 220                 


Ser Asn 
225     


<210>  151
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  active Cyno KLK5

<400>  151

Ile Ile Asn Gly Ser Asp Cys Asp Glu His Thr Gln Pro Trp Gln Ala 
1               5                   10                  15      


Ala Leu Leu Leu Gly Pro Asn Gln Leu Tyr Cys Gly Gly Val Leu Val 
            20                  25                  30          


His Pro Gln Trp Leu Leu Thr Ala Ala His Cys Arg Lys Lys Val Phe 
        35                  40                  45              


Arg Val Arg Leu Gly His Tyr Ser Leu Ser Pro Val Tyr Glu Ser Gly 
    50                  55                  60                  


Gln Gln Met Phe Gln Gly Ile Lys Ser Ile Pro His Pro Gly Tyr Ser 
65                  70                  75                  80  


His Pro Gly His Ser Asn Asp Leu Met Leu Ile Lys Leu Asn Arg Arg 
                85                  90                  95      


Ile His Ser Thr Lys Asp Val Arg Pro Ile Asn Val Ser Ser His Cys 
            100                 105                 110         


Pro Ser Ala Gly Thr Lys Cys Leu Val Ser Gly Trp Gly Thr Thr Arg 
        115                 120                 125             


Ser Pro Gln Val His Phe Pro Lys Val Leu Gln Cys Leu Asn Ile Ser 
    130                 135                 140                 


Val Leu Ser Gln Lys Arg Cys Glu Asp Ala Tyr Pro Arg Gln Ile Asp 
145                 150                 155                 160 


Asp Thr Met Phe Cys Ala Gly Asp Glu Ala Gly Arg Asp Ser Cys Gln 
                165                 170                 175     


Gly Asp Ser Gly Gly Pro Val Val Cys Asn Gly Ser Leu Gln Gly Leu 
            180                 185                 190         


Val Ser Trp Gly Asp Tyr Pro Cys Ala Lys Pro Asn Arg Pro Gly Val 
        195                 200                 205             


Tyr Thr Asn Leu Cys Lys Phe Thr Lys Trp Ile Gln Glu Thr Ile Gln 
    210                 215                 220                 


Ala Asn Ser 
225         


<210>  152
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human LEKTI D8 Rabbit Fc

<400>  152

Glu Ala Ala Lys Glu Ile Cys Ser Glu Phe Arg Asp Gln Val Arg Asn 
1               5                   10                  15      


Gly Thr Leu Ile Cys Thr Arg Glu His Asn Pro Val Arg Gly Pro Asp 
            20                  25                  30          


Gly Lys Met His Gly Asn Lys Cys Ala Met Cys Ala Ser Val Phe Lys 
        35                  40                  45              


Leu Glu Glu Glu Glu Lys Lys Asn Asp Lys Glu Glu Lys Gly Lys Val 
    50                  55                  60                  


Glu Ala Glu Lys Val Leu Glu Lys Thr Val Ala Pro Ser Thr Cys Ser 
65                  70                  75                  80  


Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                85                  90                  95      


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            100                 105                 110         


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Asp Asp Pro Glu Val 
        115                 120                 125             


Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val Arg Thr Ala Arg Pro 
    130                 135                 140                 


Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile Arg Val Val Ser Thr 
145                 150                 155                 160 


Leu Pro Ile Ala His Gln Asp Trp Leu Arg Gly Lys Glu Phe Lys Cys 
                165                 170                 175     


Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            180                 185                 190         


Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val Tyr Thr Met Gly Pro 
        195                 200                 205             


Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser Leu Thr Cys Met Ile 
    210                 215                 220                 


Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Lys Asn Gly 
225                 230                 235                 240 


Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala Val Leu Asp Ser Asp 
                245                 250                 255     


Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Pro Thr Ser Glu Trp 
            260                 265                 270         


Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met His Glu Ala Leu His 
        275                 280                 285             


Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser Pro Gly Lys 
    290                 295                 300         


<210>  153
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rabbit 10273 mIgG Light Chain

<400>  153

Ala Val Val Leu Thr Gln Thr Pro Ser Pro Met Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Gln Ser Val Tyr Asn Asn 
            20                  25                  30          


Asn Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Asp 
                85                  90                  95      


Asp Val Asp Thr Tyr Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg Thr Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Cys 
                165                 170                 175     


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 


<210>  154
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rabbit 10273 mIgG  Heavy Chain

<400>  154

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Gly 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Ala 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp His 
                85                  90                  95      


Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Pro Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala Lys Thr 
        115                 120                 125             


Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr 
    130                 135                 140                 


Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser 
            180                 185                 190         


Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn 
        195                 200                 205             


Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro 
    210                 215                 220                 


Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr 
                245                 250                 255     


Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp 
            260                 265                 270         


Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr 
        275                 280                 285             


Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser 
    290                 295                 300                 


Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr 
            340                 345                 350         


Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr 
        355                 360                 365             


Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln 
    370                 375                 380                 


Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met 
385                 390                 395                 400 


Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys 
                405                 410                 415     


Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu 
            420                 425                 430         


Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  155
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabbit 10273 mIgG Light Chain Nucl.

<400>  155
gcagtcgtgc tgactcagac accatcaccc atgtctgcag ctgtgggagg cacagtcacc       60

atcagttgcc agtccagtca gagtgtttat aataataacg acttagcctg gtatcagcag      120

aaaccagggc agcctcctaa gctcctgatc tacagggcat ccactctggc atctggggtc      180

ccgtcgcggt tcagcggcag tggatctggg acacagttca ctctcaccat cagcggcgtg      240

cagtgtgacg atgctgccac ttactactgt ctaggcggtt atgatgatga tgttgatacg      300

tatactttcg gcggagggac cgaggtggtg gtcaaacgta cggatgctgc accaactgta      360

tccatcttcc caccatccag tgagcagtta acatctggag gtgcctcagt cgtgtgcttc      420

ttgaacaact tctaccccaa agacatcaat gtcaagtgga agattgatgg cagtgaacga      480

caaaatggcg tcctgaacag ttggactgat caggacagca aagactgcac ctacagcatg      540

agcagcaccc tcacgttgac caaggacgag tatgaacgac ataacagcta tacctgtgag      600

gccactcaca agacatcaac ttcacccatt gtcaagagct tcaacaggaa tgagtgt         657


<210>  156
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabbit 10273 mIgG Heavy Chain Nucl.

<400>  156
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcagtagc tatggaatga gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggaattatt agtagtagtg gtagcacata ctacgcgagc      180

tgggcgaaag gccgattcac catctccaag acctcgacca cggtggatct gaaaatcgcc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagatcacat ttataggtac      300

gatgactatg gtgattaccc tacctactac ggcatggacc cctggggccc aggcaccctg      360

gtcaccgtct cgagtgccaa aacgacaccc ccatctgtct atccactggc ccctggatct      420

gctgcccaaa ctaactccat ggtgaccctg ggatgcctgg tcaagggcta tttccctgag      480

ccagtgacag tgacctggaa ctctggatcc ctgtccagcg gtgtgcacac cttcccagct      540

gtcctgcagt ctgacctcta cactctgagc agctcagtga ctgtcccctc cagcacctgg      600

cccagcgaga ccgtcacctg caacgttgcc cacccggcca gcagcaccaa ggtggacaag      660

aaaattgtgc ccagggattg tggttgtaag ccttgcatat gtacagtccc agaagtatca      720

tctgtcttca tcttcccccc aaagcccaag gatgtgctca ccattactct gactcctaag      780

gtcacgtgtg ttgtggtaga catcagcaag gatgatcccg aggtccagtt cagctggttt      840

gtagatgatg tggaggtgca cacagctcag acgcaacccc gggaggagca gttcaacagc      900

actttccgct cagtcagtga acttcccatc atgcaccagg actggctcaa tggcaaggag      960

ttcaaatgca gggtcaacag tgcagctttc cctgccccca tcgagaaaac catctccaaa     1020

accaaaggca gaccgaaggc tccacaggtg tacaccattc cacctcccaa ggagcagatg     1080

gccaaggata aagtcagtct gacctgcatg ataacagact tcttccctga agacattact     1140

gtggagtggc agtggaatgg gcagccagcg gagaactaca agaacactca gcccatcatg     1200

gacacagatg gctcttactt cgtctacagc aagctcaatg tgcagaagag caactgggag     1260

gcaggaaata ctttcacctg ctctgtgtta catgagggcc tgcacaacca ccatactgag     1320

aagagcctct cccactctcc tggtaaa                                         1347


<210>  157
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rabbit 10236 mIgG Light Chain

<400>  157

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Asn Ser Asn 
                85                  90                  95      


Ile Ile Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
            100                 105                 110         


Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu 
        115                 120                 125             


Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn 
145                 150                 155                 160 


Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Cys Thr Tyr 
                165                 170                 175     


Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His 
            180                 185                 190         


Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile 
        195                 200                 205             


Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215         


<210>  158
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rabbit 10236 mIgG Heavy Chain

<400>  158

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Pro Leu Ser Asn Tyr Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Asp Ile Tyr Pro Ser Asp Ile Ile Asp Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Gln Thr Ser Thr Thr Val Glu Leu Lys Ile Thr 
65                  70                  75                  80  


Gly Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Asn 
                85                  90                  95      


Asn Asp Tyr Gly Leu Asp Ile Trp Gly Pro Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly 
        115                 120                 125             


Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu 
145                 150                 155                 160 


Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr 
                165                 170                 175     


Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu 
            180                 185                 190         


Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp 
        195                 200                 205             


Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr 
    210                 215                 220                 


Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
225                 230                 235                 240 


Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp 
                245                 250                 255     


Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp 
            260                 265                 270         


Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn 
        275                 280                 285             


Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp 
    290                 295                 300                 


Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro 
305                 310                 315                 320 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala 
                325                 330                 335     


Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp 
            340                 345                 350         


Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile 
        355                 360                 365             


Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn 
    370                 375                 380                 


Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys 
385                 390                 395                 400 


Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys 
                405                 410                 415     


Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu 
            420                 425                 430         


Ser His Ser Pro Gly Lys 
        435             


<210>  159
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabbit 10236 mIgG Light Chain Nucl.

<400>  159
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtca gagcattagc agttggttag cctggtatca gcagaaacca      120

ggtcagcctc ccaagctcct gatctatctg gcatccactc tggcatctgg ggtctcatcg      180

cggttcaaag gcagtggatc tgggacacag ttcactctca ccatcagcgg cgtggagtgt      240

gccgatgctg ccacttacta ctgtcaacag ggttatacta atagtaatat tattaatact      300

ttcggcggag ggaccgaggt ggtggtcaaa cgtacggatg ctgcaccaac tgtatccatc      360

ttcccaccat ccagtgagca gttaacatct ggaggtgcct cagtcgtgtg cttcttgaac      420

aacttctacc ccaaagacat caatgtcaag tggaagattg atggcagtga acgacaaaat      480

ggcgtcctga acagttggac tgatcaggac agcaaagact gcacctacag catgagcagc      540

accctcacgt tgaccaagga cgagtatgaa cgacataaca gctatacctg tgaggccact      600

cacaagacat caacttcacc cattgtcaag agcttcaaca ggaatgagtg t               651


<210>  160
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabbit 10236 mIgG Heavy Chain Nucl.

<400>  160
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctgggttccc cctcagtaat tatgcaatga gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggagacatt tatcctagtg atatcataga ctacgcgagc      180

tgggcgaaag gccgattcac catctcccaa acctcgacca cggtggagct gaaaatcacg      240

ggtccgacaa ccgaggacac ggccacctat ttctgtgcca gagacaacaa tgactatggt      300

ctggacatct ggggcccagg caccctggtc accgtctcga gtgccaaaac gacaccccca      360

tctgtctatc cactggcccc tggatctgct gcccaaacta actccatggt gaccctggga      420

tgcctggtca agggctattt ccctgagcca gtgacagtga cctggaactc tggatccctg      480

tccagcggtg tgcacacctt cccagctgtc ctgcagtctg acctctacac tctgagcagc      540

tcagtgactg tcccctccag cacctggccc agcgagaccg tcacctgcaa cgttgcccac      600

ccggccagca gcaccaaggt ggacaagaaa attgtgccca gggattgtgg ttgtaagcct      660

tgcatatgta cagtcccaga agtatcatct gtcttcatct tccccccaaa gcccaaggat      720

gtgctcacca ttactctgac tcctaaggtc acgtgtgttg tggtagacat cagcaaggat      780

gatcccgagg tccagttcag ctggtttgta gatgatgtgg aggtgcacac agctcagacg      840

caaccccggg aggagcagtt caacagcact ttccgctcag tcagtgaact tcccatcatg      900

caccaggact ggctcaatgg caaggagttc aaatgcaggg tcaacagtgc agctttccct      960

gcccccatcg agaaaaccat ctccaaaacc aaaggcagac cgaaggctcc acaggtgtac     1020

accattccac ctcccaagga gcagatggcc aaggataaag tcagtctgac ctgcatgata     1080

acagacttct tccctgaaga cattactgtg gagtggcagt ggaatgggca gccagcggag     1140

aactacaaga acactcagcc catcatggac acagatggct cttacttcgt ctacagcaag     1200

ctcaatgtgc agaagagcaa ctgggaggca ggaaatactt tcacctgctc tgtgttacat     1260

gagggcctgc acaaccacca tactgagaag agcctctccc actctcctgg taaatgatcc     1320

cagtgtcctt ggagccctct ggtcctacag gactctgaca cctacctcca cccctccctg     1380

tataaa                                                                1386


<210>  161
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10236 Light chain Fab

<400>  161

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Asn Ser Asn 
                85                  90                  95      


Ile Ile Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
            100                 105                 110         


Pro Val Ala Pro Thr Val Leu Ile Phe Pro Pro Ala Ala Asp Gln Val 
        115                 120                 125             


Ala Thr Gly Thr Val Thr Ile Val Cys Val Ala Asn Lys Tyr Phe Pro 
    130                 135                 140                 


Asp Val Thr Val Thr Trp Glu Val Asp Gly Thr Thr Gln Thr Thr Gly 
145                 150                 155                 160 


Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala Asp Cys Thr Tyr Asn 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln Tyr Asn Ser His Lys 
            180                 185                 190         


Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr Ser Val Val Gln Ser 
        195                 200                 205             


Phe Asn Arg Gly Asp Cys 
    210                 


<210>  162
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10236 Light Chain Fab Nucl.

<400>  162
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtca gagcattagc agttggttag cctggtatca gcagaaacca      120

ggtcagcctc ccaagctcct gatctatctg gcatccactc tggcatctgg ggtctcatcg      180

cggttcaaag gcagtggatc tgggacacag ttcactctca ccatcagcgg cgtggagtgt      240

gccgatgctg ccacttacta ctgtcaacag ggttatacta atagtaatat tattaatact      300

ttcggcggag ggaccgaggt ggtggtcaaa cgtacgccag ttgcacctac tgtcctcatc      360

ttcccaccag ctgctgatca ggtggcaact ggaacagtca ccatcgtgtg tgtggcgaat      420

aaatactttc ccgatgtcac cgtcacctgg gaggtggatg gcaccaccca aacaactggc      480

atcgagaaca gtaaaacacc gcagaattct gcagattgta cctacaacct cagcagcact      540

ctgacactga ccagcacaca gtacaacagc cacaaagagt acacctgcaa ggtgacccag      600

ggcacgacct cagtcgtcca gagcttcaat aggggtgact gt                         642


<210>  163
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10236 heavy chain Fab

<400>  163

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Pro Leu Ser Asn Tyr Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Asp Ile Tyr Pro Ser Asp Ile Ile Asp Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Gln Thr Ser Thr Thr Val Glu Leu Lys Ile Thr 
65                  70                  75                  80  


Gly Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Asn 
                85                  90                  95      


Asn Asp Tyr Gly Leu Asp Ile Trp Gly Pro Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys 
        115                 120                 125             


Cys Gly Asp Thr Pro Ser Ser Thr Val Thr Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Gly Tyr Leu Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Thr Leu 
145                 150                 155                 160 


Thr Asn Gly Val Arg Thr Phe Pro Ser Val Arg Gln Ser Ser Gly Leu 
                165                 170                 175     


Tyr Ser Leu Ser Ser Val Val Ser Val Thr Ser Ser Ser Gln Pro Val 
            180                 185                 190         


Thr Cys Asn Val Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Thr 
        195                 200                 205             


Val Ala Pro Ser Thr Cys Ser Lys Pro 
    210                 215         


<210>  164
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10236 heavy chain Fab Nucl.

<400>  164
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctgggttccc cctcagtaat tatgcaatga gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggagacatt tatcctagtg atatcataga ctacgcgagc      180

tgggcgaaag gccgattcac catctcccaa acctcgacca cggtggagct gaaaatcacg      240

ggtccgacaa ccgaggacac ggccacctat ttctgtgcca gagacaacaa tgactatggt      300

ctggacatct ggggcccagg caccctggtc accgtctcga gtgggcaacc taaggctcca      360

tcagtcttcc cactggcccc ctgctgcggg gacacaccca gctccacggt gaccctgggc      420

tgcctggtca aaggctacct cccggagcca gtgaccgtga cctggaactc gggcaccctc      480

accaatgggg tacgcacctt cccgtccgtc cggcagtcct caggcctcta ctcgctgagc      540

agcgtggtga gcgtgacctc aagcagccag cccgtcacct gcaacgtggc ccacccagcc      600

accaacacca aagtggacaa gaccgttgcg ccctcgacat gcagcaagcc c               651


<210>  165
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273 Light chain Fab

<400>  165

Ala Val Val Leu Thr Gln Thr Pro Ser Pro Met Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Gln Ser Val Tyr Asn Asn 
            20                  25                  30          


Asn Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Asp 
                85                  90                  95      


Asp Val Asp Thr Tyr Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg Thr Pro Val Ala Pro Thr Val Leu Ile Phe Pro Pro Ala Ala Asp 
        115                 120                 125             


Gln Val Ala Thr Gly Thr Val Thr Ile Val Cys Val Ala Asn Lys Tyr 
    130                 135                 140                 


Phe Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly Thr Thr Gln Thr 
145                 150                 155                 160 


Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala Asp Cys Thr 
                165                 170                 175     


Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln Tyr Asn Ser 
            180                 185                 190         


His Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr Ser Val Val 
        195                 200                 205             


Gln Ser Phe Asn Arg Gly Asp Cys 
    210                 215     


<210>  166
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273  Light Chain Fab Nucl.

<400>  166
gcagtcgtgc tgactcagac accatcaccc atgtctgcag ctgtgggagg cacagtcacc       60

atcagttgcc agtccagtca gagtgtttat aataataacg acttagcctg gtatcagcag      120

aaaccagggc agcctcctaa gctcctgatc tacagggcat ccactctggc atctggggtc      180

ccgtcgcggt tcagcggcag tggatctggg acacagttca ctctcaccat cagcggcgtg      240

cagtgtgacg atgctgccac ttactactgt ctaggcggtt atgatgatga tgttgatacg      300

tatactttcg gcggagggac cgaggtggtg gtcaaacgta cgccagttgc acctactgtc      360

ctcatcttcc caccagctgc tgatcaggtg gcaactggaa cagtcaccat cgtgtgtgtg      420

gcgaataaat actttcccga tgtcaccgtc acctgggagg tggatggcac cacccaaaca      480

actggcatcg agaacagtaa aacaccgcag aattctgcag attgtaccta caacctcagc      540

agcactctga cactgaccag cacacagtac aacagccaca aagagtacac ctgcaaggtg      600

acccagggca cgacctcagt cgtccagagc ttcaataggg gtgactgt                   648


<210>  167
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10273  heavy chain Fab

<400>  167

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Gly 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Ala 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp His 
                85                  90                  95      


Ile Tyr Arg Tyr Asp Asp Tyr Gly Asp Tyr Pro Thr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Pro Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gln Pro 
        115                 120                 125             


Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly Asp Thr Pro 
    130                 135                 140                 


Ser Ser Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Leu Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Thr Trp Asn Ser Gly Thr Leu Thr Asn Gly Val Arg 
                165                 170                 175     


Thr Phe Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Ser Val Thr Ser Ser Ser Gln Pro Val Thr Cys Asn Val Ala 
        195                 200                 205             


His Pro Ala Thr Asn Thr Lys Val Asp Lys Thr Val Ala Pro Ser Thr 
    210                 215                 220                 


Cys Ser Lys Pro 
225             


<210>  168
<211>  684
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10273 heavy chain Fab Nucl.

<400>  168
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcagtagc tatggaatga gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggaattatt agtagtagtg gtagcacata ctacgcgagc      180

tgggcgaaag gccgattcac catctccaag acctcgacca cggtggatct gaaaatcgcc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagatcacat ttataggtac      300

gatgactatg gtgattaccc tacctactac ggcatggacc cctggggccc aggcaccctg      360

gtcaccgtct cgagtgggca acctaaggct ccatcagtct tcccactggc cccctgctgc      420

ggggacacac ccagctccac ggtgaccctg ggctgcctgg tcaaaggcta cctcccggag      480

ccagtgaccg tgacctggaa ctcgggcacc ctcaccaatg gggtacgcac cttcccgtcc      540

gtccggcagt cctcaggcct ctactcgctg agcagcgtgg tgagcgtgac ctcaagcagc      600

cagcccgtca cctgcaacgt ggcccaccca gccaccaaca ccaaagtgga caagaccgtt      660

gcgccctcga catgcagcaa gccc                                             684


<210>  169
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human LEKTI D5 Fab H chain

<400>  169

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Trp Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gly Gly Gly Gly Ser Gly 
65                  70                  75                  80  


Gly Gly Gly Ser Arg Glu Ile Val Lys Leu Cys Ser Gln Tyr Gln Asn 
                85                  90                  95      


Gln Ala Lys Asn Gly Ile Leu Phe Cys Thr Arg Glu Asn Asp Pro Ile 
            100                 105                 110         


Arg Gly Pro Asp Gly Lys Met His Gly Asn Leu Cys Ser Met Cys Gln 
        115                 120                 125             


Ala Tyr Phe Gln Ala Glu Asn Glu Glu Lys Lys Lys Ala Glu Ala Arg 
    130                 135                 140                 


Ala Arg Ser Gly Gly Gly Gly Gly Gly Gly Gly Ser Lys Asn Thr Val 
145                 150                 155                 160 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                165                 170                 175     


Cys Ala Arg Thr Val Pro Gly Tyr Ser Thr Ala Pro Tyr Phe Asp Leu 
            180                 185                 190         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        195                 200                 205             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    210                 215                 220                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
225                 230                 235                 240 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                245                 250                 255     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            260                 265                 270         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        275                 280                 285             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    290                 295                 300                 


Ser Cys His His His His His His His His His His 
305                 310                 315     


<210>  170
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human LEKTI D5 Fab L chain

<400>  170

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Pro Ser Val Trp Ser Asn 
            20                  25                  30          


Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Ala Ser Lys Leu Thr Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gly Gly Tyr Ser Ser Ile 
                85                  90                  95      


Ser Asp Thr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  171
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rabbit/human chimeric light chain (hCK S171C) 10236

<400>  171

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Asn Ser Asn 
                85                  90                  95      


Ile Ile Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Cys Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  172
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rabbit/human chimeric heavy chain 10236

<400>  172

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Pro Leu Ser Asn Tyr Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Asp Ile Tyr Pro Ser Asp Ile Ile Asp Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Gln Thr Ser Thr Thr Val Glu Leu Lys Ile Thr 
65                  70                  75                  80  


Gly Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Asn 
                85                  90                  95      


Asn Asp Tyr Gly Leu Asp Ile Trp Gly Pro Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys 
        115                 120                 125             


Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         


Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             


Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440     


<210>  173
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LEKTI-D5-Fc TEV

<400>  173

Glu Ile Val Lys Leu Cys Ser Gln Tyr Gln Asn Gln Ala Lys Asn Gly 
1               5                   10                  15      


Ile Leu Phe Cys Thr Arg Glu Asn Asp Pro Ile Arg Gly Pro Asp Gly 
            20                  25                  30          


Lys Met His Gly Asn Leu Cys Ser Met Cys Gln Ala Tyr Phe Gln Ala 
        35                  40                  45              


Glu Asn Glu Glu Lys Lys Lys Ala Glu Ala Arg Ala Arg Asn Leu Glu 
    50                  55                  60                  


Glu Asn Leu Tyr Phe Gln Gly Val Asp Lys Lys Val Glu Pro Lys Ser 
65                  70                  75                  80  


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                85                  90                  95      


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            100                 105                 110         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        115                 120                 125             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    130                 135                 140                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
145                 150                 155                 160 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                165                 170                 175     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            180                 185                 190         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        195                 200                 205             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    210                 215                 220                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
225                 230                 235                 240 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                245                 250                 255     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            260                 265                 270         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        275                 280                 285             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    290                 295                 300                 


Ser Pro Gly Lys 
305             


<210>  174
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LEKTI-D8-Fc TEV

<400>  174

Glu Ala Ala Lys Glu Ile Cys Ser Glu Phe Arg Asp Gln Val Arg Asn 
1               5                   10                  15      


Gly Thr Leu Ile Cys Thr Arg Glu His Asn Pro Val Arg Gly Pro Asp 
            20                  25                  30          


Gly Lys Met His Gly Asn Lys Cys Ala Met Cys Ala Ser Val Phe Lys 
        35                  40                  45              


Leu Glu Glu Glu Glu Lys Lys Asn Asp Lys Glu Glu Lys Gly Lys Val 
    50                  55                  60                  


Glu Ala Glu Lys Val Leu Glu Glu Asn Leu Tyr Phe Gln Gly Val Asp 
65                  70                  75                  80  


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                85                  90                  95      


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            100                 105                 110         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        115                 120                 125             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    130                 135                 140                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
145                 150                 155                 160 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                165                 170                 175     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            180                 185                 190         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        195                 200                 205             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    210                 215                 220                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
225                 230                 235                 240 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                245                 250                 255     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            260                 265                 270         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        275                 280                 285             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    290                 295                 300                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
305                 310                 315 


<210>  175
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10236 CDR-L1

<400>  175

Gln Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  176
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10236 CDR-L2

<400>  176

Leu Ala Ser Thr Leu Ala Ser 
1               5           


<210>  177
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10236 CDR-L3

<400>  177

Gln Gln Gly Tyr Thr Asn Ser Asn Ile Ile Asn Thr 
1               5                   10          


<210>  178
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10236 CDR-H1

<400>  178

Gly Phe Pro Leu Ser Asn Tyr Ala Met Ser 
1               5                   10  


<210>  179
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10236 CDR-H2

<400>  179

Asp Ile Tyr Pro Ser Asp Ile Ile Asp Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  180
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10236 CDR-H3

<400>  180

Asp Asn Asn Asp Tyr Gly Leu Asp Ile 
1               5                   


<210>  181
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10236 Rabbit VL

<400>  181

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Asn Ser Asn 
                85                  90                  95      


Ile Ile Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110 


<210>  182
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10236 Rabbit VL nucl.

<400>  182
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtca gagcattagc agttggttag cctggtatca gcagaaacca      120

ggtcagcctc ccaagctcct gatctatctg gcatccactc tggcatctgg ggtctcatcg      180

cggttcaaag gcagtggatc tgggacacag ttcactctca ccatcagcgg cgtggagtgt      240

gccgatgctg ccacttacta ctgtcaacag ggttatacta atagtaatat tattaatact      300

ttcggcggag ggaccgaggt ggtggtcaaa cgtacg                                336


<210>  183
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10236 Rabbit VH

<400>  183

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Pro Leu Ser Asn Tyr Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Asp Ile Tyr Pro Ser Asp Ile Ile Asp Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Gln Thr Ser Thr Thr Val Glu Leu Lys Ile Thr 
65                  70                  75                  80  


Gly Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Asn 
                85                  90                  95      


Asn Asp Tyr Gly Leu Asp Ile Trp Gly Pro Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  184
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10236 Rabbit VH nucl.

<400>  184
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcaccgtct ctgggttccc cctcagtaat tatgcaatga gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggagacatt tatcctagtg atatcataga ctacgcgagc      180

tgggcgaaag gccgattcac catctcccaa acctcgacca cggtggagct gaaaatcacg      240

ggtccgacaa ccgaggacac ggccacctat ttctgtgcca gagacaacaa tgactatggt      300

ctggacatct ggggcccagg caccctggtc accgtctcga gt                         342


<210>  185
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse KLK7 pro-form

<400>  185

Gln Gly Glu Arg Ile Ile Asp Gly Tyr Lys Cys Lys Glu Gly Ser His 
1               5                   10                  15      


Pro Trp Gln Val Ala Leu Leu Lys Gly Asn Gln Leu His Cys Gly Gly 
            20                  25                  30          


Val Leu Val Asp Lys Tyr Trp Val Leu Thr Ala Ala His Cys Lys Met 
        35                  40                  45              


Gly Gln Tyr Gln Val Gln Leu Gly Ser Asp Lys Ile Gly Asp Gln Ser 
    50                  55                  60                  


Ala Gln Lys Ile Lys Ala Thr Lys Ser Phe Arg His Pro Gly Tyr Ser 
65                  70                  75                  80  


Thr Lys Thr His Val Asn Asp Ile Met Leu Val Arg Leu Asp Glu Pro 
                85                  90                  95      


Val Lys Met Ser Ser Lys Val Glu Ala Val Gln Leu Pro Glu His Cys 
            100                 105                 110         


Glu Pro Pro Gly Thr Ser Cys Thr Val Ser Gly Trp Gly Thr Thr Thr 
        115                 120                 125             


Ser Pro Asp Val Thr Phe Pro Ser Asp Leu Met Cys Ser Asp Val Lys 
    130                 135                 140                 


Leu Ile Ser Ser Arg Glu Cys Lys Lys Val Tyr Lys Asp Leu Leu Gly 
145                 150                 155                 160 


Lys Thr Met Leu Cys Ala Gly Ile Pro Asp Ser Lys Thr Asn Thr Cys 
                165                 170                 175     


Asn Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Asp Thr Leu Gln Gly 
            180                 185                 190         


Leu Val Ser Trp Gly Thr Tyr Pro Cys Gly Gln Pro Asn Asp Pro Gly 
        195                 200                 205             


Val Tyr Thr Gln Val Cys Lys Tyr Lys Arg Trp Val Met Glu Thr Met 
    210                 215                 220                 


Lys Thr His Arg 
225             


<210>  186
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Active Mouse KLK7

<400>  186

Ile Ile Asp Gly Tyr Lys Cys Lys Glu Gly Ser His Pro Trp Gln Val 
1               5                   10                  15      


Ala Leu Leu Lys Gly Asn Gln Leu His Cys Gly Gly Val Leu Val Asp 
            20                  25                  30          


Lys Tyr Trp Val Leu Thr Ala Ala His Cys Lys Met Gly Gln Tyr Gln 
        35                  40                  45              


Val Gln Leu Gly Ser Asp Lys Ile Gly Asp Gln Ser Ala Gln Lys Ile 
    50                  55                  60                  


Lys Ala Thr Lys Ser Phe Arg His Pro Gly Tyr Ser Thr Lys Thr His 
65                  70                  75                  80  


Val Asn Asp Ile Met Leu Val Arg Leu Asp Glu Pro Val Lys Met Ser 
                85                  90                  95      


Ser Lys Val Glu Ala Val Gln Leu Pro Glu His Cys Glu Pro Pro Gly 
            100                 105                 110         


Thr Ser Cys Thr Val Ser Gly Trp Gly Thr Thr Thr Ser Pro Asp Val 
        115                 120                 125             


Thr Phe Pro Ser Asp Leu Met Cys Ser Asp Val Lys Leu Ile Ser Ser 
    130                 135                 140                 


Arg Glu Cys Lys Lys Val Tyr Lys Asp Leu Leu Gly Lys Thr Met Leu 
145                 150                 155                 160 


Cys Ala Gly Ile Pro Asp Ser Lys Thr Asn Thr Cys Asn Gly Asp Ser 
                165                 170                 175     


Gly Gly Pro Leu Val Cys Asn Asp Thr Leu Gln Gly Leu Val Ser Trp 
            180                 185                 190         


Gly Thr Tyr Pro Cys Gly Gln Pro Asn Asp Pro Gly Val Tyr Thr Gln 
        195                 200                 205             


Val Cys Lys Tyr Lys Arg Trp Val Met Glu Thr Met Lys Thr His Arg 
    210                 215                 220                 


