                               SEQUENCE LISTING

<110> THE CHILDREN'S MEDICAL CENTER CORPORATION
 
<120> ANAPLASTIC LYMPHOMA KINASE CHIMERIC ANTIGEN RECEPTORS AND METHODS
      OF USE

<130> 167705.020501/PCT

<140> PCT/US2021/015519
<141> 2021-01-28

<150> 62/966,748
<151> 2020-01-28

<160> 119   

<170> PatentIn version 3.5

<210> 1
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1
Gly Gly Gly Gly Ser 
1               5   


<210> 2
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Ser Tyr Trp Met Asn 
1               5   


<210> 3
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 4
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Tyr Tyr Tyr Gly Ser Lys Ala Tyr 
1               5               


<210> 5
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Arg Ala Ser Glu Asn Ile Tyr Tyr Ser Leu Ala 
1               5                   10      


<210> 6
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Asn Ala Asn Ser Leu Glu Asp 
1               5           


<210> 7
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Lys Gln Ala Tyr Asp Val Pro Phe Thr 
1               5                   


<210> 8
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Ser Tyr Trp Met His 
1               5   


<210> 9
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Arg Ile Asp Pro Asn Ser Gly Gly Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210> 10
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Asp Tyr Tyr Gly Ser Ser Tyr Arg Phe Ala Tyr 
1               5                   10      


<210> 11
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Ser Val Ser Gln Gly Ile Ser Asn Ser Leu Asn 
1               5                   10      


<210> 12
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Tyr Thr Ser Ser Leu His Ser 
1               5           


<210> 13
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Gln Gln Tyr Ser Lys Leu Pro Leu Thr 
1               5                   


<210> 14
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Asn Tyr Trp Met His 
1               5   


<210> 15
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Lys Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210> 16
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Asp Tyr Tyr Gly Ser Ser Ser Trp Phe Ala Tyr 
1               5                   10      


<210> 17
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala 
1               5                   10      


<210> 18
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210> 19
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Gln Gln Tyr Asn Ser Tyr Pro Tyr Met Tyr Thr 
1               5                   10      


<210> 20
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Ser Tyr Trp Val Asn 
1               5   


<210> 21
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Ser Arg Gly Tyr Phe Tyr Gly Ser Thr Tyr Asp Ser 
1               5                   10          


<210> 22
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn 
1               5                   10                  15  


<210> 23
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Ala Ala Ser Asn Gln Gly Ser 
1               5           


<210> 24
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Gln Gln Ser Lys Glu Val Pro Trp Thr 
1               5                   


<210> 25
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Tyr Ile Lys Pro Ser Ser Gly Tyr Thr Lys Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210> 26
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Ser Tyr Ala Met Ser 
1               5   


<210> 27
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Tyr Ile Ser Ser Gly Gly Asp Tyr Ile Tyr Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210> 28
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Glu Arg Ile Trp Leu Arg Arg Phe Phe Asp Val 
1               5                   10      


<210> 29
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Lys Ala Ser Gln Asn Val Gly Thr Ala Val Ala 
1               5                   10      


<210> 30
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Ser Ala Ser Asn Arg Phe Thr 
1               5           


<210> 31
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Gln Gln Tyr Ser Ser Tyr Pro Leu Thr 
1               5                   


<210> 32
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Gln Arg Tyr Asn Ser Tyr Pro Tyr Met Phe Thr 
1               5                   10      


<210> 33
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ser Tyr Tyr Tyr Gly Ser Lys Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210> 34
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ala Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Tyr Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Ser Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Met Lys Ile Asn Ser Met Gln Pro 
65                  70                  75                  80  


Glu Asp Thr Ala Thr Tyr Phe Cys Lys Gln Ala Tyr Asp Val Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210> 35
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Phe Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Asn Ser Gly Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Pro Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Tyr Arg Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210> 36
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Ala Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Val Ser Gln Gly Ile Ser Asn Ser 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210> 37
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Lys Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Tyr Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Ser Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210> 38
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Asp Ile Val Met Thr Gln Ser Gln Arg Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Val Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Met Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110 


<210> 39
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Val Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Arg Gly Tyr Phe Tyr Gly Ser Thr Tyr Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210> 40
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210> 41
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 41
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Lys Pro Ser Ser Gly Tyr Thr Lys Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Tyr Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Ser Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210> 42
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Asp Ile Val Met Thr Gln Ser Gln Arg Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Met Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110 


<210> 43
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
Asp Val Lys Leu Val Glu Ser Gly Glu Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Thr Tyr Ile Ser Ser Gly Gly Asp Tyr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Arg Ile Trp Leu Arg Arg Phe Phe Asp Val Trp Gly Thr 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210> 44
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Leu Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Phe Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210> 45
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Lys Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Ser Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210> 46
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly His Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Arg Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Met Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110 


<210> 47
<211> 1626
<212> PRT
<213> Homo sapiens

<400> 47
Thr Ala Ser Ser Gly Gly Met Gly Ala Ile Gly Leu Leu Trp Leu Leu 
1               5                   10                  15      


Pro Leu Leu Leu Ser Thr Ala Ala Val Gly Ser Gly Met Gly Thr Gly 
            20                  25                  30          


Gln Arg Ala Gly Ser Pro Ala Ala Gly Pro Pro Leu Gln Pro Arg Glu 
        35                  40                  45              


Pro Leu Ser Tyr Ser Arg Leu Gln Arg Lys Ser Leu Ala Val Asp Phe 
    50                  55                  60                  


Val Val Pro Ser Leu Phe Arg Val Tyr Ala Arg Asp Leu Leu Leu Pro 
65                  70                  75                  80  


Pro Ser Ser Ser Glu Leu Lys Ala Gly Arg Pro Glu Ala Arg Gly Ser 
                85                  90                  95      


Leu Ala Leu Asp Cys Ala Pro Leu Leu Arg Leu Leu Gly Pro Ala Pro 
            100                 105                 110         


Gly Val Ser Trp Thr Ala Gly Ser Pro Ala Pro Ala Glu Ala Arg Thr 
        115                 120                 125             


Leu Ser Arg Val Leu Lys Gly Gly Ser Val Arg Lys Leu Arg Arg Ala 
    130                 135                 140                 


Lys Gln Leu Val Leu Glu Leu Gly Glu Glu Ala Ile Leu Glu Gly Cys 
145                 150                 155                 160 


Val Gly Pro Pro Gly Glu Ala Ala Val Gly Leu Leu Gln Phe Asn Leu 
                165                 170                 175     


Ser Glu Leu Phe Ser Trp Trp Ile Arg Gln Gly Glu Gly Arg Leu Arg 
            180                 185                 190         


Ile Arg Leu Met Pro Glu Lys Lys Ala Ser Glu Val Gly Arg Glu Gly 
        195                 200                 205             


Arg Leu Ser Ala Ala Ile Arg Ala Ser Gln Pro Arg Leu Leu Phe Gln 
    210                 215                 220                 


Ile Phe Gly Thr Gly His Ser Ser Leu Glu Ser Pro Thr Asn Met Pro 
225                 230                 235                 240 


Ser Pro Ser Pro Asp Tyr Phe Thr Trp Asn Leu Thr Trp Ile Met Lys 
                245                 250                 255     


Asp Ser Phe Pro Phe Leu Ser His Arg Ser Arg Tyr Gly Leu Glu Cys 
            260                 265                 270         


Ser Phe Asp Phe Pro Cys Glu Leu Glu Tyr Ser Pro Pro Leu His Asp 
        275                 280                 285             


Leu Arg Asn Gln Ser Trp Ser Trp Arg Arg Ile Pro Ser Glu Glu Ala 
    290                 295                 300                 


Ser Gln Met Asp Leu Leu Asp Gly Pro Gly Ala Glu Arg Ser Lys Glu 
305                 310                 315                 320 


Met Pro Arg Gly Ser Phe Leu Leu Leu Asn Thr Ser Ala Asp Ser Lys 
                325                 330                 335     


His Thr Ile Leu Ser Pro Trp Met Arg Ser Ser Ser Glu His Cys Thr 
            340                 345                 350         


Leu Ala Val Ser Val His Arg His Leu Gln Pro Ser Gly Arg Tyr Ile 
        355                 360                 365             


Ala Gln Leu Leu Pro His Asn Glu Ala Ala Arg Glu Ile Leu Leu Met 
    370                 375                 380                 


Pro Thr Pro Gly Lys His Gly Trp Thr Val Leu Gln Gly Arg Ile Gly 
385                 390                 395                 400 


Arg Pro Asp Asn Pro Phe Arg Val Ala Leu Glu Tyr Ile Ser Ser Gly 
                405                 410                 415     


Asn Arg Ser Leu Ser Ala Val Asp Phe Phe Ala Leu Lys Asn Cys Ser 
            420                 425                 430         


Glu Gly Thr Ser Pro Gly Ser Lys Met Ala Leu Gln Ser Ser Phe Thr 
        435                 440                 445             


Cys Trp Asn Gly Thr Val Leu Gln Leu Gly Gln Ala Cys Asp Phe His 
    450                 455                 460                 


Gln Asp Cys Ala Gln Gly Glu Asp Glu Ser Gln Met Cys Arg Lys Leu 
465                 470                 475                 480 


Pro Val Gly Phe Tyr Cys Asn Phe Glu Asp Gly Phe Cys Gly Trp Thr 
                485                 490                 495     


Gln Gly Thr Leu Ser Pro His Thr Pro Gln Trp Gln Val Arg Thr Leu 
            500                 505                 510         


Lys Asp Ala Arg Phe Gln Asp His Gln Asp His Ala Leu Leu Leu Ser 
        515                 520                 525             


Thr Thr Asp Val Pro Ala Ser Glu Ser Ala Thr Val Thr Ser Ala Thr 
    530                 535                 540                 


Phe Pro Ala Pro Ile Lys Ser Ser Pro Cys Glu Leu Arg Met Ser Trp 
545                 550                 555                 560 


Leu Ile Arg Gly Val Leu Arg Gly Asn Val Ser Leu Val Leu Val Glu 
                565                 570                 575     


Asn Lys Thr Gly Lys Glu Gln Gly Arg Met Val Trp His Val Ala Ala 
            580                 585                 590         


Tyr Glu Gly Leu Ser Leu Trp Gln Trp Met Val Leu Pro Leu Leu Asp 
        595                 600                 605             


Val Ser Asp Arg Phe Trp Leu Gln Met Val Ala Trp Trp Gly Gln Gly 
    610                 615                 620                 


Ser Arg Ala Ile Val Ala Phe Asp Asn Ile Ser Ile Ser Leu Asp Cys 
625                 630                 635                 640 


Tyr Leu Thr Ile Ser Gly Glu Asp Lys Ile Leu Gln Asn Thr Ala Pro 
                645                 650                 655     


Lys Ser Arg Asn Leu Phe Glu Arg Asn Pro Asn Lys Glu Leu Lys Pro 
            660                 665                 670         


Gly Glu Asn Ser Pro Arg Gln Thr Pro Ile Phe Asp Pro Thr Val His 
        675                 680                 685             


Trp Leu Phe Thr Thr Cys Gly Ala Ser Gly Pro His Gly Pro Thr Gln 
    690                 695                 700                 


Ala Gln Cys Asn Asn Ala Tyr Gln Asn Ser Asn Leu Ser Val Glu Val 
705                 710                 715                 720 


Gly Ser Glu Gly Pro Leu Lys Gly Ile Gln Ile Trp Lys Val Pro Ala 
                725                 730                 735     


Thr Asp Thr Tyr Ser Ile Ser Gly Tyr Gly Ala Ala Gly Gly Lys Gly 
            740                 745                 750         


Gly Lys Asn Thr Met Met Arg Ser His Gly Val Ser Val Leu Gly Ile 
        755                 760                 765             


Phe Asn Leu Glu Lys Asp Asp Met Leu Tyr Ile Leu Val Gly Gln Gln 
    770                 775                 780                 


Gly Glu Asp Ala Cys Pro Ser Thr Asn Gln Leu Ile Gln Lys Val Cys 
785                 790                 795                 800 


Ile Gly Glu Asn Asn Val Ile Glu Glu Glu Ile Arg Val Asn Arg Ser 
                805                 810                 815     


Val His Glu Trp Ala Gly Gly Gly Gly Gly Gly Gly Gly Ala Thr Tyr 
            820                 825                 830         


Val Phe Lys Met Lys Asp Gly Val Pro Val Pro Leu Ile Ile Ala Ala 
        835                 840                 845             


Gly Gly Gly Gly Arg Ala Tyr Gly Ala Lys Thr Asp Thr Phe His Pro 
    850                 855                 860                 


Glu Arg Leu Glu Asn Asn Ser Ser Val Leu Gly Leu Asn Gly Asn Ser 
865                 870                 875                 880 


Gly Ala Ala Gly Gly Gly Gly Gly Trp Asn Asp Asn Thr Ser Leu Leu 
                885                 890                 895     


Trp Ala Gly Lys Ser Leu Gln Glu Gly Ala Thr Gly Gly His Ser Cys 
            900                 905                 910         


Pro Gln Ala Met Lys Lys Trp Gly Trp Glu Thr Arg Gly Gly Phe Gly 
        915                 920                 925             


Gly Gly Gly Gly Gly Cys Ser Ser Gly Gly Gly Gly Gly Gly Tyr Ile 
    930                 935                 940                 


Gly Gly Asn Ala Ala Ser Asn Asn Asp Pro Glu Met Asp Gly Glu Asp 
945                 950                 955                 960 


Gly Val Ser Phe Ile Ser Pro Leu Gly Ile Leu Tyr Thr Pro Ala Leu 
                965                 970                 975     


Lys Val Met Glu Gly His Gly Glu Val Asn Ile Lys His Tyr Leu Asn 
            980                 985                 990         


Cys Ser His Cys Glu Val Asp Glu  Cys His Met Asp Pro  Glu Ser His 
        995                 1000                 1005             


Lys Val  Ile Cys Phe Cys Asp  His Gly Thr Val Leu  Ala Glu Asp 
    1010                 1015                 1020             


Gly Val  Ser Cys Ile Val Ser  Pro Thr Pro Glu Pro  His Leu Pro 
    1025                 1030                 1035             


Leu Ser  Leu Ile Leu Ser Val  Val Thr Ser Ala Leu  Val Ala Ala 
    1040                 1045                 1050             


Leu Val  Leu Ala Phe Ser Gly  Ile Met Ile Val Tyr  Arg Arg Lys 
    1055                 1060                 1065             


His Gln  Glu Leu Gln Ala Met  Gln Met Glu Leu Gln  Ser Pro Glu 
    1070                 1075                 1080             


Tyr Lys  Leu Ser Lys Leu Arg  Thr Ser Thr Ile Met  Thr Asp Tyr 
    1085                 1090                 1095             


Asn Pro  Asn Tyr Cys Phe Ala  Gly Lys Thr Ser Ser  Ile Ser Asp 
    1100                 1105                 1110             


Leu Lys  Glu Val Pro Arg Lys  Asn Ile Thr Leu Ile  Arg Gly Leu 
    1115                 1120                 1125             


Gly His  Gly Ala Phe Gly Glu  Val Tyr Glu Gly Gln  Val Ser Gly 
    1130                 1135                 1140             


Met Pro  Asn Asp Pro Ser Pro  Leu Gln Val Ala Val  Lys Thr Leu 
    1145                 1150                 1155             


Pro Glu  Val Cys Ser Glu Gln  Asp Glu Leu Asp Phe  Leu Met Glu 
    1160                 1165                 1170             


Ala Leu  Ile Ile Ser Lys Phe  Asn His Gln Asn Ile  Val Arg Cys 
    1175                 1180                 1185             


Ile Gly  Val Ser Leu Gln Ser  Leu Pro Arg Phe Ile  Leu Leu Glu 
    1190                 1195                 1200             


Leu Met  Ala Gly Gly Asp Leu  Lys Ser Phe Leu Arg  Glu Thr Arg 
    1205                 1210                 1215             


Pro Arg  Pro Ser Gln Pro Ser  Ser Leu Ala Met Leu  Asp Leu Leu 
    1220                 1225                 1230             


His Val  Ala Arg Asp Ile Ala  Cys Gly Cys Gln Tyr  Leu Glu Glu 
    1235                 1240                 1245             


Asn His  Phe Ile His Arg Asp  Ile Ala Ala Arg Asn  Cys Leu Leu 
    1250                 1255                 1260             


Thr Cys  Pro Gly Pro Gly Arg  Val Ala Lys Ile Gly  Asp Phe Gly 
    1265                 1270                 1275             


Met Ala  Arg Asp Ile Tyr Arg  Ala Ser Tyr Tyr Arg  Lys Gly Gly 
    1280                 1285                 1290             


Cys Ala  Met Leu Pro Val Lys  Trp Met Pro Pro Glu  Ala Phe Met 
    1295                 1300                 1305             


Glu Gly  Ile Phe Thr Ser Lys  Thr Asp Thr Trp Ser  Phe Gly Val 
    1310                 1315                 1320             


Leu Leu  Trp Glu Ile Phe Ser  Leu Gly Tyr Met Pro  Tyr Pro Ser 
    1325                 1330                 1335             


Lys Ser  Asn Gln Glu Val Leu  Glu Phe Val Thr Ser  Gly Gly Arg 
    1340                 1345                 1350             


Met Asp  Pro Pro Lys Asn Cys  Pro Gly Pro Val Tyr  Arg Ile Met 
    1355                 1360                 1365             


Thr Gln  Cys Trp Gln His Gln  Pro Glu Asp Arg Pro  Asn Phe Ala 
    1370                 1375                 1380             


Ile Ile  Leu Glu Arg Ile Glu  Tyr Cys Thr Gln Asp  Pro Asp Val 
    1385                 1390                 1395             


Ile Asn  Thr Ala Leu Pro Ile  Glu Tyr Gly Pro Leu  Val Glu Glu 
    1400                 1405                 1410             


Glu Glu  Lys Val Pro Val Arg  Pro Lys Asp Pro Glu  Gly Val Pro 
    1415                 1420                 1425             


Pro Leu  Leu Val Ser Gln Gln  Ala Lys Arg Glu Glu  Glu Arg Ser 
    1430                 1435                 1440             


Pro Ala  Ala Pro Pro Pro Leu  Pro Thr Thr Ser Ser  Gly Lys Ala 
    1445                 1450                 1455             


Ala Lys  Lys Pro Thr Ala Ala  Glu Ile Ser Val Arg  Val Pro Arg 
    1460                 1465                 1470             


Gly Pro  Ala Val Glu Gly Gly  His Val Asn Met Ala  Phe Ser Gln 
    1475                 1480                 1485             


Ser Asn  Pro Pro Ser Glu Leu  His Lys Val His Gly  Ser Arg Asn 
    1490                 1495                 1500             


Lys Pro  Thr Ser Leu Trp Asn  Pro Thr Tyr Gly Ser  Trp Phe Thr 
    1505                 1510                 1515             


Glu Lys  Pro Thr Lys Lys Asn  Asn Pro Ile Ala Lys  Lys Glu Pro 
    1520                 1525                 1530             


His Asp  Arg Gly Asn Leu Gly  Leu Glu Gly Ser Cys  Thr Val Pro 
    1535                 1540                 1545             


Pro Asn  Val Ala Thr Gly Arg  Leu Pro Gly Ala Ser  Leu Leu Leu 
    1550                 1555                 1560             


Glu Pro  Ser Ser Leu Thr Ala  Asn Met Lys Glu Val  Pro Leu Phe 
    1565                 1570                 1575             


Arg Leu  Arg His Phe Pro Cys  Gly Asn Val Asn Tyr  Gly Tyr Gln 
    1580                 1585                 1590             


Gln Gln  Gly Leu Pro Leu Glu  Ala Ala Thr Ala Pro  Gly Ala Gly 
    1595                 1600                 1605             


His Tyr  Glu Asp Thr Ile Leu  Lys Ser Lys Asn Ser  Met Asn Gln 
    1610                 1615                 1620             


Pro Gly  Pro 
    1625     


<210> 48
<211> 38
<212> PRT
<213> Homo sapiens

<400> 48
Gly Ala Ala Ala Val Val Ala Ala Gly Thr Ser Arg Arg Leu Cys Ser 
1               5                   10                  15      


Glu Gly Arg Gly Ala Pro Arg Cys Phe Pro Ala Ala Leu Trp Ser Ala 
            20                  25                  30          


Thr Gln Ser Arg Gly Arg 
        35              


<210> 49
<211> 70
<212> PRT
<213> Homo sapiens

<400> 49
Trp Val Arg Arg Gly Arg Gln Asp Phe Gly Arg Pro Cys Pro Glu Arg 
1               5                   10                  15      


Pro Gln Leu Leu Pro Pro Gly Pro Leu Gln Cys Leu Arg Thr Leu Arg 
            20                  25                  30          


Ser Arg Gly Ala Gly Glu Ser Lys Asp Ala Ala Asn Leu Arg Ser Ala 
        35                  40                  45              


Gly Ala Gly Ile His Ala Gln Lys Phe Ser Arg Gln Thr Val Arg Ser 
    50                  55                  60                  


Leu Pro Ala Ala Glu Arg 
65                  70  


<210> 50
<211> 45
<212> PRT
<213> Homo sapiens

<400> 50
Leu Glu Gly Ala Gln Asp Gly Ser Leu Arg Pro Arg Phe Pro Pro Arg 
1               5                   10                  15      


Pro Gly Arg Arg Ala Trp Arg Ser Gln Lys Glu Arg Lys Arg Arg Pro 
            20                  25                  30          


Gly Gln Arg Ala Ala Ala Gly Ser Arg Arg Ser Gln Pro 
        35                  40                  45  


<210> 51
<211> 63
<212> PRT
<213> Homo sapiens

<400> 51
Lys Leu Gln Arg Leu Glu Ala Ala Pro Arg Gly Asp Arg Pro Gln Leu 
1               5                   10                  15      


Arg Leu Arg Gly Ala Gly Glu Asp Gly Thr Gln Leu Pro Pro Pro Phe 
            20                  25                  30          


Asn His Ser Ser Ser Ser Val Pro Ser Ala Ala Ser Tyr Arg Arg Gly 
        35                  40                  45              


Arg Gly Thr Arg Arg Gly Glu Arg Glu Ala Gln Gly Pro Ser Gln 
    50                  55                  60              


<210> 52
<211> 4
<212> PRT
<213> Homo sapiens

<400> 52
Ala Gln Cys Ala 
1               


<210> 53
<211> 14
<212> PRT
<213> Homo sapiens

<400> 53
Val Ser Leu Asp Ser Pro Leu Ser Phe Gln Val Cys Phe Ile 
1               5                   10                  


<210> 54
<211> 46
<212> PRT
<213> Homo sapiens

<400> 54
Thr Pro Ala Arg Leu Arg Ala Val Gly Gly Lys Gln Glu Thr Cys Ala 
1               5                   10                  15      


His Ala Gln Ser Ser Gly Asp Gln Val Glu Gly Ala Ala Gly Tyr Gln 
            20                  25                  30          


Gly Leu Phe Arg Ala Ser Ser His Leu Gly Glu Ser Glu Gly 
        35                  40                  45      


<210> 55
<211> 7
<212> PRT
<213> Homo sapiens

<400> 55
Gly Trp Ala Arg Arg Ala Val 
1               5           


<210> 56
<211> 1626
<212> PRT
<213> Homo sapiens

<400> 56
Thr Ala Ser Ser Gly Gly Met Gly Ala Ile Gly Leu Leu Trp Leu Leu 
1               5                   10                  15      


Pro Leu Leu Leu Ser Thr Ala Ala Val Gly Ser Gly Met Gly Thr Gly 
            20                  25                  30          


Gln Arg Ala Gly Ser Pro Ala Ala Gly Pro Pro Leu Gln Pro Arg Glu 
        35                  40                  45              


Pro Leu Ser Tyr Ser Arg Leu Gln Arg Lys Ser Leu Ala Val Asp Phe 
    50                  55                  60                  


Val Val Pro Ser Leu Phe Arg Val Tyr Ala Arg Asp Leu Leu Leu Pro 
65                  70                  75                  80  


Pro Ser Ser Ser Glu Leu Lys Ala Gly Arg Pro Glu Ala Arg Gly Ser 
                85                  90                  95      


Leu Ala Leu Asp Cys Ala Pro Leu Leu Arg Leu Leu Gly Pro Ala Pro 
            100                 105                 110         


Gly Val Ser Trp Thr Ala Gly Ser Pro Ala Pro Ala Glu Ala Arg Thr 
        115                 120                 125             


Leu Ser Arg Val Leu Lys Gly Gly Ser Val Arg Lys Leu Arg Arg Ala 
    130                 135                 140                 


Lys Gln Leu Val Leu Glu Leu Gly Glu Glu Ala Ile Leu Glu Gly Cys 
145                 150                 155                 160 


Val Gly Pro Pro Gly Glu Ala Ala Val Gly Leu Leu Gln Phe Asn Leu 
                165                 170                 175     


Ser Glu Leu Phe Ser Trp Trp Ile Arg Gln Gly Glu Gly Arg Leu Arg 
            180                 185                 190         


Ile Arg Leu Met Pro Glu Lys Lys Ala Ser Glu Val Gly Arg Glu Gly 
        195                 200                 205             


Arg Leu Ser Ala Ala Ile Arg Ala Ser Gln Pro Arg Leu Leu Phe Gln 
    210                 215                 220                 


Ile Phe Gly Thr Gly His Ser Ser Leu Glu Ser Pro Thr Asn Met Pro 
225                 230                 235                 240 


Ser Pro Ser Pro Asp Tyr Phe Thr Trp Asn Leu Thr Trp Ile Met Lys 
                245                 250                 255     


Asp Ser Phe Pro Phe Leu Ser His Arg Ser Arg Tyr Gly Leu Glu Cys 
            260                 265                 270         


Ser Phe Asp Phe Pro Cys Glu Leu Glu Tyr Ser Pro Pro Leu His Asp 
        275                 280                 285             


Leu Arg Asn Gln Ser Trp Ser Trp Arg Arg Ile Pro Ser Glu Glu Ala 
    290                 295                 300                 


Ser Gln Met Asp Leu Leu Asp Gly Pro Gly Ala Glu Arg Ser Lys Glu 
305                 310                 315                 320 


Met Pro Arg Gly Ser Phe Leu Leu Leu Asn Thr Ser Ala Asp Ser Lys 
                325                 330                 335     


His Thr Ile Leu Ser Pro Trp Met Arg Ser Ser Ser Glu His Cys Thr 
            340                 345                 350         


Leu Ala Val Ser Val His Arg His Leu Gln Pro Ser Gly Arg Tyr Ile 
        355                 360                 365             


Ala Gln Leu Leu Pro His Asn Glu Ala Ala Arg Glu Ile Leu Leu Met 
    370                 375                 380                 


Pro Thr Pro Gly Lys His Gly Trp Thr Val Leu Gln Gly Arg Ile Gly 
385                 390                 395                 400 


Arg Pro Asp Asn Pro Phe Arg Val Ala Leu Glu Tyr Ile Ser Ser Gly 
                405                 410                 415     


Asn Arg Ser Leu Ser Ala Val Asp Phe Phe Ala Leu Lys Asn Cys Ser 
            420                 425                 430         


Glu Gly Thr Ser Pro Gly Ser Lys Met Ala Leu Gln Ser Ser Phe Thr 
        435                 440                 445             


Cys Trp Asn Gly Thr Val Leu Gln Leu Gly Gln Ala Cys Asp Phe His 
    450                 455                 460                 


Gln Asp Cys Ala Gln Gly Glu Asp Glu Ser Gln Met Cys Arg Lys Leu 
465                 470                 475                 480 


Pro Val Gly Phe Tyr Cys Asn Phe Glu Asp Gly Phe Cys Gly Trp Thr 
                485                 490                 495     


Gln Gly Thr Leu Ser Pro His Thr Pro Gln Trp Gln Val Arg Thr Leu 
            500                 505                 510         


Lys Asp Ala Arg Phe Gln Asp His Gln Asp His Ala Leu Leu Leu Ser 
        515                 520                 525             


Thr Thr Asp Val Pro Ala Ser Glu Ser Ala Thr Val Thr Ser Ala Thr 
    530                 535                 540                 


Phe Pro Ala Pro Ile Lys Ser Ser Pro Cys Glu Leu Arg Met Ser Trp 
545                 550                 555                 560 


Leu Ile Arg Gly Val Leu Arg Gly Asn Val Ser Leu Val Leu Val Glu 
                565                 570                 575     


Asn Lys Thr Gly Lys Glu Gln Gly Arg Met Val Trp His Val Ala Ala 
            580                 585                 590         


Tyr Glu Gly Leu Ser Leu Trp Gln Trp Met Val Leu Pro Leu Leu Asp 
        595                 600                 605             


Val Ser Asp Arg Phe Trp Leu Gln Met Val Ala Trp Trp Gly Gln Gly 
    610                 615                 620                 


Ser Arg Ala Ile Val Ala Phe Asp Asn Ile Ser Ile Ser Leu Asp Cys 
625                 630                 635                 640 


Tyr Leu Thr Ile Ser Gly Glu Asp Lys Ile Leu Gln Asn Thr Ala Pro 
                645                 650                 655     


Lys Ser Arg Asn Leu Phe Glu Arg Asn Pro Asn Lys Glu Leu Lys Pro 
            660                 665                 670         


Gly Glu Asn Ser Pro Arg Gln Thr Pro Ile Phe Asp Pro Thr Val His 
        675                 680                 685             


Trp Leu Phe Thr Thr Cys Gly Ala Ser Gly Pro His Gly Pro Thr Gln 
    690                 695                 700                 


Ala Gln Cys Asn Asn Ala Tyr Gln Asn Ser Asn Leu Ser Val Glu Val 
705                 710                 715                 720 


Gly Ser Glu Gly Pro Leu Lys Gly Ile Gln Ile Trp Lys Val Pro Ala 
                725                 730                 735     


Thr Asp Thr Tyr Ser Ile Ser Gly Tyr Gly Ala Ala Gly Gly Lys Gly 
            740                 745                 750         


Gly Lys Asn Thr Met Met Arg Ser His Gly Val Ser Val Leu Gly Ile 
        755                 760                 765             


Phe Asn Leu Glu Lys Asp Asp Met Leu Tyr Ile Leu Val Gly Gln Gln 
    770                 775                 780                 


Gly Glu Asp Ala Cys Pro Ser Thr Asn Gln Leu Ile Gln Lys Val Cys 
785                 790                 795                 800 


Ile Gly Glu Asn Asn Val Ile Glu Glu Glu Ile Arg Val Asn Arg Ser 
                805                 810                 815     


Val His Glu Trp Ala Gly Gly Gly Gly Gly Gly Gly Gly Ala Thr Tyr 
            820                 825                 830         


Val Phe Lys Met Lys Asp Gly Val Pro Val Pro Leu Ile Ile Ala Ala 
        835                 840                 845             


Gly Gly Gly Gly Arg Ala Tyr Gly Ala Lys Thr Asp Thr Phe His Pro 
    850                 855                 860                 


Glu Arg Leu Glu Asn Asn Ser Ser Val Leu Gly Leu Asn Gly Asn Ser 
865                 870                 875                 880 


Gly Ala Ala Gly Gly Gly Gly Gly Trp Asn Asp Asn Thr Ser Leu Leu 
                885                 890                 895     


Trp Ala Gly Lys Ser Leu Gln Glu Gly Ala Thr Gly Gly His Ser Cys 
            900                 905                 910         


Pro Gln Ala Met Lys Lys Trp Gly Trp Glu Thr Arg Gly Gly Phe Gly 
        915                 920                 925             


Gly Gly Gly Gly Gly Cys Ser Ser Gly Gly Gly Gly Gly Gly Tyr Ile 
    930                 935                 940                 


Gly Gly Asn Ala Ala Ser Asn Asn Asp Pro Glu Met Asp Gly Glu Asp 
945                 950                 955                 960 


Gly Val Ser Phe Ile Ser Pro Leu Gly Ile Leu Tyr Thr Pro Ala Leu 
                965                 970                 975     


Lys Val Met Glu Gly His Gly Glu Val Asn Ile Lys His Tyr Leu Asn 
            980                 985                 990         


Cys Ser His Cys Glu Val Asp Glu  Cys His Met Asp Pro  Glu Ser His 
        995                 1000                 1005             


Lys Val  Ile Cys Phe Cys Asp  His Gly Thr Val Leu  Ala Glu Asp 
    1010                 1015                 1020             


Gly Val  Ser Cys Ile Val Ser  Pro Thr Pro Glu Pro  His Leu Pro 
    1025                 1030                 1035             


Leu Ser  Leu Ile Leu Ser Val  Val Thr Ser Ala Leu  Val Ala Ala 
    1040                 1045                 1050             


Leu Val  Leu Ala Phe Ser Gly  Ile Met Ile Val Tyr  Arg Arg Lys 
    1055                 1060                 1065             


His Gln  Glu Leu Gln Ala Met  Gln Met Glu Leu Gln  Ser Pro Glu 
    1070                 1075                 1080             


Tyr Lys  Leu Ser Lys Leu Arg  Thr Ser Thr Ile Met  Thr Asp Tyr 
    1085                 1090                 1095             


Asn Pro  Asn Tyr Cys Phe Ala  Gly Lys Thr Ser Ser  Ile Ser Asp 
    1100                 1105                 1110             


Leu Lys  Glu Val Pro Arg Lys  Asn Ile Thr Leu Ile  Arg Gly Leu 
    1115                 1120                 1125             


Gly His  Gly Ala Phe Gly Glu  Val Tyr Glu Gly Gln  Val Ser Gly 
    1130                 1135                 1140             


Met Pro  Asn Asp Pro Ser Pro  Leu Gln Val Ala Val  Lys Thr Leu 
    1145                 1150                 1155             


Pro Glu  Val Cys Ser Glu Gln  Asp Glu Leu Asp Phe  Leu Met Glu 
    1160                 1165                 1170             


Ala Leu  Ile Ile Ser Lys Phe  Asn His Gln Asn Ile  Val Arg Cys 
    1175                 1180                 1185             


Ile Gly  Val Ser Leu Gln Ser  Leu Pro Arg Phe Ile  Leu Leu Glu 
    1190                 1195                 1200             


Leu Met  Ala Gly Gly Asp Leu  Lys Ser Phe Leu Arg  Glu Thr Arg 
    1205                 1210                 1215             


Pro Arg  Pro Ser Gln Pro Ser  Ser Leu Ala Met Leu  Asp Leu Leu 
    1220                 1225                 1230             


His Val  Ala Arg Asp Ile Ala  Cys Gly Cys Gln Tyr  Leu Glu Glu 
    1235                 1240                 1245             


Asn His  Phe Ile His Arg Asp  Ile Ala Ala Arg Asn  Cys Leu Leu 
    1250                 1255                 1260             


Thr Cys  Pro Gly Pro Gly Arg  Val Ala Lys Ile Gly  Asp Phe Gly 
    1265                 1270                 1275             


Met Ala  Arg Asp Ile Tyr Arg  Ala Ser Tyr Tyr Arg  Lys Gly Gly 
    1280                 1285                 1290             


Cys Ala  Met Leu Pro Val Lys  Trp Met Pro Pro Glu  Ala Phe Met 
    1295                 1300                 1305             


Glu Gly  Ile Phe Thr Ser Lys  Thr Asp Thr Trp Ser  Phe Gly Val 
    1310                 1315                 1320             


Leu Leu  Trp Glu Ile Phe Ser  Leu Gly Tyr Met Pro  Tyr Pro Ser 
    1325                 1330                 1335             


Lys Ser  Asn Gln Glu Val Leu  Glu Phe Val Thr Ser  Gly Gly Arg 
    1340                 1345                 1350             


Met Asp  Pro Pro Lys Asn Cys  Pro Gly Pro Val Tyr  Arg Ile Met 
    1355                 1360                 1365             


Thr Gln  Cys Trp Gln His Gln  Pro Glu Asp Arg Pro  Asn Phe Ala 
    1370                 1375                 1380             


Ile Ile  Leu Glu Arg Ile Glu  Tyr Cys Thr Gln Asp  Pro Asp Val 
    1385                 1390                 1395             


Ile Asn  Thr Ala Leu Pro Ile  Glu Tyr Gly Pro Leu  Val Glu Glu 
    1400                 1405                 1410             


Glu Glu  Lys Val Pro Val Arg  Pro Lys Asp Pro Glu  Gly Val Pro 
    1415                 1420                 1425             


Pro Leu  Leu Val Ser Gln Gln  Ala Lys Arg Glu Glu  Glu Arg Ser 
    1430                 1435                 1440             


Pro Ala  Ala Pro Pro Pro Leu  Pro Thr Thr Ser Ser  Gly Lys Ala 
    1445                 1450                 1455             


Ala Lys  Lys Pro Thr Ala Ala  Glu Ile Ser Val Arg  Val Pro Arg 
    1460                 1465                 1470             


Gly Pro  Ala Val Glu Gly Gly  His Val Asn Met Ala  Phe Ser Gln 
    1475                 1480                 1485             


Ser Asn  Pro Pro Ser Glu Leu  His Lys Val His Gly  Ser Arg Asn 
    1490                 1495                 1500             


Lys Pro  Thr Ser Leu Trp Asn  Pro Thr Tyr Gly Ser  Trp Phe Thr 
    1505                 1510                 1515             


Glu Lys  Pro Thr Lys Lys Asn  Asn Pro Ile Ala Lys  Lys Glu Pro 
    1520                 1525                 1530             


His Asp  Arg Gly Asn Leu Gly  Leu Glu Gly Ser Cys  Thr Val Pro 
    1535                 1540                 1545             


Pro Asn  Val Ala Thr Gly Arg  Leu Pro Gly Ala Ser  Leu Leu Leu 
    1550                 1555                 1560             


Glu Pro  Ser Ser Leu Thr Ala  Asn Met Lys Glu Val  Pro Leu Phe 
    1565                 1570                 1575             


Arg Leu  Arg His Phe Pro Cys  Gly Asn Val Asn Tyr  Gly Tyr Gln 
    1580                 1585                 1590             


Gln Gln  Gly Leu Pro Leu Glu  Ala Ala Thr Ala Pro  Gly Ala Gly 
    1595                 1600                 1605             


His Tyr  Glu Asp Thr Ile Leu  Lys Ser Lys Asn Ser  Met Asn Gln 
    1610                 1615                 1620             


Pro Gly  Pro 
    1625     


<210> 57
<211> 40
<212> PRT
<213> Homo sapiens

<400> 57
Ala Arg Ser His Thr His Phe Ser Ser Leu Gly Ser Leu Arg Pro Trp 
1               5                   10                  15      


Arg Arg Glu Arg Gln Trp Leu Leu His Lys Pro Glu Thr Lys Cys His 
            20                  25                  30          


Val Leu Phe Cys Ala Asn Leu Phe 
        35                  40  


<210> 58
<211> 8
<212> PRT
<213> Homo sapiens

<400> 58
Ser Thr Thr Lys Lys Ala Val Phe 
1               5               


<210> 59
<211> 24
<212> PRT
<213> Homo sapiens

<400> 59
Lys Cys Phe Arg Lys Val Leu Ser Met Gly Ser Ser Tyr Ser Phe Glu 
1               5                   10                  15      


Arg Arg Lys Tyr His Lys Asn Glu 
            20                  


<210> 60
<211> 8
<212> PRT
<213> Homo sapiens

<400> 60
Ile Gln Gly Pro Asp Val Val Ala 
1               5               


<210> 61
<211> 26
<212> PRT
<213> Homo sapiens

<400> 61
Gly Phe Tyr Ala Cys Leu Leu Tyr Thr Ser Leu Cys Phe Phe Gln Ile 
1               5                   10                  15      


Val Cys Ala Leu Leu Gln Cys Ser Gln Asn 
            20                  25      


<210> 62
<211> 16
<212> PRT
<213> Homo sapiens

<400> 62
Leu Leu Leu Cys Phe Ile Val Gly Val Ile Asp Val Ser Leu Pro Cys 
1               5                   10                  15      


<210> 63
<211> 20
<212> PRT
<213> Homo sapiens

<400> 63
Cys Gly His Glu Pro Phe Glu Gly Arg Gly Asn Gly Asn Lys Gly Val 
1               5                   10                  15      


Ile Cys Asn Asp 
            20  


<210> 64
<211> 1620
<212> PRT
<213> Homo sapiens

<400> 64
Met Gly Ala Ile Gly Leu Leu Trp Leu Leu Pro Leu Leu Leu Ser Thr 
1               5                   10                  15      


Ala Ala Val Gly Ser Gly Met Gly Thr Gly Gln Arg Ala Gly Ser Pro 
            20                  25                  30          


Ala Ala Gly Pro Pro Leu Gln Pro Arg Glu Pro Leu Ser Tyr Ser Arg 
        35                  40                  45              


Leu Gln Arg Lys Ser Leu Ala Val Asp Phe Val Val Pro Ser Leu Phe 
    50                  55                  60                  


Arg Val Tyr Ala Arg Asp Leu Leu Leu Pro Pro Ser Ser Ser Glu Leu 
65                  70                  75                  80  


Lys Ala Gly Arg Pro Glu Ala Arg Gly Ser Leu Ala Leu Asp Cys Ala 
                85                  90                  95      


Pro Leu Leu Arg Leu Leu Gly Pro Ala Pro Gly Val Ser Trp Thr Ala 
            100                 105                 110         


Gly Ser Pro Ala Pro Ala Glu Ala Arg Thr Leu Ser Arg Val Leu Lys 
        115                 120                 125             


Gly Gly Ser Val Arg Lys Leu Arg Arg Ala Lys Gln Leu Val Leu Glu 
    130                 135                 140                 


Leu Gly Glu Glu Ala Ile Leu Glu Gly Cys Val Gly Pro Pro Gly Glu 
145                 150                 155                 160 


Ala Ala Val Gly Leu Leu Gln Phe Asn Leu Ser Glu Leu Phe Ser Trp 
                165                 170                 175     


Trp Ile Arg Gln Gly Glu Gly Arg Leu Arg Ile Arg Leu Met Pro Glu 
            180                 185                 190         


Lys Lys Ala Ser Glu Val Gly Arg Glu Gly Arg Leu Ser Ala Ala Ile 
        195                 200                 205             


Arg Ala Ser Gln Pro Arg Leu Leu Phe Gln Ile Phe Gly Thr Gly His 
    210                 215                 220                 


Ser Ser Leu Glu Ser Pro Thr Asn Met Pro Ser Pro Ser Pro Asp Tyr 
225                 230                 235                 240 


Phe Thr Trp Asn Leu Thr Trp Ile Met Lys Asp Ser Phe Pro Phe Leu 
                245                 250                 255     


Ser His Arg Ser Arg Tyr Gly Leu Glu Cys Ser Phe Asp Phe Pro Cys 
            260                 265                 270         


Glu Leu Glu Tyr Ser Pro Pro Leu His Asp Leu Arg Asn Gln Ser Trp 
        275                 280                 285             


Ser Trp Arg Arg Ile Pro Ser Glu Glu Ala Ser Gln Met Asp Leu Leu 
    290                 295                 300                 


Asp Gly Pro Gly Ala Glu Arg Ser Lys Glu Met Pro Arg Gly Ser Phe 
305                 310                 315                 320 


Leu Leu Leu Asn Thr Ser Ala Asp Ser Lys His Thr Ile Leu Ser Pro 
                325                 330                 335     


Trp Met Arg Ser Ser Ser Glu His Cys Thr Leu Ala Val Ser Val His 
            340                 345                 350         


Arg His Leu Gln Pro Ser Gly Arg Tyr Ile Ala Gln Leu Leu Pro His 
        355                 360                 365             


Asn Glu Ala Ala Arg Glu Ile Leu Leu Met Pro Thr Pro Gly Lys His 
    370                 375                 380                 


Gly Trp Thr Val Leu Gln Gly Arg Ile Gly Arg Pro Asp Asn Pro Phe 
385                 390                 395                 400 


Arg Val Ala Leu Glu Tyr Ile Ser Ser Gly Asn Arg Ser Leu Ser Ala 
                405                 410                 415     


Val Asp Phe Phe Ala Leu Lys Asn Cys Ser Glu Gly Thr Ser Pro Gly 
            420                 425                 430         


Ser Lys Met Ala Leu Gln Ser Ser Phe Thr Cys Trp Asn Gly Thr Val 
        435                 440                 445             


Leu Gln Leu Gly Gln Ala Cys Asp Phe His Gln Asp Cys Ala Gln Gly 
    450                 455                 460                 


Glu Asp Glu Ser Gln Met Cys Arg Lys Leu Pro Val Gly Phe Tyr Cys 
465                 470                 475                 480 


Asn Phe Glu Asp Gly Phe Cys Gly Trp Thr Gln Gly Thr Leu Ser Pro 
                485                 490                 495     


His Thr Pro Gln Trp Gln Val Arg Thr Leu Lys Asp Ala Arg Phe Gln 
            500                 505                 510         


Asp His Gln Asp His Ala Leu Leu Leu Ser Thr Thr Asp Val Pro Ala 
        515                 520                 525             


Ser Glu Ser Ala Thr Val Thr Ser Ala Thr Phe Pro Ala Pro Ile Lys 
    530                 535                 540                 


Ser Ser Pro Cys Glu Leu Arg Met Ser Trp Leu Ile Arg Gly Val Leu 
545                 550                 555                 560 


Arg Gly Asn Val Ser Leu Val Leu Val Glu Asn Lys Thr Gly Lys Glu 
                565                 570                 575     


Gln Gly Arg Met Val Trp His Val Ala Ala Tyr Glu Gly Leu Ser Leu 
            580                 585                 590         


Trp Gln Trp Met Val Leu Pro Leu Leu Asp Val Ser Asp Arg Phe Trp 
        595                 600                 605             


Leu Gln Met Val Ala Trp Trp Gly Gln Gly Ser Arg Ala Ile Val Ala 
    610                 615                 620                 


Phe Asp Asn Ile Ser Ile Ser Leu Asp Cys Tyr Leu Thr Ile Ser Gly 
625                 630                 635                 640 


Glu Asp Lys Ile Leu Gln Asn Thr Ala Pro Lys Ser Arg Asn Leu Phe 
                645                 650                 655     


Glu Arg Asn Pro Asn Lys Glu Leu Lys Pro Gly Glu Asn Ser Pro Arg 
            660                 665                 670         


Gln Thr Pro Ile Phe Asp Pro Thr Val His Trp Leu Phe Thr Thr Cys 
        675                 680                 685             


Gly Ala Ser Gly Pro His Gly Pro Thr Gln Ala Gln Cys Asn Asn Ala 
    690                 695                 700                 


Tyr Gln Asn Ser Asn Leu Ser Val Glu Val Gly Ser Glu Gly Pro Leu 
705                 710                 715                 720 


Lys Gly Ile Gln Ile Trp Lys Val Pro Ala Thr Asp Thr Tyr Ser Ile 
                725                 730                 735     


Ser Gly Tyr Gly Ala Ala Gly Gly Lys Gly Gly Lys Asn Thr Met Met 
            740                 745                 750         


Arg Ser His Gly Val Ser Val Leu Gly Ile Phe Asn Leu Glu Lys Asp 
        755                 760                 765             


Asp Met Leu Tyr Ile Leu Val Gly Gln Gln Gly Glu Asp Ala Cys Pro 
    770                 775                 780                 


Ser Thr Asn Gln Leu Ile Gln Lys Val Cys Ile Gly Glu Asn Asn Val 
785                 790                 795                 800 


Ile Glu Glu Glu Ile Arg Val Asn Arg Ser Val His Glu Trp Ala Gly 
                805                 810                 815     


Gly Gly Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Lys Met Lys Asp 
            820                 825                 830         


Gly Val Pro Val Pro Leu Ile Ile Ala Ala Gly Gly Gly Gly Arg Ala 
        835                 840                 845             


Tyr Gly Ala Lys Thr Asp Thr Phe His Pro Glu Arg Leu Glu Asn Asn 
    850                 855                 860                 


Ser Ser Val Leu Gly Leu Asn Gly Asn Ser Gly Ala Ala Gly Gly Gly 
865                 870                 875                 880 


Gly Gly Trp Asn Asp Asn Thr Ser Leu Leu Trp Ala Gly Lys Ser Leu 
                885                 890                 895     


Gln Glu Gly Ala Thr Gly Gly His Ser Cys Pro Gln Ala Met Lys Lys 
            900                 905                 910         


Trp Gly Trp Glu Thr Arg Gly Gly Phe Gly Gly Gly Gly Gly Gly Cys 
        915                 920                 925             


Ser Ser Gly Gly Gly Gly Gly Gly Tyr Ile Gly Gly Asn Ala Ala Ser 
    930                 935                 940                 


Asn Asn Asp Pro Glu Met Asp Gly Glu Asp Gly Val Ser Phe Ile Ser 
945                 950                 955                 960 


Pro Leu Gly Ile Leu Tyr Thr Pro Ala Leu Lys Val Met Glu Gly His 
                965                 970                 975     


Gly Glu Val Asn Ile Lys His Tyr Leu Asn Cys Ser His Cys Glu Val 
            980                 985                 990         


Asp Glu Cys His Met Asp Pro Glu  Ser His Lys Val Ile  Cys Phe Cys 
        995                 1000                 1005             


Asp His  Gly Thr Val Leu Ala  Glu Asp Gly Val Ser  Cys Ile Val 
    1010                 1015                 1020             


Ser Pro  Thr Pro Glu Pro His  Leu Pro Leu Ser Leu  Ile Leu Ser 
    1025                 1030                 1035             


Val Val  Thr Ser Ala Leu Val  Ala Ala Leu Val Leu  Ala Phe Ser 
    1040                 1045                 1050             


Gly Ile  Met Ile Val Tyr Arg  Arg Lys His Gln Glu  Leu Gln Ala 
    1055                 1060                 1065             


Met Gln  Met Glu Leu Gln Ser  Pro Glu Tyr Lys Leu  Ser Lys Leu 
    1070                 1075                 1080             


Arg Thr  Ser Thr Ile Met Thr  Asp Tyr Asn Pro Asn  Tyr Cys Phe 
    1085                 1090                 1095             


Ala Gly  Lys Thr Ser Ser Ile  Ser Asp Leu Lys Glu  Val Pro Arg 
    1100                 1105                 1110             


Lys Asn  Ile Thr Leu Ile Arg  Gly Leu Gly His Gly  Ala Phe Gly 
    1115                 1120                 1125             


Glu Val  Tyr Glu Gly Gln Val  Ser Gly Met Pro Asn  Asp Pro Ser 
    1130                 1135                 1140             


Pro Leu  Gln Val Ala Val Lys  Thr Leu Pro Glu Val  Cys Ser Glu 
    1145                 1150                 1155             


Gln Asp  Glu Leu Asp Phe Leu  Met Glu Ala Leu Ile  Ile Ser Lys 
    1160                 1165                 1170             


Phe Asn  His Gln Asn Ile Val  Arg Cys Ile Gly Val  Ser Leu Gln 
    1175                 1180                 1185             


Ser Leu  Pro Arg Phe Ile Leu  Leu Glu Leu Met Ala  Gly Gly Asp 
    1190                 1195                 1200             


Leu Lys  Ser Phe Leu Arg Glu  Thr Arg Pro Arg Pro  Ser Gln Pro 
    1205                 1210                 1215             


Ser Ser  Leu Ala Met Leu Asp  Leu Leu His Val Ala  Arg Asp Ile 
    1220                 1225                 1230             


Ala Cys  Gly Cys Gln Tyr Leu  Glu Glu Asn His Phe  Ile His Arg 
    1235                 1240                 1245             


Asp Ile  Ala Ala Arg Asn Cys  Leu Leu Thr Cys Pro  Gly Pro Gly 
    1250                 1255                 1260             


Arg Val  Ala Lys Ile Gly Asp  Phe Gly Met Ala Arg  Asp Ile Tyr 
    1265                 1270                 1275             


Arg Ala  Ser Tyr Tyr Arg Lys  Gly Gly Cys Ala Met  Leu Pro Val 
    1280                 1285                 1290             


Lys Trp  Met Pro Pro Glu Ala  Phe Met Glu Gly Ile  Phe Thr Ser 
    1295                 1300                 1305             


Lys Thr  Asp Thr Trp Ser Phe  Gly Val Leu Leu Trp  Glu Ile Phe 
    1310                 1315                 1320             


Ser Leu  Gly Tyr Met Pro Tyr  Pro Ser Lys Ser Asn  Gln Glu Val 
    1325                 1330                 1335             


Leu Glu  Phe Val Thr Ser Gly  Gly Arg Met Asp Pro  Pro Lys Asn 
    1340                 1345                 1350             


Cys Pro  Gly Pro Val Tyr Arg  Ile Met Thr Gln Cys  Trp Gln His 
    1355                 1360                 1365             


Gln Pro  Glu Asp Arg Pro Asn  Phe Ala Ile Ile Leu  Glu Arg Ile 
    1370                 1375                 1380             


Glu Tyr  Cys Thr Gln Asp Pro  Asp Val Ile Asn Thr  Ala Leu Pro 
    1385                 1390                 1395             


Ile Glu  Tyr Gly Pro Leu Val  Glu Glu Glu Glu Lys  Val Pro Val 
    1400                 1405                 1410             


Arg Pro  Lys Asp Pro Glu Gly  Val Pro Pro Leu Leu  Val Ser Gln 
    1415                 1420                 1425             


Gln Ala  Lys Arg Glu Glu Glu  Arg Ser Pro Ala Ala  Pro Pro Pro 
    1430                 1435                 1440             


Leu Pro  Thr Thr Ser Ser Gly  Lys Ala Ala Lys Lys  Pro Thr Ala 
    1445                 1450                 1455             


Ala Glu  Ile Ser Val Arg Val  Pro Arg Gly Pro Ala  Val Glu Gly 
    1460                 1465                 1470             


Gly His  Val Asn Met Ala Phe  Ser Gln Ser Asn Pro  Pro Ser Glu 
    1475                 1480                 1485             


Leu His  Lys Val His Gly Ser  Arg Asn Lys Pro Thr  Ser Leu Trp 
    1490                 1495                 1500             


Asn Pro  Thr Tyr Gly Ser Trp  Phe Thr Glu Lys Pro  Thr Lys Lys 
    1505                 1510                 1515             


Asn Asn  Pro Ile Ala Lys Lys  Glu Pro His Asp Arg  Gly Asn Leu 
    1520                 1525                 1530             


Gly Leu  Glu Gly Ser Cys Thr  Val Pro Pro Asn Val  Ala Thr Gly 
    1535                 1540                 1545             


Arg Leu  Pro Gly Ala Ser Leu  Leu Leu Glu Pro Ser  Ser Leu Thr 
    1550                 1555                 1560             


Ala Asn  Met Lys Glu Val Pro  Leu Phe Arg Leu Arg  His Phe Pro 
    1565                 1570                 1575             


Cys Gly  Asn Val Asn Tyr Gly  Tyr Gln Gln Gln Gly  Leu Pro Leu 
    1580                 1585                 1590             


Glu Ala  Ala Thr Ala Pro Gly  Ala Gly His Tyr Glu  Asp Thr Ile 
    1595                 1600                 1605             


Leu Lys  Ser Lys Asn Ser Met  Asn Gln Pro Gly Pro  
    1610                 1615                 1620 


<210> 65
<211> 1620
<212> PRT
<213> Homo sapiens

<400> 65
Met Gly Ala Ile Gly Leu Leu Trp Leu Leu Pro Leu Leu Leu Ser Thr 
1               5                   10                  15      


Ala Ala Val Gly Ser Gly Met Gly Thr Gly Gln Arg Ala Gly Ser Pro 
            20                  25                  30          


Ala Ala Gly Pro Pro Leu Gln Pro Arg Glu Pro Leu Ser Tyr Ser Arg 
        35                  40                  45              


Leu Gln Arg Lys Ser Leu Ala Val Asp Phe Val Val Pro Ser Leu Phe 
    50                  55                  60                  


Arg Val Tyr Ala Arg Asp Leu Leu Leu Pro Pro Ser Ser Ser Glu Leu 
65                  70                  75                  80  


Lys Ala Gly Arg Pro Glu Ala Arg Gly Ser Leu Ala Leu Asp Cys Ala 
                85                  90                  95      


Pro Leu Leu Arg Leu Leu Gly Pro Ala Pro Gly Val Ser Trp Thr Ala 
            100                 105                 110         


Gly Ser Pro Ala Pro Ala Glu Ala Arg Thr Leu Ser Arg Val Leu Lys 
        115                 120                 125             


Gly Gly Ser Val Arg Lys Leu Arg Arg Ala Lys Gln Leu Val Leu Glu 
    130                 135                 140                 


Leu Gly Glu Glu Ala Ile Leu Glu Gly Cys Val Gly Pro Pro Gly Glu 
145                 150                 155                 160 


Ala Ala Val Gly Leu Leu Gln Phe Asn Leu Ser Glu Leu Phe Ser Trp 
                165                 170                 175     


Trp Ile Arg Gln Gly Glu Gly Arg Leu Arg Ile Arg Leu Met Pro Glu 
            180                 185                 190         


Lys Lys Ala Ser Glu Val Gly Arg Glu Gly Arg Leu Ser Ala Ala Ile 
        195                 200                 205             


Arg Ala Ser Gln Pro Arg Leu Leu Phe Gln Ile Phe Gly Thr Gly His 
    210                 215                 220                 


Ser Ser Leu Glu Ser Pro Thr Asn Met Pro Ser Pro Ser Pro Asp Tyr 
225                 230                 235                 240 


Phe Thr Trp Asn Leu Thr Trp Ile Met Lys Asp Ser Phe Pro Phe Leu 
                245                 250                 255     


Ser His Arg Ser Arg Tyr Gly Leu Glu Cys Ser Phe Asp Phe Pro Cys 
            260                 265                 270         


Glu Leu Glu Tyr Ser Pro Pro Leu His Asp Leu Arg Asn Gln Ser Trp 
        275                 280                 285             


Ser Trp Arg Arg Ile Pro Ser Glu Glu Ala Ser Gln Met Asp Leu Leu 
    290                 295                 300                 


Asp Gly Pro Gly Ala Glu Arg Ser Lys Glu Met Pro Arg Gly Ser Phe 
305                 310                 315                 320 


Leu Leu Leu Asn Thr Ser Ala Asp Ser Lys His Thr Ile Leu Ser Pro 
                325                 330                 335     


Trp Met Arg Ser Ser Ser Glu His Cys Thr Leu Ala Val Ser Val His 
            340                 345                 350         


Arg His Leu Gln Pro Ser Gly Arg Tyr Ile Ala Gln Leu Leu Pro His 
        355                 360                 365             


Asn Glu Ala Ala Arg Glu Ile Leu Leu Met Pro Thr Pro Gly Lys His 
    370                 375                 380                 


Gly Trp Thr Val Leu Gln Gly Arg Ile Gly Arg Pro Asp Asn Pro Phe 
385                 390                 395                 400 


Arg Val Ala Leu Glu Tyr Ile Ser Ser Gly Asn Arg Ser Leu Ser Ala 
                405                 410                 415     


Val Asp Phe Phe Ala Leu Lys Asn Cys Ser Glu Gly Thr Ser Pro Gly 
            420                 425                 430         


Ser Lys Met Ala Leu Gln Ser Ser Phe Thr Cys Trp Asn Gly Thr Val 
        435                 440                 445             


Leu Gln Leu Gly Gln Ala Cys Asp Phe His Gln Asp Cys Ala Gln Gly 
    450                 455                 460                 


Glu Asp Glu Ser Gln Met Cys Arg Lys Leu Pro Val Gly Phe Tyr Cys 
465                 470                 475                 480 


Asn Phe Glu Asp Gly Phe Cys Gly Trp Thr Gln Gly Thr Leu Ser Pro 
                485                 490                 495     


His Thr Pro Gln Trp Gln Val Arg Thr Leu Lys Asp Ala Arg Phe Gln 
            500                 505                 510         


Asp His Gln Asp His Ala Leu Leu Leu Ser Thr Thr Asp Val Pro Ala 
        515                 520                 525             


Ser Glu Ser Ala Thr Val Thr Ser Ala Thr Phe Pro Ala Pro Ile Lys 
    530                 535                 540                 


Ser Ser Pro Cys Glu Leu Arg Met Ser Trp Leu Ile Arg Gly Val Leu 
545                 550                 555                 560 


Arg Gly Asn Val Ser Leu Val Leu Val Glu Asn Lys Thr Gly Lys Glu 
                565                 570                 575     


Gln Gly Arg Met Val Trp His Val Ala Ala Tyr Glu Gly Leu Ser Leu 
            580                 585                 590         


Trp Gln Trp Met Val Leu Pro Leu Leu Asp Val Ser Asp Arg Phe Trp 
        595                 600                 605             


Leu Gln Met Val Ala Trp Trp Gly Gln Gly Ser Arg Ala Ile Val Ala 
    610                 615                 620                 


Phe Asp Asn Ile Ser Ile Ser Leu Asp Cys Tyr Leu Thr Ile Ser Gly 
625                 630                 635                 640 


Glu Asp Lys Ile Leu Gln Asn Thr Ala Pro Lys Ser Arg Asn Leu Phe 
                645                 650                 655     


Glu Arg Asn Pro Asn Lys Glu Leu Lys Pro Gly Glu Asn Ser Pro Arg 
            660                 665                 670         


Gln Thr Pro Ile Phe Asp Pro Thr Val His Trp Leu Phe Thr Thr Cys 
        675                 680                 685             


Gly Ala Ser Gly Pro His Gly Pro Thr Gln Ala Gln Cys Asn Asn Ala 
    690                 695                 700                 


Tyr Gln Asn Ser Asn Leu Ser Val Glu Val Gly Ser Glu Gly Pro Leu 
705                 710                 715                 720 


Lys Gly Ile Gln Ile Trp Lys Val Pro Ala Thr Asp Thr Tyr Ser Ile 
                725                 730                 735     


Ser Gly Tyr Gly Ala Ala Gly Gly Lys Gly Gly Lys Asn Thr Met Met 
            740                 745                 750         


Arg Ser His Gly Val Ser Val Leu Gly Ile Phe Asn Leu Glu Lys Asp 
        755                 760                 765             


Asp Met Leu Tyr Ile Leu Val Gly Gln Gln Gly Glu Asp Ala Cys Pro 
    770                 775                 780                 


Ser Thr Asn Gln Leu Ile Gln Lys Val Cys Ile Gly Glu Asn Asn Val 
785                 790                 795                 800 


Ile Glu Glu Glu Ile Arg Val Asn Arg Ser Val His Glu Trp Ala Gly 
                805                 810                 815     


Gly Gly Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Lys Met Lys Asp 
            820                 825                 830         


Gly Val Pro Val Pro Leu Ile Ile Ala Ala Gly Gly Gly Gly Arg Ala 
        835                 840                 845             


Tyr Gly Ala Lys Thr Asp Thr Phe His Pro Glu Arg Leu Glu Asn Asn 
    850                 855                 860                 


Ser Ser Val Leu Gly Leu Asn Gly Asn Ser Gly Ala Ala Gly Gly Gly 
865                 870                 875                 880 


Gly Gly Trp Asn Asp Asn Thr Ser Leu Leu Trp Ala Gly Lys Ser Leu 
                885                 890                 895     


Gln Glu Gly Ala Thr Gly Gly His Ser Cys Pro Gln Ala Met Lys Lys 
            900                 905                 910         


Trp Gly Trp Glu Thr Arg Gly Gly Phe Gly Gly Gly Gly Gly Gly Cys 
        915                 920                 925             


Ser Ser Gly Gly Gly Gly Gly Gly Tyr Ile Gly Gly Asn Ala Ala Ser 
    930                 935                 940                 


Asn Asn Asp Pro Glu Met Asp Gly Glu Asp Gly Val Ser Phe Ile Ser 
945                 950                 955                 960 


Pro Leu Gly Ile Leu Tyr Thr Pro Ala Leu Lys Val Met Glu Gly His 
                965                 970                 975     


Gly Glu Val Asn Ile Lys His Tyr Leu Asn Cys Ser His Cys Glu Val 
            980                 985                 990         


Asp Glu Cys His Met Asp Pro Glu  Ser His Lys Val Ile  Cys Phe Cys 
        995                 1000                 1005             


Asp His  Gly Thr Val Leu Ala  Glu Asp Gly Val Ser  Cys Ile Val 
    1010                 1015                 1020             


Ser Pro  Thr Pro Glu Pro His  Leu Pro Leu Ser Leu  Ile Leu Ser 
    1025                 1030                 1035             


Val Val  Thr Ser Ala Leu Val  Ala Ala Leu Val Leu  Ala Phe Ser 
    1040                 1045                 1050             


Gly Ile  Met Ile Val Tyr Arg  Arg Lys His Gln Glu  Leu Gln Ala 
    1055                 1060                 1065             


Met Gln  Met Glu Leu Gln Ser  Pro Glu Tyr Lys Leu  Ser Lys Leu 
    1070                 1075                 1080             


Arg Thr  Ser Thr Ile Met Thr  Asp Tyr Asn Pro Asn  Tyr Cys Phe 
    1085                 1090                 1095             


Ala Gly  Lys Thr Ser Ser Ile  Ser Asp Leu Lys Glu  Val Pro Arg 
    1100                 1105                 1110             


Lys Asn  Ile Thr Leu Ile Arg  Gly Leu Gly His Gly  Ala Phe Gly 
    1115                 1120                 1125             


Glu Val  Tyr Glu Gly Gln Val  Ser Gly Met Pro Asn  Asp Pro Ser 
    1130                 1135                 1140             


Pro Leu  Gln Val Ala Val Lys  Thr Leu Pro Glu Val  Cys Ser Glu 
    1145                 1150                 1155             


Gln Asp  Glu Leu Asp Phe Leu  Met Glu Ala Leu Ile  Ile Ser Lys 
    1160                 1165                 1170             


Phe Asn  His Gln Asn Ile Val  Arg Cys Ile Gly Val  Ser Leu Gln 
    1175                 1180                 1185             


Ser Leu  Pro Arg Phe Ile Leu  Leu Glu Leu Met Ala  Gly Gly Asp 
    1190                 1195                 1200             


Leu Lys  Ser Phe Leu Arg Glu  Thr Arg Pro Arg Pro  Ser Gln Pro 
    1205                 1210                 1215             


Ser Ser  Leu Ala Met Leu Asp  Leu Leu His Val Ala  Arg Asp Ile 
    1220                 1225                 1230             


Ala Cys  Gly Cys Gln Tyr Leu  Glu Glu Asn His Phe  Ile His Arg 
    1235                 1240                 1245             


Asp Ile  Ala Ala Arg Asn Cys  Leu Leu Thr Cys Pro  Gly Pro Gly 
    1250                 1255                 1260             


Arg Val  Ala Lys Ile Gly Asp  Phe Gly Met Ala Arg  Asp Ile Tyr 
    1265                 1270                 1275             


Arg Ala  Ser Tyr Tyr Arg Lys  Gly Gly Cys Ala Met  Leu Pro Val 
    1280                 1285                 1290             


Lys Trp  Met Pro Pro Glu Ala  Phe Met Glu Gly Ile  Phe Thr Ser 
    1295                 1300                 1305             


Lys Thr  Asp Thr Trp Ser Phe  Gly Val Leu Leu Trp  Glu Ile Phe 
    1310                 1315                 1320             


Ser Leu  Gly Tyr Met Pro Tyr  Pro Ser Lys Ser Asn  Gln Glu Val 
    1325                 1330                 1335             


Leu Glu  Phe Val Thr Ser Gly  Gly Arg Met Asp Pro  Pro Lys Asn 
    1340                 1345                 1350             


Cys Pro  Gly Pro Val Tyr Arg  Ile Met Thr Gln Cys  Trp Gln His 
    1355                 1360                 1365             


Gln Pro  Glu Asp Arg Pro Asn  Phe Ala Ile Ile Leu  Glu Arg Ile 
    1370                 1375                 1380             


Glu Tyr  Cys Thr Gln Asp Pro  Asp Val Ile Asn Thr  Ala Leu Pro 
    1385                 1390                 1395             


Ile Glu  Tyr Gly Pro Leu Val  Glu Glu Glu Glu Lys  Val Pro Val 
    1400                 1405                 1410             


Arg Pro  Lys Asp Pro Glu Gly  Val Pro Pro Leu Leu  Val Ser Gln 
    1415                 1420                 1425             


Gln Ala  Lys Arg Glu Glu Glu  Arg Ser Pro Ala Ala  Pro Pro Pro 
    1430                 1435                 1440             


Leu Pro  Thr Thr Ser Ser Gly  Lys Ala Ala Lys Lys  Pro Thr Ala 
    1445                 1450                 1455             


Ala Glu  Ile Ser Val Arg Val  Pro Arg Gly Pro Ala  Val Glu Gly 
    1460                 1465                 1470             


Gly His  Val Asn Met Ala Phe  Ser Gln Ser Asn Pro  Pro Ser Glu 
    1475                 1480                 1485             


Leu His  Lys Val His Gly Ser  Arg Asn Lys Pro Thr  Ser Leu Trp 
    1490                 1495                 1500             


Asn Pro  Thr Tyr Gly Ser Trp  Phe Thr Glu Lys Pro  Thr Lys Lys 
    1505                 1510                 1515             


Asn Asn  Pro Ile Ala Lys Lys  Glu Pro His Asp Arg  Gly Asn Leu 
    1520                 1525                 1530             


Gly Leu  Glu Gly Ser Cys Thr  Val Pro Pro Asn Val  Ala Thr Gly 
    1535                 1540                 1545             


Arg Leu  Pro Gly Ala Ser Leu  Leu Leu Glu Pro Ser  Ser Leu Thr 
    1550                 1555                 1560             


Ala Asn  Met Lys Glu Val Pro  Leu Phe Arg Leu Arg  His Phe Pro 
    1565                 1570                 1575             


Cys Gly  Asn Val Asn Tyr Gly  Tyr Gln Gln Gln Gly  Leu Pro Leu 
    1580                 1585                 1590             


Glu Ala  Ala Thr Ala Pro Gly  Ala Gly His Tyr Glu  Asp Thr Ile 
    1595                 1600                 1605             


Leu Lys  Ser Lys Asn Ser Met  Asn Gln Pro Gly Pro  
    1610                 1615                 1620 


<210> 66
<211> 634
<212> PRT
<213> Mus musculus

<400> 66
Met Gly Gln Arg Gln Ser Ile Leu Lys Arg Cys Pro Glu Gly Ser Phe 
1               5                   10                  15      


Leu Leu Leu Asn Thr Ser Ala Asp Ser Lys His Thr Ile Leu Ser Pro 
            20                  25                  30          


Trp Met Arg Ser Ser Ser Asp His Cys Thr Leu Ala Val Ser Val His 
        35                  40                  45              


Arg His Leu Gln Pro Ser Gly Arg Tyr Val Ala Gln Leu Leu Pro His 
    50                  55                  60                  


Asn Glu Ala Gly Arg Glu Ile Leu Leu Val Pro Thr Pro Gly Lys His 
65                  70                  75                  80  


Gly Trp Thr Val Leu Gln Gly Arg Val Gly Arg Pro Ala Asn Pro Phe 
                85                  90                  95      


Arg Val Ala Leu Glu Tyr Ile Ser Ser Gly Asn Arg Ser Leu Ser Ala 
            100                 105                 110         


Val Asp Phe Phe Ala Leu Lys Asn Cys Ser Glu Gly Thr Ser Pro Gly 
        115                 120                 125             


Ser Lys Met Ala Leu Gln Ser Ser Phe Thr Cys Trp Asn Gly Thr Val 
    130                 135                 140                 


Leu Gln Leu Gly Gln Ala Cys Asp Phe His Gln Asp Cys Ala Gln Gly 
145                 150                 155                 160 


Glu Asp Glu Gly Gln Leu Cys Ser Lys Leu Pro Ala Gly Phe Tyr Cys 
                165                 170                 175     


Asn Phe Glu Asn Gly Phe Cys Gly Trp Thr Gln Ser Pro Leu Ser Pro 
            180                 185                 190         


His Met Pro Arg Trp Gln Val Arg Thr Leu Arg Asp Ala His Ser Gln 
        195                 200                 205             


Gly His Gln Gly Arg Ala Leu Leu Leu Ser Thr Thr Asp Ile Leu Ala 
    210                 215                 220                 


Ser Glu Gly Ala Thr Val Thr Ser Ala Thr Phe Pro Ala Pro Met Lys 
225                 230                 235                 240 


Asn Ser Pro Cys Glu Leu Arg Met Ser Trp Leu Ile Arg Gly Val Leu 
                245                 250                 255     


Arg Gly Asn Val Ser Leu Val Leu Val Glu Asn Lys Thr Gly Lys Glu 
            260                 265                 270         


Gln Ser Arg Thr Val Trp His Val Ala Thr Asp Glu Gly Leu Ser Leu 
        275                 280                 285             


Trp Gln His Thr Val Leu Ser Leu Leu Asp Val Thr Asp Arg Phe Trp 
    290                 295                 300                 


Leu Gln Ile Val Thr Trp Trp Gly Pro Gly Ser Arg Ala Thr Val Gly 
305                 310                 315                 320 


Phe Asp Asn Ile Ser Ile Ser Leu Asp Cys Tyr Leu Thr Ile Ser Gly 
                325                 330                 335     


Glu Glu Lys Met Ser Leu Asn Ser Val Pro Lys Ser Arg Asn Leu Phe 
            340                 345                 350         


Glu Lys Asn Pro Asn Lys Glu Ser Lys Ser Trp Ala Asn Ile Ser Gly 
        355                 360                 365             


Pro Thr Pro Ile Phe Asp Pro Thr Val His Trp Leu Phe Thr Thr Cys 
    370                 375                 380                 


Gly Ala Ser Gly Pro His Gly Pro Thr Gln Ala Gln Cys Asn Asn Ala 
385                 390                 395                 400 


Tyr Gln Asn Ser Asn Leu Ser Val Val Val Gly Ser Glu Gly Pro Leu 
                405                 410                 415     


Lys Gly Val Gln Ile Trp Lys Val Pro Ala Thr Asp Thr Tyr Ser Ile 
            420                 425                 430         


Ser Gly Tyr Gly Ala Ala Gly Gly Lys Gly Gly Lys Asn Thr Met Met 
        435                 440                 445             


Arg Ser His Gly Val Ser Val Leu Gly Ile Phe Asn Leu Glu Lys Gly 
    450                 455                 460                 


Asp Thr Leu Tyr Ile Leu Val Gly Gln Gln Gly Glu Asp Ala Cys Pro 
465                 470                 475                 480 


Arg Ala Asn Gln Leu Ile Gln Lys Val Cys Val Gly Glu Asn Asn Val 
                485                 490                 495     


Ile Glu Glu Glu Ile Arg Val Asn Arg Ser Val His Glu Trp Ala Gly 
            500                 505                 510         


Gly Gly Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Lys Met Lys Asp 
        515                 520                 525             


Gly Val Pro Val Pro Leu Ile Ile Ala Ala Gly Gly Gly Gly Arg Ala 
    530                 535                 540                 


Tyr Gly Ala Lys Thr Glu Thr Phe His Pro Glu Arg Leu Glu Ser Asn 
545                 550                 555                 560 


Ser Ser Val Leu Gly Leu Asn Gly Asn Ser Gly Ala Ala Gly Gly Gly 
                565                 570                 575     


Gly Gly Trp Asn Asp Asn Thr Ser Leu Leu Trp Ala Gly Lys Ser Leu 
            580                 585                 590         


Leu Glu Gly Ala Ala Gly Gly His Ser Cys Pro Gln Ala Met Lys Lys 
        595                 600                 605             


Trp Gly Trp Glu Thr Arg Gly Gly Phe Gly Gly Gly Gly Gly Gly Gly 
    610                 615                 620                 


Ala Pro Gln Val Glu Glu Ala Glu Asp Ile 
625                 630                 


<210> 67
<211> 6240
<212> DNA
<213> Homo sapiens

<400> 67
agatgcgatc cagcggctct gggggcggca gcggtggtag cagctggtac ctcccgccgc       60

ctctgttcgg agggtcgcgg ggcaccgagg tgctttccgg ccgccctctg gtcggccacc      120

caaagccgcg ggcgctgatg atgggtgagg agggggcggc aagatttcgg gcgcccctgc      180

cctgaacgcc ctcagctgct gccgccgggg ccgctccagt gcctgcgaac tctgaggagc      240

cgaggcgccg gtgagagcaa ggacgctgca aacttgcgca gcgcgggggc tgggattcac      300

gcccagaagt tcagcaggca gacagtccga agccttcccg cagcggagag atagcttgag      360

ggtgcgcaag acggcagcct ccgccctcgg ttcccgccca gaccgggcag aagagcttgg      420

aggagccaaa aggaacgcaa aaggcggcca ggacagcgtg cagcagctgg gagccgccgt      480

tctcagcctt aaaagttgca gagattggag gctgccccga gaggggacag accccagctc      540

cgactgcggg gggcaggaga ggacggtacc caactgccac ctcccttcaa ccatagtagt      600

tcctctgtac cgagcgcagc gagctacaga cgggggcgcg gcactcggcg cggagagcgg      660

gaggctcaag gtcccagcca gtgagcccag tgtgcttgag tgtctctgga ctcgcccctg      720

agcttccagg tctgtttcat ttagactcct gctcgcctcc gtgcagttgg gggaaagcaa      780

gagacttgcg cgcacgcaca gtcctctgga gatcaggtgg aaggagccgc tgggtaccaa      840

ggactgttca gagcctcttc ccatctcggg gagagcgaag ggtgaggctg ggcccggaga      900

gcagtgtaaa cggcctcctc cggcgggatg ggagccatcg ggctcctgtg gctcctgccg      960

ctgctgcttt ccacggcagc tgtgggctcc gggatgggga ccggccagcg cgcgggctcc     1020

ccagctgcgg ggccgccgct gcagccccgg gagccactca gctactcgcg cctgcagagg     1080

aagagtctgg cagttgactt cgtggtgccc tcgctcttcc gtgtctacgc ccgggaccta     1140

ctgctgccac catcctcctc ggagctgaag gctggcaggc ccgaggcccg cggctcgcta     1200

gctctggact gcgccccgct gctcaggttg ctggggccgg cgccgggggt ctcctggacc     1260

gccggttcac cagccccggc agaggcccgg acgctgtcca gggtgctgaa gggcggctcc     1320

gtgcgcaagc tccggcgtgc caagcagttg gtgctggagc tgggcgagga ggcgatcttg     1380

gagggttgcg tcgggccccc cggggaggcg gctgtggggc tgctccagtt caatctcagc     1440

gagctgttca gttggtggat tcgccaaggc gaagggcgac tgaggatccg cctgatgccc     1500

gagaagaagg cgtcggaagt gggcagagag ggaaggctgt ccgcggcaat tcgcgcctcc     1560

cagccccgcc ttctcttcca gatcttcggg actggtcata gctccttgga atcaccaaca     1620

aacatgcctt ctccttctcc tgattatttt acatggaatc tcacctggat aatgaaagac     1680

tccttccctt tcctgtctca tcgcagccga tatggtctgg agtgcagctt tgacttcccc     1740

tgtgagctgg agtattcccc tccactgcat gacctcagga accagagctg gtcctggcgc     1800

cgcatcccct ccgaggaggc ctcccagatg gacttgctgg atgggcctgg ggcagagcgt     1860

tctaaggaga tgcccagagg ctcctttctc cttctcaaca cctcagctga ctccaagcac     1920

accatcctga gtccgtggat gaggagcagc agtgagcact gcacactggc cgtctcggtg     1980

cacaggcacc tgcagccctc tggaaggtac attgcccagc tgctgcccca caacgaggct     2040

gcaagagaga tcctcctgat gcccactcca gggaagcatg gttggacagt gctccaggga     2100

agaatcgggc gtccagacaa cccatttcga gtggccctgg aatacatctc cagtggaaac     2160

cgcagcttgt ctgcagtgga cttctttgcc ctgaagaact gcagtgaagg aacatcccca     2220

ggctccaaga tggccctgca gagctccttc acttgttgga atgggacagt cctccagctt     2280

gggcaggcct gtgacttcca ccaggactgt gcccagggag aagatgagag ccagatgtgc     2340

cggaaactgc ctgtgggttt ttactgcaac tttgaagatg gcttctgtgg ctggacccaa     2400

ggcacactgt caccccacac tcctcaatgg caggtcagga ccctaaagga tgcccggttc     2460

caggaccacc aagaccatgc tctattgctc agtaccactg atgtccccgc ttctgaaagt     2520

gctacagtga ccagtgctac gtttcctgca ccgatcaaga gctctccatg tgagctccga     2580

atgtcctggc tcattcgtgg agtcttgagg ggaaacgtgt ccttggtgct agtggagaac     2640

aaaaccggga aggagcaagg caggatggtc tggcatgtcg ccgcctatga aggcttgagc     2700

ctgtggcagt ggatggtgtt gcctctcctc gatgtgtctg acaggttctg gctgcagatg     2760

gtcgcatggt ggggacaagg atccagagcc atcgtggctt ttgacaatat ctccatcagc     2820

ctggactgct acctcaccat tagcggagag gacaagatcc tgcagaatac agcacccaaa     2880

tcaagaaacc tgtttgagag aaacccaaac aaggagctga aacccgggga aaattcacca     2940

agacagaccc ccatctttga ccctacagtt cattggctgt tcaccacatg tggggccagc     3000

gggccccatg gccccaccca ggcacagtgc aacaacgcct accagaactc caacctgagc     3060

gtggaggtgg ggagcgaggg ccccctgaaa ggcatccaga tctggaaggt gccagccacc     3120

gacacctaca gcatctcggg ctacggagct gctggcggga aaggcgggaa gaacaccatg     3180

atgcggtccc acggcgtgtc tgtgctgggc atcttcaacc tggagaagga tgacatgctg     3240

tacatcctgg ttgggcagca gggagaggac gcctgcccca gtacaaacca gttaatccag     3300

aaagtctgca ttggagagaa caatgtgata gaagaagaaa tccgtgtgaa cagaagcgtg     3360

catgagtggg caggaggcgg aggaggaggg ggtggagcca cctacgtatt taagatgaag     3420

gatggagtgc cggtgcccct gatcattgca gccggaggtg gtggcagggc ctacggggcc     3480

aagacagaca cgttccaccc agagagactg gagaataact cctcggttct agggctaaac     3540

ggcaattccg gagccgcagg tggtggaggt ggctggaatg ataacacttc cttgctctgg     3600

gccggaaaat ctttgcagga gggtgccacc ggaggacatt cctgccccca ggccatgaag     3660

aagtgggggt gggagacaag agggggtttc ggagggggtg gaggggggtg ctcctcaggt     3720

ggaggaggcg gaggatatat aggcggcaat gcagcctcaa acaatgaccc cgaaatggat     3780

ggggaagatg gggtttcctt catcagtcca ctgggcatcc tgtacacccc agctttaaaa     3840

gtgatggaag gccacgggga agtgaatatt aagcattatc taaactgcag tcactgtgag     3900

gtagacgaat gtcacatgga ccctgaaagc cacaaggtca tctgcttctg tgaccacggg     3960

acggtgctgg ctgaggatgg cgtctcctgc attgtgtcac ccaccccgga gccacacctg     4020

ccactctcgc tgatcctctc tgtggtgacc tctgccctcg tggccgccct ggtcctggct     4080

ttctccggca tcatgattgt gtaccgccgg aagcaccagg agctgcaagc catgcagatg     4140

gagctgcaga gccctgagta caagctgagc aagctccgca cctcgaccat catgaccgac     4200

tacaacccca actactgctt tgctggcaag acctcctcca tcagtgacct gaaggaggtg     4260

ccgcggaaaa acatcaccct cattcggggt ctgggccatg gcgcctttgg ggaggtgtat     4320

gaaggccagg tgtccggaat gcccaacgac ccaagccccc tgcaagtggc tgtgaagacg     4380

ctgcctgaag tgtgctctga acaggacgaa ctggatttcc tcatggaagc cctgatcatc     4440

agcaaattca accaccagaa cattgttcgc tgcattgggg tgagcctgca atccctgccc     4500

cggttcatcc tgctggagct catggcgggg ggagacctca agtccttcct ccgagagacc     4560

cgccctcgcc cgagccagcc ctcctccctg gccatgctgg accttctgca cgtggctcgg     4620

gacattgcct gtggctgtca gtatttggag gaaaaccact tcatccaccg agacattgct     4680

gccagaaact gcctcttgac ctgtccaggc cctggaagag tggccaagat tggagacttc     4740

gggatggccc gagacatcta cagggcgagc tactatagaa agggaggctg tgccatgctg     4800

ccagttaagt ggatgccccc agaggccttc atggaaggaa tattcacttc taaaacagac     4860

acatggtcct ttggagtgct gctatgggaa atcttttctc ttggatatat gccatacccc     4920

agcaaaagca accaggaagt tctggagttt gtcaccagtg gaggccggat ggacccaccc     4980

aagaactgcc ctgggcctgt ataccggata atgactcagt gctggcaaca tcagcctgaa     5040

gacaggccca actttgccat cattttggag aggattgaat actgcaccca ggacccggat     5100

gtaatcaaca ccgctttgcc gatagaatat ggtccacttg tggaagagga agagaaagtg     5160

cctgtgaggc ccaaggaccc tgagggggtt cctcctctcc tggtctctca acaggcaaaa     5220

cgggaggagg agcgcagccc agctgcccca ccacctctgc ctaccacctc ctctggcaag     5280

gctgcaaaga aacccacagc tgcagagatc tctgttcgag tccctagagg gccggccgtg     5340

gaagggggac acgtgaatat ggcattctct cagtccaacc ctccttcgga gttgcacaag     5400

gtccacggat ccagaaacaa gcccaccagc ttgtggaacc caacgtacgg ctcctggttt     5460

acagagaaac ccaccaaaaa gaataatcct atagcaaaga aggagccaca cgacaggggt     5520

aacctggggc tggagggaag ctgtactgtc ccacctaacg ttgcaactgg gagacttccg     5580

ggggcctcac tgctcctaga gccctcttcg ctgactgcca atatgaagga ggtacctctg     5640

ttcaggctac gtcacttccc ttgtgggaat gtcaattacg gctaccagca acagggcttg     5700

cccttagaag ccgctactgc ccctggagct ggtcattacg aggataccat tctgaaaagc     5760

aagaatagca tgaaccagcc tgggccctga gctcggtcgc acactcactt ctcttccttg     5820

ggatccctaa gaccgtggag gagagagagg caatggctcc ttcacaaacc agagaccaaa     5880

tgtcacgttt tgttttgtgc caacctattt tgaagtacca ccaaaaaagc tgtattttga     5940

aaatgcttta gaaaggtttt gagcatgggt tcatcctatt ctttcgaaag aagaaaatat     6000

cataaaaatg agtgataaat acaaggccca gatgtggttg cataaggttt ttatgcatgt     6060

ttgttgtata cttccttatg cttctttcaa attgtgtgtg ctctgcttca atgtagtcag     6120

aattagctgc ttctatgttt catagttggg gtcatagatg tttccttgcc ttgttgatgt     6180

ggacatgagc catttgaggg gagagggaac ggaaataaag gagttatttg taatgactaa     6240


<210> 68
<211> 6221
<212> DNA
<213> Homo sapiens

<400> 68
ggggcggcag cggtggtagc agctggtacc tcccgccgcc tctgttcgga gggtcgcggg       60

gcaccgaggt gctttccggc cgccctctgg tcggccaccc aaagccgcgg gcgctgatga      120

tgggtgagga gggggcggca agatttcggg cgcccctgcc ctgaacgccc tcagctgctg      180

ccgccggggc cgctccagtg cctgcgaact ctgaggagcc gaggcgccgg tgagagcaag      240

gacgctgcaa acttgcgcag cgcgggggct gggattcacg cccagaagtt cagcaggcag      300

acagtccgaa gccttcccgc agcggagaga tagcttgagg gtgcgcaaga cggcagcctc      360

cgccctcggt tcccgcccag accgggcaga agagcttgga ggagccaaaa ggaacgcaaa      420

aggcggccag gacagcgtgc agcagctggg agccgccgtt ctcagcctta aaagttgcag      480

agattggagg ctgccccgag aggggacaga ccccagctcc gactgcgggg ggcaggagag      540

gacggtaccc aactgccacc tcccttcaac catagtagtt cctctgtacc gagcgcagcg      600

agctacagac gggggcgcgg cactcggcgc ggagagcggg aggctcaagg tcccagccag      660

tgagcccagt gtgcttgagt gtctctggac tcgcccctga gcttccaggt ctgtttcatt      720

tagactcctg ctcgcctccg tgcagttggg ggaaagcaag agacttgcgc gcacgcacag      780

tcctctggag atcaggtgga aggagccgct gggtaccaag gactgttcag agcctcttcc      840

catctcgggg agagcgaagg gtgaggctgg gcccggagag cagtgtaaac ggcctcctcc      900

ggcgggatgg gagccatcgg gctcctgtgg ctcctgccgc tgctgctttc cacggcagct      960

gtgggctccg ggatggggac cggccagcgc gcgggctccc cagctgcggg gccgccgctg     1020

cagccccggg agccactcag ctactcgcgc ctgcagagga agagtctggc agttgacttc     1080

gtggtgccct cgctcttccg tgtctacgcc cgggacctac tgctgccacc atcctcctcg     1140

gagctgaagg ctggcaggcc cgaggcccgc ggctcgctag ctctggactg cgccccgctg     1200

ctcaggttgc tggggccggc gccgggggtc tcctggaccg ccggttcacc agccccggca     1260

gaggcccgga cgctgtccag ggtgctgaag ggcggctccg tgcgcaagct ccggcgtgcc     1320

aagcagttgg tgctggagct gggcgaggag gcgatcttgg agggttgcgt cgggcccccc     1380

ggggaggcgg ctgtggggct gctccagttc aatctcagcg agctgttcag ttggtggatt     1440

cgccaaggcg aagggcgact gaggatccgc ctgatgcccg agaagaaggc gtcggaagtg     1500

ggcagagagg gaaggctgtc cgcggcaatt cgcgcctccc agccccgcct tctcttccag     1560

atcttcggga ctggtcatag ctccttggaa tcaccaacaa acatgccttc tccttctcct     1620

gattatttta catggaatct cacctggata atgaaagact ccttcccttt cctgtctcat     1680

cgcagccgat atggtctgga gtgcagcttt gacttcccct gtgagctgga gtattcccct     1740

ccactgcatg acctcaggaa ccagagctgg tcctggcgcc gcatcccctc cgaggaggcc     1800

tcccagatgg acttgctgga tgggcctggg gcagagcgtt ctaaggagat gcccagaggc     1860

tcctttctcc ttctcaacac ctcagctgac tccaagcaca ccatcctgag tccgtggatg     1920

aggagcagca gtgagcactg cacactggcc gtctcggtgc acaggcacct gcagccctct     1980

ggaaggtaca ttgcccagct gctgccccac aacgaggctg caagagagat cctcctgatg     2040

cccactccag ggaagcatgg ttggacagtg ctccagggaa gaatcgggcg tccagacaac     2100

ccatttcgag tggccctgga atacatctcc agtggaaacc gcagcttgtc tgcagtggac     2160

ttctttgccc tgaagaactg cagtgaagga acatccccag gctccaagat ggccctgcag     2220

agctccttca cttgttggaa tgggacagtc ctccagcttg ggcaggcctg tgacttccac     2280

caggactgtg cccagggaga agatgagagc cagatgtgcc ggaaactgcc tgtgggtttt     2340

tactgcaact ttgaagatgg cttctgtggc tggacccaag gcacactgtc accccacact     2400

cctcaatggc aggtcaggac cctaaaggat gcccggttcc aggaccacca agaccatgct     2460

ctattgctca gtaccactga tgtccccgct tctgaaagtg ctacagtgac cagtgctacg     2520

tttcctgcac cgatcaagag ctctccatgt gagctccgaa tgtcctggct cattcgtgga     2580

gtcttgaggg gaaacgtgtc cttggtgcta gtggagaaca aaaccgggaa ggagcaaggc     2640

aggatggtct ggcatgtcgc cgcctatgaa ggcttgagcc tgtggcagtg gatggtgttg     2700

cctctcctcg atgtgtctga caggttctgg ctgcagatgg tcgcatggtg gggacaagga     2760

tccagagcca tcgtggcttt tgacaatatc tccatcagcc tggactgcta cctcaccatt     2820

agcggagagg acaagatcct gcagaataca gcacccaaat caagaaacct gtttgagaga     2880

aacccaaaca aggagctgaa acccggggaa aattcaccaa gacagacccc catctttgac     2940

cctacagttc attggctgtt caccacatgt ggggccagcg ggccccatgg ccccacccag     3000

gcacagtgca acaacgccta ccagaactcc aacctgagcg tggaggtggg gagcgagggc     3060

cccctgaaag gcatccagat ctggaaggtg ccagccaccg acacctacag catctcgggc     3120

tacggagctg ctggcgggaa aggcgggaag aacaccatga tgcggtccca cggcgtgtct     3180

gtgctgggca tcttcaacct ggagaaggat gacatgctgt acatcctggt tgggcagcag     3240

ggagaggacg cctgccccag tacaaaccag ttaatccaga aagtctgcat tggagagaac     3300

aatgtgatag aagaagaaat ccgtgtgaac agaagcgtgc atgagtgggc aggaggcgga     3360

ggaggagggg gtggagccac ctacgtattt aagatgaagg atggagtgcc ggtgcccctg     3420

atcattgcag ccggaggtgg tggcagggcc tacggggcca agacagacac gttccaccca     3480

gagagactgg agaataactc ctcggttcta gggctaaacg gcaattccgg agccgcaggt     3540

ggtggaggtg gctggaatga taacacttcc ttgctctggg ccggaaaatc tttgcaggag     3600

ggtgccaccg gaggacattc ctgcccccag gccatgaaga agtgggggtg ggagacaaga     3660

gggggtttcg gagggggtgg aggggggtgc tcctcaggtg gaggaggcgg aggatatata     3720

ggcggcaatg cagcctcaaa caatgacccc gaaatggatg gggaagatgg ggtttccttc     3780

atcagtccac tgggcatcct gtacacccca gctttaaaag tgatggaagg ccacggggaa     3840

gtgaatatta agcattatct aaactgcagt cactgtgagg tagacgaatg tcacatggac     3900

cctgaaagcc acaaggtcat ctgcttctgt gaccacggga cggtgctggc tgaggatggc     3960

gtctcctgca ttgtgtcacc caccccggag ccacacctgc cactctcgct gatcctctct     4020

gtggtgacct ctgccctcgt ggccgccctg gtcctggctt tctccggcat catgattgtg     4080

taccgccgga agcaccagga gctgcaagcc atgcagatgg agctgcagag ccctgagtac     4140

aagctgagca agctccgcac ctcgaccatc atgaccgact acaaccccaa ctactgcttt     4200

gctggcaaga cctcctccat cagtgacctg aaggaggtgc cgcggaaaaa catcaccctc     4260

attcggggtc tgggccatgg cgcctttggg gaggtgtatg aaggccaggt gtccggaatg     4320

cccaacgacc caagccccct gcaagtggct gtgaagacgc tgcctgaagt gtgctctgaa     4380

caggacgaac tggatttcct catggaagcc ctgatcatca gcaaattcaa ccaccagaac     4440

attgttcgct gcattggggt gagcctgcaa tccctgcccc ggttcatcct gctggagctc     4500

atggcggggg gagacctcaa gtccttcctc cgagagaccc gccctcgccc gagccagccc     4560

tcctccctgg ccatgctgga ccttctgcac gtggctcggg acattgcctg tggctgtcag     4620

tatttggagg aaaaccactt catccaccga gacattgctg ccagaaactg cctcttgacc     4680

tgtccaggcc ctggaagagt ggccaagatt ggagacttcg ggatggcccg agacatctac     4740

agggcgagct actatagaaa gggaggctgt gccatgctgc cagttaagtg gatgccccca     4800

gaggccttca tggaaggaat attcacttct aaaacagaca catggtcctt tggagtgctg     4860

ctatgggaaa tcttttctct tggatatatg ccatacccca gcaaaagcaa ccaggaagtt     4920

ctggagtttg tcaccagtgg aggccggatg gacccaccca agaactgccc tgggcctgta     4980

taccggataa tgactcagtg ctggcaacat cagcctgaag acaggcccaa ctttgccatc     5040

attttggaga ggattgaata ctgcacccag gacccggatg taatcaacac cgctttgccg     5100

atagaatatg gtccacttgt ggaagaggaa gagaaagtgc ctgtgaggcc caaggaccct     5160

gagggggttc ctcctctcct ggtctctcaa caggcaaaac gggaggagga gcgcagccca     5220

gctgccccac cacctctgcc taccacctcc tctggcaagg ctgcaaagaa acccacagct     5280

gcagagatct ctgttcgagt ccctagaggg ccggccgtgg aagggggaca cgtgaatatg     5340

gcattctctc agtccaaccc tccttcggag ttgcacaagg tccacggatc cagaaacaag     5400

cccaccagct tgtggaaccc aacgtacggc tcctggttta cagagaaacc caccaaaaag     5460

aataatccta tagcaaagaa ggagccacac gacaggggta acctggggct ggagggaagc     5520

tgtactgtcc cacctaacgt tgcaactggg agacttccgg gggcctcact gctcctagag     5580

ccctcttcgc tgactgccaa tatgaaggag gtacctctgt tcaggctacg tcacttccct     5640

tgtgggaatg tcaattacgg ctaccagcaa cagggcttgc ccttagaagc cgctactgcc     5700

cctggagctg gtcattacga ggataccatt ctgaaaagca agaatagcat gaaccagcct     5760

gggccctgag ctcggtcgca cactcacttc tcttccttgg gatccctaag accgtggagg     5820

agagagaggc aatggctcct tcacaaacca gagaccaaat gtcacgtttt gttttgtgcc     5880

aacctatttt gaagtaccac caaaaaagct gtattttgaa aatgctttag aaaggttttg     5940

agcatgggtt catcctattc tttcgaaaga agaaaatatc ataaaaatga gtgataaata     6000

caaggcccag atgtggttgc ataaggtttt tatgcatgtt tgttgtatac ttccttatgc     6060

ttctttcaaa ttgtgtgtgc tctgcttcaa tgtagtcaga attagctgct tctatgtttc     6120

atagttgggg tcatagatgt ttccttgcct tgttgatgtg gacatgagcc atttgagggg     6180

agagggaacg gaaataaagg agttatttgt aatgactaaa a                         6221


<210> 69
<211> 5918
<212> DNA
<213> Mus musculus

<400> 69
gtgttcacgc ccagaagttc agcgggcagg gtgatcgatc cgaagacttc ctgcagcgga       60

ggtcacttga gggggcgcta gaaagcagcc ccctccggtg gtccttgcct agacctggga      120

aggagcgcag aggaggtgac aggagcggag gacgtgggca agacagtgac cgactcggag      180

ccacggttca cagcctggaa agttgcagaa gattggaagc taagaggaga gctctggtcg      240

ccgagggctc cttgaacggt acctaattgc cacctccctg gtccctgagc aaaggcctct      300

acaaatgggg cgcagcacgg cgagaggcgc aggatccagc tgttgagccc agggtgtctc      360

actgtctccg aactaccccc tgactttgtc ttccgttttg ctgagaaccc ttctcgcctc      420

cttgtagctt gggaaaagca agggcgctct atagtgtaca cacagtccct gagatctagt      480

ggaaggagcc attcaggacc aaggactatt tggagccctt tcctgtttgg gggagagtga      540

agggcgaggc tggaccagca agggaaggga gactagtgta aactcgccct ccagcgggat      600

gggagctgct gggttcctgt ggctgctgcc tccactgctt ttggcagcag cctcgtactc      660

cggagctgca accgatcagc gcgcgggttc cccagcctca gggcctcctc tgcagccccg      720

ggagccgctc agttattcgc gcctgcagag gaagagtctg gcagtggact tcgttgtacc      780

ctcgctcttc cgcgtctatg cccgagacct gctgctaccg cagccacggt ccccctcgga      840

gcccgaggct ggcgggctgg aggcgcgggg atcactggcc ctggattgtg agcctctgct      900

caggctgctg gggccactgc ctggaatctc ctgggcagat ggagccagtt ctcctagtcc      960

cgaggcgggt ccgacgctgt ccagggtgct gaagggaggc tcggtgcgca agctcaggcg     1020

tgccaaacag ctggtgctgg agctgggcga ggagacgatt cttgaaggct gtattggtcc     1080

cccagaggag gtagcggctg tggggatact ccagttcaac ctcagcgagc tgttcagctg     1140

gtggattctc cacggcgaag ggaggctgag gatccgcctg atgcctgaga agaaggcatc     1200

ggaagtgggc agggagggaa ggctatccag tgcgatccga gcctcccagc cccgccttct     1260

cttccagatc ttcgggacgg gacacagctc catggagtca ccctcagaaa cgccttctcc     1320

tcctggtacc ttcatgtgga atctgacctg gacgatgaaa gactccttcc ctttcctttc     1380

ccaccgcagt cgatatggtc tggagtgcag ctttgacttc ccctgtgagc tggaatattc     1440

tcctcccctg cacaaccacg ggaatcagag ctggtcctgg cgccatgtgc cctccgagga     1500

ggcctcgagg atgaacttgc tggatgggcc agaggcagag cattctcaag agatgcccag     1560

aggctccttc ctcctcctga acacctctgc agattccaag cataccattc tgagcccatg     1620

gatgaggagc agtagtgatc actgcacact ggctgtctcc gtgcacagac atctacagcc     1680

ttcggggaga tatgttgccc agctcctacc ccacaacgaa gctggaagag agattctttt     1740

ggtgcccacc ccagggaagc atggctggac agtgctgcag gggagagtcg ggcgcccagc     1800

aaacccattt cgagtggctc tggaatacat ctccagtggc aaccggagct tgtcggcggt     1860

ggatttcttt gccctgaaga actgcagtga agggacatcc ccaggctcca agatggcatt     1920

gcagagttcc ttcacttgtt ggaatgggac cgtcctccag ctcgggcaag cctgtgattt     1980

ccaccaggac tgtgcccaag gagaagatga gggccagctg tgcagtaaac ttcctgctgg     2040

attttactgt aactttgaaa atggcttctg tggctggacc caaagtccac tctcacccca     2100

tatgccccgg tggcaagtga ggaccctaag agatgcccat tcccagggcc accaaggccg     2160

tgccctgttg ctcagcacca ctgacatcct cgcttctgaa ggtgcaacag tgaccagtgc     2220

caccttccct gcaccaatga aaaattctcc ttgtgagctc cgcatgtcct ggctcatccg     2280

cggggttttg agaggaaacg tatctctggt gctggtggag aacaaaaccg gaaaggagca     2340

aagccggact gtctggcatg tcgccactga cgaaggctta agcctgtggc agcatacagt     2400

gctgtccctc ctcgatgtga ctgacaggtt ctggctgcag atagtcacat ggtggggtcc     2460

aggatccagg gcaaccgtgg gatttgacaa catttccatc agcctcgact gctaccttac     2520

catcagtgga gaggagaaaa tgtccctgaa ttcagtaccc aaatctagaa atctgtttga     2580

gaaaaaccca aacaaggagt caaaatcctg ggcaaacata tcaggaccaa ctcccatctt     2640

cgaccctaca gttcactggc tgttcaccac gtgtggggcc agtggacctc atggccccac     2700

ccaggcacag tgcaacaacg cctaccagaa ttccaacttg agcgtggtgg tgggaagtga     2760

agggcccttg aagggagtcc agatttggaa agtgccagct actgacacct acagtatctc     2820

gggctacgga gcagctggcg ggaaaggtgg gaaaaacacc atgatgcggt cccatggcgt     2880

gtctgtcctg ggcatcttca atctggagaa aggtgacaca ctctacatcc ttgtcggtca     2940

gcaaggggag gatgcctgtc ccagggcaaa ccaactaatc cagaaagtct gtgtgggtga     3000

gaacaatgtc atagaagaag agatccgagt gaacagaagc gtgcacgagt gggcaggagg     3060

aggaggaggt gggggtggag ccacctacgt gtttaagatg aaagatggcg tgcctgtacc     3120

cctgatcatt gcagctggtg gtggtggcag ggcctatggg gccaagacag aaacgttcca     3180

cccagagaga ctggagagta actcctcggt tctagggctg aacggcaatt ccggagccgc     3240

aggtggtgga ggcggctgga atgataacac ttccttgctc tgggccggaa agtctttgct     3300

ggagggtgcc gccggaggac attcctgccc ccaggccatg aagaagtggg ggtgggagac     3360

aagagggggt ttcggagggg gtggaggggg gtgctcctca ggtggaggag gcggaggata     3420

tataggtggc aacgcagcat caaacaatga ccccgaaatg gatggggaag atggggtttc     3480

cttcatcagt ccattgggta tcctgtacac cccggcctta aaagtgatgg agggccacgg     3540

ggaagtgaat atcaagcatt atctaaactg cagtcactgc gaggtagacg aatgtcacat     3600

ggaccccgag agccacaaag tcatctgctt ctgtgatcat gggaccgtgc tggctgatga     3660

tggtgtctcc tgcattgtgt cacccacccc ggagccccac ctgccgctct cattgatcct     3720

ctccgtcgtg acctctgccc tggtggctgc ccttgttctg gcattctccg gcatcatgat     3780

tgtgtaccgt cggaagcacc aggagttgca ggctatgcag atggaactgc agagccccga     3840

gtataagctg agcaagctac ggacctcgac catcatgacc gactacaacc ccaactactg     3900

cttcgctggc aagacttcct ccatcagtga cctgaaagaa gtgccacgga aaaacatcac     3960

actcatccgg ggcctaggcc atggcgcatt tggggaggtg tatgaaggcc aggtgtctgg     4020

aatgcccaat gacccaagcc ctctacaagt ggctgtaaag acgctgccag aagtgtgttc     4080

agaacaagat gagctggact ttctcatgga agctctgatc atcagcaaat tcaaccacca     4140

gaatattgtt cgctgcatcg gggtgagtct acaagccctg ccccgcttca tcctgctgga     4200

actcatggct ggcggagacc tcaagtcctt cctcagggag acacgccctc gcccgaacca     4260

acccacctcc ctggccatgc tggaccttct gcatgtggct cgggacattg cctgtggctg     4320

tcagtaccta gaggagaatc actttatcca ccgggatatt gctgctagaa actgtctgtt     4380

gacctgccca ggagctggaa gaatagcaaa gattggagac tttgggatgg cccgagatat     4440

ctacagggcc agctactacc gaaagggagg ctgcgccatg ctgccggtca agtggatgcc     4500

ccctgaagcc ttcatggaag ggatatttac ctctaaaaca gacacatggt cttttggagt     4560

gttgctatgg gaaatatttt ctcttggata tatgccgtac cccagcaaga gcaaccagga     4620

agttctggag tttgtcacca gcggaggacg gatggacccg cctaagaact gccccgggcc     4680

tgtataccgg ataatgacgc agtgctggca gcatcagcct gaagacagac ccaacttcgc     4740

catcattttg gagaggatcg aatactgcac ccaggacccc gatgtgatca acacagctct     4800

gcccatcgaa tacggtccag tagtagaaga ggaggagaaa gtgcccatgc gccccaaaga     4860

ccccgagggg atgccacctt tgctggtgtc tccccagcct gcgaagcacg aggaggcgtc     4920

cgcagctccc cagcccgcag ccctgacggc accaggccca tcggtgaaga agcccccggg     4980

tgcgggtgcg ggcgcgggcg cgggtgcggg tgccggcccg gtgccccgag gtgcggccga     5040

tcggggccac gtgaacatgg ctttctctca gcccaaccct cccccggagc tgcacaaagg     5100

cccgggatcc agaaacaagc cgaccagcct gtggaacccc acctacggct cgtggttcac     5160

cgagaagcct gccaaaaaga cccatcctcc gccaggcgcc gagccgcagg cgcgggcagg     5220

agcggccgag ggtggctgga ccgggccggg cgcggggccc cgcagagccg aggcagcgct     5280

gctgctagag ccatcggcgc tgagcgccac catgaaggag gtgccgctgt tcaggctgcg     5340

ccacttcccc tgcggcaatg tcaactatgg ttaccagcaa cagggtctcc ccttggaagc     5400

cacagccgcg ccaggggaca ccatgctgaa aagcaagaat aaggtcaccc agccggggcc     5460

ctgagccctg tactccacta gcttctcctc ctggcggagc cggagcccac ccagagggag     5520

atggacagga tggctccacc acaaacccaa gaccaaaact ttcatttttg tgccaacttg     5580

ttttgaagtg ccacatttta aaaaaaggaa acttgtgttt ttaagatgtg ttagaaggtt     5640

ttttgagcat gggttcatct atcctctcaa aagaagaaaa tgccattctt taaaaaagaa     5700

aaaaaagcaa tcagtgcaag gcccagattg gttgcgccaa gttttcgtgc atggtctgct     5760

gtacagtccc ctaaggcttc tttccgattt ttgtgtgcgc tctgcttccg cgtagtcaga     5820

aatagctgct tccatgtctc atagggggag tcctaggtgt ttcctttgcc ttatgaatat     5880

gaaccactcg aggggcgggc gagggaacag aaataaag                             5918


<210> 70
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 70
gacatccaga tgactcagtc tccagcctcc ctggctgcat ctgtgggaga aactgtcacc       60

atcacatgtc gagcaagtga gaacatttac tacagtttag catggtatca gcagaagcaa      120

gggaaatctc ctcagctcct gatctataat gcaaacagct tggaagatgg tgtcccatcg      180

aggttcagtg gcagtggatc tgggacacag tattctatga agatcaacag catgcagcct      240

gaagataccg caacttattt ctgtaaacag gcttatgacg ttccattcac gttcggctcg      300

gggacaaagt tggaaataaa acgg                                             324


<210> 71
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 71
gctatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gtgtaagtca gggcattagc aattctttaa actggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctattac acatcaagtt tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tgggacagat tattctctca ccatcagcaa cctggaacct      240

gaagatattg ccacttacta ttgtcagcag tatagtaagc ttccgctcac gttcggtgct      300

gggaccaagc tggagctgaa acgg                                             324


<210> 72
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 72
gacattgtga tgacccagtc tcaaagattc atgtccacat cagtaggaga cagggtcagc       60

gtcacctgca aggccagtca gaatgtgggt actaatgtag cctggtatca acagaaacca      120

gggcaatctc ctaaagcact gatttactcg gcatcctacc ggtacagtgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccgtcagcaa tgtgcagtct      240

gaagacttgg cagagtattt ctgtcagcaa tataacagct atccgtacat gtacacgttc      300

ggagggggga ccaagctgga aataaaacgg                                       330


<210> 73
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 73
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca gagccagcga aagtgttgat aattatggca ttagttttat gaactggttc      120

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa ccaaggatcc      180

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat      240

cctatggagg aggatgatac tgcaatgtat ttctgtcagc aaagtaagga ggttccgtgg      300

acgttcggtg gaggcaccaa gctggaaatc aaacgg                                336


<210> 74
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 74
gacattgtga tgacccagtc tcaaagattc atgtccacat cagtaggaga cagggtcagc       60

gtcacctgca aggccagtca gaatgtgggt actaatgtag cctggtatca acagaaacca      120

gggcaatctc ctaaagcact gatttactcg gcatcctacc ggtacagtgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct      240

gaagacttgg cagagtattt ctgtcaacaa tataacagct atccgtacat gtacacgttc      300

ggagggggga ccaagctgga aataaaacgg                                       330


<210> 75
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 75
gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcagc       60

atcacctgta aggccagtca gaatgtgggt actgctgtag cctggtatca actgaaacca      120

ggacaatctc ctaaactact gatttactcg gcatccaatc ggttcactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tatgcagtct      240

gaagacctgg cagattattt ctgccagcaa tatagcagct atcctctcac gttcggctcg      300

gggacaaagt tggaaataaa acgg                                             324


<210> 76
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 76
gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcagc       60

gtcacctgca aggccagtca gaatgtgggt actaatgtag cctggtatca acagaaacca      120

gggcactctc ctaaagcact gatttactcg gcatcctacc ggtacagtgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct      240

gaagacttgg cagagtattt ctgtcagcga tataacagct atccgtacat gttcacgttc      300

ggagggggga ccaagctgga aataaaacgg                                       330


<210> 77
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 77
caggttcagc tgcagcagtc tggggctgag ctggtgaagc ctggggcctc agtgaagatt       60

tcctgcaaag cttctggcta cgcattcagt agctactgga tgaactgggt gaagcagagg      120

cctggaaagg gtcttgagtg gattggacag atttatcctg gagatggtga tactaactac      180

aacggaaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac ctctgaggac tctgcggtct atttctgtgc ctcttattac      300

tacggtagta aggcttactg gggccaaggg actctggtca ctgtctctgc a               351


<210> 78
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 78
caggtccaac tgcagcagcc tggggctgag tttgtgaagc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggcta caccttcacc agctactgga tgcactgggt gaagcagagg      120

cctggacgag gccttgagtg gattggaagg attgatccta atagtggtgg tactaagtac      180

aatgagaagt tcaagagcaa ggccacactg actgtagaca aaccctccag cacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgcggtct attattgtgc aagagattac      300

tacggtagta gctaccggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      360


<210> 79
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 79
caggtccagc tgcagcagtc tggggctgaa ctggcaaaac ctggggcctc agtgaagctg       60

tcctgcaagg cttctggcta cacctttact aactactgga tgcactgggt aaaacagagg      120

cctggacagg gtctggaatg gattggatac attaatccta gcagtggtta tactaagtac      180

aatcagaagt tcaaggacaa ggccacattg actgcagaca aatcctccag cacagcctac      240

atgcagctga gcagcctgac atatgaggac tctgcagtct attactgtgc aagagattac      300

tacggtagta gctcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      360


<210> 80
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 80
caggttcagc tgcaacagtc tggggctgag ctggtgaagc ctggggcctc agtgaagatt       60

tcctgcaaag cttctggcta cgcattcagt agctactggg tgaactgggt gaagcagagg      120

cctggaaagg gtcttgagtg gattggacag atttatcctg gagatggtga tactaactac      180

aacggaaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac ctctgaggac tctgcggtct atttctgtgc aagatcaaga      300

gggtatttct acggtagtac ctacgactcc tggggccaag gcaccactct cacagtctcc      360

tca                                                                    363


<210> 81
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 81
caggtccagc tgcagcagtc tggggctgaa ctggcaaaac ctggggcctc agtgaagctg       60

tcctgcaagg cttctggcta cacctttact agctactgga tgcactgggt aaaacagagg      120

cctggacagg gtctggaatg gattggatac attaagccta gcagtggtta tactaagtac      180

aatcagaagt tcaaggacaa ggccacattg actgcagaca aatcctccag cacagcctac      240

atgcagctga gcagcctgac atatgaggac tctgcagtct attactgtgc aagagattac      300

tacggtagta gctcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      360


<210> 82
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 82
gacgtgaagc tggtggagtc tggggaaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt agctatgcca tgtcttgggt tcgccagact      120

ccagagaaga ggctggagtg ggtcacatac attagtagtg gtggtgatta catctactat      180

gcagacactg tgaagggccg attcaccatc tccagagaca atgccaggaa caccctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acagccatgt attactgtac aagagagcgg      300

atatggttac gacggttctt cgatgtctgg ggcacaggga ccacggtcac cgtctcctca      360


<210> 83
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 83
caggtccagc tgcagcagtc tggggctgaa ctggcaaaac ctggggcctc agtgaagctg       60

tcctgcaagg cttctggcta cacctttact agctactgga tgcactgggt aaaacagagg      120

cctggacagg gtctggaatg gattggatac attaatccta gcagtggtta tactaagtac      180

aatcagaagt tcaaggacaa ggccacattg actgcagaca aatcctccag cacagcctac      240

atgcagctga gcagcctgac atttgaggac tctgcagtct attactgtgc aagagattac      300

tacggtagta gctcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      360


<210> 84
<211> 680
<212> PRT
<213> Homo sapiens

<400> 84
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn 
1               5                   10                  15      


Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys 
            20                  25                  30          


Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser 
        35                  40                  45              


Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala 
    50                  55                  60                  


Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys 
65                  70                  75                  80  


Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro 
                85                  90                  95      


Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser 
            100                 105                 110         


Gly Gln His Leu Val Val Tyr Arg Arg Lys His Gln Glu Leu Gln Ala 
        115                 120                 125             


Met Gln Met Glu Leu Gln Ser Pro Glu Tyr Lys Leu Ser Lys Leu Arg 
    130                 135                 140                 


Thr Ser Thr Ile Met Thr Asp Tyr Asn Pro Asn Tyr Cys Phe Ala Gly 
145                 150                 155                 160 


Lys Thr Ser Ser Ile Ser Asp Leu Lys Glu Val Pro Arg Lys Asn Asn 
                165                 170                 175     


Thr Leu Ile Arg Gly Leu Gly His Gly Ala Phe Gly Glu Val Tyr Glu 
            180                 185                 190         


Gly Gln Val Ser Gly Met Pro Asn Asp Pro Ser Pro Leu Gln Val Ala 
        195                 200                 205             


Val Lys Thr Leu Pro Glu Val Cys Ser Glu Gln Asp Glu Leu Asp Phe 
    210                 215                 220                 


Leu Met Glu Ala Leu Ile Ile Ser Lys Phe Asn His Gln Asn Ile Val 
225                 230                 235                 240 


Arg Cys Ile Gly Val Ser Leu Gln Ser Leu Pro Arg Phe Ile Leu Leu 
                245                 250                 255     


Glu Leu Met Ala Gly Gly Asp Leu Lys Ser Phe Leu Arg Glu Thr Arg 
            260                 265                 270         


Pro Arg Pro Ser Gln Pro Ser Ser Leu Ala Met Leu Asp Leu Leu His 
        275                 280                 285             


Val Ala Arg Asp Ile Ala Cys Gly Cys Gln Tyr Leu Glu Glu Asn His 
    290                 295                 300                 


Phe Ile His Arg Asp Ile Ala Ala Arg Asn Cys Leu Leu Thr Cys Pro 
305                 310                 315                 320 


Gly Pro Gly Arg Val Ala Lys Ile Gly Asp Phe Gly Met Ala Arg Asp 
                325                 330                 335     


Ile Tyr Arg Ala Ser Tyr Tyr Arg Lys Gly Gly Cys Ala Met Leu Pro 
            340                 345                 350         


Val Lys Trp Met Pro Pro Glu Ala Phe Met Glu Gly Ile Phe Thr Ser 
        355                 360                 365             


Lys Thr Asp Thr Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser 
    370                 375                 380                 


Leu Gly Tyr Met Pro Tyr Pro Ser Lys Ser Asn Gln Glu Val Leu Glu 
385                 390                 395                 400 


Phe Val Thr Ser Gly Gly Arg Met Asp Pro Pro Lys Asn Cys Pro Gly 
                405                 410                 415     


Pro Val Tyr Arg Ile Met Thr Gln Cys Trp Gln His Gln Pro Glu Asp 
            420                 425                 430         


Arg Pro Asn Phe Ala Ile Ile Leu Glu Arg Ile Glu Tyr Cys Thr Gln 
        435                 440                 445             


Asp Pro Asp Val Ile Asn Thr Ala Leu Pro Ile Glu Tyr Gly Pro Leu 
    450                 455                 460                 


Val Glu Glu Glu Glu Lys Val Pro Val Arg Pro Lys Asp Pro Glu Gly 
465                 470                 475                 480 


Val Pro Pro Leu Leu Val Ser Gln Gln Ala Lys Arg Glu Glu Glu Arg 
                485                 490                 495     


Ser Pro Ala Ala Pro Pro Pro Leu Pro Thr Thr Ser Ser Gly Lys Ala 
            500                 505                 510         


Ala Lys Lys Pro Thr Ala Ala Glu Val Ser Val Arg Val Pro Arg Gly 
        515                 520                 525             


Pro Ala Val Glu Gly Gly His Val Asn Met Ala Phe Ser Gln Ser Asn 
    530                 535                 540                 


Pro Pro Ser Glu Leu His Arg Val His Gly Ser Arg Asn Lys Pro Thr 
545                 550                 555                 560 


Ser Leu Trp Asn Pro Thr Tyr Gly Ser Trp Phe Thr Glu Lys Pro Thr 
                565                 570                 575     


Lys Lys Asn Asn Pro Ile Ala Lys Lys Glu Pro His Glu Arg Gly Asn 
            580                 585                 590         


Leu Gly Leu Glu Gly Ser Cys Thr Val Pro Pro Asn Val Ala Thr Gly 
        595                 600                 605             


Arg Leu Pro Gly Ala Ser Leu Leu Leu Glu Pro Ser Ser Leu Thr Ala 
    610                 615                 620                 


Asn Met Lys Glu Val Pro Leu Phe Arg Leu Arg His Phe Pro Cys Gly 
625                 630                 635                 640 


Asn Val Asn Tyr Gly Tyr Gln Gln Gln Gly Leu Pro Leu Glu Ala Ala 
                645                 650                 655     


Thr Ala Pro Gly Ala Gly His Tyr Glu Asp Thr Ile Leu Lys Ser Lys 
            660                 665                 670         


Asn Ser Met Asn Gln Pro Gly Pro 
        675                 680 


<210> 85
<211> 680
<212> PRT
<213> Homo sapiens

<400> 85
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn 
1               5                   10                  15      


Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys 
            20                  25                  30          


Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser 
        35                  40                  45              


Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala 
    50                  55                  60                  


Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys 
65                  70                  75                  80  


Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro 
                85                  90                  95      


Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser 
            100                 105                 110         


Gly Gln His Leu Val Val Tyr Arg Arg Lys His Gln Glu Leu Gln Ala 
        115                 120                 125             


Met Gln Met Glu Leu Gln Ser Pro Glu Tyr Lys Leu Ser Lys Leu Arg 
    130                 135                 140                 


Thr Ser Thr Ile Met Thr Asp Tyr Asn Pro Asn Tyr Cys Phe Ala Gly 
145                 150                 155                 160 


Lys Thr Ser Ser Ile Ser Asp Leu Lys Glu Val Pro Arg Lys Asn Ile 
                165                 170                 175     


Thr Leu Ile Arg Gly Leu Gly His Gly Ala Phe Gly Glu Val Tyr Glu 
            180                 185                 190         


Gly Gln Val Ser Gly Met Pro Asn Asp Pro Ser Pro Leu Gln Val Ala 
        195                 200                 205             


Val Lys Thr Leu Pro Glu Val Cys Ser Glu Gln Asp Glu Leu Asp Phe 
    210                 215                 220                 


Leu Met Glu Ala Leu Ile Ile Ser Lys Phe Asn His Gln Asn Ile Val 
225                 230                 235                 240 


Arg Cys Ile Gly Val Ser Leu Gln Ser Leu Pro Arg Phe Ile Leu Leu 
                245                 250                 255     


Glu Leu Met Ala Gly Gly Asp Leu Lys Ser Phe Leu Arg Glu Thr Arg 
            260                 265                 270         


Pro Arg Pro Ser Gln Pro Ser Ser Leu Ala Met Leu Asp Leu Leu His 
        275                 280                 285             


Val Ala Arg Asp Ile Ala Cys Gly Cys Gln Tyr Leu Glu Glu Asn His 
    290                 295                 300                 


Phe Ile His Arg Asp Ile Ala Ala Arg Asn Cys Leu Leu Thr Cys Pro 
305                 310                 315                 320 


Gly Pro Gly Arg Val Ala Lys Ile Gly Asp Phe Gly Met Ala Arg Asp 
                325                 330                 335     


Ile Tyr Arg Ala Ser Tyr Tyr Arg Lys Gly Gly Cys Ala Met Leu Pro 
            340                 345                 350         


Val Lys Trp Met Pro Pro Glu Ala Phe Met Glu Gly Ile Phe Thr Ser 
        355                 360                 365             


Lys Thr Asp Thr Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser 
    370                 375                 380                 


Leu Gly Tyr Met Pro Tyr Pro Ser Lys Ser Asn Gln Glu Val Leu Glu 
385                 390                 395                 400 


Phe Val Thr Ser Gly Gly Arg Met Asp Pro Pro Lys Asn Cys Pro Gly 
                405                 410                 415     


Pro Val Tyr Arg Ile Met Thr Gln Cys Trp Gln His Gln Pro Glu Asp 
            420                 425                 430         


Arg Pro Asn Phe Ala Ile Ile Leu Glu Arg Ile Glu Tyr Cys Thr Gln 
        435                 440                 445             


Asp Pro Asp Val Ile Asn Thr Ala Leu Pro Ile Glu Tyr Gly Pro Leu 
    450                 455                 460                 


Val Glu Glu Glu Glu Lys Val Pro Val Arg Pro Lys Asp Pro Glu Gly 
465                 470                 475                 480 


Val Pro Pro Leu Leu Val Ser Gln Gln Ala Lys Arg Glu Glu Glu Arg 
                485                 490                 495     


Ser Pro Ala Ala Pro Pro Pro Leu Pro Thr Thr Ser Ser Gly Lys Ala 
            500                 505                 510         


Ala Lys Lys Pro Thr Ala Ala Glu Val Ser Val Arg Val Pro Arg Gly 
        515                 520                 525             


Pro Ala Val Glu Gly Gly His Val Asn Met Ala Phe Ser Gln Ser Asn 
    530                 535                 540                 


Pro Pro Ser Glu Leu His Lys Val His Gly Ser Arg Asn Lys Pro Thr 
545                 550                 555                 560 


Ser Leu Trp Asn Pro Thr Tyr Gly Ser Trp Phe Thr Glu Lys Pro Thr 
                565                 570                 575     


Lys Lys Asn Asn Pro Ile Ala Lys Lys Glu Pro His Asp Arg Gly Asn 
            580                 585                 590         


Leu Gly Leu Glu Gly Ser Cys Thr Val Pro Pro Asn Val Ala Thr Gly 
        595                 600                 605             


Arg Leu Pro Gly Ala Ser Leu Leu Leu Glu Pro Ser Ser Leu Thr Ala 
    610                 615                 620                 


Asn Met Lys Glu Val Pro Leu Phe Arg Leu Arg His Phe Pro Cys Gly 
625                 630                 635                 640 


Asn Val Asn Tyr Gly Tyr Gln Gln Gln Gly Leu Pro Leu Glu Ala Ala 
                645                 650                 655     


Thr Ala Pro Gly Ala Gly His Tyr Glu Asp Thr Ile Leu Lys Ser Lys 
            660                 665                 670         


Asn Ser Met Asn Gln Pro Gly Pro 
        675                 680 


<210> 86
<211> 680
<212> PRT
<213> Homo sapiens

<400> 86
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn 
1               5                   10                  15      


Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys 
            20                  25                  30          


Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser 
        35                  40                  45              


Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala 
    50                  55                  60                  


Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys 
65                  70                  75                  80  


Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro 
                85                  90                  95      


Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser 
            100                 105                 110         


Gly Gln His Leu Val Val Tyr Arg Arg Lys His Gln Glu Leu Gln Ala 
        115                 120                 125             


Met Gln Met Glu Leu Gln Ser Pro Glu Tyr Lys Leu Ser Lys Leu Arg 
    130                 135                 140                 


Thr Ser Thr Ile Met Thr Asp Tyr Asn Pro Asn Tyr Cys Phe Ala Gly 
145                 150                 155                 160 


Lys Thr Ser Ser Ile Ser Asp Leu Lys Glu Val Pro Arg Lys Asn Ile 
                165                 170                 175     


Thr Leu Ile Arg Gly Leu Gly His Gly Ala Phe Gly Glu Val Tyr Glu 
            180                 185                 190         


Gly Gln Val Ser Gly Met Pro Asn Asp Pro Ser Pro Leu Gln Val Ala 
        195                 200                 205             


Val Lys Thr Leu Pro Glu Val Cys Ser Glu Gln Asp Glu Leu Asp Phe 
    210                 215                 220                 


Leu Met Glu Ala Leu Ile Ile Ser Lys Phe Asn His Gln Asn Ile Val 
225                 230                 235                 240 


Arg Cys Ile Gly Val Ser Leu Gln Ser Leu Pro Arg Phe Ile Leu Leu 
                245                 250                 255     


Glu Leu Met Ala Gly Gly Asp Leu Lys Ser Phe Leu Arg Glu Thr Arg 
            260                 265                 270         


Pro Arg Pro Ser Gln Pro Ser Ser Leu Ala Met Leu Asp Leu Leu His 
        275                 280                 285             


Val Ala Arg Asp Ile Ala Cys Gly Cys Gln Tyr Leu Glu Glu Asn His 
    290                 295                 300                 


Phe Ile His Arg Asp Ile Ala Ala Arg Asn Cys Leu Leu Thr Cys Pro 
305                 310                 315                 320 


Gly Pro Gly Arg Val Ala Lys Ile Gly Asp Phe Gly Met Ala Arg Asp 
                325                 330                 335     


Ile Tyr Arg Ala Ser Tyr Tyr Arg Lys Gly Gly Cys Ala Met Leu Pro 
            340                 345                 350         


Val Lys Trp Met Pro Pro Glu Ala Phe Met Glu Gly Ile Phe Thr Ser 
        355                 360                 365             


Lys Thr Asp Thr Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser 
    370                 375                 380                 


Leu Gly Tyr Met Pro Tyr Pro Ser Lys Ser Asn Gln Glu Val Leu Glu 
385                 390                 395                 400 


Phe Val Thr Ser Gly Gly Arg Met Asp Pro Pro Lys Asn Cys Pro Gly 
                405                 410                 415     


Pro Val Tyr Arg Ile Met Thr Gln Cys Trp Gln His Gln Pro Glu Asp 
            420                 425                 430         


Arg Pro Asn Phe Ala Ile Ile Leu Glu Arg Ile Glu Tyr Cys Thr Gln 
        435                 440                 445             


Asp Pro Asp Val Ile Asn Thr Ala Leu Pro Ile Glu Tyr Gly Pro Leu 
    450                 455                 460                 


Val Glu Glu Glu Glu Lys Val Pro Val Arg Pro Lys Asp Pro Glu Gly 
465                 470                 475                 480 


Val Pro Pro Leu Leu Val Ser Gln Gln Ala Lys Arg Glu Glu Glu Arg 
                485                 490                 495     


Ser Pro Ala Ala Pro Pro Pro Leu Pro Thr Thr Ser Ser Gly Lys Ala 
            500                 505                 510         


Ala Lys Lys Pro Thr Ala Ala Glu Val Ser Val Arg Val Pro Arg Gly 
        515                 520                 525             


Pro Ala Val Glu Gly Gly His Val Asn Met Ala Phe Ser Gln Ser Asn 
    530                 535                 540                 


Pro Pro Ser Glu Leu His Lys Val His Gly Ser Arg Asn Lys Pro Thr 
545                 550                 555                 560 


Ser Leu Trp Asn Pro Thr Tyr Gly Ser Trp Phe Thr Glu Lys Pro Thr 
                565                 570                 575     


Lys Lys Asn Asn Pro Ile Ala Lys Lys Glu Pro His Asp Arg Gly Asn 
            580                 585                 590         


Leu Gly Leu Glu Gly Ser Cys Thr Val Pro Pro Asn Val Ala Thr Gly 
        595                 600                 605             


Arg Leu Pro Gly Ala Ser Leu Leu Leu Glu Pro Ser Ser Leu Thr Ala 
    610                 615                 620                 


Asn Met Lys Glu Val Pro Leu Phe Arg Leu Arg His Phe Pro Cys Gly 
625                 630                 635                 640 


Asn Val Asn Tyr Gly Tyr Gln Gln Gln Gly Leu Pro Leu Glu Ala Ala 
                645                 650                 655     


Thr Ala Pro Gly Ala Gly His Tyr Glu Asp Thr Ile Leu Lys Ser Lys 
            660                 665                 670         


Asn Ser Met Asn Gln Pro Gly Pro 
        675                 680 


<210> 87
<211> 2043
<212> DNA
<213> Homo sapiens

<400> 87
atggaagatt cgatggacat ggacatgagc cccctgaggc cccagaacta tcttttcggt       60

tgtgaactaa aggccgacaa agattatcac tttaaggtgg ataatgatga aaatgagcac      120

cagttatctt taagaacggt cagtttaggg gctggtgcaa aggatgagtt gcacattgtt      180

gaagcagagg caatgaatta cgaaggcagt ccaattaaag taacactggc aactttgaaa      240

atgtctgtac agccaacggt ttcccttggg ggctttgaaa taacaccacc agtggtctta      300

aggttgaagt gtggttcagg gccagtgcat attagtggac agcacttagt agtgtaccgc      360

cggaagcacc aggagctgca agccatgcag atggagctgc agagccctga gtacaagctg      420

agcaagctcc gcacctcgac catcatgacc gactacaacc ccaactactg ctttgctggc      480

aagacctcct ccatcagtga cctgaaggag gtgccgcgga aaaacatcac cctcattcgg      540

ggtctgggcc atggcgcctt tggggaggtg tatgaaggcc aggtgtccgg aatgcccaac      600

gacccaagcc ccctgcaagt ggctgtgaag acgctgcctg aagtgtgctc tgaacaggac      660

gaactggatt tcctcatgga agccctgatc atcagcaaat tcaaccacca gaacattgtt      720

cgctgcattg gggtgagcct gcaatccctg ccccggttca tcctgctgga gctcatggcg      780

gggggagacc tcaagtcctt cctccgagag acccgccctc gcccgagcca gccctcctcc      840

ctggccatgc tggaccttct gcacgtggct cgggacattg cctgtggctg tcagtatttg      900

gaggaaaacc acttcatcca ccgagacatt gctgccagaa actgcctctt gacctgtcca      960

ggccctggaa gagtggccaa gattggagac ttcgggatgg cccgagacat ctacagggcg     1020

agctactata gaaagggagg ctgtgccatg ctgccagtta agtggatgcc cccagaggcc     1080

ttcatggaag gaatattcac ttctaaaaca gacacatggt cctttggagt gctgctatgg     1140

gaaatctttt ctcttggata tatgccatac cccagcaaaa gcaaccagga agttctggag     1200

tttgtcacca gtggaggccg gatggaccca cccaagaact gccctgggcc tgtataccgg     1260

ataatgactc agtgctggca acatcagcct gaagacaggc ccaactttgc catcattttg     1320

gagaggattg aatactgcac ccaggacccg gatgtaatca acaccgcttt gccgatagaa     1380

tatggtccac ttgtggaaga ggaagagaaa gtgcctgtga ggcccaagga ccctgagggg     1440

gttcctcctc tcctggtctc tcaacaggca aaacgggagg aggagcgcag cccagctgcc     1500

ccaccacctc tgcctaccac ctcctctggc aaggctgcaa agaaacccac agctgcagag     1560

gtctctgttc gagtccctag agggccggcc gtggaagggg gacacgtgaa tatggcattc     1620

tctcagtcca accctccttc ggagttgcac aaggtccacg gatccagaaa caagcccacc     1680

agcttgtgga acccaacgta cggctcctgg tttacagaga aacccaccaa aaagaataat     1740

cctatagcaa agaaggagcc acacgacagg ggtaacctgg ggctggaggg aagctgtact     1800

gtcccaccta acgttgcaac tgggagactt ccgggggcct cactgctcct agagccctct     1860

tcgctgactg ccaatatgaa ggaggtacct ctgttcaggc tacgtcactt cccttgtggg     1920

aatgtcaatt acggctacca gcaacagggc ttgcccttag aagccgctac tgcccctgga     1980

gctggtcatt acgaggatac cattctgaaa agcaagaata gcatgaacca gcctgggccc     2040

tga                                                                   2043


<210> 88
<211> 1129
<212> PRT
<213> Homo sapiens

<400> 88
Met Asp Gly Phe Ala Gly Ser Leu Asp Asp Ser Ile Ser Ala Ala Ser 
1               5                   10                  15      


Thr Ser Asp Val Gln Asp Arg Leu Ser Ala Leu Glu Ser Arg Val Gln 
            20                  25                  30          


Gln Gln Glu Asp Glu Ile Thr Val Leu Lys Ala Ala Leu Ala Asp Val 
        35                  40                  45              


Leu Arg Arg Leu Ala Ile Ser Glu Asp His Val Ala Ser Val Lys Lys 
    50                  55                  60                  


Ser Val Ser Ser Lys Gly Gln Pro Ser Pro Arg Ala Val Ile Pro Met 
65                  70                  75                  80  


Ser Cys Ile Thr Asn Gly Ser Gly Ala Asn Arg Lys Pro Ser His Thr 
                85                  90                  95      


Ser Ala Val Ser Ile Ala Gly Lys Glu Thr Leu Ser Ser Ala Ala Lys 
            100                 105                 110         


Ser Gly Thr Glu Lys Lys Lys Glu Lys Pro Gln Gly Gln Arg Glu Lys 
        115                 120                 125             


Lys Glu Glu Ser His Ser Asn Asp Gln Ser Pro Gln Ile Arg Ala Ser 
    130                 135                 140                 


Pro Ser Pro Gln Pro Ser Ser Gln Pro Leu Gln Ile His Arg Gln Thr 
145                 150                 155                 160 


Pro Glu Ser Lys Asn Ala Thr Pro Thr Lys Ser Ile Lys Arg Pro Ser 
                165                 170                 175     


Pro Ala Glu Lys Ser His Asn Ser Trp Glu Asn Ser Asp Asp Ser Arg 
            180                 185                 190         


Asn Lys Leu Ser Lys Ile Pro Ser Thr Pro Lys Leu Ile Pro Lys Val 
        195                 200                 205             


Thr Lys Thr Ala Asp Lys His Lys Asp Val Ile Ile Asn Gln Glu Gly 
    210                 215                 220                 


Glu Tyr Ile Lys Met Phe Met Arg Gly Arg Pro Ile Thr Met Phe Ile 
225                 230                 235                 240 


Pro Ser Asp Val Asp Asn Tyr Asp Asp Ile Arg Thr Glu Leu Pro Pro 
                245                 250                 255     


Glu Lys Leu Lys Leu Glu Trp Ala Tyr Gly Tyr Arg Gly Lys Asp Cys 
            260                 265                 270         


Arg Ala Asn Val Tyr Leu Leu Pro Thr Gly Glu Ile Val Tyr Phe Ile 
        275                 280                 285             


Ala Ser Val Val Val Leu Phe Asn Tyr Glu Glu Arg Thr Gln Arg His 
    290                 295                 300                 


Tyr Leu Gly His Thr Asp Cys Val Lys Cys Leu Ala Ile His Pro Asp 
305                 310                 315                 320 


Lys Ile Arg Ile Ala Thr Gly Gln Ile Ala Gly Val Asp Lys Asp Gly 
                325                 330                 335     


Arg Pro Leu Gln Pro His Val Arg Val Trp Asp Ser Val Thr Leu Ser 
            340                 345                 350         


Thr Leu Gln Ile Ile Gly Leu Gly Thr Phe Glu Arg Gly Val Gly Cys 
        355                 360                 365             


Leu Asp Phe Ser Lys Ala Asp Ser Gly Val His Leu Cys Val Ile Asp 
    370                 375                 380                 


Asp Ser Asn Glu His Met Leu Thr Val Trp Asp Trp Gln Arg Lys Ala 
385                 390                 395                 400 


Lys Gly Ala Glu Ile Lys Thr Thr Asn Glu Val Val Leu Ala Val Glu 
                405                 410                 415     


Phe His Pro Thr Asp Ala Asn Thr Ile Ile Thr Cys Gly Lys Ser His 
            420                 425                 430         


Ile Phe Phe Trp Thr Trp Ser Gly Asn Ser Leu Thr Arg Lys Gln Gly 
        435                 440                 445             


Ile Phe Gly Lys Tyr Glu Lys Pro Lys Phe Val Gln Cys Leu Ala Phe 
    450                 455                 460                 


Leu Gly Asn Gly Asp Val Leu Thr Gly Asp Ser Gly Gly Val Met Leu 
465                 470                 475                 480 


Ile Trp Ser Lys Thr Thr Val Glu Pro Thr Pro Gly Lys Gly Pro Lys 
                485                 490                 495     


Gly Val Tyr Gln Ile Ser Lys Gln Ile Lys Ala His Asp Gly Ser Val 
            500                 505                 510         


Phe Thr Leu Cys Gln Met Arg Asn Gly Met Leu Leu Thr Gly Gly Gly 
        515                 520                 525             


Lys Asp Arg Lys Ile Ile Leu Trp Asp His Asp Leu Asn Pro Glu Arg 
    530                 535                 540                 


Glu Ile Glu Phe Ser Ala Ser Arg Ala Arg Leu Pro Gly His Val Ala 
545                 550                 555                 560 


Ala Asp His Pro Pro Ala Val Tyr Arg Arg Lys His Gln Glu Leu Gln 
                565                 570                 575     


Ala Met Gln Met Glu Leu Gln Ser Pro Glu Tyr Lys Leu Ser Lys Leu 
            580                 585                 590         


Arg Thr Ser Thr Ile Met Thr Asp Tyr Asn Pro Asn Tyr Cys Phe Ala 
        595                 600                 605             


Gly Lys Thr Ser Ser Ile Ser Asp Leu Lys Glu Val Pro Arg Lys Asn 
    610                 615                 620                 


Ile Thr Leu Ile Arg Gly Leu Gly His Gly Ala Phe Gly Glu Val Tyr 
625                 630                 635                 640 


Glu Gly Gln Val Ser Gly Met Pro Asn Asp Pro Ser Pro Leu Gln Val 
                645                 650                 655     


Ala Val Lys Thr Leu Pro Glu Val Cys Ser Glu Gln Asp Glu Leu Asp 
            660                 665                 670         


Phe Leu Met Glu Ala Leu Ile Ile Ser Lys Phe Asn His Gln Asn Ile 
        675                 680                 685             


Val Arg Cys Ile Gly Val Ser Leu Gln Ser Leu Pro Arg Phe Ile Leu 
    690                 695                 700                 


Leu Glu Leu Met Ala Gly Gly Asp Leu Lys Ser Phe Leu Arg Glu Thr 
705                 710                 715                 720 


Arg Pro Arg Pro Ser Gln Pro Ser Ser Leu Ala Met Leu Asp Leu Leu 
                725                 730                 735     


His Val Ala Arg Asp Ile Ala Cys Gly Cys Gln Tyr Leu Glu Glu Asn 
            740                 745                 750         


His Phe Ile His Arg Asp Ile Ala Ala Arg Asn Cys Leu Leu Thr Cys 
        755                 760                 765             


Pro Gly Pro Gly Arg Val Ala Lys Ile Gly Asp Phe Gly Met Ala Arg 
    770                 775                 780                 


Asp Ile Tyr Arg Ala Ser Tyr Tyr Arg Lys Gly Gly Cys Ala Met Leu 
785                 790                 795                 800 


Pro Val Lys Trp Met Pro Pro Glu Ala Phe Met Glu Gly Ile Phe Thr 
                805                 810                 815     


Ser Lys Thr Asp Thr Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe 
            820                 825                 830         


Ser Leu Gly Tyr Met Pro Tyr Pro Ser Lys Ser Asn Gln Glu Val Leu 
        835                 840                 845             


Glu Phe Val Thr Ser Gly Gly Arg Met Asp Pro Pro Lys Asn Cys Pro 
    850                 855                 860                 


Gly Pro Val Tyr Arg Ile Met Thr Gln Cys Trp Gln His Gln Pro Glu 
865                 870                 875                 880 


Asp Arg Pro Asn Phe Ala Ile Ile Leu Glu Arg Ile Glu Tyr Cys Thr 
                885                 890                 895     


Gln Asp Pro Asp Val Ile Asn Thr Ala Leu Pro Ile Glu Tyr Gly Pro 
            900                 905                 910         


Leu Val Glu Glu Glu Glu Lys Val Pro Val Arg Pro Lys Asp Pro Glu 
        915                 920                 925             


Gly Val Pro Pro Leu Leu Val Ser Gln Gln Ala Lys Arg Glu Glu Glu 
    930                 935                 940                 


Arg Ser Pro Ala Ala Pro Pro Pro Leu Pro Thr Thr Ser Ser Gly Lys 
945                 950                 955                 960 


Ala Ala Lys Lys Pro Thr Ala Ala Glu Ile Ser Val Arg Val Pro Arg 
                965                 970                 975     


Gly Pro Ala Val Glu Gly Gly His Val Asn Met Ala Phe Ser Gln Ser 
            980                 985                 990         


Asn Pro Pro Ser Glu Leu His Lys  Val His Gly Ser Arg  Asn Lys Pro 
        995                 1000                 1005             


Thr Ser  Leu Trp Asn Pro Thr  Tyr Gly Ser Trp Phe  Thr Glu Lys 
    1010                 1015                 1020             


Pro Thr  Lys Lys Asn Asn Pro  Ile Ala Lys Lys Glu  Pro His Asp 
    1025                 1030                 1035             


Arg Gly  Asn Leu Gly Leu Glu  Gly Ser Cys Thr Val  Pro Pro Asn 
    1040                 1045                 1050             


Val Ala  Thr Gly Arg Leu Pro  Gly Ala Ser Leu Leu  Leu Glu Pro 
    1055                 1060                 1065             


Ser Ser  Leu Thr Ala Asn Met  Lys Glu Val Pro Leu  Phe Arg Leu 
    1070                 1075                 1080             


Arg His  Phe Pro Cys Gly Asn  Val Asn Tyr Gly Tyr  Gln Gln Gln 
    1085                 1090                 1095             


Gly Leu  Pro Leu Glu Ala Ala  Thr Ala Pro Gly Ala  Gly His Tyr 
    1100                 1105                 1110             


Glu Asp  Thr Ile Leu Lys Ser  Lys Asn Ser Met Asn  Gln Pro Gly 
    1115                 1120                 1125             


Pro 
    


<210> 89
<211> 3926
<212> DNA
<213> Homo sapiens

<400> 89
ggcggcgcgg cgcggcgctc gcggctgctg cctgggaggg aggccgggca ggcggctgag       60

cggcgcggct ctcaacgtga cggggaagtg gttcgggcgg ccgcggctta ctaccccagg      120

gcgaacggac ggacgacgga ggcgggagcc ggtagccgag ccgggcgacc tagagaacga      180

gcgggtcagg ctcagcgtcg gccactctgt cggtccgctg aatgaagtgc ccgcccctct      240

gagcccggag cccggcgctt tccccgcaag atggacggtt tcgccggcag tctcgatgat      300

agtatttctg ctgcaagtac ttctgatgtt caagatcgcc tgtcagctct tgagtcacga      360

gttcagcaac aagaagatga aatcactgtg ctaaaggcgg ctttggctga tgttttgagg      420

cgtcttgcaa tctctgaaga tcatgtggcc tcagtgaaaa aatcagtctc aagtaaaggc      480

caaccaagcc ctcgagcagt tattcccatg tcctgtataa ccaatggaag tggtgcaaac      540

agaaaaccaa gtcataccag tgctgtctca attgcaggaa aagaaactct ttcatctgct      600

gctaaaagtg gtacagaaaa aaagaaagaa aaaccacaag gacagagaga aaaaaaagag      660

gaatctcatt ctaatgatca aagtccacaa attcgagcat caccttctcc ccagccctct      720

tcacaacctc tccaaataca cagacaaact ccagaaagca agaatgctac tcccaccaaa      780

agcataaaac gaccatcacc agctgaaaag tcacataatt cttgggaaaa ttcagatgat      840

agccgtaata aattgtcgaa aataccttca acacccaaat taataccaaa agttaccaaa      900

actgcagaca agcataaaga tgtcatcatc aaccaagaag gagaatatat taaaatgttt      960

atgcgcggtc ggccaattac catgttcatt ccttccgatg ttgacaacta tgatgacatc     1020

agaacggaac tgcctcctga gaagctcaaa ctggagtggg catatggtta tcgaggaaag     1080

gactgtagag ctaatgttta ccttcttccg accggggaaa tagtttattt cattgcatca     1140

gtagtagtac tatttaatta tgaggagaga actcagcgac actacctggg ccatacagac     1200

tgtgtgaaat gccttgctat acatcctgac aaaattagga ttgcaactgg acagatagct     1260

ggcgtggata aagatggaag gcctctacaa ccccacgtca gagtgtggga ttctgttact     1320

ctatccacac tgcagattat tggacttggc acttttgagc gtggagtagg atgcctggat     1380

ttttcaaaag cagattcagg tgttcattta tgtgttattg atgactccaa tgagcatatg     1440

cttactgtat gggactggca gaagaaagca aaaggagcag aaataaagac aacaaatgaa     1500

gttgttttgg ctgtggagtt tcacccaaca gatgcaaata ccataattac atgcggtaaa     1560

tctcatattt tcttctggac ctggagcggc aattcactaa caagaaaaca gggaattttt     1620

gggaaatatg aaaagccaaa atttgtgcag tgtttagcat tcttggggaa tggagatgtt     1680

cttactggag actcaggtgg agtcatgctt atatggagca aaactactgt agagcccaca     1740

cctgggaaag gacctaaagt gtaccgccgg aagcaccagg agctgcaagc catgcagatg     1800

gagctgcaga gccctgagta caagctgagc aagctccgca cctcgaccat catgaccgac     1860

tacaacccca actactgctt tgctggcaag acctcctcca tcagtgacct gaaggaggtg     1920

ccgcggaaaa acatcaccct cattcggggt ctgggccatg gagcctttgg ggaggtgtat     1980

gaaggccagg tgtccggaat gcccaacgac ccaagccccc tgcaagtggc tgtgaagacg     2040

ctgcctgaag tgtgctctga acaggacgaa ctggatttcc tcatggaagc cctgatcatc     2100

agcaaattca accaccagaa cattgttcgc tgcattgggg tgagcctgca atccctgccc     2160

cggttcatcc tgctggagct catggcgggg ggagacctca agtccttcct ccgagagacc     2220

cgccctcgcc cgagccagcc ctcctccctg gccatgctgg accttctgca cgtggctcgg     2280

gacattgcct gtggctgtca gtatttggag gaaaaccact tcatccaccg agacattgct     2340

gccagaaact gcctcttgac ctgtccaggc cctggaagag tggccaagat tggagacttc     2400

gggatggccc gagacatcta cagggcgagc tactatagaa agggaggctg tgccatgctg     2460

ccagttaagt ggatgccccc agaggccttc atggaaggaa tattcacttc taaaacagac     2520

acatggtcct ttggagtgct gctatgggaa atcttttctc ttggatatat gccatacccc     2580

agcaaaagca accaggaagt tctggagttt gtcaccagtg gaggccggat ggacccaccc     2640

aagaactgcc ctgggcctgt ataccggata atgactcagt gctggcaaca tcagcctgaa     2700

gacaggccca actttgccat cattttggag aggattgaat actgcaccca ggacccggat     2760

gtaatcaaca ccgctttgcc gatagaatat ggtccacttg tggaagagga agagaaagtg     2820

cctgtgaggc ccaaggaccc tgagggggtt cctcctctcc tggtctctca acaggcaaaa     2880

cgggaggagg agcgcagccc agctgcccca ccacctctgc ctaccacctc ctctggcaag     2940

gctgcaaaga aacccacagc tgcagaggtc tctgttcgag tccctagagg gccggccgtg     3000

gaagggggac acgtgaatat ggcattctct cagtccaacc ctccttcgga gttgcacagg     3060

gtccacggat ccagaaacaa gcccaccagc ttgtggaacc caacgtacgg ctcctggttt     3120

acagagaaac ccaccaaaaa gaataatcct atagcaaaga aggagccaca cgagaggggt     3180

aacctggggc tggagggaag ctgtactgtc ccacctaacg ttgcaactgg gagacttccg     3240

ggggcctcac tgctcctaga gccctcttcg ctgactgcca atatgaagga ggtacctctg     3300

ttcaggctac gtcacttccc ttgtgggaat gtcaattacg gctaccagca acagggcttg     3360

cccttagaag ccgctactgc ccctggagct ggtcattacg aggataccat tctgaaaagc     3420

aagaatagca tgaaccagcc tgggccctga gctcggtcac acactcactt ctcttccttg     3480

ggatccctaa gaccgtggag gagagagagg caatcaatgg ctccttcaca aaccagagac     3540

caaatgtcac gttttgtttt gtgccaacct attttgaagt accaccaaaa aagctgtatt     3600

ttgaaaatgc tttagaaagg ttttgagcat gggttcatcc tattctttcg aaagaagaaa     3660

atatcataaa aatgagtgat aaatacaagg cccagatgtg gttgcataag gtttttatgc     3720

atgtttgttg tatacttcct tatgcttctt ttaaattgtg tgtgctctgc ttcaatgtag     3780

tcagaattag ctgcttctat gtttcatagt tggggtcata gatgtttcct tgccttgttg     3840

atgtggacat gagccatttg aggggagagg gaacggaaat aaaggagtta tttgtaatga     3900

aaaaaaaaaa aaaaaaaaaa aaaaaa                                          3926


<210> 90
<211> 1059
<212> PRT
<213> Homo sapiens

<400> 90
Met Asp Gly Phe Ala Gly Ser Leu Asp Asp Ser Ile Ser Ala Ala Ser 
1               5                   10                  15      


Thr Ser Asp Val Gln Asp Arg Leu Ser Ala Leu Glu Ser Arg Val Gln 
            20                  25                  30          


Gln Gln Glu Asp Glu Ile Thr Val Leu Lys Ala Ala Leu Ala Asp Val 
        35                  40                  45              


Leu Arg Arg Leu Ala Ile Ser Glu Asp His Val Ala Ser Val Lys Lys 
    50                  55                  60                  


Ser Val Ser Ser Lys Gly Gln Pro Ser Pro Arg Ala Val Ile Pro Met 
65                  70                  75                  80  


Ser Cys Ile Thr Asn Gly Ser Gly Ala Asn Arg Lys Pro Ser His Thr 
                85                  90                  95      


Ser Ala Val Ser Ile Ala Gly Lys Glu Thr Leu Ser Ser Ala Ala Lys 
            100                 105                 110         


Ser Gly Thr Glu Lys Lys Lys Glu Lys Pro Gln Gly Gln Arg Glu Lys 
        115                 120                 125             


Lys Glu Glu Ser His Ser Asn Asp Gln Ser Pro Gln Ile Arg Ala Ser 
    130                 135                 140                 


Pro Ser Pro Gln Pro Ser Ser Gln Pro Leu Gln Ile His Arg Gln Thr 
145                 150                 155                 160 


Pro Glu Ser Lys Asn Ala Thr Pro Thr Lys Ser Ile Lys Arg Pro Ser 
                165                 170                 175     


Pro Ala Glu Lys Ser His Asn Ser Trp Glu Asn Ser Asp Asp Ser Arg 
            180                 185                 190         


Asn Lys Leu Ser Lys Ile Pro Ser Thr Pro Lys Leu Ile Pro Lys Val 
        195                 200                 205             


Thr Lys Thr Ala Asp Lys His Lys Asp Val Ile Ile Asn Gln Glu Gly 
    210                 215                 220                 


Glu Tyr Ile Lys Met Phe Met Arg Gly Arg Pro Ile Thr Met Phe Ile 
225                 230                 235                 240 


Pro Ser Asp Val Asp Asn Tyr Asp Asp Ile Arg Thr Glu Leu Pro Pro 
                245                 250                 255     


Glu Lys Leu Lys Leu Glu Trp Ala Tyr Gly Tyr Arg Gly Lys Asp Cys 
            260                 265                 270         


Arg Ala Asn Val Tyr Leu Leu Pro Thr Gly Glu Ile Val Tyr Phe Ile 
        275                 280                 285             


Ala Ser Val Val Val Leu Phe Asn Tyr Glu Glu Arg Thr Gln Arg His 
    290                 295                 300                 


Tyr Leu Gly His Thr Asp Cys Val Lys Cys Leu Ala Ile His Pro Asp 
305                 310                 315                 320 


Lys Ile Arg Ile Ala Thr Gly Gln Ile Ala Gly Val Asp Lys Asp Gly 
                325                 330                 335     


Arg Pro Leu Gln Pro His Val Arg Val Trp Asp Ser Val Thr Leu Ser 
            340                 345                 350         


Thr Leu Gln Ile Ile Gly Leu Gly Thr Phe Glu Arg Gly Val Gly Cys 
        355                 360                 365             


Leu Asp Phe Ser Lys Ala Asp Ser Gly Val His Leu Cys Val Ile Asp 
    370                 375                 380                 


Asp Ser Asn Glu His Met Leu Thr Val Trp Asp Trp Gln Lys Lys Ala 
385                 390                 395                 400 


Lys Gly Ala Glu Ile Lys Thr Thr Asn Glu Val Val Leu Ala Val Glu 
                405                 410                 415     


Phe His Pro Thr Asp Ala Asn Thr Ile Ile Thr Cys Gly Lys Ser His 
            420                 425                 430         


Ile Phe Phe Trp Thr Trp Ser Gly Asn Ser Leu Thr Arg Lys Gln Gly 
        435                 440                 445             


Ile Phe Gly Lys Tyr Glu Lys Pro Lys Phe Val Gln Cys Leu Ala Phe 
    450                 455                 460                 


Leu Gly Asn Gly Asp Val Leu Thr Gly Asp Ser Gly Gly Val Met Leu 
465                 470                 475                 480 


Ile Trp Ser Lys Thr Thr Val Glu Pro Thr Pro Gly Lys Gly Pro Lys 
                485                 490                 495     


Val Tyr Arg Arg Lys His Gln Glu Leu Gln Ala Met Gln Met Glu Leu 
            500                 505                 510         


Gln Ser Pro Glu Tyr Lys Leu Ser Lys Leu Arg Thr Ser Thr Ile Met 
        515                 520                 525             


Thr Asp Tyr Asn Pro Asn Tyr Cys Phe Ala Gly Lys Thr Ser Ser Ile 
    530                 535                 540                 


Ser Asp Leu Lys Glu Val Pro Arg Lys Asn Ile Thr Leu Ile Arg Gly 
545                 550                 555                 560 


Leu Gly His Gly Ala Phe Gly Glu Val Tyr Glu Gly Gln Val Ser Gly 
                565                 570                 575     


Met Pro Asn Asp Pro Ser Pro Leu Gln Val Ala Val Lys Thr Leu Pro 
            580                 585                 590         


Glu Val Cys Ser Glu Gln Asp Glu Leu Asp Phe Leu Met Glu Ala Leu 
        595                 600                 605             


Ile Ile Ser Lys Phe Asn His Gln Asn Ile Val Arg Cys Ile Gly Val 
    610                 615                 620                 


Ser Leu Gln Ser Leu Pro Arg Phe Ile Leu Leu Glu Leu Met Ala Gly 
625                 630                 635                 640 


Gly Asp Leu Lys Ser Phe Leu Arg Glu Thr Arg Pro Arg Pro Ser Gln 
                645                 650                 655     


Pro Ser Ser Leu Ala Met Leu Asp Leu Leu His Val Ala Arg Asp Ile 
            660                 665                 670         


Ala Cys Gly Cys Gln Tyr Leu Glu Glu Asn His Phe Ile His Arg Asp 
        675                 680                 685             


Ile Ala Ala Arg Asn Cys Leu Leu Thr Cys Pro Gly Pro Gly Arg Val 
    690                 695                 700                 


Ala Lys Ile Gly Asp Phe Gly Met Ala Arg Asp Ile Tyr Arg Ala Ser 
705                 710                 715                 720 


Tyr Tyr Arg Lys Gly Gly Cys Ala Met Leu Pro Val Lys Trp Met Pro 
                725                 730                 735     


Pro Glu Ala Phe Met Glu Gly Ile Phe Thr Ser Lys Thr Asp Thr Trp 
            740                 745                 750         


Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser Leu Gly Tyr Met Pro 
        755                 760                 765             


Tyr Pro Ser Lys Ser Asn Gln Glu Val Leu Glu Phe Val Thr Ser Gly 
    770                 775                 780                 


Gly Arg Met Asp Pro Pro Lys Asn Cys Pro Gly Pro Val Tyr Arg Ile 
785                 790                 795                 800 


Met Thr Gln Cys Trp Gln His Gln Pro Glu Asp Arg Pro Asn Phe Ala 
                805                 810                 815     


Ile Ile Leu Glu Arg Ile Glu Tyr Cys Thr Gln Asp Pro Asp Val Ile 
            820                 825                 830         


Asn Thr Ala Leu Pro Ile Glu Tyr Gly Pro Leu Val Glu Glu Glu Glu 
        835                 840                 845             


Lys Val Pro Val Arg Pro Lys Asp Pro Glu Gly Val Pro Pro Leu Leu 
    850                 855                 860                 


Val Ser Gln Gln Ala Lys Arg Glu Glu Glu Arg Ser Pro Ala Ala Pro 
865                 870                 875                 880 


Pro Pro Leu Pro Thr Thr Ser Ser Gly Lys Ala Ala Lys Lys Pro Thr 
                885                 890                 895     


Ala Ala Glu Val Ser Val Arg Val Pro Arg Gly Pro Ala Val Glu Gly 
            900                 905                 910         


Gly His Val Asn Met Ala Phe Ser Gln Ser Asn Pro Pro Ser Glu Leu 
        915                 920                 925             


His Arg Val His Gly Ser Arg Asn Lys Pro Thr Ser Leu Trp Asn Pro 
    930                 935                 940                 


Thr Tyr Gly Ser Trp Phe Thr Glu Lys Pro Thr Lys Lys Asn Asn Pro 
945                 950                 955                 960 


Ile Ala Lys Lys Glu Pro His Glu Arg Gly Asn Leu Gly Leu Glu Gly 
                965                 970                 975     


Ser Cys Thr Val Pro Pro Asn Val Ala Thr Gly Arg Leu Pro Gly Ala 
            980                 985                 990         


Ser Leu Leu Leu Glu Pro Ser Ser  Leu Thr Ala Asn Met  Lys Glu Val 
        995                 1000                 1005             


Pro Leu  Phe Arg Leu Arg His  Phe Pro Cys Gly Asn  Val Asn Tyr 
    1010                 1015                 1020             


Gly Tyr  Gln Gln Gln Gly Leu  Pro Leu Glu Ala Ala  Thr Ala Pro 
    1025                 1030                 1035             


Gly Ala  Gly His Tyr Glu Asp  Thr Ile Leu Lys Ser  Lys Asn Ser 
    1040                 1045                 1050             


Met Asn  Gln Pro Gly Pro 
    1055                 


<210> 91
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 91
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 92
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 92
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210> 93
<211> 84
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 93
Phe Val Pro Val Phe Leu Pro Ala Arg Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    50                  55                  60                  


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
65                  70                  75                  80  


His Arg Asn Arg 
                


<210> 94
<211> 40
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 94
Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
1               5                   10                  15      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            20                  25                  30          


Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40  


<210> 95
<211> 42
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 95
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210> 96
<211> 47
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 96
Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
1               5                   10                  15      


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
            20                  25                  30          


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40                  45          


<210> 97
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 97
Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
1               5                   10                  15      


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            20                  25                  30          


Thr Leu Ala Lys Ile 
        35          


<210> 98
<211> 67
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 98
Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val Arg 
65          


<210> 99
<211> 69
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 99
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210> 100
<211> 634
<212> PRT
<213> Mus musculus

<400> 100
Met Gly Gln Arg Gln Ser Ile Leu Lys Arg Cys Pro Glu Gly Ser Phe 
1               5                   10                  15      


Leu Leu Leu Asn Thr Ser Ala Asp Ser Lys His Thr Ile Leu Ser Pro 
            20                  25                  30          


Trp Met Arg Ser Ser Ser Asp His Cys Thr Leu Ala Val Ser Val His 
        35                  40                  45              


Arg His Leu Gln Pro Ser Gly Arg Tyr Val Ala Gln Leu Leu Pro His 
    50                  55                  60                  


Asn Glu Ala Gly Arg Glu Ile Leu Leu Val Pro Thr Pro Gly Lys His 
65                  70                  75                  80  


Gly Trp Thr Val Leu Gln Gly Arg Val Gly Arg Pro Ala Asn Pro Phe 
                85                  90                  95      


Arg Val Ala Leu Glu Tyr Ile Ser Ser Gly Asn Arg Ser Leu Ser Ala 
            100                 105                 110         


Val Asp Phe Phe Ala Leu Lys Asn Cys Ser Glu Gly Thr Ser Pro Gly 
        115                 120                 125             


Ser Lys Met Ala Leu Gln Ser Ser Phe Thr Cys Trp Asn Gly Thr Val 
    130                 135                 140                 


Leu Gln Leu Gly Gln Ala Cys Asp Phe His Gln Asp Cys Ala Gln Gly 
145                 150                 155                 160 


Glu Asp Glu Gly Gln Leu Cys Ser Lys Leu Pro Ala Gly Phe Tyr Cys 
                165                 170                 175     


Asn Phe Glu Asn Gly Phe Cys Gly Trp Thr Gln Ser Pro Leu Ser Pro 
            180                 185                 190         


His Met Pro Arg Trp Gln Val Arg Thr Leu Arg Asp Ala His Ser Gln 
        195                 200                 205             


Gly His Gln Gly Arg Ala Leu Leu Leu Ser Thr Thr Asp Ile Leu Ala 
    210                 215                 220                 


Ser Glu Gly Ala Thr Val Thr Ser Ala Thr Phe Pro Ala Pro Met Lys 
225                 230                 235                 240 


Asn Ser Pro Cys Glu Leu Arg Met Ser Trp Leu Ile Arg Gly Val Leu 
                245                 250                 255     


Arg Gly Asn Val Ser Leu Val Leu Val Glu Asn Lys Thr Gly Lys Glu 
            260                 265                 270         


Gln Ser Arg Thr Val Trp His Val Ala Thr Asp Glu Gly Leu Ser Leu 
        275                 280                 285             


Trp Gln His Thr Val Leu Ser Leu Leu Asp Val Thr Asp Arg Phe Trp 
    290                 295                 300                 


Leu Gln Ile Val Thr Trp Trp Gly Pro Gly Ser Arg Ala Thr Val Gly 
305                 310                 315                 320 


Phe Asp Asn Ile Ser Ile Ser Leu Asp Cys Tyr Leu Thr Ile Ser Gly 
                325                 330                 335     


Glu Glu Lys Met Ser Leu Asn Ser Val Pro Lys Ser Arg Asn Leu Phe 
            340                 345                 350         


Glu Lys Asn Pro Asn Lys Glu Ser Lys Ser Trp Ala Asn Ile Ser Gly 
        355                 360                 365             


Pro Thr Pro Ile Phe Asp Pro Thr Val His Trp Leu Phe Thr Thr Cys 
    370                 375                 380                 


Gly Ala Ser Gly Pro His Gly Pro Thr Gln Ala Gln Cys Asn Asn Ala 
385                 390                 395                 400 


Tyr Gln Asn Ser Asn Leu Ser Val Val Val Gly Ser Glu Gly Pro Leu 
                405                 410                 415     


Lys Gly Val Gln Ile Trp Lys Val Pro Ala Thr Asp Thr Tyr Ser Ile 
            420                 425                 430         


Ser Gly Tyr Gly Ala Ala Gly Gly Lys Gly Gly Lys Asn Thr Met Met 
        435                 440                 445             


Arg Ser His Gly Val Ser Val Leu Gly Ile Phe Asn Leu Glu Lys Gly 
    450                 455                 460                 


Asp Thr Leu Tyr Ile Leu Val Gly Gln Gln Gly Glu Asp Ala Cys Pro 
465                 470                 475                 480 


Arg Ala Asn Gln Leu Ile Gln Lys Val Cys Val Gly Glu Asn Asn Val 
                485                 490                 495     


Ile Glu Glu Glu Ile Arg Val Asn Arg Ser Val His Glu Trp Ala Gly 
            500                 505                 510         


Gly Gly Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Lys Met Lys Asp 
        515                 520                 525             


Gly Val Pro Val Pro Leu Ile Ile Ala Ala Gly Gly Gly Gly Arg Ala 
    530                 535                 540                 


Tyr Gly Ala Lys Thr Glu Thr Phe His Pro Glu Arg Leu Glu Ser Asn 
545                 550                 555                 560 


Ser Ser Val Leu Gly Leu Asn Gly Asn Ser Gly Ala Ala Gly Gly Gly 
                565                 570                 575     


Gly Gly Trp Asn Asp Asn Thr Ser Leu Leu Trp Ala Gly Lys Ser Leu 
            580                 585                 590         


Leu Glu Gly Ala Ala Gly Gly His Ser Cys Pro Gln Ala Met Lys Lys 
        595                 600                 605             


Trp Gly Trp Glu Thr Arg Gly Gly Phe Gly Gly Gly Gly Gly Gly Gly 
    610                 615                 620                 


Ala Pro Gln Val Glu Glu Ala Glu Asp Ile 
625                 630                 


<210> 101
<211> 6240
<212> DNA
<213> Homo sapiens

<400> 101
agatgcgatc cagcggctct gggggcggca gcggtggtag cagctggtac ctcccgccgc       60

ctctgttcgg agggtcgcgg ggcaccgagg tgctttccgg ccgccctctg gtcggccacc      120

caaagccgcg ggcgctgatg atgggtgagg agggggcggc aagatttcgg gcgcccctgc      180

cctgaacgcc ctcagctgct gccgccgggg ccgctccagt gcctgcgaac tctgaggagc      240

cgaggcgccg gtgagagcaa ggacgctgca aacttgcgca gcgcgggggc tgggattcac      300

gcccagaagt tcagcaggca gacagtccga agccttcccg cagcggagag atagcttgag      360

ggtgcgcaag acggcagcct ccgccctcgg ttcccgccca gaccgggcag aagagcttgg      420

aggagccaaa aggaacgcaa aaggcggcca ggacagcgtg cagcagctgg gagccgccgt      480

tctcagcctt aaaagttgca gagattggag gctgccccga gaggggacag accccagctc      540

cgactgcggg gggcaggaga ggacggtacc caactgccac ctcccttcaa ccatagtagt      600

tcctctgtac cgagcgcagc gagctacaga cgggggcgcg gcactcggcg cggagagcgg      660

gaggctcaag gtcccagcca gtgagcccag tgtgcttgag tgtctctgga ctcgcccctg      720

agcttccagg tctgtttcat ttagactcct gctcgcctcc gtgcagttgg gggaaagcaa      780

gagacttgcg cgcacgcaca gtcctctgga gatcaggtgg aaggagccgc tgggtaccaa      840

ggactgttca gagcctcttc ccatctcggg gagagcgaag ggtgaggctg ggcccggaga      900

gcagtgtaaa cggcctcctc cggcgggatg ggagccatcg ggctcctgtg gctcctgccg      960

ctgctgcttt ccacggcagc tgtgggctcc gggatgggga ccggccagcg cgcgggctcc     1020

ccagctgcgg ggccgccgct gcagccccgg gagccactca gctactcgcg cctgcagagg     1080

aagagtctgg cagttgactt cgtggtgccc tcgctcttcc gtgtctacgc ccgggaccta     1140

ctgctgccac catcctcctc ggagctgaag gctggcaggc ccgaggcccg cggctcgcta     1200

gctctggact gcgccccgct gctcaggttg ctggggccgg cgccgggggt ctcctggacc     1260

gccggttcac cagccccggc agaggcccgg acgctgtcca gggtgctgaa gggcggctcc     1320

gtgcgcaagc tccggcgtgc caagcagttg gtgctggagc tgggcgagga ggcgatcttg     1380

gagggttgcg tcgggccccc cggggaggcg gctgtggggc tgctccagtt caatctcagc     1440

gagctgttca gttggtggat tcgccaaggc gaagggcgac tgaggatccg cctgatgccc     1500

gagaagaagg cgtcggaagt gggcagagag ggaaggctgt ccgcggcaat tcgcgcctcc     1560

cagccccgcc ttctcttcca gatcttcggg actggtcata gctccttgga atcaccaaca     1620

aacatgcctt ctccttctcc tgattatttt acatggaatc tcacctggat aatgaaagac     1680

tccttccctt tcctgtctca tcgcagccga tatggtctgg agtgcagctt tgacttcccc     1740

tgtgagctgg agtattcccc tccactgcat gacctcagga accagagctg gtcctggcgc     1800

cgcatcccct ccgaggaggc ctcccagatg gacttgctgg atgggcctgg ggcagagcgt     1860

tctaaggaga tgcccagagg ctcctttctc cttctcaaca cctcagctga ctccaagcac     1920

accatcctga gtccgtggat gaggagcagc agtgagcact gcacactggc cgtctcggtg     1980

cacaggcacc tgcagccctc tggaaggtac attgcccagc tgctgcccca caacgaggct     2040

gcaagagaga tcctcctgat gcccactcca gggaagcatg gttggacagt gctccaggga     2100

agaatcgggc gtccagacaa cccatttcga gtggccctgg aatacatctc cagtggaaac     2160

cgcagcttgt ctgcagtgga cttctttgcc ctgaagaact gcagtgaagg aacatcccca     2220

ggctccaaga tggccctgca gagctccttc acttgttgga atgggacagt cctccagctt     2280

gggcaggcct gtgacttcca ccaggactgt gcccagggag aagatgagag ccagatgtgc     2340

cggaaactgc ctgtgggttt ttactgcaac tttgaagatg gcttctgtgg ctggacccaa     2400

ggcacactgt caccccacac tcctcaatgg caggtcagga ccctaaagga tgcccggttc     2460

caggaccacc aagaccatgc tctattgctc agtaccactg atgtccccgc ttctgaaagt     2520

gctacagtga ccagtgctac gtttcctgca ccgatcaaga gctctccatg tgagctccga     2580

atgtcctggc tcattcgtgg agtcttgagg ggaaacgtgt ccttggtgct agtggagaac     2640

aaaaccggga aggagcaagg caggatggtc tggcatgtcg ccgcctatga aggcttgagc     2700

ctgtggcagt ggatggtgtt gcctctcctc gatgtgtctg acaggttctg gctgcagatg     2760

gtcgcatggt ggggacaagg atccagagcc atcgtggctt ttgacaatat ctccatcagc     2820

ctggactgct acctcaccat tagcggagag gacaagatcc tgcagaatac agcacccaaa     2880

tcaagaaacc tgtttgagag aaacccaaac aaggagctga aacccgggga aaattcacca     2940

agacagaccc ccatctttga ccctacagtt cattggctgt tcaccacatg tggggccagc     3000

gggccccatg gccccaccca ggcacagtgc aacaacgcct accagaactc caacctgagc     3060

gtggaggtgg ggagcgaggg ccccctgaaa ggcatccaga tctggaaggt gccagccacc     3120

gacacctaca gcatctcggg ctacggagct gctggcggga aaggcgggaa gaacaccatg     3180

atgcggtccc acggcgtgtc tgtgctgggc atcttcaacc tggagaagga tgacatgctg     3240

tacatcctgg ttgggcagca gggagaggac gcctgcccca gtacaaacca gttaatccag     3300

aaagtctgca ttggagagaa caatgtgata gaagaagaaa tccgtgtgaa cagaagcgtg     3360

catgagtggg caggaggcgg aggaggaggg ggtggagcca cctacgtatt taagatgaag     3420

gatggagtgc cggtgcccct gatcattgca gccggaggtg gtggcagggc ctacggggcc     3480

aagacagaca cgttccaccc agagagactg gagaataact cctcggttct agggctaaac     3540

ggcaattccg gagccgcagg tggtggaggt ggctggaatg ataacacttc cttgctctgg     3600

gccggaaaat ctttgcagga gggtgccacc ggaggacatt cctgccccca ggccatgaag     3660

aagtgggggt gggagacaag agggggtttc ggagggggtg gaggggggtg ctcctcaggt     3720

ggaggaggcg gaggatatat aggcggcaat gcagcctcaa acaatgaccc cgaaatggat     3780

ggggaagatg gggtttcctt catcagtcca ctgggcatcc tgtacacccc agctttaaaa     3840

gtgatggaag gccacgggga agtgaatatt aagcattatc taaactgcag tcactgtgag     3900

gtagacgaat gtcacatgga ccctgaaagc cacaaggtca tctgcttctg tgaccacggg     3960

acggtgctgg ctgaggatgg cgtctcctgc attgtgtcac ccaccccgga gccacacctg     4020

ccactctcgc tgatcctctc tgtggtgacc tctgccctcg tggccgccct ggtcctggct     4080

ttctccggca tcatgattgt gtaccgccgg aagcaccagg agctgcaagc catgcagatg     4140

gagctgcaga gccctgagta caagctgagc aagctccgca cctcgaccat catgaccgac     4200

tacaacccca actactgctt tgctggcaag acctcctcca tcagtgacct gaaggaggtg     4260

ccgcggaaaa acatcaccct cattcggggt ctgggccatg gcgcctttgg ggaggtgtat     4320

gaaggccagg tgtccggaat gcccaacgac ccaagccccc tgcaagtggc tgtgaagacg     4380

ctgcctgaag tgtgctctga acaggacgaa ctggatttcc tcatggaagc cctgatcatc     4440

agcaaattca accaccagaa cattgttcgc tgcattgggg tgagcctgca atccctgccc     4500

cggttcatcc tgctggagct catggcgggg ggagacctca agtccttcct ccgagagacc     4560

cgccctcgcc cgagccagcc ctcctccctg gccatgctgg accttctgca cgtggctcgg     4620

gacattgcct gtggctgtca gtatttggag gaaaaccact tcatccaccg agacattgct     4680

gccagaaact gcctcttgac ctgtccaggc cctggaagag tggccaagat tggagacttc     4740

gggatggccc gagacatcta cagggcgagc tactatagaa agggaggctg tgccatgctg     4800

ccagttaagt ggatgccccc agaggccttc atggaaggaa tattcacttc taaaacagac     4860

acatggtcct ttggagtgct gctatgggaa atcttttctc ttggatatat gccatacccc     4920

agcaaaagca accaggaagt tctggagttt gtcaccagtg gaggccggat ggacccaccc     4980

aagaactgcc ctgggcctgt ataccggata atgactcagt gctggcaaca tcagcctgaa     5040

gacaggccca actttgccat cattttggag aggattgaat actgcaccca ggacccggat     5100

gtaatcaaca ccgctttgcc gatagaatat ggtccacttg tggaagagga agagaaagtg     5160

cctgtgaggc ccaaggaccc tgagggggtt cctcctctcc tggtctctca acaggcaaaa     5220

cgggaggagg agcgcagccc agctgcccca ccacctctgc ctaccacctc ctctggcaag     5280

gctgcaaaga aacccacagc tgcagagatc tctgttcgag tccctagagg gccggccgtg     5340

gaagggggac acgtgaatat ggcattctct cagtccaacc ctccttcgga gttgcacaag     5400

gtccacggat ccagaaacaa gcccaccagc ttgtggaacc caacgtacgg ctcctggttt     5460

acagagaaac ccaccaaaaa gaataatcct atagcaaaga aggagccaca cgacaggggt     5520

aacctggggc tggagggaag ctgtactgtc ccacctaacg ttgcaactgg gagacttccg     5580

ggggcctcac tgctcctaga gccctcttcg ctgactgcca atatgaagga ggtacctctg     5640

ttcaggctac gtcacttccc ttgtgggaat gtcaattacg gctaccagca acagggcttg     5700

cccttagaag ccgctactgc ccctggagct ggtcattacg aggataccat tctgaaaagc     5760

aagaatagca tgaaccagcc tgggccctga gctcggtcgc acactcactt ctcttccttg     5820

ggatccctaa gaccgtggag gagagagagg caatggctcc ttcacaaacc agagaccaaa     5880

tgtcacgttt tgttttgtgc caacctattt tgaagtacca ccaaaaaagc tgtattttga     5940

aaatgcttta gaaaggtttt gagcatgggt tcatcctatt ctttcgaaag aagaaaatat     6000

cataaaaatg agtgataaat acaaggccca gatgtggttg cataaggttt ttatgcatgt     6060

ttgttgtata cttccttatg cttctttcaa attgtgtgtg ctctgcttca atgtagtcag     6120

aattagctgc ttctatgttt catagttggg gtcatagatg tttccttgcc ttgttgatgt     6180

ggacatgagc catttgaggg gagagggaac ggaaataaag gagttatttg taatgactaa     6240


<210> 102
<211> 5918
<212> DNA
<213> Mus musculus

<400> 102
gtgttcacgc ccagaagttc agcgggcagg gtgatcgatc cgaagacttc ctgcagcgga       60

ggtcacttga gggggcgcta gaaagcagcc ccctccggtg gtccttgcct agacctggga      120

aggagcgcag aggaggtgac aggagcggag gacgtgggca agacagtgac cgactcggag      180

ccacggttca cagcctggaa agttgcagaa gattggaagc taagaggaga gctctggtcg      240

ccgagggctc cttgaacggt acctaattgc cacctccctg gtccctgagc aaaggcctct      300

acaaatgggg cgcagcacgg cgagaggcgc aggatccagc tgttgagccc agggtgtctc      360

actgtctccg aactaccccc tgactttgtc ttccgttttg ctgagaaccc ttctcgcctc      420

cttgtagctt gggaaaagca agggcgctct atagtgtaca cacagtccct gagatctagt      480

ggaaggagcc attcaggacc aaggactatt tggagccctt tcctgtttgg gggagagtga      540

agggcgaggc tggaccagca agggaaggga gactagtgta aactcgccct ccagcgggat      600

gggagctgct gggttcctgt ggctgctgcc tccactgctt ttggcagcag cctcgtactc      660

cggagctgca accgatcagc gcgcgggttc cccagcctca gggcctcctc tgcagccccg      720

ggagccgctc agttattcgc gcctgcagag gaagagtctg gcagtggact tcgttgtacc      780

ctcgctcttc cgcgtctatg cccgagacct gctgctaccg cagccacggt ccccctcgga      840

gcccgaggct ggcgggctgg aggcgcgggg atcactggcc ctggattgtg agcctctgct      900

caggctgctg gggccactgc ctggaatctc ctgggcagat ggagccagtt ctcctagtcc      960

cgaggcgggt ccgacgctgt ccagggtgct gaagggaggc tcggtgcgca agctcaggcg     1020

tgccaaacag ctggtgctgg agctgggcga ggagacgatt cttgaaggct gtattggtcc     1080

cccagaggag gtagcggctg tggggatact ccagttcaac ctcagcgagc tgttcagctg     1140

gtggattctc cacggcgaag ggaggctgag gatccgcctg atgcctgaga agaaggcatc     1200

ggaagtgggc agggagggaa ggctatccag tgcgatccga gcctcccagc cccgccttct     1260

cttccagatc ttcgggacgg gacacagctc catggagtca ccctcagaaa cgccttctcc     1320

tcctggtacc ttcatgtgga atctgacctg gacgatgaaa gactccttcc ctttcctttc     1380

ccaccgcagt cgatatggtc tggagtgcag ctttgacttc ccctgtgagc tggaatattc     1440

tcctcccctg cacaaccacg ggaatcagag ctggtcctgg cgccatgtgc cctccgagga     1500

ggcctcgagg atgaacttgc tggatgggcc agaggcagag cattctcaag agatgcccag     1560

aggctccttc ctcctcctga acacctctgc agattccaag cataccattc tgagcccatg     1620

gatgaggagc agtagtgatc actgcacact ggctgtctcc gtgcacagac atctacagcc     1680

ttcggggaga tatgttgccc agctcctacc ccacaacgaa gctggaagag agattctttt     1740

ggtgcccacc ccagggaagc atggctggac agtgctgcag gggagagtcg ggcgcccagc     1800

aaacccattt cgagtggctc tggaatacat ctccagtggc aaccggagct tgtcggcggt     1860

ggatttcttt gccctgaaga actgcagtga agggacatcc ccaggctcca agatggcatt     1920

gcagagttcc ttcacttgtt ggaatgggac cgtcctccag ctcgggcaag cctgtgattt     1980

ccaccaggac tgtgcccaag gagaagatga gggccagctg tgcagtaaac ttcctgctgg     2040

attttactgt aactttgaaa atggcttctg tggctggacc caaagtccac tctcacccca     2100

tatgccccgg tggcaagtga ggaccctaag agatgcccat tcccagggcc accaaggccg     2160

tgccctgttg ctcagcacca ctgacatcct cgcttctgaa ggtgcaacag tgaccagtgc     2220

caccttccct gcaccaatga aaaattctcc ttgtgagctc cgcatgtcct ggctcatccg     2280

cggggttttg agaggaaacg tatctctggt gctggtggag aacaaaaccg gaaaggagca     2340

aagccggact gtctggcatg tcgccactga cgaaggctta agcctgtggc agcatacagt     2400

gctgtccctc ctcgatgtga ctgacaggtt ctggctgcag atagtcacat ggtggggtcc     2460

aggatccagg gcaaccgtgg gatttgacaa catttccatc agcctcgact gctaccttac     2520

catcagtgga gaggagaaaa tgtccctgaa ttcagtaccc aaatctagaa atctgtttga     2580

gaaaaaccca aacaaggagt caaaatcctg ggcaaacata tcaggaccaa ctcccatctt     2640

cgaccctaca gttcactggc tgttcaccac gtgtggggcc agtggacctc atggccccac     2700

ccaggcacag tgcaacaacg cctaccagaa ttccaacttg agcgtggtgg tgggaagtga     2760

agggcccttg aagggagtcc agatttggaa agtgccagct actgacacct acagtatctc     2820

gggctacgga gcagctggcg ggaaaggtgg gaaaaacacc atgatgcggt cccatggcgt     2880

gtctgtcctg ggcatcttca atctggagaa aggtgacaca ctctacatcc ttgtcggtca     2940

gcaaggggag gatgcctgtc ccagggcaaa ccaactaatc cagaaagtct gtgtgggtga     3000

gaacaatgtc atagaagaag agatccgagt gaacagaagc gtgcacgagt gggcaggagg     3060

aggaggaggt gggggtggag ccacctacgt gtttaagatg aaagatggcg tgcctgtacc     3120

cctgatcatt gcagctggtg gtggtggcag ggcctatggg gccaagacag aaacgttcca     3180

cccagagaga ctggagagta actcctcggt tctagggctg aacggcaatt ccggagccgc     3240

aggtggtgga ggcggctgga atgataacac ttccttgctc tgggccggaa agtctttgct     3300

ggagggtgcc gccggaggac attcctgccc ccaggccatg aagaagtggg ggtgggagac     3360

aagagggggt ttcggagggg gtggaggggg gtgctcctca ggtggaggag gcggaggata     3420

tataggtggc aacgcagcat caaacaatga ccccgaaatg gatggggaag atggggtttc     3480

cttcatcagt ccattgggta tcctgtacac cccggcctta aaagtgatgg agggccacgg     3540

ggaagtgaat atcaagcatt atctaaactg cagtcactgc gaggtagacg aatgtcacat     3600

ggaccccgag agccacaaag tcatctgctt ctgtgatcat gggaccgtgc tggctgatga     3660

tggtgtctcc tgcattgtgt cacccacccc ggagccccac ctgccgctct cattgatcct     3720

ctccgtcgtg acctctgccc tggtggctgc ccttgttctg gcattctccg gcatcatgat     3780

tgtgtaccgt cggaagcacc aggagttgca ggctatgcag atggaactgc agagccccga     3840

gtataagctg agcaagctac ggacctcgac catcatgacc gactacaacc ccaactactg     3900

cttcgctggc aagacttcct ccatcagtga cctgaaagaa gtgccacgga aaaacatcac     3960

actcatccgg ggcctaggcc atggcgcatt tggggaggtg tatgaaggcc aggtgtctgg     4020

aatgcccaat gacccaagcc ctctacaagt ggctgtaaag acgctgccag aagtgtgttc     4080

agaacaagat gagctggact ttctcatgga agctctgatc atcagcaaat tcaaccacca     4140

gaatattgtt cgctgcatcg gggtgagtct acaagccctg ccccgcttca tcctgctgga     4200

actcatggct ggcggagacc tcaagtcctt cctcagggag acacgccctc gcccgaacca     4260

acccacctcc ctggccatgc tggaccttct gcatgtggct cgggacattg cctgtggctg     4320

tcagtaccta gaggagaatc actttatcca ccgggatatt gctgctagaa actgtctgtt     4380

gacctgccca ggagctggaa gaatagcaaa gattggagac tttgggatgg cccgagatat     4440

ctacagggcc agctactacc gaaagggagg ctgcgccatg ctgccggtca agtggatgcc     4500

ccctgaagcc ttcatggaag ggatatttac ctctaaaaca gacacatggt cttttggagt     4560

gttgctatgg gaaatatttt ctcttggata tatgccgtac cccagcaaga gcaaccagga     4620

agttctggag tttgtcacca gcggaggacg gatggacccg cctaagaact gccccgggcc     4680

tgtataccgg ataatgacgc agtgctggca gcatcagcct gaagacagac ccaacttcgc     4740

catcattttg gagaggatcg aatactgcac ccaggacccc gatgtgatca acacagctct     4800

gcccatcgaa tacggtccag tagtagaaga ggaggagaaa gtgcccatgc gccccaaaga     4860

ccccgagggg atgccacctt tgctggtgtc tccccagcct gcgaagcacg aggaggcgtc     4920

cgcagctccc cagcccgcag ccctgacggc accaggccca tcggtgaaga agcccccggg     4980

tgcgggtgcg ggcgcgggcg cgggtgcggg tgccggcccg gtgccccgag gtgcggccga     5040

tcggggccac gtgaacatgg ctttctctca gcccaaccct cccccggagc tgcacaaagg     5100

cccgggatcc agaaacaagc cgaccagcct gtggaacccc acctacggct cgtggttcac     5160

cgagaagcct gccaaaaaga cccatcctcc gccaggcgcc gagccgcagg cgcgggcagg     5220

agcggccgag ggtggctgga ccgggccggg cgcggggccc cgcagagccg aggcagcgct     5280

gctgctagag ccatcggcgc tgagcgccac catgaaggag gtgccgctgt tcaggctgcg     5340

ccacttcccc tgcggcaatg tcaactatgg ttaccagcaa cagggtctcc ccttggaagc     5400

cacagccgcg ccaggggaca ccatgctgaa aagcaagaat aaggtcaccc agccggggcc     5460

ctgagccctg tactccacta gcttctcctc ctggcggagc cggagcccac ccagagggag     5520

atggacagga tggctccacc acaaacccaa gaccaaaact ttcatttttg tgccaacttg     5580

ttttgaagtg ccacatttta aaaaaaggaa acttgtgttt ttaagatgtg ttagaaggtt     5640

ttttgagcat gggttcatct atcctctcaa aagaagaaaa tgccattctt taaaaaagaa     5700

aaaaaagcaa tcagtgcaag gcccagattg gttgcgccaa gttttcgtgc atggtctgct     5760

gtacagtccc ctaaggcttc tttccgattt ttgtgtgcgc tctgcttccg cgtagtcaga     5820

aatagctgct tccatgtctc atagggggag tcctaggtgt ttcctttgcc ttatgaatat     5880

gaaccactcg aggggcgggc gagggaacag aaataaag                             5918


<210> 103
<211> 2043
<212> DNA
<213> Homo sapiens

<400> 103
atggaagatt cgatggacat ggacatgagc cccctgaggc cccagaacta tcttttcggt       60

tgtgaactaa aggccgacaa agattatcac tttaaggtgg ataatgatga aaatgagcac      120

cagttatctt taagaacggt cagtttaggg gctggtgcaa aggatgagtt gcacattgtt      180

gaagcagagg caatgaatta cgaaggcagt ccaattaaag taacactggc aactttgaaa      240

atgtctgtac agccaacggt ttcccttggg ggctttgaaa taacaccacc agtggtctta      300

aggttgaagt gtggttcagg gccagtgcat attagtggac agcacttagt agtgtaccgc      360

cggaagcacc aggagctgca agccatgcag atggagctgc agagccctga gtacaagctg      420

agcaagctcc gcacctcgac catcatgacc gactacaacc ccaactactg ctttgctggc      480

aagacctcct ccatcagtga cctgaaggag gtgccgcgga aaaacatcac cctcattcgg      540

ggtctgggcc atggcgcctt tggggaggtg tatgaaggcc aggtgtccgg aatgcccaac      600

gacccaagcc ccctgcaagt ggctgtgaag acgctgcctg aagtgtgctc tgaacaggac      660

gaactggatt tcctcatgga agccctgatc atcagcaaat tcaaccacca gaacattgtt      720

cgctgcattg gggtgagcct gcaatccctg ccccggttca tcctgctgga gctcatggcg      780

gggggagacc tcaagtcctt cctccgagag acccgccctc gcccgagcca gccctcctcc      840

ctggccatgc tggaccttct gcacgtggct cgggacattg cctgtggctg tcagtatttg      900

gaggaaaacc acttcatcca ccgagacatt gctgccagaa actgcctctt gacctgtcca      960

ggccctggaa gagtggccaa gattggagac ttcgggatgg cccgagacat ctacagggcg     1020

agctactata gaaagggagg ctgtgccatg ctgccagtta agtggatgcc cccagaggcc     1080

ttcatggaag gaatattcac ttctaaaaca gacacatggt cctttggagt gctgctatgg     1140

gaaatctttt ctcttggata tatgccatac cccagcaaaa gcaaccagga agttctggag     1200

tttgtcacca gtggaggccg gatggaccca cccaagaact gccctgggcc tgtataccgg     1260

ataatgactc agtgctggca acatcagcct gaagacaggc ccaactttgc catcattttg     1320

gagaggattg aatactgcac ccaggacccg gatgtaatca acaccgcttt gccgatagaa     1380

tatggtccac ttgtggaaga ggaagagaaa gtgcctgtga ggcccaagga ccctgagggg     1440

gttcctcctc tcctggtctc tcaacaggca aaacgggagg aggagcgcag cccagctgcc     1500

ccaccacctc tgcctaccac ctcctctggc aaggctgcaa agaaacccac agctgcagag     1560

gtctctgttc gagtccctag agggccggcc gtggaagggg gacacgtgaa tatggcattc     1620

tctcagtcca accctccttc ggagttgcac aaggtccacg gatccagaaa caagcccacc     1680

agcttgtgga acccaacgta cggctcctgg tttacagaga aacccaccaa aaagaataat     1740

cctatagcaa agaaggagcc acacgacagg ggtaacctgg ggctggaggg aagctgtact     1800

gtcccaccta acgttgcaac tgggagactt ccgggggcct cactgctcct agagccctct     1860

tcgctgactg ccaatatgaa ggaggtacct ctgttcaggc tacgtcactt cccttgtggg     1920

aatgtcaatt acggctacca gcaacagggc ttgcccttag aagccgctac tgcccctgga     1980

gctggtcatt acgaggatac cattctgaaa agcaagaata gcatgaacca gcctgggccc     2040

tga                                                                   2043


<210> 104
<211> 1129
<212> PRT
<213> Homo sapiens

<400> 104
Met Asp Gly Phe Ala Gly Ser Leu Asp Asp Ser Ile Ser Ala Ala Ser 
1               5                   10                  15      


Thr Ser Asp Val Gln Asp Arg Leu Ser Ala Leu Glu Ser Arg Val Gln 
            20                  25                  30          


Gln Gln Glu Asp Glu Ile Thr Val Leu Lys Ala Ala Leu Ala Asp Val 
        35                  40                  45              


Leu Arg Arg Leu Ala Ile Ser Glu Asp His Val Ala Ser Val Lys Lys 
    50                  55                  60                  


Ser Val Ser Ser Lys Gly Gln Pro Ser Pro Arg Ala Val Ile Pro Met 
65                  70                  75                  80  


Ser Cys Ile Thr Asn Gly Ser Gly Ala Asn Arg Lys Pro Ser His Thr 
                85                  90                  95      


Ser Ala Val Ser Ile Ala Gly Lys Glu Thr Leu Ser Ser Ala Ala Lys 
            100                 105                 110         


Ser Gly Thr Glu Lys Lys Lys Glu Lys Pro Gln Gly Gln Arg Glu Lys 
        115                 120                 125             


Lys Glu Glu Ser His Ser Asn Asp Gln Ser Pro Gln Ile Arg Ala Ser 
    130                 135                 140                 


Pro Ser Pro Gln Pro Ser Ser Gln Pro Leu Gln Ile His Arg Gln Thr 
145                 150                 155                 160 


Pro Glu Ser Lys Asn Ala Thr Pro Thr Lys Ser Ile Lys Arg Pro Ser 
                165                 170                 175     


Pro Ala Glu Lys Ser His Asn Ser Trp Glu Asn Ser Asp Asp Ser Arg 
            180                 185                 190         


Asn Lys Leu Ser Lys Ile Pro Ser Thr Pro Lys Leu Ile Pro Lys Val 
        195                 200                 205             


Thr Lys Thr Ala Asp Lys His Lys Asp Val Ile Ile Asn Gln Glu Gly 
    210                 215                 220                 


Glu Tyr Ile Lys Met Phe Met Arg Gly Arg Pro Ile Thr Met Phe Ile 
225                 230                 235                 240 


Pro Ser Asp Val Asp Asn Tyr Asp Asp Ile Arg Thr Glu Leu Pro Pro 
                245                 250                 255     


Glu Lys Leu Lys Leu Glu Trp Ala Tyr Gly Tyr Arg Gly Lys Asp Cys 
            260                 265                 270         


Arg Ala Asn Val Tyr Leu Leu Pro Thr Gly Glu Ile Val Tyr Phe Ile 
        275                 280                 285             


Ala Ser Val Val Val Leu Phe Asn Tyr Glu Glu Arg Thr Gln Arg His 
    290                 295                 300                 


Tyr Leu Gly His Thr Asp Cys Val Lys Cys Leu Ala Ile His Pro Asp 
305                 310                 315                 320 


Lys Ile Arg Ile Ala Thr Gly Gln Ile Ala Gly Val Asp Lys Asp Gly 
                325                 330                 335     


Arg Pro Leu Gln Pro His Val Arg Val Trp Asp Ser Val Thr Leu Ser 
            340                 345                 350         


Thr Leu Gln Ile Ile Gly Leu Gly Thr Phe Glu Arg Gly Val Gly Cys 
        355                 360                 365             


Leu Asp Phe Ser Lys Ala Asp Ser Gly Val His Leu Cys Val Ile Asp 
    370                 375                 380                 


Asp Ser Asn Glu His Met Leu Thr Val Trp Asp Trp Gln Arg Lys Ala 
385                 390                 395                 400 


Lys Gly Ala Glu Ile Lys Thr Thr Asn Glu Val Val Leu Ala Val Glu 
                405                 410                 415     


Phe His Pro Thr Asp Ala Asn Thr Ile Ile Thr Cys Gly Lys Ser His 
            420                 425                 430         


Ile Phe Phe Trp Thr Trp Ser Gly Asn Ser Leu Thr Arg Lys Gln Gly 
        435                 440                 445             


Ile Phe Gly Lys Tyr Glu Lys Pro Lys Phe Val Gln Cys Leu Ala Phe 
    450                 455                 460                 


Leu Gly Asn Gly Asp Val Leu Thr Gly Asp Ser Gly Gly Val Met Leu 
465                 470                 475                 480 


Ile Trp Ser Lys Thr Thr Val Glu Pro Thr Pro Gly Lys Gly Pro Lys 
                485                 490                 495     


Gly Val Tyr Gln Ile Ser Lys Gln Ile Lys Ala His Asp Gly Ser Val 
            500                 505                 510         


Phe Thr Leu Cys Gln Met Arg Asn Gly Met Leu Leu Thr Gly Gly Gly 
        515                 520                 525             


Lys Asp Arg Lys Ile Ile Leu Trp Asp His Asp Leu Asn Pro Glu Arg 
    530                 535                 540                 


Glu Ile Glu Phe Ser Ala Ser Arg Ala Arg Leu Pro Gly His Val Ala 
545                 550                 555                 560 


Ala Asp His Pro Pro Ala Val Tyr Arg Arg Lys His Gln Glu Leu Gln 
                565                 570                 575     


Ala Met Gln Met Glu Leu Gln Ser Pro Glu Tyr Lys Leu Ser Lys Leu 
            580                 585                 590         


Arg Thr Ser Thr Ile Met Thr Asp Tyr Asn Pro Asn Tyr Cys Phe Ala 
        595                 600                 605             


Gly Lys Thr Ser Ser Ile Ser Asp Leu Lys Glu Val Pro Arg Lys Asn 
    610                 615                 620                 


Ile Thr Leu Ile Arg Gly Leu Gly His Gly Ala Phe Gly Glu Val Tyr 
625                 630                 635                 640 


Glu Gly Gln Val Ser Gly Met Pro Asn Asp Pro Ser Pro Leu Gln Val 
                645                 650                 655     


Ala Val Lys Thr Leu Pro Glu Val Cys Ser Glu Gln Asp Glu Leu Asp 
            660                 665                 670         


Phe Leu Met Glu Ala Leu Ile Ile Ser Lys Phe Asn His Gln Asn Ile 
        675                 680                 685             


Val Arg Cys Ile Gly Val Ser Leu Gln Ser Leu Pro Arg Phe Ile Leu 
    690                 695                 700                 


Leu Glu Leu Met Ala Gly Gly Asp Leu Lys Ser Phe Leu Arg Glu Thr 
705                 710                 715                 720 


Arg Pro Arg Pro Ser Gln Pro Ser Ser Leu Ala Met Leu Asp Leu Leu 
                725                 730                 735     


His Val Ala Arg Asp Ile Ala Cys Gly Cys Gln Tyr Leu Glu Glu Asn 
            740                 745                 750         


His Phe Ile His Arg Asp Ile Ala Ala Arg Asn Cys Leu Leu Thr Cys 
        755                 760                 765             


Pro Gly Pro Gly Arg Val Ala Lys Ile Gly Asp Phe Gly Met Ala Arg 
    770                 775                 780                 


Asp Ile Tyr Arg Ala Ser Tyr Tyr Arg Lys Gly Gly Cys Ala Met Leu 
785                 790                 795                 800 


Pro Val Lys Trp Met Pro Pro Glu Ala Phe Met Glu Gly Ile Phe Thr 
                805                 810                 815     


Ser Lys Thr Asp Thr Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe 
            820                 825                 830         


Ser Leu Gly Tyr Met Pro Tyr Pro Ser Lys Ser Asn Gln Glu Val Leu 
        835                 840                 845             


Glu Phe Val Thr Ser Gly Gly Arg Met Asp Pro Pro Lys Asn Cys Pro 
    850                 855                 860                 


Gly Pro Val Tyr Arg Ile Met Thr Gln Cys Trp Gln His Gln Pro Glu 
865                 870                 875                 880 


Asp Arg Pro Asn Phe Ala Ile Ile Leu Glu Arg Ile Glu Tyr Cys Thr 
                885                 890                 895     


Gln Asp Pro Asp Val Ile Asn Thr Ala Leu Pro Ile Glu Tyr Gly Pro 
            900                 905                 910         


Leu Val Glu Glu Glu Glu Lys Val Pro Val Arg Pro Lys Asp Pro Glu 
        915                 920                 925             


Gly Val Pro Pro Leu Leu Val Ser Gln Gln Ala Lys Arg Glu Glu Glu 
    930                 935                 940                 


Arg Ser Pro Ala Ala Pro Pro Pro Leu Pro Thr Thr Ser Ser Gly Lys 
945                 950                 955                 960 


Ala Ala Lys Lys Pro Thr Ala Ala Glu Ile Ser Val Arg Val Pro Arg 
                965                 970                 975     


Gly Pro Ala Val Glu Gly Gly His Val Asn Met Ala Phe Ser Gln Ser 
            980                 985                 990         


Asn Pro Pro Ser Glu Leu His Lys  Val His Gly Ser Arg  Asn Lys Pro 
        995                 1000                 1005             


Thr Ser  Leu Trp Asn Pro Thr  Tyr Gly Ser Trp Phe  Thr Glu Lys 
    1010                 1015                 1020             


Pro Thr  Lys Lys Asn Asn Pro  Ile Ala Lys Lys Glu  Pro His Asp 
    1025                 1030                 1035             


Arg Gly  Asn Leu Gly Leu Glu  Gly Ser Cys Thr Val  Pro Pro Asn 
    1040                 1045                 1050             


Val Ala  Thr Gly Arg Leu Pro  Gly Ala Ser Leu Leu  Leu Glu Pro 
    1055                 1060                 1065             


Ser Ser  Leu Thr Ala Asn Met  Lys Glu Val Pro Leu  Phe Arg Leu 
    1070                 1075                 1080             


Arg His  Phe Pro Cys Gly Asn  Val Asn Tyr Gly Tyr  Gln Gln Gln 
    1085                 1090                 1095             


Gly Leu  Pro Leu Glu Ala Ala  Thr Ala Pro Gly Ala  Gly His Tyr 
    1100                 1105                 1110             


Glu Asp  Thr Ile Leu Lys Ser  Lys Asn Ser Met Asn  Gln Pro Gly 
    1115                 1120                 1125             


Pro 
    


<210> 105
<211> 1059
<212> PRT
<213> Homo sapiens

<400> 105
Met Asp Gly Phe Ala Gly Ser Leu Asp Asp Ser Ile Ser Ala Ala Ser 
1               5                   10                  15      


Thr Ser Asp Val Gln Asp Arg Leu Ser Ala Leu Glu Ser Arg Val Gln 
            20                  25                  30          


Gln Gln Glu Asp Glu Ile Thr Val Leu Lys Ala Ala Leu Ala Asp Val 
        35                  40                  45              


Leu Arg Arg Leu Ala Ile Ser Glu Asp His Val Ala Ser Val Lys Lys 
    50                  55                  60                  


Ser Val Ser Ser Lys Gly Gln Pro Ser Pro Arg Ala Val Ile Pro Met 
65                  70                  75                  80  


Ser Cys Ile Thr Asn Gly Ser Gly Ala Asn Arg Lys Pro Ser His Thr 
                85                  90                  95      


Ser Ala Val Ser Ile Ala Gly Lys Glu Thr Leu Ser Ser Ala Ala Lys 
            100                 105                 110         


Ser Gly Thr Glu Lys Lys Lys Glu Lys Pro Gln Gly Gln Arg Glu Lys 
        115                 120                 125             


Lys Glu Glu Ser His Ser Asn Asp Gln Ser Pro Gln Ile Arg Ala Ser 
    130                 135                 140                 


Pro Ser Pro Gln Pro Ser Ser Gln Pro Leu Gln Ile His Arg Gln Thr 
145                 150                 155                 160 


Pro Glu Ser Lys Asn Ala Thr Pro Thr Lys Ser Ile Lys Arg Pro Ser 
                165                 170                 175     


Pro Ala Glu Lys Ser His Asn Ser Trp Glu Asn Ser Asp Asp Ser Arg 
            180                 185                 190         


Asn Lys Leu Ser Lys Ile Pro Ser Thr Pro Lys Leu Ile Pro Lys Val 
        195                 200                 205             


Thr Lys Thr Ala Asp Lys His Lys Asp Val Ile Ile Asn Gln Glu Gly 
    210                 215                 220                 


Glu Tyr Ile Lys Met Phe Met Arg Gly Arg Pro Ile Thr Met Phe Ile 
225                 230                 235                 240 


Pro Ser Asp Val Asp Asn Tyr Asp Asp Ile Arg Thr Glu Leu Pro Pro 
                245                 250                 255     


Glu Lys Leu Lys Leu Glu Trp Ala Tyr Gly Tyr Arg Gly Lys Asp Cys 
            260                 265                 270         


Arg Ala Asn Val Tyr Leu Leu Pro Thr Gly Glu Ile Val Tyr Phe Ile 
        275                 280                 285             


Ala Ser Val Val Val Leu Phe Asn Tyr Glu Glu Arg Thr Gln Arg His 
    290                 295                 300                 


Tyr Leu Gly His Thr Asp Cys Val Lys Cys Leu Ala Ile His Pro Asp 
305                 310                 315                 320 


Lys Ile Arg Ile Ala Thr Gly Gln Ile Ala Gly Val Asp Lys Asp Gly 
                325                 330                 335     


Arg Pro Leu Gln Pro His Val Arg Val Trp Asp Ser Val Thr Leu Ser 
            340                 345                 350         


Thr Leu Gln Ile Ile Gly Leu Gly Thr Phe Glu Arg Gly Val Gly Cys 
        355                 360                 365             


Leu Asp Phe Ser Lys Ala Asp Ser Gly Val His Leu Cys Val Ile Asp 
    370                 375                 380                 


Asp Ser Asn Glu His Met Leu Thr Val Trp Asp Trp Gln Lys Lys Ala 
385                 390                 395                 400 


Lys Gly Ala Glu Ile Lys Thr Thr Asn Glu Val Val Leu Ala Val Glu 
                405                 410                 415     


Phe His Pro Thr Asp Ala Asn Thr Ile Ile Thr Cys Gly Lys Ser His 
            420                 425                 430         


Ile Phe Phe Trp Thr Trp Ser Gly Asn Ser Leu Thr Arg Lys Gln Gly 
        435                 440                 445             


Ile Phe Gly Lys Tyr Glu Lys Pro Lys Phe Val Gln Cys Leu Ala Phe 
    450                 455                 460                 


Leu Gly Asn Gly Asp Val Leu Thr Gly Asp Ser Gly Gly Val Met Leu 
465                 470                 475                 480 


Ile Trp Ser Lys Thr Thr Val Glu Pro Thr Pro Gly Lys Gly Pro Lys 
                485                 490                 495     


Val Tyr Arg Arg Lys His Gln Glu Leu Gln Ala Met Gln Met Glu Leu 
            500                 505                 510         


Gln Ser Pro Glu Tyr Lys Leu Ser Lys Leu Arg Thr Ser Thr Ile Met 
        515                 520                 525             


Thr Asp Tyr Asn Pro Asn Tyr Cys Phe Ala Gly Lys Thr Ser Ser Ile 
    530                 535                 540                 


Ser Asp Leu Lys Glu Val Pro Arg Lys Asn Ile Thr Leu Ile Arg Gly 
545                 550                 555                 560 


Leu Gly His Gly Ala Phe Gly Glu Val Tyr Glu Gly Gln Val Ser Gly 
                565                 570                 575     


Met Pro Asn Asp Pro Ser Pro Leu Gln Val Ala Val Lys Thr Leu Pro 
            580                 585                 590         


Glu Val Cys Ser Glu Gln Asp Glu Leu Asp Phe Leu Met Glu Ala Leu 
        595                 600                 605             


Ile Ile Ser Lys Phe Asn His Gln Asn Ile Val Arg Cys Ile Gly Val 
    610                 615                 620                 


Ser Leu Gln Ser Leu Pro Arg Phe Ile Leu Leu Glu Leu Met Ala Gly 
625                 630                 635                 640 


Gly Asp Leu Lys Ser Phe Leu Arg Glu Thr Arg Pro Arg Pro Ser Gln 
                645                 650                 655     


Pro Ser Ser Leu Ala Met Leu Asp Leu Leu His Val Ala Arg Asp Ile 
            660                 665                 670         


Ala Cys Gly Cys Gln Tyr Leu Glu Glu Asn His Phe Ile His Arg Asp 
        675                 680                 685             


Ile Ala Ala Arg Asn Cys Leu Leu Thr Cys Pro Gly Pro Gly Arg Val 
    690                 695                 700                 


Ala Lys Ile Gly Asp Phe Gly Met Ala Arg Asp Ile Tyr Arg Ala Ser 
705                 710                 715                 720 


Tyr Tyr Arg Lys Gly Gly Cys Ala Met Leu Pro Val Lys Trp Met Pro 
                725                 730                 735     


Pro Glu Ala Phe Met Glu Gly Ile Phe Thr Ser Lys Thr Asp Thr Trp 
            740                 745                 750         


Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser Leu Gly Tyr Met Pro 
        755                 760                 765             


Tyr Pro Ser Lys Ser Asn Gln Glu Val Leu Glu Phe Val Thr Ser Gly 
    770                 775                 780                 


Gly Arg Met Asp Pro Pro Lys Asn Cys Pro Gly Pro Val Tyr Arg Ile 
785                 790                 795                 800 


Met Thr Gln Cys Trp Gln His Gln Pro Glu Asp Arg Pro Asn Phe Ala 
                805                 810                 815     


Ile Ile Leu Glu Arg Ile Glu Tyr Cys Thr Gln Asp Pro Asp Val Ile 
            820                 825                 830         


Asn Thr Ala Leu Pro Ile Glu Tyr Gly Pro Leu Val Glu Glu Glu Glu 
        835                 840                 845             


Lys Val Pro Val Arg Pro Lys Asp Pro Glu Gly Val Pro Pro Leu Leu 
    850                 855                 860                 


Val Ser Gln Gln Ala Lys Arg Glu Glu Glu Arg Ser Pro Ala Ala Pro 
865                 870                 875                 880 


Pro Pro Leu Pro Thr Thr Ser Ser Gly Lys Ala Ala Lys Lys Pro Thr 
                885                 890                 895     


Ala Ala Glu Val Ser Val Arg Val Pro Arg Gly Pro Ala Val Glu Gly 
            900                 905                 910         


Gly His Val Asn Met Ala Phe Ser Gln Ser Asn Pro Pro Ser Glu Leu 
        915                 920                 925             


His Arg Val His Gly Ser Arg Asn Lys Pro Thr Ser Leu Trp Asn Pro 
    930                 935                 940                 


Thr Tyr Gly Ser Trp Phe Thr Glu Lys Pro Thr Lys Lys Asn Asn Pro 
945                 950                 955                 960 


Ile Ala Lys Lys Glu Pro His Glu Arg Gly Asn Leu Gly Leu Glu Gly 
                965                 970                 975     


Ser Cys Thr Val Pro Pro Asn Val Ala Thr Gly Arg Leu Pro Gly Ala 
            980                 985                 990         


Ser Leu Leu Leu Glu Pro Ser Ser  Leu Thr Ala Asn Met  Lys Glu Val 
        995                 1000                 1005             


Pro Leu  Phe Arg Leu Arg His  Phe Pro Cys Gly Asn  Val Asn Tyr 
    1010                 1015                 1020             


Gly Tyr  Gln Gln Gln Gly Leu  Pro Leu Glu Ala Ala  Thr Ala Pro 
    1025                 1030                 1035             


Gly Ala  Gly His Tyr Glu Asp  Thr Ile Leu Lys Ser  Lys Asn Ser 
    1040                 1045                 1050             


Met Asn  Gln Pro Gly Pro 
    1055                 


<210> 106
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 106
gacatccaga tgactcagtc tccagcctcc ctggctgcat ctgtgggaga aactgtcacc       60

atcacatgtc gagcaagtga gaacatttac tacagtttag catggtatca gcagaagcaa      120

gggaaatctc ctcagctcct gatctataat gcaaacagct tggaagatgg tgtcccatcg      180

aggttcagtg gcagtggatc tgggacacag tattctatga agatcaacag catgcagcct      240

gaagataccg caacttattt ctgtaaacag gcttatgacg ttccattcac gttcggctcg      300

gggacaaagt tggaaataaa acgg                                             324


<210> 107
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 107
gctatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gtgtaagtca gggcattagc aattctttaa actggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctattac acatcaagtt tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tgggacagat tattctctca ccatcagcaa cctggaacct      240

gaagatattg ccacttacta ttgtcagcag tatagtaagc ttccgctcac gttcggtgct      300

gggaccaagc tggagctgaa acgg                                             324


<210> 108
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 108
gacattgtga tgacccagtc tcaaagattc atgtccacat cagtaggaga cagggtcagc       60

gtcacctgca aggccagtca gaatgtgggt actaatgtag cctggtatca acagaaacca      120

gggcaatctc ctaaagcact gatttactcg gcatcctacc ggtacagtgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccgtcagcaa tgtgcagtct      240

gaagacttgg cagagtattt ctgtcagcaa tataacagct atccgtacat gtacacgttc      300

ggagggggga ccaagctgga aataaaacgg                                       330


<210> 109
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 109
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca gagccagcga aagtgttgat aattatggca ttagttttat gaactggttc      120

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa ccaaggatcc      180

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat      240

cctatggagg aggatgatac tgcaatgtat ttctgtcagc aaagtaagga ggttccgtgg      300

acgttcggtg gaggcaccaa gctggaaatc aaacgg                                336


<210> 110
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 110
gacattgtga tgacccagtc tcaaagattc atgtccacat cagtaggaga cagggtcagc       60

gtcacctgca aggccagtca gaatgtgggt actaatgtag cctggtatca acagaaacca      120

gggcaatctc ctaaagcact gatttactcg gcatcctacc ggtacagtgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct      240

gaagacttgg cagagtattt ctgtcaacaa tataacagct atccgtacat gtacacgttc      300

ggagggggga ccaagctgga aataaaacgg                                       330


<210> 111
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 111
gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcagc       60

atcacctgta aggccagtca gaatgtgggt actgctgtag cctggtatca actgaaacca      120

ggacaatctc ctaaactact gatttactcg gcatccaatc ggttcactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tatgcagtct      240

gaagacctgg cagattattt ctgccagcaa tatagcagct atcctctcac gttcggctcg      300

gggacaaagt tggaaataaa acgg                                             324


<210> 112
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 112
gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcagc       60

gtcacctgca aggccagtca gaatgtgggt actaatgtag cctggtatca acagaaacca      120

gggcactctc ctaaagcact gatttactcg gcatcctacc ggtacagtgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct      240

gaagacttgg cagagtattt ctgtcagcga tataacagct atccgtacat gttcacgttc      300

ggagggggga ccaagctgga aataaaacgg                                       330


<210> 113
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 113
caggttcagc tgcagcagtc tggggctgag ctggtgaagc ctggggcctc agtgaagatt       60

tcctgcaaag cttctggcta cgcattcagt agctactgga tgaactgggt gaagcagagg      120

cctggaaagg gtcttgagtg gattggacag atttatcctg gagatggtga tactaactac      180

aacggaaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac ctctgaggac tctgcggtct atttctgtgc ctcttattac      300

tacggtagta aggcttactg gggccaaggg actctggtca ctgtctctgc a               351


<210> 114
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 114
caggtccaac tgcagcagcc tggggctgag tttgtgaagc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggcta caccttcacc agctactgga tgcactgggt gaagcagagg      120

cctggacgag gccttgagtg gattggaagg attgatccta atagtggtgg tactaagtac      180

aatgagaagt tcaagagcaa ggccacactg actgtagaca aaccctccag cacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgcggtct attattgtgc aagagattac      300

tacggtagta gctaccggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      360


<210> 115
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 115
caggtccagc tgcagcagtc tggggctgaa ctggcaaaac ctggggcctc agtgaagctg       60

tcctgcaagg cttctggcta cacctttact aactactgga tgcactgggt aaaacagagg      120

cctggacagg gtctggaatg gattggatac attaatccta gcagtggtta tactaagtac      180

aatcagaagt tcaaggacaa ggccacattg actgcagaca aatcctccag cacagcctac      240

atgcagctga gcagcctgac atatgaggac tctgcagtct attactgtgc aagagattac      300

tacggtagta gctcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      360


<210> 116
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 116
caggttcagc tgcaacagtc tggggctgag ctggtgaagc ctggggcctc agtgaagatt       60

tcctgcaaag cttctggcta cgcattcagt agctactggg tgaactgggt gaagcagagg      120

cctggaaagg gtcttgagtg gattggacag atttatcctg gagatggtga tactaactac      180

aacggaaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac ctctgaggac tctgcggtct atttctgtgc aagatcaaga      300

gggtatttct acggtagtac ctacgactcc tggggccaag gcaccactct cacagtctcc      360

tca                                                                    363


<210> 117
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 117
caggtccagc tgcagcagtc tggggctgaa ctggcaaaac ctggggcctc agtgaagctg       60

tcctgcaagg cttctggcta cacctttact agctactgga tgcactgggt aaaacagagg      120

cctggacagg gtctggaatg gattggatac attaagccta gcagtggtta tactaagtac      180

aatcagaagt tcaaggacaa ggccacattg actgcagaca aatcctccag cacagcctac      240

atgcagctga gcagcctgac atatgaggac tctgcagtct attactgtgc aagagattac      300

tacggtagta gctcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      360


<210> 118
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 118
gacgtgaagc tggtggagtc tggggaaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt agctatgcca tgtcttgggt tcgccagact      120

ccagagaaga ggctggagtg ggtcacatac attagtagtg gtggtgatta catctactat      180

gcagacactg tgaagggccg attcaccatc tccagagaca atgccaggaa caccctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acagccatgt attactgtac aagagagcgg      300

atatggttac gacggttctt cgatgtctgg ggcacaggga ccacggtcac cgtctcctca      360


<210> 119
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 119
caggtccagc tgcagcagtc tggggctgaa ctggcaaaac ctggggcctc agtgaagctg       60

tcctgcaagg cttctggcta cacctttact agctactgga tgcactgggt aaaacagagg      120

cctggacagg gtctggaatg gattggatac attaatccta gcagtggtta tactaagtac      180

aatcagaagt tcaaggacaa ggccacattg actgcagaca aatcctccag cacagcctac      240

atgcagctga gcagcctgac atttgaggac tctgcagtct attactgtgc aagagattac      300

tacggtagta gctcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      360


