                         SEQUENCE LISTING

<110>  Mantra Bio, Inc.
 
<120>  NON-NATURALLY OCCURRING VESICLES COMPRISING A CHIMERIC VESICLE
 
       LOCALIZATION MOIETY, METHODS OF MAKING AND USES THEREOF

<130>  30888.9W001

<160>  84    

<170>  PatentIn version 3.5

<210>  1
<211>  2247
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(2247)

<400>  1
atg gtg ttg ctg aga gtg tta att ctg ctc ctc tcc tgg gcg gcg ggg         48
Met Val Leu Leu Arg Val Leu Ile Leu Leu Leu Ser Trp Ala Ala Gly           
1               5                   10                  15                

atg gga ggt cag tat ggg aat cct tta aat aaa tat atc aga cat tat         96
Met Gly Gly Gln Tyr Gly Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr           
            20                  25                  30                    

gaa gga tta tct tac aat gtg gat tca tta cac caa aaa cac cag cgt        144
Glu Gly Leu Ser Tyr Asn Val Asp Ser Leu His Gln Lys His Gln Arg           
        35                  40                  45                        

gcc aaa aga gca gtc tca cat gaa gac caa ttt tta cgt cta gat ttc        192
Ala Lys Arg Ala Val Ser His Glu Asp Gln Phe Leu Arg Leu Asp Phe           
    50                  55                  60                            

cat gcc cat gga aga cat ttc aac cta cga atg aag agg gac act tcc        240
His Ala His Gly Arg His Phe Asn Leu Arg Met Lys Arg Asp Thr Ser           
65                  70                  75                  80            

ctt ttc agt gat gaa ttt aaa gta gaa aca tca aat aaa gta ctt gat        288
Leu Phe Ser Asp Glu Phe Lys Val Glu Thr Ser Asn Lys Val Leu Asp           
                85                  90                  95                

tat gat acc tct cat att tac act gga cat att tat ggt gaa gaa gga        336
Tyr Asp Thr Ser His Ile Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly           
            100                 105                 110                   

agt ttt agc cat ggg tct gtt att gat gga aga ttt gaa gga ttc atc        384
Ser Phe Ser His Gly Ser Val Ile Asp Gly Arg Phe Glu Gly Phe Ile           
        115                 120                 125                       

cag act cgt ggt ggc aca ttt tat gtt gag cca gca gag aga tat att        432
Gln Thr Arg Gly Gly Thr Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile           
    130                 135                 140                           

aaa gac cga act ctg cca ttt cac tct gtc att tat cat gaa gat gat        480
Lys Asp Arg Thr Leu Pro Phe His Ser Val Ile Tyr His Glu Asp Asp           
145                 150                 155                 160           

att aac tat ccc cat aaa tac ggt cct cag ggg ggc tgt gca gat cat        528
Ile Asn Tyr Pro His Lys Tyr Gly Pro Gln Gly Gly Cys Ala Asp His           
                165                 170                 175               

tca gta ttt gaa aga atg agg aaa tac cag atg act ggt gta gag gaa        576
Ser Val Phe Glu Arg Met Arg Lys Tyr Gln Met Thr Gly Val Glu Glu           
            180                 185                 190                   

gta aca cag ata cct caa gaa gaa cat gct gct aat ggt cca gaa ctt        624
Val Thr Gln Ile Pro Gln Glu Glu His Ala Ala Asn Gly Pro Glu Leu           
        195                 200                 205                       

ctg agg aaa aaa cgt aca act tca gct gaa aaa aat act tgt cag ctt        672
Leu Arg Lys Lys Arg Thr Thr Ser Ala Glu Lys Asn Thr Cys Gln Leu           
    210                 215                 220                           

tat att cag act gat cat ttg ttc ttt aaa tat tac gga aca cga gaa        720
Tyr Ile Gln Thr Asp His Leu Phe Phe Lys Tyr Tyr Gly Thr Arg Glu           
225                 230                 235                 240           

gct gtg att gcc cag ata tcc agt cat gtt aaa gcg att gat aca att        768
Ala Val Ile Ala Gln Ile Ser Ser His Val Lys Ala Ile Asp Thr Ile           
                245                 250                 255               

tac cag acc aca gac ttc tcc gga atc cgt aac atc agt ttc atg gtg        816
Tyr Gln Thr Thr Asp Phe Ser Gly Ile Arg Asn Ile Ser Phe Met Val           
            260                 265                 270                   

aaa cgc ata aga atc aat aca act gct gat gag aag gac cct aca aat        864
Lys Arg Ile Arg Ile Asn Thr Thr Ala Asp Glu Lys Asp Pro Thr Asn           
        275                 280                 285                       

cct ttc cgt ttc cca aat att ggt gtg gag aag ttt ctg gaa ttg aat        912
Pro Phe Arg Phe Pro Asn Ile Gly Val Glu Lys Phe Leu Glu Leu Asn           
    290                 295                 300                           

tct gag cag aat cat gat gac tac tgt ttg gcc tat gtc ttc aca gac        960
Ser Glu Gln Asn His Asp Asp Tyr Cys Leu Ala Tyr Val Phe Thr Asp           
305                 310                 315                 320           

cga gat ttt gat gat ggc gta ctt ggt ctg gct tgg gtt gga gca cct       1008
Arg Asp Phe Asp Asp Gly Val Leu Gly Leu Ala Trp Val Gly Ala Pro           
                325                 330                 335               

tca gga agc tct gga gga ata tgt gaa aaa agt aaa ctc tat tca gat       1056
Ser Gly Ser Ser Gly Gly Ile Cys Glu Lys Ser Lys Leu Tyr Ser Asp           
            340                 345                 350                   

ggt aag aag aag tcc tta aac act gga att att act gtt cag aac tat       1104
Gly Lys Lys Lys Ser Leu Asn Thr Gly Ile Ile Thr Val Gln Asn Tyr           
        355                 360                 365                       

ggg tct cat gta cct ccc aaa gtc tct cac att act ttt gct cac gaa       1152
Gly Ser His Val Pro Pro Lys Val Ser His Ile Thr Phe Ala His Glu           
    370                 375                 380                           

gtt gga cat aac ttt gga tcc cca cat gat tct gga aca gag tgc aca       1200
Val Gly His Asn Phe Gly Ser Pro His Asp Ser Gly Thr Glu Cys Thr           
385                 390                 395                 400           

cca gga gaa tct aag aat ttg ggt caa aaa gaa aat ggc aat tac atc       1248
Pro Gly Glu Ser Lys Asn Leu Gly Gln Lys Glu Asn Gly Asn Tyr Ile           
                405                 410                 415               

atg tat gca aga gca aca tct ggg gac aaa ctt aac aac aat aaa ttc       1296
Met Tyr Ala Arg Ala Thr Ser Gly Asp Lys Leu Asn Asn Asn Lys Phe           
            420                 425                 430                   

tca ctc tgt agt att aga aat ata agc caa gtt ctt gag aag aag aga       1344
Ser Leu Cys Ser Ile Arg Asn Ile Ser Gln Val Leu Glu Lys Lys Arg           
        435                 440                 445                       

aac aac tgt ttt gtt gaa tct ggc caa cct att tgt gga aat gga atg       1392
Asn Asn Cys Phe Val Glu Ser Gly Gln Pro Ile Cys Gly Asn Gly Met           
    450                 455                 460                           

gta gaa caa ggt gaa gaa tgt gat tgt ggc tat agt gac cag tgt aaa       1440
Val Glu Gln Gly Glu Glu Cys Asp Cys Gly Tyr Ser Asp Gln Cys Lys           
465                 470                 475                 480           

gat gaa tgc tgc ttc gat gca aat caa cca gag gga aga aaa tgc aaa       1488
Asp Glu Cys Cys Phe Asp Ala Asn Gln Pro Glu Gly Arg Lys Cys Lys           
                485                 490                 495               

ctg aaa cct ggg aaa cag tgc agt cca agt caa ggt cct tgt tgt aca       1536
Leu Lys Pro Gly Lys Gln Cys Ser Pro Ser Gln Gly Pro Cys Cys Thr           
            500                 505                 510                   

gca cag tgt gca ttc aag tca aag tct gag aag tgt cgg gat gat tca       1584
Ala Gln Cys Ala Phe Lys Ser Lys Ser Glu Lys Cys Arg Asp Asp Ser           
        515                 520                 525                       

gac tgt gca agg gaa gga ata tgt aat ggc ttc aca gct ctc tgc cca       1632
Asp Cys Ala Arg Glu Gly Ile Cys Asn Gly Phe Thr Ala Leu Cys Pro           
    530                 535                 540                           

gca tct gac cct aaa cca aac ttc aca gac tgt aat agg cat aca caa       1680
Ala Ser Asp Pro Lys Pro Asn Phe Thr Asp Cys Asn Arg His Thr Gln           
545                 550                 555                 560           

gtg tgc att aat ggg caa tgt gca ggt tct atc tgt gag aaa tat ggc       1728
Val Cys Ile Asn Gly Gln Cys Ala Gly Ser Ile Cys Glu Lys Tyr Gly           
                565                 570                 575               

tta gag gag tgt acg tgt gcc agt tct gat ggc aaa gat gat aaa gaa       1776
Leu Glu Glu Cys Thr Cys Ala Ser Ser Asp Gly Lys Asp Asp Lys Glu           
            580                 585                 590                   

tta tgc cat gta tgc tgt atg aag aaa atg gac cca tca act tgt gcc       1824
Leu Cys His Val Cys Cys Met Lys Lys Met Asp Pro Ser Thr Cys Ala           
        595                 600                 605                       

agt aca ggg tct gtg cag tgg agt agg cac ttc agt ggt cga acc atc       1872
Ser Thr Gly Ser Val Gln Trp Ser Arg His Phe Ser Gly Arg Thr Ile           
    610                 615                 620                           

acc ctg caa cct gga tcc cct tgc aac gat ttt aga ggt tac tgt gat       1920
Thr Leu Gln Pro Gly Ser Pro Cys Asn Asp Phe Arg Gly Tyr Cys Asp           
625                 630                 635                 640           

gtt ttc atg cgg tgc aga tta gta gat gct gat ggt cct cta gct agg       1968
Val Phe Met Arg Cys Arg Leu Val Asp Ala Asp Gly Pro Leu Ala Arg           
                645                 650                 655               

ctt aaa aaa gca att ttt agt cca gag ctc tat gaa aac att gct gaa       2016
Leu Lys Lys Ala Ile Phe Ser Pro Glu Leu Tyr Glu Asn Ile Ala Glu           
            660                 665                 670                   

tgg att gtg gct cat tgg tgg gca gta tta ctt atg gga att gct ctg       2064
Trp Ile Val Ala His Trp Trp Ala Val Leu Leu Met Gly Ile Ala Leu           
        675                 680                 685                       

atc atg cta atg gct gga ttt att aag ata tgc agt gtt cat act cca       2112
Ile Met Leu Met Ala Gly Phe Ile Lys Ile Cys Ser Val His Thr Pro           
    690                 695                 700                           

agt agt aat cca aag ttg cct cct cct aaa cca ctt cca ggc act tta       2160
Ser Ser Asn Pro Lys Leu Pro Pro Pro Lys Pro Leu Pro Gly Thr Leu           
705                 710                 715                 720           

aag agg agg aga cct cca cag ccc att cag caa ccc cag cgt cag cgg       2208
Lys Arg Arg Arg Pro Pro Gln Pro Ile Gln Gln Pro Gln Arg Gln Arg           
                725                 730                 735               

ccc cga gag agt tat caa atg gga cac atg aga cgc taa                   2247
Pro Arg Glu Ser Tyr Gln Met Gly His Met Arg Arg                           
            740                 745                                       


<210>  2
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Leu Leu Arg Val Leu Ile Leu Leu Leu Ser Trp Ala Ala Gly 
1               5                   10                  15      


Met Gly Gly Gln Tyr Gly Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr 
            20                  25                  30          


Glu Gly Leu Ser Tyr Asn Val Asp Ser Leu His Gln Lys His Gln Arg 
        35                  40                  45              


Ala Lys Arg Ala Val Ser His Glu Asp Gln Phe Leu Arg Leu Asp Phe 
    50                  55                  60                  


His Ala His Gly Arg His Phe Asn Leu Arg Met Lys Arg Asp Thr Ser 
65                  70                  75                  80  


Leu Phe Ser Asp Glu Phe Lys Val Glu Thr Ser Asn Lys Val Leu Asp 
                85                  90                  95      


Tyr Asp Thr Ser His Ile Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly 
            100                 105                 110         


Ser Phe Ser His Gly Ser Val Ile Asp Gly Arg Phe Glu Gly Phe Ile 
        115                 120                 125             


Gln Thr Arg Gly Gly Thr Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile 
    130                 135                 140                 


Lys Asp Arg Thr Leu Pro Phe His Ser Val Ile Tyr His Glu Asp Asp 
145                 150                 155                 160 


Ile Asn Tyr Pro His Lys Tyr Gly Pro Gln Gly Gly Cys Ala Asp His 
                165                 170                 175     


Ser Val Phe Glu Arg Met Arg Lys Tyr Gln Met Thr Gly Val Glu Glu 
            180                 185                 190         


Val Thr Gln Ile Pro Gln Glu Glu His Ala Ala Asn Gly Pro Glu Leu 
        195                 200                 205             


Leu Arg Lys Lys Arg Thr Thr Ser Ala Glu Lys Asn Thr Cys Gln Leu 
    210                 215                 220                 


Tyr Ile Gln Thr Asp His Leu Phe Phe Lys Tyr Tyr Gly Thr Arg Glu 
225                 230                 235                 240 


Ala Val Ile Ala Gln Ile Ser Ser His Val Lys Ala Ile Asp Thr Ile 
                245                 250                 255     


Tyr Gln Thr Thr Asp Phe Ser Gly Ile Arg Asn Ile Ser Phe Met Val 
            260                 265                 270         


Lys Arg Ile Arg Ile Asn Thr Thr Ala Asp Glu Lys Asp Pro Thr Asn 
        275                 280                 285             


Pro Phe Arg Phe Pro Asn Ile Gly Val Glu Lys Phe Leu Glu Leu Asn 
    290                 295                 300                 


Ser Glu Gln Asn His Asp Asp Tyr Cys Leu Ala Tyr Val Phe Thr Asp 
305                 310                 315                 320 


Arg Asp Phe Asp Asp Gly Val Leu Gly Leu Ala Trp Val Gly Ala Pro 
                325                 330                 335     


Ser Gly Ser Ser Gly Gly Ile Cys Glu Lys Ser Lys Leu Tyr Ser Asp 
            340                 345                 350         


Gly Lys Lys Lys Ser Leu Asn Thr Gly Ile Ile Thr Val Gln Asn Tyr 
        355                 360                 365             


Gly Ser His Val Pro Pro Lys Val Ser His Ile Thr Phe Ala His Glu 
    370                 375                 380                 


Val Gly His Asn Phe Gly Ser Pro His Asp Ser Gly Thr Glu Cys Thr 
385                 390                 395                 400 


Pro Gly Glu Ser Lys Asn Leu Gly Gln Lys Glu Asn Gly Asn Tyr Ile 
                405                 410                 415     


Met Tyr Ala Arg Ala Thr Ser Gly Asp Lys Leu Asn Asn Asn Lys Phe 
            420                 425                 430         


Ser Leu Cys Ser Ile Arg Asn Ile Ser Gln Val Leu Glu Lys Lys Arg 
        435                 440                 445             


Asn Asn Cys Phe Val Glu Ser Gly Gln Pro Ile Cys Gly Asn Gly Met 
    450                 455                 460                 


Val Glu Gln Gly Glu Glu Cys Asp Cys Gly Tyr Ser Asp Gln Cys Lys 
465                 470                 475                 480 


Asp Glu Cys Cys Phe Asp Ala Asn Gln Pro Glu Gly Arg Lys Cys Lys 
                485                 490                 495     


Leu Lys Pro Gly Lys Gln Cys Ser Pro Ser Gln Gly Pro Cys Cys Thr 
            500                 505                 510         


Ala Gln Cys Ala Phe Lys Ser Lys Ser Glu Lys Cys Arg Asp Asp Ser 
        515                 520                 525             


Asp Cys Ala Arg Glu Gly Ile Cys Asn Gly Phe Thr Ala Leu Cys Pro 
    530                 535                 540                 


Ala Ser Asp Pro Lys Pro Asn Phe Thr Asp Cys Asn Arg His Thr Gln 
545                 550                 555                 560 


Val Cys Ile Asn Gly Gln Cys Ala Gly Ser Ile Cys Glu Lys Tyr Gly 
                565                 570                 575     


Leu Glu Glu Cys Thr Cys Ala Ser Ser Asp Gly Lys Asp Asp Lys Glu 
            580                 585                 590         


Leu Cys His Val Cys Cys Met Lys Lys Met Asp Pro Ser Thr Cys Ala 
        595                 600                 605             


Ser Thr Gly Ser Val Gln Trp Ser Arg His Phe Ser Gly Arg Thr Ile 
    610                 615                 620                 


Thr Leu Gln Pro Gly Ser Pro Cys Asn Asp Phe Arg Gly Tyr Cys Asp 
625                 630                 635                 640 


Val Phe Met Arg Cys Arg Leu Val Asp Ala Asp Gly Pro Leu Ala Arg 
                645                 650                 655     


Leu Lys Lys Ala Ile Phe Ser Pro Glu Leu Tyr Glu Asn Ile Ala Glu 
            660                 665                 670         


Trp Ile Val Ala His Trp Trp Ala Val Leu Leu Met Gly Ile Ala Leu 
        675                 680                 685             


Ile Met Leu Met Ala Gly Phe Ile Lys Ile Cys Ser Val His Thr Pro 
    690                 695                 700                 


Ser Ser Asn Pro Lys Leu Pro Pro Pro Lys Pro Leu Pro Gly Thr Leu 
705                 710                 715                 720 


Lys Arg Arg Arg Pro Pro Gln Pro Ile Gln Gln Pro Gln Arg Gln Arg 
                725                 730                 735     


Pro Arg Glu Ser Tyr Gln Met Gly His Met Arg Arg 
            740                 745             


<210>  3
<211>  1752
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1752)

<400>  3
atg gaa tcc aag ggg gcc agt tcc tgc cgt ctg ctc ttc tgc ctc ttg         48
Met Glu Ser Lys Gly Ala Ser Ser Cys Arg Leu Leu Phe Cys Leu Leu           
1               5                   10                  15                

atc tcc gcc acc gtc ttc agg cca ggc ctt gga tgg tat act gta aat         96
Ile Ser Ala Thr Val Phe Arg Pro Gly Leu Gly Trp Tyr Thr Val Asn           
            20                  25                  30                    

tca gca tat gga gat acc att atc ata cct tgc cga ctt gac gta cct        144
Ser Ala Tyr Gly Asp Thr Ile Ile Ile Pro Cys Arg Leu Asp Val Pro           
        35                  40                  45                        

cag aat ctc atg ttt ggc aaa tgg aaa tat gaa aag ccc gat ggc tcc        192
Gln Asn Leu Met Phe Gly Lys Trp Lys Tyr Glu Lys Pro Asp Gly Ser           
    50                  55                  60                            

cca gta ttt att gcc ttc aga tcc tct aca aag aaa agt gtg cag tac        240
Pro Val Phe Ile Ala Phe Arg Ser Ser Thr Lys Lys Ser Val Gln Tyr           
65                  70                  75                  80            

gac gat gta cca gaa tac aaa gac aga ttg aac ctc tca gaa aac tac        288
Asp Asp Val Pro Glu Tyr Lys Asp Arg Leu Asn Leu Ser Glu Asn Tyr           
                85                  90                  95                

act ttg tct atc agt aat gca agg atc agt gat gaa aag aga ttt gtg        336
Thr Leu Ser Ile Ser Asn Ala Arg Ile Ser Asp Glu Lys Arg Phe Val           
            100                 105                 110                   

tgc atg cta gta act gag gac aac gtg ttt gag gca cct aca ata gtc        384
Cys Met Leu Val Thr Glu Asp Asn Val Phe Glu Ala Pro Thr Ile Val           
        115                 120                 125                       

aag gtg ttc aag caa cca tct aaa cct gaa att gta agc aaa gca ctg        432
Lys Val Phe Lys Gln Pro Ser Lys Pro Glu Ile Val Ser Lys Ala Leu           
    130                 135                 140                           

ttt ctc gaa aca gag cag cta aaa aag ttg ggt gac tgc att tca gaa        480
Phe Leu Glu Thr Glu Gln Leu Lys Lys Leu Gly Asp Cys Ile Ser Glu           
145                 150                 155                 160           

gac agt tat cca gat ggc aat atc aca tgg tac agg aat gga aaa gtg        528
Asp Ser Tyr Pro Asp Gly Asn Ile Thr Trp Tyr Arg Asn Gly Lys Val           
                165                 170                 175               

cta cat ccc ctt gaa gga gcg gtg gtc ata att ttt aaa aag gaa atg        576
Leu His Pro Leu Glu Gly Ala Val Val Ile Ile Phe Lys Lys Glu Met           
            180                 185                 190                   

gac cca gtg act cag ctc tat acc atg act tcc acc ctg gag tac aag        624
Asp Pro Val Thr Gln Leu Tyr Thr Met Thr Ser Thr Leu Glu Tyr Lys           
        195                 200                 205                       

aca acc aag gct gac ata caa atg cca ttc acc tgc tcg gtg aca tat        672
Thr Thr Lys Ala Asp Ile Gln Met Pro Phe Thr Cys Ser Val Thr Tyr           
    210                 215                 220                           

tat gga cca tct ggc cag aaa aca att cat tct gaa cag gca gta ttt        720
Tyr Gly Pro Ser Gly Gln Lys Thr Ile His Ser Glu Gln Ala Val Phe           
225                 230                 235                 240           

gat att tac tat cct aca gag cag gtg aca ata caa gtg ctg cca cca        768
Asp Ile Tyr Tyr Pro Thr Glu Gln Val Thr Ile Gln Val Leu Pro Pro           
                245                 250                 255               

aaa aat gcc atc aaa gaa ggg gat aac atc act ctt aaa tgc tta ggg        816
Lys Asn Ala Ile Lys Glu Gly Asp Asn Ile Thr Leu Lys Cys Leu Gly           
            260                 265                 270                   

aat ggc aac cct ccc cca gag gaa ttt ttg ttt tac tta cca gga cag        864
Asn Gly Asn Pro Pro Pro Glu Glu Phe Leu Phe Tyr Leu Pro Gly Gln           
        275                 280                 285                       

ccc gaa gga ata aga agc tca aat act tac aca ctg acg gat gtg agg        912
Pro Glu Gly Ile Arg Ser Ser Asn Thr Tyr Thr Leu Thr Asp Val Arg           
    290                 295                 300                           

cgc aat gca aca gga gac tac aag tgt tcc ctg ata gac aaa aaa agc        960
Arg Asn Ala Thr Gly Asp Tyr Lys Cys Ser Leu Ile Asp Lys Lys Ser           
305                 310                 315                 320           

atg att gct tca aca gct atc aca gtt cac tat ttg gat ttg tcc tta       1008
Met Ile Ala Ser Thr Ala Ile Thr Val His Tyr Leu Asp Leu Ser Leu           
                325                 330                 335               

aac cca agt gga gaa gtg act aga cag att ggt gat gcc cta ccc gtg       1056
Asn Pro Ser Gly Glu Val Thr Arg Gln Ile Gly Asp Ala Leu Pro Val           
            340                 345                 350                   

tca tgc aca ata tct gct agc agg aat gca act gtg gta tgg atg aaa       1104
Ser Cys Thr Ile Ser Ala Ser Arg Asn Ala Thr Val Val Trp Met Lys           
        355                 360                 365                       

gat aac atc agg ctt cga tct agc ccg tca ttt tct agt ctt cat tat       1152
Asp Asn Ile Arg Leu Arg Ser Ser Pro Ser Phe Ser Ser Leu His Tyr           
    370                 375                 380                           

cag gat gct gga aac tat gtc tgc gaa act gct ctg cag gag gtt gaa       1200
Gln Asp Ala Gly Asn Tyr Val Cys Glu Thr Ala Leu Gln Glu Val Glu           
385                 390                 395                 400           

gga cta aag aaa aga gag tca ttg act ctc att gta gaa ggc aaa cct       1248
Gly Leu Lys Lys Arg Glu Ser Leu Thr Leu Ile Val Glu Gly Lys Pro           
                405                 410                 415               

caa ata aaa atg aca aag aaa act gat ccc agt gga cta tct aaa aca       1296
Gln Ile Lys Met Thr Lys Lys Thr Asp Pro Ser Gly Leu Ser Lys Thr           
            420                 425                 430                   

ata atc tgc cat gtg gaa ggt ttt cca aag cca gcc att caa tgg aca       1344
Ile Ile Cys His Val Glu Gly Phe Pro Lys Pro Ala Ile Gln Trp Thr           
        435                 440                 445                       

att act ggc agt gga agc gtc ata aac caa aca gag gaa tct cct tat       1392
Ile Thr Gly Ser Gly Ser Val Ile Asn Gln Thr Glu Glu Ser Pro Tyr           
    450                 455                 460                           

att aat ggc agg tat tat agt aaa att atc att tcc cct gaa gag aat       1440
Ile Asn Gly Arg Tyr Tyr Ser Lys Ile Ile Ile Ser Pro Glu Glu Asn           
465                 470                 475                 480           

gtt aca tta act tgc aca gca gaa aac caa ctg gag aga aca gta aac       1488
Val Thr Leu Thr Cys Thr Ala Glu Asn Gln Leu Glu Arg Thr Val Asn           
                485                 490                 495               

tcc ttg aat gtc tct gct ata agt att cca gaa cac gat gag gca gac       1536
Ser Leu Asn Val Ser Ala Ile Ser Ile Pro Glu His Asp Glu Ala Asp           
            500                 505                 510                   

gag ata agt gat gaa aac aga gaa aag gtg aat gac cag gca aaa cta       1584
Glu Ile Ser Asp Glu Asn Arg Glu Lys Val Asn Asp Gln Ala Lys Leu           
        515                 520                 525                       

att gtg gga atc gtt gtt ggt ctc ctc ctt gct gcc ctt gtt gct ggt       1632
Ile Val Gly Ile Val Val Gly Leu Leu Leu Ala Ala Leu Val Ala Gly           
    530                 535                 540                           

gtc gtc tac tgg ctg tac atg aag aag tca aag act gca tca aaa cat       1680
Val Val Tyr Trp Leu Tyr Met Lys Lys Ser Lys Thr Ala Ser Lys His           
545                 550                 555                 560           

gta aac aag gac ctc ggt aat atg gaa gaa aac aaa aag tta gaa gaa       1728
Val Asn Lys Asp Leu Gly Asn Met Glu Glu Asn Lys Lys Leu Glu Glu           
                565                 570                 575               

aac aat cac aaa act gaa gcc taa                                       1752
Asn Asn His Lys Thr Glu Ala                                               
            580                                                           


<210>  4
<211>  583
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Ser Lys Gly Ala Ser Ser Cys Arg Leu Leu Phe Cys Leu Leu 
1               5                   10                  15      


Ile Ser Ala Thr Val Phe Arg Pro Gly Leu Gly Trp Tyr Thr Val Asn 
            20                  25                  30          


Ser Ala Tyr Gly Asp Thr Ile Ile Ile Pro Cys Arg Leu Asp Val Pro 
        35                  40                  45              


Gln Asn Leu Met Phe Gly Lys Trp Lys Tyr Glu Lys Pro Asp Gly Ser 
    50                  55                  60                  


Pro Val Phe Ile Ala Phe Arg Ser Ser Thr Lys Lys Ser Val Gln Tyr 
65                  70                  75                  80  


Asp Asp Val Pro Glu Tyr Lys Asp Arg Leu Asn Leu Ser Glu Asn Tyr 
                85                  90                  95      


Thr Leu Ser Ile Ser Asn Ala Arg Ile Ser Asp Glu Lys Arg Phe Val 
            100                 105                 110         


Cys Met Leu Val Thr Glu Asp Asn Val Phe Glu Ala Pro Thr Ile Val 
        115                 120                 125             


Lys Val Phe Lys Gln Pro Ser Lys Pro Glu Ile Val Ser Lys Ala Leu 
    130                 135                 140                 


Phe Leu Glu Thr Glu Gln Leu Lys Lys Leu Gly Asp Cys Ile Ser Glu 
145                 150                 155                 160 


Asp Ser Tyr Pro Asp Gly Asn Ile Thr Trp Tyr Arg Asn Gly Lys Val 
                165                 170                 175     


Leu His Pro Leu Glu Gly Ala Val Val Ile Ile Phe Lys Lys Glu Met 
            180                 185                 190         


Asp Pro Val Thr Gln Leu Tyr Thr Met Thr Ser Thr Leu Glu Tyr Lys 
        195                 200                 205             


Thr Thr Lys Ala Asp Ile Gln Met Pro Phe Thr Cys Ser Val Thr Tyr 
    210                 215                 220                 


Tyr Gly Pro Ser Gly Gln Lys Thr Ile His Ser Glu Gln Ala Val Phe 
225                 230                 235                 240 


Asp Ile Tyr Tyr Pro Thr Glu Gln Val Thr Ile Gln Val Leu Pro Pro 
                245                 250                 255     


Lys Asn Ala Ile Lys Glu Gly Asp Asn Ile Thr Leu Lys Cys Leu Gly 
            260                 265                 270         


Asn Gly Asn Pro Pro Pro Glu Glu Phe Leu Phe Tyr Leu Pro Gly Gln 
        275                 280                 285             


Pro Glu Gly Ile Arg Ser Ser Asn Thr Tyr Thr Leu Thr Asp Val Arg 
    290                 295                 300                 


Arg Asn Ala Thr Gly Asp Tyr Lys Cys Ser Leu Ile Asp Lys Lys Ser 
305                 310                 315                 320 


Met Ile Ala Ser Thr Ala Ile Thr Val His Tyr Leu Asp Leu Ser Leu 
                325                 330                 335     


Asn Pro Ser Gly Glu Val Thr Arg Gln Ile Gly Asp Ala Leu Pro Val 
            340                 345                 350         


Ser Cys Thr Ile Ser Ala Ser Arg Asn Ala Thr Val Val Trp Met Lys 
        355                 360                 365             


Asp Asn Ile Arg Leu Arg Ser Ser Pro Ser Phe Ser Ser Leu His Tyr 
    370                 375                 380                 


Gln Asp Ala Gly Asn Tyr Val Cys Glu Thr Ala Leu Gln Glu Val Glu 
385                 390                 395                 400 


Gly Leu Lys Lys Arg Glu Ser Leu Thr Leu Ile Val Glu Gly Lys Pro 
                405                 410                 415     


Gln Ile Lys Met Thr Lys Lys Thr Asp Pro Ser Gly Leu Ser Lys Thr 
            420                 425                 430         


Ile Ile Cys His Val Glu Gly Phe Pro Lys Pro Ala Ile Gln Trp Thr 
        435                 440                 445             


Ile Thr Gly Ser Gly Ser Val Ile Asn Gln Thr Glu Glu Ser Pro Tyr 
    450                 455                 460                 


Ile Asn Gly Arg Tyr Tyr Ser Lys Ile Ile Ile Ser Pro Glu Glu Asn 
465                 470                 475                 480 


Val Thr Leu Thr Cys Thr Ala Glu Asn Gln Leu Glu Arg Thr Val Asn 
                485                 490                 495     


Ser Leu Asn Val Ser Ala Ile Ser Ile Pro Glu His Asp Glu Ala Asp 
            500                 505                 510         


Glu Ile Ser Asp Glu Asn Arg Glu Lys Val Asn Asp Gln Ala Lys Leu 
        515                 520                 525             


Ile Val Gly Ile Val Val Gly Leu Leu Leu Ala Ala Leu Val Ala Gly 
    530                 535                 540                 


Val Val Tyr Trp Leu Tyr Met Lys Lys Ser Lys Thr Ala Ser Lys His 
545                 550                 555                 560 


Val Asn Lys Asp Leu Gly Asn Met Glu Glu Asn Lys Lys Leu Glu Glu 
                565                 570                 575     


Asn Asn His Lys Thr Glu Ala 
            580             


<210>  5
<211>  1713
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1713)

<400>  5
atg gaa tcc aag ggg gcc agt tcc tgc cgt ctg ctc ttc tgc ctc ttg         48
Met Glu Ser Lys Gly Ala Ser Ser Cys Arg Leu Leu Phe Cys Leu Leu           
1               5                   10                  15                

atc tcc gcc acc gtc ttc agg cca ggc ctt gga tgg tat act gta aat         96
Ile Ser Ala Thr Val Phe Arg Pro Gly Leu Gly Trp Tyr Thr Val Asn           
            20                  25                  30                    

tca gca tat gga gat acc att atc ata cct tgc cga ctt gac gta cct        144
Ser Ala Tyr Gly Asp Thr Ile Ile Ile Pro Cys Arg Leu Asp Val Pro           
        35                  40                  45                        

cag aat ctc atg ttt ggc aaa tgg aaa tat gaa aag ccc gat ggc tcc        192
Gln Asn Leu Met Phe Gly Lys Trp Lys Tyr Glu Lys Pro Asp Gly Ser           
    50                  55                  60                            

cca gta ttt att gcc ttc aga tcc tct aca aag aaa agt gtg cag tac        240
Pro Val Phe Ile Ala Phe Arg Ser Ser Thr Lys Lys Ser Val Gln Tyr           
65                  70                  75                  80            

gac gat gta cca gaa tac aaa gac aga ttg aac ctc tca gaa aac tac        288
Asp Asp Val Pro Glu Tyr Lys Asp Arg Leu Asn Leu Ser Glu Asn Tyr           
                85                  90                  95                

act ttg tct atc agt aat gca agg atc agt gat gaa aag aga ttt gtg        336
Thr Leu Ser Ile Ser Asn Ala Arg Ile Ser Asp Glu Lys Arg Phe Val           
            100                 105                 110                   

tgc atg cta gta act gag gac aac gtg ttt gag gca cct aca ata gtc        384
Cys Met Leu Val Thr Glu Asp Asn Val Phe Glu Ala Pro Thr Ile Val           
        115                 120                 125                       

aag gtg ttc aag caa cca tct aaa cct gaa att gta agc aaa gca ctg        432
Lys Val Phe Lys Gln Pro Ser Lys Pro Glu Ile Val Ser Lys Ala Leu           
    130                 135                 140                           

ttt ctc gaa aca gag cag cta aaa aag ttg ggt gac tgc att tca gaa        480
Phe Leu Glu Thr Glu Gln Leu Lys Lys Leu Gly Asp Cys Ile Ser Glu           
145                 150                 155                 160           

gac agt tat cca gat ggc aat atc aca tgg tac agg aat gga aaa gtg        528
Asp Ser Tyr Pro Asp Gly Asn Ile Thr Trp Tyr Arg Asn Gly Lys Val           
                165                 170                 175               

cta cat ccc ctt gaa gga gcg gtg gtc ata att ttt aaa aag gaa atg        576
Leu His Pro Leu Glu Gly Ala Val Val Ile Ile Phe Lys Lys Glu Met           
            180                 185                 190                   

gac cca gtg act cag ctc tat acc atg act tcc acc ctg gag tac aag        624
Asp Pro Val Thr Gln Leu Tyr Thr Met Thr Ser Thr Leu Glu Tyr Lys           
        195                 200                 205                       

aca acc aag gct gac ata caa atg cca ttc acc tgc tcg gtg aca tat        672
Thr Thr Lys Ala Asp Ile Gln Met Pro Phe Thr Cys Ser Val Thr Tyr           
    210                 215                 220                           

tat gga cca tct ggc cag aaa aca att cat tct gaa cag gca gta ttt        720
Tyr Gly Pro Ser Gly Gln Lys Thr Ile His Ser Glu Gln Ala Val Phe           
225                 230                 235                 240           

gat att tac tat cct aca gag cag gtg aca ata caa gtg ctg cca cca        768
Asp Ile Tyr Tyr Pro Thr Glu Gln Val Thr Ile Gln Val Leu Pro Pro           
                245                 250                 255               

aaa aat gcc atc aaa gaa ggg gat aac atc act ctt aaa tgc tta ggg        816
Lys Asn Ala Ile Lys Glu Gly Asp Asn Ile Thr Leu Lys Cys Leu Gly           
            260                 265                 270                   

aat ggc aac cct ccc cca gag gaa ttt ttg ttt tac tta cca gga cag        864
Asn Gly Asn Pro Pro Pro Glu Glu Phe Leu Phe Tyr Leu Pro Gly Gln           
        275                 280                 285                       

ccc gaa gga ata aga agc tca aat act tac aca ctg acg gat gtg agg        912
Pro Glu Gly Ile Arg Ser Ser Asn Thr Tyr Thr Leu Thr Asp Val Arg           
    290                 295                 300                           

cgc aat gca aca gga gac tac aag tgt tcc ctg ata gac aaa aaa agc        960
Arg Asn Ala Thr Gly Asp Tyr Lys Cys Ser Leu Ile Asp Lys Lys Ser           
305                 310                 315                 320           

atg att gct tca aca gct atc aca gtt cac tat ttg gat ttg tcc tta       1008
Met Ile Ala Ser Thr Ala Ile Thr Val His Tyr Leu Asp Leu Ser Leu           
                325                 330                 335               

aac cca agt gga gaa gtg act aga cag att ggt gat gcc cta ccc gtg       1056
Asn Pro Ser Gly Glu Val Thr Arg Gln Ile Gly Asp Ala Leu Pro Val           
            340                 345                 350                   

tca tgc aca ata tct gct agc agg aat gca act gtg gta tgg atg aaa       1104
Ser Cys Thr Ile Ser Ala Ser Arg Asn Ala Thr Val Val Trp Met Lys           
        355                 360                 365                       

gat aac atc agg ctt cga tct agc ccg tca ttt tct agt ctt cat tat       1152
Asp Asn Ile Arg Leu Arg Ser Ser Pro Ser Phe Ser Ser Leu His Tyr           
    370                 375                 380                           

cag gat gct gga aac tat gtc tgc gaa act gct ctg cag gag gtt gaa       1200
Gln Asp Ala Gly Asn Tyr Val Cys Glu Thr Ala Leu Gln Glu Val Glu           
385                 390                 395                 400           

gga cta aag aaa aga gag tca ttg act ctc att gta gaa ggc aaa cct       1248
Gly Leu Lys Lys Arg Glu Ser Leu Thr Leu Ile Val Glu Gly Lys Pro           
                405                 410                 415               

caa ata aaa atg aca aag aaa act gat ccc agt gga cta tct aaa aca       1296
Gln Ile Lys Met Thr Lys Lys Thr Asp Pro Ser Gly Leu Ser Lys Thr           
            420                 425                 430                   

ata atc tgc cat gtg gaa ggt ttt cca aag cca gcc att caa tgg aca       1344
Ile Ile Cys His Val Glu Gly Phe Pro Lys Pro Ala Ile Gln Trp Thr           
        435                 440                 445                       

att act ggc agt gga agc gtc ata aac caa aca gag gaa tct cct tat       1392
Ile Thr Gly Ser Gly Ser Val Ile Asn Gln Thr Glu Glu Ser Pro Tyr           
    450                 455                 460                           

att aat ggc agg tat tat agt aaa att atc att tcc cct gaa gag aat       1440
Ile Asn Gly Arg Tyr Tyr Ser Lys Ile Ile Ile Ser Pro Glu Glu Asn           
465                 470                 475                 480           

gtt aca tta act tgc aca gca gaa aac caa ctg gag aga aca gta aac       1488
Val Thr Leu Thr Cys Thr Ala Glu Asn Gln Leu Glu Arg Thr Val Asn           
                485                 490                 495               

tcc ttg aat gtc tct gct aat gaa aac aga gaa aag gtg aat gac cag       1536
Ser Leu Asn Val Ser Ala Asn Glu Asn Arg Glu Lys Val Asn Asp Gln           
            500                 505                 510                   

gca aaa cta att gtg gga atc gtt gtt ggt ctc ctc ctt gct gcc ctt       1584
Ala Lys Leu Ile Val Gly Ile Val Val Gly Leu Leu Leu Ala Ala Leu           
        515                 520                 525                       

gtt gct ggt gtc gtc tac tgg ctg tac atg aag aag tca aag act gca       1632
Val Ala Gly Val Val Tyr Trp Leu Tyr Met Lys Lys Ser Lys Thr Ala           
    530                 535                 540                           

tca aaa cat gta aac aag gac ctc ggt aat atg gaa gaa aac aaa aag       1680
Ser Lys His Val Asn Lys Asp Leu Gly Asn Met Glu Glu Asn Lys Lys           
545                 550                 555                 560           

tta gaa gaa aac aat cac aaa act gaa gcc taa                           1713
Leu Glu Glu Asn Asn His Lys Thr Glu Ala                                   
                565                 570                                   


<210>  6
<211>  570
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Ser Lys Gly Ala Ser Ser Cys Arg Leu Leu Phe Cys Leu Leu 
1               5                   10                  15      


Ile Ser Ala Thr Val Phe Arg Pro Gly Leu Gly Trp Tyr Thr Val Asn 
            20                  25                  30          


Ser Ala Tyr Gly Asp Thr Ile Ile Ile Pro Cys Arg Leu Asp Val Pro 
        35                  40                  45              


Gln Asn Leu Met Phe Gly Lys Trp Lys Tyr Glu Lys Pro Asp Gly Ser 
    50                  55                  60                  


Pro Val Phe Ile Ala Phe Arg Ser Ser Thr Lys Lys Ser Val Gln Tyr 
65                  70                  75                  80  


Asp Asp Val Pro Glu Tyr Lys Asp Arg Leu Asn Leu Ser Glu Asn Tyr 
                85                  90                  95      


Thr Leu Ser Ile Ser Asn Ala Arg Ile Ser Asp Glu Lys Arg Phe Val 
            100                 105                 110         


Cys Met Leu Val Thr Glu Asp Asn Val Phe Glu Ala Pro Thr Ile Val 
        115                 120                 125             


Lys Val Phe Lys Gln Pro Ser Lys Pro Glu Ile Val Ser Lys Ala Leu 
    130                 135                 140                 


Phe Leu Glu Thr Glu Gln Leu Lys Lys Leu Gly Asp Cys Ile Ser Glu 
145                 150                 155                 160 


Asp Ser Tyr Pro Asp Gly Asn Ile Thr Trp Tyr Arg Asn Gly Lys Val 
                165                 170                 175     


Leu His Pro Leu Glu Gly Ala Val Val Ile Ile Phe Lys Lys Glu Met 
            180                 185                 190         


Asp Pro Val Thr Gln Leu Tyr Thr Met Thr Ser Thr Leu Glu Tyr Lys 
        195                 200                 205             


Thr Thr Lys Ala Asp Ile Gln Met Pro Phe Thr Cys Ser Val Thr Tyr 
    210                 215                 220                 


Tyr Gly Pro Ser Gly Gln Lys Thr Ile His Ser Glu Gln Ala Val Phe 
225                 230                 235                 240 


Asp Ile Tyr Tyr Pro Thr Glu Gln Val Thr Ile Gln Val Leu Pro Pro 
                245                 250                 255     


Lys Asn Ala Ile Lys Glu Gly Asp Asn Ile Thr Leu Lys Cys Leu Gly 
            260                 265                 270         


Asn Gly Asn Pro Pro Pro Glu Glu Phe Leu Phe Tyr Leu Pro Gly Gln 
        275                 280                 285             


Pro Glu Gly Ile Arg Ser Ser Asn Thr Tyr Thr Leu Thr Asp Val Arg 
    290                 295                 300                 


Arg Asn Ala Thr Gly Asp Tyr Lys Cys Ser Leu Ile Asp Lys Lys Ser 
305                 310                 315                 320 


Met Ile Ala Ser Thr Ala Ile Thr Val His Tyr Leu Asp Leu Ser Leu 
                325                 330                 335     


Asn Pro Ser Gly Glu Val Thr Arg Gln Ile Gly Asp Ala Leu Pro Val 
            340                 345                 350         


Ser Cys Thr Ile Ser Ala Ser Arg Asn Ala Thr Val Val Trp Met Lys 
        355                 360                 365             


Asp Asn Ile Arg Leu Arg Ser Ser Pro Ser Phe Ser Ser Leu His Tyr 
    370                 375                 380                 


Gln Asp Ala Gly Asn Tyr Val Cys Glu Thr Ala Leu Gln Glu Val Glu 
385                 390                 395                 400 


Gly Leu Lys Lys Arg Glu Ser Leu Thr Leu Ile Val Glu Gly Lys Pro 
                405                 410                 415     


Gln Ile Lys Met Thr Lys Lys Thr Asp Pro Ser Gly Leu Ser Lys Thr 
            420                 425                 430         


Ile Ile Cys His Val Glu Gly Phe Pro Lys Pro Ala Ile Gln Trp Thr 
        435                 440                 445             


Ile Thr Gly Ser Gly Ser Val Ile Asn Gln Thr Glu Glu Ser Pro Tyr 
    450                 455                 460                 


Ile Asn Gly Arg Tyr Tyr Ser Lys Ile Ile Ile Ser Pro Glu Glu Asn 
465                 470                 475                 480 


Val Thr Leu Thr Cys Thr Ala Glu Asn Gln Leu Glu Arg Thr Val Asn 
                485                 490                 495     


Ser Leu Asn Val Ser Ala Asn Glu Asn Arg Glu Lys Val Asn Asp Gln 
            500                 505                 510         


Ala Lys Leu Ile Val Gly Ile Val Val Gly Leu Leu Leu Ala Ala Leu 
        515                 520                 525             


Val Ala Gly Val Val Tyr Trp Leu Tyr Met Lys Lys Ser Lys Thr Ala 
    530                 535                 540                 


Ser Lys His Val Asn Lys Asp Leu Gly Asn Met Glu Glu Asn Lys Lys 
545                 550                 555                 560 


Leu Glu Glu Asn Asn His Lys Thr Glu Ala 
                565                 570 


<210>  7
<211>  2916
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(2916)

<400>  7
atg ctg cgc cgc ccc gct ccc gcg ctg gcc ccg gcc gcc cgg ctg ctg         48
Met Leu Arg Arg Pro Ala Pro Ala Leu Ala Pro Ala Ala Arg Leu Leu           
1               5                   10                  15                

ctg gcc ggg ctg ctg tgc ggc ggc ggg gtc tgg gcc gcg cga gtt aac         96
Leu Ala Gly Leu Leu Cys Gly Gly Gly Val Trp Ala Ala Arg Val Asn           
            20                  25                  30                    

aag cac aag ccc tgg ctg gag ccc acc tac cac ggc ata gtc aca gag        144
Lys His Lys Pro Trp Leu Glu Pro Thr Tyr His Gly Ile Val Thr Glu           
        35                  40                  45                        

aac gac aac acc gtg ctc ctc gac ccc cca ctg atc gcg ctg gat aaa        192
Asn Asp Asn Thr Val Leu Leu Asp Pro Pro Leu Ile Ala Leu Asp Lys           
    50                  55                  60                            

gat gcg cct ctg cga ttt gca ggt gag att tgt gga ttt aaa att cac        240
Asp Ala Pro Leu Arg Phe Ala Gly Glu Ile Cys Gly Phe Lys Ile His           
65                  70                  75                  80            

ggg cag aat gtc ccc ttt gat gca gtg gta gtg gat aaa tcc act ggt        288
Gly Gln Asn Val Pro Phe Asp Ala Val Val Val Asp Lys Ser Thr Gly           
                85                  90                  95                

gag gga gtc att cgc tcc aaa gag aaa ctg gac tgt gag ctg cag aaa        336
Glu Gly Val Ile Arg Ser Lys Glu Lys Leu Asp Cys Glu Leu Gln Lys           
            100                 105                 110                   

gac tat tca ttc acc atc cag gcc tat gat tgt ggg aag gga cct gat        384
Asp Tyr Ser Phe Thr Ile Gln Ala Tyr Asp Cys Gly Lys Gly Pro Asp           
        115                 120                 125                       

ggc acc aac gtg aaa aag tct cat aaa gca act gtt cat att cag gtg        432
Gly Thr Asn Val Lys Lys Ser His Lys Ala Thr Val His Ile Gln Val           
    130                 135                 140                           

aac gac gtg aat gag tac gcg ccc gtg ttc aag gag aag tcc tac aaa        480
Asn Asp Val Asn Glu Tyr Ala Pro Val Phe Lys Glu Lys Ser Tyr Lys           
145                 150                 155                 160           

gcc acg gtc atc gag ggg aag cag tac gac agc att ttg agg gtg gag        528
Ala Thr Val Ile Glu Gly Lys Gln Tyr Asp Ser Ile Leu Arg Val Glu           
                165                 170                 175               

gcc gtg gat gcc gac tgc tcc cct cag ttc agc cag att tgc agc tac        576
Ala Val Asp Ala Asp Cys Ser Pro Gln Phe Ser Gln Ile Cys Ser Tyr           
            180                 185                 190                   

gaa atc atc act cca gac gtg ccc ttt act gtt gac aaa gat ggt tat        624
Glu Ile Ile Thr Pro Asp Val Pro Phe Thr Val Asp Lys Asp Gly Tyr           
        195                 200                 205                       

ata aaa aac aca gag aaa tta aac tac ggg aaa gaa cat caa tat aag        672
Ile Lys Asn Thr Glu Lys Leu Asn Tyr Gly Lys Glu His Gln Tyr Lys           
    210                 215                 220                           

ctg acc gtc act gcc tat gac tgt ggg aag aaa aga gcc aca gaa gat        720
Leu Thr Val Thr Ala Tyr Asp Cys Gly Lys Lys Arg Ala Thr Glu Asp           
225                 230                 235                 240           

gtt ttg gtg aag atc agc att aag ccc acc tgc acc cct ggg tgg caa        768
Val Leu Val Lys Ile Ser Ile Lys Pro Thr Cys Thr Pro Gly Trp Gln           
                245                 250                 255               

gga tgg aac aac agg att gag tat gag ccg ggc acc ggc gcg ttg gcc        816
Gly Trp Asn Asn Arg Ile Glu Tyr Glu Pro Gly Thr Gly Ala Leu Ala           
            260                 265                 270                   

gtc ttt cca aat atc cac ctg gag aca tgt gac gag cca gtc gcc tca        864
Val Phe Pro Asn Ile His Leu Glu Thr Cys Asp Glu Pro Val Ala Ser           
        275                 280                 285                       

gta cag gcc aca gtg gag cta gaa acc agc cac ata ggg aaa ggc tgc        912
Val Gln Ala Thr Val Glu Leu Glu Thr Ser His Ile Gly Lys Gly Cys           
    290                 295                 300                           

gac cga gac acc tac tca gag aag tcc ctc cac cgg ctc tgt ggt gcg        960
Asp Arg Asp Thr Tyr Ser Glu Lys Ser Leu His Arg Leu Cys Gly Ala           
305                 310                 315                 320           

gcc gcg ggc act gcc gag ctg ctg cca tcc ccg agt gga tcc ctc aac       1008
Ala Ala Gly Thr Ala Glu Leu Leu Pro Ser Pro Ser Gly Ser Leu Asn           
                325                 330                 335               

tgg acc atg ggc ctg ccc acc gac aat ggc cac gac agc gac cag gtg       1056
Trp Thr Met Gly Leu Pro Thr Asp Asn Gly His Asp Ser Asp Gln Val           
            340                 345                 350                   

ttt gag ttc aac ggc acc cag gca gtg agg atc ccg gat ggc gtc gtg       1104
Phe Glu Phe Asn Gly Thr Gln Ala Val Arg Ile Pro Asp Gly Val Val           
        355                 360                 365                       

tcg gtc agc ccc aaa gag ccg ttc acc atc tcg gtg tgg atg aga cat       1152
Ser Val Ser Pro Lys Glu Pro Phe Thr Ile Ser Val Trp Met Arg His           
    370                 375                 380                           

ggg cca ttc ggc agg aag aag gag aca att ctt tgc agt tct gat aaa       1200
Gly Pro Phe Gly Arg Lys Lys Glu Thr Ile Leu Cys Ser Ser Asp Lys           
385                 390                 395                 400           

aca gat atg aat cgg cac cac tac tcc ctc tat gtc cac ggg tgc cgg       1248
Thr Asp Met Asn Arg His His Tyr Ser Leu Tyr Val His Gly Cys Arg           
                405                 410                 415               

ctg atc ttc ctc ttc cgt cag gat cct tct gag gag aag aaa tac aga       1296
Leu Ile Phe Leu Phe Arg Gln Asp Pro Ser Glu Glu Lys Lys Tyr Arg           
            420                 425                 430                   

cct gca gag ttc cac tgg aag ttg aat cag gtc tgt gat gag gaa tgg       1344
Pro Ala Glu Phe His Trp Lys Leu Asn Gln Val Cys Asp Glu Glu Trp           
        435                 440                 445                       

cac cac tac gtc ctc aat gta gaa ttc ccg agt gtg act ctc tat gtg       1392
His His Tyr Val Leu Asn Val Glu Phe Pro Ser Val Thr Leu Tyr Val           
    450                 455                 460                           

gat ggc acg tcc cac gag ccc ttc tct gtg act gag gat tac ccg ctc       1440
Asp Gly Thr Ser His Glu Pro Phe Ser Val Thr Glu Asp Tyr Pro Leu           
465                 470                 475                 480           

cat cca tcc aag ata gaa act cag ctc gtg gtg ggg gct tgc tgg caa       1488
His Pro Ser Lys Ile Glu Thr Gln Leu Val Val Gly Ala Cys Trp Gln           
                485                 490                 495               

gag ttt tca gga gtt gaa aat gac aat gaa act gag cct gtg act gtg       1536
Glu Phe Ser Gly Val Glu Asn Asp Asn Glu Thr Glu Pro Val Thr Val           
            500                 505                 510                   

gcc tct gca ggt ggc gac ctg cac atg acc cag ttt ttc cga ggc aat       1584
Ala Ser Ala Gly Gly Asp Leu His Met Thr Gln Phe Phe Arg Gly Asn           
        515                 520                 525                       

ctg gct ggc tta act ctc cgt tcc ggg aaa ctc gcg gat aag aag gtg       1632
Leu Ala Gly Leu Thr Leu Arg Ser Gly Lys Leu Ala Asp Lys Lys Val           
    530                 535                 540                           

atc gac tgt ctg tat acc tgc aag gag ggg ctg gac ctg cag gtc ctc       1680
Ile Asp Cys Leu Tyr Thr Cys Lys Glu Gly Leu Asp Leu Gln Val Leu           
545                 550                 555                 560           

gaa gac agt ggc aga ggc gtg cag atc caa gca cac ccc agc cag ttg       1728
Glu Asp Ser Gly Arg Gly Val Gln Ile Gln Ala His Pro Ser Gln Leu           
                565                 570                 575               

gta ttg acc ttg gag gga gaa gac ctc ggg gaa ttg gat aag gcc atg       1776
Val Leu Thr Leu Glu Gly Glu Asp Leu Gly Glu Leu Asp Lys Ala Met           
            580                 585                 590                   

cag cac atc tcg tac ctg aac tcc cgg cag ttc ccc acg ccc gga att       1824
Gln His Ile Ser Tyr Leu Asn Ser Arg Gln Phe Pro Thr Pro Gly Ile           
        595                 600                 605                       

cgc aga ctc aaa atc acc agc aca atc aag tgt ttt aac gag gcc acc       1872
Arg Arg Leu Lys Ile Thr Ser Thr Ile Lys Cys Phe Asn Glu Ala Thr           
    610                 615                 620                           

tgc att tcg gtc ccc ccg gta gat ggc tac gtg atg gtt tta cag ccc       1920
Cys Ile Ser Val Pro Pro Val Asp Gly Tyr Val Met Val Leu Gln Pro           
625                 630                 635                 640           

gag gag ccc aag atc agc ctg agt ggc gtc cac cat ttt gcc cga gca       1968
Glu Glu Pro Lys Ile Ser Leu Ser Gly Val His His Phe Ala Arg Ala           
                645                 650                 655               

gct tct gaa ttt gaa agc tca gaa ggg gtg ttc ctt ttc cct gag ctt       2016
Ala Ser Glu Phe Glu Ser Ser Glu Gly Val Phe Leu Phe Pro Glu Leu           
            660                 665                 670                   

cgc atc atc agc acc atc acg aga gaa gtg gag cct gaa ggg gac ggg       2064
Arg Ile Ile Ser Thr Ile Thr Arg Glu Val Glu Pro Glu Gly Asp Gly           
        675                 680                 685                       

gct gag gac ccc aca gtt caa gaa tca ctg gtg tcc gag gag atc gtg       2112
Ala Glu Asp Pro Thr Val Gln Glu Ser Leu Val Ser Glu Glu Ile Val           
    690                 695                 700                           

cac gac ctg gat acc tgt gag gtc acg gtg gag gga gag gag ctg aac       2160
His Asp Leu Asp Thr Cys Glu Val Thr Val Glu Gly Glu Glu Leu Asn           
705                 710                 715                 720           

cac gag cag gag agc ctg gag gtg gac atg gcc cgc ctg cag cag aag       2208
His Glu Gln Glu Ser Leu Glu Val Asp Met Ala Arg Leu Gln Gln Lys           
                725                 730                 735               

ggc att gaa gtg agc agc tct gaa ctg ggc atg acc ttc aca ggc gtg       2256
Gly Ile Glu Val Ser Ser Ser Glu Leu Gly Met Thr Phe Thr Gly Val           
            740                 745                 750                   

gac acc atg gcc agc tac gag gag gtt ttg cac ctg ctg cgc tat cgg       2304
Asp Thr Met Ala Ser Tyr Glu Glu Val Leu His Leu Leu Arg Tyr Arg           
        755                 760                 765                       

aac tgg cat gcc agg tcc ttg ctt gac cgg aag ttt aag ctc atc tgc       2352
Asn Trp His Ala Arg Ser Leu Leu Asp Arg Lys Phe Lys Leu Ile Cys           
    770                 775                 780                           

tca gag ctg aat ggc cgc tac atc agc aac gaa ttt aag gtg gag gtg       2400
Ser Glu Leu Asn Gly Arg Tyr Ile Ser Asn Glu Phe Lys Val Glu Val           
785                 790                 795                 800           

aat gta atc cac acg gcc aac ccc atg gaa cac gcc aac cac atg gct       2448
Asn Val Ile His Thr Ala Asn Pro Met Glu His Ala Asn His Met Ala           
                805                 810                 815               

gcc cag cca cag ttc gtg cac ccg gaa cac cgc tcc ttt gtt gac ctg       2496
Ala Gln Pro Gln Phe Val His Pro Glu His Arg Ser Phe Val Asp Leu           
            820                 825                 830                   

tca ggc cac aac ctg gcc aac ccc cac ccg ttc gca gtc gtc ccc agc       2544
Ser Gly His Asn Leu Ala Asn Pro His Pro Phe Ala Val Val Pro Ser           
        835                 840                 845                       

act gcg aca gtt gtg atc gtg gtg tgc gtc agc ttc ctg gtg ttc atg       2592
Thr Ala Thr Val Val Ile Val Val Cys Val Ser Phe Leu Val Phe Met           
    850                 855                 860                           

att atc ctg ggg gta ttt cgg atc cgg gcc gca cat cgg cgg acc atg       2640
Ile Ile Leu Gly Val Phe Arg Ile Arg Ala Ala His Arg Arg Thr Met           
865                 870                 875                 880           

cgg gat cag gac acc ggg aag gag aac gag atg gac tgg gac gac tct       2688
Arg Asp Gln Asp Thr Gly Lys Glu Asn Glu Met Asp Trp Asp Asp Ser           
                885                 890                 895               

gcc ctg acc atc acc gtc aac ccc atg gag acc tat gag gac cag cac       2736
Ala Leu Thr Ile Thr Val Asn Pro Met Glu Thr Tyr Glu Asp Gln His           
            900                 905                 910                   

agc agt gag gag gag gag gaa gag gaa gag gaa gag gaa agc gag gac       2784
Ser Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Ser Glu Asp           
        915                 920                 925                       

ggc gaa gaa gag gat gac atc acc agc gcc gag tcg gag agc agc gag       2832
Gly Glu Glu Glu Asp Asp Ile Thr Ser Ala Glu Ser Glu Ser Ser Glu           
    930                 935                 940                           

gag gag gag ggg gag cag ggc gac ccc cag aac gca acc cgg cag cag       2880
Glu Glu Glu Gly Glu Gln Gly Asp Pro Gln Asn Ala Thr Arg Gln Gln           
945                 950                 955                 960           

cag ctg gag tgg gat gac tcc acc ctc agc tac tga                       2916
Gln Leu Glu Trp Asp Asp Ser Thr Leu Ser Tyr                               
                965                 970                                   


<210>  8
<211>  971
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Leu Arg Arg Pro Ala Pro Ala Leu Ala Pro Ala Ala Arg Leu Leu 
1               5                   10                  15      


Leu Ala Gly Leu Leu Cys Gly Gly Gly Val Trp Ala Ala Arg Val Asn 
            20                  25                  30          


Lys His Lys Pro Trp Leu Glu Pro Thr Tyr His Gly Ile Val Thr Glu 
        35                  40                  45              


Asn Asp Asn Thr Val Leu Leu Asp Pro Pro Leu Ile Ala Leu Asp Lys 
    50                  55                  60                  


Asp Ala Pro Leu Arg Phe Ala Gly Glu Ile Cys Gly Phe Lys Ile His 
65                  70                  75                  80  


Gly Gln Asn Val Pro Phe Asp Ala Val Val Val Asp Lys Ser Thr Gly 
                85                  90                  95      


Glu Gly Val Ile Arg Ser Lys Glu Lys Leu Asp Cys Glu Leu Gln Lys 
            100                 105                 110         


Asp Tyr Ser Phe Thr Ile Gln Ala Tyr Asp Cys Gly Lys Gly Pro Asp 
        115                 120                 125             


Gly Thr Asn Val Lys Lys Ser His Lys Ala Thr Val His Ile Gln Val 
    130                 135                 140                 


Asn Asp Val Asn Glu Tyr Ala Pro Val Phe Lys Glu Lys Ser Tyr Lys 
145                 150                 155                 160 


Ala Thr Val Ile Glu Gly Lys Gln Tyr Asp Ser Ile Leu Arg Val Glu 
                165                 170                 175     


Ala Val Asp Ala Asp Cys Ser Pro Gln Phe Ser Gln Ile Cys Ser Tyr 
            180                 185                 190         


Glu Ile Ile Thr Pro Asp Val Pro Phe Thr Val Asp Lys Asp Gly Tyr 
        195                 200                 205             


Ile Lys Asn Thr Glu Lys Leu Asn Tyr Gly Lys Glu His Gln Tyr Lys 
    210                 215                 220                 


Leu Thr Val Thr Ala Tyr Asp Cys Gly Lys Lys Arg Ala Thr Glu Asp 
225                 230                 235                 240 


Val Leu Val Lys Ile Ser Ile Lys Pro Thr Cys Thr Pro Gly Trp Gln 
                245                 250                 255     


Gly Trp Asn Asn Arg Ile Glu Tyr Glu Pro Gly Thr Gly Ala Leu Ala 
            260                 265                 270         


Val Phe Pro Asn Ile His Leu Glu Thr Cys Asp Glu Pro Val Ala Ser 
        275                 280                 285             


Val Gln Ala Thr Val Glu Leu Glu Thr Ser His Ile Gly Lys Gly Cys 
    290                 295                 300                 


Asp Arg Asp Thr Tyr Ser Glu Lys Ser Leu His Arg Leu Cys Gly Ala 
305                 310                 315                 320 


Ala Ala Gly Thr Ala Glu Leu Leu Pro Ser Pro Ser Gly Ser Leu Asn 
                325                 330                 335     


Trp Thr Met Gly Leu Pro Thr Asp Asn Gly His Asp Ser Asp Gln Val 
            340                 345                 350         


Phe Glu Phe Asn Gly Thr Gln Ala Val Arg Ile Pro Asp Gly Val Val 
        355                 360                 365             


Ser Val Ser Pro Lys Glu Pro Phe Thr Ile Ser Val Trp Met Arg His 
    370                 375                 380                 


Gly Pro Phe Gly Arg Lys Lys Glu Thr Ile Leu Cys Ser Ser Asp Lys 
385                 390                 395                 400 


Thr Asp Met Asn Arg His His Tyr Ser Leu Tyr Val His Gly Cys Arg 
                405                 410                 415     


Leu Ile Phe Leu Phe Arg Gln Asp Pro Ser Glu Glu Lys Lys Tyr Arg 
            420                 425                 430         


Pro Ala Glu Phe His Trp Lys Leu Asn Gln Val Cys Asp Glu Glu Trp 
        435                 440                 445             


His His Tyr Val Leu Asn Val Glu Phe Pro Ser Val Thr Leu Tyr Val 
    450                 455                 460                 


Asp Gly Thr Ser His Glu Pro Phe Ser Val Thr Glu Asp Tyr Pro Leu 
465                 470                 475                 480 


His Pro Ser Lys Ile Glu Thr Gln Leu Val Val Gly Ala Cys Trp Gln 
                485                 490                 495     


Glu Phe Ser Gly Val Glu Asn Asp Asn Glu Thr Glu Pro Val Thr Val 
            500                 505                 510         


Ala Ser Ala Gly Gly Asp Leu His Met Thr Gln Phe Phe Arg Gly Asn 
        515                 520                 525             


Leu Ala Gly Leu Thr Leu Arg Ser Gly Lys Leu Ala Asp Lys Lys Val 
    530                 535                 540                 


Ile Asp Cys Leu Tyr Thr Cys Lys Glu Gly Leu Asp Leu Gln Val Leu 
545                 550                 555                 560 


Glu Asp Ser Gly Arg Gly Val Gln Ile Gln Ala His Pro Ser Gln Leu 
                565                 570                 575     


Val Leu Thr Leu Glu Gly Glu Asp Leu Gly Glu Leu Asp Lys Ala Met 
            580                 585                 590         


Gln His Ile Ser Tyr Leu Asn Ser Arg Gln Phe Pro Thr Pro Gly Ile 
        595                 600                 605             


Arg Arg Leu Lys Ile Thr Ser Thr Ile Lys Cys Phe Asn Glu Ala Thr 
    610                 615                 620                 


Cys Ile Ser Val Pro Pro Val Asp Gly Tyr Val Met Val Leu Gln Pro 
625                 630                 635                 640 


Glu Glu Pro Lys Ile Ser Leu Ser Gly Val His His Phe Ala Arg Ala 
                645                 650                 655     


Ala Ser Glu Phe Glu Ser Ser Glu Gly Val Phe Leu Phe Pro Glu Leu 
            660                 665                 670         


Arg Ile Ile Ser Thr Ile Thr Arg Glu Val Glu Pro Glu Gly Asp Gly 
        675                 680                 685             


Ala Glu Asp Pro Thr Val Gln Glu Ser Leu Val Ser Glu Glu Ile Val 
    690                 695                 700                 


His Asp Leu Asp Thr Cys Glu Val Thr Val Glu Gly Glu Glu Leu Asn 
705                 710                 715                 720 


His Glu Gln Glu Ser Leu Glu Val Asp Met Ala Arg Leu Gln Gln Lys 
                725                 730                 735     


Gly Ile Glu Val Ser Ser Ser Glu Leu Gly Met Thr Phe Thr Gly Val 
            740                 745                 750         


Asp Thr Met Ala Ser Tyr Glu Glu Val Leu His Leu Leu Arg Tyr Arg 
        755                 760                 765             


Asn Trp His Ala Arg Ser Leu Leu Asp Arg Lys Phe Lys Leu Ile Cys 
    770                 775                 780                 


Ser Glu Leu Asn Gly Arg Tyr Ile Ser Asn Glu Phe Lys Val Glu Val 
785                 790                 795                 800 


Asn Val Ile His Thr Ala Asn Pro Met Glu His Ala Asn His Met Ala 
                805                 810                 815     


Ala Gln Pro Gln Phe Val His Pro Glu His Arg Ser Phe Val Asp Leu 
            820                 825                 830         


Ser Gly His Asn Leu Ala Asn Pro His Pro Phe Ala Val Val Pro Ser 
        835                 840                 845             


Thr Ala Thr Val Val Ile Val Val Cys Val Ser Phe Leu Val Phe Met 
    850                 855                 860                 


Ile Ile Leu Gly Val Phe Arg Ile Arg Ala Ala His Arg Arg Thr Met 
865                 870                 875                 880 


Arg Asp Gln Asp Thr Gly Lys Glu Asn Glu Met Asp Trp Asp Asp Ser 
                885                 890                 895     


Ala Leu Thr Ile Thr Val Asn Pro Met Glu Thr Tyr Glu Asp Gln His 
            900                 905                 910         


Ser Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Ser Glu Asp 
        915                 920                 925             


Gly Glu Glu Glu Asp Asp Ile Thr Ser Ala Glu Ser Glu Ser Ser Glu 
    930                 935                 940                 


Glu Glu Glu Gly Glu Gln Gly Asp Pro Gln Asn Ala Thr Arg Gln Gln 
945                 950                 955                 960 


Gln Leu Glu Trp Asp Asp Ser Thr Leu Ser Tyr 
                965                 970     


<210>  9
<211>  2946
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(2946)

<400>  9
atg ctg cgc cgc ccc gct ccc gcg ctg gcc ccg gcc gcc cgg ctg ctg         48
Met Leu Arg Arg Pro Ala Pro Ala Leu Ala Pro Ala Ala Arg Leu Leu           
1               5                   10                  15                

ctg gcc ggg ctg ctg tgc ggc ggc ggg gtc tgg gcc gcg cga gtt aac         96
Leu Ala Gly Leu Leu Cys Gly Gly Gly Val Trp Ala Ala Arg Val Asn           
            20                  25                  30                    

aag cac aag ccc tgg ctg gag ccc acc tac cac ggc ata gtc aca gag        144
Lys His Lys Pro Trp Leu Glu Pro Thr Tyr His Gly Ile Val Thr Glu           
        35                  40                  45                        

aac gac aac acc gtg ctc ctc gac ccc cca ctg atc gcg ctg gat aaa        192
Asn Asp Asn Thr Val Leu Leu Asp Pro Pro Leu Ile Ala Leu Asp Lys           
    50                  55                  60                            

gat gcg cct ctg cga ttt gca gag agt ttt gag gtg aca gtc acc aaa        240
Asp Ala Pro Leu Arg Phe Ala Glu Ser Phe Glu Val Thr Val Thr Lys           
65                  70                  75                  80            

gaa ggt gag att tgt gga ttt aaa att cac ggg cag aat gtc ccc ttt        288
Glu Gly Glu Ile Cys Gly Phe Lys Ile His Gly Gln Asn Val Pro Phe           
                85                  90                  95                

gat gca gtg gta gtg gat aaa tcc act ggt gag gga gtc att cgc tcc        336
Asp Ala Val Val Val Asp Lys Ser Thr Gly Glu Gly Val Ile Arg Ser           
            100                 105                 110                   

aaa gag aaa ctg gac tgt gag ctg cag aaa gac tat tca ttc acc atc        384
Lys Glu Lys Leu Asp Cys Glu Leu Gln Lys Asp Tyr Ser Phe Thr Ile           
        115                 120                 125                       

cag gcc tat gat tgt ggg aag gga cct gat ggc acc aac gtg aaa aag        432
Gln Ala Tyr Asp Cys Gly Lys Gly Pro Asp Gly Thr Asn Val Lys Lys           
    130                 135                 140                           

tct cat aaa gca act gtt cat att cag gtg aac gac gtg aat gag tac        480
Ser His Lys Ala Thr Val His Ile Gln Val Asn Asp Val Asn Glu Tyr           
145                 150                 155                 160           

gcg ccc gtg ttc aag gag aag tcc tac aaa gcc acg gtc atc gag ggg        528
Ala Pro Val Phe Lys Glu Lys Ser Tyr Lys Ala Thr Val Ile Glu Gly           
                165                 170                 175               

aag cag tac gac agc att ttg agg gtg gag gcc gtg gat gcc gac tgc        576
Lys Gln Tyr Asp Ser Ile Leu Arg Val Glu Ala Val Asp Ala Asp Cys           
            180                 185                 190                   

tcc cct cag ttc agc cag att tgc agc tac gaa atc atc act cca gac        624
Ser Pro Gln Phe Ser Gln Ile Cys Ser Tyr Glu Ile Ile Thr Pro Asp           
        195                 200                 205                       

gtg ccc ttt act gtt gac aaa gat ggt tat ata aaa aac aca gag aaa        672
Val Pro Phe Thr Val Asp Lys Asp Gly Tyr Ile Lys Asn Thr Glu Lys           
    210                 215                 220                           

tta aac tac ggg aaa gaa cat caa tat aag ctg acc gtc act gcc tat        720
Leu Asn Tyr Gly Lys Glu His Gln Tyr Lys Leu Thr Val Thr Ala Tyr           
225                 230                 235                 240           

gac tgt ggg aag aaa aga gcc aca gaa gat gtt ttg gtg aag atc agc        768
Asp Cys Gly Lys Lys Arg Ala Thr Glu Asp Val Leu Val Lys Ile Ser           
                245                 250                 255               

att aag ccc acc tgc acc cct ggg tgg caa gga tgg aac aac agg att        816
Ile Lys Pro Thr Cys Thr Pro Gly Trp Gln Gly Trp Asn Asn Arg Ile           
            260                 265                 270                   

gag tat gag ccg ggc acc ggc gcg ttg gcc gtc ttt cca aat atc cac        864
Glu Tyr Glu Pro Gly Thr Gly Ala Leu Ala Val Phe Pro Asn Ile His           
        275                 280                 285                       

ctg gag aca tgt gac gag cca gtc gcc tca gta cag gcc aca gtg gag        912
Leu Glu Thr Cys Asp Glu Pro Val Ala Ser Val Gln Ala Thr Val Glu           
    290                 295                 300                           

cta gaa acc agc cac ata ggg aaa ggc tgc gac cga gac acc tac tca        960
Leu Glu Thr Ser His Ile Gly Lys Gly Cys Asp Arg Asp Thr Tyr Ser           
305                 310                 315                 320           

gag aag tcc ctc cac cgg ctc tgt ggt gcg gcc gcg ggc act gcc gag       1008
Glu Lys Ser Leu His Arg Leu Cys Gly Ala Ala Ala Gly Thr Ala Glu           
                325                 330                 335               

ctg ctg cca tcc ccg agt gga tcc ctc aac tgg acc atg ggc ctg ccc       1056
Leu Leu Pro Ser Pro Ser Gly Ser Leu Asn Trp Thr Met Gly Leu Pro           
            340                 345                 350                   

acc gac aat ggc cac gac agc gac cag gtg ttt gag ttc aac ggc acc       1104
Thr Asp Asn Gly His Asp Ser Asp Gln Val Phe Glu Phe Asn Gly Thr           
        355                 360                 365                       

cag gca gtg agg atc ccg gat ggc gtc gtg tcg gtc agc ccc aaa gag       1152
Gln Ala Val Arg Ile Pro Asp Gly Val Val Ser Val Ser Pro Lys Glu           
    370                 375                 380                           

ccg ttc acc atc tcg gtg tgg atg aga cat ggg cca ttc ggc agg aag       1200
Pro Phe Thr Ile Ser Val Trp Met Arg His Gly Pro Phe Gly Arg Lys           
385                 390                 395                 400           

aag gag aca att ctt tgc agt tct gat aaa aca gat atg aat cgg cac       1248
Lys Glu Thr Ile Leu Cys Ser Ser Asp Lys Thr Asp Met Asn Arg His           
                405                 410                 415               

cac tac tcc ctc tat gtc cac ggg tgc cgg ctg atc ttc ctc ttc cgt       1296
His Tyr Ser Leu Tyr Val His Gly Cys Arg Leu Ile Phe Leu Phe Arg           
            420                 425                 430                   

cag gat cct tct gag gag aag aaa tac aga cct gca gag ttc cac tgg       1344
Gln Asp Pro Ser Glu Glu Lys Lys Tyr Arg Pro Ala Glu Phe His Trp           
        435                 440                 445                       

aag ttg aat cag gtc tgt gat gag gaa tgg cac cac tac gtc ctc aat       1392
Lys Leu Asn Gln Val Cys Asp Glu Glu Trp His His Tyr Val Leu Asn           
    450                 455                 460                           

gta gaa ttc ccg agt gtg act ctc tat gtg gat ggc acg tcc cac gag       1440
Val Glu Phe Pro Ser Val Thr Leu Tyr Val Asp Gly Thr Ser His Glu           
465                 470                 475                 480           

ccc ttc tct gtg act gag gat tac ccg ctc cat cca tcc aag ata gaa       1488
Pro Phe Ser Val Thr Glu Asp Tyr Pro Leu His Pro Ser Lys Ile Glu           
                485                 490                 495               

act cag ctc gtg gtg ggg gct tgc tgg caa gag ttt tca gga gtt gaa       1536
Thr Gln Leu Val Val Gly Ala Cys Trp Gln Glu Phe Ser Gly Val Glu           
            500                 505                 510                   

aat gac aat gaa act gag cct gtg act gtg gcc tct gca ggt ggc gac       1584
Asn Asp Asn Glu Thr Glu Pro Val Thr Val Ala Ser Ala Gly Gly Asp           
        515                 520                 525                       

ctg cac atg acc cag ttt ttc cga ggc aat ctg gct ggc tta act ctc       1632
Leu His Met Thr Gln Phe Phe Arg Gly Asn Leu Ala Gly Leu Thr Leu           
    530                 535                 540                           

cgt tcc ggg aaa ctc gcg gat aag aag gtg atc gac tgt ctg tat acc       1680
Arg Ser Gly Lys Leu Ala Asp Lys Lys Val Ile Asp Cys Leu Tyr Thr           
545                 550                 555                 560           

tgc aag gag ggg ctg gac ctg cag gtc ctc gaa gac agt ggc aga ggc       1728
Cys Lys Glu Gly Leu Asp Leu Gln Val Leu Glu Asp Ser Gly Arg Gly           
                565                 570                 575               

gtg cag atc caa gca cac ccc agc cag ttg gta ttg acc ttg gag gga       1776
Val Gln Ile Gln Ala His Pro Ser Gln Leu Val Leu Thr Leu Glu Gly           
            580                 585                 590                   

gaa gac ctc ggg gaa ttg gat aag gcc atg cag cac atc tcg tac ctg       1824
Glu Asp Leu Gly Glu Leu Asp Lys Ala Met Gln His Ile Ser Tyr Leu           
        595                 600                 605                       

aac tcc cgg cag ttc ccc acg ccc gga att cgc aga ctc aaa atc acc       1872
Asn Ser Arg Gln Phe Pro Thr Pro Gly Ile Arg Arg Leu Lys Ile Thr           
    610                 615                 620                           

agc aca atc aag tgt ttt aac gag gcc acc tgc att tcg gtc ccc ccg       1920
Ser Thr Ile Lys Cys Phe Asn Glu Ala Thr Cys Ile Ser Val Pro Pro           
625                 630                 635                 640           

gta gat ggc tac gtg atg gtt tta cag ccc gag gag ccc aag atc agc       1968
Val Asp Gly Tyr Val Met Val Leu Gln Pro Glu Glu Pro Lys Ile Ser           
                645                 650                 655               

ctg agt ggc gtc cac cat ttt gcc cga gca gct tct gaa ttt gaa agc       2016
Leu Ser Gly Val His His Phe Ala Arg Ala Ala Ser Glu Phe Glu Ser           
            660                 665                 670                   

tca gaa ggg gtg ttc ctt ttc cct gag ctt cgc atc atc agc acc atc       2064
Ser Glu Gly Val Phe Leu Phe Pro Glu Leu Arg Ile Ile Ser Thr Ile           
        675                 680                 685                       

acg aga gaa gtg gag cct gaa ggg gac ggg gct gag gac ccc aca gtt       2112
Thr Arg Glu Val Glu Pro Glu Gly Asp Gly Ala Glu Asp Pro Thr Val           
    690                 695                 700                           

caa gaa tca ctg gtg tcc gag gag atc gtg cac gac ctg gat acc tgt       2160
Gln Glu Ser Leu Val Ser Glu Glu Ile Val His Asp Leu Asp Thr Cys           
705                 710                 715                 720           

gag gtc acg gtg gag gga gag gag ctg aac cac gag cag gag agc ctg       2208
Glu Val Thr Val Glu Gly Glu Glu Leu Asn His Glu Gln Glu Ser Leu           
                725                 730                 735               

gag gtg gac atg gcc cgc ctg cag cag aag ggc att gaa gtg agc agc       2256
Glu Val Asp Met Ala Arg Leu Gln Gln Lys Gly Ile Glu Val Ser Ser           
            740                 745                 750                   

tct gaa ctg ggc atg acc ttc aca ggc gtg gac acc atg gcc agc tac       2304
Ser Glu Leu Gly Met Thr Phe Thr Gly Val Asp Thr Met Ala Ser Tyr           
        755                 760                 765                       

gag gag gtt ttg cac ctg ctg cgc tat cgg aac tgg cat gcc agg tcc       2352
Glu Glu Val Leu His Leu Leu Arg Tyr Arg Asn Trp His Ala Arg Ser           
    770                 775                 780                           

ttg ctt gac cgg aag ttt aag ctc atc tgc tca gag ctg aat ggc cgc       2400
Leu Leu Asp Arg Lys Phe Lys Leu Ile Cys Ser Glu Leu Asn Gly Arg           
785                 790                 795                 800           

tac atc agc aac gaa ttt aag gtg gag gtg aat gta atc cac acg gcc       2448
Tyr Ile Ser Asn Glu Phe Lys Val Glu Val Asn Val Ile His Thr Ala           
                805                 810                 815               

aac ccc atg gaa cac gcc aac cac atg gct gcc cag cca cag ttc gtg       2496
Asn Pro Met Glu His Ala Asn His Met Ala Ala Gln Pro Gln Phe Val           
            820                 825                 830                   

cac ccg gaa cac cgc tcc ttt gtt gac ctg tca ggc cac aac ctg gcc       2544
His Pro Glu His Arg Ser Phe Val Asp Leu Ser Gly His Asn Leu Ala           
        835                 840                 845                       

aac ccc cac ccg ttc gca gtc gtc ccc agc act gcg aca gtt gtg atc       2592
Asn Pro His Pro Phe Ala Val Val Pro Ser Thr Ala Thr Val Val Ile           
    850                 855                 860                           

gtg gtg tgc gtc agc ttc ctg gtg ttc atg att atc ctg ggg gta ttt       2640
Val Val Cys Val Ser Phe Leu Val Phe Met Ile Ile Leu Gly Val Phe           
865                 870                 875                 880           

cgg atc cgg gcc gca cat cgg cgg acc atg cgg gat cag gac acc ggg       2688
Arg Ile Arg Ala Ala His Arg Arg Thr Met Arg Asp Gln Asp Thr Gly           
                885                 890                 895               

aag gag aac gag atg gac tgg gac gac tct gcc ctg acc atc acc gtc       2736
Lys Glu Asn Glu Met Asp Trp Asp Asp Ser Ala Leu Thr Ile Thr Val           
            900                 905                 910                   

aac ccc atg gag acc tat gag gac cag cac agc agt gag gag gag gag       2784
Asn Pro Met Glu Thr Tyr Glu Asp Gln His Ser Ser Glu Glu Glu Glu           
        915                 920                 925                       

gaa gag gaa gag gaa gag gaa agc gag gac ggc gaa gaa gag gat gac       2832
Glu Glu Glu Glu Glu Glu Glu Ser Glu Asp Gly Glu Glu Glu Asp Asp           
    930                 935                 940                           

atc acc agc gcc gag tcg gag agc agc gag gag gag gag ggg gag cag       2880
Ile Thr Ser Ala Glu Ser Glu Ser Ser Glu Glu Glu Glu Gly Glu Gln           
945                 950                 955                 960           

ggc gac ccc cag aac gca acc cgg cag cag cag ctg gag tgg gat gac       2928
Gly Asp Pro Gln Asn Ala Thr Arg Gln Gln Gln Leu Glu Trp Asp Asp           
                965                 970                 975               

tcc acc ctc agc tac tga                                               2946
Ser Thr Leu Ser Tyr                                                       
            980                                                           


<210>  10
<211>  981
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Leu Arg Arg Pro Ala Pro Ala Leu Ala Pro Ala Ala Arg Leu Leu 
1               5                   10                  15      


Leu Ala Gly Leu Leu Cys Gly Gly Gly Val Trp Ala Ala Arg Val Asn 
            20                  25                  30          


Lys His Lys Pro Trp Leu Glu Pro Thr Tyr His Gly Ile Val Thr Glu 
        35                  40                  45              


Asn Asp Asn Thr Val Leu Leu Asp Pro Pro Leu Ile Ala Leu Asp Lys 
    50                  55                  60                  


Asp Ala Pro Leu Arg Phe Ala Glu Ser Phe Glu Val Thr Val Thr Lys 
65                  70                  75                  80  


Glu Gly Glu Ile Cys Gly Phe Lys Ile His Gly Gln Asn Val Pro Phe 
                85                  90                  95      


Asp Ala Val Val Val Asp Lys Ser Thr Gly Glu Gly Val Ile Arg Ser 
            100                 105                 110         


Lys Glu Lys Leu Asp Cys Glu Leu Gln Lys Asp Tyr Ser Phe Thr Ile 
        115                 120                 125             


Gln Ala Tyr Asp Cys Gly Lys Gly Pro Asp Gly Thr Asn Val Lys Lys 
    130                 135                 140                 


Ser His Lys Ala Thr Val His Ile Gln Val Asn Asp Val Asn Glu Tyr 
145                 150                 155                 160 


Ala Pro Val Phe Lys Glu Lys Ser Tyr Lys Ala Thr Val Ile Glu Gly 
                165                 170                 175     


Lys Gln Tyr Asp Ser Ile Leu Arg Val Glu Ala Val Asp Ala Asp Cys 
            180                 185                 190         


Ser Pro Gln Phe Ser Gln Ile Cys Ser Tyr Glu Ile Ile Thr Pro Asp 
        195                 200                 205             


Val Pro Phe Thr Val Asp Lys Asp Gly Tyr Ile Lys Asn Thr Glu Lys 
    210                 215                 220                 


Leu Asn Tyr Gly Lys Glu His Gln Tyr Lys Leu Thr Val Thr Ala Tyr 
225                 230                 235                 240 


Asp Cys Gly Lys Lys Arg Ala Thr Glu Asp Val Leu Val Lys Ile Ser 
                245                 250                 255     


Ile Lys Pro Thr Cys Thr Pro Gly Trp Gln Gly Trp Asn Asn Arg Ile 
            260                 265                 270         


Glu Tyr Glu Pro Gly Thr Gly Ala Leu Ala Val Phe Pro Asn Ile His 
        275                 280                 285             


Leu Glu Thr Cys Asp Glu Pro Val Ala Ser Val Gln Ala Thr Val Glu 
    290                 295                 300                 


Leu Glu Thr Ser His Ile Gly Lys Gly Cys Asp Arg Asp Thr Tyr Ser 
305                 310                 315                 320 


Glu Lys Ser Leu His Arg Leu Cys Gly Ala Ala Ala Gly Thr Ala Glu 
                325                 330                 335     


Leu Leu Pro Ser Pro Ser Gly Ser Leu Asn Trp Thr Met Gly Leu Pro 
            340                 345                 350         


Thr Asp Asn Gly His Asp Ser Asp Gln Val Phe Glu Phe Asn Gly Thr 
        355                 360                 365             


Gln Ala Val Arg Ile Pro Asp Gly Val Val Ser Val Ser Pro Lys Glu 
    370                 375                 380                 


Pro Phe Thr Ile Ser Val Trp Met Arg His Gly Pro Phe Gly Arg Lys 
385                 390                 395                 400 


Lys Glu Thr Ile Leu Cys Ser Ser Asp Lys Thr Asp Met Asn Arg His 
                405                 410                 415     


His Tyr Ser Leu Tyr Val His Gly Cys Arg Leu Ile Phe Leu Phe Arg 
            420                 425                 430         


Gln Asp Pro Ser Glu Glu Lys Lys Tyr Arg Pro Ala Glu Phe His Trp 
        435                 440                 445             


Lys Leu Asn Gln Val Cys Asp Glu Glu Trp His His Tyr Val Leu Asn 
    450                 455                 460                 


Val Glu Phe Pro Ser Val Thr Leu Tyr Val Asp Gly Thr Ser His Glu 
465                 470                 475                 480 


Pro Phe Ser Val Thr Glu Asp Tyr Pro Leu His Pro Ser Lys Ile Glu 
                485                 490                 495     


Thr Gln Leu Val Val Gly Ala Cys Trp Gln Glu Phe Ser Gly Val Glu 
            500                 505                 510         


Asn Asp Asn Glu Thr Glu Pro Val Thr Val Ala Ser Ala Gly Gly Asp 
        515                 520                 525             


Leu His Met Thr Gln Phe Phe Arg Gly Asn Leu Ala Gly Leu Thr Leu 
    530                 535                 540                 


Arg Ser Gly Lys Leu Ala Asp Lys Lys Val Ile Asp Cys Leu Tyr Thr 
545                 550                 555                 560 


Cys Lys Glu Gly Leu Asp Leu Gln Val Leu Glu Asp Ser Gly Arg Gly 
                565                 570                 575     


Val Gln Ile Gln Ala His Pro Ser Gln Leu Val Leu Thr Leu Glu Gly 
            580                 585                 590         


Glu Asp Leu Gly Glu Leu Asp Lys Ala Met Gln His Ile Ser Tyr Leu 
        595                 600                 605             


Asn Ser Arg Gln Phe Pro Thr Pro Gly Ile Arg Arg Leu Lys Ile Thr 
    610                 615                 620                 


Ser Thr Ile Lys Cys Phe Asn Glu Ala Thr Cys Ile Ser Val Pro Pro 
625                 630                 635                 640 


Val Asp Gly Tyr Val Met Val Leu Gln Pro Glu Glu Pro Lys Ile Ser 
                645                 650                 655     


Leu Ser Gly Val His His Phe Ala Arg Ala Ala Ser Glu Phe Glu Ser 
            660                 665                 670         


Ser Glu Gly Val Phe Leu Phe Pro Glu Leu Arg Ile Ile Ser Thr Ile 
        675                 680                 685             


Thr Arg Glu Val Glu Pro Glu Gly Asp Gly Ala Glu Asp Pro Thr Val 
    690                 695                 700                 


Gln Glu Ser Leu Val Ser Glu Glu Ile Val His Asp Leu Asp Thr Cys 
705                 710                 715                 720 


Glu Val Thr Val Glu Gly Glu Glu Leu Asn His Glu Gln Glu Ser Leu 
                725                 730                 735     


Glu Val Asp Met Ala Arg Leu Gln Gln Lys Gly Ile Glu Val Ser Ser 
            740                 745                 750         


Ser Glu Leu Gly Met Thr Phe Thr Gly Val Asp Thr Met Ala Ser Tyr 
        755                 760                 765             


Glu Glu Val Leu His Leu Leu Arg Tyr Arg Asn Trp His Ala Arg Ser 
    770                 775                 780                 


Leu Leu Asp Arg Lys Phe Lys Leu Ile Cys Ser Glu Leu Asn Gly Arg 
785                 790                 795                 800 


Tyr Ile Ser Asn Glu Phe Lys Val Glu Val Asn Val Ile His Thr Ala 
                805                 810                 815     


Asn Pro Met Glu His Ala Asn His Met Ala Ala Gln Pro Gln Phe Val 
            820                 825                 830         


His Pro Glu His Arg Ser Phe Val Asp Leu Ser Gly His Asn Leu Ala 
        835                 840                 845             


Asn Pro His Pro Phe Ala Val Val Pro Ser Thr Ala Thr Val Val Ile 
    850                 855                 860                 


Val Val Cys Val Ser Phe Leu Val Phe Met Ile Ile Leu Gly Val Phe 
865                 870                 875                 880 


Arg Ile Arg Ala Ala His Arg Arg Thr Met Arg Asp Gln Asp Thr Gly 
                885                 890                 895     


Lys Glu Asn Glu Met Asp Trp Asp Asp Ser Ala Leu Thr Ile Thr Val 
            900                 905                 910         


Asn Pro Met Glu Thr Tyr Glu Asp Gln His Ser Ser Glu Glu Glu Glu 
        915                 920                 925             


Glu Glu Glu Glu Glu Glu Glu Ser Glu Asp Gly Glu Glu Glu Asp Asp 
    930                 935                 940                 


Ile Thr Ser Ala Glu Ser Glu Ser Ser Glu Glu Glu Glu Gly Glu Gln 
945                 950                 955                 960 


Gly Asp Pro Gln Asn Ala Thr Arg Gln Gln Gln Leu Glu Trp Asp Asp 
                965                 970                 975     


Ser Thr Leu Ser Tyr 
            980     


<210>  11
<211>  1842
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1842)

<400>  11
atg ggc gcc ctc agg ccc acg ctg ctg ccg cct tcg ctg ccg ctg ctg         48
Met Gly Ala Leu Arg Pro Thr Leu Leu Pro Pro Ser Leu Pro Leu Leu           
1               5                   10                  15                

ctg ctg cta atg cta gga atg gga tgc tgg gcc cgg gag gtg ctg gtc         96
Leu Leu Leu Met Leu Gly Met Gly Cys Trp Ala Arg Glu Val Leu Val           
            20                  25                  30                    

ccc gag ggg ccc ttg tac cgc gtg gct ggc aca gct gtc tcc atc tcc        144
Pro Glu Gly Pro Leu Tyr Arg Val Ala Gly Thr Ala Val Ser Ile Ser           
        35                  40                  45                        

tgc aat gtg acc ggc tat gag ggc cct gcc cag cag aac ttc gag tgg        192
Cys Asn Val Thr Gly Tyr Glu Gly Pro Ala Gln Gln Asn Phe Glu Trp           
    50                  55                  60                            

ttc ctg tat agg ccc gag gcc cca gat act gca ctg ggc att gtc agt        240
Phe Leu Tyr Arg Pro Glu Ala Pro Asp Thr Ala Leu Gly Ile Val Ser           
65                  70                  75                  80            

acc aag gat acc cag ttc tcc tat gct gtc ttc aag tcc cga gtg gtg        288
Thr Lys Asp Thr Gln Phe Ser Tyr Ala Val Phe Lys Ser Arg Val Val           
                85                  90                  95                

gcg ggt gag gtg cag gtg cag cgc cta caa ggt gat gcc gtg gtg ctc        336
Ala Gly Glu Val Gln Val Gln Arg Leu Gln Gly Asp Ala Val Val Leu           
            100                 105                 110                   

aag att gcc cgc ctg cag gcc cag gat gcc ggc att tat gag tgc cac        384
Lys Ile Ala Arg Leu Gln Ala Gln Asp Ala Gly Ile Tyr Glu Cys His           
        115                 120                 125                       

acc ccc tcc act gat acc cgc tac ctg ggc agc tac agc ggc aag gtg        432
Thr Pro Ser Thr Asp Thr Arg Tyr Leu Gly Ser Tyr Ser Gly Lys Val           
    130                 135                 140                           

gag ctg aga gtt ctt cca gat gtc ctc cag gtg tct gct gcc ccc cca        480
Glu Leu Arg Val Leu Pro Asp Val Leu Gln Val Ser Ala Ala Pro Pro           
145                 150                 155                 160           

ggg ccc cga ggc cgc cag gcc cca acc tca ccc cca cgc atg acg gtg        528
Gly Pro Arg Gly Arg Gln Ala Pro Thr Ser Pro Pro Arg Met Thr Val           
                165                 170                 175               

cat gag ggg cag gag ctg gca ctg ggc tgc ctg gcg agg aca agc aca        576
His Glu Gly Gln Glu Leu Ala Leu Gly Cys Leu Ala Arg Thr Ser Thr           
            180                 185                 190                   

cag aag cac aca cac ctg gca gtg tcc ttt ggg cga tct gtg ccc gag        624
Gln Lys His Thr His Leu Ala Val Ser Phe Gly Arg Ser Val Pro Glu           
        195                 200                 205                       

gca cca gtt ggg cgg tca act ctg cag gaa gtg gtg gga atc cgg tca        672
Ala Pro Val Gly Arg Ser Thr Leu Gln Glu Val Val Gly Ile Arg Ser           
    210                 215                 220                           

gac ttg gcc gtg gag gct gga gct ccc tat gct gag cga ttg gct gca        720
Asp Leu Ala Val Glu Ala Gly Ala Pro Tyr Ala Glu Arg Leu Ala Ala           
225                 230                 235                 240           

ggg gag ctt cgt ctg ggc aag gaa ggg acc gat cgg tac cgc atg gta        768
Gly Glu Leu Arg Leu Gly Lys Glu Gly Thr Asp Arg Tyr Arg Met Val           
                245                 250                 255               

gta ggg ggt gcc cag gca ggg gac gca ggc acc tac cac tgc act gcc        816
Val Gly Gly Ala Gln Ala Gly Asp Ala Gly Thr Tyr His Cys Thr Ala           
            260                 265                 270                   

gct gag tgg att cag gat cct gat ggc agc tgg gcc cag att gca gag        864
Ala Glu Trp Ile Gln Asp Pro Asp Gly Ser Trp Ala Gln Ile Ala Glu           
        275                 280                 285                       

aaa agg gcc gtc ctg gcc cac gtg gat gtg cag acg ctg tcc agc cag        912
Lys Arg Ala Val Leu Ala His Val Asp Val Gln Thr Leu Ser Ser Gln           
    290                 295                 300                           

ctg gca gtg aca gtg ggg cct ggt gaa cgt cgg atc ggc cca ggg gag        960
Leu Ala Val Thr Val Gly Pro Gly Glu Arg Arg Ile Gly Pro Gly Glu           
305                 310                 315                 320           

ccc ttg gaa ctg ctg tgc aat gtg tca ggg gca ctt ccc cca gca ggc       1008
Pro Leu Glu Leu Leu Cys Asn Val Ser Gly Ala Leu Pro Pro Ala Gly           
                325                 330                 335               

cgt cat gct gca tac tct gta ggt tgg gag atg gca cct gcg ggg gca       1056
Arg His Ala Ala Tyr Ser Val Gly Trp Glu Met Ala Pro Ala Gly Ala           
            340                 345                 350                   

cct ggg ccc ggc cgc ctg gta gcc cag ctg gac aca gag ggt gtg ggc       1104
Pro Gly Pro Gly Arg Leu Val Ala Gln Leu Asp Thr Glu Gly Val Gly           
        355                 360                 365                       

agc ctg ggc cct ggc tat gag ggc cga cac att gcc atg gag aag gtg       1152
Ser Leu Gly Pro Gly Tyr Glu Gly Arg His Ile Ala Met Glu Lys Val           
    370                 375                 380                           

gca tcc aga aca tac cgg cta cgg cta gag gct gcc agg cct ggt gat       1200
Ala Ser Arg Thr Tyr Arg Leu Arg Leu Glu Ala Ala Arg Pro Gly Asp           
385                 390                 395                 400           

gcg ggc acc tac cgc tgc ctc gcc aaa gcc tat gtt cga ggg tct ggg       1248
Ala Gly Thr Tyr Arg Cys Leu Ala Lys Ala Tyr Val Arg Gly Ser Gly           
                405                 410                 415               

acc cgg ctt cgt gaa gca gcc agt gcc cgt tcc cgg cct ctc cct gta       1296
Thr Arg Leu Arg Glu Ala Ala Ser Ala Arg Ser Arg Pro Leu Pro Val           
            420                 425                 430                   

cat gtg cgg gag gaa ggt gtg gtg ctg gag gct gtg gca tgg cta gca       1344
His Val Arg Glu Glu Gly Val Val Leu Glu Ala Val Ala Trp Leu Ala           
        435                 440                 445                       

gga ggc aca gtg tac cgc ggg gag act gcc tcc ctg ctg tgc aac atc       1392
Gly Gly Thr Val Tyr Arg Gly Glu Thr Ala Ser Leu Leu Cys Asn Ile           
    450                 455                 460                           

tct gtg cgg ggt ggc ccc cca gga ctg cgg ctg gcc gcc agc tgg tgg       1440
Ser Val Arg Gly Gly Pro Pro Gly Leu Arg Leu Ala Ala Ser Trp Trp           
465                 470                 475                 480           

gtg gag cga cca gag gac gga gag ctc agc tct gtc cct gcc cag ctg       1488
Val Glu Arg Pro Glu Asp Gly Glu Leu Ser Ser Val Pro Ala Gln Leu           
                485                 490                 495               

gtg ggt ggc gta ggc cag gat ggt gtg gca gag ctg gga gtc cgg cct       1536
Val Gly Gly Val Gly Gln Asp Gly Val Ala Glu Leu Gly Val Arg Pro           
            500                 505                 510                   

gga gga ggc cct gtc agc gta gag ctg gtg ggg ccc cga agc cat cgg       1584
Gly Gly Gly Pro Val Ser Val Glu Leu Val Gly Pro Arg Ser His Arg           
        515                 520                 525                       

ctg aga cta cac agc ttg ggg ccc gag gat gaa ggc gtg tac cac tgt       1632
Leu Arg Leu His Ser Leu Gly Pro Glu Asp Glu Gly Val Tyr His Cys           
    530                 535                 540                           

gcc ccc agc gcc tgg gtg cag cat gcc gac tac agc tgg tac cag gcg       1680
Ala Pro Ser Ala Trp Val Gln His Ala Asp Tyr Ser Trp Tyr Gln Ala           
545                 550                 555                 560           

ggc agt gcc cgc tca ggg cct gtt aca gtc tac ccc tac atg cat gcc       1728
Gly Ser Ala Arg Ser Gly Pro Val Thr Val Tyr Pro Tyr Met His Ala           
                565                 570                 575               

ctg gac acc cta ttt gtg cct ctg ctg gtg ggt aca ggg gtg gcc cta       1776
Leu Asp Thr Leu Phe Val Pro Leu Leu Val Gly Thr Gly Val Ala Leu           
            580                 585                 590                   

gtc act ggt gcc act gtc ctt ggt acc atc act tgc tgc ttc atg aag       1824
Val Thr Gly Ala Thr Val Leu Gly Thr Ile Thr Cys Cys Phe Met Lys           
        595                 600                 605                       

agg ctt cga aaa cgg tga                                               1842
Arg Leu Arg Lys Arg                                                       
    610                                                                   


<210>  12
<211>  613
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gly Ala Leu Arg Pro Thr Leu Leu Pro Pro Ser Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Met Leu Gly Met Gly Cys Trp Ala Arg Glu Val Leu Val 
            20                  25                  30          


Pro Glu Gly Pro Leu Tyr Arg Val Ala Gly Thr Ala Val Ser Ile Ser 
        35                  40                  45              


Cys Asn Val Thr Gly Tyr Glu Gly Pro Ala Gln Gln Asn Phe Glu Trp 
    50                  55                  60                  


Phe Leu Tyr Arg Pro Glu Ala Pro Asp Thr Ala Leu Gly Ile Val Ser 
65                  70                  75                  80  


Thr Lys Asp Thr Gln Phe Ser Tyr Ala Val Phe Lys Ser Arg Val Val 
                85                  90                  95      


Ala Gly Glu Val Gln Val Gln Arg Leu Gln Gly Asp Ala Val Val Leu 
            100                 105                 110         


Lys Ile Ala Arg Leu Gln Ala Gln Asp Ala Gly Ile Tyr Glu Cys His 
        115                 120                 125             


Thr Pro Ser Thr Asp Thr Arg Tyr Leu Gly Ser Tyr Ser Gly Lys Val 
    130                 135                 140                 


Glu Leu Arg Val Leu Pro Asp Val Leu Gln Val Ser Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Pro Arg Gly Arg Gln Ala Pro Thr Ser Pro Pro Arg Met Thr Val 
                165                 170                 175     


His Glu Gly Gln Glu Leu Ala Leu Gly Cys Leu Ala Arg Thr Ser Thr 
            180                 185                 190         


Gln Lys His Thr His Leu Ala Val Ser Phe Gly Arg Ser Val Pro Glu 
        195                 200                 205             


Ala Pro Val Gly Arg Ser Thr Leu Gln Glu Val Val Gly Ile Arg Ser 
    210                 215                 220                 


Asp Leu Ala Val Glu Ala Gly Ala Pro Tyr Ala Glu Arg Leu Ala Ala 
225                 230                 235                 240 


Gly Glu Leu Arg Leu Gly Lys Glu Gly Thr Asp Arg Tyr Arg Met Val 
                245                 250                 255     


Val Gly Gly Ala Gln Ala Gly Asp Ala Gly Thr Tyr His Cys Thr Ala 
            260                 265                 270         


Ala Glu Trp Ile Gln Asp Pro Asp Gly Ser Trp Ala Gln Ile Ala Glu 
        275                 280                 285             


Lys Arg Ala Val Leu Ala His Val Asp Val Gln Thr Leu Ser Ser Gln 
    290                 295                 300                 


Leu Ala Val Thr Val Gly Pro Gly Glu Arg Arg Ile Gly Pro Gly Glu 
305                 310                 315                 320 


Pro Leu Glu Leu Leu Cys Asn Val Ser Gly Ala Leu Pro Pro Ala Gly 
                325                 330                 335     


Arg His Ala Ala Tyr Ser Val Gly Trp Glu Met Ala Pro Ala Gly Ala 
            340                 345                 350         


Pro Gly Pro Gly Arg Leu Val Ala Gln Leu Asp Thr Glu Gly Val Gly 
        355                 360                 365             


Ser Leu Gly Pro Gly Tyr Glu Gly Arg His Ile Ala Met Glu Lys Val 
    370                 375                 380                 


Ala Ser Arg Thr Tyr Arg Leu Arg Leu Glu Ala Ala Arg Pro Gly Asp 
385                 390                 395                 400 


Ala Gly Thr Tyr Arg Cys Leu Ala Lys Ala Tyr Val Arg Gly Ser Gly 
                405                 410                 415     


Thr Arg Leu Arg Glu Ala Ala Ser Ala Arg Ser Arg Pro Leu Pro Val 
            420                 425                 430         


His Val Arg Glu Glu Gly Val Val Leu Glu Ala Val Ala Trp Leu Ala 
        435                 440                 445             


Gly Gly Thr Val Tyr Arg Gly Glu Thr Ala Ser Leu Leu Cys Asn Ile 
    450                 455                 460                 


Ser Val Arg Gly Gly Pro Pro Gly Leu Arg Leu Ala Ala Ser Trp Trp 
465                 470                 475                 480 


Val Glu Arg Pro Glu Asp Gly Glu Leu Ser Ser Val Pro Ala Gln Leu 
                485                 490                 495     


Val Gly Gly Val Gly Gln Asp Gly Val Ala Glu Leu Gly Val Arg Pro 
            500                 505                 510         


Gly Gly Gly Pro Val Ser Val Glu Leu Val Gly Pro Arg Ser His Arg 
        515                 520                 525             


Leu Arg Leu His Ser Leu Gly Pro Glu Asp Glu Gly Val Tyr His Cys 
    530                 535                 540                 


Ala Pro Ser Ala Trp Val Gln His Ala Asp Tyr Ser Trp Tyr Gln Ala 
545                 550                 555                 560 


Gly Ser Ala Arg Ser Gly Pro Val Thr Val Tyr Pro Tyr Met His Ala 
                565                 570                 575     


Leu Asp Thr Leu Phe Val Pro Leu Leu Val Gly Thr Gly Val Ala Leu 
            580                 585                 590         


Val Thr Gly Ala Thr Val Leu Gly Thr Ile Thr Cys Cys Phe Met Lys 
        595                 600                 605             


Arg Leu Arg Lys Arg 
    610             


<210>  13
<211>  1137
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1137)

<400>  13
atg gtc ctc ctt tgg ctc acg ctg ctc ctg atc gcc ctg ccc tgt ctc         48
Met Val Leu Leu Trp Leu Thr Leu Leu Leu Ile Ala Leu Pro Cys Leu           
1               5                   10                  15                

ctg caa acg aag gaa gat cca aac cca cca atc acg aac cta agg atg         96
Leu Gln Thr Lys Glu Asp Pro Asn Pro Pro Ile Thr Asn Leu Arg Met           
            20                  25                  30                    

aaa gca aag gct cag cag ttg acc tgg gac ctt aac aga aat gtg acc        144
Lys Ala Lys Ala Gln Gln Leu Thr Trp Asp Leu Asn Arg Asn Val Thr           
        35                  40                  45                        

gat atc gag tgt gtt aaa gac gcc gac tat tct atg ccg gca gtg aac        192
Asp Ile Glu Cys Val Lys Asp Ala Asp Tyr Ser Met Pro Ala Val Asn           
    50                  55                  60                            

aat agc tat tgc cag ttt gga gca att tcc tta tgt gaa gtg acc aac        240
Asn Ser Tyr Cys Gln Phe Gly Ala Ile Ser Leu Cys Glu Val Thr Asn           
65                  70                  75                  80            

tac acc gtc cga gtg gcc aac cca cca ttc tcc acg tgg atc ctc ttc        288
Tyr Thr Val Arg Val Ala Asn Pro Pro Phe Ser Thr Trp Ile Leu Phe           
                85                  90                  95                

cct gag aac agt ggg aag cct tgg gca ggt gcg gag aat ctg acc tgc        336
Pro Glu Asn Ser Gly Lys Pro Trp Ala Gly Ala Glu Asn Leu Thr Cys           
            100                 105                 110                   

tgg att cat gac gtg gat ttc ttg agc tgc agc tgg gcg gta ggc ccg        384
Trp Ile His Asp Val Asp Phe Leu Ser Cys Ser Trp Ala Val Gly Pro           
        115                 120                 125                       

ggg gcc ccc gcg gac gtc cag tac gac ctg tac ttg aac gtt gcc aac        432
Gly Ala Pro Ala Asp Val Gln Tyr Asp Leu Tyr Leu Asn Val Ala Asn           
    130                 135                 140                           

agg cgt caa cag tac gag tgt ctt cac tac aaa acg gat gct cag gga        480
Arg Arg Gln Gln Tyr Glu Cys Leu His Tyr Lys Thr Asp Ala Gln Gly           
145                 150                 155                 160           

aca cgt atc ggg tgt cgt ttc gat gac atc tct cga ctc tcc agc ggt        528
Thr Arg Ile Gly Cys Arg Phe Asp Asp Ile Ser Arg Leu Ser Ser Gly           
                165                 170                 175               

tct caa agt tcc cac atc ctg gtg cgg ggc agg agc gca gcc ttc ggt        576
Ser Gln Ser Ser His Ile Leu Val Arg Gly Arg Ser Ala Ala Phe Gly           
            180                 185                 190                   

atc ccc tgc aca gat aag ttt gtc gtc ttt tca cag att gag ata tta        624
Ile Pro Cys Thr Asp Lys Phe Val Val Phe Ser Gln Ile Glu Ile Leu           
        195                 200                 205                       

act cca ccc aac atg act gca aag tgt aat aag aca cat tcc ttt atg        672
Thr Pro Pro Asn Met Thr Ala Lys Cys Asn Lys Thr His Ser Phe Met           
    210                 215                 220                           

cac tgg aaa atg aga agt cat ttc aat cgc aaa ttt cgc tat gag ctt        720
His Trp Lys Met Arg Ser His Phe Asn Arg Lys Phe Arg Tyr Glu Leu           
225                 230                 235                 240           

cag ata caa aag aga atg cag cct gta atc aca gaa cag gtc aga gac        768
Gln Ile Gln Lys Arg Met Gln Pro Val Ile Thr Glu Gln Val Arg Asp           
                245                 250                 255               

aga acc tcc ttc cag cta ctc aat cct gga acg tac aca gta caa ata        816
Arg Thr Ser Phe Gln Leu Leu Asn Pro Gly Thr Tyr Thr Val Gln Ile           
            260                 265                 270                   

aga gcc cgg gaa aga gtg tat gaa ttc ttg agc gcc tgg agc acc ccc        864
Arg Ala Arg Glu Arg Val Tyr Glu Phe Leu Ser Ala Trp Ser Thr Pro           
        275                 280                 285                       

cag cgc ttc gag tgc gac cag gag gag ggc gca aac aca cgt gcc tgg        912
Gln Arg Phe Glu Cys Asp Gln Glu Glu Gly Ala Asn Thr Arg Ala Trp           
    290                 295                 300                           

cgg acg tcg ctg ctg atc gcg ctg ggg acg ctg ctg gcc ctg gtc tgt        960
Arg Thr Ser Leu Leu Ile Ala Leu Gly Thr Leu Leu Ala Leu Val Cys           
305                 310                 315                 320           

gtc ttc gtg atc tgc aga agg tat ctg gtg atg cag aga ctc ttt ccc       1008
Val Phe Val Ile Cys Arg Arg Tyr Leu Val Met Gln Arg Leu Phe Pro           
                325                 330                 335               

cgc atc cct cac atg aaa gac ccc atc ggt gac agc ttc caa aac gac       1056
Arg Ile Pro His Met Lys Asp Pro Ile Gly Asp Ser Phe Gln Asn Asp           
            340                 345                 350                   

aag ctg gtg gtc tgg gag gcg ggc aaa gcc ggc ctg gag gag tgt ctg       1104
Lys Leu Val Val Trp Glu Ala Gly Lys Ala Gly Leu Glu Glu Cys Leu           
        355                 360                 365                       

gtg act gaa gta cag gtc gtg cag aaa act tga                           1137
Val Thr Glu Val Gln Val Val Gln Lys Thr                                   
    370                 375                                               


<210>  14
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Val Leu Leu Trp Leu Thr Leu Leu Leu Ile Ala Leu Pro Cys Leu 
1               5                   10                  15      


Leu Gln Thr Lys Glu Asp Pro Asn Pro Pro Ile Thr Asn Leu Arg Met 
            20                  25                  30          


Lys Ala Lys Ala Gln Gln Leu Thr Trp Asp Leu Asn Arg Asn Val Thr 
        35                  40                  45              


Asp Ile Glu Cys Val Lys Asp Ala Asp Tyr Ser Met Pro Ala Val Asn 
    50                  55                  60                  


Asn Ser Tyr Cys Gln Phe Gly Ala Ile Ser Leu Cys Glu Val Thr Asn 
65                  70                  75                  80  


Tyr Thr Val Arg Val Ala Asn Pro Pro Phe Ser Thr Trp Ile Leu Phe 
                85                  90                  95      


Pro Glu Asn Ser Gly Lys Pro Trp Ala Gly Ala Glu Asn Leu Thr Cys 
            100                 105                 110         


Trp Ile His Asp Val Asp Phe Leu Ser Cys Ser Trp Ala Val Gly Pro 
        115                 120                 125             


Gly Ala Pro Ala Asp Val Gln Tyr Asp Leu Tyr Leu Asn Val Ala Asn 
    130                 135                 140                 


Arg Arg Gln Gln Tyr Glu Cys Leu His Tyr Lys Thr Asp Ala Gln Gly 
145                 150                 155                 160 


Thr Arg Ile Gly Cys Arg Phe Asp Asp Ile Ser Arg Leu Ser Ser Gly 
                165                 170                 175     


Ser Gln Ser Ser His Ile Leu Val Arg Gly Arg Ser Ala Ala Phe Gly 
            180                 185                 190         


Ile Pro Cys Thr Asp Lys Phe Val Val Phe Ser Gln Ile Glu Ile Leu 
        195                 200                 205             


Thr Pro Pro Asn Met Thr Ala Lys Cys Asn Lys Thr His Ser Phe Met 
    210                 215                 220                 


His Trp Lys Met Arg Ser His Phe Asn Arg Lys Phe Arg Tyr Glu Leu 
225                 230                 235                 240 


Gln Ile Gln Lys Arg Met Gln Pro Val Ile Thr Glu Gln Val Arg Asp 
                245                 250                 255     


Arg Thr Ser Phe Gln Leu Leu Asn Pro Gly Thr Tyr Thr Val Gln Ile 
            260                 265                 270         


Arg Ala Arg Glu Arg Val Tyr Glu Phe Leu Ser Ala Trp Ser Thr Pro 
        275                 280                 285             


Gln Arg Phe Glu Cys Asp Gln Glu Glu Gly Ala Asn Thr Arg Ala Trp 
    290                 295                 300                 


Arg Thr Ser Leu Leu Ile Ala Leu Gly Thr Leu Leu Ala Leu Val Cys 
305                 310                 315                 320 


Val Phe Val Ile Cys Arg Arg Tyr Leu Val Met Gln Arg Leu Phe Pro 
                325                 330                 335     


Arg Ile Pro His Met Lys Asp Pro Ile Gly Asp Ser Phe Gln Asn Asp 
            340                 345                 350         


Lys Leu Val Val Trp Glu Ala Gly Lys Ala Gly Leu Glu Glu Cys Leu 
        355                 360                 365             


Val Thr Glu Val Gln Val Val Gln Lys Thr 
    370                 375             


<210>  15
<211>  903
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(903)

<400>  15
atg gtc ctc ctt tgg ctc acg ctg ctc ctg atc gcc ctg ccc tgt ctc         48
Met Val Leu Leu Trp Leu Thr Leu Leu Leu Ile Ala Leu Pro Cys Leu           
1               5                   10                  15                

ctg caa acg aag gaa ggt ggg aag cct tgg gca ggt gcg gag aat ctg         96
Leu Gln Thr Lys Glu Gly Gly Lys Pro Trp Ala Gly Ala Glu Asn Leu           
            20                  25                  30                    

acc tgc tgg att cat gac gtg gat ttc ttg agc tgc agc tgg gcg gta        144
Thr Cys Trp Ile His Asp Val Asp Phe Leu Ser Cys Ser Trp Ala Val           
        35                  40                  45                        

ggc ccg ggg gcc ccc gcg gac gtc cag tac gac ctg tac ttg aac gtt        192
Gly Pro Gly Ala Pro Ala Asp Val Gln Tyr Asp Leu Tyr Leu Asn Val           
    50                  55                  60                            

gcc aac agg cgt caa cag tac gag tgt ctt cac tac aaa acg gat gct        240
Ala Asn Arg Arg Gln Gln Tyr Glu Cys Leu His Tyr Lys Thr Asp Ala           
65                  70                  75                  80            

cag gga aca cgt atc ggg tgt cgt ttc gat gac atc tct cga ctc tcc        288
Gln Gly Thr Arg Ile Gly Cys Arg Phe Asp Asp Ile Ser Arg Leu Ser           
                85                  90                  95                

agc ggt tct caa agt tcc cac atc ctg gtg cgg ggc agg agc gca gcc        336
Ser Gly Ser Gln Ser Ser His Ile Leu Val Arg Gly Arg Ser Ala Ala           
            100                 105                 110                   

ttc ggt atc ccc tgc aca gat aag ttt gtc gtc ttt tca cag att gag        384
Phe Gly Ile Pro Cys Thr Asp Lys Phe Val Val Phe Ser Gln Ile Glu           
        115                 120                 125                       

ata tta act cca ccc aac atg act gca aag tgt aat aag aca cat tcc        432
Ile Leu Thr Pro Pro Asn Met Thr Ala Lys Cys Asn Lys Thr His Ser           
    130                 135                 140                           

ttt atg cac tgg aaa atg aga agt cat ttc aat cgc aaa ttt cgc tat        480
Phe Met His Trp Lys Met Arg Ser His Phe Asn Arg Lys Phe Arg Tyr           
145                 150                 155                 160           

gag ctt cag ata caa aag aga atg cag cct gta atc aca gaa cag gtc        528
Glu Leu Gln Ile Gln Lys Arg Met Gln Pro Val Ile Thr Glu Gln Val           
                165                 170                 175               

aga gac aga acc tcc ttc cag cta ctc aat cct gga acg tac aca gta        576
Arg Asp Arg Thr Ser Phe Gln Leu Leu Asn Pro Gly Thr Tyr Thr Val           
            180                 185                 190                   

caa ata aga gcc cgg gaa aga gtg tat gaa ttc ttg agc gcc tgg agc        624
Gln Ile Arg Ala Arg Glu Arg Val Tyr Glu Phe Leu Ser Ala Trp Ser           
        195                 200                 205                       

acc ccc cag cgc ttc gag tgc gac cag gag gag ggc gca aac aca cgt        672
Thr Pro Gln Arg Phe Glu Cys Asp Gln Glu Glu Gly Ala Asn Thr Arg           
    210                 215                 220                           

gcc tgg cgg acg tcg ctg ctg atc gcg ctg ggg acg ctg ctg gcc ctg        720
Ala Trp Arg Thr Ser Leu Leu Ile Ala Leu Gly Thr Leu Leu Ala Leu           
225                 230                 235                 240           

gtc tgt gtc ttc gtg atc tgc aga agg tat ctg gtg atg cag aga ctc        768
Val Cys Val Phe Val Ile Cys Arg Arg Tyr Leu Val Met Gln Arg Leu           
                245                 250                 255               

ttt ccc cgc atc cct cac atg aaa gac ccc atc ggt gac agc ttc caa        816
Phe Pro Arg Ile Pro His Met Lys Asp Pro Ile Gly Asp Ser Phe Gln           
            260                 265                 270                   

aac gac aag ctg gtg gtc tgg gag gcg ggc aaa gcc ggc ctg gag gag        864
Asn Asp Lys Leu Val Val Trp Glu Ala Gly Lys Ala Gly Leu Glu Glu           
        275                 280                 285                       

tgt ctg gtg act gaa gta cag gtc gtg cag aaa act tga                    903
Cys Leu Val Thr Glu Val Gln Val Val Gln Lys Thr                           
    290                 295                 300                           


<210>  16
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Val Leu Leu Trp Leu Thr Leu Leu Leu Ile Ala Leu Pro Cys Leu 
1               5                   10                  15      


Leu Gln Thr Lys Glu Gly Gly Lys Pro Trp Ala Gly Ala Glu Asn Leu 
            20                  25                  30          


Thr Cys Trp Ile His Asp Val Asp Phe Leu Ser Cys Ser Trp Ala Val 
        35                  40                  45              


Gly Pro Gly Ala Pro Ala Asp Val Gln Tyr Asp Leu Tyr Leu Asn Val 
    50                  55                  60                  


Ala Asn Arg Arg Gln Gln Tyr Glu Cys Leu His Tyr Lys Thr Asp Ala 
65                  70                  75                  80  


Gln Gly Thr Arg Ile Gly Cys Arg Phe Asp Asp Ile Ser Arg Leu Ser 
                85                  90                  95      


Ser Gly Ser Gln Ser Ser His Ile Leu Val Arg Gly Arg Ser Ala Ala 
            100                 105                 110         


Phe Gly Ile Pro Cys Thr Asp Lys Phe Val Val Phe Ser Gln Ile Glu 
        115                 120                 125             


Ile Leu Thr Pro Pro Asn Met Thr Ala Lys Cys Asn Lys Thr His Ser 
    130                 135                 140                 


Phe Met His Trp Lys Met Arg Ser His Phe Asn Arg Lys Phe Arg Tyr 
145                 150                 155                 160 


Glu Leu Gln Ile Gln Lys Arg Met Gln Pro Val Ile Thr Glu Gln Val 
                165                 170                 175     


Arg Asp Arg Thr Ser Phe Gln Leu Leu Asn Pro Gly Thr Tyr Thr Val 
            180                 185                 190         


Gln Ile Arg Ala Arg Glu Arg Val Tyr Glu Phe Leu Ser Ala Trp Ser 
        195                 200                 205             


Thr Pro Gln Arg Phe Glu Cys Asp Gln Glu Glu Gly Ala Asn Thr Arg 
    210                 215                 220                 


Ala Trp Arg Thr Ser Leu Leu Ile Ala Leu Gly Thr Leu Leu Ala Leu 
225                 230                 235                 240 


Val Cys Val Phe Val Ile Cys Arg Arg Tyr Leu Val Met Gln Arg Leu 
                245                 250                 255     


Phe Pro Arg Ile Pro His Met Lys Asp Pro Ile Gly Asp Ser Phe Gln 
            260                 265                 270         


Asn Asp Lys Leu Val Val Trp Glu Ala Gly Lys Ala Gly Leu Glu Glu 
        275                 280                 285             


Cys Leu Val Thr Glu Val Gln Val Val Gln Lys Thr 
    290                 295                 300 


<210>  17
<211>  3201
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(3201)

<400>  17
atg ggc ccc ggc ccc agc cgc gcg ccc cgc gcc cca cgc ctg atg ctc         48
Met Gly Pro Gly Pro Ser Arg Ala Pro Arg Ala Pro Arg Leu Met Leu           
1               5                   10                  15                

tgt gcg ctc gcc ttg atg gtg gcg gcc ggc ggc tgc gtc gtc tcc gcc         96
Cys Ala Leu Ala Leu Met Val Ala Ala Gly Gly Cys Val Val Ser Ala           
            20                  25                  30                    

ttc aac ctg gat acc cga ttc ctg gta gtg aag gag gcc ggg aac ccg        144
Phe Asn Leu Asp Thr Arg Phe Leu Val Val Lys Glu Ala Gly Asn Pro           
        35                  40                  45                        

ggc agc ctc ttc ggc tac tcg gtc gcc ctc cat cgg cag aca gag cgg        192
Gly Ser Leu Phe Gly Tyr Ser Val Ala Leu His Arg Gln Thr Glu Arg           
    50                  55                  60                            

cag cag cgc tac ctg ctc ctg gct ggt gcc ccc cgg gag ctc gct gtg        240
Gln Gln Arg Tyr Leu Leu Leu Ala Gly Ala Pro Arg Glu Leu Ala Val           
65                  70                  75                  80            

ccc gat ggc tac acc aac cgg act ggt gct gtg tac ctg tgc cca ctc        288
Pro Asp Gly Tyr Thr Asn Arg Thr Gly Ala Val Tyr Leu Cys Pro Leu           
                85                  90                  95                

act gcc cac aag gat gac tgt gag cgg atg aac atc aca gtg aaa aat        336
Thr Ala His Lys Asp Asp Cys Glu Arg Met Asn Ile Thr Val Lys Asn           
            100                 105                 110                   

gac cct ggc cat cac att att gag gac atg tgg ctt gga gtg act gtg        384
Asp Pro Gly His His Ile Ile Glu Asp Met Trp Leu Gly Val Thr Val           
        115                 120                 125                       

gcc agc cag ggc cct gca ggc aga gtt ctg gtc tgt gcc cac cgc tac        432
Ala Ser Gln Gly Pro Ala Gly Arg Val Leu Val Cys Ala His Arg Tyr           
    130                 135                 140                           

acc cag gtg ctg tgg tca ggg tca gaa gac cag cgg cgc atg gtg ggc        480
Thr Gln Val Leu Trp Ser Gly Ser Glu Asp Gln Arg Arg Met Val Gly           
145                 150                 155                 160           

aag tgc tac gtg cga ggc aat gac cta gag ctg gac tcc agt gat gac        528
Lys Cys Tyr Val Arg Gly Asn Asp Leu Glu Leu Asp Ser Ser Asp Asp           
                165                 170                 175               

tgg cag acc tac cac aac gag atg tgc aat agc aac aca gac tac ctg        576
Trp Gln Thr Tyr His Asn Glu Met Cys Asn Ser Asn Thr Asp Tyr Leu           
            180                 185                 190                   

gag acg ggc atg tgc cag ctg ggc acc agc ggt ggc ttc acc cag aac        624
Glu Thr Gly Met Cys Gln Leu Gly Thr Ser Gly Gly Phe Thr Gln Asn           
        195                 200                 205                       

act gtg tac ttc ggc gcc ccc ggt gcc tac aac tgg aaa gga aac agc        672
Thr Val Tyr Phe Gly Ala Pro Gly Ala Tyr Asn Trp Lys Gly Asn Ser           
    210                 215                 220                           

tac atg att cag cgc aag gag tgg gac tta tct gag tat agt tac aag        720
Tyr Met Ile Gln Arg Lys Glu Trp Asp Leu Ser Glu Tyr Ser Tyr Lys           
225                 230                 235                 240           

gac cca gag gac caa gga aac ctc tat att ggg tac acg atg cag gta        768
Asp Pro Glu Asp Gln Gly Asn Leu Tyr Ile Gly Tyr Thr Met Gln Val           
                245                 250                 255               

ggc agc ttc atc ctg cac ccc aaa aac atc acc att gtg aca ggt gcc        816
Gly Ser Phe Ile Leu His Pro Lys Asn Ile Thr Ile Val Thr Gly Ala           
            260                 265                 270                   

cca cgg cac cga cat atg ggc gcg gtg ttc ttg ctg agc cag gag gca        864
Pro Arg His Arg His Met Gly Ala Val Phe Leu Leu Ser Gln Glu Ala           
        275                 280                 285                       

ggc gga gac ctg cgg agg agg cag gtg ctg gag ggc tcg cag gtg ggc        912
Gly Gly Asp Leu Arg Arg Arg Gln Val Leu Glu Gly Ser Gln Val Gly           
    290                 295                 300                           

gcc tat ttt ggc agc gcc att gcc ctg gca gac ctg aac aat gat ggg        960
Ala Tyr Phe Gly Ser Ala Ile Ala Leu Ala Asp Leu Asn Asn Asp Gly           
305                 310                 315                 320           

tgg cag gac ctc ctg gtg ggc gcc ccc tac tac ttc gag agg aaa gag       1008
Trp Gln Asp Leu Leu Val Gly Ala Pro Tyr Tyr Phe Glu Arg Lys Glu           
                325                 330                 335               

gaa gta ggg ggt gcc atc tat gtc ttc atg aac cag gcg gga acc tcc       1056
Glu Val Gly Gly Ala Ile Tyr Val Phe Met Asn Gln Ala Gly Thr Ser           
            340                 345                 350                   

ttc cct gct cac ccc tca ctc ctt ctt cat ggc ccc agt ggc tct gcc       1104
Phe Pro Ala His Pro Ser Leu Leu Leu His Gly Pro Ser Gly Ser Ala           
        355                 360                 365                       

ttt ggt tta tct gtg gcc agc att ggt gac atc aac cag gat gga ttt       1152
Phe Gly Leu Ser Val Ala Ser Ile Gly Asp Ile Asn Gln Asp Gly Phe           
    370                 375                 380                           

cag gat att gct gtg gga gct ccg ttt gaa ggc ttg ggc aaa gtg tac       1200
Gln Asp Ile Ala Val Gly Ala Pro Phe Glu Gly Leu Gly Lys Val Tyr           
385                 390                 395                 400           

atc tat cac agt agc tct aag ggg ctc ctt aga cag ccc cag cag gta       1248
Ile Tyr His Ser Ser Ser Lys Gly Leu Leu Arg Gln Pro Gln Gln Val           
                405                 410                 415               

atc cat gga gag aag ctg gga ctg cct ggg ttg gcc acc ttc ggc tat       1296
Ile His Gly Glu Lys Leu Gly Leu Pro Gly Leu Ala Thr Phe Gly Tyr           
            420                 425                 430                   

tcc ctc agt ggg cag atg gat gtg gat gag aac ttc tac cca gac ctt       1344
Ser Leu Ser Gly Gln Met Asp Val Asp Glu Asn Phe Tyr Pro Asp Leu           
        435                 440                 445                       

cta gtg gga agc ctg tca gac cac att gtg ctg ctg cgg gcc cgg ccc       1392
Leu Val Gly Ser Leu Ser Asp His Ile Val Leu Leu Arg Ala Arg Pro           
    450                 455                 460                           

gtc atc aac atc gtc cac aag acc ttg gtg ccc agg cca gct gtg ctg       1440
Val Ile Asn Ile Val His Lys Thr Leu Val Pro Arg Pro Ala Val Leu           
465                 470                 475                 480           

gac cct gca ctt tgc acg gcc acc tct tgt gtg caa gtg gag ctg tgc       1488
Asp Pro Ala Leu Cys Thr Ala Thr Ser Cys Val Gln Val Glu Leu Cys           
                485                 490                 495               

ttt gct tac aac cag agt gcc ggg aac ccc aac tac agg cga aac atc       1536
Phe Ala Tyr Asn Gln Ser Ala Gly Asn Pro Asn Tyr Arg Arg Asn Ile           
            500                 505                 510                   

acc ctg gcc tac act ctg gag gct gac agg gac cgc cgg ccg ccc cgg       1584
Thr Leu Ala Tyr Thr Leu Glu Ala Asp Arg Asp Arg Arg Pro Pro Arg           
        515                 520                 525                       

ctc cgc ttt gcc ggc agt gag tcc gct gtc ttc cac ggc ttc ttc tcc       1632
Leu Arg Phe Ala Gly Ser Glu Ser Ala Val Phe His Gly Phe Phe Ser           
    530                 535                 540                           

atg ccc gag atg cgc tgc cag aag ctg gag ctg ctc ctg atg gac aac       1680
Met Pro Glu Met Arg Cys Gln Lys Leu Glu Leu Leu Leu Met Asp Asn           
545                 550                 555                 560           

ctc cgt gac aaa ctc cgc ccc atc atc atc tcc atg aac tac tct tta       1728
Leu Arg Asp Lys Leu Arg Pro Ile Ile Ile Ser Met Asn Tyr Ser Leu           
                565                 570                 575               

cct ttg cgg atg ccc gat cgc ccc cgg ctg ggg ctg cgg tcc ctg gac       1776
Pro Leu Arg Met Pro Asp Arg Pro Arg Leu Gly Leu Arg Ser Leu Asp           
            580                 585                 590                   

gcc tac ccg atc ctc aac cag gca cag gct ctg gag aac cac act gag       1824
Ala Tyr Pro Ile Leu Asn Gln Ala Gln Ala Leu Glu Asn His Thr Glu           
        595                 600                 605                       

gtc cag ttc cag aag gag tgc ggg cct gac aac aag tgt gag agc aac       1872
Val Gln Phe Gln Lys Glu Cys Gly Pro Asp Asn Lys Cys Glu Ser Asn           
    610                 615                 620                           

ttg cag atg cgg gca gcc ttc gtg tca gag cag cag cag aag ctg agc       1920
Leu Gln Met Arg Ala Ala Phe Val Ser Glu Gln Gln Gln Lys Leu Ser           
625                 630                 635                 640           

agg ctc cag tac agc aga gac gtc cgg aaa ttg ctc ctg agc atc aac       1968
Arg Leu Gln Tyr Ser Arg Asp Val Arg Lys Leu Leu Leu Ser Ile Asn           
                645                 650                 655               

gtg acg aac acc cgg acc tcg gag cgc tcc ggg gag gac gcc cac gag       2016
Val Thr Asn Thr Arg Thr Ser Glu Arg Ser Gly Glu Asp Ala His Glu           
            660                 665                 670                   

gcg ctg ctc acc ctg gtg gtg cct ccc gcc ctg ctg ctg tcc tca gtg       2064
Ala Leu Leu Thr Leu Val Val Pro Pro Ala Leu Leu Leu Ser Ser Val           
        675                 680                 685                       

cgc ccc ccc ggg gcc tgc caa gct aat gag acc atc ttt tgc gag ctg       2112
Arg Pro Pro Gly Ala Cys Gln Ala Asn Glu Thr Ile Phe Cys Glu Leu           
    690                 695                 700                           

ggg aac ccc ttc aaa cgg aac cag agg atg gag ctg ctc atc gcc ttt       2160
Gly Asn Pro Phe Lys Arg Asn Gln Arg Met Glu Leu Leu Ile Ala Phe           
705                 710                 715                 720           

gag gtc atc ggg gtg acc ctg cac aca agg gac ctt cag gtg cag ctg       2208
Glu Val Ile Gly Val Thr Leu His Thr Arg Asp Leu Gln Val Gln Leu           
                725                 730                 735               

cag ctc tcc acg tcg agt cac cag gac aac ctg tgg ccc atg atc ctc       2256
Gln Leu Ser Thr Ser Ser His Gln Asp Asn Leu Trp Pro Met Ile Leu           
            740                 745                 750                   

act ctg ctg gtg gac tat aca ctc cag acc tcg ctt agc atg gta aat       2304
Thr Leu Leu Val Asp Tyr Thr Leu Gln Thr Ser Leu Ser Met Val Asn           
        755                 760                 765                       

cac cgg cta caa agc ttc ttt ggg ggg aca gtg atg ggt gag tct ggc       2352
His Arg Leu Gln Ser Phe Phe Gly Gly Thr Val Met Gly Glu Ser Gly           
    770                 775                 780                           

atg aaa act gtg gag gat gta gga agc ccc ctc aag tat gaa ttc cag       2400
Met Lys Thr Val Glu Asp Val Gly Ser Pro Leu Lys Tyr Glu Phe Gln           
785                 790                 795                 800           

gtg ggc cca atg ggg gag ggg ctg gtg ggc ctg ggg acc ctg gtc cta       2448
Val Gly Pro Met Gly Glu Gly Leu Val Gly Leu Gly Thr Leu Val Leu           
                805                 810                 815               

ggt ctg gag tgg ccc tac gaa gtc agc aat ggc aag tgg ctg ctg tat       2496
Gly Leu Glu Trp Pro Tyr Glu Val Ser Asn Gly Lys Trp Leu Leu Tyr           
            820                 825                 830                   

ccc acg gag atc acc gtc cat ggc aat ggg tcc tgg ccc tgc cga cca       2544
Pro Thr Glu Ile Thr Val His Gly Asn Gly Ser Trp Pro Cys Arg Pro           
        835                 840                 845                       

cct gga gac ctt atc aac cct ctc aac ctc act ctt tct gac cct ggg       2592
Pro Gly Asp Leu Ile Asn Pro Leu Asn Leu Thr Leu Ser Asp Pro Gly           
    850                 855                 860                           

gac agg cca tca tcc cca cag cgc agg cgg cga cag ctg gat cca ggg       2640
Asp Arg Pro Ser Ser Pro Gln Arg Arg Arg Arg Gln Leu Asp Pro Gly           
865                 870                 875                 880           

gga ggc cag ggc ccc cca cct gtc act ctg gct gct gcc aaa aaa gcc       2688
Gly Gly Gln Gly Pro Pro Pro Val Thr Leu Ala Ala Ala Lys Lys Ala           
                885                 890                 895               

aag tct gag act gtg ctg acc tgt gcc aca ggg cgt gcc cac tgt gtg       2736
Lys Ser Glu Thr Val Leu Thr Cys Ala Thr Gly Arg Ala His Cys Val           
            900                 905                 910                   

tgg cta gag tgc ccc atc cct gat gcc ccc gtt gtc acc aac gtg act       2784
Trp Leu Glu Cys Pro Ile Pro Asp Ala Pro Val Val Thr Asn Val Thr           
        915                 920                 925                       

gtg aag gca cga gtg tgg aac agc acc ttc atc gag gat tac aga gac       2832
Val Lys Ala Arg Val Trp Asn Ser Thr Phe Ile Glu Asp Tyr Arg Asp           
    930                 935                 940                           

ttt gac cga gtc cgg gta aat ggc tgg gct acc cta ttc ctc cga acc       2880
Phe Asp Arg Val Arg Val Asn Gly Trp Ala Thr Leu Phe Leu Arg Thr           
945                 950                 955                 960           

agc atc ccc acc atc aac atg gag aac aag acc acg tgg ttc tct gtg       2928
Ser Ile Pro Thr Ile Asn Met Glu Asn Lys Thr Thr Trp Phe Ser Val           
                965                 970                 975               

gac att gac tcg gag ctg gtg gag gag ctg ccg gcc gaa atc gag ctg       2976
Asp Ile Asp Ser Glu Leu Val Glu Glu Leu Pro Ala Glu Ile Glu Leu           
            980                 985                 990                   

tgg ctg gtg ctg gtg gcc gtg ggt  gca ggg ctg ctg ctg  ctg ggg ctg     3024
Trp Leu Val Leu Val Ala Val Gly  Ala Gly Leu Leu Leu  Leu Gly Leu         
        995                 1000                 1005                     

atc atc  ctc ctg ctg tgg aag  tgt gac ttc ttt aag  cgg acc cgc        3069
Ile Ile  Leu Leu Leu Trp Lys  Cys Asp Phe Phe Lys  Arg Thr Arg            
    1010                 1015                 1020                        

tat tat  cag atc atg ccc aag  tac cac gca gtg cgg  atc cgg gag        3114
Tyr Tyr  Gln Ile Met Pro Lys  Tyr His Ala Val Arg  Ile Arg Glu            
    1025                 1030                 1035                        

gag gag  cgc tac cca cct cca  ggg agc acc ctg ccc  acc aag aag        3159
Glu Glu  Arg Tyr Pro Pro Pro  Gly Ser Thr Leu Pro  Thr Lys Lys            
    1040                 1045                 1050                        

cac tgg  gtg acc agc tgg cag  act cgg gac caa tac  tac tga            3201
His Trp  Val Thr Ser Trp Gln  Thr Arg Asp Gln Tyr  Tyr                    
    1055                 1060                 1065                        


<210>  18
<211>  1066
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gly Pro Gly Pro Ser Arg Ala Pro Arg Ala Pro Arg Leu Met Leu 
1               5                   10                  15      


Cys Ala Leu Ala Leu Met Val Ala Ala Gly Gly Cys Val Val Ser Ala 
            20                  25                  30          


Phe Asn Leu Asp Thr Arg Phe Leu Val Val Lys Glu Ala Gly Asn Pro 
        35                  40                  45              


Gly Ser Leu Phe Gly Tyr Ser Val Ala Leu His Arg Gln Thr Glu Arg 
    50                  55                  60                  


Gln Gln Arg Tyr Leu Leu Leu Ala Gly Ala Pro Arg Glu Leu Ala Val 
65                  70                  75                  80  


Pro Asp Gly Tyr Thr Asn Arg Thr Gly Ala Val Tyr Leu Cys Pro Leu 
                85                  90                  95      


Thr Ala His Lys Asp Asp Cys Glu Arg Met Asn Ile Thr Val Lys Asn 
            100                 105                 110         


Asp Pro Gly His His Ile Ile Glu Asp Met Trp Leu Gly Val Thr Val 
        115                 120                 125             


Ala Ser Gln Gly Pro Ala Gly Arg Val Leu Val Cys Ala His Arg Tyr 
    130                 135                 140                 


Thr Gln Val Leu Trp Ser Gly Ser Glu Asp Gln Arg Arg Met Val Gly 
145                 150                 155                 160 


Lys Cys Tyr Val Arg Gly Asn Asp Leu Glu Leu Asp Ser Ser Asp Asp 
                165                 170                 175     


Trp Gln Thr Tyr His Asn Glu Met Cys Asn Ser Asn Thr Asp Tyr Leu 
            180                 185                 190         


Glu Thr Gly Met Cys Gln Leu Gly Thr Ser Gly Gly Phe Thr Gln Asn 
        195                 200                 205             


Thr Val Tyr Phe Gly Ala Pro Gly Ala Tyr Asn Trp Lys Gly Asn Ser 
    210                 215                 220                 


Tyr Met Ile Gln Arg Lys Glu Trp Asp Leu Ser Glu Tyr Ser Tyr Lys 
225                 230                 235                 240 


Asp Pro Glu Asp Gln Gly Asn Leu Tyr Ile Gly Tyr Thr Met Gln Val 
                245                 250                 255     


Gly Ser Phe Ile Leu His Pro Lys Asn Ile Thr Ile Val Thr Gly Ala 
            260                 265                 270         


Pro Arg His Arg His Met Gly Ala Val Phe Leu Leu Ser Gln Glu Ala 
        275                 280                 285             


Gly Gly Asp Leu Arg Arg Arg Gln Val Leu Glu Gly Ser Gln Val Gly 
    290                 295                 300                 


Ala Tyr Phe Gly Ser Ala Ile Ala Leu Ala Asp Leu Asn Asn Asp Gly 
305                 310                 315                 320 


Trp Gln Asp Leu Leu Val Gly Ala Pro Tyr Tyr Phe Glu Arg Lys Glu 
                325                 330                 335     


Glu Val Gly Gly Ala Ile Tyr Val Phe Met Asn Gln Ala Gly Thr Ser 
            340                 345                 350         


Phe Pro Ala His Pro Ser Leu Leu Leu His Gly Pro Ser Gly Ser Ala 
        355                 360                 365             


Phe Gly Leu Ser Val Ala Ser Ile Gly Asp Ile Asn Gln Asp Gly Phe 
    370                 375                 380                 


Gln Asp Ile Ala Val Gly Ala Pro Phe Glu Gly Leu Gly Lys Val Tyr 
385                 390                 395                 400 


Ile Tyr His Ser Ser Ser Lys Gly Leu Leu Arg Gln Pro Gln Gln Val 
                405                 410                 415     


Ile His Gly Glu Lys Leu Gly Leu Pro Gly Leu Ala Thr Phe Gly Tyr 
            420                 425                 430         


Ser Leu Ser Gly Gln Met Asp Val Asp Glu Asn Phe Tyr Pro Asp Leu 
        435                 440                 445             


Leu Val Gly Ser Leu Ser Asp His Ile Val Leu Leu Arg Ala Arg Pro 
    450                 455                 460                 


Val Ile Asn Ile Val His Lys Thr Leu Val Pro Arg Pro Ala Val Leu 
465                 470                 475                 480 


Asp Pro Ala Leu Cys Thr Ala Thr Ser Cys Val Gln Val Glu Leu Cys 
                485                 490                 495     


Phe Ala Tyr Asn Gln Ser Ala Gly Asn Pro Asn Tyr Arg Arg Asn Ile 
            500                 505                 510         


Thr Leu Ala Tyr Thr Leu Glu Ala Asp Arg Asp Arg Arg Pro Pro Arg 
        515                 520                 525             


Leu Arg Phe Ala Gly Ser Glu Ser Ala Val Phe His Gly Phe Phe Ser 
    530                 535                 540                 


Met Pro Glu Met Arg Cys Gln Lys Leu Glu Leu Leu Leu Met Asp Asn 
545                 550                 555                 560 


Leu Arg Asp Lys Leu Arg Pro Ile Ile Ile Ser Met Asn Tyr Ser Leu 
                565                 570                 575     


Pro Leu Arg Met Pro Asp Arg Pro Arg Leu Gly Leu Arg Ser Leu Asp 
            580                 585                 590         


Ala Tyr Pro Ile Leu Asn Gln Ala Gln Ala Leu Glu Asn His Thr Glu 
        595                 600                 605             


Val Gln Phe Gln Lys Glu Cys Gly Pro Asp Asn Lys Cys Glu Ser Asn 
    610                 615                 620                 


Leu Gln Met Arg Ala Ala Phe Val Ser Glu Gln Gln Gln Lys Leu Ser 
625                 630                 635                 640 


Arg Leu Gln Tyr Ser Arg Asp Val Arg Lys Leu Leu Leu Ser Ile Asn 
                645                 650                 655     


Val Thr Asn Thr Arg Thr Ser Glu Arg Ser Gly Glu Asp Ala His Glu 
            660                 665                 670         


Ala Leu Leu Thr Leu Val Val Pro Pro Ala Leu Leu Leu Ser Ser Val 
        675                 680                 685             


Arg Pro Pro Gly Ala Cys Gln Ala Asn Glu Thr Ile Phe Cys Glu Leu 
    690                 695                 700                 


Gly Asn Pro Phe Lys Arg Asn Gln Arg Met Glu Leu Leu Ile Ala Phe 
705                 710                 715                 720 


Glu Val Ile Gly Val Thr Leu His Thr Arg Asp Leu Gln Val Gln Leu 
                725                 730                 735     


Gln Leu Ser Thr Ser Ser His Gln Asp Asn Leu Trp Pro Met Ile Leu 
            740                 745                 750         


Thr Leu Leu Val Asp Tyr Thr Leu Gln Thr Ser Leu Ser Met Val Asn 
        755                 760                 765             


His Arg Leu Gln Ser Phe Phe Gly Gly Thr Val Met Gly Glu Ser Gly 
    770                 775                 780                 


Met Lys Thr Val Glu Asp Val Gly Ser Pro Leu Lys Tyr Glu Phe Gln 
785                 790                 795                 800 


Val Gly Pro Met Gly Glu Gly Leu Val Gly Leu Gly Thr Leu Val Leu 
                805                 810                 815     


Gly Leu Glu Trp Pro Tyr Glu Val Ser Asn Gly Lys Trp Leu Leu Tyr 
            820                 825                 830         


Pro Thr Glu Ile Thr Val His Gly Asn Gly Ser Trp Pro Cys Arg Pro 
        835                 840                 845             


Pro Gly Asp Leu Ile Asn Pro Leu Asn Leu Thr Leu Ser Asp Pro Gly 
    850                 855                 860                 


Asp Arg Pro Ser Ser Pro Gln Arg Arg Arg Arg Gln Leu Asp Pro Gly 
865                 870                 875                 880 


Gly Gly Gln Gly Pro Pro Pro Val Thr Leu Ala Ala Ala Lys Lys Ala 
                885                 890                 895     


Lys Ser Glu Thr Val Leu Thr Cys Ala Thr Gly Arg Ala His Cys Val 
            900                 905                 910         


Trp Leu Glu Cys Pro Ile Pro Asp Ala Pro Val Val Thr Asn Val Thr 
        915                 920                 925             


Val Lys Ala Arg Val Trp Asn Ser Thr Phe Ile Glu Asp Tyr Arg Asp 
    930                 935                 940                 


Phe Asp Arg Val Arg Val Asn Gly Trp Ala Thr Leu Phe Leu Arg Thr 
945                 950                 955                 960 


Ser Ile Pro Thr Ile Asn Met Glu Asn Lys Thr Thr Trp Phe Ser Val 
                965                 970                 975     


Asp Ile Asp Ser Glu Leu Val Glu Glu Leu Pro Ala Glu Ile Glu Leu 
            980                 985                 990         


Trp Leu Val Leu Val Ala Val Gly  Ala Gly Leu Leu Leu  Leu Gly Leu 
        995                 1000                 1005             


Ile Ile  Leu Leu Leu Trp Lys  Cys Asp Phe Phe Lys  Arg Thr Arg 
    1010                 1015                 1020             


Tyr Tyr  Gln Ile Met Pro Lys  Tyr His Ala Val Arg  Ile Arg Glu 
    1025                 1030                 1035             


Glu Glu  Arg Tyr Pro Pro Pro  Gly Ser Thr Leu Pro  Thr Lys Lys 
    1040                 1045                 1050             


His Trp  Val Thr Ser Trp Gln  Thr Arg Asp Gln Tyr  Tyr 
    1055                 1060                 1065     


<210>  19
<211>  3156
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(3156)

<400>  19
atg ggc ccc ggc ccc agc cgc gcg ccc cgc gcc cca cgc ctg atg ctc         48
Met Gly Pro Gly Pro Ser Arg Ala Pro Arg Ala Pro Arg Leu Met Leu           
1               5                   10                  15                

tgt gcg ctc gcc ttg atg gtg gcg gcc ggc ggc tgc gtc gtc tcc gcc         96
Cys Ala Leu Ala Leu Met Val Ala Ala Gly Gly Cys Val Val Ser Ala           
            20                  25                  30                    

ttc aac ctg gat acc cga ttc ctg gta gtg aag gag gcc ggg aac ccg        144
Phe Asn Leu Asp Thr Arg Phe Leu Val Val Lys Glu Ala Gly Asn Pro           
        35                  40                  45                        

ggc agc ctc ttc ggc tac tcg gtc gcc ctc cat cgg cag aca gag cgg        192
Gly Ser Leu Phe Gly Tyr Ser Val Ala Leu His Arg Gln Thr Glu Arg           
    50                  55                  60                            

cag cag cgc tac ctg ctc ctg gct ggt gcc ccc cgg gag ctc gct gtg        240
Gln Gln Arg Tyr Leu Leu Leu Ala Gly Ala Pro Arg Glu Leu Ala Val           
65                  70                  75                  80            

ccc gat ggc tac acc aac cgg act ggt gct gtg tac ctg tgc cca ctc        288
Pro Asp Gly Tyr Thr Asn Arg Thr Gly Ala Val Tyr Leu Cys Pro Leu           
                85                  90                  95                

act gcc cac aag gat gac tgt gag cgg atg aac atc aca gtg aaa aat        336
Thr Ala His Lys Asp Asp Cys Glu Arg Met Asn Ile Thr Val Lys Asn           
            100                 105                 110                   

gac cct ggc cat cac att att gag gac atg tgg ctt gga gtg act gtg        384
Asp Pro Gly His His Ile Ile Glu Asp Met Trp Leu Gly Val Thr Val           
        115                 120                 125                       

gcc agc cag ggc cct gca ggc aga gtt ctg gtc tgt gcc cac cgc tac        432
Ala Ser Gln Gly Pro Ala Gly Arg Val Leu Val Cys Ala His Arg Tyr           
    130                 135                 140                           

acc cag gtg ctg tgg tca ggg tca gaa gac cag cgg cgc atg gtg ggc        480
Thr Gln Val Leu Trp Ser Gly Ser Glu Asp Gln Arg Arg Met Val Gly           
145                 150                 155                 160           

aag tgc tac gtg cga ggc aat gac cta gag ctg gac tcc agt gat gac        528
Lys Cys Tyr Val Arg Gly Asn Asp Leu Glu Leu Asp Ser Ser Asp Asp           
                165                 170                 175               

tgg cag acc tac cac aac gag atg tgc aat agc aac aca gac tac ctg        576
Trp Gln Thr Tyr His Asn Glu Met Cys Asn Ser Asn Thr Asp Tyr Leu           
            180                 185                 190                   

gag acg ggc atg tgc cag ctg ggc acc agc ggt ggc ttc acc cag aac        624
Glu Thr Gly Met Cys Gln Leu Gly Thr Ser Gly Gly Phe Thr Gln Asn           
        195                 200                 205                       

act gtg tac ttc ggc gcc ccc ggt gcc tac aac tgg aaa gga aac agc        672
Thr Val Tyr Phe Gly Ala Pro Gly Ala Tyr Asn Trp Lys Gly Asn Ser           
    210                 215                 220                           

tac atg att cag cgc aag gag tgg gac tta tct gag tat agt tac aag        720
Tyr Met Ile Gln Arg Lys Glu Trp Asp Leu Ser Glu Tyr Ser Tyr Lys           
225                 230                 235                 240           

gac cca gag gac caa gga aac ctc tat att ggg tac acg atg cag gta        768
Asp Pro Glu Asp Gln Gly Asn Leu Tyr Ile Gly Tyr Thr Met Gln Val           
                245                 250                 255               

ggc agc ttc atc ctg cac ccc aaa aac atc acc att gtg aca ggt gcc        816
Gly Ser Phe Ile Leu His Pro Lys Asn Ile Thr Ile Val Thr Gly Ala           
            260                 265                 270                   

cca cgg cac cga cat atg ggc gcg gtg ttc ttg ctg agc cag gag gca        864
Pro Arg His Arg His Met Gly Ala Val Phe Leu Leu Ser Gln Glu Ala           
        275                 280                 285                       

ggc gga gac ctg cgg agg agg cag gtg ctg gag ggc tcg cag gtg ggc        912
Gly Gly Asp Leu Arg Arg Arg Gln Val Leu Glu Gly Ser Gln Val Gly           
    290                 295                 300                           

gcc tat ttt ggc agc gcc att gcc ctg gca gac ctg aac aat gat ggg        960
Ala Tyr Phe Gly Ser Ala Ile Ala Leu Ala Asp Leu Asn Asn Asp Gly           
305                 310                 315                 320           

tgg cag gac ctc ctg gtg ggc gcc ccc tac tac ttc gag agg aaa gag       1008
Trp Gln Asp Leu Leu Val Gly Ala Pro Tyr Tyr Phe Glu Arg Lys Glu           
                325                 330                 335               

gaa gta ggg ggt gcc atc tat gtc ttc atg aac cag gcg gga acc tcc       1056
Glu Val Gly Gly Ala Ile Tyr Val Phe Met Asn Gln Ala Gly Thr Ser           
            340                 345                 350                   

ttc cct gct cac ccc tca ctc ctt ctt cat ggc ccc agt ggc tct gcc       1104
Phe Pro Ala His Pro Ser Leu Leu Leu His Gly Pro Ser Gly Ser Ala           
        355                 360                 365                       

ttt ggt tta tct gtg gcc agc att ggt gac atc aac cag gat gga ttt       1152
Phe Gly Leu Ser Val Ala Ser Ile Gly Asp Ile Asn Gln Asp Gly Phe           
    370                 375                 380                           

cag gat att gct gtg gga gct ccg ttt gaa ggc ttg ggc aaa gtg tac       1200
Gln Asp Ile Ala Val Gly Ala Pro Phe Glu Gly Leu Gly Lys Val Tyr           
385                 390                 395                 400           

atc tat cac agt agc tct aag ggg ctc ctt aga cag ccc cag cag gta       1248
Ile Tyr His Ser Ser Ser Lys Gly Leu Leu Arg Gln Pro Gln Gln Val           
                405                 410                 415               

atc cat gga gag aag ctg gga ctg cct ggg ttg gcc acc ttc ggc tat       1296
Ile His Gly Glu Lys Leu Gly Leu Pro Gly Leu Ala Thr Phe Gly Tyr           
            420                 425                 430                   

tcc ctc agt ggg cag atg gat gtg gat gag aac ttc tac cca gac ctt       1344
Ser Leu Ser Gly Gln Met Asp Val Asp Glu Asn Phe Tyr Pro Asp Leu           
        435                 440                 445                       

cta gtg gga agc ctg tca gac cac att gtg ctg ctg cgg gcc cgg ccc       1392
Leu Val Gly Ser Leu Ser Asp His Ile Val Leu Leu Arg Ala Arg Pro           
    450                 455                 460                           

gtc atc aac atc gtc cac aag acc ttg gtg ccc agg cca gct gtg ctg       1440
Val Ile Asn Ile Val His Lys Thr Leu Val Pro Arg Pro Ala Val Leu           
465                 470                 475                 480           

gac cct gca ctt tgc acg gcc acc tct tgt gtg caa gtg gag ctg tgc       1488
Asp Pro Ala Leu Cys Thr Ala Thr Ser Cys Val Gln Val Glu Leu Cys           
                485                 490                 495               

ttt gct tac aac cag agt gcc ggg aac ccc aac tac agg cga aac atc       1536
Phe Ala Tyr Asn Gln Ser Ala Gly Asn Pro Asn Tyr Arg Arg Asn Ile           
            500                 505                 510                   

acc ctg gcc tac act ctg gag gct gac agg gac cgc cgg ccg ccc cgg       1584
Thr Leu Ala Tyr Thr Leu Glu Ala Asp Arg Asp Arg Arg Pro Pro Arg           
        515                 520                 525                       

ctc cgc ttt gcc ggc agt gag tcc gct gtc ttc cac ggc ttc ttc tcc       1632
Leu Arg Phe Ala Gly Ser Glu Ser Ala Val Phe His Gly Phe Phe Ser           
    530                 535                 540                           

atg ccc gag atg cgc tgc cag aag ctg gag ctg ctc ctg atg gac aac       1680
Met Pro Glu Met Arg Cys Gln Lys Leu Glu Leu Leu Leu Met Asp Asn           
545                 550                 555                 560           

ctc cgt gac aaa ctc cgc ccc atc atc atc tcc atg aac tac tct tta       1728
Leu Arg Asp Lys Leu Arg Pro Ile Ile Ile Ser Met Asn Tyr Ser Leu           
                565                 570                 575               

cct ttg cgg atg ccc gat cgc ccc cgg ctg ggg ctg cgg tcc ctg gac       1776
Pro Leu Arg Met Pro Asp Arg Pro Arg Leu Gly Leu Arg Ser Leu Asp           
            580                 585                 590                   

gcc tac ccg atc ctc aac cag gca cag gct ctg gag aac cac act gag       1824
Ala Tyr Pro Ile Leu Asn Gln Ala Gln Ala Leu Glu Asn His Thr Glu           
        595                 600                 605                       

gtc cag ttc cag aag gag tgc ggg cct gac aac aag tgt gag agc aac       1872
Val Gln Phe Gln Lys Glu Cys Gly Pro Asp Asn Lys Cys Glu Ser Asn           
    610                 615                 620                           

ttg cag atg cgg gca gcc ttc gtg tca gag cag cag cag aag ctg agc       1920
Leu Gln Met Arg Ala Ala Phe Val Ser Glu Gln Gln Gln Lys Leu Ser           
625                 630                 635                 640           

agg ctc cag tac agc aga gac gtc cgg aaa ttg ctc ctg agc atc aac       1968
Arg Leu Gln Tyr Ser Arg Asp Val Arg Lys Leu Leu Leu Ser Ile Asn           
                645                 650                 655               

gtg acg aac acc cgg acc tcg gag cgc tcc ggg gag gac gcc cac gag       2016
Val Thr Asn Thr Arg Thr Ser Glu Arg Ser Gly Glu Asp Ala His Glu           
            660                 665                 670                   

gcg ctg ctc acc ctg gtg gtg cct ccc gcc ctg ctg ctg tcc tca gtg       2064
Ala Leu Leu Thr Leu Val Val Pro Pro Ala Leu Leu Leu Ser Ser Val           
        675                 680                 685                       

cgc ccc ccc ggg gcc tgc caa gct aat gag acc atc ttt tgc gag ctg       2112
Arg Pro Pro Gly Ala Cys Gln Ala Asn Glu Thr Ile Phe Cys Glu Leu           
    690                 695                 700                           

ggg aac ccc ttc aaa cgg aac cag agg atg gag ctg ctc atc gcc ttt       2160
Gly Asn Pro Phe Lys Arg Asn Gln Arg Met Glu Leu Leu Ile Ala Phe           
705                 710                 715                 720           

gag gtc atc ggg gtg acc ctg cac aca agg gac ctt cag gtg cag ctg       2208
Glu Val Ile Gly Val Thr Leu His Thr Arg Asp Leu Gln Val Gln Leu           
                725                 730                 735               

cag ctc tcc acg tcg agt cac cag gac aac ctg tgg ccc atg atc ctc       2256
Gln Leu Ser Thr Ser Ser His Gln Asp Asn Leu Trp Pro Met Ile Leu           
            740                 745                 750                   

act ctg ctg gtg gac tat aca ctc cag acc tcg ctt agc atg gta aat       2304
Thr Leu Leu Val Asp Tyr Thr Leu Gln Thr Ser Leu Ser Met Val Asn           
        755                 760                 765                       

cac cgg cta caa agc ttc ttt ggg ggg aca gtg atg ggt gag tct ggc       2352
His Arg Leu Gln Ser Phe Phe Gly Gly Thr Val Met Gly Glu Ser Gly           
    770                 775                 780                           

atg aaa act gtg gag gat gta gga agc ccc ctc aag tat gaa ttc cag       2400
Met Lys Thr Val Glu Asp Val Gly Ser Pro Leu Lys Tyr Glu Phe Gln           
785                 790                 795                 800           

gtg ggc cca atg ggg gag ggg ctg gtg ggc ctg ggg acc ctg gtc cta       2448
Val Gly Pro Met Gly Glu Gly Leu Val Gly Leu Gly Thr Leu Val Leu           
                805                 810                 815               

ggt ctg gag tgg ccc tac gaa gtc agc aat ggc aag tgg ctg ctg tat       2496
Gly Leu Glu Trp Pro Tyr Glu Val Ser Asn Gly Lys Trp Leu Leu Tyr           
            820                 825                 830                   

ccc acg gag atc acc gtc cat ggc aat ggg tcc tgg ccc tgc cga cca       2544
Pro Thr Glu Ile Thr Val His Gly Asn Gly Ser Trp Pro Cys Arg Pro           
        835                 840                 845                       

cct gga gac ctt atc aac cct ctc aac ctc act ctt tct gac cct ggg       2592
Pro Gly Asp Leu Ile Asn Pro Leu Asn Leu Thr Leu Ser Asp Pro Gly           
    850                 855                 860                           

gac agg cca tca tcc cca cag cgc agg cgg cga cag ctg gat cca ggg       2640
Asp Arg Pro Ser Ser Pro Gln Arg Arg Arg Arg Gln Leu Asp Pro Gly           
865                 870                 875                 880           

gga ggc cag ggc ccc cca cct gtc act ctg gct gct gcc aaa aaa gcc       2688
Gly Gly Gln Gly Pro Pro Pro Val Thr Leu Ala Ala Ala Lys Lys Ala           
                885                 890                 895               

aag tct gag act gtg ctg acc tgt gcc aca ggg cgt gcc cac tgt gtg       2736
Lys Ser Glu Thr Val Leu Thr Cys Ala Thr Gly Arg Ala His Cys Val           
            900                 905                 910                   

tgg cta gag tgc ccc atc cct gat gcc ccc gtt gtc acc aac gtg act       2784
Trp Leu Glu Cys Pro Ile Pro Asp Ala Pro Val Val Thr Asn Val Thr           
        915                 920                 925                       

gtg aag gca cga gtg tgg aac agc acc ttc atc gag gat tac aga gac       2832
Val Lys Ala Arg Val Trp Asn Ser Thr Phe Ile Glu Asp Tyr Arg Asp           
    930                 935                 940                           

ttt gac cga gtc cgg gta aat ggc tgg gct acc cta ttc ctc cga acc       2880
Phe Asp Arg Val Arg Val Asn Gly Trp Ala Thr Leu Phe Leu Arg Thr           
945                 950                 955                 960           

agc atc ccc acc atc aac atg gag aac aag acc acg tgg ttc tct gtg       2928
Ser Ile Pro Thr Ile Asn Met Glu Asn Lys Thr Thr Trp Phe Ser Val           
                965                 970                 975               

gac att gac tcg gag ctg gtg gag gag ctg ccg gcc gaa atc gag ctg       2976
Asp Ile Asp Ser Glu Leu Val Glu Glu Leu Pro Ala Glu Ile Glu Leu           
            980                 985                 990                   

tgg ctg gtg ctg gtg gcc gtg ggt  gca ggg ctg ctg ctg  ctg ggg ctg     3024
Trp Leu Val Leu Val Ala Val Gly  Ala Gly Leu Leu Leu  Leu Gly Leu         
        995                 1000                 1005                     

atc atc  ctc ctg ctg tgg aag  tgc ggc ttc ttc aag  cga gcc cgc        3069
Ile Ile  Leu Leu Leu Trp Lys  Cys Gly Phe Phe Lys  Arg Ala Arg            
    1010                 1015                 1020                        

act cgc  gcc ctg tat gaa gct  aag agg cag aag gcg  gag atg aag        3114
Thr Arg  Ala Leu Tyr Glu Ala  Lys Arg Gln Lys Ala  Glu Met Lys            
    1025                 1030                 1035                        

agc cag  ccg tca gag aca gag  agg ctg acc gac gac  tac tga            3156
Ser Gln  Pro Ser Glu Thr Glu  Arg Leu Thr Asp Asp  Tyr                    
    1040                 1045                 1050                        


<210>  20
<211>  1051
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Gly Pro Gly Pro Ser Arg Ala Pro Arg Ala Pro Arg Leu Met Leu 
1               5                   10                  15      


Cys Ala Leu Ala Leu Met Val Ala Ala Gly Gly Cys Val Val Ser Ala 
            20                  25                  30          


Phe Asn Leu Asp Thr Arg Phe Leu Val Val Lys Glu Ala Gly Asn Pro 
        35                  40                  45              


Gly Ser Leu Phe Gly Tyr Ser Val Ala Leu His Arg Gln Thr Glu Arg 
    50                  55                  60                  


Gln Gln Arg Tyr Leu Leu Leu Ala Gly Ala Pro Arg Glu Leu Ala Val 
65                  70                  75                  80  


Pro Asp Gly Tyr Thr Asn Arg Thr Gly Ala Val Tyr Leu Cys Pro Leu 
                85                  90                  95      


Thr Ala His Lys Asp Asp Cys Glu Arg Met Asn Ile Thr Val Lys Asn 
            100                 105                 110         


Asp Pro Gly His His Ile Ile Glu Asp Met Trp Leu Gly Val Thr Val 
        115                 120                 125             


Ala Ser Gln Gly Pro Ala Gly Arg Val Leu Val Cys Ala His Arg Tyr 
    130                 135                 140                 


Thr Gln Val Leu Trp Ser Gly Ser Glu Asp Gln Arg Arg Met Val Gly 
145                 150                 155                 160 


Lys Cys Tyr Val Arg Gly Asn Asp Leu Glu Leu Asp Ser Ser Asp Asp 
                165                 170                 175     


Trp Gln Thr Tyr His Asn Glu Met Cys Asn Ser Asn Thr Asp Tyr Leu 
            180                 185                 190         


Glu Thr Gly Met Cys Gln Leu Gly Thr Ser Gly Gly Phe Thr Gln Asn 
        195                 200                 205             


Thr Val Tyr Phe Gly Ala Pro Gly Ala Tyr Asn Trp Lys Gly Asn Ser 
    210                 215                 220                 


Tyr Met Ile Gln Arg Lys Glu Trp Asp Leu Ser Glu Tyr Ser Tyr Lys 
225                 230                 235                 240 


Asp Pro Glu Asp Gln Gly Asn Leu Tyr Ile Gly Tyr Thr Met Gln Val 
                245                 250                 255     


Gly Ser Phe Ile Leu His Pro Lys Asn Ile Thr Ile Val Thr Gly Ala 
            260                 265                 270         


Pro Arg His Arg His Met Gly Ala Val Phe Leu Leu Ser Gln Glu Ala 
        275                 280                 285             


Gly Gly Asp Leu Arg Arg Arg Gln Val Leu Glu Gly Ser Gln Val Gly 
    290                 295                 300                 


Ala Tyr Phe Gly Ser Ala Ile Ala Leu Ala Asp Leu Asn Asn Asp Gly 
305                 310                 315                 320 


Trp Gln Asp Leu Leu Val Gly Ala Pro Tyr Tyr Phe Glu Arg Lys Glu 
                325                 330                 335     


Glu Val Gly Gly Ala Ile Tyr Val Phe Met Asn Gln Ala Gly Thr Ser 
            340                 345                 350         


Phe Pro Ala His Pro Ser Leu Leu Leu His Gly Pro Ser Gly Ser Ala 
        355                 360                 365             


Phe Gly Leu Ser Val Ala Ser Ile Gly Asp Ile Asn Gln Asp Gly Phe 
    370                 375                 380                 


Gln Asp Ile Ala Val Gly Ala Pro Phe Glu Gly Leu Gly Lys Val Tyr 
385                 390                 395                 400 


Ile Tyr His Ser Ser Ser Lys Gly Leu Leu Arg Gln Pro Gln Gln Val 
                405                 410                 415     


Ile His Gly Glu Lys Leu Gly Leu Pro Gly Leu Ala Thr Phe Gly Tyr 
            420                 425                 430         


Ser Leu Ser Gly Gln Met Asp Val Asp Glu Asn Phe Tyr Pro Asp Leu 
        435                 440                 445             


Leu Val Gly Ser Leu Ser Asp His Ile Val Leu Leu Arg Ala Arg Pro 
    450                 455                 460                 


Val Ile Asn Ile Val His Lys Thr Leu Val Pro Arg Pro Ala Val Leu 
465                 470                 475                 480 


Asp Pro Ala Leu Cys Thr Ala Thr Ser Cys Val Gln Val Glu Leu Cys 
                485                 490                 495     


Phe Ala Tyr Asn Gln Ser Ala Gly Asn Pro Asn Tyr Arg Arg Asn Ile 
            500                 505                 510         


Thr Leu Ala Tyr Thr Leu Glu Ala Asp Arg Asp Arg Arg Pro Pro Arg 
        515                 520                 525             


Leu Arg Phe Ala Gly Ser Glu Ser Ala Val Phe His Gly Phe Phe Ser 
    530                 535                 540                 


Met Pro Glu Met Arg Cys Gln Lys Leu Glu Leu Leu Leu Met Asp Asn 
545                 550                 555                 560 


Leu Arg Asp Lys Leu Arg Pro Ile Ile Ile Ser Met Asn Tyr Ser Leu 
                565                 570                 575     


Pro Leu Arg Met Pro Asp Arg Pro Arg Leu Gly Leu Arg Ser Leu Asp 
            580                 585                 590         


Ala Tyr Pro Ile Leu Asn Gln Ala Gln Ala Leu Glu Asn His Thr Glu 
        595                 600                 605             


Val Gln Phe Gln Lys Glu Cys Gly Pro Asp Asn Lys Cys Glu Ser Asn 
    610                 615                 620                 


Leu Gln Met Arg Ala Ala Phe Val Ser Glu Gln Gln Gln Lys Leu Ser 
625                 630                 635                 640 


Arg Leu Gln Tyr Ser Arg Asp Val Arg Lys Leu Leu Leu Ser Ile Asn 
                645                 650                 655     


Val Thr Asn Thr Arg Thr Ser Glu Arg Ser Gly Glu Asp Ala His Glu 
            660                 665                 670         


Ala Leu Leu Thr Leu Val Val Pro Pro Ala Leu Leu Leu Ser Ser Val 
        675                 680                 685             


Arg Pro Pro Gly Ala Cys Gln Ala Asn Glu Thr Ile Phe Cys Glu Leu 
    690                 695                 700                 


Gly Asn Pro Phe Lys Arg Asn Gln Arg Met Glu Leu Leu Ile Ala Phe 
705                 710                 715                 720 


Glu Val Ile Gly Val Thr Leu His Thr Arg Asp Leu Gln Val Gln Leu 
                725                 730                 735     


Gln Leu Ser Thr Ser Ser His Gln Asp Asn Leu Trp Pro Met Ile Leu 
            740                 745                 750         


Thr Leu Leu Val Asp Tyr Thr Leu Gln Thr Ser Leu Ser Met Val Asn 
        755                 760                 765             


His Arg Leu Gln Ser Phe Phe Gly Gly Thr Val Met Gly Glu Ser Gly 
    770                 775                 780                 


Met Lys Thr Val Glu Asp Val Gly Ser Pro Leu Lys Tyr Glu Phe Gln 
785                 790                 795                 800 


Val Gly Pro Met Gly Glu Gly Leu Val Gly Leu Gly Thr Leu Val Leu 
                805                 810                 815     


Gly Leu Glu Trp Pro Tyr Glu Val Ser Asn Gly Lys Trp Leu Leu Tyr 
            820                 825                 830         


Pro Thr Glu Ile Thr Val His Gly Asn Gly Ser Trp Pro Cys Arg Pro 
        835                 840                 845             


Pro Gly Asp Leu Ile Asn Pro Leu Asn Leu Thr Leu Ser Asp Pro Gly 
    850                 855                 860                 


Asp Arg Pro Ser Ser Pro Gln Arg Arg Arg Arg Gln Leu Asp Pro Gly 
865                 870                 875                 880 


Gly Gly Gln Gly Pro Pro Pro Val Thr Leu Ala Ala Ala Lys Lys Ala 
                885                 890                 895     


Lys Ser Glu Thr Val Leu Thr Cys Ala Thr Gly Arg Ala His Cys Val 
            900                 905                 910         


Trp Leu Glu Cys Pro Ile Pro Asp Ala Pro Val Val Thr Asn Val Thr 
        915                 920                 925             


Val Lys Ala Arg Val Trp Asn Ser Thr Phe Ile Glu Asp Tyr Arg Asp 
    930                 935                 940                 


Phe Asp Arg Val Arg Val Asn Gly Trp Ala Thr Leu Phe Leu Arg Thr 
945                 950                 955                 960 


Ser Ile Pro Thr Ile Asn Met Glu Asn Lys Thr Thr Trp Phe Ser Val 
                965                 970                 975     


Asp Ile Asp Ser Glu Leu Val Glu Glu Leu Pro Ala Glu Ile Glu Leu 
            980                 985                 990         


Trp Leu Val Leu Val Ala Val Gly  Ala Gly Leu Leu Leu  Leu Gly Leu 
        995                 1000                 1005             


Ile Ile  Leu Leu Leu Trp Lys  Cys Gly Phe Phe Lys  Arg Ala Arg 
    1010                 1015                 1020             


Thr Arg  Ala Leu Tyr Glu Ala  Lys Arg Gln Lys Ala  Glu Met Lys 
    1025                 1030                 1035             


Ser Gln  Pro Ser Glu Thr Glu  Arg Leu Thr Asp Asp  Tyr 
    1040                 1045                 1050     


<210>  21
<211>  2397
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(2397)

<400>  21
atg aat tta caa cca att ttc tgg att gga ctg atc agt tca gtt tgc         48
Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys           
1               5                   10                  15                

tgt gtg ttt gct caa aca gat gaa aat aga tgt tta aaa gca aat gcc         96
Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala           
            20                  25                  30                    

aaa tca tgt gga gaa tgt ata caa gca ggg cca aat tgt ggg tgg tgc        144
Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys           
        35                  40                  45                        

aca aat tca aca ttt tta cag gaa gga atg cct act tct gca cga tgt        192
Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys           
    50                  55                  60                            

gat gat tta gaa gcc tta aaa aag aag ggt tgc cct cca gat gac ata        240
Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile           
65                  70                  75                  80            

gaa aat ccc aga ggc tcc aaa gat ata aag aaa aat aaa aat gta acc        288
Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr           
                85                  90                  95                

aac cgt agc aaa gga aca gca gag aag ctc aag cca gag gat att act        336
Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr           
            100                 105                 110                   

cag atc caa cca cag cag ttg gtt ttg cga tta aga tca ggg gag cca        384
Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro           
        115                 120                 125                       

cag aca ttt aca tta aaa ttc aag aga gct gaa gac tat ccc att gac        432
Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp           
    130                 135                 140                           

ctc tac tac ctt atg gac ctg tct tac tca atg aaa gac gat ttg gag        480
Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu           
145                 150                 155                 160           

aat gta aaa agt ctt gga aca gat ctg atg aat gaa atg agg agg att        528
Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile           
                165                 170                 175               

act tcg gac ttc aga att gga ttt ggc tca ttt gtg gaa aag act gtg        576
Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val           
            180                 185                 190                   

atg cct tac att agc aca aca cca gct aag ctc agg aac cct tgc aca        624
Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr           
        195                 200                 205                       

agt gaa cag aac tgc acc agc cca ttt agc tac aaa aat gtg ctc agt        672
Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser           
    210                 215                 220                           

ctt act aat aaa gga gaa gta ttt aat gaa ctt gtt gga aaa cag cgc        720
Leu Thr Asn Lys Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg           
225                 230                 235                 240           

ata tct gga aat ttg gat tct cca gaa ggt ggt ttc gat gcc atc atg        768
Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met           
                245                 250                 255               

caa gtt gca gtt tgt gga tca ctg att ggc tgg agg aat gtt aca cgg        816
Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg           
            260                 265                 270                   

ctg ctg gtg ttt tcc aca gat gcc ggg ttt cac ttt gct gga gat ggg        864
Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly           
        275                 280                 285                       

aaa ctt ggt ggc att gtt tta cca aat gat gga caa tgt cac ctg gaa        912
Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu           
    290                 295                 300                           

aat aat atg tac aca atg agc cat tat tat gat tat cct tct att gct        960
Asn Asn Met Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala           
305                 310                 315                 320           

cac ctt gtc cag aaa ctg agt gaa aat aat att cag aca att ttt gca       1008
His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala           
                325                 330                 335               

gtt act gaa gaa ttt cag cct gtt tac aag gag ctg aaa aac ttg atc       1056
Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile           
            340                 345                 350                   

cct aag tca gca gta gga aca tta tct gca aat tct agc aat gta att       1104
Pro Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile           
        355                 360                 365                       

cag ttg atc att gat gca tac aat tcc ctt tcc tca gaa gtc att ttg       1152
Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu           
    370                 375                 380                           

gaa aac ggc aaa ttg tca gaa ggc gta aca ata agt tac aaa tct tac       1200
Glu Asn Gly Lys Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr           
385                 390                 395                 400           

tgc aag aac ggg gtg aat gga aca ggg gaa aat gga aga aaa tgt tcc       1248
Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser           
                405                 410                 415               

aat att tcc att gga gat gag gtt caa ttt gaa att agc ata act tca       1296
Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser           
            420                 425                 430                   

aat aag tgt cca aaa aag gat tct gac agc ttt aaa att agg cct ctg       1344
Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu           
        435                 440                 445                       

ggc ttt acg gag gaa gta gag gtt att ctt cag tac atc tgt gaa tgt       1392
Gly Phe Thr Glu Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys           
    450                 455                 460                           

gaa tgc caa agc gaa ggc atc cct gaa agt ccc aag tgt cat gaa gga       1440
Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly           
465                 470                 475                 480           

aat ggg aca ttt gag tgt ggc gcg tgc agg tgc aat gaa ggg cgt gtt       1488
Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val           
                485                 490                 495               

ggt aga cat tgt gaa tgc agc aca gat gaa gtt aac agt gaa gac atg       1536
Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met           
            500                 505                 510                   

gat gct tac tgc agg aaa gaa aac agt tca gaa atc tgc agt aac aat       1584
Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn           
        515                 520                 525                       

gga gag tgc gtc tgc gga cag tgt gtt tgt agg aag agg gat aat aca       1632
Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr           
    530                 535                 540                           

aat gaa att tat tct ggc aaa ttc tgc gag tgt gat aat ttc aac tgt       1680
Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys           
545                 550                 555                 560           

gat aga tcc aat ggc tta att tgt gga gga aat ggt gtt tgc aag tgt       1728
Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys           
                565                 570                 575               

cgt gtg tgt gag tgc aac ccc aac tac act ggc agt gca tgt gac tgt       1776
Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys           
            580                 585                 590                   

tct ttg gat act agt act tgt gaa gcc agc aac gga cag atc tgc aat       1824
Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn           
        595                 600                 605                       

ggc cgg ggc atc tgc gag tgt ggt gtc tgt aag tgt aca gat ccg aag       1872
Gly Arg Gly Ile Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys           
    610                 615                 620                           

ttt caa ggg caa acg tgt gag atg tgt cag acc tgc ctt ggt gtc tgt       1920
Phe Gln Gly Gln Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys           
625                 630                 635                 640           

gct gag cat aaa gaa tgt gtt cag tgc aga gcc ttc aat aaa gga gaa       1968
Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu           
                645                 650                 655               

aag aaa gac aca tgc aca cag gaa tgt tcc tat ttt aac att acc aag       2016
Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys           
            660                 665                 670                   

gta gaa agt cgg gac aaa tta ccc cag ccg gtc caa cct gat cct gtg       2064
Val Glu Ser Arg Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val           
        675                 680                 685                       

tcc cat tgt aag gag aag gat gtt gac gac tgt tgg ttc tat ttt acg       2112
Ser His Cys Lys Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr           
    690                 695                 700                           

tat tca gtg aat ggg aac aac gag gtc atg gtt cat gtt gtg gag aat       2160
Tyr Ser Val Asn Gly Asn Asn Glu Val Met Val His Val Val Glu Asn           
705                 710                 715                 720           

cca gag tgt ccc act ggt cca gac atc att cca att gta gct ggt gtg       2208
Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val           
                725                 730                 735               

gtt gct gga att gtt ctt att ggc ctt gca tta ctg ctg ata tgg aag       2256
Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys           
            740                 745                 750                   

ctt tta atg ata att cat gac aga agg gag ttt gct aaa ttt gaa aag       2304
Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys           
        755                 760                 765                       

gag aaa atg aat gcc aaa tgg gac acg ggt gaa aat cct att tat aag       2352
Glu Lys Met Asn Ala Lys Trp Asp Thr Gly Glu Asn Pro Ile Tyr Lys           
    770                 775                 780                           

agt gcc gta aca act gtg gtc aat ccg aag tat gag gga aaa tga           2397
Ser Ala Val Thr Thr Val Val Asn Pro Lys Tyr Glu Gly Lys                   
785                 790                 795                               


<210>  22
<211>  798
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp 
    130                 135                 140                 


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu 
145                 150                 155                 160 


Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile 
                165                 170                 175     


Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val 
            180                 185                 190         


Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr 
        195                 200                 205             


Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser 
    210                 215                 220                 


Leu Thr Asn Lys Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg 
225                 230                 235                 240 


Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met 
                245                 250                 255     


Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg 
            260                 265                 270         


Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly 
        275                 280                 285             


Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu 
    290                 295                 300                 


Asn Asn Met Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala 
305                 310                 315                 320 


His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala 
                325                 330                 335     


Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile 
            340                 345                 350         


Pro Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile 
        355                 360                 365             


Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu 
    370                 375                 380                 


Glu Asn Gly Lys Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr 
385                 390                 395                 400 


Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser 
                405                 410                 415     


Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser 
            420                 425                 430         


Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu 
        435                 440                 445             


Gly Phe Thr Glu Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys 
    450                 455                 460                 


Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly 
465                 470                 475                 480 


Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val 
                485                 490                 495     


Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met 
            500                 505                 510         


Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn 
        515                 520                 525             


Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr 
    530                 535                 540                 


Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys 
545                 550                 555                 560 


Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys 
                565                 570                 575     


Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys 
            580                 585                 590         


Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn 
        595                 600                 605             


Gly Arg Gly Ile Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys 
    610                 615                 620                 


Phe Gln Gly Gln Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys 
625                 630                 635                 640 


Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu 
                645                 650                 655     


Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys 
            660                 665                 670         


Val Glu Ser Arg Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val 
        675                 680                 685             


Ser His Cys Lys Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr 
    690                 695                 700                 


Tyr Ser Val Asn Gly Asn Asn Glu Val Met Val His Val Val Glu Asn 
705                 710                 715                 720 


Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val 
                725                 730                 735     


Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys 
            740                 745                 750         


Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys 
        755                 760                 765             


Glu Lys Met Asn Ala Lys Trp Asp Thr Gly Glu Asn Pro Ile Tyr Lys 
    770                 775                 780                 


Ser Ala Val Thr Thr Val Val Asn Pro Lys Tyr Glu Gly Lys 
785                 790                 795             


<210>  23
<211>  2406
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(2406)

<400>  23
atg aat tta caa cca att ttc tgg att gga ctg atc agt tca gtt tgc         48
Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys           
1               5                   10                  15                

tgt gtg ttt gct caa aca gat gaa aat aga tgt tta aaa gca aat gcc         96
Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala           
            20                  25                  30                    

aaa tca tgt gga gaa tgt ata caa gca ggg cca aat tgt ggg tgg tgc        144
Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys           
        35                  40                  45                        

aca aat tca aca ttt tta cag gaa gga atg cct act tct gca cga tgt        192
Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys           
    50                  55                  60                            

gat gat tta gaa gcc tta aaa aag aag ggt tgc cct cca gat gac ata        240
Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile           
65                  70                  75                  80            

gaa aat ccc aga ggc tcc aaa gat ata aag aaa aat aaa aat gta acc        288
Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr           
                85                  90                  95                

aac cgt agc aaa gga aca gca gag aag ctc aag cca gag gat att act        336
Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr           
            100                 105                 110                   

cag atc caa cca cag cag ttg gtt ttg cga tta aga tca ggg gag cca        384
Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro           
        115                 120                 125                       

cag aca ttt aca tta aaa ttc aag aga gct gaa gac tat ccc att gac        432
Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp           
    130                 135                 140                           

ctc tac tac ctt atg gac ctg tct tac tca atg aaa gac gat ttg gag        480
Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu           
145                 150                 155                 160           

aat gta aaa agt ctt gga aca gat ctg atg aat gaa atg agg agg att        528
Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile           
                165                 170                 175               

act tcg gac ttc aga att gga ttt ggc tca ttt gtg gaa aag act gtg        576
Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val           
            180                 185                 190                   

atg cct tac att agc aca aca cca gct aag ctc agg aac cct tgc aca        624
Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr           
        195                 200                 205                       

agt gaa cag aac tgc acc agc cca ttt agc tac aaa aat gtg ctc agt        672
Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser           
    210                 215                 220                           

ctt act aat aaa gga gaa gta ttt aat gaa ctt gtt gga aaa cag cgc        720
Leu Thr Asn Lys Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg           
225                 230                 235                 240           

ata tct gga aat ttg gat tct cca gaa ggt ggt ttc gat gcc atc atg        768
Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met           
                245                 250                 255               

caa gtt gca gtt tgt gga tca ctg att ggc tgg agg aat gtt aca cgg        816
Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg           
            260                 265                 270                   

ctg ctg gtg ttt tcc aca gat gcc ggg ttt cac ttt gct gga gat ggg        864
Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly           
        275                 280                 285                       

aaa ctt ggt ggc att gtt tta cca aat gat gga caa tgt cac ctg gaa        912
Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu           
    290                 295                 300                           

aat aat atg tac aca atg agc cat tat tat gat tat cct tct att gct        960
Asn Asn Met Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala           
305                 310                 315                 320           

cac ctt gtc cag aaa ctg agt gaa aat aat att cag aca att ttt gca       1008
His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala           
                325                 330                 335               

gtt act gaa gaa ttt cag cct gtt tac aag gag ctg aaa aac ttg atc       1056
Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile           
            340                 345                 350                   

cct aag tca gca gta gga aca tta tct gca aat tct agc aat gta att       1104
Pro Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile           
        355                 360                 365                       

cag ttg atc att gat gca tac aat tcc ctt tcc tca gaa gtc att ttg       1152
Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu           
    370                 375                 380                           

gaa aac ggc aaa ttg tca gaa ggc gta aca ata agt tac aaa tct tac       1200
Glu Asn Gly Lys Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr           
385                 390                 395                 400           

tgc aag aac ggg gtg aat gga aca ggg gaa aat gga aga aaa tgt tcc       1248
Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser           
                405                 410                 415               

aat att tcc att gga gat gag gtt caa ttt gaa att agc ata act tca       1296
Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser           
            420                 425                 430                   

aat aag tgt cca aaa aag gat tct gac agc ttt aaa att agg cct ctg       1344
Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu           
        435                 440                 445                       

ggc ttt acg gag gaa gta gag gtt att ctt cag tac atc tgt gaa tgt       1392
Gly Phe Thr Glu Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys           
    450                 455                 460                           

gaa tgc caa agc gaa ggc atc cct gaa agt ccc aag tgt cat gaa gga       1440
Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly           
465                 470                 475                 480           

aat ggg aca ttt gag tgt ggc gcg tgc agg tgc aat gaa ggg cgt gtt       1488
Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val           
                485                 490                 495               

ggt aga cat tgt gaa tgc agc aca gat gaa gtt aac agt gaa gac atg       1536
Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met           
            500                 505                 510                   

gat gct tac tgc agg aaa gaa aac agt tca gaa atc tgc agt aac aat       1584
Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn           
        515                 520                 525                       

gga gag tgc gtc tgc gga cag tgt gtt tgt agg aag agg gat aat aca       1632
Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr           
    530                 535                 540                           

aat gaa att tat tct ggc aaa ttc tgc gag tgt gat aat ttc aac tgt       1680
Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys           
545                 550                 555                 560           

gat aga tcc aat ggc tta att tgt gga gga aat ggt gtt tgc aag tgt       1728
Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys           
                565                 570                 575               

cgt gtg tgt gag tgc aac ccc aac tac act ggc agt gca tgt gac tgt       1776
Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys           
            580                 585                 590                   

tct ttg gat act agt act tgt gaa gcc agc aac gga cag atc tgc aat       1824
Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn           
        595                 600                 605                       

ggc cgg ggc atc tgc gag tgt ggt gtc tgt aag tgt aca gat ccg aag       1872
Gly Arg Gly Ile Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys           
    610                 615                 620                           

ttt caa ggg caa acg tgt gag atg tgt cag acc tgc ctt ggt gtc tgt       1920
Phe Gln Gly Gln Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys           
625                 630                 635                 640           

gct gag cat aaa gaa tgt gtt cag tgc aga gcc ttc aat aaa gga gaa       1968
Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu           
                645                 650                 655               

aag aaa gac aca tgc aca cag gaa tgt tcc tat ttt aac att acc aag       2016
Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys           
            660                 665                 670                   

gta gaa agt cgg gac aaa tta ccc cag ccg gtc caa cct gat cct gtg       2064
Val Glu Ser Arg Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val           
        675                 680                 685                       

tcc cat tgt aag gag aag gat gtt gac gac tgt tgg ttc tat ttt acg       2112
Ser His Cys Lys Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr           
    690                 695                 700                           

tat tca gtg aat ggg aac aac gag gtc atg gtt cat gtt gtg gag aat       2160
Tyr Ser Val Asn Gly Asn Asn Glu Val Met Val His Val Val Glu Asn           
705                 710                 715                 720           

cca gag tgt ccc act ggt cca gac atc att cca att gta gct ggt gtg       2208
Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val           
                725                 730                 735               

gtt gct gga att gtt ctt att ggc ctt gca tta ctg ctg ata tgg aag       2256
Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys           
            740                 745                 750                   

ctt tta atg ata att cat gac aga agg gag ttt gct aaa ttt gaa aag       2304
Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys           
        755                 760                 765                       

gag aaa atg aat gcc aaa tgg gac acg caa gaa aat ccg att tac aag       2352
Glu Lys Met Asn Ala Lys Trp Asp Thr Gln Glu Asn Pro Ile Tyr Lys           
    770                 775                 780                           

agt cct att aat aat ttc aag aat cca aac tac gga cgt aaa gct ggt       2400
Ser Pro Ile Asn Asn Phe Lys Asn Pro Asn Tyr Gly Arg Lys Ala Gly           
785                 790                 795                 800           

ctc taa                                                               2406
Leu                                                                       
                                                                          


<210>  24
<211>  801
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp 
    130                 135                 140                 


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu 
145                 150                 155                 160 


Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile 
                165                 170                 175     


Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val 
            180                 185                 190         


Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr 
        195                 200                 205             


Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser 
    210                 215                 220                 


Leu Thr Asn Lys Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg 
225                 230                 235                 240 


Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met 
                245                 250                 255     


Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg 
            260                 265                 270         


Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly 
        275                 280                 285             


Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu 
    290                 295                 300                 


Asn Asn Met Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala 
305                 310                 315                 320 


His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala 
                325                 330                 335     


Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile 
            340                 345                 350         


Pro Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile 
        355                 360                 365             


Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu 
    370                 375                 380                 


Glu Asn Gly Lys Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr 
385                 390                 395                 400 


Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser 
                405                 410                 415     


Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser 
            420                 425                 430         


Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu 
        435                 440                 445             


Gly Phe Thr Glu Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys 
    450                 455                 460                 


Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly 
465                 470                 475                 480 


Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val 
                485                 490                 495     


Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met 
            500                 505                 510         


Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn 
        515                 520                 525             


Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr 
    530                 535                 540                 


Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys 
545                 550                 555                 560 


Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys 
                565                 570                 575     


Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys 
            580                 585                 590         


Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn 
        595                 600                 605             


Gly Arg Gly Ile Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys 
    610                 615                 620                 


Phe Gln Gly Gln Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys 
625                 630                 635                 640 


Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu 
                645                 650                 655     


Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys 
            660                 665                 670         


Val Glu Ser Arg Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val 
        675                 680                 685             


Ser His Cys Lys Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr 
    690                 695                 700                 


Tyr Ser Val Asn Gly Asn Asn Glu Val Met Val His Val Val Glu Asn 
705                 710                 715                 720 


Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val 
                725                 730                 735     


Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys 
            740                 745                 750         


Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys 
        755                 760                 765             


Glu Lys Met Asn Ala Lys Trp Asp Thr Gln Glu Asn Pro Ile Tyr Lys 
    770                 775                 780                 


Ser Pro Ile Asn Asn Phe Lys Asn Pro Asn Tyr Gly Arg Lys Ala Gly 
785                 790                 795                 800 


Leu 
    


<210>  25
<211>  1233
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1233)

<400>  25
atg gtg tgc ttc cgc ctc ttc ccg gtt ccg ggc tca ggg ctc gtt ctg         48
Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu           
1               5                   10                  15                

gtc tgc cta gtc ctg gga gct gtg cgg tct tat gca ttg gaa ctt aat         96
Val Cys Leu Val Leu Gly Ala Val Arg Ser Tyr Ala Leu Glu Leu Asn           
            20                  25                  30                    

ttg aca gat tca gaa aat gcc act tgc ctt tat gca aaa tgg cag atg        144
Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met           
        35                  40                  45                        

aat ttc aca gta cgc tat gaa act aca aat aaa act tat aaa act gta        192
Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr Val           
    50                  55                  60                            

acc att tca gac cat ggc act gtg aca tat aat gga agc att tgt ggg        240
Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys Gly           
65                  70                  75                  80            

gat gat cag aat ggt ccc aaa ata gca gtg cag ttc gga cct ggc ttt        288
Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly Phe           
                85                  90                  95                

tcc tgg att gcg aat ttt acc aag gca gca tct act tat tca att gac        336
Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile Asp           
            100                 105                 110                   

agc gtc tca ttt tcc tac aac act ggt gat aac aca aca ttt cct gat        384
Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp           
        115                 120                 125                       

gct gaa gat aaa gga att ctt act gtt gat gaa ctt ttg gcc atc aga        432
Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile Arg           
    130                 135                 140                           

att cca ttg aat gac ctt ttt aga tgc aat agt tta tca act ttg gaa        480
Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu           
145                 150                 155                 160           

aag aat gat gtt gtc caa cac tac tgg gat gtt ctt gta caa gct ttt        528
Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala Phe           
                165                 170                 175               

gtc caa aat ggc aca gtg agc aca aat gag ttc ctg tgt gat aaa gac        576
Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys Asp           
            180                 185                 190                   

aaa act tca aca gtg gca ccc acc ata cac acc act gtg cca tct cct        624
Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser Pro           
        195                 200                 205                       

act aca aca cct act cca aag gaa aaa cca gaa gct gga acc tat tca        672
Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr Ser           
    210                 215                 220                           

gtt aat aat ggc aat gat act tgt ctg ctg gct acc atg ggg ctg cag        720
Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu Gln           
225                 230                 235                 240           

ctg aac atc act cag gat aag gtt gct tca gtt att aac atc aac ccc        768
Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn Pro           
                245                 250                 255               

aat aca act cac tcc aca ggc agc tgc cgt tct cac act gct cta ctt        816
Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu Leu           
            260                 265                 270                   

aga ctc aat agc agc acc att aag tat cta gac ttt gtc ttt gct gtg        864
Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala Val           
        275                 280                 285                       

aaa aat gaa aac cga ttt tat ctg aag gaa gtg aac atc agc atg tat        912
Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met Tyr           
    290                 295                 300                           

ttg gtt aat ggc tcc gtt ttc agc att gca aat aac aat ctc agc tac        960
Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser Tyr           
305                 310                 315                 320           

tgg gat gcc ccc ctg gga agt tct tat atg tgc aac aaa gag cag act       1008
Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr           
                325                 330                 335               

gtt tca gtg tct gga gca ttt cag ata aat acc ttt gat cta agg gtt       1056
Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg Val           
            340                 345                 350                   

cag cct ttc aat gtg aca caa gga aag tat tct aca gct caa gac tgc       1104
Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Asp Cys           
        355                 360                 365                       

agt gca gat gac gac aac ttc ctt gtg ccc ata gcg gtg gga gct gcc       1152
Ser Ala Asp Asp Asp Asn Phe Leu Val Pro Ile Ala Val Gly Ala Ala           
    370                 375                 380                           

ttg gca gga gta ctt att cta gtg ttg ctg gct tat ttt att ggt ctc       1200
Leu Ala Gly Val Leu Ile Leu Val Leu Leu Ala Tyr Phe Ile Gly Leu           
385                 390                 395                 400           

aag cac cat cat gct gga tat gag caa ttt tag                           1233
Lys His His His Ala Gly Tyr Glu Gln Phe                                   
                405                 410                                   


<210>  26
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu 
1               5                   10                  15      


Val Cys Leu Val Leu Gly Ala Val Arg Ser Tyr Ala Leu Glu Leu Asn 
            20                  25                  30          


Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met 
        35                  40                  45              


Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr Val 
    50                  55                  60                  


Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys Gly 
65                  70                  75                  80  


Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly Phe 
                85                  90                  95      


Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile Asp 
            100                 105                 110         


Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp 
        115                 120                 125             


Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile Arg 
    130                 135                 140                 


Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu 
145                 150                 155                 160 


Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala Phe 
                165                 170                 175     


Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys Asp 
            180                 185                 190         


Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser Pro 
        195                 200                 205             


Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr Ser 
    210                 215                 220                 


Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu Gln 
225                 230                 235                 240 


Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn Pro 
                245                 250                 255     


Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu Leu 
            260                 265                 270         


Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala Val 
        275                 280                 285             


Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met Tyr 
    290                 295                 300                 


Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser Tyr 
305                 310                 315                 320 


Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr 
                325                 330                 335     


Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg Val 
            340                 345                 350         


Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Asp Cys 
        355                 360                 365             


Ser Ala Asp Asp Asp Asn Phe Leu Val Pro Ile Ala Val Gly Ala Ala 
    370                 375                 380                 


Leu Ala Gly Val Leu Ile Leu Val Leu Leu Ala Tyr Phe Ile Gly Leu 
385                 390                 395                 400 


Lys His His His Ala Gly Tyr Glu Gln Phe 
                405                 410 


<210>  27
<211>  1233
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1233)

<400>  27
atg gtg tgc ttc cgc ctc ttc ccg gtt ccg ggc tca ggg ctc gtt ctg         48
Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu           
1               5                   10                  15                

gtc tgc cta gtc ctg gga gct gtg cgg tct tat gca ttg gaa ctt aat         96
Val Cys Leu Val Leu Gly Ala Val Arg Ser Tyr Ala Leu Glu Leu Asn           
            20                  25                  30                    

ttg aca gat tca gaa aat gcc act tgc ctt tat gca aaa tgg cag atg        144
Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met           
        35                  40                  45                        

aat ttc aca gta cgc tat gaa act aca aat aaa act tat aaa act gta        192
Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr Val           
    50                  55                  60                            

acc att tca gac cat ggc act gtg aca tat aat gga agc att tgt ggg        240
Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys Gly           
65                  70                  75                  80            

gat gat cag aat ggt ccc aaa ata gca gtg cag ttc gga cct ggc ttt        288
Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly Phe           
                85                  90                  95                

tcc tgg att gcg aat ttt acc aag gca gca tct act tat tca att gac        336
Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile Asp           
            100                 105                 110                   

agc gtc tca ttt tcc tac aac act ggt gat aac aca aca ttt cct gat        384
Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp           
        115                 120                 125                       

gct gaa gat aaa gga att ctt act gtt gat gaa ctt ttg gcc atc aga        432
Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile Arg           
    130                 135                 140                           

att cca ttg aat gac ctt ttt aga tgc aat agt tta tca act ttg gaa        480
Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu           
145                 150                 155                 160           

aag aat gat gtt gtc caa cac tac tgg gat gtt ctt gta caa gct ttt        528
Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala Phe           
                165                 170                 175               

gtc caa aat ggc aca gtg agc aca aat gag ttc ctg tgt gat aaa gac        576
Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys Asp           
            180                 185                 190                   

aaa act tca aca gtg gca ccc acc ata cac acc act gtg cca tct cct        624
Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser Pro           
        195                 200                 205                       

act aca aca cct act cca aag gaa aaa cca gaa gct gga acc tat tca        672
Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr Ser           
    210                 215                 220                           

gtt aat aat ggc aat gat act tgt ctg ctg gct acc atg ggg ctg cag        720
Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu Gln           
225                 230                 235                 240           

ctg aac atc act cag gat aag gtt gct tca gtt att aac atc aac ccc        768
Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn Pro           
                245                 250                 255               

aat aca act cac tcc aca ggc agc tgc cgt tct cac act gct cta ctt        816
Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu Leu           
            260                 265                 270                   

aga ctc aat agc agc acc att aag tat cta gac ttt gtc ttt gct gtg        864
Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala Val           
        275                 280                 285                       

aaa aat gaa aac cga ttt tat ctg aag gaa gtg aac atc agc atg tat        912
Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met Tyr           
    290                 295                 300                           

ttg gtt aat ggc tcc gtt ttc agc att gca aat aac aat ctc agc tac        960
Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser Tyr           
305                 310                 315                 320           

tgg gat gcc ccc ctg gga agt tct tat atg tgc aac aaa gag cag act       1008
Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr           
                325                 330                 335               

gtt tca gtg tct gga gca ttt cag ata aat acc ttt gat cta agg gtt       1056
Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg Val           
            340                 345                 350                   

cag cct ttc aat gtg aca caa gga aag tat tct aca gcc caa gag tgt       1104
Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Glu Cys           
        355                 360                 365                       

tcg ctg gat gat gac acc att cta atc cca att ata gtt ggt gct ggt       1152
Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile Val Gly Ala Gly           
    370                 375                 380                           

ctt tca ggc ttg att atc gtt ata gtg att gct tac gta att ggc aga       1200
Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Tyr Val Ile Gly Arg           
385                 390                 395                 400           

aga aaa agt tat gct gga tat cag act ctg taa                           1233
Arg Lys Ser Tyr Ala Gly Tyr Gln Thr Leu                                   
                405                 410                                   


<210>  28
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu 
1               5                   10                  15      


Val Cys Leu Val Leu Gly Ala Val Arg Ser Tyr Ala Leu Glu Leu Asn 
            20                  25                  30          


Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met 
        35                  40                  45              


Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr Val 
    50                  55                  60                  


Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys Gly 
65                  70                  75                  80  


Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly Phe 
                85                  90                  95      


Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile Asp 
            100                 105                 110         


Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp 
        115                 120                 125             


Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile Arg 
    130                 135                 140                 


Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu 
145                 150                 155                 160 


Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala Phe 
                165                 170                 175     


Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys Asp 
            180                 185                 190         


Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser Pro 
        195                 200                 205             


Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr Ser 
    210                 215                 220                 


Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu Gln 
225                 230                 235                 240 


Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn Pro 
                245                 250                 255     


Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu Leu 
            260                 265                 270         


Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala Val 
        275                 280                 285             


Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met Tyr 
    290                 295                 300                 


Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser Tyr 
305                 310                 315                 320 


Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr 
                325                 330                 335     


Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg Val 
            340                 345                 350         


Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Glu Cys 
        355                 360                 365             


Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile Val Gly Ala Gly 
    370                 375                 380                 


Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Tyr Val Ile Gly Arg 
385                 390                 395                 400 


Arg Lys Ser Tyr Ala Gly Tyr Gln Thr Leu 
                405                 410 


<210>  29
<211>  1236
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1236)

<400>  29
atg gtg tgc ttc cgc ctc ttc ccg gtt ccg ggc tca ggg ctc gtt ctg         48
Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu           
1               5                   10                  15                

gtc tgc cta gtc ctg gga gct gtg cgg tct tat gca ttg gaa ctt aat         96
Val Cys Leu Val Leu Gly Ala Val Arg Ser Tyr Ala Leu Glu Leu Asn           
            20                  25                  30                    

ttg aca gat tca gaa aat gcc act tgc ctt tat gca aaa tgg cag atg        144
Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met           
        35                  40                  45                        

aat ttc aca gta cgc tat gaa act aca aat aaa act tat aaa act gta        192
Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr Val           
    50                  55                  60                            

acc att tca gac cat ggc act gtg aca tat aat gga agc att tgt ggg        240
Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys Gly           
65                  70                  75                  80            

gat gat cag aat ggt ccc aaa ata gca gtg cag ttc gga cct ggc ttt        288
Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly Phe           
                85                  90                  95                

tcc tgg att gcg aat ttt acc aag gca gca tct act tat tca att gac        336
Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile Asp           
            100                 105                 110                   

agc gtc tca ttt tcc tac aac act ggt gat aac aca aca ttt cct gat        384
Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp           
        115                 120                 125                       

gct gaa gat aaa gga att ctt act gtt gat gaa ctt ttg gcc atc aga        432
Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile Arg           
    130                 135                 140                           

att cca ttg aat gac ctt ttt aga tgc aat agt tta tca act ttg gaa        480
Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu           
145                 150                 155                 160           

aag aat gat gtt gtc caa cac tac tgg gat gtt ctt gta caa gct ttt        528
Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala Phe           
                165                 170                 175               

gtc caa aat ggc aca gtg agc aca aat gag ttc ctg tgt gat aaa gac        576
Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys Asp           
            180                 185                 190                   

aaa act tca aca gtg gca ccc acc ata cac acc act gtg cca tct cct        624
Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser Pro           
        195                 200                 205                       

act aca aca cct act cca aag gaa aaa cca gaa gct gga acc tat tca        672
Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr Ser           
    210                 215                 220                           

gtt aat aat ggc aat gat act tgt ctg ctg gct acc atg ggg ctg cag        720
Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu Gln           
225                 230                 235                 240           

ctg aac atc act cag gat aag gtt gct tca gtt att aac atc aac ccc        768
Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn Pro           
                245                 250                 255               

aat aca act cac tcc aca ggc agc tgc cgt tct cac act gct cta ctt        816
Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu Leu           
            260                 265                 270                   

aga ctc aat agc agc acc att aag tat cta gac ttt gtc ttt gct gtg        864
Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala Val           
        275                 280                 285                       

aaa aat gaa aac cga ttt tat ctg aag gaa gtg aac atc agc atg tat        912
Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met Tyr           
    290                 295                 300                           

ttg gtt aat ggc tcc gtt ttc agc att gca aat aac aat ctc agc tac        960
Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser Tyr           
305                 310                 315                 320           

tgg gat gcc ccc ctg gga agt tct tat atg tgc aac aaa gag cag act       1008
Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr           
                325                 330                 335               

gtt tca gtg tct gga gca ttt cag ata aat acc ttt gat cta agg gtt       1056
Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg Val           
            340                 345                 350                   

cag cct ttc aat gtg aca caa gga aag tat tct aca gct gaa gaa tgt       1104
Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Glu Glu Cys           
        355                 360                 365                       

tct gct gac tct gac ctc aac ttt ctt att cct gtt gca gtg ggt gtg       1152
Ser Ala Asp Ser Asp Leu Asn Phe Leu Ile Pro Val Ala Val Gly Val           
    370                 375                 380                           

gcc ttg ggc ttc ctt ata att gtt gtc ttt atc tct tat atg att gga       1200
Ala Leu Gly Phe Leu Ile Ile Val Val Phe Ile Ser Tyr Met Ile Gly           
385                 390                 395                 400           

aga agg aaa agt cgt act ggt tat cag tct gtg taa                       1236
Arg Arg Lys Ser Arg Thr Gly Tyr Gln Ser Val                               
                405                 410                                   


<210>  30
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu 
1               5                   10                  15      


Val Cys Leu Val Leu Gly Ala Val Arg Ser Tyr Ala Leu Glu Leu Asn 
            20                  25                  30          


Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met 
        35                  40                  45              


Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr Val 
    50                  55                  60                  


Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys Gly 
65                  70                  75                  80  


Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly Phe 
                85                  90                  95      


Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile Asp 
            100                 105                 110         


Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp 
        115                 120                 125             


Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile Arg 
    130                 135                 140                 


Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu 
145                 150                 155                 160 


Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala Phe 
                165                 170                 175     


Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys Asp 
            180                 185                 190         


Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser Pro 
        195                 200                 205             


Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr Ser 
    210                 215                 220                 


Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu Gln 
225                 230                 235                 240 


Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn Pro 
                245                 250                 255     


Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu Leu 
            260                 265                 270         


Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala Val 
        275                 280                 285             


Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met Tyr 
    290                 295                 300                 


Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser Tyr 
305                 310                 315                 320 


Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr 
                325                 330                 335     


Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg Val 
            340                 345                 350         


Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Glu Glu Cys 
        355                 360                 365             


Ser Ala Asp Ser Asp Leu Asn Phe Leu Ile Pro Val Ala Val Gly Val 
    370                 375                 380                 


Ala Leu Gly Phe Leu Ile Ile Val Val Phe Ile Ser Tyr Met Ile Gly 
385                 390                 395                 400 


Arg Arg Lys Ser Arg Thr Gly Tyr Gln Ser Val 
                405                 410     


<210>  31
<211>  1347
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1347)

<400>  31
atg atc ccc acc ttc acg gct ctg ctc tgc ctc ggg ctg agt ctg ggc         48
Met Ile Pro Thr Phe Thr Ala Leu Leu Cys Leu Gly Leu Ser Leu Gly           
1               5                   10                  15                

ccc agg acc cac atg cag gca ggg ccc ctc ccc aaa ccc acc ctc tgg         96
Pro Arg Thr His Met Gln Ala Gly Pro Leu Pro Lys Pro Thr Leu Trp           
            20                  25                  30                    

gct gag cca ggc tct gtg atc agc tgg ggg aac tct gtg acc atc tgg        144
Ala Glu Pro Gly Ser Val Ile Ser Trp Gly Asn Ser Val Thr Ile Trp           
        35                  40                  45                        

tgt cag ggg acc ctg gag gct cgg gag tac cgt ctg gat aaa gag gaa        192
Cys Gln Gly Thr Leu Glu Ala Arg Glu Tyr Arg Leu Asp Lys Glu Glu           
    50                  55                  60                            

agc cca gca ccc tgg gac aga cag aac cca ctg gag ccc aag aac aag        240
Ser Pro Ala Pro Trp Asp Arg Gln Asn Pro Leu Glu Pro Lys Asn Lys           
65                  70                  75                  80            

gcc aga ttc tcc atc cca tcc atg aca gag gac tat gca ggg aga tac        288
Ala Arg Phe Ser Ile Pro Ser Met Thr Glu Asp Tyr Ala Gly Arg Tyr           
                85                  90                  95                

cgc tgt tac tat cgc agc cct gta ggc tgg tca cag ccc agt gac ccc        336
Arg Cys Tyr Tyr Arg Ser Pro Val Gly Trp Ser Gln Pro Ser Asp Pro           
            100                 105                 110                   

ctg gag ctg gtg atg aca gga gcc tac agt aaa ccc acc ctt tca gcc        384
Leu Glu Leu Val Met Thr Gly Ala Tyr Ser Lys Pro Thr Leu Ser Ala           
        115                 120                 125                       

ctg ccg agt cct ctt gtg acc tca gga aag agc gtg acc ctg ctg tgt        432
Leu Pro Ser Pro Leu Val Thr Ser Gly Lys Ser Val Thr Leu Leu Cys           
    130                 135                 140                           

cag tca cgg agc cca atg gac act ttt ctt ctg atc aag gag cgg gca        480
Gln Ser Arg Ser Pro Met Asp Thr Phe Leu Leu Ile Lys Glu Arg Ala           
145                 150                 155                 160           

gcc cat ccc cta ctg cat ctg aga tca gag cac gga gct cag cag cac        528
Ala His Pro Leu Leu His Leu Arg Ser Glu His Gly Ala Gln Gln His           
                165                 170                 175               

cag gct gaa ttc ccc atg agt cct gtg acc tca gtg cac ggg ggg acc        576
Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser Val His Gly Gly Thr           
            180                 185                 190                   

tac agg tgc ttc agc tca cac ggc ttc tcc cac tac ctg ctg tca cac        624
Tyr Arg Cys Phe Ser Ser His Gly Phe Ser His Tyr Leu Leu Ser His           
        195                 200                 205                       

ccc agt gac ccc ctg gag ctc ata gtc tca gga tcc ttg gag ggt ccc        672
Pro Ser Asp Pro Leu Glu Leu Ile Val Ser Gly Ser Leu Glu Gly Pro           
    210                 215                 220                           

agg ccc tca ccc aca agg tcc gtc tca aca gct gca ggc cct gag gac        720
Arg Pro Ser Pro Thr Arg Ser Val Ser Thr Ala Ala Gly Pro Glu Asp           
225                 230                 235                 240           

cag ccc ctc atg cct aca ggg tca gtc ccc cac agt ggt ctg aga agg        768
Gln Pro Leu Met Pro Thr Gly Ser Val Pro His Ser Gly Leu Arg Arg           
                245                 250                 255               

cac tgg gag gta ctg atc ggg gtc ttg gtg gtc tcc atc ctg ctt ctc        816
His Trp Glu Val Leu Ile Gly Val Leu Val Val Ser Ile Leu Leu Leu           
            260                 265                 270                   

tcc ctc ctc ctc ttc ctc ctc ctc caa cac tgg cgt cag gga aaa cac        864
Ser Leu Leu Leu Phe Leu Leu Leu Gln His Trp Arg Gln Gly Lys His           
        275                 280                 285                       

agg aca ttg gcc cag aga cag gct gat ttc caa cgt cct cca ggg gct        912
Arg Thr Leu Ala Gln Arg Gln Ala Asp Phe Gln Arg Pro Pro Gly Ala           
    290                 295                 300                           

gcc gag cca gag ccc aag gac ggg ggc cta cag agg agg tcc agc cca        960
Ala Glu Pro Glu Pro Lys Asp Gly Gly Leu Gln Arg Arg Ser Ser Pro           
305                 310                 315                 320           

gct gct gac gtc cag gga gaa aac ttc tgt gct gcc gtg aag aac aca       1008
Ala Ala Asp Val Gln Gly Glu Asn Phe Cys Ala Ala Val Lys Asn Thr           
                325                 330                 335               

cag cct gag gac ggg gtg gaa atg gac act cgg cag agc cca cac gat       1056
Gln Pro Glu Asp Gly Val Glu Met Asp Thr Arg Gln Ser Pro His Asp           
            340                 345                 350                   

gaa gac ccc cag gca gtg acg tat gcc aag gtg aaa cac tcc aga cct       1104
Glu Asp Pro Gln Ala Val Thr Tyr Ala Lys Val Lys His Ser Arg Pro           
        355                 360                 365                       

agg aga gaa atg gcc tct cct ccc tcc cca ctg tct ggg gaa ttc ctg       1152
Arg Arg Glu Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu           
    370                 375                 380                           

gac aca aag gac aga cag gca gaa gag gac aga cag atg gac act gag       1200
Asp Thr Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu           
385                 390                 395                 400           

gct gct gca tct gaa gcc ccc cag gat gtg acc tac gcc cgg ctg cac       1248
Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Arg Leu His           
                405                 410                 415               

agc ttt acc ctc aga cag aag gca act gag cct cct cca tcc cag gaa       1296
Ser Phe Thr Leu Arg Gln Lys Ala Thr Glu Pro Pro Pro Ser Gln Glu           
            420                 425                 430                   

ggg gcc tct cca gct gag ccc agt gtc tat gcc act ctg gcc atc cac       1344
Gly Ala Ser Pro Ala Glu Pro Ser Val Tyr Ala Thr Leu Ala Ile His           
        435                 440                 445                       

taa                                                                   1347


<210>  32
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ile Pro Thr Phe Thr Ala Leu Leu Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Met Gln Ala Gly Pro Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ser Trp Gly Asn Ser Val Thr Ile Trp 
        35                  40                  45              


Cys Gln Gly Thr Leu Glu Ala Arg Glu Tyr Arg Leu Asp Lys Glu Glu 
    50                  55                  60                  


Ser Pro Ala Pro Trp Asp Arg Gln Asn Pro Leu Glu Pro Lys Asn Lys 
65                  70                  75                  80  


Ala Arg Phe Ser Ile Pro Ser Met Thr Glu Asp Tyr Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys Tyr Tyr Arg Ser Pro Val Gly Trp Ser Gln Pro Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Val Met Thr Gly Ala Tyr Ser Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Leu Pro Ser Pro Leu Val Thr Ser Gly Lys Ser Val Thr Leu Leu Cys 
    130                 135                 140                 


Gln Ser Arg Ser Pro Met Asp Thr Phe Leu Leu Ile Lys Glu Arg Ala 
145                 150                 155                 160 


Ala His Pro Leu Leu His Leu Arg Ser Glu His Gly Ala Gln Gln His 
                165                 170                 175     


Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser Val His Gly Gly Thr 
            180                 185                 190         


Tyr Arg Cys Phe Ser Ser His Gly Phe Ser His Tyr Leu Leu Ser His 
        195                 200                 205             


Pro Ser Asp Pro Leu Glu Leu Ile Val Ser Gly Ser Leu Glu Gly Pro 
    210                 215                 220                 


Arg Pro Ser Pro Thr Arg Ser Val Ser Thr Ala Ala Gly Pro Glu Asp 
225                 230                 235                 240 


Gln Pro Leu Met Pro Thr Gly Ser Val Pro His Ser Gly Leu Arg Arg 
                245                 250                 255     


His Trp Glu Val Leu Ile Gly Val Leu Val Val Ser Ile Leu Leu Leu 
            260                 265                 270         


Ser Leu Leu Leu Phe Leu Leu Leu Gln His Trp Arg Gln Gly Lys His 
        275                 280                 285             


Arg Thr Leu Ala Gln Arg Gln Ala Asp Phe Gln Arg Pro Pro Gly Ala 
    290                 295                 300                 


Ala Glu Pro Glu Pro Lys Asp Gly Gly Leu Gln Arg Arg Ser Ser Pro 
305                 310                 315                 320 


Ala Ala Asp Val Gln Gly Glu Asn Phe Cys Ala Ala Val Lys Asn Thr 
                325                 330                 335     


Gln Pro Glu Asp Gly Val Glu Met Asp Thr Arg Gln Ser Pro His Asp 
            340                 345                 350         


Glu Asp Pro Gln Ala Val Thr Tyr Ala Lys Val Lys His Ser Arg Pro 
        355                 360                 365             


Arg Arg Glu Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu 
    370                 375                 380                 


Asp Thr Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu 
385                 390                 395                 400 


Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Arg Leu His 
                405                 410                 415     


Ser Phe Thr Leu Arg Gln Lys Ala Thr Glu Pro Pro Pro Ser Gln Glu 
            420                 425                 430         


Gly Ala Ser Pro Ala Glu Pro Ser Val Tyr Ala Thr Leu Ala Ile His 
        435                 440                 445             


<210>  33
<211>  1347
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1347)

<400>  33
atg atc ccc acc ttc acg gct ctg ctc tgc ctc ggg ctg agt ctg ggc         48
Met Ile Pro Thr Phe Thr Ala Leu Leu Cys Leu Gly Leu Ser Leu Gly           
1               5                   10                  15                

ccc agg acc cac atg cag gca ggg ccc ctc ccc aaa ccc acc ctc tgg         96
Pro Arg Thr His Met Gln Ala Gly Pro Leu Pro Lys Pro Thr Leu Trp           
            20                  25                  30                    

gct gag cca ggc tct gtg atc agc tgg ggg aac tct gtg acc atc tgg        144
Ala Glu Pro Gly Ser Val Ile Ser Trp Gly Asn Ser Val Thr Ile Trp           
        35                  40                  45                        

tgt cag ggg acc ctg gag gct cgg gag tac cgt ctg gat aaa gag gaa        192
Cys Gln Gly Thr Leu Glu Ala Arg Glu Tyr Arg Leu Asp Lys Glu Glu           
    50                  55                  60                            

agc cca gca ccc tgg gac aga cag aac cca ctg gag ccc aag aac aag        240
Ser Pro Ala Pro Trp Asp Arg Gln Asn Pro Leu Glu Pro Lys Asn Lys           
65                  70                  75                  80            

gcc aga ttc tcc atc cca tcc atg aca gag gac tat gca ggg aga tac        288
Ala Arg Phe Ser Ile Pro Ser Met Thr Glu Asp Tyr Ala Gly Arg Tyr           
                85                  90                  95                

cgc tgt tac tat cgc agc cct gta ggc tgg tca cag ccc agt gac ccc        336
Arg Cys Tyr Tyr Arg Ser Pro Val Gly Trp Ser Gln Pro Ser Asp Pro           
            100                 105                 110                   

ctg gag ctg gtg atg aca gga gcc tac agt aaa ccc acc ctt tca gcc        384
Leu Glu Leu Val Met Thr Gly Ala Tyr Ser Lys Pro Thr Leu Ser Ala           
        115                 120                 125                       

ctg ccg agt cct ctt gtg acc tca gga aag agc gtg acc ctg ctg tgt        432
Leu Pro Ser Pro Leu Val Thr Ser Gly Lys Ser Val Thr Leu Leu Cys           
    130                 135                 140                           

cag tca cgg agc cca atg gac act ttc ctt ctg atc aag gag cgg gca        480
Gln Ser Arg Ser Pro Met Asp Thr Phe Leu Leu Ile Lys Glu Arg Ala           
145                 150                 155                 160           

gcc cat ccc cta ctg cat ctg aga tca gag cac gga gct cag cag cac        528
Ala His Pro Leu Leu His Leu Arg Ser Glu His Gly Ala Gln Gln His           
                165                 170                 175               

cag gct gaa ttc ccc atg agt cct gtg acc tca gtg cac ggg ggg acc        576
Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser Val His Gly Gly Thr           
            180                 185                 190                   

tac agg tgc ttc agc tca cac ggc ttc tcc cac tac ctg ctg tca cac        624
Tyr Arg Cys Phe Ser Ser His Gly Phe Ser His Tyr Leu Leu Ser His           
        195                 200                 205                       

ccc agt gac ccc ctg gag ctc ata gtc tca gga tcc ttg gag gat ccc        672
Pro Ser Asp Pro Leu Glu Leu Ile Val Ser Gly Ser Leu Glu Asp Pro           
    210                 215                 220                           

agg ccc tca ccc aca agg tcc gtc tca aca gct gca ggc cct gag gac        720
Arg Pro Ser Pro Thr Arg Ser Val Ser Thr Ala Ala Gly Pro Glu Asp           
225                 230                 235                 240           

cag ccc ctc atg cct aca ggg tca gtc ccc cac agt ggt ctg aga agg        768
Gln Pro Leu Met Pro Thr Gly Ser Val Pro His Ser Gly Leu Arg Arg           
                245                 250                 255               

cac tgg gag gta ctg atc ggg gtc ttg gtg gtc tcc atc ctg ctt ctc        816
His Trp Glu Val Leu Ile Gly Val Leu Val Val Ser Ile Leu Leu Leu           
            260                 265                 270                   

tcc ctc ctc ctc ttc ctc ctc ctc caa cac tgg cgt cag gga aaa cac        864
Ser Leu Leu Leu Phe Leu Leu Leu Gln His Trp Arg Gln Gly Lys His           
        275                 280                 285                       

agg aca ttg gcc cag aga cag gct gat ttc caa cgt cct cca ggg gct        912
Arg Thr Leu Ala Gln Arg Gln Ala Asp Phe Gln Arg Pro Pro Gly Ala           
    290                 295                 300                           

gcc gag cca gag ccc aag gac ggg ggc cta cag agg agg tcc agc cca        960
Ala Glu Pro Glu Pro Lys Asp Gly Gly Leu Gln Arg Arg Ser Ser Pro           
305                 310                 315                 320           

gct gct gac gtc cag gga gaa aac ttc tgt gct gcc gtg aag aac aca       1008
Ala Ala Asp Val Gln Gly Glu Asn Phe Cys Ala Ala Val Lys Asn Thr           
                325                 330                 335               

cag cct gag gac ggg gtg gaa atg gac act cgg cag agc cca cac gat       1056
Gln Pro Glu Asp Gly Val Glu Met Asp Thr Arg Gln Ser Pro His Asp           
            340                 345                 350                   

gaa gac ccc cag gca gtg acg tat gcc aag gtg aaa cac tcc aga cct       1104
Glu Asp Pro Gln Ala Val Thr Tyr Ala Lys Val Lys His Ser Arg Pro           
        355                 360                 365                       

agg aga gaa atg gcc tct cct ccc tcc cca ctg tct ggg gaa ttc ctg       1152
Arg Arg Glu Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu           
    370                 375                 380                           

gac aca aag gac aga cag gca gaa gag gac aga cag atg gac act gag       1200
Asp Thr Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu           
385                 390                 395                 400           

gct gct gca tct gaa gcc ccc cag gat gtg acc tac gcc cag ctg cac       1248
Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His           
                405                 410                 415               

agc ttt acc ctc aga cag aag gca act gag cct cct cca tcc cag gaa       1296
Ser Phe Thr Leu Arg Gln Lys Ala Thr Glu Pro Pro Pro Ser Gln Glu           
            420                 425                 430                   

ggg gcc tct cca gct gag ccc agt gtc tat gcc act ctg gcc atc cac       1344
Gly Ala Ser Pro Ala Glu Pro Ser Val Tyr Ala Thr Leu Ala Ile His           
        435                 440                 445                       

taa                                                                   1347


<210>  34
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ile Pro Thr Phe Thr Ala Leu Leu Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Met Gln Ala Gly Pro Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ser Trp Gly Asn Ser Val Thr Ile Trp 
        35                  40                  45              


Cys Gln Gly Thr Leu Glu Ala Arg Glu Tyr Arg Leu Asp Lys Glu Glu 
    50                  55                  60                  


Ser Pro Ala Pro Trp Asp Arg Gln Asn Pro Leu Glu Pro Lys Asn Lys 
65                  70                  75                  80  


Ala Arg Phe Ser Ile Pro Ser Met Thr Glu Asp Tyr Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys Tyr Tyr Arg Ser Pro Val Gly Trp Ser Gln Pro Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Val Met Thr Gly Ala Tyr Ser Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Leu Pro Ser Pro Leu Val Thr Ser Gly Lys Ser Val Thr Leu Leu Cys 
    130                 135                 140                 


Gln Ser Arg Ser Pro Met Asp Thr Phe Leu Leu Ile Lys Glu Arg Ala 
145                 150                 155                 160 


Ala His Pro Leu Leu His Leu Arg Ser Glu His Gly Ala Gln Gln His 
                165                 170                 175     


Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser Val His Gly Gly Thr 
            180                 185                 190         


Tyr Arg Cys Phe Ser Ser His Gly Phe Ser His Tyr Leu Leu Ser His 
        195                 200                 205             


Pro Ser Asp Pro Leu Glu Leu Ile Val Ser Gly Ser Leu Glu Asp Pro 
    210                 215                 220                 


Arg Pro Ser Pro Thr Arg Ser Val Ser Thr Ala Ala Gly Pro Glu Asp 
225                 230                 235                 240 


Gln Pro Leu Met Pro Thr Gly Ser Val Pro His Ser Gly Leu Arg Arg 
                245                 250                 255     


His Trp Glu Val Leu Ile Gly Val Leu Val Val Ser Ile Leu Leu Leu 
            260                 265                 270         


Ser Leu Leu Leu Phe Leu Leu Leu Gln His Trp Arg Gln Gly Lys His 
        275                 280                 285             


Arg Thr Leu Ala Gln Arg Gln Ala Asp Phe Gln Arg Pro Pro Gly Ala 
    290                 295                 300                 


Ala Glu Pro Glu Pro Lys Asp Gly Gly Leu Gln Arg Arg Ser Ser Pro 
305                 310                 315                 320 


Ala Ala Asp Val Gln Gly Glu Asn Phe Cys Ala Ala Val Lys Asn Thr 
                325                 330                 335     


Gln Pro Glu Asp Gly Val Glu Met Asp Thr Arg Gln Ser Pro His Asp 
            340                 345                 350         


Glu Asp Pro Gln Ala Val Thr Tyr Ala Lys Val Lys His Ser Arg Pro 
        355                 360                 365             


Arg Arg Glu Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu 
    370                 375                 380                 


Asp Thr Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu 
385                 390                 395                 400 


Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His 
                405                 410                 415     


Ser Phe Thr Leu Arg Gln Lys Ala Thr Glu Pro Pro Pro Ser Gln Glu 
            420                 425                 430         


Gly Ala Ser Pro Ala Glu Pro Ser Val Tyr Ala Thr Leu Ala Ile His 
        435                 440                 445             


<210>  35
<211>  1350
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1350)

<400>  35
atg atc ccc acc ttc acg gct ctg ctc tgc ctc ggg ctg agt ctg ggc         48
Met Ile Pro Thr Phe Thr Ala Leu Leu Cys Leu Gly Leu Ser Leu Gly           
1               5                   10                  15                

ccc agg acc cac atg cag gca ggg ccc ctc ccc aaa ccc acc ctc tgg         96
Pro Arg Thr His Met Gln Ala Gly Pro Leu Pro Lys Pro Thr Leu Trp           
            20                  25                  30                    

gct gag cca ggc tct gtg atc agc tgg ggg aac tct gtg acc atc tgg        144
Ala Glu Pro Gly Ser Val Ile Ser Trp Gly Asn Ser Val Thr Ile Trp           
        35                  40                  45                        

tgt cag ggg acc ctg gag gct cgg gag tac cgt ctg gat aaa gag gaa        192
Cys Gln Gly Thr Leu Glu Ala Arg Glu Tyr Arg Leu Asp Lys Glu Glu           
    50                  55                  60                            

agc cca gca ccc tgg gac aga cag aac cca ctg gag ccc aag aac aag        240
Ser Pro Ala Pro Trp Asp Arg Gln Asn Pro Leu Glu Pro Lys Asn Lys           
65                  70                  75                  80            

gcc aga ttc tcc atc cca tcc atg aca gag gac tat gca ggg aga tac        288
Ala Arg Phe Ser Ile Pro Ser Met Thr Glu Asp Tyr Ala Gly Arg Tyr           
                85                  90                  95                

cgc tgt tac tat cgc agc cct gta ggc tgg tca cag ccc agt gac ccc        336
Arg Cys Tyr Tyr Arg Ser Pro Val Gly Trp Ser Gln Pro Ser Asp Pro           
            100                 105                 110                   

ctg gag ctg gtg atg aca gga gcc tac agt aaa ccc acc ctt tca gcc        384
Leu Glu Leu Val Met Thr Gly Ala Tyr Ser Lys Pro Thr Leu Ser Ala           
        115                 120                 125                       

ctg ccg agt cct ctt gtg acc tca gga aag agc gtg acc ctg ctg tgt        432
Leu Pro Ser Pro Leu Val Thr Ser Gly Lys Ser Val Thr Leu Leu Cys           
    130                 135                 140                           

cag tca cgg agc cca atg gac act ttc ctt ctg atc aag gag cgg gca        480
Gln Ser Arg Ser Pro Met Asp Thr Phe Leu Leu Ile Lys Glu Arg Ala           
145                 150                 155                 160           

gcc cat ccc cta ctg cat ctg aga tca gag cac gga gct cag cag cac        528
Ala His Pro Leu Leu His Leu Arg Ser Glu His Gly Ala Gln Gln His           
                165                 170                 175               

cag gct gaa ttc ccc atg agt cct gtg acc tca gtg cac ggg ggg acc        576
Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser Val His Gly Gly Thr           
            180                 185                 190                   

tac agg tgc ttc agc tca cac ggc ttc tcc cac tac ctg ctg tca cac        624
Tyr Arg Cys Phe Ser Ser His Gly Phe Ser His Tyr Leu Leu Ser His           
        195                 200                 205                       

ccc agt gac ccc ctg gag ctc ata gtc tca gga tcc ttg gag gat ccc        672
Pro Ser Asp Pro Leu Glu Leu Ile Val Ser Gly Ser Leu Glu Asp Pro           
    210                 215                 220                           

agg ccc tca ccc aca agg tcc gtc tca aca gct gca ggc cct gag gac        720
Arg Pro Ser Pro Thr Arg Ser Val Ser Thr Ala Ala Gly Pro Glu Asp           
225                 230                 235                 240           

cag ccc ctc atg cct aca ggg tca gtc ccc cac agt ggt ctg aga agg        768
Gln Pro Leu Met Pro Thr Gly Ser Val Pro His Ser Gly Leu Arg Arg           
                245                 250                 255               

cac tgg gag gta ctg atc ggg gtc ttg gtg gtc tcc atc ctg ctt ctc        816
His Trp Glu Val Leu Ile Gly Val Leu Val Val Ser Ile Leu Leu Leu           
            260                 265                 270                   

tcc ctc ctc ctc ttc ctc ctc ctc caa cac tgg cgt cag gga aaa cac        864
Ser Leu Leu Leu Phe Leu Leu Leu Gln His Trp Arg Gln Gly Lys His           
        275                 280                 285                       

agg aca ttg gcc cag aga cag gct gat ttc caa cgt cct cca ggg gct        912
Arg Thr Leu Ala Gln Arg Gln Ala Asp Phe Gln Arg Pro Pro Gly Ala           
    290                 295                 300                           

gcc gag cca gag ccc aag gac ggg ggc cta cag agg agg tcc agc cca        960
Ala Glu Pro Glu Pro Lys Asp Gly Gly Leu Gln Arg Arg Ser Ser Pro           
305                 310                 315                 320           

gct gct gac gtc cag gga gaa aac ttc tca ggt gct gcc gtg aag aac       1008
Ala Ala Asp Val Gln Gly Glu Asn Phe Ser Gly Ala Ala Val Lys Asn           
                325                 330                 335               

aca cag cct gag gac ggg gtg gaa atg gac act cgg cag agc cca cac       1056
Thr Gln Pro Glu Asp Gly Val Glu Met Asp Thr Arg Gln Ser Pro His           
            340                 345                 350                   

gat gaa gac ccc cag gca gtg acg tat gcc aag gtg aaa cac tcc aga       1104
Asp Glu Asp Pro Gln Ala Val Thr Tyr Ala Lys Val Lys His Ser Arg           
        355                 360                 365                       

cct agg aga gaa atg gcc tct cct ccc tcc cca ctg tct ggg gaa ttc       1152
Pro Arg Arg Glu Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe           
    370                 375                 380                           

ctg gac aca aag gac aga cag gca gaa gag gac aga cag atg gac act       1200
Leu Asp Thr Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp Thr           
385                 390                 395                 400           

gag gct gct gca tct gaa gcc ccc cag gat gtg acc tac gcc cag ctg       1248
Glu Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu           
                405                 410                 415               

cac agc ttt acc ctc aga cag aag gca act gag cct cct cca tcc cag       1296
His Ser Phe Thr Leu Arg Gln Lys Ala Thr Glu Pro Pro Pro Ser Gln           
            420                 425                 430                   

gaa ggg gcc tct cca gct gag ccc agt gtc tat gcc act ctg gcc atc       1344
Glu Gly Ala Ser Pro Ala Glu Pro Ser Val Tyr Ala Thr Leu Ala Ile           
        435                 440                 445                       

cac taa                                                               1350
His                                                                       
                                                                          


<210>  36
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ile Pro Thr Phe Thr Ala Leu Leu Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Met Gln Ala Gly Pro Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ser Trp Gly Asn Ser Val Thr Ile Trp 
        35                  40                  45              


Cys Gln Gly Thr Leu Glu Ala Arg Glu Tyr Arg Leu Asp Lys Glu Glu 
    50                  55                  60                  


Ser Pro Ala Pro Trp Asp Arg Gln Asn Pro Leu Glu Pro Lys Asn Lys 
65                  70                  75                  80  


Ala Arg Phe Ser Ile Pro Ser Met Thr Glu Asp Tyr Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys Tyr Tyr Arg Ser Pro Val Gly Trp Ser Gln Pro Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Val Met Thr Gly Ala Tyr Ser Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Leu Pro Ser Pro Leu Val Thr Ser Gly Lys Ser Val Thr Leu Leu Cys 
    130                 135                 140                 


Gln Ser Arg Ser Pro Met Asp Thr Phe Leu Leu Ile Lys Glu Arg Ala 
145                 150                 155                 160 


Ala His Pro Leu Leu His Leu Arg Ser Glu His Gly Ala Gln Gln His 
                165                 170                 175     


Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser Val His Gly Gly Thr 
            180                 185                 190         


Tyr Arg Cys Phe Ser Ser His Gly Phe Ser His Tyr Leu Leu Ser His 
        195                 200                 205             


Pro Ser Asp Pro Leu Glu Leu Ile Val Ser Gly Ser Leu Glu Asp Pro 
    210                 215                 220                 


Arg Pro Ser Pro Thr Arg Ser Val Ser Thr Ala Ala Gly Pro Glu Asp 
225                 230                 235                 240 


Gln Pro Leu Met Pro Thr Gly Ser Val Pro His Ser Gly Leu Arg Arg 
                245                 250                 255     


His Trp Glu Val Leu Ile Gly Val Leu Val Val Ser Ile Leu Leu Leu 
            260                 265                 270         


Ser Leu Leu Leu Phe Leu Leu Leu Gln His Trp Arg Gln Gly Lys His 
        275                 280                 285             


Arg Thr Leu Ala Gln Arg Gln Ala Asp Phe Gln Arg Pro Pro Gly Ala 
    290                 295                 300                 


Ala Glu Pro Glu Pro Lys Asp Gly Gly Leu Gln Arg Arg Ser Ser Pro 
305                 310                 315                 320 


Ala Ala Asp Val Gln Gly Glu Asn Phe Ser Gly Ala Ala Val Lys Asn 
                325                 330                 335     


Thr Gln Pro Glu Asp Gly Val Glu Met Asp Thr Arg Gln Ser Pro His 
            340                 345                 350         


Asp Glu Asp Pro Gln Ala Val Thr Tyr Ala Lys Val Lys His Ser Arg 
        355                 360                 365             


Pro Arg Arg Glu Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe 
    370                 375                 380                 


Leu Asp Thr Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp Thr 
385                 390                 395                 400 


Glu Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu 
                405                 410                 415     


His Ser Phe Thr Leu Arg Gln Lys Ala Thr Glu Pro Pro Pro Ser Gln 
            420                 425                 430         


Glu Gly Ala Ser Pro Ala Glu Pro Ser Val Tyr Ala Thr Leu Ala Ile 
        435                 440                 445             


His 
    


<210>  37
<211>  1344
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1344)

<400>  37
atg atc ccc acc ttc acg gct ctg ctc tgc ctc ggg ctg agt ctg ggc         48
Met Ile Pro Thr Phe Thr Ala Leu Leu Cys Leu Gly Leu Ser Leu Gly           
1               5                   10                  15                

ccc agg acc cac atg cag gca ggg ccc ctc ccc aaa ccc acc ctc tgg         96
Pro Arg Thr His Met Gln Ala Gly Pro Leu Pro Lys Pro Thr Leu Trp           
            20                  25                  30                    

gct gag cca ggc tct gtg atc agc tgg ggg aac tct gtg acc atc tgg        144
Ala Glu Pro Gly Ser Val Ile Ser Trp Gly Asn Ser Val Thr Ile Trp           
        35                  40                  45                        

tgt cag ggg acc ctg gag gct cgg gag tac cgt ctg gat aaa gag gaa        192
Cys Gln Gly Thr Leu Glu Ala Arg Glu Tyr Arg Leu Asp Lys Glu Glu           
    50                  55                  60                            

agc cca gca ccc tgg gac aga cag aac cca ctg gag ccc aag aac aag        240
Ser Pro Ala Pro Trp Asp Arg Gln Asn Pro Leu Glu Pro Lys Asn Lys           
65                  70                  75                  80            

gcc aga ttc tcc atc cca tcc atg aca gag gac tat gca ggg aga tac        288
Ala Arg Phe Ser Ile Pro Ser Met Thr Glu Asp Tyr Ala Gly Arg Tyr           
                85                  90                  95                

cgc tgt tac tat cgc agc cct gta ggc tgg tca cag ccc agt gac ccc        336
Arg Cys Tyr Tyr Arg Ser Pro Val Gly Trp Ser Gln Pro Ser Asp Pro           
            100                 105                 110                   

ctg gag ctg gtg atg aca gga gcc tac agt aaa ccc acc ctt tca gcc        384
Leu Glu Leu Val Met Thr Gly Ala Tyr Ser Lys Pro Thr Leu Ser Ala           
        115                 120                 125                       

ctg ccg agt cct ctt gtg acc tca gga aag agc gtg acc ctg ctg tgt        432
Leu Pro Ser Pro Leu Val Thr Ser Gly Lys Ser Val Thr Leu Leu Cys           
    130                 135                 140                           

cag tca cgg agc cca atg gac act ttc ctt ctg atc aag gag cgg gca        480
Gln Ser Arg Ser Pro Met Asp Thr Phe Leu Leu Ile Lys Glu Arg Ala           
145                 150                 155                 160           

gcc cat ccc cta ctg cat ctg aga tca gag cac gga gct cag cag cac        528
Ala His Pro Leu Leu His Leu Arg Ser Glu His Gly Ala Gln Gln His           
                165                 170                 175               

cag gct gaa ttc ccc atg agt cct gtg acc tca gtg cac ggg ggg acc        576
Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser Val His Gly Gly Thr           
            180                 185                 190                   

tac agg tgc ttc agc tca cac ggc ttc tcc cac tac ctg ctg tca cac        624
Tyr Arg Cys Phe Ser Ser His Gly Phe Ser His Tyr Leu Leu Ser His           
        195                 200                 205                       

ccc agt gac ccc ctg gag ctc ata gtc tca gga tcc ttg gag gat ccc        672
Pro Ser Asp Pro Leu Glu Leu Ile Val Ser Gly Ser Leu Glu Asp Pro           
    210                 215                 220                           

agg ccc tca ccc aca agg tcc gtc tca aca gct gca ggc cct gag gac        720
Arg Pro Ser Pro Thr Arg Ser Val Ser Thr Ala Ala Gly Pro Glu Asp           
225                 230                 235                 240           

cag ccc ctc atg cct aca ggg tca gtc ccc cac agt ggt ctg aga agg        768
Gln Pro Leu Met Pro Thr Gly Ser Val Pro His Ser Gly Leu Arg Arg           
                245                 250                 255               

cac tgg gag gta ctg atc ggg gtc ttg gtg gtc tcc atc ctg ctt ctc        816
His Trp Glu Val Leu Ile Gly Val Leu Val Val Ser Ile Leu Leu Leu           
            260                 265                 270                   

tcc ctc ctc ctc ttc ctc ctc ctc caa cac tgg cgt cag gga aaa cac        864
Ser Leu Leu Leu Phe Leu Leu Leu Gln His Trp Arg Gln Gly Lys His           
        275                 280                 285                       

agg aca ttg gcc cag aga cag gct gat ttc caa cgt cct cca ggg gct        912
Arg Thr Leu Ala Gln Arg Gln Ala Asp Phe Gln Arg Pro Pro Gly Ala           
    290                 295                 300                           

gcc gag cca gag ccc aag gac ggg ggc cta cag agg agg tcc agc cca        960
Ala Glu Pro Glu Pro Lys Asp Gly Gly Leu Gln Arg Arg Ser Ser Pro           
305                 310                 315                 320           

gct gct gac gtc cag gga gaa aac ttc tgt gct gcc gtg aag aac aca       1008
Ala Ala Asp Val Gln Gly Glu Asn Phe Cys Ala Ala Val Lys Asn Thr           
                325                 330                 335               

cag cct gag gac ggg gtg gaa atg gac act cgg agc cca cac gat gaa       1056
Gln Pro Glu Asp Gly Val Glu Met Asp Thr Arg Ser Pro His Asp Glu           
            340                 345                 350                   

gac ccc cag gca gtg acg tat gcc aag gtg aaa cac tcc aga cct agg       1104
Asp Pro Gln Ala Val Thr Tyr Ala Lys Val Lys His Ser Arg Pro Arg           
        355                 360                 365                       

aga gaa atg gcc tct cct ccc tcc cca ctg tct ggg gaa ttc ctg gac       1152
Arg Glu Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp           
    370                 375                 380                           

aca aag gac aga cag gca gaa gag gac aga cag atg gac act gag gct       1200
Thr Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala           
385                 390                 395                 400           

gct gca tct gaa gcc ccc cag gat gtg acc tac gcc cag ctg cac agc       1248
Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser           
                405                 410                 415               

ttt acc ctc aga cag aag gca act gag cct cct cca tcc cag gaa ggg       1296
Phe Thr Leu Arg Gln Lys Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly           
            420                 425                 430                   

gcc tct cca gct gag ccc agt gtc tat gcc act ctg gcc atc cac taa       1344
Ala Ser Pro Ala Glu Pro Ser Val Tyr Ala Thr Leu Ala Ile His               
        435                 440                 445                       


<210>  38
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ile Pro Thr Phe Thr Ala Leu Leu Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Met Gln Ala Gly Pro Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ser Trp Gly Asn Ser Val Thr Ile Trp 
        35                  40                  45              


Cys Gln Gly Thr Leu Glu Ala Arg Glu Tyr Arg Leu Asp Lys Glu Glu 
    50                  55                  60                  


Ser Pro Ala Pro Trp Asp Arg Gln Asn Pro Leu Glu Pro Lys Asn Lys 
65                  70                  75                  80  


Ala Arg Phe Ser Ile Pro Ser Met Thr Glu Asp Tyr Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys Tyr Tyr Arg Ser Pro Val Gly Trp Ser Gln Pro Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Val Met Thr Gly Ala Tyr Ser Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Leu Pro Ser Pro Leu Val Thr Ser Gly Lys Ser Val Thr Leu Leu Cys 
    130                 135                 140                 


Gln Ser Arg Ser Pro Met Asp Thr Phe Leu Leu Ile Lys Glu Arg Ala 
145                 150                 155                 160 


Ala His Pro Leu Leu His Leu Arg Ser Glu His Gly Ala Gln Gln His 
                165                 170                 175     


Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser Val His Gly Gly Thr 
            180                 185                 190         


Tyr Arg Cys Phe Ser Ser His Gly Phe Ser His Tyr Leu Leu Ser His 
        195                 200                 205             


Pro Ser Asp Pro Leu Glu Leu Ile Val Ser Gly Ser Leu Glu Asp Pro 
    210                 215                 220                 


Arg Pro Ser Pro Thr Arg Ser Val Ser Thr Ala Ala Gly Pro Glu Asp 
225                 230                 235                 240 


Gln Pro Leu Met Pro Thr Gly Ser Val Pro His Ser Gly Leu Arg Arg 
                245                 250                 255     


His Trp Glu Val Leu Ile Gly Val Leu Val Val Ser Ile Leu Leu Leu 
            260                 265                 270         


Ser Leu Leu Leu Phe Leu Leu Leu Gln His Trp Arg Gln Gly Lys His 
        275                 280                 285             


Arg Thr Leu Ala Gln Arg Gln Ala Asp Phe Gln Arg Pro Pro Gly Ala 
    290                 295                 300                 


Ala Glu Pro Glu Pro Lys Asp Gly Gly Leu Gln Arg Arg Ser Ser Pro 
305                 310                 315                 320 


Ala Ala Asp Val Gln Gly Glu Asn Phe Cys Ala Ala Val Lys Asn Thr 
                325                 330                 335     


Gln Pro Glu Asp Gly Val Glu Met Asp Thr Arg Ser Pro His Asp Glu 
            340                 345                 350         


Asp Pro Gln Ala Val Thr Tyr Ala Lys Val Lys His Ser Arg Pro Arg 
        355                 360                 365             


Arg Glu Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp 
    370                 375                 380                 


Thr Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala 
385                 390                 395                 400 


Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser 
                405                 410                 415     


Phe Thr Leu Arg Gln Lys Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly 
            420                 425                 430         


Ala Ser Pro Ala Glu Pro Ser Val Tyr Ala Thr Leu Ala Ile His 
        435                 440                 445         


<210>  39
<211>  2640
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(2640)

<400>  39
atg ggg cgc ctg gcc tcg agg ccg ctg ctg ctg gcg ctc ctg tcg ttg         48
Met Gly Arg Leu Ala Ser Arg Pro Leu Leu Leu Ala Leu Leu Ser Leu           
1               5                   10                  15                

gct ctt tgc cga ggg cgt gtg gtg aga gtc ccc aca gcg acc ctg gtt         96
Ala Leu Cys Arg Gly Arg Val Val Arg Val Pro Thr Ala Thr Leu Val           
            20                  25                  30                    

cga gtg gtg ggc act gag ctg gtc atc ccc tgc aac gtc agt gac tat        144
Arg Val Val Gly Thr Glu Leu Val Ile Pro Cys Asn Val Ser Asp Tyr           
        35                  40                  45                        

gat ggc ccc agc gag caa aac ttt gac tgg agc ttc tca tct ttg ggg        192
Asp Gly Pro Ser Glu Gln Asn Phe Asp Trp Ser Phe Ser Ser Leu Gly           
    50                  55                  60                            

agc agc ttt gtg gag ctt gca agc acc tgg gag gtg ggg ttc cca gcc        240
Ser Ser Phe Val Glu Leu Ala Ser Thr Trp Glu Val Gly Phe Pro Ala           
65                  70                  75                  80            

cag ctg tac cag gag cgg ctg cag agg ggc gag atc ctg tta agg cgg        288
Gln Leu Tyr Gln Glu Arg Leu Gln Arg Gly Glu Ile Leu Leu Arg Arg           
                85                  90                  95                

act gcc aac gac gcc gtg gag ctc cac ata aag aac gtc cag cct tca        336
Thr Ala Asn Asp Ala Val Glu Leu His Ile Lys Asn Val Gln Pro Ser           
            100                 105                 110                   

gac caa ggc cac tac aaa tgt tca acc ccc agc aca gat gcc act gtc        384
Asp Gln Gly His Tyr Lys Cys Ser Thr Pro Ser Thr Asp Ala Thr Val           
        115                 120                 125                       

cag gga aac tat gag gac aca gtg cag gtt aaa gtg ctg gcc gac tcc        432
Gln Gly Asn Tyr Glu Asp Thr Val Gln Val Lys Val Leu Ala Asp Ser           
    130                 135                 140                           

ctg cac gtg ggc ccc agc gcg cgg ccc ccg ccg agc ctg agc ctg cgg        480
Leu His Val Gly Pro Ser Ala Arg Pro Pro Pro Ser Leu Ser Leu Arg           
145                 150                 155                 160           

gag ggg gag ccc ttc gag ctg cgc tgc acc gcc gcc tcc gcc tcg ccg        528
Glu Gly Glu Pro Phe Glu Leu Arg Cys Thr Ala Ala Ser Ala Ser Pro           
                165                 170                 175               

ctg cac acg cac ctg gcg ctg ctg tgg gag gtg cac cgc ggc ccg gcc        576
Leu His Thr His Leu Ala Leu Leu Trp Glu Val His Arg Gly Pro Ala           
            180                 185                 190                   

agg cgg agc gtc ctc gcc ctg acc cac gag ggc agg ttc cac ccg ggc        624
Arg Arg Ser Val Leu Ala Leu Thr His Glu Gly Arg Phe His Pro Gly           
        195                 200                 205                       

ctg ggg tac gag cag cgc tac cac agt ggg gac gtg cgc ctc gac acc        672
Leu Gly Tyr Glu Gln Arg Tyr His Ser Gly Asp Val Arg Leu Asp Thr           
    210                 215                 220                           

gtg ggc agc gac gcc tac cgc ctc tca gtg tcc cgg gct ctg tct gcc        720
Val Gly Ser Asp Ala Tyr Arg Leu Ser Val Ser Arg Ala Leu Ser Ala           
225                 230                 235                 240           

gac cag ggc tcc tac agg tgt atc gtc agc gag tgg atc gcc gag cag        768
Asp Gln Gly Ser Tyr Arg Cys Ile Val Ser Glu Trp Ile Ala Glu Gln           
                245                 250                 255               

ggc aac tgg cag gaa atc caa gaa aag gcc gtg gaa gtt gcc acc gtg        816
Gly Asn Trp Gln Glu Ile Gln Glu Lys Ala Val Glu Val Ala Thr Val           
            260                 265                 270                   

gtg atc cag cca tca gtt ctg cga gca gct gtg ccc aag aat gtg tct        864
Val Ile Gln Pro Ser Val Leu Arg Ala Ala Val Pro Lys Asn Val Ser           
        275                 280                 285                       

gtg gct gaa gga aag gaa ctg gac ctg acc tgt aac atc aca aca gac        912
Val Ala Glu Gly Lys Glu Leu Asp Leu Thr Cys Asn Ile Thr Thr Asp           
    290                 295                 300                           

cga gcc gat gac gtc cgg ccc gag gtg acg tgg tcc ttc agc agg atg        960
Arg Ala Asp Asp Val Arg Pro Glu Val Thr Trp Ser Phe Ser Arg Met           
305                 310                 315                 320           

cct gac agc acc cta cct ggc tcc cgc gtg ttg gcg cgg ctt gac cgt       1008
Pro Asp Ser Thr Leu Pro Gly Ser Arg Val Leu Ala Arg Leu Asp Arg           
                325                 330                 335               

gat tcc ctg gtg cac agc tcg cct cat gtt gct ttg agt cat gtg gat       1056
Asp Ser Leu Val His Ser Ser Pro His Val Ala Leu Ser His Val Asp           
            340                 345                 350                   

gca cgc tcc tac cat tta ctg gtt cgg gat gtt agc aaa gaa aac tct       1104
Ala Arg Ser Tyr His Leu Leu Val Arg Asp Val Ser Lys Glu Asn Ser           
        355                 360                 365                       

ggc tac tat tac tgc cac gtg tcc ctg tgg gca ccc gga cac aac agg       1152
Gly Tyr Tyr Tyr Cys His Val Ser Leu Trp Ala Pro Gly His Asn Arg           
    370                 375                 380                           

agc tgg cac aaa gtg gca gag gcc gtg tct tcc cca gct ggt gtg ggt       1200
Ser Trp His Lys Val Ala Glu Ala Val Ser Ser Pro Ala Gly Val Gly           
385                 390                 395                 400           

gtg acc tgg cta gaa cca gac tac cag gtg tac ctg aat gct tcc aag       1248
Val Thr Trp Leu Glu Pro Asp Tyr Gln Val Tyr Leu Asn Ala Ser Lys           
                405                 410                 415               

gtc ccc ggg ttt gcg gat gac ccc aca gag ctg gca tgc cgg gtg gtg       1296
Val Pro Gly Phe Ala Asp Asp Pro Thr Glu Leu Ala Cys Arg Val Val           
            420                 425                 430                   

gac acg aag agt ggg gag gcg aat gtc cga ttc acg gtt tcg tgg tac       1344
Asp Thr Lys Ser Gly Glu Ala Asn Val Arg Phe Thr Val Ser Trp Tyr           
        435                 440                 445                       

tac agg atg aac cgg cgc agc gac aat gtg gtg acc agc gag ctg ctt       1392
Tyr Arg Met Asn Arg Arg Ser Asp Asn Val Val Thr Ser Glu Leu Leu           
    450                 455                 460                           

gca gtc atg gac ggg gac tgg acg cta aaa tat gga gag agg agc aag       1440
Ala Val Met Asp Gly Asp Trp Thr Leu Lys Tyr Gly Glu Arg Ser Lys           
465                 470                 475                 480           

cag cgg gcc cag gat gga gac ttt att ttt tct aag gaa cat aca gac       1488
Gln Arg Ala Gln Asp Gly Asp Phe Ile Phe Ser Lys Glu His Thr Asp           
                485                 490                 495               

acg ttc aat ttc cgg atc caa agg act aca gag gaa gac aga ggc aat       1536
Thr Phe Asn Phe Arg Ile Gln Arg Thr Thr Glu Glu Asp Arg Gly Asn           
            500                 505                 510                   

tat tac tgt gtt gtg tct gcc tgg acc aaa cag cgg aac aac agc tgg       1584
Tyr Tyr Cys Val Val Ser Ala Trp Thr Lys Gln Arg Asn Asn Ser Trp           
        515                 520                 525                       

gtg aaa agc aag gat gtc ttc tcc aag cct gtt aac ata ttt tgg gca       1632
Val Lys Ser Lys Asp Val Phe Ser Lys Pro Val Asn Ile Phe Trp Ala           
    530                 535                 540                           

tta gaa gat tcc gtg ctt gtg gtg aag gcg agg cag cca aag cct ttc       1680
Leu Glu Asp Ser Val Leu Val Val Lys Ala Arg Gln Pro Lys Pro Phe           
545                 550                 555                 560           

ttt gct gcc gga aat aca ttt gag atg act tgc aaa gta tct tcc aag       1728
Phe Ala Ala Gly Asn Thr Phe Glu Met Thr Cys Lys Val Ser Ser Lys           
                565                 570                 575               

aat att aag tcg cca cgc tac tct gtt ctc atc atg gct gag aag cct       1776
Asn Ile Lys Ser Pro Arg Tyr Ser Val Leu Ile Met Ala Glu Lys Pro           
            580                 585                 590                   

gtc ggc gac ctc tcc agt ccc aat gaa acg aag tac atc atc tct ctg       1824
Val Gly Asp Leu Ser Ser Pro Asn Glu Thr Lys Tyr Ile Ile Ser Leu           
        595                 600                 605                       

gac cag gat tct gtg gtg aag ctg gag aat tgg aca gat gca tca cgg       1872
Asp Gln Asp Ser Val Val Lys Leu Glu Asn Trp Thr Asp Ala Ser Arg           
    610                 615                 620                           

gtg gat ggc gtt gtt tta gaa aaa gtg cag gag gat gag ttc cgc tat       1920
Val Asp Gly Val Val Leu Glu Lys Val Gln Glu Asp Glu Phe Arg Tyr           
625                 630                 635                 640           

cga atg tac cag act cag gtc tca gac gca ggg ctg tac cgc tgc atg       1968
Arg Met Tyr Gln Thr Gln Val Ser Asp Ala Gly Leu Tyr Arg Cys Met           
                645                 650                 655               

gtg aca gcc tgg tct cct gtc agg ggc agc ctt tgg cga gaa gca gca       2016
Val Thr Ala Trp Ser Pro Val Arg Gly Ser Leu Trp Arg Glu Ala Ala           
            660                 665                 670                   

acc agt ctc tcc aat cct att gag ata gac ttc caa acc tca ggt cct       2064
Thr Ser Leu Ser Asn Pro Ile Glu Ile Asp Phe Gln Thr Ser Gly Pro           
        675                 680                 685                       

ata ttt aat gct tct gtg cat tca gac aca cca tca gta att cgg gga       2112
Ile Phe Asn Ala Ser Val His Ser Asp Thr Pro Ser Val Ile Arg Gly           
    690                 695                 700                           

gat ctg atc aaa ttg ttc tgt atc atc act gtc gag gga gca gca ctg       2160
Asp Leu Ile Lys Leu Phe Cys Ile Ile Thr Val Glu Gly Ala Ala Leu           
705                 710                 715                 720           

gat cca gat gac atg gcc ttt gat gtg tcc tgg ttt gcg gtg cac tct       2208
Asp Pro Asp Asp Met Ala Phe Asp Val Ser Trp Phe Ala Val His Ser           
                725                 730                 735               

ttt ggc ctg gac aag gct cct gtg ctc ctg tct tcc ctg gat cgg aag       2256
Phe Gly Leu Asp Lys Ala Pro Val Leu Leu Ser Ser Leu Asp Arg Lys           
            740                 745                 750                   

ggc atc gtg acc acc tcc cgg agg gac tgg aag agc gac ctc agc ctg       2304
Gly Ile Val Thr Thr Ser Arg Arg Asp Trp Lys Ser Asp Leu Ser Leu           
        755                 760                 765                       

gag cgc gtg agt gtg ctg gaa ttc ttg ctg caa gtg cat ggc tcc gag       2352
Glu Arg Val Ser Val Leu Glu Phe Leu Leu Gln Val His Gly Ser Glu           
    770                 775                 780                           

gac cag gac ttt ggc aac tac tac tgt tcc gtg act cca tgg gtg aag       2400
Asp Gln Asp Phe Gly Asn Tyr Tyr Cys Ser Val Thr Pro Trp Val Lys           
785                 790                 795                 800           

tca cca aca ggt tcc tgg cag aag gag gca gag atc cac tcc aag ccc       2448
Ser Pro Thr Gly Ser Trp Gln Lys Glu Ala Glu Ile His Ser Lys Pro           
                805                 810                 815               

gtt ttt ata act gtg aag atg gat gtg ctg aac gcc ttc aag tat ccc       2496
Val Phe Ile Thr Val Lys Met Asp Val Leu Asn Ala Phe Lys Tyr Pro           
            820                 825                 830                   

ttg ctg atc ggc gtc ggt ctg tcc acg gtc atc ggg ctc ctg tcc tgt       2544
Leu Leu Ile Gly Val Gly Leu Ser Thr Val Ile Gly Leu Leu Ser Cys           
        835                 840                 845                       

ctc atc ggg tac tgc agc tcc cac tgg tgt tgt aag aag gag gtt cag       2592
Leu Ile Gly Tyr Cys Ser Ser His Trp Cys Cys Lys Lys Glu Val Gln           
    850                 855                 860                           

gag aca cgg cgc gag cgc cgc agg ctc atg tcg atg gag atg gac tag       2640
Glu Thr Arg Arg Glu Arg Arg Arg Leu Met Ser Met Glu Met Asp               
865                 870                 875                               


<210>  40
<211>  879
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Gly Arg Leu Ala Ser Arg Pro Leu Leu Leu Ala Leu Leu Ser Leu 
1               5                   10                  15      


Ala Leu Cys Arg Gly Arg Val Val Arg Val Pro Thr Ala Thr Leu Val 
            20                  25                  30          


Arg Val Val Gly Thr Glu Leu Val Ile Pro Cys Asn Val Ser Asp Tyr 
        35                  40                  45              


Asp Gly Pro Ser Glu Gln Asn Phe Asp Trp Ser Phe Ser Ser Leu Gly 
    50                  55                  60                  


Ser Ser Phe Val Glu Leu Ala Ser Thr Trp Glu Val Gly Phe Pro Ala 
65                  70                  75                  80  


Gln Leu Tyr Gln Glu Arg Leu Gln Arg Gly Glu Ile Leu Leu Arg Arg 
                85                  90                  95      


Thr Ala Asn Asp Ala Val Glu Leu His Ile Lys Asn Val Gln Pro Ser 
            100                 105                 110         


Asp Gln Gly His Tyr Lys Cys Ser Thr Pro Ser Thr Asp Ala Thr Val 
        115                 120                 125             


Gln Gly Asn Tyr Glu Asp Thr Val Gln Val Lys Val Leu Ala Asp Ser 
    130                 135                 140                 


Leu His Val Gly Pro Ser Ala Arg Pro Pro Pro Ser Leu Ser Leu Arg 
145                 150                 155                 160 


Glu Gly Glu Pro Phe Glu Leu Arg Cys Thr Ala Ala Ser Ala Ser Pro 
                165                 170                 175     


Leu His Thr His Leu Ala Leu Leu Trp Glu Val His Arg Gly Pro Ala 
            180                 185                 190         


Arg Arg Ser Val Leu Ala Leu Thr His Glu Gly Arg Phe His Pro Gly 
        195                 200                 205             


Leu Gly Tyr Glu Gln Arg Tyr His Ser Gly Asp Val Arg Leu Asp Thr 
    210                 215                 220                 


Val Gly Ser Asp Ala Tyr Arg Leu Ser Val Ser Arg Ala Leu Ser Ala 
225                 230                 235                 240 


Asp Gln Gly Ser Tyr Arg Cys Ile Val Ser Glu Trp Ile Ala Glu Gln 
                245                 250                 255     


Gly Asn Trp Gln Glu Ile Gln Glu Lys Ala Val Glu Val Ala Thr Val 
            260                 265                 270         


Val Ile Gln Pro Ser Val Leu Arg Ala Ala Val Pro Lys Asn Val Ser 
        275                 280                 285             


Val Ala Glu Gly Lys Glu Leu Asp Leu Thr Cys Asn Ile Thr Thr Asp 
    290                 295                 300                 


Arg Ala Asp Asp Val Arg Pro Glu Val Thr Trp Ser Phe Ser Arg Met 
305                 310                 315                 320 


Pro Asp Ser Thr Leu Pro Gly Ser Arg Val Leu Ala Arg Leu Asp Arg 
                325                 330                 335     


Asp Ser Leu Val His Ser Ser Pro His Val Ala Leu Ser His Val Asp 
            340                 345                 350         


Ala Arg Ser Tyr His Leu Leu Val Arg Asp Val Ser Lys Glu Asn Ser 
        355                 360                 365             


Gly Tyr Tyr Tyr Cys His Val Ser Leu Trp Ala Pro Gly His Asn Arg 
    370                 375                 380                 


Ser Trp His Lys Val Ala Glu Ala Val Ser Ser Pro Ala Gly Val Gly 
385                 390                 395                 400 


Val Thr Trp Leu Glu Pro Asp Tyr Gln Val Tyr Leu Asn Ala Ser Lys 
                405                 410                 415     


Val Pro Gly Phe Ala Asp Asp Pro Thr Glu Leu Ala Cys Arg Val Val 
            420                 425                 430         


Asp Thr Lys Ser Gly Glu Ala Asn Val Arg Phe Thr Val Ser Trp Tyr 
        435                 440                 445             


Tyr Arg Met Asn Arg Arg Ser Asp Asn Val Val Thr Ser Glu Leu Leu 
    450                 455                 460                 


Ala Val Met Asp Gly Asp Trp Thr Leu Lys Tyr Gly Glu Arg Ser Lys 
465                 470                 475                 480 


Gln Arg Ala Gln Asp Gly Asp Phe Ile Phe Ser Lys Glu His Thr Asp 
                485                 490                 495     


Thr Phe Asn Phe Arg Ile Gln Arg Thr Thr Glu Glu Asp Arg Gly Asn 
            500                 505                 510         


Tyr Tyr Cys Val Val Ser Ala Trp Thr Lys Gln Arg Asn Asn Ser Trp 
        515                 520                 525             


Val Lys Ser Lys Asp Val Phe Ser Lys Pro Val Asn Ile Phe Trp Ala 
    530                 535                 540                 


Leu Glu Asp Ser Val Leu Val Val Lys Ala Arg Gln Pro Lys Pro Phe 
545                 550                 555                 560 


Phe Ala Ala Gly Asn Thr Phe Glu Met Thr Cys Lys Val Ser Ser Lys 
                565                 570                 575     


Asn Ile Lys Ser Pro Arg Tyr Ser Val Leu Ile Met Ala Glu Lys Pro 
            580                 585                 590         


Val Gly Asp Leu Ser Ser Pro Asn Glu Thr Lys Tyr Ile Ile Ser Leu 
        595                 600                 605             


Asp Gln Asp Ser Val Val Lys Leu Glu Asn Trp Thr Asp Ala Ser Arg 
    610                 615                 620                 


Val Asp Gly Val Val Leu Glu Lys Val Gln Glu Asp Glu Phe Arg Tyr 
625                 630                 635                 640 


Arg Met Tyr Gln Thr Gln Val Ser Asp Ala Gly Leu Tyr Arg Cys Met 
                645                 650                 655     


Val Thr Ala Trp Ser Pro Val Arg Gly Ser Leu Trp Arg Glu Ala Ala 
            660                 665                 670         


Thr Ser Leu Ser Asn Pro Ile Glu Ile Asp Phe Gln Thr Ser Gly Pro 
        675                 680                 685             


Ile Phe Asn Ala Ser Val His Ser Asp Thr Pro Ser Val Ile Arg Gly 
    690                 695                 700                 


Asp Leu Ile Lys Leu Phe Cys Ile Ile Thr Val Glu Gly Ala Ala Leu 
705                 710                 715                 720 


Asp Pro Asp Asp Met Ala Phe Asp Val Ser Trp Phe Ala Val His Ser 
                725                 730                 735     


Phe Gly Leu Asp Lys Ala Pro Val Leu Leu Ser Ser Leu Asp Arg Lys 
            740                 745                 750         


Gly Ile Val Thr Thr Ser Arg Arg Asp Trp Lys Ser Asp Leu Ser Leu 
        755                 760                 765             


Glu Arg Val Ser Val Leu Glu Phe Leu Leu Gln Val His Gly Ser Glu 
    770                 775                 780                 


Asp Gln Asp Phe Gly Asn Tyr Tyr Cys Ser Val Thr Pro Trp Val Lys 
785                 790                 795                 800 


Ser Pro Thr Gly Ser Trp Gln Lys Glu Ala Glu Ile His Ser Lys Pro 
                805                 810                 815     


Val Phe Ile Thr Val Lys Met Asp Val Leu Asn Ala Phe Lys Tyr Pro 
            820                 825                 830         


Leu Leu Ile Gly Val Gly Leu Ser Thr Val Ile Gly Leu Leu Ser Cys 
        835                 840                 845             


Leu Ile Gly Tyr Cys Ser Ser His Trp Cys Cys Lys Lys Glu Val Gln 
    850                 855                 860                 


Glu Thr Arg Arg Glu Arg Arg Arg Leu Met Ser Met Glu Met Asp 
865                 870                 875                 


<210>  41
<211>  1287
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1287)

<400>  41
atg gca gtg ggg gcc agt ggt cta gaa gga gat aag atg gct ggt gcc         48
Met Ala Val Gly Ala Ser Gly Leu Glu Gly Asp Lys Met Ala Gly Ala           
1               5                   10                  15                

atg cct ctg caa ctc ctc ctg ttg ctg atc cta ctg ggc cct ggc aac         96
Met Pro Leu Gln Leu Leu Leu Leu Leu Ile Leu Leu Gly Pro Gly Asn           
            20                  25                  30                    

agc ttg cag ctg tgg gac acc tgg gca gat gaa gcc gag aaa gcc ttg        144
Ser Leu Gln Leu Trp Asp Thr Trp Ala Asp Glu Ala Glu Lys Ala Leu           
        35                  40                  45                        

ggt ccc ctg ctt gcc cgg gac cgg aga cag gcc acc gaa tat gag tac        192
Gly Pro Leu Leu Ala Arg Asp Arg Arg Gln Ala Thr Glu Tyr Glu Tyr           
    50                  55                  60                            

cta gat tat gat ttc ctg cca gaa acg gag cct cca gaa atg ctg agg        240
Leu Asp Tyr Asp Phe Leu Pro Glu Thr Glu Pro Pro Glu Met Leu Arg           
65                  70                  75                  80            

aac agc act gac acc act cct ctg act ggg cct gga acc cct gag tct        288
Asn Ser Thr Asp Thr Thr Pro Leu Thr Gly Pro Gly Thr Pro Glu Ser           
                85                  90                  95                

acc act gtg gag cct gct gca agg cgt tct act ggc ctg gat gca gga        336
Thr Thr Val Glu Pro Ala Ala Arg Arg Ser Thr Gly Leu Asp Ala Gly           
            100                 105                 110                   

ggg gca gtc aca gag ctg acc acg gag ctg gcc aac atg ggg aac ctg        384
Gly Ala Val Thr Glu Leu Thr Thr Glu Leu Ala Asn Met Gly Asn Leu           
        115                 120                 125                       

tcc acg gat tca gca gct atg gag ata cag acc act caa cca gca gcc        432
Ser Thr Asp Ser Ala Ala Met Glu Ile Gln Thr Thr Gln Pro Ala Ala           
    130                 135                 140                           

acg gag gca cag acc act caa cca gtg ccc acg gag gca cag acc act        480
Thr Glu Ala Gln Thr Thr Gln Pro Val Pro Thr Glu Ala Gln Thr Thr           
145                 150                 155                 160           

cca ctg gca gcc aca gag gca cag aca act cga ctg acg gcc acg gag        528
Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr Arg Leu Thr Ala Thr Glu           
                165                 170                 175               

gca cag acc act cca ctg gca gcc aca gag gca cag acc act cca cca        576
Ala Gln Thr Thr Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr Pro Pro           
            180                 185                 190                   

gca gcc acg gaa gca cag acc act caa ccc aca ggc ctg gag gca cag        624
Ala Ala Thr Glu Ala Gln Thr Thr Gln Pro Thr Gly Leu Glu Ala Gln           
        195                 200                 205                       

acc act gca cca gca gcc atg gag gca cag acc act gca cca gca gcc        672
Thr Thr Ala Pro Ala Ala Met Glu Ala Gln Thr Thr Ala Pro Ala Ala           
    210                 215                 220                           

atg gaa gca cag acc act cca cca gca gcc atg gag gca cag acc act        720
Met Glu Ala Gln Thr Thr Pro Pro Ala Ala Met Glu Ala Gln Thr Thr           
225                 230                 235                 240           

caa acc aca gcc atg gag gca cag acc act gca cca gaa gcc acg gag        768
Gln Thr Thr Ala Met Glu Ala Gln Thr Thr Ala Pro Glu Ala Thr Glu           
                245                 250                 255               

gca cag acc act caa ccc aca gcc acg gag gca cag acc act cca ctg        816
Ala Gln Thr Thr Gln Pro Thr Ala Thr Glu Ala Gln Thr Thr Pro Leu           
            260                 265                 270                   

gca gcc atg gag gcc ctg tcc aca gaa ccc agt gcc aca gag gcc ctg        864
Ala Ala Met Glu Ala Leu Ser Thr Glu Pro Ser Ala Thr Glu Ala Leu           
        275                 280                 285                       

tcc atg gaa cct act acc aaa aga ggt ctg ttc ata ccc ttt tct gtg        912
Ser Met Glu Pro Thr Thr Lys Arg Gly Leu Phe Ile Pro Phe Ser Val           
    290                 295                 300                           

tcc tct gtt act cac aag ggc att ccc atg gca gcc agc aat ttg tcc        960
Ser Ser Val Thr His Lys Gly Ile Pro Met Ala Ala Ser Asn Leu Ser           
305                 310                 315                 320           

gtc aac tac cca gtg ggg gcc cca gac cac atc tct gtg aag cag tgc       1008
Val Asn Tyr Pro Val Gly Ala Pro Asp His Ile Ser Val Lys Gln Cys           
                325                 330                 335               

ctg ctg gcc atc cta atc ttg gcg ctg gtg gcc act atc ttc ttc gtg       1056
Leu Leu Ala Ile Leu Ile Leu Ala Leu Val Ala Thr Ile Phe Phe Val           
            340                 345                 350                   

tgc act gtg gtg ctg gcg gtc cgc ctc tcc cgc aag ggc cac atg tac       1104
Cys Thr Val Val Leu Ala Val Arg Leu Ser Arg Lys Gly His Met Tyr           
        355                 360                 365                       

ccc gtg cgt aat tac tcc ccc acc gag atg gtc tgc atc tca tcc ctg       1152
Pro Val Arg Asn Tyr Ser Pro Thr Glu Met Val Cys Ile Ser Ser Leu           
    370                 375                 380                           

ttg cct gat ggg ggt gag ggg ccc tct gcc aca gcc aat ggg ggc ctg       1200
Leu Pro Asp Gly Gly Glu Gly Pro Ser Ala Thr Ala Asn Gly Gly Leu           
385                 390                 395                 400           

tcc aag gcc aag agc ccg ggc ctg acg cca gag ccc agg gag gac cgt       1248
Ser Lys Ala Lys Ser Pro Gly Leu Thr Pro Glu Pro Arg Glu Asp Arg           
                405                 410                 415               

gag ggg gat gac ctc acc ctg cac agc ttc ctc cct tag                   1287
Glu Gly Asp Asp Leu Thr Leu His Ser Phe Leu Pro                           
            420                 425                                       


<210>  42
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ala Val Gly Ala Ser Gly Leu Glu Gly Asp Lys Met Ala Gly Ala 
1               5                   10                  15      


Met Pro Leu Gln Leu Leu Leu Leu Leu Ile Leu Leu Gly Pro Gly Asn 
            20                  25                  30          


Ser Leu Gln Leu Trp Asp Thr Trp Ala Asp Glu Ala Glu Lys Ala Leu 
        35                  40                  45              


Gly Pro Leu Leu Ala Arg Asp Arg Arg Gln Ala Thr Glu Tyr Glu Tyr 
    50                  55                  60                  


Leu Asp Tyr Asp Phe Leu Pro Glu Thr Glu Pro Pro Glu Met Leu Arg 
65                  70                  75                  80  


Asn Ser Thr Asp Thr Thr Pro Leu Thr Gly Pro Gly Thr Pro Glu Ser 
                85                  90                  95      


Thr Thr Val Glu Pro Ala Ala Arg Arg Ser Thr Gly Leu Asp Ala Gly 
            100                 105                 110         


Gly Ala Val Thr Glu Leu Thr Thr Glu Leu Ala Asn Met Gly Asn Leu 
        115                 120                 125             


Ser Thr Asp Ser Ala Ala Met Glu Ile Gln Thr Thr Gln Pro Ala Ala 
    130                 135                 140                 


Thr Glu Ala Gln Thr Thr Gln Pro Val Pro Thr Glu Ala Gln Thr Thr 
145                 150                 155                 160 


Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr Arg Leu Thr Ala Thr Glu 
                165                 170                 175     


Ala Gln Thr Thr Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr Pro Pro 
            180                 185                 190         


Ala Ala Thr Glu Ala Gln Thr Thr Gln Pro Thr Gly Leu Glu Ala Gln 
        195                 200                 205             


Thr Thr Ala Pro Ala Ala Met Glu Ala Gln Thr Thr Ala Pro Ala Ala 
    210                 215                 220                 


Met Glu Ala Gln Thr Thr Pro Pro Ala Ala Met Glu Ala Gln Thr Thr 
225                 230                 235                 240 


Gln Thr Thr Ala Met Glu Ala Gln Thr Thr Ala Pro Glu Ala Thr Glu 
                245                 250                 255     


Ala Gln Thr Thr Gln Pro Thr Ala Thr Glu Ala Gln Thr Thr Pro Leu 
            260                 265                 270         


Ala Ala Met Glu Ala Leu Ser Thr Glu Pro Ser Ala Thr Glu Ala Leu 
        275                 280                 285             


Ser Met Glu Pro Thr Thr Lys Arg Gly Leu Phe Ile Pro Phe Ser Val 
    290                 295                 300                 


Ser Ser Val Thr His Lys Gly Ile Pro Met Ala Ala Ser Asn Leu Ser 
305                 310                 315                 320 


Val Asn Tyr Pro Val Gly Ala Pro Asp His Ile Ser Val Lys Gln Cys 
                325                 330                 335     


Leu Leu Ala Ile Leu Ile Leu Ala Leu Val Ala Thr Ile Phe Phe Val 
            340                 345                 350         


Cys Thr Val Val Leu Ala Val Arg Leu Ser Arg Lys Gly His Met Tyr 
        355                 360                 365             


Pro Val Arg Asn Tyr Ser Pro Thr Glu Met Val Cys Ile Ser Ser Leu 
    370                 375                 380                 


Leu Pro Asp Gly Gly Glu Gly Pro Ser Ala Thr Ala Asn Gly Gly Leu 
385                 390                 395                 400 


Ser Lys Ala Lys Ser Pro Gly Leu Thr Pro Glu Pro Arg Glu Asp Arg 
                405                 410                 415     


Glu Gly Asp Asp Leu Thr Leu His Ser Phe Leu Pro 
            420                 425             


<210>  43
<211>  1239
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1239)

<400>  43
atg cct ctg caa ctc ctc ctg ttg ctg atc cta ctg ggc cct ggc aac         48
Met Pro Leu Gln Leu Leu Leu Leu Leu Ile Leu Leu Gly Pro Gly Asn           
1               5                   10                  15                

agc ttg cag ctg tgg gac acc tgg gca gat gaa gcc gag aaa gcc ttg         96
Ser Leu Gln Leu Trp Asp Thr Trp Ala Asp Glu Ala Glu Lys Ala Leu           
            20                  25                  30                    

ggt ccc ctg ctt gcc cgg gac cgg aga cag gcc acc gaa tat gag tac        144
Gly Pro Leu Leu Ala Arg Asp Arg Arg Gln Ala Thr Glu Tyr Glu Tyr           
        35                  40                  45                        

cta gat tat gat ttc ctg cca gaa acg gag cct cca gaa atg ctg agg        192
Leu Asp Tyr Asp Phe Leu Pro Glu Thr Glu Pro Pro Glu Met Leu Arg           
    50                  55                  60                            

aac agc act gac acc act cct ctg act ggg cct gga acc cct gag tct        240
Asn Ser Thr Asp Thr Thr Pro Leu Thr Gly Pro Gly Thr Pro Glu Ser           
65                  70                  75                  80            

acc act gtg gag cct gct gca agg cgt tct act ggc ctg gat gca gga        288
Thr Thr Val Glu Pro Ala Ala Arg Arg Ser Thr Gly Leu Asp Ala Gly           
                85                  90                  95                

ggg gca gtc aca gag ctg acc acg gag ctg gcc aac atg ggg aac ctg        336
Gly Ala Val Thr Glu Leu Thr Thr Glu Leu Ala Asn Met Gly Asn Leu           
            100                 105                 110                   

tcc acg gat tca gca gct atg gag ata cag acc act caa cca gca gcc        384
Ser Thr Asp Ser Ala Ala Met Glu Ile Gln Thr Thr Gln Pro Ala Ala           
        115                 120                 125                       

acg gag gca cag acc act caa cca gtg ccc acg gag gca cag acc act        432
Thr Glu Ala Gln Thr Thr Gln Pro Val Pro Thr Glu Ala Gln Thr Thr           
    130                 135                 140                           

cca ctg gca gcc aca gag gca cag aca act cga ctg acg gcc acg gag        480
Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr Arg Leu Thr Ala Thr Glu           
145                 150                 155                 160           

gca cag acc act cca ctg gca gcc aca gag gca cag acc act cca cca        528
Ala Gln Thr Thr Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr Pro Pro           
                165                 170                 175               

gca gcc acg gaa gca cag acc act caa ccc aca ggc ctg gag gca cag        576
Ala Ala Thr Glu Ala Gln Thr Thr Gln Pro Thr Gly Leu Glu Ala Gln           
            180                 185                 190                   

acc act gca cca gca gcc atg gag gca cag acc act gca cca gca gcc        624
Thr Thr Ala Pro Ala Ala Met Glu Ala Gln Thr Thr Ala Pro Ala Ala           
        195                 200                 205                       

atg gaa gca cag acc act cca cca gca gcc atg gag gca cag acc act        672
Met Glu Ala Gln Thr Thr Pro Pro Ala Ala Met Glu Ala Gln Thr Thr           
    210                 215                 220                           

caa acc aca gcc atg gag gca cag acc act gca cca gaa gcc acg gag        720
Gln Thr Thr Ala Met Glu Ala Gln Thr Thr Ala Pro Glu Ala Thr Glu           
225                 230                 235                 240           

gca cag acc act caa ccc aca gcc acg gag gca cag acc act cca ctg        768
Ala Gln Thr Thr Gln Pro Thr Ala Thr Glu Ala Gln Thr Thr Pro Leu           
                245                 250                 255               

gca gcc atg gag gcc ctg tcc aca gaa ccc agt gcc aca gag gcc ctg        816
Ala Ala Met Glu Ala Leu Ser Thr Glu Pro Ser Ala Thr Glu Ala Leu           
            260                 265                 270                   

tcc atg gaa cct act acc aaa aga ggt ctg ttc ata ccc ttt tct gtg        864
Ser Met Glu Pro Thr Thr Lys Arg Gly Leu Phe Ile Pro Phe Ser Val           
        275                 280                 285                       

tcc tct gtt act cac aag ggc att ccc atg gca gcc agc aat ttg tcc        912
Ser Ser Val Thr His Lys Gly Ile Pro Met Ala Ala Ser Asn Leu Ser           
    290                 295                 300                           

gtc aac tac cca gtg ggg gcc cca gac cac atc tct gtg aag cag tgc        960
Val Asn Tyr Pro Val Gly Ala Pro Asp His Ile Ser Val Lys Gln Cys           
305                 310                 315                 320           

ctg ctg gcc atc cta atc ttg gcg ctg gtg gcc act atc ttc ttc gtg       1008
Leu Leu Ala Ile Leu Ile Leu Ala Leu Val Ala Thr Ile Phe Phe Val           
                325                 330                 335               

tgc act gtg gtg ctg gcg gtc cgc ctc tcc cgc aag ggc cac atg tac       1056
Cys Thr Val Val Leu Ala Val Arg Leu Ser Arg Lys Gly His Met Tyr           
            340                 345                 350                   

ccc gtg cgt aat tac tcc ccc acc gag atg gtc tgc atc tca tcc ctg       1104
Pro Val Arg Asn Tyr Ser Pro Thr Glu Met Val Cys Ile Ser Ser Leu           
        355                 360                 365                       

ttg cct gat ggg ggt gag ggg ccc tct gcc aca gcc aat ggg ggc ctg       1152
Leu Pro Asp Gly Gly Glu Gly Pro Ser Ala Thr Ala Asn Gly Gly Leu           
    370                 375                 380                           

tcc aag gcc aag agc ccg ggc ctg acg cca gag ccc agg gag gac cgt       1200
Ser Lys Ala Lys Ser Pro Gly Leu Thr Pro Glu Pro Arg Glu Asp Arg           
385                 390                 395                 400           

gag ggg gat gac ctc acc ctg cac agc ttc ctc cct tag                   1239
Glu Gly Asp Asp Leu Thr Leu His Ser Phe Leu Pro                           
                405                 410                                   


<210>  44
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Pro Leu Gln Leu Leu Leu Leu Leu Ile Leu Leu Gly Pro Gly Asn 
1               5                   10                  15      


Ser Leu Gln Leu Trp Asp Thr Trp Ala Asp Glu Ala Glu Lys Ala Leu 
            20                  25                  30          


Gly Pro Leu Leu Ala Arg Asp Arg Arg Gln Ala Thr Glu Tyr Glu Tyr 
        35                  40                  45              


Leu Asp Tyr Asp Phe Leu Pro Glu Thr Glu Pro Pro Glu Met Leu Arg 
    50                  55                  60                  


Asn Ser Thr Asp Thr Thr Pro Leu Thr Gly Pro Gly Thr Pro Glu Ser 
65                  70                  75                  80  


Thr Thr Val Glu Pro Ala Ala Arg Arg Ser Thr Gly Leu Asp Ala Gly 
                85                  90                  95      


Gly Ala Val Thr Glu Leu Thr Thr Glu Leu Ala Asn Met Gly Asn Leu 
            100                 105                 110         


Ser Thr Asp Ser Ala Ala Met Glu Ile Gln Thr Thr Gln Pro Ala Ala 
        115                 120                 125             


Thr Glu Ala Gln Thr Thr Gln Pro Val Pro Thr Glu Ala Gln Thr Thr 
    130                 135                 140                 


Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr Arg Leu Thr Ala Thr Glu 
145                 150                 155                 160 


Ala Gln Thr Thr Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr Pro Pro 
                165                 170                 175     


Ala Ala Thr Glu Ala Gln Thr Thr Gln Pro Thr Gly Leu Glu Ala Gln 
            180                 185                 190         


Thr Thr Ala Pro Ala Ala Met Glu Ala Gln Thr Thr Ala Pro Ala Ala 
        195                 200                 205             


Met Glu Ala Gln Thr Thr Pro Pro Ala Ala Met Glu Ala Gln Thr Thr 
    210                 215                 220                 


Gln Thr Thr Ala Met Glu Ala Gln Thr Thr Ala Pro Glu Ala Thr Glu 
225                 230                 235                 240 


Ala Gln Thr Thr Gln Pro Thr Ala Thr Glu Ala Gln Thr Thr Pro Leu 
                245                 250                 255     


Ala Ala Met Glu Ala Leu Ser Thr Glu Pro Ser Ala Thr Glu Ala Leu 
            260                 265                 270         


Ser Met Glu Pro Thr Thr Lys Arg Gly Leu Phe Ile Pro Phe Ser Val 
        275                 280                 285             


Ser Ser Val Thr His Lys Gly Ile Pro Met Ala Ala Ser Asn Leu Ser 
    290                 295                 300                 


Val Asn Tyr Pro Val Gly Ala Pro Asp His Ile Ser Val Lys Gln Cys 
305                 310                 315                 320 


Leu Leu Ala Ile Leu Ile Leu Ala Leu Val Ala Thr Ile Phe Phe Val 
                325                 330                 335     


Cys Thr Val Val Leu Ala Val Arg Leu Ser Arg Lys Gly His Met Tyr 
            340                 345                 350         


Pro Val Arg Asn Tyr Ser Pro Thr Glu Met Val Cys Ile Ser Ser Leu 
        355                 360                 365             


Leu Pro Asp Gly Gly Glu Gly Pro Ser Ala Thr Ala Asn Gly Gly Leu 
    370                 375                 380                 


Ser Lys Ala Lys Ser Pro Gly Leu Thr Pro Glu Pro Arg Glu Asp Arg 
385                 390                 395                 400 


Glu Gly Asp Asp Leu Thr Leu His Ser Phe Leu Pro 
                405                 410         


<210>  45
<211>  1341
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1341)

<400>  45
atg tgg tgg cgt ctt tgg tgg ttg ttg ctt ctt ctt ctt ctc ctg tgg         48
Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu Leu Trp           
1               5                   10                  15                

ccc atg gtg tgg gcc gac tac aaa gac cat gac gga gat tat aaa gat         96
Pro Met Val Trp Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp           
            20                  25                  30                    

cat gac atc gat tac aag gat gac gat gac aag gga gga ggg tct gga        144
His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Ser Gly           
        35                  40                  45                        

aac tct acc atg ggc tct ggt ggc ggc ggc ggc tcc ggc ggc ggc gga        192
Asn Ser Thr Met Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly           
    50                  55                  60                            

tct ctc gaa ctt aat ttg acc gat tca gag aat gcc aca tgc ctt tat        240
Ser Leu Glu Leu Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr           
65                  70                  75                  80            

gcg aaa tgg cag atg aat ttc act gtt cgg tat gaa acc aca aat aaa        288
Ala Lys Trp Gln Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys           
                85                  90                  95                

act tat aaa acc gtt acc ata agc gac cat gga act gtg acc tat aat        336
Thr Tyr Lys Thr Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn           
            100                 105                 110                   

gga agc ata tgt gga gat gat cag aat ggt ccc aaa att gct gtt cag        384
Gly Ser Ile Cys Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln           
        115                 120                 125                       

ttc gga cct ggt ttc tcc tgg att gct aat ttt act aag gca gcc tct        432
Phe Gly Pro Gly Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser           
    130                 135                 140                           

acc tat tcc ata gac tca gtt tct ttt agt tac aac aca ggg gat aac        480
Thr Tyr Ser Ile Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn           
145                 150                 155                 160           

aca acg ttt cct gat gcc gaa gat aaa ggc ata ctc acc gtt gat gaa        528
Thr Thr Phe Pro Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu           
                165                 170                 175               

ctc ttg gcc atc aga ata cct ctt aat gac ctg ttt aga tgc aat agc        576
Leu Leu Ala Ile Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser           
            180                 185                 190                   

ctc tcc acc ctg gag aag aat gat gtg gta caa cac tac tgg gat gtg        624
Leu Ser Thr Leu Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val           
        195                 200                 205                       

ttg gtt caa gct ttt gta caa aat ggg acc gtc tct aca aat gag ttc        672
Leu Val Gln Ala Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe           
    210                 215                 220                           

ctc tgt gat aaa gac aaa acc agt act gtg gca cca acc ata cac aca        720
Leu Cys Asp Lys Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr           
225                 230                 235                 240           

aca gtg cca tct cca acg acc acc cct aca ccc aag gag aaa cct gaa        768
Thr Val Pro Ser Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu           
                245                 250                 255               

gcc ggt aca tat tca gtg aat aat gga aat gat aca tgc ctt ctg gcc        816
Ala Gly Thr Tyr Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala           
            260                 265                 270                   

acc atg ggc ctt cag ctc aac atc act cag gat aag gtc gct tca gtc        864
Thr Met Gly Leu Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val           
        275                 280                 285                       

att aac att aac ccc aat act act cac tct aca ggc tct tgc agg agt        912
Ile Asn Ile Asn Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser           
    290                 295                 300                           

cac acg gcg ctc ctg cgg ttg aat agc agc acc att aag tat ctt gac        960
His Thr Ala Leu Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp           
305                 310                 315                 320           

ttt gtc ttt gct gtc aag aat gag aac aga ttt tat ctg aaa gag gtc       1008
Phe Val Phe Ala Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val           
                325                 330                 335               

aac atc tct atg tat ttg gtc aat ggg agt gtg ttc tcc att gct aat       1056
Asn Ile Ser Met Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn           
            340                 345                 350                   

aac aat ctc agc tac tgg gat gcc cct ctg ggt tct tcc tat atg tgc       1104
Asn Asn Leu Ser Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys           
        355                 360                 365                       

aac aaa gag cag act gtt tca gtg tcc ggc gca ttt cag att aat act       1152
Asn Lys Glu Gln Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr           
    370                 375                 380                           

ttt gat ctt cgg gtg cag cct ttc aat gtg aca caa gga aag tat tcc       1200
Phe Asp Leu Arg Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser           
385                 390                 395                 400           

acc gcc caa gag tgt tct ttg gat gat gac acc ata ctg atc ccc atc       1248
Thr Ala Gln Glu Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile           
                405                 410                 415               

att gta ggt gcc ggc ctg agc ggc ctt att atc gtt atc gtc att gca       1296
Ile Val Gly Ala Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala           
            420                 425                 430                   

tac gtg att gga cgg cgg aaa tct tat gcc ggt tat cag acg ctt           1341
Tyr Val Ile Gly Arg Arg Lys Ser Tyr Ala Gly Tyr Gln Thr Leu               
        435                 440                 445                       


<210>  46
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu Leu Trp 
1               5                   10                  15      


Pro Met Val Trp Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp 
            20                  25                  30          


His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Ser Gly 
        35                  40                  45              


Asn Ser Thr Met Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Leu Glu Leu Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr 
65                  70                  75                  80  


Ala Lys Trp Gln Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys 
                85                  90                  95      


Thr Tyr Lys Thr Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn 
            100                 105                 110         


Gly Ser Ile Cys Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln 
        115                 120                 125             


Phe Gly Pro Gly Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser 
    130                 135                 140                 


Thr Tyr Ser Ile Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn 
145                 150                 155                 160 


Thr Thr Phe Pro Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu 
                165                 170                 175     


Leu Leu Ala Ile Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser 
            180                 185                 190         


Leu Ser Thr Leu Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val 
        195                 200                 205             


Leu Val Gln Ala Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe 
    210                 215                 220                 


Leu Cys Asp Lys Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr 
225                 230                 235                 240 


Thr Val Pro Ser Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu 
                245                 250                 255     


Ala Gly Thr Tyr Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala 
            260                 265                 270         


Thr Met Gly Leu Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val 
        275                 280                 285             


Ile Asn Ile Asn Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser 
    290                 295                 300                 


His Thr Ala Leu Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp 
305                 310                 315                 320 


Phe Val Phe Ala Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val 
                325                 330                 335     


Asn Ile Ser Met Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn 
            340                 345                 350         


Asn Asn Leu Ser Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys 
        355                 360                 365             


Asn Lys Glu Gln Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr 
    370                 375                 380                 


Phe Asp Leu Arg Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser 
385                 390                 395                 400 


Thr Ala Gln Glu Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile 
                405                 410                 415     


Ile Val Gly Ala Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala 
            420                 425                 430         


Tyr Val Ile Gly Arg Arg Lys Ser Tyr Ala Gly Tyr Gln Thr Leu 
        435                 440                 445         


<210>  47
<211>  3090
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(3090)

<400>  47
atg tgg tgg aga ttg tgg tgg ttg ctc ctt ctc ttg ttg ttg ctt tgg         48
Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu Leu Trp           
1               5                   10                  15                

cca atg gta tgg gcg acc cac cgg ccg ccc atg tgg agc cct gtg tgg         96
Pro Met Val Trp Ala Thr His Arg Pro Pro Met Trp Ser Pro Val Trp           
            20                  25                  30                    

ccc ggc ggt ggg tcc gac tac aaa gac cat gac gga gat tat aaa gat        144
Pro Gly Gly Gly Ser Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp           
        35                  40                  45                        

cat gac atc gat tac aag gat gac gat gac aag gga aac agt acc atg        192
His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Asn Ser Thr Met           
    50                  55                  60                            

ggc tca ggc ggt gga gga ggc tcc gga gga ggt ggc agc gca cgc gtg        240
Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Arg Val           
65                  70                  75                  80            

aat aaa cat aaa ccg tgg ttg gaa cca aca tat cat ggg atc gtt acc        288
Asn Lys His Lys Pro Trp Leu Glu Pro Thr Tyr His Gly Ile Val Thr           
                85                  90                  95                

gaa aat gat aat aca gta ctt ctg gat cca cct ctc att gct ttg gac        336
Glu Asn Asp Asn Thr Val Leu Leu Asp Pro Pro Leu Ile Ala Leu Asp           
            100                 105                 110                   

aag gac gca ccc ctc agg ttc gct gaa tca ttc gaa gtt acc gtt acg        384
Lys Asp Ala Pro Leu Arg Phe Ala Glu Ser Phe Glu Val Thr Val Thr           
        115                 120                 125                       

aag gaa ggg gaa ata tgc ggt ttc aag atc cat ggt caa aac gtt cct        432
Lys Glu Gly Glu Ile Cys Gly Phe Lys Ile His Gly Gln Asn Val Pro           
    130                 135                 140                           

ttc gac gcc gtc gtg gtt gac aag agc acc ggc gaa ggg gtt ata aga        480
Phe Asp Ala Val Val Val Asp Lys Ser Thr Gly Glu Gly Val Ile Arg           
145                 150                 155                 160           

tct aag gaa aag ctc gat tgc gaa ctt caa aag gat tac agc ttt act        528
Ser Lys Glu Lys Leu Asp Cys Glu Leu Gln Lys Asp Tyr Ser Phe Thr           
                165                 170                 175               

ata caa gcg tac gac tgc ggc aaa ggg ccc gac ggg aca aat gtt aag        576
Ile Gln Ala Tyr Asp Cys Gly Lys Gly Pro Asp Gly Thr Asn Val Lys           
            180                 185                 190                   

aaa tcc cac aag gcc acg gtc cac atc caa gtc aat gat gtt aac gaa        624
Lys Ser His Lys Ala Thr Val His Ile Gln Val Asn Asp Val Asn Glu           
        195                 200                 205                       

tat gca cct gtt ttc aaa gag aaa agc tat aag gct act gtg ata gaa        672
Tyr Ala Pro Val Phe Lys Glu Lys Ser Tyr Lys Ala Thr Val Ile Glu           
    210                 215                 220                           

gga aaa caa tat gat agt atc ctg aga gtc gaa gct gtc gac gca gat        720
Gly Lys Gln Tyr Asp Ser Ile Leu Arg Val Glu Ala Val Asp Ala Asp           
225                 230                 235                 240           

tgt agc cca caa ttt tcc caa ata tgt tcc tat gag att ata aca cct        768
Cys Ser Pro Gln Phe Ser Gln Ile Cys Ser Tyr Glu Ile Ile Thr Pro           
                245                 250                 255               

gat gtc cct ttc acc gta gat aag gac gga tac atc aag aat act gaa        816
Asp Val Pro Phe Thr Val Asp Lys Asp Gly Tyr Ile Lys Asn Thr Glu           
            260                 265                 270                   

aag ctg aat tat ggt aaa gag cac cag tac aaa ctc acg gtg acg gcg        864
Lys Leu Asn Tyr Gly Lys Glu His Gln Tyr Lys Leu Thr Val Thr Ala           
        275                 280                 285                       

tac gat tgc gga aag aag cgt gca act gag gac gta ctt gtt aaa att        912
Tyr Asp Cys Gly Lys Lys Arg Ala Thr Glu Asp Val Leu Val Lys Ile           
    290                 295                 300                           

agt atc aaa ccg acg tgt aca cca ggc tgg cag ggc tgg aat aat cgg        960
Ser Ile Lys Pro Thr Cys Thr Pro Gly Trp Gln Gly Trp Asn Asn Arg           
305                 310                 315                 320           

atc gaa tac gaa ccc gga aca gga gca ctg gct gtg ttc cct aac att       1008
Ile Glu Tyr Glu Pro Gly Thr Gly Ala Leu Ala Val Phe Pro Asn Ile           
                325                 330                 335               

cat ctc gaa act tgc gat gaa cct gtg gca agc gtc caa gct acg gta       1056
His Leu Glu Thr Cys Asp Glu Pro Val Ala Ser Val Gln Ala Thr Val           
            340                 345                 350                   

gaa ctg gag aca tct cat att ggt aag gga tgt gat aga gat act tat       1104
Glu Leu Glu Thr Ser His Ile Gly Lys Gly Cys Asp Arg Asp Thr Tyr           
        355                 360                 365                       

agc gag aaa agc ctt cat cgc ttg tgc ggc gcc gca gcc gga aca gca       1152
Ser Glu Lys Ser Leu His Arg Leu Cys Gly Ala Ala Ala Gly Thr Ala           
    370                 375                 380                           

gaa ctc ttg cct tct ccc tct ggc agc ctt aat tgg act atg gga ttg       1200
Glu Leu Leu Pro Ser Pro Ser Gly Ser Leu Asn Trp Thr Met Gly Leu           
385                 390                 395                 400           

cct act gat aac ggt cat gat tcc gat caa gtc ttc gaa ttt aat gga       1248
Pro Thr Asp Asn Gly His Asp Ser Asp Gln Val Phe Glu Phe Asn Gly           
                405                 410                 415               

aca caa gct gta cgc att cct gac gga gtg gta agt gtt tct ccg aag       1296
Thr Gln Ala Val Arg Ile Pro Asp Gly Val Val Ser Val Ser Pro Lys           
            420                 425                 430                   

gaa ccc ttt aca att agc gta tgg atg cgc cac ggc ccc ttt gga cgg       1344
Glu Pro Phe Thr Ile Ser Val Trp Met Arg His Gly Pro Phe Gly Arg           
        435                 440                 445                       

aag aaa gaa act atc ctg tgt agc tca gac aag act gac atg aac cgc       1392
Lys Lys Glu Thr Ile Leu Cys Ser Ser Asp Lys Thr Asp Met Asn Arg           
    450                 455                 460                           

cat cat tat tct ttg tac gta cat ggt tgt cgt ctt att ttc ctg ttt       1440
His His Tyr Ser Leu Tyr Val His Gly Cys Arg Leu Ile Phe Leu Phe           
465                 470                 475                 480           

cgc caa gac cca tcc gaa gaa aag aag tat agg ccc gcc gaa ttt cat       1488
Arg Gln Asp Pro Ser Glu Glu Lys Lys Tyr Arg Pro Ala Glu Phe His           
                485                 490                 495               

tgg aaa ctc aac caa gtg tgc gac gaa gag tgg cat cat tat gtt ctg       1536
Trp Lys Leu Asn Gln Val Cys Asp Glu Glu Trp His His Tyr Val Leu           
            500                 505                 510                   

aac gtt gag ttt cca tcc gtc aca ctg tac gtc gac ggt acc agc cat       1584
Asn Val Glu Phe Pro Ser Val Thr Leu Tyr Val Asp Gly Thr Ser His           
        515                 520                 525                       

gaa cca ttt agt gtc aca gaa gac tat ccc ctg cac ccg agt aaa atc       1632
Glu Pro Phe Ser Val Thr Glu Asp Tyr Pro Leu His Pro Ser Lys Ile           
    530                 535                 540                           

gag acg caa ctg gtt gtc ggc gca tgt tgg cag gaa ttt agt ggc gtc       1680
Glu Thr Gln Leu Val Val Gly Ala Cys Trp Gln Glu Phe Ser Gly Val           
545                 550                 555                 560           

gag aac gat aac gag acc gaa ccc gtc acc gta gcg tcc gcc ggc ggg       1728
Glu Asn Asp Asn Glu Thr Glu Pro Val Thr Val Ala Ser Ala Gly Gly           
                565                 570                 575               

gat ctc cat atg acg caa ttc ttt cgg ggt aac ttg gcc ggg ctg aca       1776
Asp Leu His Met Thr Gln Phe Phe Arg Gly Asn Leu Ala Gly Leu Thr           
            580                 585                 590                   

ctg cgc tct ggc aag ctg gct gac aag aaa gtt att gat tgc ttg tac       1824
Leu Arg Ser Gly Lys Leu Ala Asp Lys Lys Val Ile Asp Cys Leu Tyr           
        595                 600                 605                       

acg tgt aaa gaa ggc ctt gat ctc caa gtt ctg gaa gat tca gga cga       1872
Thr Cys Lys Glu Gly Leu Asp Leu Gln Val Leu Glu Asp Ser Gly Arg           
    610                 615                 620                           

ggg gtc caa att cag gct cat cca tcc caa ctg gtg ctt aca ctg gaa       1920
Gly Val Gln Ile Gln Ala His Pro Ser Gln Leu Val Leu Thr Leu Glu           
625                 630                 635                 640           

ggc gag gat ctg gga gag ctg gac aaa gct atg caa cat att tcc tat       1968
Gly Glu Asp Leu Gly Glu Leu Asp Lys Ala Met Gln His Ile Ser Tyr           
                645                 650                 655               

ctc aat agt cgc caa ttt cca aca cct ggc atc cga cga ctg aag att       2016
Leu Asn Ser Arg Gln Phe Pro Thr Pro Gly Ile Arg Arg Leu Lys Ile           
            660                 665                 670                   

acg tca acc att aaa tgc ttc aat gaa gca aca tgt atc agc gtg cca       2064
Thr Ser Thr Ile Lys Cys Phe Asn Glu Ala Thr Cys Ile Ser Val Pro           
        675                 680                 685                       

cct gtg gac gga tat gtt atg gta ctg caa cct gaa gaa cca aag att       2112
Pro Val Asp Gly Tyr Val Met Val Leu Gln Pro Glu Glu Pro Lys Ile           
    690                 695                 700                           

tcc ctc tct ggg gtt cat cac ttc gca agg gcc gca agt gag ttc gag       2160
Ser Leu Ser Gly Val His His Phe Ala Arg Ala Ala Ser Glu Phe Glu           
705                 710                 715                 720           

tcc tct gag gga gtc ttt ctc ttt ccc gaa ctg cgg ata ata agt act       2208
Ser Ser Glu Gly Val Phe Leu Phe Pro Glu Leu Arg Ile Ile Ser Thr           
                725                 730                 735               

att aca agg gaa gtc gaa cca gag gga gat gga gcc gaa gat cca acc       2256
Ile Thr Arg Glu Val Glu Pro Glu Gly Asp Gly Ala Glu Asp Pro Thr           
            740                 745                 750                   

gtg cag gag tct ctc gta tca gaa gaa att gtc cat gat ctt gac acg       2304
Val Gln Glu Ser Leu Val Ser Glu Glu Ile Val His Asp Leu Asp Thr           
        755                 760                 765                       

tgc gaa gtg aca gta gaa ggg gaa gaa ctc aat cat gaa caa gaa tca       2352
Cys Glu Val Thr Val Glu Gly Glu Glu Leu Asn His Glu Gln Glu Ser           
    770                 775                 780                           

ttg gaa gta gat atg gca cga ttg caa caa aag gga atc gag gtc tcc       2400
Leu Glu Val Asp Met Ala Arg Leu Gln Gln Lys Gly Ile Glu Val Ser           
785                 790                 795                 800           

tca tcc gag ctt ggt atg act ttt act gga gta gat acg atg gct tcc       2448
Ser Ser Glu Leu Gly Met Thr Phe Thr Gly Val Asp Thr Met Ala Ser           
                805                 810                 815               

tat gaa gaa gtg ctg cat ctt ctc aga tac cgc aat tgg cac gcg cgt       2496
Tyr Glu Glu Val Leu His Leu Leu Arg Tyr Arg Asn Trp His Ala Arg           
            820                 825                 830                   

tct ctg ctg gac aga aaa ttc aaa ctg att tgt agc gaa ctt aac gga       2544
Ser Leu Leu Asp Arg Lys Phe Lys Leu Ile Cys Ser Glu Leu Asn Gly           
        835                 840                 845                       

cgg tac ata tct aat gag ttc aaa gta gaa gtt aac gtg att cat act       2592
Arg Tyr Ile Ser Asn Glu Phe Lys Val Glu Val Asn Val Ile His Thr           
    850                 855                 860                           

gca aat cct atg gag cat gcg gcc gct gcc gcc gct caa cct caa ttt       2640
Ala Asn Pro Met Glu His Ala Ala Ala Ala Ala Ala Gln Pro Gln Phe           
865                 870                 875                 880           

gtc cat ccc gag cat agg tca ttc gtg gat ctc tct ggt cat aat ttg       2688
Val His Pro Glu His Arg Ser Phe Val Asp Leu Ser Gly His Asn Leu           
                885                 890                 895               

gca aat cca cat ccc ttt gct gtg gtt cca tct aca gca act gta gtt       2736
Ala Asn Pro His Pro Phe Ala Val Val Pro Ser Thr Ala Thr Val Val           
            900                 905                 910                   

att gta gta tgt gtg tcc ttt ctc gtc ttt atg atc ata ttg ggc gtc       2784
Ile Val Val Cys Val Ser Phe Leu Val Phe Met Ile Ile Leu Gly Val           
        915                 920                 925                       

ttc cgc ata aga gcg gcc cac agg aga aca atg agg gac caa gat aca       2832
Phe Arg Ile Arg Ala Ala His Arg Arg Thr Met Arg Asp Gln Asp Thr           
    930                 935                 940                           

gga aaa gaa aat gaa atg gat tgg gat gat agc gca ctc aca ata acg       2880
Gly Lys Glu Asn Glu Met Asp Trp Asp Asp Ser Ala Leu Thr Ile Thr           
945                 950                 955                 960           

gtg aat cca atg gaa acg tac gaa gat caa cat tct agc gaa gaa gaa       2928
Val Asn Pro Met Glu Thr Tyr Glu Asp Gln His Ser Ser Glu Glu Glu           
                965                 970                 975               

gaa gag gaa gag gaa gag gaa gag tca gaa gat gga gaa gag gaa gac       2976
Glu Glu Glu Glu Glu Glu Glu Glu Ser Glu Asp Gly Glu Glu Glu Asp           
            980                 985                 990                   

gat att aca tca gct gaa agc gaa  tct tca gaa gaa gaa  gaa ggt gaa     3024
Asp Ile Thr Ser Ala Glu Ser Glu  Ser Ser Glu Glu Glu  Glu Gly Glu         
        995                 1000                 1005                     

caa ggt  gat cct caa aat gcc  aca cgc caa caa caa  ctc gaa tgg        3069
Gln Gly  Asp Pro Gln Asn Ala  Thr Arg Gln Gln Gln  Leu Glu Trp            
    1010                 1015                 1020                        

gac gat  tct aca ttg tcc tat                                          3090
Asp Asp  Ser Thr Leu Ser Tyr                                              
    1025                 1030                                             


<210>  48
<211>  1030
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu Leu Trp 
1               5                   10                  15      


Pro Met Val Trp Ala Thr His Arg Pro Pro Met Trp Ser Pro Val Trp 
            20                  25                  30          


Pro Gly Gly Gly Ser Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp 
        35                  40                  45              


His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Asn Ser Thr Met 
    50                  55                  60                  


Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Arg Val 
65                  70                  75                  80  


Asn Lys His Lys Pro Trp Leu Glu Pro Thr Tyr His Gly Ile Val Thr 
                85                  90                  95      


Glu Asn Asp Asn Thr Val Leu Leu Asp Pro Pro Leu Ile Ala Leu Asp 
            100                 105                 110         


Lys Asp Ala Pro Leu Arg Phe Ala Glu Ser Phe Glu Val Thr Val Thr 
        115                 120                 125             


Lys Glu Gly Glu Ile Cys Gly Phe Lys Ile His Gly Gln Asn Val Pro 
    130                 135                 140                 


Phe Asp Ala Val Val Val Asp Lys Ser Thr Gly Glu Gly Val Ile Arg 
145                 150                 155                 160 


Ser Lys Glu Lys Leu Asp Cys Glu Leu Gln Lys Asp Tyr Ser Phe Thr 
                165                 170                 175     


Ile Gln Ala Tyr Asp Cys Gly Lys Gly Pro Asp Gly Thr Asn Val Lys 
            180                 185                 190         


Lys Ser His Lys Ala Thr Val His Ile Gln Val Asn Asp Val Asn Glu 
        195                 200                 205             


Tyr Ala Pro Val Phe Lys Glu Lys Ser Tyr Lys Ala Thr Val Ile Glu 
    210                 215                 220                 


Gly Lys Gln Tyr Asp Ser Ile Leu Arg Val Glu Ala Val Asp Ala Asp 
225                 230                 235                 240 


Cys Ser Pro Gln Phe Ser Gln Ile Cys Ser Tyr Glu Ile Ile Thr Pro 
                245                 250                 255     


Asp Val Pro Phe Thr Val Asp Lys Asp Gly Tyr Ile Lys Asn Thr Glu 
            260                 265                 270         


Lys Leu Asn Tyr Gly Lys Glu His Gln Tyr Lys Leu Thr Val Thr Ala 
        275                 280                 285             


Tyr Asp Cys Gly Lys Lys Arg Ala Thr Glu Asp Val Leu Val Lys Ile 
    290                 295                 300                 


Ser Ile Lys Pro Thr Cys Thr Pro Gly Trp Gln Gly Trp Asn Asn Arg 
305                 310                 315                 320 


Ile Glu Tyr Glu Pro Gly Thr Gly Ala Leu Ala Val Phe Pro Asn Ile 
                325                 330                 335     


His Leu Glu Thr Cys Asp Glu Pro Val Ala Ser Val Gln Ala Thr Val 
            340                 345                 350         


Glu Leu Glu Thr Ser His Ile Gly Lys Gly Cys Asp Arg Asp Thr Tyr 
        355                 360                 365             


Ser Glu Lys Ser Leu His Arg Leu Cys Gly Ala Ala Ala Gly Thr Ala 
    370                 375                 380                 


Glu Leu Leu Pro Ser Pro Ser Gly Ser Leu Asn Trp Thr Met Gly Leu 
385                 390                 395                 400 


Pro Thr Asp Asn Gly His Asp Ser Asp Gln Val Phe Glu Phe Asn Gly 
                405                 410                 415     


Thr Gln Ala Val Arg Ile Pro Asp Gly Val Val Ser Val Ser Pro Lys 
            420                 425                 430         


Glu Pro Phe Thr Ile Ser Val Trp Met Arg His Gly Pro Phe Gly Arg 
        435                 440                 445             


Lys Lys Glu Thr Ile Leu Cys Ser Ser Asp Lys Thr Asp Met Asn Arg 
    450                 455                 460                 


His His Tyr Ser Leu Tyr Val His Gly Cys Arg Leu Ile Phe Leu Phe 
465                 470                 475                 480 


Arg Gln Asp Pro Ser Glu Glu Lys Lys Tyr Arg Pro Ala Glu Phe His 
                485                 490                 495     


Trp Lys Leu Asn Gln Val Cys Asp Glu Glu Trp His His Tyr Val Leu 
            500                 505                 510         


Asn Val Glu Phe Pro Ser Val Thr Leu Tyr Val Asp Gly Thr Ser His 
        515                 520                 525             


Glu Pro Phe Ser Val Thr Glu Asp Tyr Pro Leu His Pro Ser Lys Ile 
    530                 535                 540                 


Glu Thr Gln Leu Val Val Gly Ala Cys Trp Gln Glu Phe Ser Gly Val 
545                 550                 555                 560 


Glu Asn Asp Asn Glu Thr Glu Pro Val Thr Val Ala Ser Ala Gly Gly 
                565                 570                 575     


Asp Leu His Met Thr Gln Phe Phe Arg Gly Asn Leu Ala Gly Leu Thr 
            580                 585                 590         


Leu Arg Ser Gly Lys Leu Ala Asp Lys Lys Val Ile Asp Cys Leu Tyr 
        595                 600                 605             


Thr Cys Lys Glu Gly Leu Asp Leu Gln Val Leu Glu Asp Ser Gly Arg 
    610                 615                 620                 


Gly Val Gln Ile Gln Ala His Pro Ser Gln Leu Val Leu Thr Leu Glu 
625                 630                 635                 640 


Gly Glu Asp Leu Gly Glu Leu Asp Lys Ala Met Gln His Ile Ser Tyr 
                645                 650                 655     


Leu Asn Ser Arg Gln Phe Pro Thr Pro Gly Ile Arg Arg Leu Lys Ile 
            660                 665                 670         


Thr Ser Thr Ile Lys Cys Phe Asn Glu Ala Thr Cys Ile Ser Val Pro 
        675                 680                 685             


Pro Val Asp Gly Tyr Val Met Val Leu Gln Pro Glu Glu Pro Lys Ile 
    690                 695                 700                 


Ser Leu Ser Gly Val His His Phe Ala Arg Ala Ala Ser Glu Phe Glu 
705                 710                 715                 720 


Ser Ser Glu Gly Val Phe Leu Phe Pro Glu Leu Arg Ile Ile Ser Thr 
                725                 730                 735     


Ile Thr Arg Glu Val Glu Pro Glu Gly Asp Gly Ala Glu Asp Pro Thr 
            740                 745                 750         


Val Gln Glu Ser Leu Val Ser Glu Glu Ile Val His Asp Leu Asp Thr 
        755                 760                 765             


Cys Glu Val Thr Val Glu Gly Glu Glu Leu Asn His Glu Gln Glu Ser 
    770                 775                 780                 


Leu Glu Val Asp Met Ala Arg Leu Gln Gln Lys Gly Ile Glu Val Ser 
785                 790                 795                 800 


Ser Ser Glu Leu Gly Met Thr Phe Thr Gly Val Asp Thr Met Ala Ser 
                805                 810                 815     


Tyr Glu Glu Val Leu His Leu Leu Arg Tyr Arg Asn Trp His Ala Arg 
            820                 825                 830         


Ser Leu Leu Asp Arg Lys Phe Lys Leu Ile Cys Ser Glu Leu Asn Gly 
        835                 840                 845             


Arg Tyr Ile Ser Asn Glu Phe Lys Val Glu Val Asn Val Ile His Thr 
    850                 855                 860                 


Ala Asn Pro Met Glu His Ala Ala Ala Ala Ala Ala Gln Pro Gln Phe 
865                 870                 875                 880 


Val His Pro Glu His Arg Ser Phe Val Asp Leu Ser Gly His Asn Leu 
                885                 890                 895     


Ala Asn Pro His Pro Phe Ala Val Val Pro Ser Thr Ala Thr Val Val 
            900                 905                 910         


Ile Val Val Cys Val Ser Phe Leu Val Phe Met Ile Ile Leu Gly Val 
        915                 920                 925             


Phe Arg Ile Arg Ala Ala His Arg Arg Thr Met Arg Asp Gln Asp Thr 
    930                 935                 940                 


Gly Lys Glu Asn Glu Met Asp Trp Asp Asp Ser Ala Leu Thr Ile Thr 
945                 950                 955                 960 


Val Asn Pro Met Glu Thr Tyr Glu Asp Gln His Ser Ser Glu Glu Glu 
                965                 970                 975     


Glu Glu Glu Glu Glu Glu Glu Glu Ser Glu Asp Gly Glu Glu Glu Asp 
            980                 985                 990         


Asp Ile Thr Ser Ala Glu Ser Glu  Ser Ser Glu Glu Glu  Glu Gly Glu 
        995                 1000                 1005             


Gln Gly  Asp Pro Gln Asn Ala  Thr Arg Gln Gln Gln  Leu Glu Trp 
    1010                 1015                 1020             


Asp Asp  Ser Thr Leu Ser Tyr  
    1025                 1030 


<210>  49
<211>  1410
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1410)

<400>  49
atg tgg tgg cga ttg tgg tgg ctc ctt ctt ctt ctg ctc ctg ctt tgg         48
Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu Leu Trp           
1               5                   10                  15                

cca atg gtg tgg gcc gac tac aaa gac cac gac ggg gat tat aaa gat         96
Pro Met Val Trp Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp           
            20                  25                  30                    

cat gac atc gat tac aag gat gac gat gat aag acc cac gtc agc cca        144
His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Thr His Val Ser Pro           
        35                  40                  45                        

aac cag ggc ggc ctg cct tca ggt ggc ggt agt gga aac tcc acc atg        192
Asn Gln Gly Gly Leu Pro Ser Gly Gly Gly Ser Gly Asn Ser Thr Met           
    50                  55                  60                            

ggc tct ggc ggc ggt ggc ggc tct ggc gga gga ggc tca ttg gaa ctt        240
Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Leu           
65                  70                  75                  80            

aat ttg aca gat tca gaa aat gcc act tgc ctt tat gca aaa tgg cag        288
Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln           
                85                  90                  95                

atg aat ttc aca gta cgc tat gaa act aca aat aaa act tat aaa act        336
Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr           
            100                 105                 110                   

gta acc att tca gac cat ggc act gtg aca tat aat gga agc att tgt        384
Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys           
        115                 120                 125                       

ggg gat gat cag aat ggt ccc aaa ata gca gtg cag ttc gga cct ggc        432
Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly           
    130                 135                 140                           

ttt tcc tgg att gcg aat ttt acc aag gca gca tct act tat tca att        480
Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile           
145                 150                 155                 160           

gac agc gtc tca ttt tcc tac aac act ggt gat aac aca aca ttt cct        528
Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro           
                165                 170                 175               

gat gct gaa gat aaa gga att ctt act gtt gat gaa ctt ttg gcc atc        576
Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile           
            180                 185                 190                   

aga att cca ttg aat gac ctt ttt aga tgc aat agt tta tca act ttg        624
Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu           
        195                 200                 205                       

gaa aag aat gat gtt gtc caa cac tac tgg gat gtt ctt gta caa gct        672
Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala           
    210                 215                 220                           

ttt gtc caa aat ggc aca gtg agc aca aat gag ttc ctg tgt gat aaa        720
Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys           
225                 230                 235                 240           

gac aaa act tca aca gtg gca ccc acc ata cac acc act gtg cca tct        768
Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser           
                245                 250                 255               

cct act aca aca cct act cca aag gaa aaa cca gaa gct gga acc tat        816
Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr           
            260                 265                 270                   

tca gtt aat aat ggc aat gat act tgt ctg ctg gct acc atg ggg ctg        864
Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu           
        275                 280                 285                       

cag ctg aac atc act cag gat aag gtt gct tca gtt att aac atc aac        912
Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn           
    290                 295                 300                           

ccc aat aca act cac tcc aca ggc agc tgc cgt tct cac act gct cta        960
Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu           
305                 310                 315                 320           

ctt aga ctc aat agc agc acc att aag tat cta gac ttt gtc ttt gct       1008
Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala           
                325                 330                 335               

gtg aaa aat gaa aac cga ttt tat ctg aag gaa gtg aac atc agc atg       1056
Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met           
            340                 345                 350                   

tat ttg gtt aat ggc tcc gtt ttc agc att gca aat aac aat ctc agc       1104
Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser           
        355                 360                 365                       

tac tgg gat gcc ccc ctg gga agt tct tat atg tgc aac aaa gag cag       1152
Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln           
    370                 375                 380                           

act gtt tca gtg tct gga gca ttt cag ata aat acc ttt gat cta agg       1200
Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg           
385                 390                 395                 400           

gtt cag cct ttc aat gtg aca caa gga aag tat tct aca gcc caa gag       1248
Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Glu           
                405                 410                 415               

tgt tcg ctg gat gat gac acc att cta atc cca att ata gtt ggt gct       1296
Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile Val Gly Ala           
            420                 425                 430                   

ggt ctt tca ggc ttg att atc gtt ata gtg att gct agc tcc cac tgg       1344
Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Ser Ser His Trp           
        435                 440                 445                       

tgt tgt aag aag gag gtt cag gag aca cgg cgc gag cgc cgc agg ctc       1392
Cys Cys Lys Lys Glu Val Gln Glu Thr Arg Arg Glu Arg Arg Arg Leu           
    450                 455                 460                           

atg tcg atg gag atg gac                                               1410
Met Ser Met Glu Met Asp                                                   
465                 470                                                   


<210>  50
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu Leu Trp 
1               5                   10                  15      


Pro Met Val Trp Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp 
            20                  25                  30          


His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Thr His Val Ser Pro 
        35                  40                  45              


Asn Gln Gly Gly Leu Pro Ser Gly Gly Gly Ser Gly Asn Ser Thr Met 
    50                  55                  60                  


Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Leu 
65                  70                  75                  80  


Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln 
                85                  90                  95      


Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr 
            100                 105                 110         


Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys 
        115                 120                 125             


Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly 
    130                 135                 140                 


Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile 
145                 150                 155                 160 


Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro 
                165                 170                 175     


Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile 
            180                 185                 190         


Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu 
        195                 200                 205             


Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala 
    210                 215                 220                 


Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys 
225                 230                 235                 240 


Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser 
                245                 250                 255     


Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr 
            260                 265                 270         


Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu 
        275                 280                 285             


Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn 
    290                 295                 300                 


Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu 
305                 310                 315                 320 


Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala 
                325                 330                 335     


Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met 
            340                 345                 350         


Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser 
        355                 360                 365             


Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln 
    370                 375                 380                 


Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg 
385                 390                 395                 400 


Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Glu 
                405                 410                 415     


Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile Val Gly Ala 
            420                 425                 430         


Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Ser Ser His Trp 
        435                 440                 445             


Cys Cys Lys Lys Glu Val Gln Glu Thr Arg Arg Glu Arg Arg Arg Leu 
    450                 455                 460                 


Met Ser Met Glu Met Asp 
465                 470 


<210>  51
<211>  1443
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1443)

<400>  51
atg tgg tgg cga ttg tgg tgg ctc ctt ctt ctt ctg ctc ctg ctt tgg         48
Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu Leu Trp           
1               5                   10                  15                

cca atg gtg tgg gcc gac tac aaa gac cac gac ggg gat tat aaa gat         96
Pro Met Val Trp Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp           
            20                  25                  30                    

cat gac atc gat tac aag gat gac gat gat aag acc cac gtc agc cca        144
His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Thr His Val Ser Pro           
        35                  40                  45                        

aac cag ggc ggc ctg cct tca ggt ggc ggt agt gga aac tcc acc atg        192
Asn Gln Gly Gly Leu Pro Ser Gly Gly Gly Ser Gly Asn Ser Thr Met           
    50                  55                  60                            

ggc tct ggc ggc ggt ggc ggc tct ggc gga gga ggc tca ttg gaa ctt        240
Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Leu           
65                  70                  75                  80            

aat ttg aca gat tca gaa aat gcc act tgc ctt tat gca aaa tgg cag        288
Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln           
                85                  90                  95                

atg aat ttc aca gta cgc tat gaa act aca aat aaa act tat aaa act        336
Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr           
            100                 105                 110                   

gta acc att tca gac cat ggc act gtg aca tat aat gga agc att tgt        384
Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys           
        115                 120                 125                       

ggg gat gat cag aat ggt ccc aaa ata gca gtg cag ttc gga cct ggc        432
Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly           
    130                 135                 140                           

ttt tcc tgg att gcg aat ttt acc aag gca gca tct act tat tca att        480
Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile           
145                 150                 155                 160           

gac agc gtc tca ttt tcc tac aac act ggt gat aac aca aca ttt cct        528
Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro           
                165                 170                 175               

gat gct gaa gat aaa gga att ctt act gtt gat gaa ctt ttg gcc atc        576
Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile           
            180                 185                 190                   

aga att cca ttg aat gac ctt ttt aga tgc aat agt tta tca act ttg        624
Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu           
        195                 200                 205                       

gaa aag aat gat gtt gtc caa cac tac tgg gat gtt ctt gta caa gct        672
Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala           
    210                 215                 220                           

ttt gtc caa aat ggc aca gtg agc aca aat gag ttc ctg tgt gat aaa        720
Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys           
225                 230                 235                 240           

gac aaa act tca aca gtg gca ccc acc ata cac acc act gtg cca tct        768
Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser           
                245                 250                 255               

cct act aca aca cct act cca aag gaa aaa cca gaa gct gga acc tat        816
Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr           
            260                 265                 270                   

tca gtt aat aat ggc aat gat act tgt ctg ctg gct acc atg ggg ctg        864
Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu           
        275                 280                 285                       

cag ctg aac atc act cag gat aag gtt gct tca gtt att aac atc aac        912
Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn           
    290                 295                 300                           

ccc aat aca act cac tcc aca ggc agc tgc cgt tct cac act gct cta        960
Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu           
305                 310                 315                 320           

ctt aga ctc aat agc agc acc att aag tat cta gac ttt gtc ttt gct       1008
Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala           
                325                 330                 335               

gtg aaa aat gaa aac cga ttt tat ctg aag gaa gtg aac atc agc atg       1056
Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met           
            340                 345                 350                   

tat ttg gtt aat ggc tcc gtt ttc agc att gca aat aac aat ctc agc       1104
Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser           
        355                 360                 365                       

tac tgg gat gcc ccc ctg gga agt tct tat atg tgc aac aaa gag cag       1152
Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln           
    370                 375                 380                           

act gtt tca gtg tct gga gca ttt cag ata aat acc ttt gat cta agg       1200
Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg           
385                 390                 395                 400           

gtt cag cct ttc aat gtg aca caa gga aag tat tct aca gcc caa gag       1248
Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Glu           
                405                 410                 415               

tgt tcg ctg gat gat gac acc att cta atc cca att ata gtt ggt gct       1296
Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile Val Gly Ala           
            420                 425                 430                   

ggt ctt tca ggc ttg att atc gtt ata gtg att gct aag tgc ggc ttc       1344
Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Lys Cys Gly Phe           
        435                 440                 445                       

ttc aag cga gcc cgc act cgc gcc ctg tat gaa gct aag agg cag aag       1392
Phe Lys Arg Ala Arg Thr Arg Ala Leu Tyr Glu Ala Lys Arg Gln Lys           
    450                 455                 460                           

gcg gag atg aag agc cag ccg tca gag aca gag agg ctg acc gac gac       1440
Ala Glu Met Lys Ser Gln Pro Ser Glu Thr Glu Arg Leu Thr Asp Asp           
465                 470                 475                 480           

tac                                                                   1443
Tyr                                                                       
                                                                          


<210>  52
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu Leu Trp 
1               5                   10                  15      


Pro Met Val Trp Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp 
            20                  25                  30          


His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Thr His Val Ser Pro 
        35                  40                  45              


Asn Gln Gly Gly Leu Pro Ser Gly Gly Gly Ser Gly Asn Ser Thr Met 
    50                  55                  60                  


Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Leu 
65                  70                  75                  80  


Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln 
                85                  90                  95      


Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr 
            100                 105                 110         


Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys 
        115                 120                 125             


Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly 
    130                 135                 140                 


Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile 
145                 150                 155                 160 


Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro 
                165                 170                 175     


Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile 
            180                 185                 190         


Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu 
        195                 200                 205             


Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala 
    210                 215                 220                 


Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys 
225                 230                 235                 240 


Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser 
                245                 250                 255     


Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr 
            260                 265                 270         


Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu 
        275                 280                 285             


Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn 
    290                 295                 300                 


Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu 
305                 310                 315                 320 


Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala 
                325                 330                 335     


Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met 
            340                 345                 350         


Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser 
        355                 360                 365             


Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln 
    370                 375                 380                 


Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg 
385                 390                 395                 400 


Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Glu 
                405                 410                 415     


Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile Val Gly Ala 
            420                 425                 430         


Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Lys Cys Gly Phe 
        435                 440                 445             


Phe Lys Arg Ala Arg Thr Arg Ala Leu Tyr Glu Ala Lys Arg Gln Lys 
    450                 455                 460                 


Ala Glu Met Lys Ser Gln Pro Ser Glu Thr Glu Arg Leu Thr Asp Asp 
465                 470                 475                 480 


Tyr 
    


<210>  53
<211>  1479
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1479)

<400>  53
atg tgg tgg cga ttg tgg tgg ctc ctt ctt ctt ctg ctc ctg ctt tgg         48
Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu Leu Trp           
1               5                   10                  15                

cca atg gtg tgg gcc gac tac aaa gac cac gac ggg gat tat aaa gat         96
Pro Met Val Trp Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp           
            20                  25                  30                    

cat gac atc gat tac aag gat gac gat gat aag acc cac gtc agc cca        144
His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Thr His Val Ser Pro           
        35                  40                  45                        

aac cag ggc ggc ctg cct tca ggt ggc ggt agt gga aac tcc acc atg        192
Asn Gln Gly Gly Leu Pro Ser Gly Gly Gly Ser Gly Asn Ser Thr Met           
    50                  55                  60                            

ggc tct ggc ggc ggt ggc ggc tct ggc gga gga ggc tca ttg gaa ctt        240
Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Leu           
65                  70                  75                  80            

aat ttg aca gat tca gaa aat gcc act tgc ctt tat gca aaa tgg cag        288
Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln           
                85                  90                  95                

atg aat ttc aca gta cgc tat gaa act aca aat aaa act tat aaa act        336
Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr           
            100                 105                 110                   

gta acc att tca gac cat ggc act gtg aca tat aat gga agc att tgt        384
Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys           
        115                 120                 125                       

ggg gat gat cag aat ggt ccc aaa ata gca gtg cag ttc gga cct ggc        432
Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly           
    130                 135                 140                           

ttt tcc tgg att gcg aat ttt acc aag gca gca tct act tat tca att        480
Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile           
145                 150                 155                 160           

gac agc gtc tca ttt tcc tac aac act ggt gat aac aca aca ttt cct        528
Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro           
                165                 170                 175               

gat gct gaa gat aaa gga att ctt act gtt gat gaa ctt ttg gcc atc        576
Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile           
            180                 185                 190                   

aga att cca ttg aat gac ctt ttt aga tgc aat agt tta tca act ttg        624
Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu           
        195                 200                 205                       

gaa aag aat gat gtt gtc caa cac tac tgg gat gtt ctt gta caa gct        672
Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala           
    210                 215                 220                           

ttt gtc caa aat ggc aca gtg agc aca aat gag ttc ctg tgt gat aaa        720
Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys           
225                 230                 235                 240           

gac aaa act tca aca gtg gca ccc acc ata cac acc act gtg cca tct        768
Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser           
                245                 250                 255               

cct act aca aca cct act cca aag gaa aaa cca gaa gct gga acc tat        816
Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr           
            260                 265                 270                   

tca gtt aat aat ggc aat gat act tgt ctg ctg gct acc atg ggg ctg        864
Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu           
        275                 280                 285                       

cag ctg aac atc act cag gat aag gtt gct tca gtt att aac atc aac        912
Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn           
    290                 295                 300                           

ccc aat aca act cac tcc aca ggc agc tgc cgt tct cac act gct cta        960
Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu           
305                 310                 315                 320           

ctt aga ctc aat agc agc acc att aag tat cta gac ttt gtc ttt gct       1008
Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala           
                325                 330                 335               

gtg aaa aat gaa aac cga ttt tat ctg aag gaa gtg aac atc agc atg       1056
Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met           
            340                 345                 350                   

tat ttg gtt aat ggc tcc gtt ttc agc att gca aat aac aat ctc agc       1104
Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser           
        355                 360                 365                       

tac tgg gat gcc ccc ctg gga agt tct tat atg tgc aac aaa gag cag       1152
Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln           
    370                 375                 380                           

act gtt tca gtg tct gga gca ttt cag ata aat acc ttt gat cta agg       1200
Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg           
385                 390                 395                 400           

gtt cag cct ttc aat gtg aca caa gga aag tat tct aca gcc caa gag       1248
Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Glu           
                405                 410                 415               

tgt tcg ctg gat gat gac acc att cta atc cca att ata gtt ggt gct       1296
Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile Val Gly Ala           
            420                 425                 430                   

ggt ctt tca ggc ttg att atc gtt ata gtg att gct gtg atg cag aga       1344
Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Val Met Gln Arg           
        435                 440                 445                       

ctc ttt ccc cgc atc cct cac atg aaa gac ccc atc ggt gac agc ttc       1392
Leu Phe Pro Arg Ile Pro His Met Lys Asp Pro Ile Gly Asp Ser Phe           
    450                 455                 460                           

caa aac gac aag ctg gtg gtc tgg gag gcg ggc aaa gcc ggc ctg gag       1440
Gln Asn Asp Lys Leu Val Val Trp Glu Ala Gly Lys Ala Gly Leu Glu           
465                 470                 475                 480           

gag tgt ctg gtg act gaa gta cag gtc gtg cag aaa act                   1479
Glu Cys Leu Val Thr Glu Val Gln Val Val Gln Lys Thr                       
                485                 490                                   


<210>  54
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu Leu Trp 
1               5                   10                  15      


Pro Met Val Trp Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp 
            20                  25                  30          


His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Thr His Val Ser Pro 
        35                  40                  45              


Asn Gln Gly Gly Leu Pro Ser Gly Gly Gly Ser Gly Asn Ser Thr Met 
    50                  55                  60                  


Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Leu 
65                  70                  75                  80  


Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln 
                85                  90                  95      


Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr 
            100                 105                 110         


Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys 
        115                 120                 125             


Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly 
    130                 135                 140                 


Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile 
145                 150                 155                 160 


Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro 
                165                 170                 175     


Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile 
            180                 185                 190         


Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu 
        195                 200                 205             


Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala 
    210                 215                 220                 


Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys 
225                 230                 235                 240 


Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser 
                245                 250                 255     


Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr 
            260                 265                 270         


Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu 
        275                 280                 285             


Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn 
    290                 295                 300                 


Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu 
305                 310                 315                 320 


Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala 
                325                 330                 335     


Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met 
            340                 345                 350         


Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser 
        355                 360                 365             


Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln 
    370                 375                 380                 


Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg 
385                 390                 395                 400 


Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Glu 
                405                 410                 415     


Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile Val Gly Ala 
            420                 425                 430         


Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Val Met Gln Arg 
        435                 440                 445             


Leu Phe Pro Arg Ile Pro His Met Lys Asp Pro Ile Gly Asp Ser Phe 
    450                 455                 460                 


Gln Asn Asp Lys Leu Val Val Trp Glu Ala Gly Lys Ala Gly Leu Glu 
465                 470                 475                 480 


Glu Cys Leu Val Thr Glu Val Gln Val Val Gln Lys Thr 
                485                 490             


<210>  55
<211>  1539
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1539)

<400>  55
atg tgg tgg cga ttg tgg tgg ctc ctt ctt ctt ctg ctc ctg ctt tgg         48
Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu Leu Trp           
1               5                   10                  15                

cca atg gtg tgg gcc gac tac aaa gac cac gac ggg gat tat aaa gat         96
Pro Met Val Trp Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp           
            20                  25                  30                    

cat gac atc gat tac aag gat gac gat gat aag acc cac gtc agc cca        144
His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Thr His Val Ser Pro           
        35                  40                  45                        

aac cag ggc ggc ctg cct tca ggt ggc ggt agt gga aac tcc acc atg        192
Asn Gln Gly Gly Leu Pro Ser Gly Gly Gly Ser Gly Asn Ser Thr Met           
    50                  55                  60                            

ggc tct ggc ggc ggt ggc ggc tct ggc gga gga ggc tca ttg gaa ctt        240
Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Leu           
65                  70                  75                  80            

aat ttg aca gat tca gaa aat gcc act tgc ctt tat gca aaa tgg cag        288
Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln           
                85                  90                  95                

atg aat ttc aca gta cgc tat gaa act aca aat aaa act tat aaa act        336
Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr           
            100                 105                 110                   

gta acc att tca gac cat ggc act gtg aca tat aat gga agc att tgt        384
Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys           
        115                 120                 125                       

ggg gat gat cag aat ggt ccc aaa ata gca gtg cag ttc gga cct ggc        432
Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly           
    130                 135                 140                           

ttt tcc tgg att gcg aat ttt acc aag gca gca tct act tat tca att        480
Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile           
145                 150                 155                 160           

gac agc gtc tca ttt tcc tac aac act ggt gat aac aca aca ttt cct        528
Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro           
                165                 170                 175               

gat gct gaa gat aaa gga att ctt act gtt gat gaa ctt ttg gcc atc        576
Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile           
            180                 185                 190                   

aga att cca ttg aat gac ctt ttt aga tgc aat agt tta tca act ttg        624
Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu           
        195                 200                 205                       

gaa aag aat gat gtt gtc caa cac tac tgg gat gtt ctt gta caa gct        672
Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala           
    210                 215                 220                           

ttt gtc caa aat ggc aca gtg agc aca aat gag ttc ctg tgt gat aaa        720
Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys           
225                 230                 235                 240           

gac aaa act tca aca gtg gca ccc acc ata cac acc act gtg cca tct        768
Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser           
                245                 250                 255               

cct act aca aca cct act cca aag gaa aaa cca gaa gct gga acc tat        816
Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr           
            260                 265                 270                   

tca gtt aat aat ggc aat gat act tgt ctg ctg gct acc atg ggg ctg        864
Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu           
        275                 280                 285                       

cag ctg aac atc act cag gat aag gtt gct tca gtt att aac atc aac        912
Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn           
    290                 295                 300                           

ccc aat aca act cac tcc aca ggc agc tgc cgt tct cac act gct cta        960
Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu           
305                 310                 315                 320           

ctt aga ctc aat agc agc acc att aag tat cta gac ttt gtc ttt gct       1008
Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala           
                325                 330                 335               

gtg aaa aat gaa aac cga ttt tat ctg aag gaa gtg aac atc agc atg       1056
Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met           
            340                 345                 350                   

tat ttg gtt aat ggc tcc gtt ttc agc att gca aat aac aat ctc agc       1104
Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser           
        355                 360                 365                       

tac tgg gat gcc ccc ctg gga agt tct tat atg tgc aac aaa gag cag       1152
Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln           
    370                 375                 380                           

act gtt tca gtg tct gga gca ttt cag ata aat acc ttt gat cta agg       1200
Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg           
385                 390                 395                 400           

gtt cag cct ttc aat gtg aca caa gga aag tat tct aca gcc caa gag       1248
Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Glu           
                405                 410                 415               

tgt tcg ctg gat gat gac acc att cta atc cca att ata gtt ggt gct       1296
Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile Val Gly Ala           
            420                 425                 430                   

ggt ctt tca ggc ttg att atc gtt ata gtg att gct cgc ctc tcc cgc       1344
Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Arg Leu Ser Arg           
        435                 440                 445                       

aag ggc cac atg tac ccc gtg cgt aat tac tcc ccc acc gag atg gtc       1392
Lys Gly His Met Tyr Pro Val Arg Asn Tyr Ser Pro Thr Glu Met Val           
    450                 455                 460                           

tgc atc tca tcc ctg ttg cct gat ggg ggt gag ggg ccc tct gcc aca       1440
Cys Ile Ser Ser Leu Leu Pro Asp Gly Gly Glu Gly Pro Ser Ala Thr           
465                 470                 475                 480           

gcc aat ggg ggc ctg tcc aag gcc aag agc ccg ggc ctg acg cca gag       1488
Ala Asn Gly Gly Leu Ser Lys Ala Lys Ser Pro Gly Leu Thr Pro Glu           
                485                 490                 495               

ccc agg gag gac cgt gag ggg gat gac ctc acc ctg cac agc ttc ctc       1536
Pro Arg Glu Asp Arg Glu Gly Asp Asp Leu Thr Leu His Ser Phe Leu           
            500                 505                 510                   

cct                                                                   1539
Pro                                                                       
                                                                          


<210>  56
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu Leu Trp 
1               5                   10                  15      


Pro Met Val Trp Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp 
            20                  25                  30          


His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Thr His Val Ser Pro 
        35                  40                  45              


Asn Gln Gly Gly Leu Pro Ser Gly Gly Gly Ser Gly Asn Ser Thr Met 
    50                  55                  60                  


Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Leu 
65                  70                  75                  80  


Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln 
                85                  90                  95      


Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr 
            100                 105                 110         


Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys 
        115                 120                 125             


Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly 
    130                 135                 140                 


Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile 
145                 150                 155                 160 


Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro 
                165                 170                 175     


Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile 
            180                 185                 190         


Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu 
        195                 200                 205             


Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala 
    210                 215                 220                 


Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys 
225                 230                 235                 240 


Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser 
                245                 250                 255     


Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr 
            260                 265                 270         


Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu 
        275                 280                 285             


Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn 
    290                 295                 300                 


Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu 
305                 310                 315                 320 


Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala 
                325                 330                 335     


Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met 
            340                 345                 350         


Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser 
        355                 360                 365             


Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln 
    370                 375                 380                 


Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg 
385                 390                 395                 400 


Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Glu 
                405                 410                 415     


Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile Val Gly Ala 
            420                 425                 430         


Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Arg Leu Ser Arg 
        435                 440                 445             


Lys Gly His Met Tyr Pro Val Arg Asn Tyr Ser Pro Thr Glu Met Val 
    450                 455                 460                 


Cys Ile Ser Ser Leu Leu Pro Asp Gly Gly Glu Gly Pro Ser Ala Thr 
465                 470                 475                 480 


Ala Asn Gly Gly Leu Ser Lys Ala Lys Ser Pro Gly Leu Thr Pro Glu 
                485                 490                 495     


Pro Arg Glu Asp Arg Glu Gly Asp Asp Leu Thr Leu His Ser Phe Leu 
            500                 505                 510         


Pro 
    


<210>  57
<211>  1470
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1470)

<400>  57
atg tgg tgg cga ttg tgg tgg ctc ctt ctt ctt ctg ctc ctg ctt tgg         48
Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu Leu Trp           
1               5                   10                  15                

cca atg gtg tgg gcc gac tac aaa gac cac gac ggg gat tat aaa gat         96
Pro Met Val Trp Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp           
            20                  25                  30                    

cat gac atc gat tac aag gat gac gat gat aag acc cac gtc agc cca        144
His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Thr His Val Ser Pro           
        35                  40                  45                        

aac cag ggc ggc ctg cct tca ggt ggc ggt agt gga aac tcc acc atg        192
Asn Gln Gly Gly Leu Pro Ser Gly Gly Gly Ser Gly Asn Ser Thr Met           
    50                  55                  60                            

ggc tct ggc ggc ggt ggc ggc tct ggc gga gga ggc tca ttg gaa ctt        240
Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Leu           
65                  70                  75                  80            

aat ttg aca gat tca gaa aat gcc act tgc ctt tat gca aaa tgg cag        288
Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln           
                85                  90                  95                

atg aat ttc aca gta cgc tat gaa act aca aat aaa act tat aaa act        336
Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr           
            100                 105                 110                   

gta acc att tca gac cat ggc act gtg aca tat aat gga agc att tgt        384
Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys           
        115                 120                 125                       

ggg gat gat cag aat ggt ccc aaa ata gca gtg cag ttc gga cct ggc        432
Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly           
    130                 135                 140                           

ttt tcc tgg att gcg aat ttt acc aag gca gca tct act tat tca att        480
Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile           
145                 150                 155                 160           

gac agc gtc tca ttt tcc tac aac act ggt gat aac aca aca ttt cct        528
Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro           
                165                 170                 175               

gat gct gaa gat aaa gga att ctt act gtt gat gaa ctt ttg gcc atc        576
Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile           
            180                 185                 190                   

aga att cca ttg aat gac ctt ttt aga tgc aat agt tta tca act ttg        624
Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu           
        195                 200                 205                       

gaa aag aat gat gtt gtc caa cac tac tgg gat gtt ctt gta caa gct        672
Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala           
    210                 215                 220                           

ttt gtc caa aat ggc aca gtg agc aca aat gag ttc ctg tgt gat aaa        720
Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys           
225                 230                 235                 240           

gac aaa act tca aca gtg gca ccc acc ata cac acc act gtg cca tct        768
Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser           
                245                 250                 255               

cct act aca aca cct act cca aag gaa aaa cca gaa gct gga acc tat        816
Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr           
            260                 265                 270                   

tca gtt aat aat ggc aat gat act tgt ctg ctg gct acc atg ggg ctg        864
Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu           
        275                 280                 285                       

cag ctg aac atc act cag gat aag gtt gct tca gtt att aac atc aac        912
Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn           
    290                 295                 300                           

ccc aat aca act cac tcc aca ggc agc tgc cgt tct cac act gct cta        960
Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu           
305                 310                 315                 320           

ctt aga ctc aat agc agc acc att aag tat cta gac ttt gtc ttt gct       1008
Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala           
                325                 330                 335               

gtg aaa aat gaa aac cga ttt tat ctg aag gaa gtg aac atc agc atg       1056
Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met           
            340                 345                 350                   

tat ttg gtt aat ggc tcc gtt ttc agc att gca aat aac aat ctc agc       1104
Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser           
        355                 360                 365                       

tac tgg gat gcc ccc ctg gga agt tct tat atg tgc aac aaa gag cag       1152
Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln           
    370                 375                 380                           

act gtt tca gtg tct gga gca ttt cag ata aat acc ttt gat cta agg       1200
Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg           
385                 390                 395                 400           

gtt cag cct ttc aat gtg aca caa gga aag tat tct aca gcc caa gag       1248
Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Glu           
                405                 410                 415               

tgt tcg ctg gat gat gac acc att cta atc cca att ata gtt ggt gct       1296
Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile Val Gly Ala           
            420                 425                 430                   

ggt ctt tca ggc ttg att atc gtt ata gtg att gct ctt tta atg ata       1344
Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Leu Leu Met Ile           
        435                 440                 445                       

att cat gac aga agg gag ttt gct aaa ttt gaa aag gag aaa atg aat       1392
Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys Glu Lys Met Asn           
    450                 455                 460                           

gcc aaa tgg gac acg ggt gaa aat cct att tat aag agt gcc gta aca       1440
Ala Lys Trp Asp Thr Gly Glu Asn Pro Ile Tyr Lys Ser Ala Val Thr           
465                 470                 475                 480           

act gtg gtc aat ccg aag tat gag gga aaa                               1470
Thr Val Val Asn Pro Lys Tyr Glu Gly Lys                                   
                485                 490                                   


<210>  58
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu Leu Trp 
1               5                   10                  15      


Pro Met Val Trp Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp 
            20                  25                  30          


His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Thr His Val Ser Pro 
        35                  40                  45              


Asn Gln Gly Gly Leu Pro Ser Gly Gly Gly Ser Gly Asn Ser Thr Met 
    50                  55                  60                  


Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Leu 
65                  70                  75                  80  


Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln 
                85                  90                  95      


Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr 
            100                 105                 110         


Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys 
        115                 120                 125             


Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly 
    130                 135                 140                 


Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile 
145                 150                 155                 160 


Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro 
                165                 170                 175     


Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile 
            180                 185                 190         


Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu 
        195                 200                 205             


Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala 
    210                 215                 220                 


Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys 
225                 230                 235                 240 


Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser 
                245                 250                 255     


Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr 
            260                 265                 270         


Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu 
        275                 280                 285             


Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn 
    290                 295                 300                 


Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu 
305                 310                 315                 320 


Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala 
                325                 330                 335     


Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met 
            340                 345                 350         


Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser 
        355                 360                 365             


Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln 
    370                 375                 380                 


Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg 
385                 390                 395                 400 


Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Glu 
                405                 410                 415     


Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile Val Gly Ala 
            420                 425                 430         


Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Leu Leu Met Ile 
        435                 440                 445             


Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys Glu Lys Met Asn 
    450                 455                 460                 


Ala Lys Trp Asp Thr Gly Glu Asn Pro Ile Tyr Lys Ser Ala Val Thr 
465                 470                 475                 480 


Thr Val Val Asn Pro Lys Tyr Glu Gly Lys 
                485                 490 


<210>  59
<211>  1635
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1635)

<400>  59
atg tgg tgg cga ttg tgg tgg ctc ctt ctt ctt ctg ctc ctg ctt tgg         48
Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu Leu Trp           
1               5                   10                  15                

cca atg gtg tgg gcc gac tac aaa gac cac gac ggg gat tat aaa gat         96
Pro Met Val Trp Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp           
            20                  25                  30                    

cat gac atc gat tac aag gat gac gat gat aag acc cac gtc agc cca        144
His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Thr His Val Ser Pro           
        35                  40                  45                        

aac cag ggc ggc ctg cct tca ggt ggc ggt agt gga aac tcc acc atg        192
Asn Gln Gly Gly Leu Pro Ser Gly Gly Gly Ser Gly Asn Ser Thr Met           
    50                  55                  60                            

ggc tct ggc ggc ggt ggc ggc tct ggc gga gga ggc tca ttg gaa ctt        240
Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Leu           
65                  70                  75                  80            

aat ttg aca gat tca gaa aat gcc act tgc ctt tat gca aaa tgg cag        288
Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln           
                85                  90                  95                

atg aat ttc aca gta cgc tat gaa act aca aat aaa act tat aaa act        336
Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr           
            100                 105                 110                   

gta acc att tca gac cat ggc act gtg aca tat aat gga agc att tgt        384
Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys           
        115                 120                 125                       

ggg gat gat cag aat ggt ccc aaa ata gca gtg cag ttc gga cct ggc        432
Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly           
    130                 135                 140                           

ttt tcc tgg att gcg aat ttt acc aag gca gca tct act tat tca att        480
Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile           
145                 150                 155                 160           

gac agc gtc tca ttt tcc tac aac act ggt gat aac aca aca ttt cct        528
Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro           
                165                 170                 175               

gat gct gaa gat aaa gga att ctt act gtt gat gaa ctt ttg gcc atc        576
Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile           
            180                 185                 190                   

aga att cca ttg aat gac ctt ttt aga tgc aat agt tta tca act ttg        624
Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu           
        195                 200                 205                       

gaa aag aat gat gtt gtc caa cac tac tgg gat gtt ctt gta caa gct        672
Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala           
    210                 215                 220                           

ttt gtc caa aat ggc aca gtg agc aca aat gag ttc ctg tgt gat aaa        720
Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys           
225                 230                 235                 240           

gac aaa act tca aca gtg gca ccc acc ata cac acc act gtg cca tct        768
Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser           
                245                 250                 255               

cct act aca aca cct act cca aag gaa aaa cca gaa gct gga acc tat        816
Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr           
            260                 265                 270                   

tca gtt aat aat ggc aat gat act tgt ctg ctg gct acc atg ggg ctg        864
Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu           
        275                 280                 285                       

cag ctg aac atc act cag gat aag gtt gct tca gtt att aac atc aac        912
Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn           
    290                 295                 300                           

ccc aat aca act cac tcc aca ggc agc tgc cgt tct cac act gct cta        960
Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu           
305                 310                 315                 320           

ctt aga ctc aat agc agc acc att aag tat cta gac ttt gtc ttt gct       1008
Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala           
                325                 330                 335               

gtg aaa aat gaa aac cga ttt tat ctg aag gaa gtg aac atc agc atg       1056
Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met           
            340                 345                 350                   

tat ttg gtt aat ggc tcc gtt ttc agc att gca aat aac aat ctc agc       1104
Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser           
        355                 360                 365                       

tac tgg gat gcc ccc ctg gga agt tct tat atg tgc aac aaa gag cag       1152
Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln           
    370                 375                 380                           

act gtt tca gtg tct gga gca ttt cag ata aat acc ttt gat cta agg       1200
Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg           
385                 390                 395                 400           

gtt cag cct ttc aat gtg aca caa gga aag tat tct aca gcc caa gag       1248
Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Glu           
                405                 410                 415               

tgt tcg ctg gat gat gac acc att cta atc cca att ata gtt ggt gct       1296
Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile Val Gly Ala           
            420                 425                 430                   

ggt ctt tca ggc ttg att atc gtt ata gtg att gct cgg atc cgg gcc       1344
Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Arg Ile Arg Ala           
        435                 440                 445                       

gca cat cgg cgg acc atg cgg gat cag gac acc ggg aag gag aac gag       1392
Ala His Arg Arg Thr Met Arg Asp Gln Asp Thr Gly Lys Glu Asn Glu           
    450                 455                 460                           

atg gac tgg gac gac tct gcc ctg acc atc acc gtc aac ccc atg gag       1440
Met Asp Trp Asp Asp Ser Ala Leu Thr Ile Thr Val Asn Pro Met Glu           
465                 470                 475                 480           

acc tat gag gac cag cac agc agt gag gag gag gag gaa gag gaa gag       1488
Thr Tyr Glu Asp Gln His Ser Ser Glu Glu Glu Glu Glu Glu Glu Glu           
                485                 490                 495               

gaa gag gaa agc gag gac ggc gaa gaa gag gat gac atc acc agc gcc       1536
Glu Glu Glu Ser Glu Asp Gly Glu Glu Glu Asp Asp Ile Thr Ser Ala           
            500                 505                 510                   

gag tcg gag agc agc gag gag gag gag ggg gag cag ggc gac ccc cag       1584
Glu Ser Glu Ser Ser Glu Glu Glu Glu Gly Glu Gln Gly Asp Pro Gln           
        515                 520                 525                       

aac gca acc cgg cag cag cag ctg gag tgg gat gac tcc acc ctc agc       1632
Asn Ala Thr Arg Gln Gln Gln Leu Glu Trp Asp Asp Ser Thr Leu Ser           
    530                 535                 540                           

tac                                                                   1635
Tyr                                                                       
545                                                                       


<210>  60
<211>  545
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu Leu Trp 
1               5                   10                  15      


Pro Met Val Trp Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp 
            20                  25                  30          


His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Thr His Val Ser Pro 
        35                  40                  45              


Asn Gln Gly Gly Leu Pro Ser Gly Gly Gly Ser Gly Asn Ser Thr Met 
    50                  55                  60                  


Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Leu 
65                  70                  75                  80  


Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln 
                85                  90                  95      


Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr 
            100                 105                 110         


Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys 
        115                 120                 125             


Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly 
    130                 135                 140                 


Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile 
145                 150                 155                 160 


Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro 
                165                 170                 175     


Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile 
            180                 185                 190         


Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu 
        195                 200                 205             


Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala 
    210                 215                 220                 


Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys 
225                 230                 235                 240 


Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser 
                245                 250                 255     


Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr 
            260                 265                 270         


Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu 
        275                 280                 285             


Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn 
    290                 295                 300                 


Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu 
305                 310                 315                 320 


Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala 
                325                 330                 335     


Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met 
            340                 345                 350         


Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser 
        355                 360                 365             


Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln 
    370                 375                 380                 


Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg 
385                 390                 395                 400 


Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Glu 
                405                 410                 415     


Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile Val Gly Ala 
            420                 425                 430         


Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Arg Ile Arg Ala 
        435                 440                 445             


Ala His Arg Arg Thr Met Arg Asp Gln Asp Thr Gly Lys Glu Asn Glu 
    450                 455                 460                 


Met Asp Trp Asp Asp Ser Ala Leu Thr Ile Thr Val Asn Pro Met Glu 
465                 470                 475                 480 


Thr Tyr Glu Asp Gln His Ser Ser Glu Glu Glu Glu Glu Glu Glu Glu 
                485                 490                 495     


Glu Glu Glu Ser Glu Asp Gly Glu Glu Glu Asp Asp Ile Thr Ser Ala 
            500                 505                 510         


Glu Ser Glu Ser Ser Glu Glu Glu Glu Gly Glu Gln Gly Asp Pro Gln 
        515                 520                 525             


Asn Ala Thr Arg Gln Gln Gln Leu Glu Trp Asp Asp Ser Thr Leu Ser 
    530                 535                 540                 


Tyr 
545 


<210>  61
<211>  1344
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1344)

<400>  61
atg tgg tgg cga ttg tgg tgg ctc ctt ctt ctt ctg ctc ctg ctt tgg         48
Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu Leu Trp           
1               5                   10                  15                

cca atg gtg tgg gcc gac tac aaa gac cac gac ggg gat tat aaa gat         96
Pro Met Val Trp Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp           
            20                  25                  30                    

cat gac atc gat tac aag gat gac gat gat aag acc cac gtc agc cca        144
His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Thr His Val Ser Pro           
        35                  40                  45                        

aac cag ggc ggc ctg cct tca ggt ggc ggt agt gga aac tcc acc atg        192
Asn Gln Gly Gly Leu Pro Ser Gly Gly Gly Ser Gly Asn Ser Thr Met           
    50                  55                  60                            

ggc tct ggc ggc ggt ggc ggc tct ggc gga gga ggc tca ttg gaa ctt        240
Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Leu           
65                  70                  75                  80            

aat ttg aca gat tca gaa aat gcc act tgc ctt tat gca aaa tgg cag        288
Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln           
                85                  90                  95                

atg aat ttc aca gta cgc tat gaa act aca aat aaa act tat aaa act        336
Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr           
            100                 105                 110                   

gta acc att tca gac cat ggc act gtg aca tat aat gga agc att tgt        384
Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys           
        115                 120                 125                       

ggg gat gat cag aat ggt ccc aaa ata gca gtg cag ttc gga cct ggc        432
Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly           
    130                 135                 140                           

ttt tcc tgg att gcg aat ttt acc aag gca gca tct act tat tca att        480
Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile           
145                 150                 155                 160           

gac agc gtc tca ttt tcc tac aac act ggt gat aac aca aca ttt cct        528
Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro           
                165                 170                 175               

gat gct gaa gat aaa gga att ctt act gtt gat gaa ctt ttg gcc atc        576
Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile           
            180                 185                 190                   

aga att cca ttg aat gac ctt ttt aga tgc aat agt tta tca act ttg        624
Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu           
        195                 200                 205                       

gaa aag aat gat gtt gtc caa cac tac tgg gat gtt ctt gta caa gct        672
Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala           
    210                 215                 220                           

ttt gtc caa aat ggc aca gtg agc aca aat gag ttc ctg tgt gat aaa        720
Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys           
225                 230                 235                 240           

gac aaa act tca aca gtg gca ccc acc ata cac acc act gtg cca tct        768
Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser           
                245                 250                 255               

cct act aca aca cct act cca aag gaa aaa cca gaa gct gga acc tat        816
Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr           
            260                 265                 270                   

tca gtt aat aat ggc aat gat act tgt ctg ctg gct acc atg ggg ctg        864
Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu           
        275                 280                 285                       

cag ctg aac atc act cag gat aag gtt gct tca gtt att aac atc aac        912
Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn           
    290                 295                 300                           

ccc aat aca act cac tcc aca ggc agc tgc cgt tct cac act gct cta        960
Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu           
305                 310                 315                 320           

ctt aga ctc aat agc agc acc att aag tat cta gac ttt gtc ttt gct       1008
Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala           
                325                 330                 335               

gtg aaa aat gaa aac cga ttt tat ctg aag gaa gtg aac atc agc atg       1056
Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met           
            340                 345                 350                   

tat ttg gtt aat ggc tcc gtt ttc agc att gca aat aac aat ctc agc       1104
Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser           
        355                 360                 365                       

tac tgg gat gcc ccc ctg gga agt tct tat atg tgc aac aaa gag cag       1152
Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln           
    370                 375                 380                           

act gtt tca gtg tct gga gca ttt cag ata aat acc ttt gat cta agg       1200
Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg           
385                 390                 395                 400           

gtt cag cct ttc aat gtg aca caa gga aag tat tct aca gcc caa gag       1248
Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Glu           
                405                 410                 415               

tgt tcg ctg gat gat gac acc att cta atc cca att ata gtt ggt gct       1296
Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile Val Gly Ala           
            420                 425                 430                   

ggt ctt tca ggc ttg att atc gtt ata gtg att gct aag aag cca cgt       1344
Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Lys Lys Pro Arg           
        435                 440                 445                       


<210>  62
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu Leu Trp 
1               5                   10                  15      


Pro Met Val Trp Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp 
            20                  25                  30          


His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Thr His Val Ser Pro 
        35                  40                  45              


Asn Gln Gly Gly Leu Pro Ser Gly Gly Gly Ser Gly Asn Ser Thr Met 
    50                  55                  60                  


Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Leu 
65                  70                  75                  80  


Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln 
                85                  90                  95      


Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr 
            100                 105                 110         


Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys 
        115                 120                 125             


Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly 
    130                 135                 140                 


Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile 
145                 150                 155                 160 


Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro 
                165                 170                 175     


Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile 
            180                 185                 190         


Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu 
        195                 200                 205             


Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala 
    210                 215                 220                 


Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys 
225                 230                 235                 240 


Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser 
                245                 250                 255     


Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr 
            260                 265                 270         


Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu 
        275                 280                 285             


Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn 
    290                 295                 300                 


Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu 
305                 310                 315                 320 


Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala 
                325                 330                 335     


Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met 
            340                 345                 350         


Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser 
        355                 360                 365             


Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln 
    370                 375                 380                 


Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg 
385                 390                 395                 400 


Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Glu 
                405                 410                 415     


Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile Val Gly Ala 
            420                 425                 430         


Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Lys Lys Pro Arg 
        435                 440                 445             


<210>  63
<211>  36
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(36)

<400>  63
acc cac cgg ccg ccc atg tgg agc cct gtg tgg ccc                         36
Thr His Arg Pro Pro Met Trp Ser Pro Val Trp Pro                           
1               5                   10                                    


<210>  64
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  64

Thr His Arg Pro Pro Met Trp Ser Pro Val Trp Pro 
1               5                   10          


<210>  65
<211>  36
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(36)

<400>  65
acc cac gtc agc cca aac cag ggc ggc ctg cct tca                         36
Thr His Val Ser Pro Asn Gln Gly Gly Leu Pro Ser                           
1               5                   10                                    


<210>  66
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  66

Thr His Val Ser Pro Asn Gln Gly Gly Leu Pro Ser 
1               5                   10          


<210>  67
<211>  1146
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1146)

<400>  67
ctc gaa ctt aat ttg acc gat tca gag aat gcc aca tgc ctt tat gcg         48
Leu Glu Leu Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala           
1               5                   10                  15                

aaa tgg cag atg aat ttc act gtt cgg tat gaa acc aca aat aaa act         96
Lys Trp Gln Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr           
            20                  25                  30                    

tat aaa acc gtt acc ata agc gac cat gga act gtg acc tat aat gga        144
Tyr Lys Thr Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly           
        35                  40                  45                        

agc ata tgt gga gat gat cag aat ggt ccc aaa att gct gtt cag ttc        192
Ser Ile Cys Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe           
    50                  55                  60                            

gga cct ggt ttc tcc tgg att gct aat ttt act aag gca gcc tct acc        240
Gly Pro Gly Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr           
65                  70                  75                  80            

tat tcc ata gac tca gtt tct ttt agt tac aac aca ggg gat aac aca        288
Tyr Ser Ile Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr           
                85                  90                  95                

acg ttt cct gat gcc gaa gat aaa ggc ata ctc acc gtt gat gaa ctc        336
Thr Phe Pro Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu           
            100                 105                 110                   

ttg gcc atc aga ata cct ctt aat gac ctg ttt aga tgc aat agc ctc        384
Leu Ala Ile Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu           
        115                 120                 125                       

tcc acc ctg gag aag aat gat gtg gta caa cac tac tgg gat gtg ttg        432
Ser Thr Leu Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu           
    130                 135                 140                           

gtt caa gct ttt gta caa aat ggg acc gtc tct aca aat gag ttc ctc        480
Val Gln Ala Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu           
145                 150                 155                 160           

tgt gat aaa gac aaa acc agt act gtg gca cca acc ata cac aca aca        528
Cys Asp Lys Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr           
                165                 170                 175               

gtg cca tct cca acg acc acc cct aca ccc aag gag aaa cct gaa gcc        576
Val Pro Ser Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala           
            180                 185                 190                   

ggt aca tat tca gtg aat aat gga aat gat aca tgc ctt ctg gcc acc        624
Gly Thr Tyr Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr           
        195                 200                 205                       

atg ggc ctt cag ctc aac atc act cag gat aag gtc gct tca gtc att        672
Met Gly Leu Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile           
    210                 215                 220                           

aac att aac ccc aat act act cac tct aca ggc tct tgc agg agt cac        720
Asn Ile Asn Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His           
225                 230                 235                 240           

acg gcg ctc ctg cgg ttg aat agc agc acc att aag tat ctt gac ttt        768
Thr Ala Leu Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe           
                245                 250                 255               

gtc ttt gct gtc aag aat gag aac aga ttt tat ctg aaa gag gtc aac        816
Val Phe Ala Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn           
            260                 265                 270                   

atc tct atg tat ttg gtc aat ggg agt gtg ttc tcc att gct aat aac        864
Ile Ser Met Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn           
        275                 280                 285                       

aat ctc agc tac tgg gat gcc cct ctg ggt tct tcc tat atg tgc aac        912
Asn Leu Ser Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn           
    290                 295                 300                           

aaa gag cag act gtt tca gtg tcc ggc gca ttt cag att aat act ttt        960
Lys Glu Gln Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe           
305                 310                 315                 320           

gat ctt cgg gtg cag cct ttc aat gtg aca caa gga aag tat tcc acc       1008
Asp Leu Arg Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr           
                325                 330                 335               

gcc caa gag tgt tct ttg gat gat gac acc ata ctg atc ccc atc att       1056
Ala Gln Glu Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile           
            340                 345                 350                   

gta ggt gcc ggc ctg agc ggc ctt att atc gtt atc gtc att gca tac       1104
Val Gly Ala Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Tyr           
        355                 360                 365                       

gtg att gga cgg cgg aaa tct tat gcc ggt tat cag acg ctt               1146
Val Ile Gly Arg Arg Lys Ser Tyr Ala Gly Tyr Gln Thr Leu                   
    370                 375                 380                           


<210>  68
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  68

Leu Glu Leu Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala 
1               5                   10                  15      


Lys Trp Gln Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr 
            20                  25                  30          


Tyr Lys Thr Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly 
        35                  40                  45              


Ser Ile Cys Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe 
    50                  55                  60                  


Gly Pro Gly Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr 
65                  70                  75                  80  


Tyr Ser Ile Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr 
                85                  90                  95      


Thr Phe Pro Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu 
            100                 105                 110         


Leu Ala Ile Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu 
        115                 120                 125             


Ser Thr Leu Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu 
    130                 135                 140                 


Val Gln Ala Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu 
145                 150                 155                 160 


Cys Asp Lys Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr 
                165                 170                 175     


Val Pro Ser Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala 
            180                 185                 190         


Gly Thr Tyr Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr 
        195                 200                 205             


Met Gly Leu Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile 
    210                 215                 220                 


Asn Ile Asn Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His 
225                 230                 235                 240 


Thr Ala Leu Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe 
                245                 250                 255     


Val Phe Ala Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn 
            260                 265                 270         


Ile Ser Met Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn 
        275                 280                 285             


Asn Leu Ser Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn 
    290                 295                 300                 


Lys Glu Gln Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe 
305                 310                 315                 320 


Asp Leu Arg Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr 
                325                 330                 335     


Ala Gln Glu Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile 
            340                 345                 350         


Val Gly Ala Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Tyr 
        355                 360                 365             


Val Ile Gly Arg Arg Lys Ser Tyr Ala Gly Tyr Gln Thr Leu 
    370                 375                 380         


<210>  69
<211>  2859
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(2859)

<400>  69
gca cgc gtg aat aaa cat aaa ccg tgg ttg gaa cca aca tat cat ggg         48
Ala Arg Val Asn Lys His Lys Pro Trp Leu Glu Pro Thr Tyr His Gly           
1               5                   10                  15                

atc gtt acc gaa aat gat aat aca gta ctt ctg gat cca cct ctc att         96
Ile Val Thr Glu Asn Asp Asn Thr Val Leu Leu Asp Pro Pro Leu Ile           
            20                  25                  30                    

gct ttg gac aag gac gca ccc ctc agg ttc gct gaa tca ttc gaa gtt        144
Ala Leu Asp Lys Asp Ala Pro Leu Arg Phe Ala Glu Ser Phe Glu Val           
        35                  40                  45                        

acc gtt acg aag gaa ggg gaa ata tgc ggt ttc aag atc cat ggt caa        192
Thr Val Thr Lys Glu Gly Glu Ile Cys Gly Phe Lys Ile His Gly Gln           
    50                  55                  60                            

aac gtt cct ttc gac gcc gtc gtg gtt gac aag agc acc ggc gaa ggg        240
Asn Val Pro Phe Asp Ala Val Val Val Asp Lys Ser Thr Gly Glu Gly           
65                  70                  75                  80            

gtt ata aga tct aag gaa aag ctc gat tgc gaa ctt caa aag gat tac        288
Val Ile Arg Ser Lys Glu Lys Leu Asp Cys Glu Leu Gln Lys Asp Tyr           
                85                  90                  95                

agc ttt act ata caa gcg tac gac tgc ggc aaa ggg ccc gac ggg aca        336
Ser Phe Thr Ile Gln Ala Tyr Asp Cys Gly Lys Gly Pro Asp Gly Thr           
            100                 105                 110                   

aat gtt aag aaa tcc cac aag gcc acg gtc cac atc caa gtc aat gat        384
Asn Val Lys Lys Ser His Lys Ala Thr Val His Ile Gln Val Asn Asp           
        115                 120                 125                       

gtt aac gaa tat gca cct gtt ttc aaa gag aaa agc tat aag gct act        432
Val Asn Glu Tyr Ala Pro Val Phe Lys Glu Lys Ser Tyr Lys Ala Thr           
    130                 135                 140                           

gtg ata gaa gga aaa caa tat gat agt atc ctg aga gtc gaa gct gtc        480
Val Ile Glu Gly Lys Gln Tyr Asp Ser Ile Leu Arg Val Glu Ala Val           
145                 150                 155                 160           

gac gca gat tgt agc cca caa ttt tcc caa ata tgt tcc tat gag att        528
Asp Ala Asp Cys Ser Pro Gln Phe Ser Gln Ile Cys Ser Tyr Glu Ile           
                165                 170                 175               

ata aca cct gat gtc cct ttc acc gta gat aag gac gga tac atc aag        576
Ile Thr Pro Asp Val Pro Phe Thr Val Asp Lys Asp Gly Tyr Ile Lys           
            180                 185                 190                   

aat act gaa aag ctg aat tat ggt aaa gag cac cag tac aaa ctc acg        624
Asn Thr Glu Lys Leu Asn Tyr Gly Lys Glu His Gln Tyr Lys Leu Thr           
        195                 200                 205                       

gtg acg gcg tac gat tgc gga aag aag cgt gca act gag gac gta ctt        672
Val Thr Ala Tyr Asp Cys Gly Lys Lys Arg Ala Thr Glu Asp Val Leu           
    210                 215                 220                           

gtt aaa att agt atc aaa ccg acg tgt aca cca ggc tgg cag ggc tgg        720
Val Lys Ile Ser Ile Lys Pro Thr Cys Thr Pro Gly Trp Gln Gly Trp           
225                 230                 235                 240           

aat aat cgg atc gaa tac gaa ccc gga aca gga gca ctg gct gtg ttc        768
Asn Asn Arg Ile Glu Tyr Glu Pro Gly Thr Gly Ala Leu Ala Val Phe           
                245                 250                 255               

cct aac att cat ctc gaa act tgc gat gaa cct gtg gca agc gtc caa        816
Pro Asn Ile His Leu Glu Thr Cys Asp Glu Pro Val Ala Ser Val Gln           
            260                 265                 270                   

gct acg gta gaa ctg gag aca tct cat att ggt aag gga tgt gat aga        864
Ala Thr Val Glu Leu Glu Thr Ser His Ile Gly Lys Gly Cys Asp Arg           
        275                 280                 285                       

gat act tat agc gag aaa agc ctt cat cgc ttg tgc ggc gcc gca gcc        912
Asp Thr Tyr Ser Glu Lys Ser Leu His Arg Leu Cys Gly Ala Ala Ala           
    290                 295                 300                           

gga aca gca gaa ctc ttg cct tct ccc tct ggc agc ctt aat tgg act        960
Gly Thr Ala Glu Leu Leu Pro Ser Pro Ser Gly Ser Leu Asn Trp Thr           
305                 310                 315                 320           

atg gga ttg cct act gat aac ggt cat gat tcc gat caa gtc ttc gaa       1008
Met Gly Leu Pro Thr Asp Asn Gly His Asp Ser Asp Gln Val Phe Glu           
                325                 330                 335               

ttt aat gga aca caa gct gta cgc att cct gac gga gtg gta agt gtt       1056
Phe Asn Gly Thr Gln Ala Val Arg Ile Pro Asp Gly Val Val Ser Val           
            340                 345                 350                   

tct ccg aag gaa ccc ttt aca att agc gta tgg atg cgc cac ggc ccc       1104
Ser Pro Lys Glu Pro Phe Thr Ile Ser Val Trp Met Arg His Gly Pro           
        355                 360                 365                       

ttt gga cgg aag aaa gaa act atc ctg tgt agc tca gac aag act gac       1152
Phe Gly Arg Lys Lys Glu Thr Ile Leu Cys Ser Ser Asp Lys Thr Asp           
    370                 375                 380                           

atg aac cgc cat cat tat tct ttg tac gta cat ggt tgt cgt ctt att       1200
Met Asn Arg His His Tyr Ser Leu Tyr Val His Gly Cys Arg Leu Ile           
385                 390                 395                 400           

ttc ctg ttt cgc caa gac cca tcc gaa gaa aag aag tat agg ccc gcc       1248
Phe Leu Phe Arg Gln Asp Pro Ser Glu Glu Lys Lys Tyr Arg Pro Ala           
                405                 410                 415               

gaa ttt cat tgg aaa ctc aac caa gtg tgc gac gaa gag tgg cat cat       1296
Glu Phe His Trp Lys Leu Asn Gln Val Cys Asp Glu Glu Trp His His           
            420                 425                 430                   

tat gtt ctg aac gtt gag ttt cca tcc gtc aca ctg tac gtc gac ggt       1344
Tyr Val Leu Asn Val Glu Phe Pro Ser Val Thr Leu Tyr Val Asp Gly           
        435                 440                 445                       

acc agc cat gaa cca ttt agt gtc aca gaa gac tat ccc ctg cac ccg       1392
Thr Ser His Glu Pro Phe Ser Val Thr Glu Asp Tyr Pro Leu His Pro           
    450                 455                 460                           

agt aaa atc gag acg caa ctg gtt gtc ggc gca tgt tgg cag gaa ttt       1440
Ser Lys Ile Glu Thr Gln Leu Val Val Gly Ala Cys Trp Gln Glu Phe           
465                 470                 475                 480           

agt ggc gtc gag aac gat aac gag acc gaa ccc gtc acc gta gcg tcc       1488
Ser Gly Val Glu Asn Asp Asn Glu Thr Glu Pro Val Thr Val Ala Ser           
                485                 490                 495               

gcc ggc ggg gat ctc cat atg acg caa ttc ttt cgg ggt aac ttg gcc       1536
Ala Gly Gly Asp Leu His Met Thr Gln Phe Phe Arg Gly Asn Leu Ala           
            500                 505                 510                   

ggg ctg aca ctg cgc tct ggc aag ctg gct gac aag aaa gtt att gat       1584
Gly Leu Thr Leu Arg Ser Gly Lys Leu Ala Asp Lys Lys Val Ile Asp           
        515                 520                 525                       

tgc ttg tac acg tgt aaa gaa ggc ctt gat ctc caa gtt ctg gaa gat       1632
Cys Leu Tyr Thr Cys Lys Glu Gly Leu Asp Leu Gln Val Leu Glu Asp           
    530                 535                 540                           

tca gga cga ggg gtc caa att cag gct cat cca tcc caa ctg gtg ctt       1680
Ser Gly Arg Gly Val Gln Ile Gln Ala His Pro Ser Gln Leu Val Leu           
545                 550                 555                 560           

aca ctg gaa ggc gag gat ctg gga gag ctg gac aaa gct atg caa cat       1728
Thr Leu Glu Gly Glu Asp Leu Gly Glu Leu Asp Lys Ala Met Gln His           
                565                 570                 575               

att tcc tat ctc aat agt cgc caa ttt cca aca cct ggc atc cga cga       1776
Ile Ser Tyr Leu Asn Ser Arg Gln Phe Pro Thr Pro Gly Ile Arg Arg           
            580                 585                 590                   

ctg aag att acg tca acc att aaa tgc ttc aat gaa gca aca tgt atc       1824
Leu Lys Ile Thr Ser Thr Ile Lys Cys Phe Asn Glu Ala Thr Cys Ile           
        595                 600                 605                       

agc gtg cca cct gtg gac gga tat gtt atg gta ctg caa cct gaa gaa       1872
Ser Val Pro Pro Val Asp Gly Tyr Val Met Val Leu Gln Pro Glu Glu           
    610                 615                 620                           

cca aag att tcc ctc tct ggg gtt cat cac ttc gca agg gcc gca agt       1920
Pro Lys Ile Ser Leu Ser Gly Val His His Phe Ala Arg Ala Ala Ser           
625                 630                 635                 640           

gag ttc gag tcc tct gag gga gtc ttt ctc ttt ccc gaa ctg cgg ata       1968
Glu Phe Glu Ser Ser Glu Gly Val Phe Leu Phe Pro Glu Leu Arg Ile           
                645                 650                 655               

ata agt act att aca agg gaa gtc gaa cca gag gga gat gga gcc gaa       2016
Ile Ser Thr Ile Thr Arg Glu Val Glu Pro Glu Gly Asp Gly Ala Glu           
            660                 665                 670                   

gat cca acc gtg cag gag tct ctc gta tca gaa gaa att gtc cat gat       2064
Asp Pro Thr Val Gln Glu Ser Leu Val Ser Glu Glu Ile Val His Asp           
        675                 680                 685                       

ctt gac acg tgc gaa gtg aca gta gaa ggg gaa gaa ctc aat cat gaa       2112
Leu Asp Thr Cys Glu Val Thr Val Glu Gly Glu Glu Leu Asn His Glu           
    690                 695                 700                           

caa gaa tca ttg gaa gta gat atg gca cga ttg caa caa aag gga atc       2160
Gln Glu Ser Leu Glu Val Asp Met Ala Arg Leu Gln Gln Lys Gly Ile           
705                 710                 715                 720           

gag gtc tcc tca tcc gag ctt ggt atg act ttt act gga gta gat acg       2208
Glu Val Ser Ser Ser Glu Leu Gly Met Thr Phe Thr Gly Val Asp Thr           
                725                 730                 735               

atg gct tcc tat gaa gaa gtg ctg cat ctt ctc aga tac cgc aat tgg       2256
Met Ala Ser Tyr Glu Glu Val Leu His Leu Leu Arg Tyr Arg Asn Trp           
            740                 745                 750                   

cac gcg cgt tct ctg ctg gac aga aaa ttc aaa ctg att tgt agc gaa       2304
His Ala Arg Ser Leu Leu Asp Arg Lys Phe Lys Leu Ile Cys Ser Glu           
        755                 760                 765                       

ctt aac gga cgg tac ata tct aat gag ttc aaa gta gaa gtt aac gtg       2352
Leu Asn Gly Arg Tyr Ile Ser Asn Glu Phe Lys Val Glu Val Asn Val           
    770                 775                 780                           

att cat act gca aat cct atg gag cat gcg gcc gct gcc gcc gct caa       2400
Ile His Thr Ala Asn Pro Met Glu His Ala Ala Ala Ala Ala Ala Gln           
785                 790                 795                 800           

cct caa ttt gtc cat ccc gag cat agg tca ttc gtg gat ctc tct ggt       2448
Pro Gln Phe Val His Pro Glu His Arg Ser Phe Val Asp Leu Ser Gly           
                805                 810                 815               

cat aat ttg gca aat cca cat ccc ttt gct gtg gtt cca tct aca gca       2496
His Asn Leu Ala Asn Pro His Pro Phe Ala Val Val Pro Ser Thr Ala           
            820                 825                 830                   

act gta gtt att gta gta tgt gtg tcc ttt ctc gtc ttt atg atc ata       2544
Thr Val Val Ile Val Val Cys Val Ser Phe Leu Val Phe Met Ile Ile           
        835                 840                 845                       

ttg ggc gtc ttc cgc ata aga gcg gcc cac agg aga aca atg agg gac       2592
Leu Gly Val Phe Arg Ile Arg Ala Ala His Arg Arg Thr Met Arg Asp           
    850                 855                 860                           

caa gat aca gga aaa gaa aat gaa atg gat tgg gat gat agc gca ctc       2640
Gln Asp Thr Gly Lys Glu Asn Glu Met Asp Trp Asp Asp Ser Ala Leu           
865                 870                 875                 880           

aca ata acg gtg aat cca atg gaa acg tac gaa gat caa cat tct agc       2688
Thr Ile Thr Val Asn Pro Met Glu Thr Tyr Glu Asp Gln His Ser Ser           
                885                 890                 895               

gaa gaa gaa gaa gag gaa gag gaa gag gaa gag tca gaa gat gga gaa       2736
Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Ser Glu Asp Gly Glu           
            900                 905                 910                   

gag gaa gac gat att aca tca gct gaa agc gaa tct tca gaa gaa gaa       2784
Glu Glu Asp Asp Ile Thr Ser Ala Glu Ser Glu Ser Ser Glu Glu Glu           
        915                 920                 925                       

gaa ggt gaa caa ggt gat cct caa aat gcc aca cgc caa caa caa ctc       2832
Glu Gly Glu Gln Gly Asp Pro Gln Asn Ala Thr Arg Gln Gln Gln Leu           
    930                 935                 940                           

gaa tgg gac gat tct aca ttg tcc tat                                   2859
Glu Trp Asp Asp Ser Thr Leu Ser Tyr                                       
945                 950                                                   


<210>  70
<211>  953
<212>  PRT
<213>  Homo sapiens

<400>  70

Ala Arg Val Asn Lys His Lys Pro Trp Leu Glu Pro Thr Tyr His Gly 
1               5                   10                  15      


Ile Val Thr Glu Asn Asp Asn Thr Val Leu Leu Asp Pro Pro Leu Ile 
            20                  25                  30          


Ala Leu Asp Lys Asp Ala Pro Leu Arg Phe Ala Glu Ser Phe Glu Val 
        35                  40                  45              


Thr Val Thr Lys Glu Gly Glu Ile Cys Gly Phe Lys Ile His Gly Gln 
    50                  55                  60                  


Asn Val Pro Phe Asp Ala Val Val Val Asp Lys Ser Thr Gly Glu Gly 
65                  70                  75                  80  


Val Ile Arg Ser Lys Glu Lys Leu Asp Cys Glu Leu Gln Lys Asp Tyr 
                85                  90                  95      


Ser Phe Thr Ile Gln Ala Tyr Asp Cys Gly Lys Gly Pro Asp Gly Thr 
            100                 105                 110         


Asn Val Lys Lys Ser His Lys Ala Thr Val His Ile Gln Val Asn Asp 
        115                 120                 125             


Val Asn Glu Tyr Ala Pro Val Phe Lys Glu Lys Ser Tyr Lys Ala Thr 
    130                 135                 140                 


Val Ile Glu Gly Lys Gln Tyr Asp Ser Ile Leu Arg Val Glu Ala Val 
145                 150                 155                 160 


Asp Ala Asp Cys Ser Pro Gln Phe Ser Gln Ile Cys Ser Tyr Glu Ile 
                165                 170                 175     


Ile Thr Pro Asp Val Pro Phe Thr Val Asp Lys Asp Gly Tyr Ile Lys 
            180                 185                 190         


Asn Thr Glu Lys Leu Asn Tyr Gly Lys Glu His Gln Tyr Lys Leu Thr 
        195                 200                 205             


Val Thr Ala Tyr Asp Cys Gly Lys Lys Arg Ala Thr Glu Asp Val Leu 
    210                 215                 220                 


Val Lys Ile Ser Ile Lys Pro Thr Cys Thr Pro Gly Trp Gln Gly Trp 
225                 230                 235                 240 


Asn Asn Arg Ile Glu Tyr Glu Pro Gly Thr Gly Ala Leu Ala Val Phe 
                245                 250                 255     


Pro Asn Ile His Leu Glu Thr Cys Asp Glu Pro Val Ala Ser Val Gln 
            260                 265                 270         


Ala Thr Val Glu Leu Glu Thr Ser His Ile Gly Lys Gly Cys Asp Arg 
        275                 280                 285             


Asp Thr Tyr Ser Glu Lys Ser Leu His Arg Leu Cys Gly Ala Ala Ala 
    290                 295                 300                 


Gly Thr Ala Glu Leu Leu Pro Ser Pro Ser Gly Ser Leu Asn Trp Thr 
305                 310                 315                 320 


Met Gly Leu Pro Thr Asp Asn Gly His Asp Ser Asp Gln Val Phe Glu 
                325                 330                 335     


Phe Asn Gly Thr Gln Ala Val Arg Ile Pro Asp Gly Val Val Ser Val 
            340                 345                 350         


Ser Pro Lys Glu Pro Phe Thr Ile Ser Val Trp Met Arg His Gly Pro 
        355                 360                 365             


Phe Gly Arg Lys Lys Glu Thr Ile Leu Cys Ser Ser Asp Lys Thr Asp 
    370                 375                 380                 


Met Asn Arg His His Tyr Ser Leu Tyr Val His Gly Cys Arg Leu Ile 
385                 390                 395                 400 


Phe Leu Phe Arg Gln Asp Pro Ser Glu Glu Lys Lys Tyr Arg Pro Ala 
                405                 410                 415     


Glu Phe His Trp Lys Leu Asn Gln Val Cys Asp Glu Glu Trp His His 
            420                 425                 430         


Tyr Val Leu Asn Val Glu Phe Pro Ser Val Thr Leu Tyr Val Asp Gly 
        435                 440                 445             


Thr Ser His Glu Pro Phe Ser Val Thr Glu Asp Tyr Pro Leu His Pro 
    450                 455                 460                 


Ser Lys Ile Glu Thr Gln Leu Val Val Gly Ala Cys Trp Gln Glu Phe 
465                 470                 475                 480 


Ser Gly Val Glu Asn Asp Asn Glu Thr Glu Pro Val Thr Val Ala Ser 
                485                 490                 495     


Ala Gly Gly Asp Leu His Met Thr Gln Phe Phe Arg Gly Asn Leu Ala 
            500                 505                 510         


Gly Leu Thr Leu Arg Ser Gly Lys Leu Ala Asp Lys Lys Val Ile Asp 
        515                 520                 525             


Cys Leu Tyr Thr Cys Lys Glu Gly Leu Asp Leu Gln Val Leu Glu Asp 
    530                 535                 540                 


Ser Gly Arg Gly Val Gln Ile Gln Ala His Pro Ser Gln Leu Val Leu 
545                 550                 555                 560 


Thr Leu Glu Gly Glu Asp Leu Gly Glu Leu Asp Lys Ala Met Gln His 
                565                 570                 575     


Ile Ser Tyr Leu Asn Ser Arg Gln Phe Pro Thr Pro Gly Ile Arg Arg 
            580                 585                 590         


Leu Lys Ile Thr Ser Thr Ile Lys Cys Phe Asn Glu Ala Thr Cys Ile 
        595                 600                 605             


Ser Val Pro Pro Val Asp Gly Tyr Val Met Val Leu Gln Pro Glu Glu 
    610                 615                 620                 


Pro Lys Ile Ser Leu Ser Gly Val His His Phe Ala Arg Ala Ala Ser 
625                 630                 635                 640 


Glu Phe Glu Ser Ser Glu Gly Val Phe Leu Phe Pro Glu Leu Arg Ile 
                645                 650                 655     


Ile Ser Thr Ile Thr Arg Glu Val Glu Pro Glu Gly Asp Gly Ala Glu 
            660                 665                 670         


Asp Pro Thr Val Gln Glu Ser Leu Val Ser Glu Glu Ile Val His Asp 
        675                 680                 685             


Leu Asp Thr Cys Glu Val Thr Val Glu Gly Glu Glu Leu Asn His Glu 
    690                 695                 700                 


Gln Glu Ser Leu Glu Val Asp Met Ala Arg Leu Gln Gln Lys Gly Ile 
705                 710                 715                 720 


Glu Val Ser Ser Ser Glu Leu Gly Met Thr Phe Thr Gly Val Asp Thr 
                725                 730                 735     


Met Ala Ser Tyr Glu Glu Val Leu His Leu Leu Arg Tyr Arg Asn Trp 
            740                 745                 750         


His Ala Arg Ser Leu Leu Asp Arg Lys Phe Lys Leu Ile Cys Ser Glu 
        755                 760                 765             


Leu Asn Gly Arg Tyr Ile Ser Asn Glu Phe Lys Val Glu Val Asn Val 
    770                 775                 780                 


Ile His Thr Ala Asn Pro Met Glu His Ala Ala Ala Ala Ala Ala Gln 
785                 790                 795                 800 


Pro Gln Phe Val His Pro Glu His Arg Ser Phe Val Asp Leu Ser Gly 
                805                 810                 815     


His Asn Leu Ala Asn Pro His Pro Phe Ala Val Val Pro Ser Thr Ala 
            820                 825                 830         


Thr Val Val Ile Val Val Cys Val Ser Phe Leu Val Phe Met Ile Ile 
        835                 840                 845             


Leu Gly Val Phe Arg Ile Arg Ala Ala His Arg Arg Thr Met Arg Asp 
    850                 855                 860                 


Gln Asp Thr Gly Lys Glu Asn Glu Met Asp Trp Asp Asp Ser Ala Leu 
865                 870                 875                 880 


Thr Ile Thr Val Asn Pro Met Glu Thr Tyr Glu Asp Gln His Ser Ser 
                885                 890                 895     


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Ser Glu Asp Gly Glu 
            900                 905                 910         


Glu Glu Asp Asp Ile Thr Ser Ala Glu Ser Glu Ser Ser Glu Glu Glu 
        915                 920                 925             


Glu Gly Glu Gln Gly Asp Pro Gln Asn Ala Thr Arg Gln Gln Gln Leu 
    930                 935                 940                 


Glu Trp Asp Asp Ser Thr Leu Ser Tyr 
945                 950             


<210>  71
<211>  1179
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1179)

<400>  71
ttg gaa ctt aat ttg aca gat tca gaa aat gcc act tgc ctt tat gca         48
Leu Glu Leu Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala           
1               5                   10                  15                

aaa tgg cag atg aat ttc aca gta cgc tat gaa act aca aat aaa act         96
Lys Trp Gln Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr           
            20                  25                  30                    

tat aaa act gta acc att tca gac cat ggc act gtg aca tat aat gga        144
Tyr Lys Thr Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly           
        35                  40                  45                        

agc att tgt ggg gat gat cag aat ggt ccc aaa ata gca gtg cag ttc        192
Ser Ile Cys Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe           
    50                  55                  60                            

gga cct ggc ttt tcc tgg att gcg aat ttt acc aag gca gca tct act        240
Gly Pro Gly Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr           
65                  70                  75                  80            

tat tca att gac agc gtc tca ttt tcc tac aac act ggt gat aac aca        288
Tyr Ser Ile Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr           
                85                  90                  95                

aca ttt cct gat gct gaa gat aaa gga att ctt act gtt gat gaa ctt        336
Thr Phe Pro Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu           
            100                 105                 110                   

ttg gcc atc aga att cca ttg aat gac ctt ttt aga tgc aat agt tta        384
Leu Ala Ile Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu           
        115                 120                 125                       

tca act ttg gaa aag aat gat gtt gtc caa cac tac tgg gat gtt ctt        432
Ser Thr Leu Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu           
    130                 135                 140                           

gta caa gct ttt gtc caa aat ggc aca gtg agc aca aat gag ttc ctg        480
Val Gln Ala Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu           
145                 150                 155                 160           

tgt gat aaa gac aaa act tca aca gtg gca ccc acc ata cac acc act        528
Cys Asp Lys Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr           
                165                 170                 175               

gtg cca tct cct act aca aca cct act cca aag gaa aaa cca gaa gct        576
Val Pro Ser Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala           
            180                 185                 190                   

gga acc tat tca gtt aat aat ggc aat gat act tgt ctg ctg gct acc        624
Gly Thr Tyr Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr           
        195                 200                 205                       

atg ggg ctg cag ctg aac atc act cag gat aag gtt gct tca gtt att        672
Met Gly Leu Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile           
    210                 215                 220                           

aac atc aac ccc aat aca act cac tcc aca ggc agc tgc cgt tct cac        720
Asn Ile Asn Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His           
225                 230                 235                 240           

act gct cta ctt aga ctc aat agc agc acc att aag tat cta gac ttt        768
Thr Ala Leu Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe           
                245                 250                 255               

gtc ttt gct gtg aaa aat gaa aac cga ttt tat ctg aag gaa gtg aac        816
Val Phe Ala Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn           
            260                 265                 270                   

atc agc atg tat ttg gtt aat ggc tcc gtt ttc agc att gca aat aac        864
Ile Ser Met Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn           
        275                 280                 285                       

aat ctc agc tac tgg gat gcc ccc ctg gga agt tct tat atg tgc aac        912
Asn Leu Ser Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn           
    290                 295                 300                           

aaa gag cag act gtt tca gtg tct gga gca ttt cag ata aat acc ttt        960
Lys Glu Gln Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe           
305                 310                 315                 320           

gat cta agg gtt cag cct ttc aat gtg aca caa gga aag tat tct aca       1008
Asp Leu Arg Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr           
                325                 330                 335               

gcc caa gag tgt tcg ctg gat gat gac acc att cta atc cca att ata       1056
Ala Gln Glu Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile           
            340                 345                 350                   

gtt ggt gct ggt ctt tca ggc ttg att atc gtt ata gtg att gct agc       1104
Val Gly Ala Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Ser           
        355                 360                 365                       

tcc cac tgg tgt tgt aag aag gag gtt cag gag aca cgg cgc gag cgc       1152
Ser His Trp Cys Cys Lys Lys Glu Val Gln Glu Thr Arg Arg Glu Arg           
    370                 375                 380                           

cgc agg ctc atg tcg atg gag atg gac                                   1179
Arg Arg Leu Met Ser Met Glu Met Asp                                       
385                 390                                                   


<210>  72
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  72

Leu Glu Leu Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala 
1               5                   10                  15      


Lys Trp Gln Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr 
            20                  25                  30          


Tyr Lys Thr Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly 
        35                  40                  45              


Ser Ile Cys Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe 
    50                  55                  60                  


Gly Pro Gly Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr 
65                  70                  75                  80  


Tyr Ser Ile Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr 
                85                  90                  95      


Thr Phe Pro Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu 
            100                 105                 110         


Leu Ala Ile Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu 
        115                 120                 125             


Ser Thr Leu Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu 
    130                 135                 140                 


Val Gln Ala Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu 
145                 150                 155                 160 


Cys Asp Lys Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr 
                165                 170                 175     


Val Pro Ser Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala 
            180                 185                 190         


Gly Thr Tyr Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr 
        195                 200                 205             


Met Gly Leu Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile 
    210                 215                 220                 


Asn Ile Asn Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His 
225                 230                 235                 240 


Thr Ala Leu Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe 
                245                 250                 255     


Val Phe Ala Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn 
            260                 265                 270         


Ile Ser Met Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn 
        275                 280                 285             


Asn Leu Ser Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn 
    290                 295                 300                 


Lys Glu Gln Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe 
305                 310                 315                 320 


Asp Leu Arg Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr 
                325                 330                 335     


Ala Gln Glu Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile 
            340                 345                 350         


Val Gly Ala Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Ser 
        355                 360                 365             


Ser His Trp Cys Cys Lys Lys Glu Val Gln Glu Thr Arg Arg Glu Arg 
    370                 375                 380                 


Arg Arg Leu Met Ser Met Glu Met Asp 
385                 390             


<210>  73
<211>  1212
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1212)

<400>  73
ttg gaa ctt aat ttg aca gat tca gaa aat gcc act tgc ctt tat gca         48
Leu Glu Leu Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala           
1               5                   10                  15                

aaa tgg cag atg aat ttc aca gta cgc tat gaa act aca aat aaa act         96
Lys Trp Gln Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr           
            20                  25                  30                    

tat aaa act gta acc att tca gac cat ggc act gtg aca tat aat gga        144
Tyr Lys Thr Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly           
        35                  40                  45                        

agc att tgt ggg gat gat cag aat ggt ccc aaa ata gca gtg cag ttc        192
Ser Ile Cys Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe           
    50                  55                  60                            

gga cct ggc ttt tcc tgg att gcg aat ttt acc aag gca gca tct act        240
Gly Pro Gly Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr           
65                  70                  75                  80            

tat tca att gac agc gtc tca ttt tcc tac aac act ggt gat aac aca        288
Tyr Ser Ile Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr           
                85                  90                  95                

aca ttt cct gat gct gaa gat aaa gga att ctt act gtt gat gaa ctt        336
Thr Phe Pro Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu           
            100                 105                 110                   

ttg gcc atc aga att cca ttg aat gac ctt ttt aga tgc aat agt tta        384
Leu Ala Ile Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu           
        115                 120                 125                       

tca act ttg gaa aag aat gat gtt gtc caa cac tac tgg gat gtt ctt        432
Ser Thr Leu Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu           
    130                 135                 140                           

gta caa gct ttt gtc caa aat ggc aca gtg agc aca aat gag ttc ctg        480
Val Gln Ala Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu           
145                 150                 155                 160           

tgt gat aaa gac aaa act tca aca gtg gca ccc acc ata cac acc act        528
Cys Asp Lys Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr           
                165                 170                 175               

gtg cca tct cct act aca aca cct act cca aag gaa aaa cca gaa gct        576
Val Pro Ser Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala           
            180                 185                 190                   

gga acc tat tca gtt aat aat ggc aat gat act tgt ctg ctg gct acc        624
Gly Thr Tyr Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr           
        195                 200                 205                       

atg ggg ctg cag ctg aac atc act cag gat aag gtt gct tca gtt att        672
Met Gly Leu Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile           
    210                 215                 220                           

aac atc aac ccc aat aca act cac tcc aca ggc agc tgc cgt tct cac        720
Asn Ile Asn Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His           
225                 230                 235                 240           

act gct cta ctt aga ctc aat agc agc acc att aag tat cta gac ttt        768
Thr Ala Leu Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe           
                245                 250                 255               

gtc ttt gct gtg aaa aat gaa aac cga ttt tat ctg aag gaa gtg aac        816
Val Phe Ala Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn           
            260                 265                 270                   

atc agc atg tat ttg gtt aat ggc tcc gtt ttc agc att gca aat aac        864
Ile Ser Met Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn           
        275                 280                 285                       

aat ctc agc tac tgg gat gcc ccc ctg gga agt tct tat atg tgc aac        912
Asn Leu Ser Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn           
    290                 295                 300                           

aaa gag cag act gtt tca gtg tct gga gca ttt cag ata aat acc ttt        960
Lys Glu Gln Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe           
305                 310                 315                 320           

gat cta agg gtt cag cct ttc aat gtg aca caa gga aag tat tct aca       1008
Asp Leu Arg Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr           
                325                 330                 335               

gcc caa gag tgt tcg ctg gat gat gac acc att cta atc cca att ata       1056
Ala Gln Glu Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile           
            340                 345                 350                   

gtt ggt gct ggt ctt tca ggc ttg att atc gtt ata gtg att gct aag       1104
Val Gly Ala Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Lys           
        355                 360                 365                       

tgc ggc ttc ttc aag cga gcc cgc act cgc gcc ctg tat gaa gct aag       1152
Cys Gly Phe Phe Lys Arg Ala Arg Thr Arg Ala Leu Tyr Glu Ala Lys           
    370                 375                 380                           

agg cag aag gcg gag atg aag agc cag ccg tca gag aca gag agg ctg       1200
Arg Gln Lys Ala Glu Met Lys Ser Gln Pro Ser Glu Thr Glu Arg Leu           
385                 390                 395                 400           

acc gac gac tac                                                       1212
Thr Asp Asp Tyr                                                           
                                                                          


<210>  74
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  74

Leu Glu Leu Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala 
1               5                   10                  15      


Lys Trp Gln Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr 
            20                  25                  30          


Tyr Lys Thr Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly 
        35                  40                  45              


Ser Ile Cys Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe 
    50                  55                  60                  


Gly Pro Gly Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr 
65                  70                  75                  80  


Tyr Ser Ile Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr 
                85                  90                  95      


Thr Phe Pro Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu 
            100                 105                 110         


Leu Ala Ile Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu 
        115                 120                 125             


Ser Thr Leu Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu 
    130                 135                 140                 


Val Gln Ala Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu 
145                 150                 155                 160 


Cys Asp Lys Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr 
                165                 170                 175     


Val Pro Ser Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala 
            180                 185                 190         


Gly Thr Tyr Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr 
        195                 200                 205             


Met Gly Leu Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile 
    210                 215                 220                 


Asn Ile Asn Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His 
225                 230                 235                 240 


Thr Ala Leu Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe 
                245                 250                 255     


Val Phe Ala Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn 
            260                 265                 270         


Ile Ser Met Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn 
        275                 280                 285             


Asn Leu Ser Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn 
    290                 295                 300                 


Lys Glu Gln Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe 
305                 310                 315                 320 


Asp Leu Arg Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr 
                325                 330                 335     


Ala Gln Glu Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile 
            340                 345                 350         


Val Gly Ala Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Lys 
        355                 360                 365             


Cys Gly Phe Phe Lys Arg Ala Arg Thr Arg Ala Leu Tyr Glu Ala Lys 
    370                 375                 380                 


Arg Gln Lys Ala Glu Met Lys Ser Gln Pro Ser Glu Thr Glu Arg Leu 
385                 390                 395                 400 


Thr Asp Asp Tyr 
                


<210>  75
<211>  1248
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1248)

<400>  75
ttg gaa ctt aat ttg aca gat tca gaa aat gcc act tgc ctt tat gca         48
Leu Glu Leu Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala           
1               5                   10                  15                

aaa tgg cag atg aat ttc aca gta cgc tat gaa act aca aat aaa act         96
Lys Trp Gln Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr           
            20                  25                  30                    

tat aaa act gta acc att tca gac cat ggc act gtg aca tat aat gga        144
Tyr Lys Thr Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly           
        35                  40                  45                        

agc att tgt ggg gat gat cag aat ggt ccc aaa ata gca gtg cag ttc        192
Ser Ile Cys Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe           
    50                  55                  60                            

gga cct ggc ttt tcc tgg att gcg aat ttt acc aag gca gca tct act        240
Gly Pro Gly Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr           
65                  70                  75                  80            

tat tca att gac agc gtc tca ttt tcc tac aac act ggt gat aac aca        288
Tyr Ser Ile Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr           
                85                  90                  95                

aca ttt cct gat gct gaa gat aaa gga att ctt act gtt gat gaa ctt        336
Thr Phe Pro Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu           
            100                 105                 110                   

ttg gcc atc aga att cca ttg aat gac ctt ttt aga tgc aat agt tta        384
Leu Ala Ile Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu           
        115                 120                 125                       

tca act ttg gaa aag aat gat gtt gtc caa cac tac tgg gat gtt ctt        432
Ser Thr Leu Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu           
    130                 135                 140                           

gta caa gct ttt gtc caa aat ggc aca gtg agc aca aat gag ttc ctg        480
Val Gln Ala Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu           
145                 150                 155                 160           

tgt gat aaa gac aaa act tca aca gtg gca ccc acc ata cac acc act        528
Cys Asp Lys Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr           
                165                 170                 175               

gtg cca tct cct act aca aca cct act cca aag gaa aaa cca gaa gct        576
Val Pro Ser Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala           
            180                 185                 190                   

gga acc tat tca gtt aat aat ggc aat gat act tgt ctg ctg gct acc        624
Gly Thr Tyr Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr           
        195                 200                 205                       

atg ggg ctg cag ctg aac atc act cag gat aag gtt gct tca gtt att        672
Met Gly Leu Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile           
    210                 215                 220                           

aac atc aac ccc aat aca act cac tcc aca ggc agc tgc cgt tct cac        720
Asn Ile Asn Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His           
225                 230                 235                 240           

act gct cta ctt aga ctc aat agc agc acc att aag tat cta gac ttt        768
Thr Ala Leu Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe           
                245                 250                 255               

gtc ttt gct gtg aaa aat gaa aac cga ttt tat ctg aag gaa gtg aac        816
Val Phe Ala Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn           
            260                 265                 270                   

atc agc atg tat ttg gtt aat ggc tcc gtt ttc agc att gca aat aac        864
Ile Ser Met Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn           
        275                 280                 285                       

aat ctc agc tac tgg gat gcc ccc ctg gga agt tct tat atg tgc aac        912
Asn Leu Ser Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn           
    290                 295                 300                           

aaa gag cag act gtt tca gtg tct gga gca ttt cag ata aat acc ttt        960
Lys Glu Gln Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe           
305                 310                 315                 320           

gat cta agg gtt cag cct ttc aat gtg aca caa gga aag tat tct aca       1008
Asp Leu Arg Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr           
                325                 330                 335               

gcc caa gag tgt tcg ctg gat gat gac acc att cta atc cca att ata       1056
Ala Gln Glu Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile           
            340                 345                 350                   

gtt ggt gct ggt ctt tca ggc ttg att atc gtt ata gtg att gct gtg       1104
Val Gly Ala Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Val           
        355                 360                 365                       

atg cag aga ctc ttt ccc cgc atc cct cac atg aaa gac ccc atc ggt       1152
Met Gln Arg Leu Phe Pro Arg Ile Pro His Met Lys Asp Pro Ile Gly           
    370                 375                 380                           

gac agc ttc caa aac gac aag ctg gtg gtc tgg gag gcg ggc aaa gcc       1200
Asp Ser Phe Gln Asn Asp Lys Leu Val Val Trp Glu Ala Gly Lys Ala           
385                 390                 395                 400           

ggc ctg gag gag tgt ctg gtg act gaa gta cag gtc gtg cag aaa act       1248
Gly Leu Glu Glu Cys Leu Val Thr Glu Val Gln Val Val Gln Lys Thr           
                405                 410                 415               


<210>  76
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  76

Leu Glu Leu Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala 
1               5                   10                  15      


Lys Trp Gln Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr 
            20                  25                  30          


Tyr Lys Thr Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly 
        35                  40                  45              


Ser Ile Cys Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe 
    50                  55                  60                  


Gly Pro Gly Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr 
65                  70                  75                  80  


Tyr Ser Ile Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr 
                85                  90                  95      


Thr Phe Pro Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu 
            100                 105                 110         


Leu Ala Ile Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu 
        115                 120                 125             


Ser Thr Leu Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu 
    130                 135                 140                 


Val Gln Ala Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu 
145                 150                 155                 160 


Cys Asp Lys Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr 
                165                 170                 175     


Val Pro Ser Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala 
            180                 185                 190         


Gly Thr Tyr Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr 
        195                 200                 205             


Met Gly Leu Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile 
    210                 215                 220                 


Asn Ile Asn Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His 
225                 230                 235                 240 


Thr Ala Leu Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe 
                245                 250                 255     


Val Phe Ala Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn 
            260                 265                 270         


Ile Ser Met Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn 
        275                 280                 285             


Asn Leu Ser Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn 
    290                 295                 300                 


Lys Glu Gln Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe 
305                 310                 315                 320 


Asp Leu Arg Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr 
                325                 330                 335     


Ala Gln Glu Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile 
            340                 345                 350         


Val Gly Ala Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Val 
        355                 360                 365             


Met Gln Arg Leu Phe Pro Arg Ile Pro His Met Lys Asp Pro Ile Gly 
    370                 375                 380                 


Asp Ser Phe Gln Asn Asp Lys Leu Val Val Trp Glu Ala Gly Lys Ala 
385                 390                 395                 400 


Gly Leu Glu Glu Cys Leu Val Thr Glu Val Gln Val Val Gln Lys Thr 
                405                 410                 415     


<210>  77
<211>  1308
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1308)

<400>  77
ttg gaa ctt aat ttg aca gat tca gaa aat gcc act tgc ctt tat gca         48
Leu Glu Leu Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala           
1               5                   10                  15                

aaa tgg cag atg aat ttc aca gta cgc tat gaa act aca aat aaa act         96
Lys Trp Gln Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr           
            20                  25                  30                    

tat aaa act gta acc att tca gac cat ggc act gtg aca tat aat gga        144
Tyr Lys Thr Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly           
        35                  40                  45                        

agc att tgt ggg gat gat cag aat ggt ccc aaa ata gca gtg cag ttc        192
Ser Ile Cys Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe           
    50                  55                  60                            

gga cct ggc ttt tcc tgg att gcg aat ttt acc aag gca gca tct act        240
Gly Pro Gly Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr           
65                  70                  75                  80            

tat tca att gac agc gtc tca ttt tcc tac aac act ggt gat aac aca        288
Tyr Ser Ile Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr           
                85                  90                  95                

aca ttt cct gat gct gaa gat aaa gga att ctt act gtt gat gaa ctt        336
Thr Phe Pro Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu           
            100                 105                 110                   

ttg gcc atc aga att cca ttg aat gac ctt ttt aga tgc aat agt tta        384
Leu Ala Ile Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu           
        115                 120                 125                       

tca act ttg gaa aag aat gat gtt gtc caa cac tac tgg gat gtt ctt        432
Ser Thr Leu Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu           
    130                 135                 140                           

gta caa gct ttt gtc caa aat ggc aca gtg agc aca aat gag ttc ctg        480
Val Gln Ala Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu           
145                 150                 155                 160           

tgt gat aaa gac aaa act tca aca gtg gca ccc acc ata cac acc act        528
Cys Asp Lys Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr           
                165                 170                 175               

gtg cca tct cct act aca aca cct act cca aag gaa aaa cca gaa gct        576
Val Pro Ser Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala           
            180                 185                 190                   

gga acc tat tca gtt aat aat ggc aat gat act tgt ctg ctg gct acc        624
Gly Thr Tyr Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr           
        195                 200                 205                       

atg ggg ctg cag ctg aac atc act cag gat aag gtt gct tca gtt att        672
Met Gly Leu Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile           
    210                 215                 220                           

aac atc aac ccc aat aca act cac tcc aca ggc agc tgc cgt tct cac        720
Asn Ile Asn Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His           
225                 230                 235                 240           

act gct cta ctt aga ctc aat agc agc acc att aag tat cta gac ttt        768
Thr Ala Leu Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe           
                245                 250                 255               

gtc ttt gct gtg aaa aat gaa aac cga ttt tat ctg aag gaa gtg aac        816
Val Phe Ala Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn           
            260                 265                 270                   

atc agc atg tat ttg gtt aat ggc tcc gtt ttc agc att gca aat aac        864
Ile Ser Met Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn           
        275                 280                 285                       

aat ctc agc tac tgg gat gcc ccc ctg gga agt tct tat atg tgc aac        912
Asn Leu Ser Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn           
    290                 295                 300                           

aaa gag cag act gtt tca gtg tct gga gca ttt cag ata aat acc ttt        960
Lys Glu Gln Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe           
305                 310                 315                 320           

gat cta agg gtt cag cct ttc aat gtg aca caa gga aag tat tct aca       1008
Asp Leu Arg Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr           
                325                 330                 335               

gcc caa gag tgt tcg ctg gat gat gac acc att cta atc cca att ata       1056
Ala Gln Glu Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile           
            340                 345                 350                   

gtt ggt gct ggt ctt tca ggc ttg att atc gtt ata gtg att gct cgc       1104
Val Gly Ala Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Arg           
        355                 360                 365                       

ctc tcc cgc aag ggc cac atg tac ccc gtg cgt aat tac tcc ccc acc       1152
Leu Ser Arg Lys Gly His Met Tyr Pro Val Arg Asn Tyr Ser Pro Thr           
    370                 375                 380                           

gag atg gtc tgc atc tca tcc ctg ttg cct gat ggg ggt gag ggg ccc       1200
Glu Met Val Cys Ile Ser Ser Leu Leu Pro Asp Gly Gly Glu Gly Pro           
385                 390                 395                 400           

tct gcc aca gcc aat ggg ggc ctg tcc aag gcc aag agc ccg ggc ctg       1248
Ser Ala Thr Ala Asn Gly Gly Leu Ser Lys Ala Lys Ser Pro Gly Leu           
                405                 410                 415               

acg cca gag ccc agg gag gac cgt gag ggg gat gac ctc acc ctg cac       1296
Thr Pro Glu Pro Arg Glu Asp Arg Glu Gly Asp Asp Leu Thr Leu His           
            420                 425                 430                   

agc ttc ctc cct                                                       1308
Ser Phe Leu Pro                                                           
        435                                                               


<210>  78
<211>  436
<212>  PRT
<213>  Homo sapiens

<400>  78

Leu Glu Leu Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala 
1               5                   10                  15      


Lys Trp Gln Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr 
            20                  25                  30          


Tyr Lys Thr Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly 
        35                  40                  45              


Ser Ile Cys Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe 
    50                  55                  60                  


Gly Pro Gly Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr 
65                  70                  75                  80  


Tyr Ser Ile Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr 
                85                  90                  95      


Thr Phe Pro Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu 
            100                 105                 110         


Leu Ala Ile Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu 
        115                 120                 125             


Ser Thr Leu Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu 
    130                 135                 140                 


Val Gln Ala Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu 
145                 150                 155                 160 


Cys Asp Lys Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr 
                165                 170                 175     


Val Pro Ser Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala 
            180                 185                 190         


Gly Thr Tyr Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr 
        195                 200                 205             


Met Gly Leu Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile 
    210                 215                 220                 


Asn Ile Asn Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His 
225                 230                 235                 240 


Thr Ala Leu Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe 
                245                 250                 255     


Val Phe Ala Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn 
            260                 265                 270         


Ile Ser Met Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn 
        275                 280                 285             


Asn Leu Ser Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn 
    290                 295                 300                 


Lys Glu Gln Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe 
305                 310                 315                 320 


Asp Leu Arg Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr 
                325                 330                 335     


Ala Gln Glu Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile 
            340                 345                 350         


Val Gly Ala Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Arg 
        355                 360                 365             


Leu Ser Arg Lys Gly His Met Tyr Pro Val Arg Asn Tyr Ser Pro Thr 
    370                 375                 380                 


Glu Met Val Cys Ile Ser Ser Leu Leu Pro Asp Gly Gly Glu Gly Pro 
385                 390                 395                 400 


Ser Ala Thr Ala Asn Gly Gly Leu Ser Lys Ala Lys Ser Pro Gly Leu 
                405                 410                 415     


Thr Pro Glu Pro Arg Glu Asp Arg Glu Gly Asp Asp Leu Thr Leu His 
            420                 425                 430         


Ser Phe Leu Pro 
        435     


<210>  79
<211>  1239
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1239)

<400>  79
ttg gaa ctt aat ttg aca gat tca gaa aat gcc act tgc ctt tat gca         48
Leu Glu Leu Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala           
1               5                   10                  15                

aaa tgg cag atg aat ttc aca gta cgc tat gaa act aca aat aaa act         96
Lys Trp Gln Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr           
            20                  25                  30                    

tat aaa act gta acc att tca gac cat ggc act gtg aca tat aat gga        144
Tyr Lys Thr Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly           
        35                  40                  45                        

agc att tgt ggg gat gat cag aat ggt ccc aaa ata gca gtg cag ttc        192
Ser Ile Cys Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe           
    50                  55                  60                            

gga cct ggc ttt tcc tgg att gcg aat ttt acc aag gca gca tct act        240
Gly Pro Gly Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr           
65                  70                  75                  80            

tat tca att gac agc gtc tca ttt tcc tac aac act ggt gat aac aca        288
Tyr Ser Ile Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr           
                85                  90                  95                

aca ttt cct gat gct gaa gat aaa gga att ctt act gtt gat gaa ctt        336
Thr Phe Pro Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu           
            100                 105                 110                   

ttg gcc atc aga att cca ttg aat gac ctt ttt aga tgc aat agt tta        384
Leu Ala Ile Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu           
        115                 120                 125                       

tca act ttg gaa aag aat gat gtt gtc caa cac tac tgg gat gtt ctt        432
Ser Thr Leu Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu           
    130                 135                 140                           

gta caa gct ttt gtc caa aat ggc aca gtg agc aca aat gag ttc ctg        480
Val Gln Ala Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu           
145                 150                 155                 160           

tgt gat aaa gac aaa act tca aca gtg gca ccc acc ata cac acc act        528
Cys Asp Lys Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr           
                165                 170                 175               

gtg cca tct cct act aca aca cct act cca aag gaa aaa cca gaa gct        576
Val Pro Ser Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala           
            180                 185                 190                   

gga acc tat tca gtt aat aat ggc aat gat act tgt ctg ctg gct acc        624
Gly Thr Tyr Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr           
        195                 200                 205                       

atg ggg ctg cag ctg aac atc act cag gat aag gtt gct tca gtt att        672
Met Gly Leu Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile           
    210                 215                 220                           

aac atc aac ccc aat aca act cac tcc aca ggc agc tgc cgt tct cac        720
Asn Ile Asn Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His           
225                 230                 235                 240           

act gct cta ctt aga ctc aat agc agc acc att aag tat cta gac ttt        768
Thr Ala Leu Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe           
                245                 250                 255               

gtc ttt gct gtg aaa aat gaa aac cga ttt tat ctg aag gaa gtg aac        816
Val Phe Ala Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn           
            260                 265                 270                   

atc agc atg tat ttg gtt aat ggc tcc gtt ttc agc att gca aat aac        864
Ile Ser Met Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn           
        275                 280                 285                       

aat ctc agc tac tgg gat gcc ccc ctg gga agt tct tat atg tgc aac        912
Asn Leu Ser Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn           
    290                 295                 300                           

aaa gag cag act gtt tca gtg tct gga gca ttt cag ata aat acc ttt        960
Lys Glu Gln Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe           
305                 310                 315                 320           

gat cta agg gtt cag cct ttc aat gtg aca caa gga aag tat tct aca       1008
Asp Leu Arg Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr           
                325                 330                 335               

gcc caa gag tgt tcg ctg gat gat gac acc att cta atc cca att ata       1056
Ala Gln Glu Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile           
            340                 345                 350                   

gtt ggt gct ggt ctt tca ggc ttg att atc gtt ata gtg att gct ctt       1104
Val Gly Ala Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Leu           
        355                 360                 365                       

tta atg ata att cat gac aga agg gag ttt gct aaa ttt gaa aag gag       1152
Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys Glu           
    370                 375                 380                           

aaa atg aat gcc aaa tgg gac acg ggt gaa aat cct att tat aag agt       1200
Lys Met Asn Ala Lys Trp Asp Thr Gly Glu Asn Pro Ile Tyr Lys Ser           
385                 390                 395                 400           

gcc gta aca act gtg gtc aat ccg aag tat gag gga aaa                   1239
Ala Val Thr Thr Val Val Asn Pro Lys Tyr Glu Gly Lys                       
                405                 410                                   


<210>  80
<211>  413
<212>  PRT
<213>  Homo sapiens

<400>  80

Leu Glu Leu Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala 
1               5                   10                  15      


Lys Trp Gln Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr 
            20                  25                  30          


Tyr Lys Thr Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly 
        35                  40                  45              


Ser Ile Cys Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe 
    50                  55                  60                  


Gly Pro Gly Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr 
65                  70                  75                  80  


Tyr Ser Ile Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr 
                85                  90                  95      


Thr Phe Pro Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu 
            100                 105                 110         


Leu Ala Ile Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu 
        115                 120                 125             


Ser Thr Leu Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu 
    130                 135                 140                 


Val Gln Ala Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu 
145                 150                 155                 160 


Cys Asp Lys Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr 
                165                 170                 175     


Val Pro Ser Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala 
            180                 185                 190         


Gly Thr Tyr Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr 
        195                 200                 205             


Met Gly Leu Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile 
    210                 215                 220                 


Asn Ile Asn Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His 
225                 230                 235                 240 


Thr Ala Leu Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe 
                245                 250                 255     


Val Phe Ala Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn 
            260                 265                 270         


Ile Ser Met Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn 
        275                 280                 285             


Asn Leu Ser Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn 
    290                 295                 300                 


Lys Glu Gln Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe 
305                 310                 315                 320 


Asp Leu Arg Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr 
                325                 330                 335     


Ala Gln Glu Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile 
            340                 345                 350         


Val Gly Ala Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Leu 
        355                 360                 365             


Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys Glu 
    370                 375                 380                 


Lys Met Asn Ala Lys Trp Asp Thr Gly Glu Asn Pro Ile Tyr Lys Ser 
385                 390                 395                 400 


Ala Val Thr Thr Val Val Asn Pro Lys Tyr Glu Gly Lys 
                405                 410             


<210>  81
<211>  1404
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1404)

<400>  81
ttg gaa ctt aat ttg aca gat tca gaa aat gcc act tgc ctt tat gca         48
Leu Glu Leu Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala           
1               5                   10                  15                

aaa tgg cag atg aat ttc aca gta cgc tat gaa act aca aat aaa act         96
Lys Trp Gln Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr           
            20                  25                  30                    

tat aaa act gta acc att tca gac cat ggc act gtg aca tat aat gga        144
Tyr Lys Thr Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly           
        35                  40                  45                        

agc att tgt ggg gat gat cag aat ggt ccc aaa ata gca gtg cag ttc        192
Ser Ile Cys Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe           
    50                  55                  60                            

gga cct ggc ttt tcc tgg att gcg aat ttt acc aag gca gca tct act        240
Gly Pro Gly Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr           
65                  70                  75                  80            

tat tca att gac agc gtc tca ttt tcc tac aac act ggt gat aac aca        288
Tyr Ser Ile Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr           
                85                  90                  95                

aca ttt cct gat gct gaa gat aaa gga att ctt act gtt gat gaa ctt        336
Thr Phe Pro Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu           
            100                 105                 110                   

ttg gcc atc aga att cca ttg aat gac ctt ttt aga tgc aat agt tta        384
Leu Ala Ile Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu           
        115                 120                 125                       

tca act ttg gaa aag aat gat gtt gtc caa cac tac tgg gat gtt ctt        432
Ser Thr Leu Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu           
    130                 135                 140                           

gta caa gct ttt gtc caa aat ggc aca gtg agc aca aat gag ttc ctg        480
Val Gln Ala Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu           
145                 150                 155                 160           

tgt gat aaa gac aaa act tca aca gtg gca ccc acc ata cac acc act        528
Cys Asp Lys Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr           
                165                 170                 175               

gtg cca tct cct act aca aca cct act cca aag gaa aaa cca gaa gct        576
Val Pro Ser Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala           
            180                 185                 190                   

gga acc tat tca gtt aat aat ggc aat gat act tgt ctg ctg gct acc        624
Gly Thr Tyr Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr           
        195                 200                 205                       

atg ggg ctg cag ctg aac atc act cag gat aag gtt gct tca gtt att        672
Met Gly Leu Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile           
    210                 215                 220                           

aac atc aac ccc aat aca act cac tcc aca ggc agc tgc cgt tct cac        720
Asn Ile Asn Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His           
225                 230                 235                 240           

act gct cta ctt aga ctc aat agc agc acc att aag tat cta gac ttt        768
Thr Ala Leu Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe           
                245                 250                 255               

gtc ttt gct gtg aaa aat gaa aac cga ttt tat ctg aag gaa gtg aac        816
Val Phe Ala Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn           
            260                 265                 270                   

atc agc atg tat ttg gtt aat ggc tcc gtt ttc agc att gca aat aac        864
Ile Ser Met Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn           
        275                 280                 285                       

aat ctc agc tac tgg gat gcc ccc ctg gga agt tct tat atg tgc aac        912
Asn Leu Ser Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn           
    290                 295                 300                           

aaa gag cag act gtt tca gtg tct gga gca ttt cag ata aat acc ttt        960
Lys Glu Gln Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe           
305                 310                 315                 320           

gat cta agg gtt cag cct ttc aat gtg aca caa gga aag tat tct aca       1008
Asp Leu Arg Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr           
                325                 330                 335               

gcc caa gag tgt tcg ctg gat gat gac acc att cta atc cca att ata       1056
Ala Gln Glu Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile           
            340                 345                 350                   

gtt ggt gct ggt ctt tca ggc ttg att atc gtt ata gtg att gct cgg       1104
Val Gly Ala Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Arg           
        355                 360                 365                       

atc cgg gcc gca cat cgg cgg acc atg cgg gat cag gac acc ggg aag       1152
Ile Arg Ala Ala His Arg Arg Thr Met Arg Asp Gln Asp Thr Gly Lys           
    370                 375                 380                           

gag aac gag atg gac tgg gac gac tct gcc ctg acc atc acc gtc aac       1200
Glu Asn Glu Met Asp Trp Asp Asp Ser Ala Leu Thr Ile Thr Val Asn           
385                 390                 395                 400           

ccc atg gag acc tat gag gac cag cac agc agt gag gag gag gag gaa       1248
Pro Met Glu Thr Tyr Glu Asp Gln His Ser Ser Glu Glu Glu Glu Glu           
                405                 410                 415               

gag gaa gag gaa gag gaa agc gag gac ggc gaa gaa gag gat gac atc       1296
Glu Glu Glu Glu Glu Glu Ser Glu Asp Gly Glu Glu Glu Asp Asp Ile           
            420                 425                 430                   

acc agc gcc gag tcg gag agc agc gag gag gag gag ggg gag cag ggc       1344
Thr Ser Ala Glu Ser Glu Ser Ser Glu Glu Glu Glu Gly Glu Gln Gly           
        435                 440                 445                       

gac ccc cag aac gca acc cgg cag cag cag ctg gag tgg gat gac tcc       1392
Asp Pro Gln Asn Ala Thr Arg Gln Gln Gln Leu Glu Trp Asp Asp Ser           
    450                 455                 460                           

acc ctc agc tac                                                       1404
Thr Leu Ser Tyr                                                           
465                                                                       


<210>  82
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  82

Leu Glu Leu Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala 
1               5                   10                  15      


Lys Trp Gln Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr 
            20                  25                  30          


Tyr Lys Thr Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly 
        35                  40                  45              


Ser Ile Cys Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe 
    50                  55                  60                  


Gly Pro Gly Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr 
65                  70                  75                  80  


Tyr Ser Ile Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr 
                85                  90                  95      


Thr Phe Pro Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu 
            100                 105                 110         


Leu Ala Ile Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu 
        115                 120                 125             


Ser Thr Leu Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu 
    130                 135                 140                 


Val Gln Ala Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu 
145                 150                 155                 160 


Cys Asp Lys Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr 
                165                 170                 175     


Val Pro Ser Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala 
            180                 185                 190         


Gly Thr Tyr Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr 
        195                 200                 205             


Met Gly Leu Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile 
    210                 215                 220                 


Asn Ile Asn Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His 
225                 230                 235                 240 


Thr Ala Leu Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe 
                245                 250                 255     


Val Phe Ala Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn 
            260                 265                 270         


Ile Ser Met Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn 
        275                 280                 285             


Asn Leu Ser Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn 
    290                 295                 300                 


Lys Glu Gln Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe 
305                 310                 315                 320 


Asp Leu Arg Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr 
                325                 330                 335     


Ala Gln Glu Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile 
            340                 345                 350         


Val Gly Ala Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Arg 
        355                 360                 365             


Ile Arg Ala Ala His Arg Arg Thr Met Arg Asp Gln Asp Thr Gly Lys 
    370                 375                 380                 


Glu Asn Glu Met Asp Trp Asp Asp Ser Ala Leu Thr Ile Thr Val Asn 
385                 390                 395                 400 


Pro Met Glu Thr Tyr Glu Asp Gln His Ser Ser Glu Glu Glu Glu Glu 
                405                 410                 415     


Glu Glu Glu Glu Glu Glu Ser Glu Asp Gly Glu Glu Glu Asp Asp Ile 
            420                 425                 430         


Thr Ser Ala Glu Ser Glu Ser Ser Glu Glu Glu Glu Gly Glu Gln Gly 
        435                 440                 445             


Asp Pro Gln Asn Ala Thr Arg Gln Gln Gln Leu Glu Trp Asp Asp Ser 
    450                 455                 460                 


Thr Leu Ser Tyr 
465             


<210>  83
<211>  1113
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1113)

<400>  83
ttg gaa ctt aat ttg aca gat tca gaa aat gcc act tgc ctt tat gca         48
Leu Glu Leu Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala           
1               5                   10                  15                

aaa tgg cag atg aat ttc aca gta cgc tat gaa act aca aat aaa act         96
Lys Trp Gln Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr           
            20                  25                  30                    

tat aaa act gta acc att tca gac cat ggc act gtg aca tat aat gga        144
Tyr Lys Thr Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly           
        35                  40                  45                        

agc att tgt ggg gat gat cag aat ggt ccc aaa ata gca gtg cag ttc        192
Ser Ile Cys Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe           
    50                  55                  60                            

gga cct ggc ttt tcc tgg att gcg aat ttt acc aag gca gca tct act        240
Gly Pro Gly Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr           
65                  70                  75                  80            

tat tca att gac agc gtc tca ttt tcc tac aac act ggt gat aac aca        288
Tyr Ser Ile Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr           
                85                  90                  95                

aca ttt cct gat gct gaa gat aaa gga att ctt act gtt gat gaa ctt        336
Thr Phe Pro Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu           
            100                 105                 110                   

ttg gcc atc aga att cca ttg aat gac ctt ttt aga tgc aat agt tta        384
Leu Ala Ile Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu           
        115                 120                 125                       

tca act ttg gaa aag aat gat gtt gtc caa cac tac tgg gat gtt ctt        432
Ser Thr Leu Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu           
    130                 135                 140                           

gta caa gct ttt gtc caa aat ggc aca gtg agc aca aat gag ttc ctg        480
Val Gln Ala Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu           
145                 150                 155                 160           

tgt gat aaa gac aaa act tca aca gtg gca ccc acc ata cac acc act        528
Cys Asp Lys Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr           
                165                 170                 175               

gtg cca tct cct act aca aca cct act cca aag gaa aaa cca gaa gct        576
Val Pro Ser Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala           
            180                 185                 190                   

gga acc tat tca gtt aat aat ggc aat gat act tgt ctg ctg gct acc        624
Gly Thr Tyr Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr           
        195                 200                 205                       

atg ggg ctg cag ctg aac atc act cag gat aag gtt gct tca gtt att        672
Met Gly Leu Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile           
    210                 215                 220                           

aac atc aac ccc aat aca act cac tcc aca ggc agc tgc cgt tct cac        720
Asn Ile Asn Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His           
225                 230                 235                 240           

act gct cta ctt aga ctc aat agc agc acc att aag tat cta gac ttt        768
Thr Ala Leu Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe           
                245                 250                 255               

gtc ttt gct gtg aaa aat gaa aac cga ttt tat ctg aag gaa gtg aac        816
Val Phe Ala Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn           
            260                 265                 270                   

atc agc atg tat ttg gtt aat ggc tcc gtt ttc agc att gca aat aac        864
Ile Ser Met Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn           
        275                 280                 285                       

aat ctc agc tac tgg gat gcc ccc ctg gga agt tct tat atg tgc aac        912
Asn Leu Ser Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn           
    290                 295                 300                           

aaa gag cag act gtt tca gtg tct gga gca ttt cag ata aat acc ttt        960
Lys Glu Gln Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe           
305                 310                 315                 320           

gat cta agg gtt cag cct ttc aat gtg aca caa gga aag tat tct aca       1008
Asp Leu Arg Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr           
                325                 330                 335               

gcc caa gag tgt tcg ctg gat gat gac acc att cta atc cca att ata       1056
Ala Gln Glu Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile           
            340                 345                 350                   

gtt ggt gct ggt ctt tca ggc ttg att atc gtt ata gtg att gct aag       1104
Val Gly Ala Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Lys           
        355                 360                 365                       

aag cca cgt                                                           1113
Lys Pro Arg                                                               
    370                                                                   


<210>  84
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  84

Leu Glu Leu Asn Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala 
1               5                   10                  15      


Lys Trp Gln Met Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr 
            20                  25                  30          


Tyr Lys Thr Val Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly 
        35                  40                  45              


Ser Ile Cys Gly Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe 
    50                  55                  60                  


Gly Pro Gly Phe Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr 
65                  70                  75                  80  


Tyr Ser Ile Asp Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr 
                85                  90                  95      


Thr Phe Pro Asp Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu 
            100                 105                 110         


Leu Ala Ile Arg Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu 
        115                 120                 125             


Ser Thr Leu Glu Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu 
    130                 135                 140                 


Val Gln Ala Phe Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu 
145                 150                 155                 160 


Cys Asp Lys Asp Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr 
                165                 170                 175     


Val Pro Ser Pro Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala 
            180                 185                 190         


Gly Thr Tyr Ser Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr 
        195                 200                 205             


Met Gly Leu Gln Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile 
    210                 215                 220                 


Asn Ile Asn Pro Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His 
225                 230                 235                 240 


Thr Ala Leu Leu Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe 
                245                 250                 255     


Val Phe Ala Val Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn 
            260                 265                 270         


Ile Ser Met Tyr Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn 
        275                 280                 285             


Asn Leu Ser Tyr Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn 
    290                 295                 300                 


Lys Glu Gln Thr Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe 
305                 310                 315                 320 


Asp Leu Arg Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr 
                325                 330                 335     


Ala Gln Glu Cys Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile 
            340                 345                 350         


Val Gly Ala Gly Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Lys 
        355                 360                 365             


Lys Pro Arg 
    370     


