                         SEQUENCE LISTING

<110>  Pathologie Hamburg-West
       Prof. Dr.  Christoph Wagener
       Universittsklinikum Hamburg-Eppendorf
       Kinderkrebs-Zentrum Hamburg gemeinntzige GmbH
 
<120>  Marker set for the diagnosis and treatment of cancer

<130>  H/NIE-13-WO

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Lys Asp Asp Phe Ala Glu Glu Glu Glu Val Gln Ser Phe Gly Tyr 
1               5                   10                  15      


Lys Arg Phe Gly Ile Gln Glu Gly Thr Gln Cys Thr Lys Cys Lys Asn 
            20                  25                  30          


Asn Trp Ala Leu Lys Phe Ser Ile Ile Leu Leu Tyr Ile Leu Cys Ala 
        35                  40                  45              


Leu Leu Thr Ile Thr Val Ala Ile Leu Gly Tyr Lys Val Val Glu Lys 
    50                  55                  60                  


Met Asp Asn Val Thr Gly Gly Met Glu Thr Ser Arg Gln Thr Tyr Asp 
65                  70                  75                  80  


Asp Lys Leu Thr Ala Val Glu Ser Asp Leu Lys Lys Leu Gly Asp Gln 
                85                  90                  95      


Thr Gly Lys Lys Ala Ile Ser Thr Asn Ser Glu Leu Ser Thr Phe Arg 
            100                 105                 110         


Ser Asp Ile Leu Asp Leu Arg Gln Gln Leu Arg Glu Ile Thr Glu Lys 
        115                 120                 125             


Thr Ser Lys Asn Lys Asp Thr Leu Glu Lys Leu Gln Ala Ser Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Arg Gln Ser Gln Leu Lys Glu Thr Leu Glu Asn Asn 
145                 150                 155                 160 


Ser Phe Leu Ile Thr Thr Val Asn Lys Thr Leu Gln Ala Tyr Asn Gly 
                165                 170                 175     


Tyr Val Thr Asn Leu Gln Gln Asp Thr Ser Val Leu Gln Gly Asn Leu 
            180                 185                 190         


Gln Asn Gln Met Tyr Ser His Asn Val Val Ile Met Asn Leu Asn Asn 
        195                 200                 205             


Leu Asn Leu Thr Gln Val Gln Gln Arg Asn Leu Ile Thr Asn Leu Gln 
    210                 215                 220                 


Arg Ser Val Asp Asp Thr Ser Gln Ala Ile Gln Arg Ile Lys Asn Asp 
225                 230                 235                 240 


Phe Gln Asn Leu Gln Gln Val Phe Leu Gln Ala Lys Lys Asp Thr Asp 
                245                 250                 255     


Trp Leu Lys Glu Lys Val Gln Ser Leu Gln Thr Leu Ala Ala Asn Asn 
            260                 265                 270         


Ser Ala Leu Ala Lys Ala Asn Asn Asp Thr Leu Glu Asp Met Asn Ser 
        275                 280                 285             


Gln Leu Asn Ser Phe Thr Gly Gln Met Glu Asn Ile Thr Thr Ile Ser 
    290                 295                 300                 


Gln Ala Asn Glu Gln Asn Leu Lys Asp Leu Gln Asp Leu His Lys Asp 
305                 310                 315                 320 


Ala Glu Asn Arg Thr Ala Ile Lys Phe Asn Gln Leu Glu Glu Arg Phe 
                325                 330                 335     


Gln Leu Phe Glu Thr Asp Ile Val Asn Ile Ile Ser Asn Ile Ser Tyr 
            340                 345                 350         


Thr Ala His His Leu Arg Thr Leu Thr Ser Asn Leu Asn Glu Val Arg 
        355                 360                 365             


Thr Thr Cys Thr Asp Thr Leu Thr Lys His Thr Asp Asp Leu Thr Ser 
    370                 375                 380                 


Leu Asn Asn Thr Leu Ala Asn Ile Arg Leu Asp Ser Val Ser Leu Arg 
385                 390                 395                 400 


Met Gln Gln Asp Leu Met Arg Ser Arg Leu Asp Thr Glu Val Ala Asn 
                405                 410                 415     


Leu Ser Val Ile Met Glu Glu Met Lys Leu Val Asp Ser Lys His Gly 
            420                 425                 430         


Gln Leu Ile Lys Asn Phe Thr Ile Leu Gln Gly Pro Pro Gly Pro Arg 
        435                 440                 445             


Gly Pro Arg Gly Asp Arg Gly Ser Gln Gly Pro Pro Gly Pro Thr Gly 
    450                 455                 460                 


Asn Lys Gly Gln Lys Gly Glu Lys Gly Glu Pro Gly Pro Pro Gly Pro 
465                 470                 475                 480 


Ala Gly Glu Arg Gly Pro Ile Gly Pro Ala Gly Pro Pro Gly Glu Arg 
                485                 490                 495     


Gly Gly Lys Gly Ser Lys Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly 
            500                 505                 510         


Ser Pro Gly Lys Pro Gly Pro Gln Gly Ser Ser Gly Asp Pro Gly Pro 
        515                 520                 525             


Pro Gly Pro Pro Gly Lys Glu Gly Leu Pro Gly Pro Gln Gly Pro Pro 
    530                 535                 540                 


Gly Phe Gln Gly Leu Gln Gly Thr Val Gly Glu Pro Gly Val Pro Gly 
545                 550                 555                 560 


Pro Arg Gly Leu Pro Gly Leu Pro Gly Val Pro Gly Met Pro Gly Pro 
                565                 570                 575     


Lys Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Ala Val Val Pro Leu 
            580                 585                 590         


Ala Leu Gln Asn Glu Pro Thr Pro Ala Pro Glu Asp Asn Gly Cys Pro 
        595                 600                 605             


Pro His Trp Lys Asn Phe Thr Asp Lys Cys Tyr Tyr Phe Ser Val Glu 
    610                 615                 620                 


Lys Glu Ile Phe Glu Asp Ala Lys Leu Phe Cys Glu Asp Lys Ser Ser 
625                 630                 635                 640 


His Leu Val Phe Ile Asn Thr Arg Glu Glu Gln Gln Trp Ile Lys Lys 
                645                 650                 655     


Gln Met Val Gly Arg Glu Ser His Trp Ile Gly Leu Thr Asp Ser Glu 
            660                 665                 670         


Arg Glu Asn Glu Trp Lys Trp Leu Asp Gly Thr Ser Pro Asp Tyr Lys 
        675                 680                 685             


Asn Trp Lys Ala Gly Gln Pro Asp Asn Trp Gly His Gly His Gly Pro 
    690                 695                 700                 


Gly Glu Asp Cys Ala Gly Leu Ile Tyr Ala Gly Gln Trp Asn Asp Phe 
705                 710                 715                 720 


Gln Cys Glu Asp Val Asn Asn Phe Ile Cys Glu Lys Asp Arg Glu Thr 
                725                 730                 735     


Val Leu Ser Ser Ala Leu 
            740         


<210>  2
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Thr Thr Arg Tyr Ser Lys Trp Gly Gly Ser Ser Glu Glu Val 
1               5                   10                  15      


Pro Gly Gly Pro Trp Gly Arg Trp Val His Trp Ser Arg Arg Pro Leu 
            20                  25                  30          


Phe Leu Ala Leu Ala Val Leu Val Thr Thr Val Leu Trp Ala Val Ile 
        35                  40                  45              


Leu Ser Ile Leu Leu Ser Lys Ala Ser Thr Glu Arg Ala Ala Leu Leu 
    50                  55                  60                  


Asp Gly His Asp Leu Leu Arg Thr Asn Ala Ser Lys Gln Thr Ala Ala 
65                  70                  75                  80  


Leu Gly Ala Leu Lys Glu Glu Val Gly Asp Cys His Ser Cys Cys Ser 
                85                  90                  95      


Gly Thr Gln Ala Gln Leu Gln Thr Thr Arg Ala Glu Leu Gly Glu Ala 
            100                 105                 110         


Gln Ala Lys Leu Met Glu Gln Glu Ser Ala Leu Arg Glu Leu Arg Glu 
        115                 120                 125             


Arg Val Thr Gln Gly Leu Ala Glu Ala Gly Arg Gly Arg Glu Asp Val 
    130                 135                 140                 


Arg Thr Glu Leu Phe Arg Ala Leu Glu Ala Val Arg Leu Gln Asn Asn 
145                 150                 155                 160 


Ser Cys Glu Pro Cys Pro Thr Ser Trp Leu Ser Phe Glu Gly Ser Cys 
                165                 170                 175     


Tyr Phe Phe Ser Val Pro Lys Thr Thr Trp Ala Ala Ala Gln Asp His 
            180                 185                 190         


Cys Ala Asp Ala Ser Ala His Leu Val Ile Val Gly Gly Leu Asp Glu 
        195                 200                 205             


Gln Gly Phe Leu Thr Arg Asn Thr Arg Gly Arg Gly Tyr Trp Leu Gly 
    210                 215                 220                 


Leu Arg Ala Val Arg His Leu Gly Lys Val Gln Gly Tyr Gln Trp Val 
225                 230                 235                 240 


Asp Gly Val Ser Leu Ser Phe Ser His Trp Asn Gln Gly Glu Pro Asn 
                245                 250                 255     


Asp Ala Trp Gly Arg Glu Asn Cys Val Met Met Leu His Thr Gly Leu 
            260                 265                 270         


Trp Asn Asp Ala Pro Cys Asp Ser Glu Lys Asp Gly Trp Ile Cys Glu 
        275                 280                 285             


Lys Arg His Asn Cys 
    290             


<210>  3
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Thr Val Glu Lys Glu Ala Pro Asp Ala His Phe Thr Val Asp Lys 
1               5                   10                  15      


Gln Asn Ile Ser Leu Trp Pro Arg Glu Pro Pro Pro Lys Ser Gly Pro 
            20                  25                  30          


Ser Leu Val Pro Gly Lys Thr Pro Thr Val Arg Ala Ala Leu Ile Cys 
        35                  40                  45              


Leu Thr Leu Val Leu Val Ala Ser Val Leu Leu Gln Ala Val Leu Tyr 
    50                  55                  60                  


Pro Arg Phe Met Gly Thr Ile Ser Asp Val Lys Thr Asn Val Gln Leu 
65                  70                  75                  80  


Leu Lys Gly Arg Val Asp Asn Ile Ser Thr Leu Asp Ser Glu Ile Lys 
                85                  90                  95      


Lys Asn Ser Asp Gly Met Glu Ala Ala Gly Val Gln Ile Gln Met Val 
            100                 105                 110         


Asn Glu Ser Leu Gly Tyr Val Arg Ser Gln Phe Leu Lys Leu Lys Thr 
        115                 120                 125             


Ser Val Glu Lys Ala Asn Ala Gln Ile Gln Ile Leu Thr Arg Ser Trp 
    130                 135                 140                 


Glu Glu Val Ser Thr Leu Asn Ala Gln Ile Pro Glu Leu Lys Ser Asp 
145                 150                 155                 160 


Leu Glu Lys Ala Ser Ala Leu Asn Thr Lys Ile Arg Ala Leu Gln Gly 
                165                 170                 175     


Ser Leu Glu Asn Met Ser Lys Leu Leu Lys Arg Gln Asn Asp Ile Leu 
            180                 185                 190         


Gln Val Val Ser Gln Gly Trp Lys Tyr Phe Lys Gly Asn Phe Tyr Tyr 
        195                 200                 205             


Phe Ser Leu Ile Pro Lys Thr Trp Tyr Ser Ala Glu Gln Phe Cys Val 
    210                 215                 220                 


Ser Arg Asn Ser His Leu Thr Ser Val Thr Ser Glu Ser Glu Gln Glu 
225                 230                 235                 240 


Phe Leu Tyr Lys Thr Ala Gly Gly Leu Ile Tyr Trp Ile Gly Leu Thr 
                245                 250                 255     


Lys Ala Gly Met Glu Gly Asp Trp Ser Trp Val Asp Asp Thr Pro Phe 
            260                 265                 270         


Asn Lys Val Gln Ser Val Arg Phe Trp Ile Pro Gly Glu Pro Asn Asn 
        275                 280                 285             


Ala Gly Asn Asn Glu His Cys Gly Asn Ile Lys Ala Pro Ser Leu Gln 
    290                 295                 300                 


Ala Trp Asn Asp Ala Pro Cys Asp Lys Thr Phe Leu Phe Ile Cys Lys 
305                 310                 315                 320 


Arg Pro Tyr Val Pro Ser Glu Pro 
                325             


<210>  4
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Thr Arg Thr Tyr Glu Asn Phe Gln Tyr Leu Glu Asn Lys Val Lys 
1               5                   10                  15      


Val Gln Gly Phe Lys Asn Gly Pro Leu Pro Leu Gln Ser Leu Leu Gln 
            20                  25                  30          


Arg Leu Cys Ser Gly Pro Cys His Leu Leu Leu Ser Leu Gly Leu Gly 
        35                  40                  45              


Leu Leu Leu Leu Val Ile Ile Cys Val Val Gly Phe Gln Asn Ser Lys 
    50                  55                  60                  


Phe Gln Arg Asp Leu Val Thr Leu Arg Thr Asp Phe Ser Asn Phe Thr 
65                  70                  75                  80  


Ser Asn Thr Val Ala Glu Ile Gln Ala Leu Thr Ser Gln Gly Ser Ser 
                85                  90                  95      


Leu Glu Glu Thr Ile Ala Ser Leu Lys Ala Glu Val Glu Gly Phe Lys 
            100                 105                 110         


Gln Glu Arg Gln Ala Gly Val Ser Glu Leu Gln Glu His Thr Thr Gln 
        115                 120                 125             


Lys Ala His Leu Gly His Cys Pro His Cys Pro Ser Val Cys Val Pro 
    130                 135                 140                 


Val His Ser Glu Met Leu Leu Arg Val Gln Gln Leu Val Gln Asp Leu 
145                 150                 155                 160 


Lys Lys Leu Thr Cys Gln Val Ala Thr Leu Asn Asn Asn Ala Ser Thr 
                165                 170                 175     


Glu Gly Thr Cys Cys Pro Val Asn Trp Val Glu His Gln Asp Ser Cys 
            180                 185                 190         


Tyr Trp Phe Ser His Ser Gly Met Ser Trp Ala Glu Ala Glu Lys Tyr 
        195                 200                 205             


Cys Gln Leu Lys Asn Ala His Leu Val Val Ile Asn Ser Arg Glu Glu 
    210                 215                 220                 


Gln Asn Phe Val Gln Lys Tyr Leu Gly Ser Ala Tyr Thr Trp Met Gly 
225                 230                 235                 240 


Leu Ser Asp Pro Glu Gly Ala Trp Lys Trp Val Asp Gly Thr Asp Tyr 
                245                 250                 255     


Ala Thr Gly Phe Gln Asn Trp Lys Pro Gly Gln Pro Asp Asp Trp Gln 
            260                 265                 270         


Gly His Gly Leu Gly Gly Gly Glu Asp Cys Ala His Phe His Pro Asp 
        275                 280                 285             


Gly Arg Trp Asn Asp Asp Val Cys Gln Arg Pro Tyr His Trp Val Cys 
    290                 295                 300                 


Glu Ala Gly Leu Gly Gln Thr Ser Gln Glu Ser His 
305                 310                 315     


<210>  5
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Asn Gly Cys Pro Pro His Trp Lys Asn Phe Thr Asp Lys Cys Tyr 
1               5                   10                  15      


Tyr Phe Ser Val Glu Lys Glu Ile Phe Glu Asp Ala Lys Leu Phe Cys 
            20                  25                  30          


Glu Asp Lys Ser Ser His Leu Val Phe Ile Asn Thr Arg Glu Glu Gln 
        35                  40                  45              


Gln Trp Ile Lys Lys Gln Met Val Gly Arg Glu Ser His Trp Ile Gly 
    50                  55                  60                  


Leu Thr Asp Ser Glu Arg Glu Asn Glu Trp Lys Trp Leu Asp Gly Thr 
65                  70                  75                  80  


Ser Pro Asp Tyr Lys Asn Trp Lys Ala Gly Gln Pro Asp Asn Trp Gly 
                85                  90                  95      


His Gly His Gly Pro Gly Glu Asp Cys Ala Gly Leu Ile Tyr Ala Gly 
            100                 105                 110         


Gln Trp Asn Asp Phe Gln Cys Glu Asp Val Asn Asn Phe Ile Cys Glu 
        115                 120                 125             


Lys Asp Arg Glu Thr Val Leu Ser Ser Ala Leu 
    130                 135                 


<210>  6
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  6

Cys Glu Pro Cys Pro Thr Ser Trp Leu Ser Phe Glu Gly Ser Cys Tyr 
1               5                   10                  15      


Phe Phe Ser Val Pro Lys Thr Thr Trp Ala Ala Ala Gln Asp His Cys 
            20                  25                  30          


Ala Asp Ala Ser Ala His Leu Val Ile Val Gly Gly Leu Asp Glu Gln 
        35                  40                  45              


Gly Phe Leu Thr Arg Asn Thr Arg Gly Arg Gly Tyr Trp Leu Gly Leu 
    50                  55                  60                  


Arg Ala Val Arg His Leu Gly Lys Val Gln Gly Tyr Gln Trp Val Asp 
65                  70                  75                  80  


Gly Val Ser Leu Ser Phe Ser His Trp Asn Gln Gly Glu Pro Asn Asp 
                85                  90                  95      


Ala Trp Gly Arg Glu Asn Cys Val Met Met Leu His Thr Gly Leu Trp 
            100                 105                 110         


Asn Asp Ala Pro Cys Asp Ser Glu Lys Asp Gly Trp Ile Cys Glu Lys 
        115                 120                 125             


Arg His Asn Cys 
    130         


<210>  7
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  7

Leu Gln Val Val Ser Gln Gly Trp Lys Tyr Phe Lys Gly Asn Phe Tyr 
1               5                   10                  15      


Tyr Phe Ser Leu Ile Pro Lys Thr Trp Tyr Ser Ala Glu Gln Phe Cys 
            20                  25                  30          


Val Ser Arg Asn Ser His Leu Thr Ser Val Thr Ser Glu Ser Glu Gln 
        35                  40                  45              


Glu Phe Leu Tyr Lys Thr Ala Gly Gly Leu Ile Tyr Trp Ile Gly Leu 
    50                  55                  60                  


Thr Lys Ala Gly Met Glu Gly Asp Trp Ser Trp Val Asp Asp Thr Pro 
65                  70                  75                  80  


Phe Asn Lys Val Gln Ser Val Arg Phe Trp Ile Pro Gly Glu Pro Asn 
                85                  90                  95      


Asn Ala Gly Asn Asn Glu His Cys Gly Asn Ile Lys Ala Pro Ser Leu 
            100                 105                 110         


Gln Ala Trp Asn Asp Ala Pro Cys Asp Lys Thr Phe Leu Phe Ile Cys 
        115                 120                 125             


Lys Arg Pro Tyr Val Pro Ser Glu Pro 
    130                 135         


<210>  8
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  8

Glu Gly Thr Cys Cys Pro Val Asn Trp Val Glu His Gln Asp Ser Cys 
1               5                   10                  15      


Tyr Trp Phe Ser His Ser Gly Met Ser Trp Ala Glu Ala Glu Lys Tyr 
            20                  25                  30          


Cys Gln Leu Lys Asn Ala His Leu Val Val Ile Asn Ser Arg Glu Glu 
        35                  40                  45              


Gln Asn Phe Val Gln Lys Tyr Leu Gly Ser Ala Tyr Thr Trp Met Gly 
    50                  55                  60                  


Leu Ser Asp Pro Glu Gly Ala Trp Lys Trp Val Asp Gly Thr Asp Tyr 
65                  70                  75                  80  


Ala Thr Gly Phe Gln Asn Trp Lys Pro Gly Gln Pro Asp Asp Trp Gln 
                85                  90                  95      


Gly His Gly Leu Gly Gly Gly Glu Asp Cys Ala His Phe His Pro Asp 
            100                 105                 110         


Gly Arg Trp Asn Asp Asp Val Cys Gln Arg Pro Tyr His Trp Val Cys 
        115                 120                 125             


Glu Ala Gly Leu Gly Gln Thr Ser Gln Glu Ser His 
    130                 135                 140 


