                         SEQUENCE LISTING

<110>  University of Virginia Patent Foundation
       Hunt, Donald F.
       Shabanowitz, Jeffrey
       D'Ippolito, Robert Anthony
       Panepinto, Maria C.
       Mahoney, Keira
 
<120>  MITIGATING THE CONCENTRATION EFFECTS OF BISPECIFIC ANTIBODY 
       DIGESTION WHEN USING AN IMMOBILIZED NONSPECIFIC PROTEASE TO 
       ACHIEVE COMPLETE SEQUENCE COVERAGE

<130>  3062/105 PCT

<150>  62/966,731
<151>  2020-01-28

<160>  30    

<170>  PatentIn version 3.3

<210>  1
<211>  394
<212>  PRT
<213>  Aspergillus saitoi

<400>  1

Met Val Val Phe Ser Lys Thr Ala Ala Leu Val Leu Gly Leu Ser Thr 
1               5                   10                  15      


Ala Val Ser Ala Ala Pro Ala Pro Thr Arg Lys Gly Phe Thr Ile Asn 
            20                  25                  30          


Gln Ile Ala Arg Pro Ala Asn Lys Thr Arg Thr Val Asn Leu Pro Gly 
        35                  40                  45              


Leu Tyr Ala Arg Ser Leu Ala Lys Phe Gly Gly Thr Val Pro Gln Ser 
    50                  55                  60                  


Val Lys Glu Ala Ala Ser Lys Gly Ser Ala Val Thr Thr Pro Gln Asn 
65                  70                  75                  80  


Asn Asp Glu Glu Tyr Leu Thr Pro Val Thr Val Gly Lys Ser Thr Leu 
                85                  90                  95      


His Leu Asp Phe Asp Thr Gly Ser Ala Asp Leu Trp Val Phe Ser Asp 
            100                 105                 110         


Glu Leu Pro Ser Ser Glu Gln Thr Gly His Asp Leu Tyr Thr Pro Ser 
        115                 120                 125             


Ser Ser Ala Thr Lys Leu Ser Gly Tyr Ser Trp Asp Ile Ser Tyr Gly 
    130                 135                 140                 


Asp Gly Ser Ser Ala Ser Gly Asp Val Tyr Arg Asp Thr Val Thr Val 
145                 150                 155                 160 


Gly Gly Val Thr Thr Asn Lys Gln Ala Val Glu Ala Ala Ser Lys Ile 
                165                 170                 175     


Ser Ser Glu Phe Val Gln Asp Thr Ala Asn Asp Gly Leu Leu Gly Leu 
            180                 185                 190         


Ala Phe Ser Ser Ile Asn Thr Val Gln Pro Lys Ala Gln Thr Thr Phe 
        195                 200                 205             


Phe Asp Thr Val Lys Ser Gln Leu Asp Ser Pro Leu Phe Ala Val Gln 
    210                 215                 220                 


Leu Lys His Asp Ala Pro Gly Val Tyr Asp Phe Gly Tyr Ile Asp Asp 
225                 230                 235                 240 


Ser Lys Tyr Thr Gly Ser Ile Thr Tyr Thr Asp Ala Asp Ser Ser Gln 
                245                 250                 255     


Gly Tyr Trp Gly Phe Ser Thr Asp Gly Tyr Ser Ile Gly Asp Gly Ser 
            260                 265                 270         


Ser Ser Ser Ser Gly Phe Ser Ala Ile Ala Asp Thr Gly Thr Thr Leu 
        275                 280                 285             


Ile Leu Leu Asp Asp Glu Ile Val Ser Ala Tyr Tyr Glu Gln Val Ser 
    290                 295                 300                 


Gly Ala Gln Glu Ser Tyr Glu Ala Gly Gly Tyr Val Phe Ser Cys Ser 
305                 310                 315                 320 


Thr Asp Leu Pro Asp Phe Thr Val Val Ile Gly Asp Tyr Lys Ala Val 
                325                 330                 335     


Val Pro Gly Lys Tyr Ile Asn Tyr Ala Pro Val Ser Thr Gly Ser Ser 
            340                 345                 350         


Thr Cys Tyr Gly Gly Ile Gln Ser Asn Ser Gly Leu Gly Leu Ser Ile 
        355                 360                 365             


Leu Gly Asp Val Phe Leu Lys Ser Gln Tyr Val Val Phe Asn Ser Glu 
    370                 375                 380                 


Gly Pro Lys Leu Gly Phe Ala Ala Gln Ala 
385                 390                 


<210>  2
<211>  10
<212>  PRT
<213>  Equus caballus

<400>  2

Phe Asp Lys Phe Lys His Leu Lys Thr Glu 
1               5                   10  


<210>  3
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  3

Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn 
1               5                   10                  15      


Gln Lys Asn Tyr 
            20  


<210>  4
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  4

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  5
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  5

Gly Gly Gly Gly Ser 
1               5   


<210>  6
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  6

Ser Gly Gly Ser Gly Gly Ser Gly Gly 
1               5                   


<210>  7
<211>  510
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  7

Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
    130                 135                 140                 


Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn 
145                 150                 155                 160 


Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Asp Ile Phe Pro Gly Ser Gly Asn Ile His Tyr Asn Glu Lys 
            180                 185                 190         


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
        195                 200                 205             


Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Val 
                245                 250                 255     


Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala 
            260                 265                 270         


Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Asn Asn Gly Asn 
        275                 280                 285             


Thr Tyr Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Ser 
    290                 295                 300                 


Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe 
305                 310                 315                 320 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val 
                325                 330                 335     


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gly Gln Gly Thr Gln Tyr 
            340                 345                 350         


Pro Phe Thr Phe Gly Ser Gly Thr Lys Val Glu Ile Lys Gly Glu Gly 
        355                 360                 365             


Thr Ser Thr Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ala Asp Gln 
    370                 375                 380                 


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
385                 390                 395                 400 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Lys Ala Trp 
                405                 410                 415     


Met His Trp Val Arg Gln Ala Pro Gly Lys Gln Leu Glu Trp Val Ala 
            420                 425                 430         


Gln Ile Lys Asp Lys Ser Asn Ser Tyr Ala Thr Tyr Tyr Ala Asp Ser 
        435                 440                 445             


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu 
    450                 455                 460                 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
465                 470                 475                 480 


Cys Arg Gly Val Tyr Tyr Ala Leu Ser Pro Phe Asp Tyr Trp Gly Gln 
                485                 490                 495     


Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
            500                 505                 510 


<210>  8
<211>  33
<212>  PRT
<213>  Oncorhynchus sp.

<400>  8

Met Pro Arg Arg Arg Arg Ser Ser Ser Arg Pro Val Arg Arg Arg Arg 
1               5                   10                  15      


Arg Pro Arg Val Ser Arg Arg Arg Arg Arg Arg Gly Gly Arg Arg Arg 
            20                  25                  30          


Arg 
    


<210>  9
<211>  32
<212>  PRT
<213>  Oncorhynchus sp.

<400>  9

Pro Arg Arg Arg Arg Arg Ser Ser Ser Arg Pro Ile Arg Arg Arg Arg 
1               5                   10                  15      


Arg Pro Arg Ala Ser Arg Arg Arg Arg Arg Gly Gly Arg Arg Arg Arg 
            20                  25                  30          


<210>  10
<211>  32
<212>  PRT
<213>  Oncorhynchus sp.

<400>  10

Pro Arg Arg Arg Arg Ser Ser Arg Arg Pro Val Arg Arg Arg Arg Arg 
1               5                   10                  15      


Pro Arg Val Ser Arg Arg Arg Arg Arg Arg Gly Gly Arg Arg Arg Arg 
            20                  25                  30          


<210>  11
<211>  32
<212>  PRT
<213>  Oncorhynchus sp.

<400>  11

Pro Arg Arg Arg Arg Ser Ser Ser Arg Pro Val Arg Arg Arg Arg Arg 
1               5                   10                  15      


Pro Arg Val Ser Arg Arg Arg Arg Arg Arg Gly Gly Arg Arg Arg Arg 
            20                  25                  30          


<210>  12
<211>  30
<212>  PRT
<213>  Oncorhynchus sp.

<400>  12

Pro Arg Arg Arg Arg Ala Ser Arg Arg Ile Arg Arg Arg Arg Arg Pro 
1               5                   10                  15      


Arg Val Ser Arg Arg Arg Arg Arg Gly Gly Arg Arg Arg Arg 
            20                  25                  30  


<210>  13
<211>  10
<212>  PRT
<213>  Equus caballus

<400>  13

Phe Asp Lys Phe Lys His Leu Lys Thr Glu 
1               5                   10  


<210>  14
<211>  11
<212>  PRT
<213>  Equus caballus

<400>  14

Leu Phe Thr Gly His Pro Glu Thr Leu Glu Lys 
1               5                   10      


<210>  15
<211>  38
<212>  PRT
<213>  Equus caballus

<400>  15

Leu Phe Thr Gly His Pro Glu Thr Leu Glu Lys Phe Asp Lys Phe Lys 
1               5                   10                  15      


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
            20                  25                  30          


His Gly Thr Val Val Leu 
        35              


<210>  16
<211>  31
<212>  PRT
<213>  Equus caballus

<400>  16

Ile Ser Asp Ala Ile Ile His Val Leu His Ser Lys His Pro Gly Asp 
1               5                   10                  15      


Phe Gly Ala Asp Ala Gln Gly Ala Met Thr Lys Ala Leu Glu Leu 
            20                  25                  30      


<210>  17
<211>  35
<212>  PRT
<213>  Equus caballus

<400>  17

Ile Ser Asp Ala Ile Ile His Val Leu His Ser Lys His Pro Gly Asp 
1               5                   10                  15      


Phe Gly Ala Asp Ala Gln Gly Ala Met Thr Lys Ala Leu Glu Leu Phe 
            20                  25                  30          


Arg Asn Asp 
        35  


<210>  18
<211>  37
<212>  PRT
<213>  Equus caballus

<400>  18

Glu Phe Ile Ser Asp Ala Ile Ile His Val Leu His Ser Lys His Pro 
1               5                   10                  15      


Gly Asp Phe Gly Ala Asp Ala Gln Gly Ala Met Thr Lys Ala Leu Glu 
            20                  25                  30          


Leu Phe Arg Asn Asp 
        35          


<210>  19
<211>  47
<212>  PRT
<213>  Equus caballus

<400>  19

Ile Ser Asp Ala Ile Ile His Val Leu His Ser Lys His Pro Gly Asp 
1               5                   10                  15      


Phe Gly Ala Asp Ala Gln Gly Ala Met Thr Lys Ala Leu Glu Leu Phe 
            20                  25                  30          


Arg Asn Asp Ile Ala Ala Lys Tyr Lys Glu Leu Gly Phe Gln Gly 
        35                  40                  45          


<210>  20
<211>  49
<212>  PRT
<213>  Equus caballus

<400>  20

Glu Phe Ile Ser Asp Ala Ile Ile His Val Leu His Ser Lys His Pro 
1               5                   10                  15      


Gly Asp Phe Gly Ala Asp Ala Gln Gly Ala Met Thr Lys Ala Leu Glu 
            20                  25                  30          


Leu Phe Arg Asn Asp Ile Ala Ala Lys Tyr Lys Glu Leu Gly Phe Gln 
        35                  40                  45              


Gly 
    


<210>  21
<211>  86
<212>  PRT
<213>  Equus caballus

<400>  21

Thr Ala Leu Gly Gly Ile Leu Leu Lys Lys Lys Gly His His Glu Ala 
1               5                   10                  15      


Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr Lys His Lys Ile Pro 
            20                  25                  30          


Ile Lys Tyr Leu Glu Phe Ile Ser Asp Ala Ile Ile His Val Leu His 
        35                  40                  45              


Ser Lys His Pro Gly Asp Phe Ala Gly Ala Asp Ala Gln Gly Ala Met 
    50                  55                  60                  


Thr Lys Ala Leu Glu Leu Phe Arg Asn Asp Ile Ala Ala Lys Tyr Lys 
65                  70                  75                  80  


Glu Leu Gly Phe Gln Gly 
                85      


<210>  22
<211>  31
<212>  PRT
<213>  Equus caballus

<400>  22

Gly Leu Ser Asp Gly Glu Trp Gln Gln Val Leu Asn Val Trp Gly Lys 
1               5                   10                  15      


Val Glu Ala Asp Ile Ala Gly His Gly Gln Glu Val Leu Ile Arg 
            20                  25                  30      


<210>  23
<211>  69
<212>  PRT
<213>  Equus caballus

<400>  23

Gly Leu Ser Asp Gly Glu Trp Gln Gln Val Leu Asn Val Trp Gly Lys 
1               5                   10                  15      


Val Glu Ala Asp Ile Ala Gly His Gly Gln Glu Val Leu Ile Arg Leu 
            20                  25                  30          


Phe Thr Gly His Pro Glu Thr Leu Glu Lys Phe Asp Lys Phe Lys His 
        35                  40                  45              


Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys His 
    50                  55                  60                  


Gly Thr Val Val Leu 
65                  


<210>  24
<211>  42
<212>  PRT
<213>  Equus caballus

<400>  24

Gly Leu Ser Asp Gly Glu Trp Gln Gln Val Leu Asn Val Trp Gly Lys 
1               5                   10                  15      


Val Glu Ala Asp Ile Ala Gly His Gly Gln Glu Val Leu Ile Arg Leu 
            20                  25                  30          


Phe Thr Gly His Pro Glu Thr Leu Glu Lys 
        35                  40          


<210>  25
<211>  214
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Arg Asn Ile Glu Arg Gln 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Glu Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Arg Lys Glu Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asp Pro Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  26
<211>  239
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  26

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Tyr 
            20                  25                  30          


Asp Ile Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Pro Ser Gly Gln Ser Thr Tyr Tyr Arg Arg Glu Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Thr Gly Arg Glu Tyr Gly Gly Gly Trp Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
225                 230                 235                 


<210>  27
<211>  209
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  27

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
1               5                   10                  15      


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            20                  25                  30          


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        35                  40                  45              


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    50                  55                  60                  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
65                  70                  75                  80  


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                85                  90                  95      


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            100                 105                 110         


Tyr Thr Leu Pro Pro Ser Gln Lys Glu Met Thr Lys Asn Gln Val Ser 
        115                 120                 125             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    130                 135                 140                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
145                 150                 155                 160 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                165                 170                 175     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            180                 185                 190         


His Glu Ala Leu His Asn Arg Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        195                 200                 205             


Pro 
    


<210>  28
<211>  235
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  28

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asn 
            20                  25                  30          


Asn Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Asn Thr Arg Ser Gly Gly Ser Ile Tyr Asn Glu Glu Phe 
    50                  55                  60                  


Gln Asp Arg Val Ile Met Thr Val Asp Lys Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr His Cys 
                85                  90                  95      


Ala Arg Arg Lys Ser Tyr Gly Tyr Tyr Leu Asp Glu Trp Gly Glu Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
225                 230                 235 


<210>  29
<211>  209
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  29

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
1               5                   10                  15      


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            20                  25                  30          


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        35                  40                  45              


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    50                  55                  60                  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
65                  70                  75                  80  


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                85                  90                  95      


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            100                 105                 110         


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
        115                 120                 125             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    130                 135                 140                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
145                 150                 155                 160 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                165                 170                 175     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            180                 185                 190         


His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser Leu Ser 
        195                 200                 205             


Pro 
    


<210>  30
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  30

Leu Ala Val Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr Phe 
1               5                   10                  15      


Gly Ala Gly Thr Lys 
            20      


