                         SEQUENCE LISTING

<110>  The Regents of the University of California
       ShangPharma Innovation Inc.
       Gordon, John
       Mitchell, Dominique
       Beresis, Richard
       Adler, Marc
 
<120>  STRAD-BINDING AGENTS AND USES THEREOF

<130>  048536-666001WO

<150>  US 62/967,811
<151>  2020-01-30

<150>  US 63/028,242
<151>  2020-05-21

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Met Ser Phe Leu Val Ser Lys Pro Glu Arg Ile Arg Arg Trp Val Ser 
1               5                   10                  15      


Glu Lys Phe Ile Val Glu Gly Leu Arg Asp Leu Glu Leu Phe Gly Glu 
            20                  25                  30          


Gln Pro Pro Gly Asp Thr Arg Arg Lys Thr Asn Asp Ala Ser Ser Glu 
        35                  40                  45              


Ser Ile Ala Ser Phe Ser Lys Gln Glu Val Met Ser Ser Phe Leu Pro 
    50                  55                  60                  


Glu Gly Gly Cys Tyr Glu Leu Leu Thr Val Ile Gly Lys Gly Phe Glu 
65                  70                  75                  80  


Asp Leu Met Thr Val Asn Leu Ala Arg Tyr Lys Pro Thr Gly Glu Tyr 
                85                  90                  95      


Val Thr Val Arg Arg Ile Asn Leu Glu Ala Cys Ser Asn Glu Met Val 
            100                 105                 110         


Thr Phe Leu Gln Gly Glu Leu His Val Ser Lys Leu Phe Asn His Pro 
        115                 120                 125             


Asn Ile Val Pro Tyr Arg Ala Thr Phe Ile Ala Asp Asn Glu Leu Trp 
    130                 135                 140                 


Val Val Thr Ser Phe Met Ala Tyr Gly Ser Ala Lys Asp Leu Ile Cys 
145                 150                 155                 160 


Thr His Phe Met Asp Gly Met Asn Glu Leu Ala Ile Ala Tyr Ile Leu 
                165                 170                 175     


Gln Gly Val Leu Lys Ala Leu Asp Tyr Ile His His Met Gly Tyr Val 
            180                 185                 190         


His Arg Ser Val Lys Ala Ser His Ile Leu Ile Ser Val Asp Gly Lys 
        195                 200                 205             


Val Tyr Leu Ser Gly Leu Arg Ser Asn Leu Ser Met Ile Ser His Gly 
    210                 215                 220                 


Gln Arg Gln Arg Val Val His Asp Phe Pro Lys Tyr Ser Val Lys Val 
225                 230                 235                 240 


Leu Pro Trp Leu Ser Pro Glu Val Leu Gln Gln Asn Leu Gln Gly Tyr 
                245                 250                 255     


Asp Ala Lys Ser Asp Ile Tyr Ser Val Gly Ile Thr Ala Cys Glu Leu 
            260                 265                 270         


Ala Asn Gly His Val Pro Phe Lys Asp Met Pro Ala Thr Gln Met Leu 
        275                 280                 285             


Leu Glu Lys Leu Asn Gly Thr Val Pro Cys Leu Leu Asp Thr Ser Thr 
    290                 295                 300                 


Ile Pro Ala Glu Glu Leu Thr Met Ser Pro Ser Arg Ser Val Ala Asn 
305                 310                 315                 320 


Ser Gly Leu Ser Asp Ser Leu Thr Thr Ser Thr Pro Arg Pro Ser Asn 
                325                 330                 335     


Gly Asp Ser Pro Ser His Pro Tyr His Arg Thr Phe Pro His Phe His 
            340                 345                 350         


His Phe Val Glu Gln Cys Leu Gln Arg Asn Pro Asp Ala Arg Pro Ser 
        355                 360                 365             


Ala Ser Thr Leu Leu Asn His Ser Phe Phe Lys Gln Ile Lys Arg Arg 
    370                 375                 380                 


Ala Ser Glu Ala Leu Pro Glu Leu Leu Arg Pro Val Thr Pro Ile Thr 
385                 390                 395                 400 


Asn Phe Glu Gly Ser Gln Ser Gln Asp His Ser Gly Ile Phe Gly Leu 
                405                 410                 415     


Val Asn Leu Glu Glu Leu Glu Val Asp Asp Trp Glu Phe 
            420                 425                 


<210>  2
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Met Ser Phe Leu Val Ser Lys Pro Glu Arg Ile Arg Arg Trp Val Ser 
1               5                   10                  15      


Glu Lys Phe Ile Val Glu Gly Leu Arg Asp Leu Glu Leu Phe Gly Glu 
            20                  25                  30          


Gln Pro Pro Gly Asp Thr Arg Arg Lys Thr Asn Asp Ala Ser Ser Glu 
        35                  40                  45              


Ser Ile Ala Ser Phe Ser Lys Gln Glu Val Met Ser Ser Phe Leu Pro 
    50                  55                  60                  


Glu Gly Gly Cys Tyr Glu Leu Leu Thr Val Ile Gly Lys Gly Phe Glu 
65                  70                  75                  80  


Asp Leu Met Thr Val Asn Leu Ala Arg Tyr Lys Pro Thr Gly Glu Tyr 
                85                  90                  95      


Val Thr Val Arg Arg Ile Asn Leu Glu Ala Cys Ser Asn Glu Met Val 
            100                 105                 110         


Thr Phe Leu Gln Gly Glu Leu His Val Ser Lys Leu Phe Asn His Pro 
        115                 120                 125             


Asn Ile Val Pro Tyr Arg Ala Thr Phe Ile Ala Asp Asn Glu Leu Trp 
    130                 135                 140                 


Val Val Thr Ser Phe Met Ala Tyr Gly Ser Ala Lys Asp Leu Ile Cys 
145                 150                 155                 160 


Thr His Phe Met Asp Gly Met Asn Glu Leu Ala Ile Ala Tyr Ile Leu 
                165                 170                 175     


Gln Gly Val Leu Lys Ala Leu Asp Tyr Ile His His Met Gly Tyr Val 
            180                 185                 190         


His Arg Ser Val Lys Ala Ser His Ile Leu Ile Ser Val Asp Gly Lys 
        195                 200                 205             


Val Tyr Leu Ser Gly Leu Arg Ser Asn Leu Ser Met Ile Ser His Gly 
    210                 215                 220                 


Gln Arg Gln Arg Val Val His Asp Phe Pro Lys Tyr Ser Val Lys Val 
225                 230                 235                 240 


Leu Pro Trp Leu Ser Pro Glu Val Leu Gln Gln Asn Leu Gln Gly Tyr 
                245                 250                 255     


Asp Ala Lys Ser Asp Ile Tyr Ser Val Gly Ile Thr Ala Cys Glu Leu 
            260                 265                 270         


Ala Asn Gly His Val Pro Phe Lys Asp Met Pro Ala Thr Gln Met Leu 
        275                 280                 285             


Leu Glu Lys Leu Asn Gly Thr Val Pro Cys Leu Leu Asp Thr Ser Thr 
    290                 295                 300                 


Ile Pro Ala Glu Glu Leu Thr Met Ser Pro Ser Arg Ser Val Ala Asn 
305                 310                 315                 320 


Ser Gly Leu Ser Asp Ser Leu Thr Thr Ser Thr Pro Arg Pro Ser Asn 
                325                 330                 335     


Gly Asp Ser Pro Ser His Pro Tyr His Arg Thr Phe Ser Pro His Phe 
            340                 345                 350         


His His Phe Val Glu Gln Cys Leu Gln Arg Asn Pro Asp Ala Arg Pro 
        355                 360                 365             


Ser Ala Ser Thr Leu Leu Asn His Ser Phe Phe Lys Gln Ile Lys Arg 
    370                 375                 380                 


Arg Ala Ser Glu Ala Leu Pro Glu Leu Leu Arg Pro Val Thr Pro Ile 
385                 390                 395                 400 


Thr Asn Phe Glu Gly Ser Gln Ser Gln Asp His Ser Gly Ile Phe Gly 
                405                 410                 415     


Leu Val Thr Asn Leu Glu Glu Leu Glu Val Asp Asp Trp Glu Phe 
            420                 425                 430     


<210>  3
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Met Glu Val Val Asp Pro Gln Gln Leu Gly Met Phe Thr Glu Gly Glu 
1               5                   10                  15      


Leu Met Ser Val Gly Met Asp Thr Phe Ile His Arg Ile Asp Ser Thr 
            20                  25                  30          


Glu Val Ile Tyr Gln Pro Arg Arg Lys Arg Ala Lys Leu Ile Gly Lys 
        35                  40                  45              


Tyr Leu Met Gly Asp Leu Leu Gly Glu Gly Ser Tyr Gly Lys Val Lys 
    50                  55                  60                  


Glu Val Leu Asp Ser Glu Thr Leu Cys Arg Arg Ala Val Lys Ile Leu 
65                  70                  75                  80  


Lys Lys Lys Lys Leu Arg Arg Ile Pro Asn Gly Glu Ala Asn Val Lys 
                85                  90                  95      


Lys Glu Ile Gln Leu Leu Arg Arg Leu Arg His Lys Asn Val Ile Gln 
            100                 105                 110         


Leu Val Asp Val Leu Tyr Asn Glu Glu Lys Gln Lys Met Tyr Met Val 
        115                 120                 125             


Met Glu Tyr Cys Val Cys Gly Met Gln Glu Met Leu Asp Ser Val Pro 
    130                 135                 140                 


Glu Lys Arg Phe Pro Val Cys Gln Ala His Gly Tyr Phe Cys Gln Leu 
145                 150                 155                 160 


Ile Asp Gly Leu Glu Tyr Leu His Ser Gln Gly Ile Val His Lys Asp 
                165                 170                 175     


Ile Lys Pro Gly Asn Leu Leu Leu Thr Thr Gly Gly Thr Leu Lys Ile 
            180                 185                 190         


Ser Asp Leu Gly Val Ala Glu Ala Leu His Pro Phe Ala Ala Asp Asp 
        195                 200                 205             


Thr Cys Arg Thr Ser Gln Gly Ser Pro Ala Phe Gln Pro Pro Glu Ile 
    210                 215                 220                 


Ala Asn Gly Leu Asp Thr Phe Ser Gly Phe Lys Val Asp Ile Trp Ser 
225                 230                 235                 240 


Ala Gly Val Thr Leu Tyr Asn Ile Thr Thr Gly Leu Tyr Pro Phe Glu 
                245                 250                 255     


Gly Asp Asn Ile Tyr Lys Leu Phe Glu Asn Ile Gly Lys Gly Ser Tyr 
            260                 265                 270         


Ala Ile Pro Gly Asp Cys Gly Pro Pro Leu Ser Asp Leu Leu Lys Gly 
        275                 280                 285             


Met Leu Glu Tyr Glu Pro Ala Lys Arg Phe Ser Ile Arg Gln Ile Arg 
    290                 295                 300                 


Gln His Ser Trp Phe Arg Lys Lys His Pro Pro Ala Glu Ala Pro Val 
305                 310                 315                 320 


Pro Ile Pro Pro Ser Pro Asp Thr Lys Asp Arg Trp Arg Ser Met Thr 
                325                 330                 335     


Val Val Pro Tyr Leu Glu Asp Leu His Gly Ala Asp Glu Asp Glu Asp 
            340                 345                 350         


Leu Phe Asp Ile Glu Asp Asp Ile Ile Tyr Thr Gln Asp Phe Thr Val 
        355                 360                 365             


Pro Gly Gln Val Pro Glu Glu Glu Ala Ser His Asn Gly Gln Arg Arg 
    370                 375                 380                 


Gly Leu Pro Lys Ala Val Cys Met Asn Gly Thr Glu Ala Ala Gln Leu 
385                 390                 395                 400 


Ser Thr Lys Ser Arg Ala Glu Gly Arg Ala Pro Asn Pro Ala Arg Lys 
                405                 410                 415     


Ala Cys Ser Ala Ser Ser Lys Ile Arg Arg Leu Ser Ala Cys Lys Gln 
            420                 425                 430         


Gln 
    


<210>  4
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Met Pro Phe Pro Phe Gly Lys Ser His Lys Ser Pro Ala Asp Ile Val 
1               5                   10                  15      


Lys Asn Leu Lys Glu Ser Met Ala Val Leu Glu Lys Gln Asp Ile Ser 
            20                  25                  30          


Asp Lys Lys Ala Glu Lys Ala Thr Glu Glu Val Ser Lys Asn Leu Val 
        35                  40                  45              


Ala Met Lys Glu Ile Leu Tyr Gly Thr Asn Glu Lys Glu Pro Gln Thr 
    50                  55                  60                  


Glu Ala Val Ala Gln Leu Ala Gln Glu Leu Tyr Asn Ser Gly Leu Leu 
65                  70                  75                  80  


Ser Thr Leu Val Ala Asp Leu Gln Leu Ile Asp Phe Glu Gly Lys Lys 
                85                  90                  95      


Asp Val Ala Gln Ile Phe Asn Asn Ile Leu Arg Arg Gln Ile Gly Thr 
            100                 105                 110         


Arg Thr Pro Thr Val Glu Tyr Ile Cys Thr Gln Gln Asn Ile Leu Phe 
        115                 120                 125             


Met Leu Leu Lys Gly Tyr Glu Ser Pro Glu Ile Ala Leu Asn Cys Gly 
    130                 135                 140                 


Ile Met Leu Arg Glu Cys Ile Arg His Glu Pro Leu Ala Lys Ile Ile 
145                 150                 155                 160 


Leu Trp Ser Glu Gln Phe Tyr Asp Phe Phe Arg Tyr Val Glu Met Ser 
                165                 170                 175     


Thr Phe Asp Ile Ala Ser Asp Ala Phe Ala Thr Phe Lys Asp Leu Leu 
            180                 185                 190         


Thr Arg His Lys Leu Leu Ser Ala Glu Phe Leu Glu Gln His Tyr Asp 
        195                 200                 205             


Arg Phe Phe Ser Glu Tyr Glu Lys Leu Leu His Ser Glu Asn Tyr Val 
    210                 215                 220                 


Thr Lys Arg Gln Ser Leu Lys Leu Leu Gly Glu Leu Leu Leu Asp Arg 
225                 230                 235                 240 


His Asn Phe Thr Ile Met Thr Lys Tyr Ile Ser Lys Pro Glu Asn Leu 
                245                 250                 255     


Lys Leu Met Met Asn Leu Leu Arg Asp Lys Ser Arg Asn Ile Gln Phe 
            260                 265                 270         


Glu Ala Phe His Val Phe Lys Val Phe Val Ala Asn Pro Asn Lys Thr 
        275                 280                 285             


Gln Pro Ile Leu Asp Ile Leu Leu Lys Asn Gln Ala Lys Leu Ile Glu 
    290                 295                 300                 


Phe Leu Ser Lys Phe Gln Asn Asp Arg Thr Glu Asp Glu Gln Phe Asn 
305                 310                 315                 320 


Asp Glu Lys Thr Tyr Leu Val Lys Gln Ile Arg Asp Leu Lys Arg Pro 
                325                 330                 335     


Ala Gln Gln Glu Ala 
            340     


<210>  5
<211>  693
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Met Ala Thr Ser Gly Ala Asn Gly Pro Gly Ser Ala Thr Ala Ser Ala 
1               5                   10                  15      


Ser Asn Pro Arg Lys Phe Ser Glu Lys Ile Ala Leu Gln Lys Gln Arg 
            20                  25                  30          


Gln Ala Glu Glu Thr Ala Ala Phe Glu Glu Val Met Met Asp Ile Gly 
        35                  40                  45              


Ser Thr Arg Leu Gln Ala Gln Lys Leu Arg Leu Ala Tyr Thr Arg Ser 
    50                  55                  60                  


Ser His Tyr Gly Gly Ser Leu Pro Asn Val Asn Gln Ile Gly Ser Gly 
65                  70                  75                  80  


Leu Ala Glu Phe Gln Ser Pro Leu His Ser Pro Leu Asp Ser Ser Arg 
                85                  90                  95      


Ser Thr Arg His His Gly Leu Val Glu Arg Val Gln Arg Asp Pro Arg 
            100                 105                 110         


Arg Met Val Ser Pro Leu Arg Arg Tyr Thr Arg His Ile Asp Ser Ser 
        115                 120                 125             


Pro Tyr Ser Pro Ala Tyr Leu Ser Pro Pro Pro Glu Ser Ser Trp Arg 
    130                 135                 140                 


Arg Thr Met Ala Trp Gly Asn Phe Pro Ala Glu Lys Gly Gln Leu Phe 
145                 150                 155                 160 


Arg Leu Pro Ser Ala Leu Asn Arg Thr Ser Ser Asp Ser Ala Leu His 
                165                 170                 175     


Thr Ser Val Met Asn Pro Ser Pro Gln Asp Thr Tyr Pro Gly Pro Thr 
            180                 185                 190         


Pro Pro Ser Ile Leu Pro Ser Arg Arg Gly Gly Ile Leu Asp Gly Glu 
        195                 200                 205             


Met Asp Pro Lys Val Pro Ala Ile Glu Glu Asn Leu Leu Asp Asp Lys 
    210                 215                 220                 


His Leu Leu Lys Pro Trp Asp Ala Lys Lys Leu Ser Ser Ser Ser Ser 
225                 230                 235                 240 


Arg Pro Arg Ser Cys Glu Val Pro Gly Ile Asn Ile Phe Pro Ser Pro 
                245                 250                 255     


Asp Gln Pro Ala Asn Val Pro Val Leu Pro Pro Ala Met Asn Thr Gly 
            260                 265                 270         


Gly Ser Leu Pro Asp Leu Thr Asn Leu His Phe Pro Pro Pro Leu Pro 
        275                 280                 285             


Thr Pro Leu Asp Pro Glu Glu Thr Ala Tyr Pro Ser Leu Ser Gly Gly 
    290                 295                 300                 


Asn Ser Thr Ser Asn Leu Thr His Thr Met Thr His Leu Gly Ile Ser 
305                 310                 315                 320 


Arg Gly Met Gly Leu Gly Pro Gly Tyr Asp Ala Pro Gly Leu His Ser 
                325                 330                 335     


Pro Leu Ser His Pro Ser Leu Gln Ser Ser Leu Ser Asn Pro Asn Leu 
            340                 345                 350         


Gln Ala Ser Leu Ser Ser Pro Gln Pro Gln Leu Gln Gly Ser His Ser 
        355                 360                 365             


His Pro Ser Leu Pro Ala Ser Ser Leu Ala Arg His Val Leu Pro Thr 
    370                 375                 380                 


Thr Ser Leu Gly His Pro Ser Leu Ser Ala Pro Ala Leu Ser Ser Ser 
385                 390                 395                 400 


Ser Ser Ser Ser Ser Thr Ser Ser Pro Val Leu Gly Ala Pro Ser Tyr 
                405                 410                 415     


Pro Ala Ser Thr Pro Gly Ala Ser Pro His His Arg Arg Val Pro Leu 
            420                 425                 430         


Ser Pro Leu Ser Leu Leu Ala Gly Pro Ala Asp Ala Arg Arg Ser Gln 
        435                 440                 445             


Gln Gln Leu Pro Lys Gln Phe Ser Pro Thr Met Ser Pro Thr Leu Ser 
    450                 455                 460                 


Ser Ile Thr Gln Gly Val Pro Leu Asp Thr Ser Lys Leu Ser Thr Asp 
465                 470                 475                 480 


Gln Arg Leu Pro Pro Tyr Pro Tyr Ser Ser Pro Ser Leu Val Leu Pro 
                485                 490                 495     


Thr Gln Pro His Thr Pro Lys Ser Leu Gln Gln Pro Gly Leu Pro Ser 
            500                 505                 510         


Gln Ser Cys Ser Val Gln Ser Ser Gly Gly Gln Pro Pro Gly Arg Gln 
        515                 520                 525             


Ser His Tyr Gly Thr Pro Tyr Pro Pro Gly Pro Ser Gly His Gly Gln 
    530                 535                 540                 


Gln Ser Tyr His Arg Pro Met Ser Asp Phe Asn Leu Gly Asn Leu Glu 
545                 550                 555                 560 


Gln Phe Ser Met Glu Ser Pro Ser Ala Ser Leu Val Leu Asp Pro Pro 
                565                 570                 575     


Gly Phe Ser Glu Gly Pro Gly Phe Leu Gly Gly Glu Gly Pro Met Gly 
            580                 585                 590         


Gly Pro Gln Asp Pro His Thr Phe Asn His Gln Asn Leu Thr His Cys 
        595                 600                 605             


Ser Arg His Gly Ser Gly Pro Asn Ile Ile Leu Thr Gly Asp Ser Ser 
    610                 615                 620                 


Pro Gly Phe Ser Lys Glu Ile Ala Ala Ala Leu Ala Gly Val Pro Gly 
625                 630                 635                 640 


Phe Glu Val Ser Ala Ala Gly Leu Glu Leu Gly Leu Gly Leu Glu Asp 
                645                 650                 655     


Glu Leu Arg Met Glu Pro Leu Gly Leu Glu Gly Leu Asn Met Leu Ser 
            660                 665                 670         


Asp Pro Cys Ala Leu Leu Pro Asp Pro Ala Val Glu Glu Ser Phe Arg 
        675                 680                 685             


Ser Asp Arg Leu Gln 
    690             


<210>  6
<211>  650
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Met Ala Thr Ser Asn Asn Pro Arg Lys Phe Ser Glu Lys Ile Ala Leu 
1               5                   10                  15      


His Asn Gln Lys Gln Ala Glu Glu Thr Ala Ala Phe Glu Glu Val Met 
            20                  25                  30          


Lys Asp Leu Ser Leu Thr Arg Ala Ala Arg Leu Gln Leu Gln Lys Ser 
        35                  40                  45              


Gln Tyr Leu Gln Leu Gly Pro Ser Arg Gly Gln Tyr Tyr Gly Gly Ser 
    50                  55                  60                  


Leu Pro Asn Val Asn Gln Ile Gly Ser Gly Thr Met Asp Leu Pro Phe 
65                  70                  75                  80  


Gln Pro Ser Gly Phe Leu Gly Glu Ala Leu Ala Ala Ala Pro Val Ser 
                85                  90                  95      


Leu Thr Pro Phe Gln Ser Ser Gly Leu Asp Thr Ser Arg Thr Thr Arg 
            100                 105                 110         


His His Gly Leu Val Asp Arg Val Tyr Arg Glu Arg Gly Arg Leu Gly 
        115                 120                 125             


Ser Pro His Arg Arg Pro Leu Ser Val Asp Lys His Gly Arg Gln Ala 
    130                 135                 140                 


Asp Ser Cys Pro Tyr Gly Thr Met Tyr Leu Ser Pro Pro Ala Asp Thr 
145                 150                 155                 160 


Ser Trp Arg Arg Thr Asn Ser Asp Ser Ala Leu His Gln Ser Thr Met 
                165                 170                 175     


Thr Pro Thr Gln Pro Glu Ser Phe Ser Ser Gly Ser Gln Asp Val His 
            180                 185                 190         


Gln Lys Arg Val Leu Leu Leu Thr Val Pro Gly Met Glu Glu Thr Thr 
        195                 200                 205             


Ser Glu Ala Asp Lys Asn Leu Ser Lys Gln Ala Trp Asp Thr Lys Lys 
    210                 215                 220                 


Thr Gly Ser Arg Pro Lys Ser Cys Glu Val Pro Gly Ile Asn Ile Phe 
225                 230                 235                 240 


Pro Ser Ala Asp Gln Glu Asn Thr Thr Ala Leu Ile Pro Ala Thr His 
                245                 250                 255     


Asn Thr Gly Gly Ser Leu Pro Asp Leu Thr Asn Ile His Phe Pro Ser 
            260                 265                 270         


Pro Leu Pro Thr Pro Leu Asp Pro Glu Glu Pro Thr Phe Pro Ala Leu 
        275                 280                 285             


Ser Ser Ser Ser Ser Thr Gly Asn Leu Ala Ala Asn Leu Thr His Leu 
    290                 295                 300                 


Gly Ile Gly Gly Ala Gly Gln Gly Met Ser Thr Pro Gly Ser Ser Pro 
305                 310                 315                 320 


Gln His Arg Pro Ala Gly Val Ser Pro Leu Ser Leu Ser Thr Glu Ala 
                325                 330                 335     


Arg Arg Gln Gln Ala Ser Pro Thr Leu Ser Pro Leu Ser Pro Ile Thr 
            340                 345                 350         


Gln Ala Val Ala Met Asp Ala Leu Ser Leu Glu Gln Gln Leu Pro Tyr 
        355                 360                 365             


Ala Phe Phe Thr Gln Ala Gly Ser Gln Gln Pro Pro Pro Gln Pro Gln 
    370                 375                 380                 


Pro Pro Pro Pro Pro Pro Pro Ala Ser Gln Gln Pro Pro Pro Pro Pro 
385                 390                 395                 400 


Pro Pro Gln Ala Pro Val Arg Leu Pro Pro Gly Gly Pro Leu Leu Pro 
                405                 410                 415     


Ser Ala Ser Leu Thr Arg Gly Pro Gln Pro Pro Pro Leu Ala Val Thr 
            420                 425                 430         


Val Pro Ser Ser Leu Pro Gln Ser Pro Pro Glu Asn Pro Gly Gln Pro 
        435                 440                 445             


Ser Met Gly Ile Asp Ile Ala Ser Ala Pro Ala Leu Gln Gln Tyr Arg 
    450                 455                 460                 


Thr Ser Ala Gly Ser Pro Ala Asn Gln Ser Pro Thr Ser Pro Val Ser 
465                 470                 475                 480 


Asn Gln Gly Phe Ser Pro Gly Ser Ser Pro Gln His Thr Ser Thr Leu 
                485                 490                 495     


Gly Ser Val Phe Gly Asp Ala Tyr Tyr Glu Gln Gln Met Ala Ala Arg 
            500                 505                 510         


Gln Ala Asn Ala Leu Ser His Gln Leu Glu Gln Phe Asn Met Met Glu 
        515                 520                 525             


Asn Ala Ile Ser Ser Ser Ser Leu Tyr Ser Pro Gly Ser Thr Leu Asn 
    530                 535                 540                 


Tyr Ser Gln Ala Ala Met Met Gly Leu Thr Gly Ser His Gly Ser Leu 
545                 550                 555                 560 


Pro Asp Ser Gln Gln Leu Gly Tyr Ala Ser His Ser Gly Ile Pro Asn 
                565                 570                 575     


Ile Ile Leu Thr Val Thr Gly Glu Ser Pro Pro Ser Leu Ser Lys Glu 
            580                 585                 590         


Leu Thr Ser Ser Leu Ala Gly Val Gly Asp Val Ser Phe Asp Ser Asp 
        595                 600                 605             


Ser Gln Phe Pro Leu Asp Glu Leu Lys Ile Asp Pro Leu Thr Leu Asp 
    610                 615                 620                 


Gly Leu His Met Leu Asn Asp Pro Asp Met Val Leu Ala Asp Pro Ala 
625                 630                 635                 640 


Thr Glu Asp Thr Phe Arg Met Asp Arg Leu 
                645                 650 


<210>  7
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Met Ala Ala Ser Pro Gly Ser Gly Ser Ala Asn Pro Arg Lys Phe Ser 
1               5                   10                  15      


Glu Lys Ile Ala Leu His Thr Gln Arg Gln Ala Glu Glu Thr Arg Ala 
            20                  25                  30          


Phe Glu Gln Leu Met Thr Asp Leu Thr Leu Ser Arg Val Gln Phe Gln 
        35                  40                  45              


Lys Leu Gln Gln Leu Arg Leu Thr Gln Tyr His Gly Gly Ser Leu Pro 
    50                  55                  60                  


Asn Val Ser Gln Leu Arg Ser Ser Ala Ser Glu Phe Gln Pro Ser Phe 
65                  70                  75                  80  


His Gln Ala Asp Asn Val Arg Gly Thr Arg His His Gly Leu Val Glu 
                85                  90                  95      


Arg Pro Ser Arg Asn Arg Phe His Pro Leu His Arg Arg Ser Gly Asp 
            100                 105                 110         


Lys Pro Gly Arg Gln Phe Asp Gly Ser Ala Phe Gly Ala Asn Tyr Ser 
        115                 120                 125             


Ser Gln Pro Leu Asp Glu Ser Trp Pro Arg Gln Gln Pro Pro Trp Lys 
    130                 135                 140                 


Asp Glu Lys His Pro Gly Phe Arg Leu Thr Ser Ala Leu Asn Arg Thr 
145                 150                 155                 160 


Asn Ser Asp Ser Ala Leu His Thr Ser Ala Leu Ser Thr Lys Pro Gln 
                165                 170                 175     


Asp Pro Tyr Gly Gly Gly Gly Gln Ser Ala Trp Pro Ala Pro Tyr Met 
            180                 185                 190         


Gly Phe Cys Asp Gly Glu Asn Asn Gly His Gly Glu Val Ala Ser Phe 
        195                 200                 205             


Pro Gly Pro Leu Lys Glu Glu Asn Leu Leu Asn Val Pro Lys Pro Leu 
    210                 215                 220                 


Pro Lys Gln Leu Trp Glu Thr Lys Glu Ile Gln Ser Leu Ser Gly Arg 
225                 230                 235                 240 


Pro Arg Ser Cys Asp Val Gly Gly Gly Asn Ala Phe Pro His Asn Gly 
                245                 250                 255     


Gln Asn Leu Gly Leu Ser Pro Phe Leu Gly Thr Leu Asn Thr Gly Gly 
            260                 265                 270         


Ser Leu Pro Asp Leu Thr Asn Leu His Tyr Ser Thr Pro Leu Pro Ala 
        275                 280                 285             


Ser Leu Asp Thr Thr Asp His His Phe Gly Ser Met Ser Val Gly Asn 
    290                 295                 300                 


Ser Val Asn Asn Ile Pro Ala Ala Met Thr His Leu Gly Ile Arg Ser 
305                 310                 315                 320 


Ser Ser Gly Leu Gln Ser Ser Arg Ser Asn Pro Ser Ile Gln Ala Thr 
                325                 330                 335     


Leu Asn Lys Thr Val Leu Ser Ser Ser Leu Asn Asn His Pro Gln Thr 
            340                 345                 350         


Ser Val Pro Asn Ala Ser Ala Leu His Pro Ser Leu Arg Leu Phe Ser 
        355                 360                 365             


Leu Ser Asn Pro Ser Leu Ser Thr Thr Asn Leu Ser Gly Pro Ser Arg 
    370                 375                 380                 


Arg Arg Gln Pro Pro Val Ser Pro Leu Thr Leu Ser Pro Gly Pro Glu 
385                 390                 395                 400 


Ala His Gln Gly Phe Ser Arg Gln Leu Ser Ser Thr Ser Pro Leu Ala 
                405                 410                 415     


Pro Tyr Pro Thr Ser Gln Met Val Ser Ser Asp Arg Ser Gln Leu Ser 
            420                 425                 430         


Phe Leu Pro Thr Glu Ala Gln Ala Gln Val Ser Pro Pro Pro Pro Tyr 
        435                 440                 445             


Pro Ala Pro Gln Glu Leu Thr Gln Pro Leu Leu Gln Gln Pro Arg Ala 
    450                 455                 460                 


Pro Glu Ala Pro Ala Gln Gln Pro Gln Ala Ala Ser Ser Leu Pro Gln 
465                 470                 475                 480 


Ser Asp Phe Gln Leu Leu Pro Ala Gln Gly Ser Ser Leu Thr Asn Phe 
                485                 490                 495     


Phe Pro Asp Val Gly Phe Asp Gln Gln Ser Met Arg Pro Gly Pro Ala 
            500                 505                 510         


Phe Pro Gln Gln Val Pro Leu Val Gln Gln Gly Ser Arg Glu Leu Gln 
        515                 520                 525             


Asp Ser Phe His Leu Arg Pro Ser Pro Tyr Ser Asn Cys Gly Ser Leu 
    530                 535                 540                 


Pro Asn Thr Ile Leu Pro Glu Asp Ser Ser Thr Ser Leu Phe Lys Asp 
545                 550                 555                 560 


Leu Asn Ser Ala Leu Ala Gly Leu Pro Glu Val Ser Leu Asn Val Asp 
                565                 570                 575     


Thr Pro Phe Pro Leu Glu Glu Glu Leu Gln Ile Glu Pro Leu Ser Leu 
            580                 585                 590         


Asp Gly Leu Asn Met Leu Ser Asp Ser Ser Met Gly Leu Leu Asp Pro 
        595                 600                 605             


Ser Val Glu Glu Thr Phe Arg Ala Asp Arg Leu 
    610                 615                 


