                         SEQUENCE LISTING

<110>  Svenska Vaccinfabriken Produktion AB
 
<120>  COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING HEPATITIS B 
       AND D

<130>  SVF.005WO

<150>  US 62/966970
<151>  2020-01-28

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HDAg genotype 1 A DNA sequence

<400>  1
agccgcagcg aaagcaaaaa aaaccgcggc ggccgcgaag aaattctgga acagtgggtg       60

ggcgcgcgca aaaaactgga agaactggaa cgcgatctgc gcaaaattaa aaaaaaaatt      120

aaaaaactgg aagaagaaaa cccgtggctg ggcaacatta aaggcattct gggcaaaaaa      180

gatcgcgaag gcgaaggcgc gccgccggcg aaacgcgcgc gcgcggatca gatggaagtg      240

gatagcggcc cgcgcaaacg cccgtttcgc ggcgaattta ccgataaaga acgccgcgat      300

catcgccgcc gcaaagcgct ggaaaacaaa cgcaaacagc tgagcagcgg cggcaaaagc      360

ctgagcaaag aagaagaaga agaactgcgc aaactgaccg aagaagatga acgccgcgaa      420

cgccgcgtgg cgggcccgcg cgtgggcggc gtgaacccgc tggaaggcgg cacccgcggc      480

gcgccgggcg gcggctttgt gccgagcatg cagggcgtgc cggaaagccc gtttgcgcgc      540

accggcgaag gcctggatgt gcgcggcaac cagggctttc cgtgggatat tctgtttccg      600

gcggatccgc cgtttagccc gcagagctgc cgcccgcag                             639


<210>  2
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HDAg genotype 1 B DNA sequence

<400>  2
agccgcagcg aaagcaaaaa aaaccgcggc ggccgcgaag aagtgctgga acagtgggtg       60

aacggccgca aaaaactgga agaactggaa cgcgaactgc gccgcgcgcg caaaaaaatt      120

aaaaaactgg aagatgataa cccgtggctg ggcaacgtga aaggcattct gggcaaaaaa      180

gataaagatg gcgaaggcgc gccgccggcg aaacgcgcgc gcaccgatca gatggaaatt      240

gatagcggcc cgcgcaaacg cccgctgcgc ggcggcttta ccgatcgcga acgccaggat      300

catcgccgcc gcaaagcgct gaaaaacaaa aaaaaacagc tgagcgcggg cggcaaaagc      360

ctgagcaaag aagaagaaga agaactgaaa cgcctgaccc gcgaagatga agaacgcaaa      420

aaagaagaac atggcccgag ccgcctgggc gtgaacccga gcgaaggcgg cccgcgcggc      480

gcgccgggcg gcggctttgt gccgagcatg cagggcattc cggaaagccg ctttacccgc      540

accggcgaag gcctggatgt gcgcggcagc cgcggctttc cgcaggatat tctgtttccg      600

agcgatccgc cgtttagccc gcagagctgc cgcccgcag                             639


<210>  3
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HDAg genotype 2 A DNA sequence

<400>  3
agccagagcg aaacccgccg cggccgccgc ggcacccgcg aagaaaccct ggaaaaatgg       60

attaccgcgc gcaaaaaagc ggaagaactg gaaaaagatc tgcgcaaaac ccgcaaaacc      120

attaaaaaac tggaagaaga aaacccgtgg ctgggcaaca ttgtgggcat tattcgcaaa      180

ggcaaagatg gcgaaggcgc gccgccggcg aaacgcccgc gcaccgatca gatggaagtg      240

gatagcggcc cgggcaaacg cccgcataaa agcggcttta ccgataaaga acgcgaagat      300

catcgccgcc gcaaagcgct ggaaaacaaa aaaaaacagc tgagcgcggg cggcaaaatt      360

ctgagcaaag aagaagaaga agaactgcgc cgcctgaccg atgaagatga agaacgcaaa      420

cgccgcgtgg cgggcccgcg cgtgggcgat gtgaacccga gccgcggcgg cccgcgcggc      480

gcgccgggcg gcggctttgt gccgcagatg gcgggcgtgc cggaaagccc gtttagccgc      540

accggcgaag gcctggatat tcgcggcacc cagggctttc cgtgggtgag cccgagcccg      600

ccgcagcagc gcctgccgct gctggaatgc accccgcag                             639


<210>  4
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HDAg genotype 2 B DNA sequence

<400>  4
agccagagcg aaagcaaaaa aaaccgccgc ggcggccgcg aagatattct ggaaaaatgg       60

attaccaccc gccgcaaagc ggaagaactg gaaaaagatc tgcgcaaagc gcgcaaaacc      120

attaaaaaac tggaagatga aaacccgtgg ctgggcaaca ttattggcat tattcgcaaa      180

ggcaaagatg gcgaaggcgc gccgccggcg aaacgcccgc gcaccgatca gatggaaatt      240

gatagcggca ccggcaaacg cccgcataaa agcggcttta ccgataaaga acgcgaagat      300

catcgccgcc gcaaagcgct ggaaaacaaa aaaaaacagc tgagcagcgg cggcaaaaac      360

ctgagccgcg aagaagaaga agaactgggc cgcctgaccg tggaagatga agaacgccgc      420

cgccgcgtgg cgggcccgcg caccggcgat gtgaacctga gcggcggcgg cccgcgcggc      480

gcgccgggcg gcggctttgt gccgcgcatg gaaggcgtgc cggaaagccc gtttacccgc      540

accggcgaag gcctggatat tcgcggcaac cagggctttc cgtgggtgcg cccgagcccg      600

ccgcagcagc gcctgccgct gctggaatgc accccgcag                             639


<210>  5
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDAg genotype 1 A polypeptide sequence

<400>  5

Ser Arg Ser Glu Ser Lys Lys Asn Arg Gly Gly Arg Glu Glu Ile Leu 
1               5                   10                  15      


Glu Gln Trp Val Gly Ala Arg Lys Lys Leu Glu Glu Leu Glu Arg Asp 
            20                  25                  30          


Leu Arg Lys Ile Lys Lys Lys Ile Lys Lys Leu Glu Glu Glu Asn Pro 
        35                  40                  45              


Trp Leu Gly Asn Ile Lys Gly Ile Leu Gly Lys Lys Asp Arg Glu Gly 
    50                  55                  60                  


Glu Gly Ala Pro Pro Ala Lys Arg Ala Arg Ala Asp Gln Met Glu Val 
65                  70                  75                  80  


Asp Ser Gly Pro Arg Lys Arg Pro Phe Arg Gly Glu Phe Thr Asp Lys 
                85                  90                  95      


Glu Arg Arg Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys Arg Lys 
            100                 105                 110         


Gln Leu Ser Ser Gly Gly Lys Ser Leu Ser Lys Glu Glu Glu Glu Glu 
        115                 120                 125             


Leu Arg Lys Leu Thr Glu Glu Asp Glu Arg Arg Glu Arg Arg Val Ala 
    130                 135                 140                 


Gly Pro Arg Val Gly Gly Val Asn Pro Leu Glu Gly Gly Thr Arg Gly 
145                 150                 155                 160 


Ala Pro Gly Gly Gly Phe Val Pro Ser Met Gln Gly Val Pro Glu Ser 
                165                 170                 175     


Pro Phe Ala Arg Thr Gly Glu Gly Leu Asp Val Arg Gly Asn Gln Gly 
            180                 185                 190         


Phe Pro Trp Asp Ile Leu Phe Pro Ala Asp Pro Pro Phe Ser Pro Gln 
        195                 200                 205             


Ser Cys Arg Pro Gln 
    210             


<210>  6
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDAg genotype 1 B polypeptide sequence

<400>  6

Ser Arg Ser Glu Ser Lys Lys Asn Arg Gly Gly Arg Glu Glu Val Leu 
1               5                   10                  15      


Glu Gln Trp Val Asn Gly Arg Lys Lys Leu Glu Glu Leu Glu Arg Glu 
            20                  25                  30          


Leu Arg Arg Ala Arg Lys Lys Ile Lys Lys Leu Glu Asp Asp Asn Pro 
        35                  40                  45              


Trp Leu Gly Asn Val Lys Gly Ile Leu Gly Lys Lys Asp Lys Asp Gly 
    50                  55                  60                  


Glu Gly Ala Pro Pro Ala Lys Arg Ala Arg Thr Asp Gln Met Glu Ile 
65                  70                  75                  80  


Asp Ser Gly Pro Arg Lys Arg Pro Leu Arg Gly Gly Phe Thr Asp Arg 
                85                  90                  95      


Glu Arg Gln Asp His Arg Arg Arg Lys Ala Leu Lys Asn Lys Lys Lys 
            100                 105                 110         


Gln Leu Ser Ala Gly Gly Lys Ser Leu Ser Lys Glu Glu Glu Glu Glu 
        115                 120                 125             


Leu Lys Arg Leu Thr Arg Glu Asp Glu Glu Arg Lys Lys Glu Glu His 
    130                 135                 140                 


Gly Pro Ser Arg Leu Gly Val Asn Pro Ser Glu Gly Gly Pro Arg Gly 
145                 150                 155                 160 


Ala Pro Gly Gly Gly Phe Val Pro Ser Met Gln Gly Ile Pro Glu Ser 
                165                 170                 175     


Arg Phe Thr Arg Thr Gly Glu Gly Leu Asp Val Arg Gly Ser Arg Gly 
            180                 185                 190         


Phe Pro Gln Asp Ile Leu Phe Pro Ser Asp Pro Pro Phe Ser Pro Gln 
        195                 200                 205             


Ser Cys Arg Pro Gln 
    210             


<210>  7
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDAg genotype 2 A polypeptide sequence

<400>  7

Ser Gln Ser Glu Thr Arg Arg Gly Arg Arg Gly Thr Arg Glu Glu Thr 
1               5                   10                  15      


Leu Glu Lys Trp Ile Thr Ala Arg Lys Lys Ala Glu Glu Leu Glu Lys 
            20                  25                  30          


Asp Leu Arg Lys Thr Arg Lys Thr Ile Lys Lys Leu Glu Glu Glu Asn 
        35                  40                  45              


Pro Trp Leu Gly Asn Ile Val Gly Ile Ile Arg Lys Gly Lys Asp Gly 
    50                  55                  60                  


Glu Gly Ala Pro Pro Ala Lys Arg Pro Arg Thr Asp Gln Met Glu Val 
65                  70                  75                  80  


Asp Ser Gly Pro Gly Lys Arg Pro His Lys Ser Gly Phe Thr Asp Lys 
                85                  90                  95      


Glu Arg Glu Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys Lys Lys 
            100                 105                 110         


Gln Leu Ser Ala Gly Gly Lys Ile Leu Ser Lys Glu Glu Glu Glu Glu 
        115                 120                 125             


Leu Arg Arg Leu Thr Asp Glu Asp Glu Glu Arg Lys Arg Arg Val Ala 
    130                 135                 140                 


Gly Pro Arg Val Gly Asp Val Asn Pro Ser Arg Gly Gly Pro Arg Gly 
145                 150                 155                 160 


Ala Pro Gly Gly Gly Phe Val Pro Gln Met Ala Gly Val Pro Glu Ser 
                165                 170                 175     


Pro Phe Ser Arg Thr Gly Glu Gly Leu Asp Ile Arg Gly Thr Gln Gly 
            180                 185                 190         


Phe Pro Trp Val Ser Pro Ser Pro Pro Gln Gln Arg Leu Pro Leu Leu 
        195                 200                 205             


Glu Cys Thr Pro Gln 
    210             


<210>  8
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDAg genotype 2 B polypeptide sequence

<400>  8

Ser Gln Ser Glu Ser Lys Lys Asn Arg Arg Gly Gly Arg Glu Asp Ile 
1               5                   10                  15      


Leu Glu Lys Trp Ile Thr Thr Arg Arg Lys Ala Glu Glu Leu Glu Lys 
            20                  25                  30          


Asp Leu Arg Lys Ala Arg Lys Thr Ile Lys Lys Leu Glu Asp Glu Asn 
        35                  40                  45              


Pro Trp Leu Gly Asn Ile Ile Gly Ile Ile Arg Lys Gly Lys Asp Gly 
    50                  55                  60                  


Glu Gly Ala Pro Pro Ala Lys Arg Pro Arg Thr Asp Gln Met Glu Ile 
65                  70                  75                  80  


Asp Ser Gly Thr Gly Lys Arg Pro His Lys Ser Gly Phe Thr Asp Lys 
                85                  90                  95      


Glu Arg Glu Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys Lys Lys 
            100                 105                 110         


Gln Leu Ser Ser Gly Gly Lys Asn Leu Ser Arg Glu Glu Glu Glu Glu 
        115                 120                 125             


Leu Gly Arg Leu Thr Val Glu Asp Glu Glu Arg Arg Arg Arg Val Ala 
    130                 135                 140                 


Gly Pro Arg Thr Gly Asp Val Asn Leu Ser Gly Gly Gly Pro Arg Gly 
145                 150                 155                 160 


Ala Pro Gly Gly Gly Phe Val Pro Arg Met Glu Gly Val Pro Glu Ser 
                165                 170                 175     


Pro Phe Thr Arg Thr Gly Glu Gly Leu Asp Ile Arg Gly Asn Gln Gly 
            180                 185                 190         


Phe Pro Trp Val Arg Pro Ser Pro Pro Gln Gln Arg Leu Pro Leu Leu 
        195                 200                 205             


Glu Cys Thr Pro Gln 
    210             


<210>  9
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PreS1 A DNA sequence

<400>  9
ggcaccaacc tgagcaccag caacccgctg ggcttttttc cggatcatca gctggatccg       60

gcgtttcgcg cgaacagcgc gaacccggat tgggatttta acccgaacaa agatacctgg      120

ccggatgcga acaaagtggg c                                                141


<210>  10
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PreS1 B DNA sequence

<400>  10
ggccagaacc tgagcaccag caacccgctg ggcttttttc cggatcatca gctggatccg       60

gcgtttcgcg cgaacaccgc gaacccggat tgggatttta acccgaacaa agatacctgg      120

ccggatgcga acaaagtggg c                                                141


<210>  11
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PreS1 A polypeptide sequence

<400>  11

Gly Thr Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His 
1               5                   10                  15      


Gln Leu Asp Pro Ala Phe Arg Ala Asn Ser Ala Asn Pro Asp Trp Asp 
            20                  25                  30          


Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly 
        35                  40                  45          


<210>  12
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PreS1 B polypeptide sequence

<400>  12

Gly Gln Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His 
1               5                   10                  15      


Gln Leu Asp Pro Ala Phe Arg Ala Asn Thr Ala Asn Pro Asp Trp Asp 
            20                  25                  30          


Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly 
        35                  40                  45          


<210>  13
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P2A autocatalytic peptide cleavage site DNA sequence

<400>  13
ggaagcggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct       60

ggacct                                                                  66


<210>  14
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A autocatalytic peptide cleavage site polypeptide sequence

<400>  14

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  15
<211>  3198
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Delta-1 codon optimized DNA sequence

<400>  15
atggccagca gaagtgaatc aaaaaagaat cggggagggc gggaagaaat cctggaacag       60

tgggtcggag cacggaagaa actggaagaa ctggagaggg acctgcgcaa gatcaagaag      120

aagatcaaga agctggagga ggagaacccc tggctgggca atatcaaggg catcctgggc      180

aagaaggatc gggagggaga gggagcacca cctgcaaaga gggccagagc cgaccagatg      240

gaggtggata gcggaccaag gaagcgccct ttcagaggag agtttaccga caaggagcgg      300

agagatcaca ggcgccggaa ggccctggag aacaagagga agcagctgag ctccggcggc      360

aagtccctgt ctaaggagga ggaggaggag ctgcgcaagc tgacagagga ggacgagaga      420

agggagagga gggtggcagg acctagggtg ggaggcgtga acccactgga gggaggaacc      480

agaggagcac ctggaggagg attcgtgcca tccatgcagg gagtgcccga gtctcctttt      540

gcccggacag gcgagggcct ggatgtgaga ggcaatcagg gcttcccctg ggacatcctg      600

tttcctgccg atccaccctt ctctcctcag agctgccggc cacagagcag atccgagtct      660

aagaagaaca ggggaggaag agaggaggtg ctggagcagt gggtgaatgg ccggaagaag      720

ctggaggagc tggagcggga gctgagaagg gccagaaaga agatcaagaa gctggaagac      780

gataatcctt ggctgggcaa tgtgaaaggc atcctgggca agaaggacaa ggatggagag      840

ggagcacctc cagcaaagag ggcaagaacc gaccagatgg agatcgattc tggaccaagg      900

aagcgccccc tgagaggagg cttcacagac cgggagagac aggatcaccg ccggagaaag      960

gccctgaaga acaagaagaa gcagctgtcc gccggaggca agagcctgtc caaagaagag     1020

gaagaggagc tgaagaggct gacccgcgag gacgaggaga ggaagaagga ggagcacgga     1080

ccaagcaggc tgggagtgaa tccttccgag ggaggaccta ggggagcacc aggaggaggc     1140

ttcgtgccat ctatgcaggg catccccgag agccggttta ccagaacagg agagggcctg     1200

gacgtgaggg gctcccgcgg ctttcctcag gacatcctgt tcccatctga tccccctttt     1260

tccccccagt cttgtaggcc tcagggcacc aacctgtcta caagcaatcc actgggcttc     1320

tttcccgacc accagctgga tcctgccttc cgcgccaaca gcgccaatcc cgactgggac     1380

ttcaacccaa ataaggacac ctggccagat gccaacaagg tcggcggcca gaacctgtcc     1440

acatctaatc ctctgggctt ctttccagac caccagctgg atccagcctt ccgggccaac     1500

acagctaacc ctgactggga cttcaacccc aataaggata cttggcccga cgccaacaag     1560

gtcggcggaa gcggagctac taacttcagc ctgctgaagc aggctggaga cgtggaggag     1620

aaccctggac ctatgagcca gtccgagaca aggaggggcc ggagaggaac cagggaggag     1680

acactggaga agtggatcac agcccgcaag aaggccgagg agctggagaa ggacctgcgg     1740

aagaccagaa agacaatcaa gaagctggaa gaagagaacc catggctggg caatatcgtg     1800

ggcatcatca gaaagggcaa ggacggcgag ggagcaccac cagcaaagag gcccaggact     1860

gatcagatgg aagtcgatag cggaccaggc aagcggcctc acaagtccgg cttcacagac     1920

aaggagagag aggaccatag gcgccggaag gccctggaaa acaagaagaa gcaattatcc     1980

gccggcggca agatcctgtc caaagaggaa gaagaggagc tgagaaggct gaccgacgag     2040

gatgaggaga ggaaaagaag ggtggcagga ccaagggtgg gcgacgtgaa tcccagcagg     2100

ggaggaccaa gaggcgcccc tggcggcggc ttcgtgccac agatggcagg agtgccagag     2160

agcccctttt ccaggacagg agagggcctg gatatcagag gcacccaggg ctttccttgg     2220

gtgtctccaa gccctccaca gcagcggctg ccactgctgg agtgcacccc tcagtcccag     2280

tctgagagca agaagaacag aaggggcggc agagaggaca tcctggagaa gtggatcacc     2340

acacgcagaa aagctgaaga actggaaaag gacctgagga aggcccgcaa aacaatcaag     2400

aagctggagg atgaaaatcc atggctggga aacatcatcg gcatcatcag gaagggcaag     2460

gacggggaag gcgcaccacc tgcaaagcgg cctagaacag atcagatgga aatcgattct     2520

ggcaccggca agaggccaca caagagcggc ttcaccgaca aggagcgcga ggatcacaga     2580

aggcgcaagg ccctggagaa caagaagaag caattaagca gcggcggcaa gaatctgtcc     2640

agagaagaag aggaggagct gggccgcctg accgtggagg acgaggagcg gagaaggcgc     2700

gtggcaggac cacgcacagg cgatgtgaac ctgtccggag gaggaccaag gggagcacct     2760

ggaggcggct tcgtgcctag aatggaggga gtgcctgagt cccccttcac ccgcaccgga     2820

gagggcctgg acatcagagg caatcaggga ttcccatggg tgaggcccag cccaccacag     2880

cagcgcctgc cactgctgga gtgtaccccc cagggcacaa acctgtccac ctctaatccc     2940

ctgggcttct ttcctgatca tcagctggac ccagccttca gggccaactc cgccaatcca     3000

gattgggact tcaacccgaa taaggatact tggccagatg caaacaaggt cggaggacag     3060

aacctgagca catccaaccc tctgggcttc tttcctgacc atcagctgga tcccgccttt     3120

cgcgccaata ccgccaaccc tgattgggac ttcaacccta ataaggatac ttggcctgat     3180

gctaataagg tcgggtga                                                   3198


<210>  16
<211>  3198
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Delta-2 codon optimized DNA sequence

<400>  16
atggccggca ctaacctgtc tacatcaaac cctctgggat ttttccccga tcatcagctg       60

gaccccgcat ttcgcgctaa ctctgctaac cctgactggg atttcaaccc taataaggac      120

acatggccag atgccaacaa ggtcggcggc cagaacctgt ccacctctaa tcccctgggc      180

ttctttcctg accaccagct ggatcctgcc ttcagggcca acaccgccaa tcccgactgg      240

gacttcaacc caaataagga tacctggcct gacgctaaca aggtcggcag ccggtccgag      300

tctaagaaga ataggggagg aagggaggag atcctggagc agtgggtggg cgccagaaag      360

aagctggagg agctggagcg ggacctgaga aagatcaaga agaagatcaa gaagctggag      420

gaggagaacc cctggctggg caatatcaag ggcatcctgg gcaagaagga tcgggaggga      480

gagggagcac cacctgcaaa gagggccaga gccgaccaga tggaggtgga ttccggccct      540

aggaagcgcc cattcagagg cgagtttaca gacaaggagc ggagagatca caggcgccgg      600

aaggccctgg agaacaagag gaagcagctg agctccggcg gcaagagcct gtccaaggag      660

gaggaggagg agctgcgcaa gctgaccgag gaggacgaga gaagggagag gagggtggca      720

ggacctaggg tgggaggcgt gaacccactg gagggaggaa caagaggagc acccggagga      780

ggcttcgtgc cttctatgca gggcgtgcct gagagcccat ttgccaggac cggagagggc      840

ctggacgtga gaggcaatca gggcttccca tgggacatcc tgtttcccgc cgatccaccc      900

ttcagcccac agtcctgcag gccccagtct cgcagcgagt ccaagaagaa cagaggcgga      960

agggaggagg tgctggagca gtgggtgaat ggcaggaaga agctggaaga actggagagg     1020

gagctgagaa gggcccgcaa gaagatcaag aagctggaag acgataatcc ttggctgggc     1080

aatgtgaaag gcatcctggg caagaaggac aaggatggag agggagcacc tccagcaaag     1140

agggcaagaa cagaccagat ggagatcgat tccggaccaa ggaagcgccc tctgagggga     1200

ggcttcaccg accgggagag acaggatcac cgccggagaa aggccctgaa gaacaagaag     1260

aagcagctga gcgccggcgg caagtctctg agtaaagaag aagaggagga gctgaagcgg     1320

ctgacaagag aggacgagga gaggaagaag gaggagcacg gaccatccag gctgggagtg     1380

aatccttctg agggaggacc aaggggcgcc cctggcggag gcttcgtgcc tagcatgcag     1440

ggcatcccag agtccaggtt taccaggaca ggcgaaggcc tggacgtgcg gggctctaga     1500

ggctttcccc aggacatcct gttccctagc gatccccctt tttctcctca gagctgtaga     1560

ccacagggaa gcggagctac taacttcagc ctgctgaagc aggctggaga cgtggaggag     1620

aaccctggac ctatgggcac caacctgtcc acatctaacc ctctgggctt ctttccagat     1680

catcagctgg acccagcctt cagggccaac agcgccaatc cagactggga cttcaacccc     1740

aataaggaca catggcctga cgcaaacaag gtcggaggac agaacctgag cacctccaat     1800

ccactgggct tctttcccga ccaccagctg gatccagcct tccgcgccaa cactgctaac     1860

cctgattggg acttcaaccc taataaggat acatggcctg atgccaataa ggtcggctct     1920

cagagcgaga caaggagggg ccggagagga accagggagg agacactgga gaagtggatc     1980

accgcccgca agaaggccga ggagctggag aaggacctga ggaagacccg caagacaatc     2040

aagaagctgg aagaagagaa cccatggctg ggcaatatcg tgggcatcat cagaaagggc     2100

aaggacggcg agggagcacc accagcaaag aggccccgca cagatcagat ggaagtggat     2160

tccggacctg gcaagcggcc acacaagtct ggcttcaccg acaaggagag agaggaccat     2220

aggcgccgga aggccctgga aaacaagaag aagcaattat ctgccggcgg caagatcctg     2280

agtaaagaag aggaagagga gctgagaagg ctgaccgacg aggatgagga gaggaagcgc     2340

cgggtggccg gcccacgcgt gggcgacgtg aatccctcca ggggaggacc aagaggagca     2400

cctggaggcg gcttcgtgcc ccagatggcc ggcgtgcccg agtccccttt ttctcggacc     2460

ggcgagggcc tggatatcag aggcacacag ggctttccat gggtgtcccc ctctcctcca     2520

cagcagaggc tgccactgct ggagtgcaca ccccagagcc agagcgaatc taagaagaac     2580

agaaggggag gccgcgagga catcctggaa aaatggatca ccacacgcag aaaagctgaa     2640

gaactggaaa aggacctgcg gaaggccaga aagaccatca agaagctgga ggatgaaaat     2700

ccatggctgg gaaacatcat cggcatcatc cggaagggca aggacgggga aggcgcacca     2760

cctgcaaagc ggcctagaac cgatcagatg gaaatcgata gcggcacagg caagaggcca     2820

cacaagtccg gcttcaccga taaagagcgc gaggatcaca gaaggcgcaa ggccctggag     2880

aacaagaaga agcaattaag cagcggcggc aagaatctgt ccagagaaga ggaggaagag     2940

ctgggccgcc tgacagtgga ggacgaggag cggagaaggc gcgtggcagg acccagaacc     3000

ggcgatgtga acctgtccgg aggaggacct aggggagcac caggaggcgg cttcgtgcct     3060

agaatggagg gcgtgccaga gtctcccttt acccggacag gcgagggcct ggacatcaga     3120

ggcaatcagg gctttccctg ggtccgcccc tccccccctc agcagagact gccactgctg     3180

gaatgcacac cacagtga                                                   3198


<210>  17
<211>  3762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Delta-3 codon optimized DNA sequence

<400>  17
atggccggca ccaatctgtc tacctcaaat cccctgggct tcttccccga tcatcagctg       60

gaccctgcct tccgagcaaa ttccgctaat cctgattggg atttcaaccc aaataaggac      120

acatggccag atgccaacaa ggtcggcggc cagaacctgt ccacctctaa tcctctgggc      180

ttctttccag accaccagct ggatcccgcc ttcagggcca acacagccaa tcccgactgg      240

gacttcaacc ctaataagga cacctggcct gacgccaaca aggtcggcag caggtccgag      300

tctaagaaga ataggggagg aagggaggag atcctggagc agtgggtggg agcacgcaag      360

aagctggagg agctggagcg ggacctgaga aagatcaaga agaagatcaa gaagctggag      420

gaggagaacc cctggctggg caatatcaag ggcatcctgg gcaagaagga tcgggaggga      480

gagggagcac cacctgcaaa gagggccaga gccgaccaga tggaggtgga ttccggacca      540

aggaagcgcc ctttcagagg agagtttaca gacaaggagc ggagagatca caggcgccgg      600

aaggccctgg agaacaagcg gaagcagctg agctccggcg gcaagagcct gtccaaggag      660

gaggaggagg agctgagaaa gctgaccgag gaggacgaga gaagggagag gagggtggcc      720

ggccccaggg tgggcggcgt gaaccctctg gagggaggaa caaggggagc accaggagga      780

ggcttcgtgc cttccatgca gggcgtgccc gagtctcctt ttgccaggac cggagagggc      840

ctggacgtgc gcggcaatca gggcttccca tgggacatcc tgtttcccgc cgatccaccc      900

ttctctcccc agagctgcag gcctcagtct cgcagcgagt ccaagaagaa cagaggcgga      960

agggaggagg tgctggagca gtgggtgaat ggcaggaaga agctggaaga actggagagg     1020

gagctgagaa gggcccgcaa gaagatcaag aagctggaag acgataatcc ttggctgggc     1080

aatgtgaaag gcatcctggg caagaaggac aaggatggag agggagcacc tccagcaaag     1140

agggcaagaa cagaccagat ggagatcgat tctggaccaa ggaagcgccc cctgagggga     1200

ggcttcaccg accgggagag acaggatcac cgccggagaa aggccctgaa gaacaagaag     1260

aagcagctga gcgccggcgg caagtctctg agtaaagaag aagaggagga gctgaagcgg     1320

ctgaccagag aggacgagga gcggaagaag gaggagcacg gcccaagcag actgggagtg     1380

aatccatccg agggaggacc tagaggcgcc cctggcggcg gcttcgtgcc ttctatgcag     1440

ggcatcccag agagcaggtt taccaggaca ggcgaaggcc tggacgtgcg gggctccaga     1500

ggctttcccc aggacatcct gttcccttct gatccccctt tttccccaca gtcttgtagg     1560

ccccagggca ccaacctgtc cacatctaac ccactgggct tctttcctga tcaccagctg     1620

gatccagcct tccgcgccaa ctccgccaat ccagactggg acttcaaccc caataaggac     1680

acatggcctg atgctaacaa ggtcggaggc cagaacctga gcacctccaa tcccctgggc     1740

ttctttcctg accaccagct ggatcctgcc ttccgcgcca acacagctaa ccctgattgg     1800

gacttcaacc caaataagga tacctggcct gatgcaaaca aggtcggagg aagcggagct     1860

actaacttca gcctgctgaa gcaggctgga gacgtggagg agaaccctgg acctatgggc     1920

accaacctgt ctacaagcaa tccactgggc ttctttcccg accatcagct ggacccagcc     1980

ttcagggcca acagcgccaa ccctgactgg gacttcaacc caaataagga cacgtggcct     2040

gatgccaaca aggtcggagg acaaaacctg tccacctcta accccctggg cttctttccc     2100

gatcatcaat tagacccagc cttccgcgct aacactgcta accctgactg ggacttcaac     2160

ccgaataagg atacttggcc tgatgccaat aaggtcggca gccagtccga gacaaggagg     2220

ggccggagag gaaccaggga ggagacactg gagaagtgga tcaccgccag aaagaaggcc     2280

gaggagctgg agaaggacct gaggaagacc cgcaagacaa tcaagaagct ggaagaagag     2340

aacccttggc tgggcaatat cgtgggcatc atcagaaagg gcaaggacgg cgagggagca     2400

ccaccagcca agaggccacg cacagatcag atggaagtgg atagcggacc aggcaagagg     2460

cctcacaagt ccggcttcac cgacaaggag agggaggacc ataggcgccg gaaggccctg     2520

gaaaacaaga agaagcaatt atccgccggc ggcaagatcc tgtctaaaga agaggaagaa     2580

gagctgagaa ggctgaccga cgaggatgag gagaggaaga ggagggtggc aggacctaga     2640

gtgggcgacg tgaatccatc caggggagga ccaagaggag caccaggagg cggcttcgtg     2700

ccacagatgg caggagtgcc agagagcccc ttttccagga caggagaggg cctggatatc     2760

aggggaaccc agggctttcc ttgggtgtct ccaagccctc cacagcagcg gctgccactg     2820

ctggagtgca caccccagtc ccagtctgag agcaagaaga acagaagggg cggcagagag     2880

gacatcctgg aaaaatggat caccacacgc agaaaagctg aagaactgga aaaggacctg     2940

cggaaggcca gaaagaccat caagaagctg gaggatgaaa atccatggct gggaaatatc     3000

atcggcatca tccggaaggg caaggacggg gaaggcgcac cacctgcaaa gcggcccagg     3060

accgatcaga tggaaatcga ttctggaacc ggcaagcggc ctcacaagag tggcttcacc     3120

gataaggaga gagaggatca cagaaggcgc aaggccctgg agaacaagaa gaagcaatta     3180

agcagcggcg gcaagaatct gtccagagaa gaggaagagg agctgggcag actgacagtg     3240

gaggacgagg agcggagaag gcgcgtggca ggaccaagaa ccggcgatgt gaacctgtcc     3300

ggaggaggac caaggggagc acctggggga ggcttcgtgc caaggatgga gggagtgcct     3360

gagtccccct tcaccagaac cggcgaaggc ctggacatca ggggcaatca gggattccca     3420

tgggtgcggc cctccccacc ccagcagaga ctgcctctgc tggagtgtac cccacagggc     3480

actaacctgt ccacctctaa cccgttaggc ttctttcctg accatcaatt agatcccgcc     3540

ttccgggcca acagcgccaa tcctgattgg gacttcaacc cgaataagga cacctggccc     3600

gacgcaaaca aggtcggagg gcaaaacctg agcacctcca accctttagg cttctttcca     3660

gatcatcagc tggatccagc ctttagagcc aataccgcca accctgactg ggatttcaac     3720

cctaacaaag atacctggcc cgacgctaac aaagtgggat ga                        3762


<210>  18
<211>  3900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Delta-4 codon optimized DNA sequence

<400>  18
atggccagtc ggagcgaatc aaagaaaaat aggggagggc gggaagaaat cctggagcag       60

tgggtcggag cacgaaagaa actggaagaa ctggagaggg acctgcgcaa gatcaagaag      120

aagatcaaga agctggagga ggagaacccc tggctgggca atatcaaggg catcctgggc      180

aagaaggatc gggagggaga gggagcacca cctgcaaaga gggccagagc cgaccagatg      240

gaggtggata gcggccctag gaagcgccca ttcagaggcg agtttacaga caaggagcgg      300

agagatcaca ggcgccggaa ggccctggag aacaagcgga agcagctgag ctccggcggc      360

aagtccctgt ctaaggagga ggaggaggag ctgagaaagc tgaccgagga ggacgagaga      420

agggagagga gggtggcagg acctagggtg ggaggcgtga acccactgga gggaggaaca      480

aggggagcac ctggaggagg attcgtgcca tccatgcagg gagtgcctga gtctccattt      540

gccaggaccg gagagggcct ggatgtgcgc ggaaatcagg gcttcccctg ggacatcctg      600

tttcctgccg atccaccctt ctccccacag tcttgcaggc cacagggaac caacctgagc      660

acatccaatc ctctgggctt ctttccagac caccagctgg atcctgcctt cagagccaac      720

tccgccaatc cagactggga cttcaacccc aataaggaca catggcctga tgccaacaag      780

gtcggcggcc agaacctgtc taccagcaat cccctgggct tctttcctga ccaccagctg      840

gatccagcct tccgggccaa cactgctaac cctgattggg acttcaaccc taataaggat      900

acctggccag acgccaacaa ggtcggcgga agcggagcta ctaacttcag cctgctgaag      960

caggctggag acgtggagga gaaccctgga cctatgtcca ggtctgagag caagaagaat     1020

aggggaggaa gagaggaggt gctggagcag tgggtgaacg gccgcaagaa gctggaggag     1080

ctggagaggg agctgagaag ggcccgcaag aagatcaaga agctggaaga cgataatcct     1140

tggctgggca atgtgaaagg catcctgggc aagaaggaca aggatggaga gggagcacct     1200

ccagcaaaga gggcaagaac agaccagatg gagatcgatt ctggaccaag gaagcgccct     1260

ctgaggggag gcttcaccga ccgggagaga caggatcacc gccggagaaa ggccctgaag     1320

aacaagaaga agcagctgtc cgccggcggc aagtccctga gcaaagaaga ggaagaggag     1380

ctgaagaggc tgacccgcga ggacgaggag cggaagaagg aggagcacgg accaagcaga     1440

ctgggagtga atccttccga gggaggacca agaggagcac ccggaggagg cttcgtgcca     1500

tctatgcagg gcatccccga gagccggttt accagaacag gagagggcct ggacgtgagg     1560

ggctcccgcg gctttcctca ggacatcctg ttcccatctg atcccccttt tagcccacag     1620

tcctgtaggc cccagggcac taacctgagc acatccaacc cactgggctt ctttcctgat     1680

catcagctgg acccagcctt ccgcgccaac agcgccaacc ctgactggga cttcaaccca     1740

aataaggaca catggccaga tgctaacaag gtcggaggac aaaacctgtc taccagcaac     1800

cctctgggct tctttcccga tcatcagctg gaccccgcct tcagggccaa cacagccaat     1860

cccgactggg acttcaaccc gaataaggac acctggccag atgcaaacaa ggtcggagga     1920

agcggagcta ctaacttcag cctgctgaag caggctggag acgtggagga gaaccctgga     1980

cctatgagcc agtctgagac aaggaggggc cggagaggaa ccagggagga gacactggag     2040

aagtggatca ccgccagaaa gaaggccgag gagctggaga aggacctgcg gaagaccaga     2100

aagacaatca agaagctgga agaagagaac ccatggctgg gcaatatcgt gggcatcatc     2160

cgcaagggca aggacggcga gggagcacca ccagcaaaga ggccccgcac agatcagatg     2220

gaagtggata gcggccctgg caagaggcca cacaagtccg gcttcaccga caaggagagg     2280

gaggaccata ggcgccggaa ggccctggaa aacaagaaga agcaattatc cgccggcggc     2340

aagatcctgt ccaaagagga agaagaggag ctgagaaggc tgaccgacga ggatgaggag     2400

aggaaaagaa gggtggcagg accaagagtg ggcgacgtga atcccagcag aggcggacca     2460

agaggagcac ctggaggcgg cttcgtgccc cagatggccg gcgtgcccga gtctcctttt     2520

agcagaactg gagagggcct ggatatcagg ggaacacagg gctttccatg ggtgagccca     2580

tcccctccac agcagaggct gccactgctg gagtgcaccc ctcagggaac caacctgtct     2640

accagcaacc cgctgggctt ctttcccgac catcagctgg accctgcctt ccgcgccaac     2700

tccgccaacc ctgattggga cttcaacccg aataaggata cctggcccga cgctaacaag     2760

gtcggaggcc agaacctgtc cacctctaac cccttaggct tctttcccga tcaccagctg     2820

gatcccgcct tcagagccaa cactgctaac cccgattggg acttcaaccc gaataaggac     2880

acgtggccag acgctaacaa ggtcggggga agcggagcta ctaacttcag cctgctgaag     2940

caggctggag acgtggagga gaaccctgga cctatgtcgc agtccgagtc taagaagaat     3000

agaaggggcg gccgggagga tatcctggaa aaatggatca ccacacgcag aaaagctgaa     3060

gaactggaaa aggacctgag gaaggcccgc aagaccatca agaagctgga ggatgaaaat     3120

ccatggctgg gaaacatcat cggcatcatc agaaagggca aggacgggga aggcgcccca     3180

cctgcaaagc ggcctagaac cgatcagatg gaaatcgatt ctggcacagg caagcggcca     3240

cacaagagtg gcttcaccga taaggagaga gaggatcaca gaaggcgcaa ggccctggag     3300

aacaagaaga agcaattaag cagcggcggc aagaatctgt ccagagaaga agaggaggag     3360

ctgggcagac tgacagtgga ggacgaggag cggagaaggc gcgtggcagg accaaggacc     3420

ggcgatgtga acctgagcgg aggaggacct aggggagcac caggaggcgg cttcgtgcct     3480

aggatggagg gagtgccaga gtcccccttt accaggactg gcgagggcct ggacatcagg     3540

ggaaatcagg gattcccatg ggtgcggcct agcccaccac agcagagact gccactgctg     3600

gagtgtacac cccagggcac aaacctgagc acatccaatc cgctgggctt ctttccagat     3660

catcaattag atccagcctt cagggccaac tccgccaatc cggattggga cttcaacccg     3720

aataaggaca cttggcccga cgcaaacaag gtcggagggc aaaacctgtc taccagcaat     3780

ccacttggct tctttcctga ccatcagctg gatcccgcct ttcgcgccaa taccgccaat     3840

cctgactggg acttcaatcc taacaaagac acctggcccg acgcaaacaa agtgggatga     3900


<210>  19
<211>  2634
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Delta-5 codon optimized DNA sequence

<400>  19
atggcctcac ggtcagagtc aaagaaaaat aggggggggc gggaagaaat cctggaacag       60

tgggtcggag cacggaaaaa actggaagag ctggagaggg acctgcgcaa gatcaagaag      120

aagatcaaga agctggagga ggagaacccc tggctgggca atatcaaggg catcctgggc      180

aagaaggatc gggagggaga gggagcacca cctgcaaaga gggccagagc cgaccagatg      240

gaggtggata gcggccctag gaagcgccca ttcagaggcg agtttaccga caaggagcgg      300

agagatcaca ggcgccggaa ggccctggag aacaagcgga agcagctgag ctccggcggc      360

aagtccctgt ctaaggagga ggaggaggag ctgagaaagc tgacagagga ggacgagaga      420

agggagcgcc gggtggccgg cccaagggtg ggcggcgtga accccctgga gggaggaacc      480

aggggagcac ctggaggagg cttcgtgcca tctatgcagg gcgtgcctga gagcccattt      540

gccaggacag gagagggcct ggatgtgcgc ggcaatcagg gcttcccctg ggacatcctg      600

tttcctgccg atccaccctt cagcccacag tcctgcaggc ctcagagcag atccgagtct      660

aagaagaaca ggggaggaag agaggaggtg ctggagcagt gggtgaatgg ccggaagaag      720

ctggaggagc tggagcggga gctgagaagg gccagaaaga agatcaagaa gctggaagac      780

gataatcctt ggctgggcaa tgtgaaaggc atcctgggca agaaggacaa ggatggagag      840

ggagcacctc cagcaaagag ggcaagaacc gaccagatgg agatcgatag cggaccaagg      900

aagcgccctc tgagaggagg cttcacagac cgggagagac aggatcaccg ccggagaaag      960

gccctgaaga acaagaagaa gcagctgtcc gccggaggca agagcctgtc caaagaagag     1020

gaagaggagc tgaagaggct gacccgcgag gacgaggagc ggaagaagga ggagcacggc     1080

ccttccagac tgggcgtgaa tccatctgag ggaggaccaa ggggagcacc aggcggcggc     1140

ttcgtgccaa gcatgcaggg catccccgag tcccggttta ccagaacagg agagggcctg     1200

gacgtgaggg gctctcgcgg ctttcctcag gacatcctgt tcccaagcga tccccctttt     1260

tctccacaga gctgtcgccc ccagggaagc ggagctacta acttcagcct gctgaagcag     1320

gctggagacg tggaggagaa ccctggacct atgtctcaga gcgagacaag gaggggccgg     1380

agaggaacca gggaggagac actggagaag tggatcacag ccagaaagaa ggccgaggag     1440

ctggagaagg acctgcggaa gaccagaaag acaatcaaga agctggaaga agaaaatcca     1500

tggctgggaa atatcgtggg catcatcagg aagggcaagg acggcgaggg agcaccacca     1560

gccaagaggc ctcgcactga tcagatggag gtggattccg gccctggcaa gaggccacac     1620

aagtctggct tcacagacaa ggagagggag gaccataggc gccggaaggc cctggaaaac     1680

aagaagaagc aattatctgc cggcggcaag atcctgagca aagaggaaga ggaggagctg     1740

agaaggctga ccgacgagga tgaggagagg aagaggaggg tggcaggacc aagagtgggc     1800

gacgtgaatc ctagcagagg cggaccaaga ggcgccccag gcgggggctt cgtgccacag     1860

atggcaggag tgccagagtc ccctttttct aggaccggag agggcctgga tatcagggga     1920

acacagggct ttccatgggt gtccccatct cctccacagc agaggctgcc actgctggag     1980

tgcacccctc agagccagtc cgagtctaag aagaatagaa ggggcggccg cgaggacatc     2040

ctggagaagt ggatcaccac acgcagaaaa gctgaagaac tggaaaagga cctgaggaag     2100

gcccgcaaaa caatcaagaa gctggaggat gagaaccctt ggctgggcaa tatcatcgga     2160

attatcagga agggcaagga tggcgaaggc gccccacctg caaagcggcc aaggactgat     2220

cagatggaaa tcgatagcgg aacaggcaag cggccccaca agtccggctt caccgacaag     2280

gagagagagg atcacagaag gcgcaaggcc ctggagaaca agaagaagca attaagcagc     2340

ggcggcaaga atctgtccag agaagaagag gaggagctgg gcagactgac cgtggaggac     2400

gaggagcgga gaaggcgcgt ggcaggacct cgcacaggcg atgtgaacct gtccggagga     2460

ggacctaggg gagcaccagg aggcggcttc gtgccacgca tggagggcgt gccagagtct     2520

ccctttaccc gcaccggaga gggcctggac atcaggggca atcagggctt tccctgggtc     2580

cgcccctccc cccctcagca gagactgccc ctgctggaat gcacaccaca gtga           2634


<210>  20
<211>  2772
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Delta-6 codon optimized DNA sequence

<400>  20
atggcctcac ggtcagagtc aaagaagaac agaggcggaa gagaagaaat cctggagcag       60

tgggtcggag cacggaaaaa gctggaagaa ctggagaggg acctgcgcaa gatcaagaag      120

aagatcaaga agctggagga ggagaacccc tggctgggca atatcaaggg catcctgggc      180

aagaaggata gggagggaga gggagcacca cctgcaaaga gggccagagc cgaccagatg      240

gaggtggata gcggaccaag gaagcgcccc ttccgcggag agtttaccga caaggagcgg      300

agagatcaca ggcgccggaa ggccctggag aacaagagga agcagctgag ctccggcggc      360

aagtccctgt ctaaggagga ggaggaggag ctgcgcaagc tgacagagga ggacgagaga      420

agggagagga gggtggcagg accaagggtg ggaggagtga atcctctgga gggaggaacc      480

agaggagcac caggaggagg cttcgtgcca agcatgcagg gagtgccaga gtcccccttt      540

gccaggacag gagagggcct ggacgtgaga ggcaaccagg gcttcccttg ggacatcctg      600

tttccagccg atccaccctt cagccctcag tcctgcaggc cacagggaag cggagctact      660

aacttcagcc tgctgaagca ggctggagac gtggaggaga accctggacc tatgagccgg      720

tccgagtcta agaagaatag gggaggaaga gaggaggtgc tggagcagtg ggtgaacggc      780

agaaagaagc tggaggagct ggagagggag ctgagaaggg cccgcaagaa gatcaagaag      840

ctggaagacg ataatccttg gctgggcaat gtgaaaggca tcctgggcaa gaaggacaag      900

gatggagagg gagcacctcc agcaaagagg gcaagaaccg accagatgga gatcgatagc      960

ggacctagga agcgcccact gaggggaggc tttacagacc gggagagaca ggatcaccgc     1020

cggagaaagg ccctgaagaa caagaagaag cagctgtccg ccggaggcaa gagcctgtcc     1080

aaagaagagg aagaggagct gaagaggctg acccgcgagg acgaggagag gaagaaggag     1140

gagcacggac catctaggct gggagtgaat cccagcgagg gaggaccaag gggagcacct     1200

ggaggaggct tcgtgccctc catgcagggc atccctgagt ctcggtttac cagaaccggc     1260

gagggcctgg acgtgagggg cagccgcggc tttccacagg acatcctgtt cccctccgat     1320

cccccttttt ctccccagag ctgtcgccct caaggaagcg gagctactaa cttcagcctg     1380

ctgaagcagg ctggagacgt ggaggagaac cctggaccta tgtctcagag cgagacaagg     1440

aggggccgga gaggaaccag ggaggagaca ctggagaagt ggatcacagc ccgcaagaag     1500

gccgaggagc tggagaagga cctgcggaag accagaaaga caatcaagaa gctggaagaa     1560

gagaaccctt ggctgggcaa tatcgtgggc atcatcagga agggcaagga cggcgaggga     1620

gcaccaccag ccaagaggcc acgcactgat cagatggagg tggattctgg accaggcaag     1680

cggccccaca agagcggctt cacagacaag gagagagagg accataggcg ccggaaggcc     1740

ctggaaaaca agaagaagca attaagcgcc ggcggcaaga tcctgtccaa agaggaagag     1800

gaggagctga gaaggctgac cgacgaggat gaggagagga aaagaagggt ggcaggacct     1860

agggtgggcg acgtgaatcc aagcagggga ggacctagag gagcaccagg aggcggcttc     1920

gtgccacaga tggcaggagt gcctgagtcc ccattttctc ggaccggcga gggcctggat     1980

atcagaggca cacagggctt cccctgggtg tccccttctc ctccacagca gcggctgcct     2040

ctgctggagt gcacccctca gggaagcgga gctactaact tcagcctgct gaagcaggct     2100

ggagacgtgg aggagaaccc tggacctatg tcgcagagcg aatctaagaa gaatagaagg     2160

ggcggcagag aggatatcct ggagaagtgg atcaccacac gcagaaaagc tgaagaactg     2220

gaaaaggacc tgaggaaggc ccgcaagacc atcaagaagc tggaggatga aaatccatgg     2280

ctgggaaata tcatcggcat catccggaag ggcaaggacg gggaaggcgc cccacctgca     2340

aagcggccca ggactgatca gatggaaatc gattccggca caggcaagag gcctcacaag     2400

tctggcttca cagataaaga gcgcgaggat cacagaaggc gcaaggccct ggagaacaag     2460

aagaagcaat tatctagcgg cggcaagaat ctgtccagag aagaagagga ggagctgggc     2520

cgcctgaccg tggaggacga ggagcggaga aggcgcgtgg caggaccaag aacaggcgat     2580

gtgaacctgt ctggaggcgg cccaaggggc gcccccggcg gaggcttcgt gccaagaatg     2640

gaaggcgtgc cagagtcccc ttttacccgg acaggggaag gcctggacat tagaggcaat     2700

cagggctttc cctgggtgcg accaagcccc cctcagcagc gactgcctct gctggagtgt     2760

acccctcagt ga                                                         2772


<210>  21
<211>  1569
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Delta-7 codon optimized DNA sequence

<400>  21
atggcctcac ggtctgagtc aaagaagaat cgggggggaa gagaagaaat cctggaacag       60

tgggtcggcg cacggaaaaa actggaagaa ctggagcggg acctgagaaa gatcaagaag      120

aagatcaaga agctggagga agagaacccc tggctgggca atatcaaggg catcctgggc      180

aagaaggatc gggagggcga gggagcacca cctgcaaaga gggcaagggc agaccagatg      240

gaggtggatt ccggacctag gaagcggccc ttccggggag agtttaccga caaggagcgg      300

agagatcaca ggcgccggaa ggccctggag aacaagcgga agcagctgag ctccggcggc      360

aagtctctga gcaaggagga ggaggaggag ctgagaaagc tgacagagga ggacgagaga      420

agggagcgcc gggtggccgg cccaagggtg ggcggcgtga accccctgga gggaggaacc      480

aggggagcac caggaggagg cttcgtgcct tctatgcagg gcgtgccaga gagccccttt      540

gccaggacag gagagggcct ggatgtgcgc ggcaatcagg gcttcccatg ggacatcctg      600

tttcccgccg atccaccctt ctcccctcag tcttgcaggc cacagtcccg ctctgagagc      660

aagaagaaca ggggaggaag ggaggaggtg ctggagcagt gggtgaatgg caggaagaag      720

ctggaggagc tggagcggga gctgagaagg gccagaaaga agatcaagaa gctggaagac      780

gataatcctt ggctgggcaa tgtgaaaggc atcctgggca agaaggacaa ggatggagag      840

ggagcacctc cagcaaagag ggcacgcacc gaccagatgg agatcgattc cggaccaagg      900

aagcggcccc tgaggggagg cttcacagac agggagcgcc aggatcaccg ccggagaaag      960

gccctgaaga acaagaagaa gcagctgtct gccggcggca agtccctgtc taaagaagag     1020

gaggaggagc tgaagcggct gaccagagag gacgaggagc ggaagaagga ggagcacggc     1080

ccttccagac tgggcgtgaa tccatctgag ggaggaccaa gaggcgcccc tggcggaggc     1140

ttcgtgccta gcatgcaggg catcccagag tccaggttta ccagaaccgg agagggcctg     1200

gacgtgcggg gctctagagg ctttccccag gacatcctgt tccctagcga tccccctttt     1260

agcccccagt cctgtaggcc tcagggcacc aacctgagca catccaatcc actgggcttc     1320

tttccagacc accagctgga tccagccttc cgcgccaaca gcgccaatcc agactgggac     1380

ttcaacccca ataaggacac ctggcctgat gccaacaagg tcggcggcca gaacctgtct     1440

acaagcaatc ctctgggctt ctttcctgat caccagctgg atcctgcctt tcgggccaat     1500

acagccaacc ctgactggga cttcaatcct aacaaagaca cttggcccga tgctaataag     1560

gtcggctga                                                             1569


<210>  22
<211>  1569
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Delta-8 codon optimized DNA sequence

<400>  22
atggccagtc agagcgagac ccgcagagga cggagaggaa cacgagaaga gacactggag       60

aaatggatta cagcacggaa gaaggcagaa gagctggaga aggacctgag gaagacccgc      120

aagacaatca agaagctgga ggaggagaac ccctggctgg gcaatatcgt gggcatcatc      180

aggaagggca aggatggaga gggagcacca cctgccaaga ggcctcgcac agaccagatg      240

gaggtggata gcggaccagg caagcggcct cacaagtccg gcttcaccga caaggagaga      300

gaggatcacc ggagaaggaa ggccctggag aacaagaaga agcagctgtc cgccggcggc      360

aagatcctgt ctaaggagga ggaggaggag ctgcgccggc tgacagacga ggatgaggag      420

aggaagagaa gggtggcagg accaagggtg ggcgacgtga atccttctag gggaggacca      480

aggggagcac caggaggagg cttcgtgcct cagatggccg gcgtgccaga gtctcccttt      540

agccggacag gcgagggcct ggatatcaga ggcacccagg gctttccttg ggtgtctcca      600

agcccaccac agcagcggct gccactgctg gagtgcacac cccagtccca gtctgagagc      660

aagaagaaca ggaggggagg aagagaggac atcctggaga agtggatcac cacaagaagg      720

aaggccgagg agctggagaa ggacctgcgg aaggccagaa agaccatcaa gaagctggag      780

gatgaaaatc cttggctggg aaatatcatc ggaattatta gaaaaggcaa ggacggagag      840

ggagcacctc cagcaaagcg gccaagaaca gaccagatgg agatcgattc tggaaccggc      900

aagaggcccc acaagagtgg cttcaccgat aaggagcgcg aggatcaccg ccggagaaag      960

gccctggaaa acaagaagaa gcaattaagc tccggcggca agaatctgag cagagaagaa     1020

gaggaggagc tgggccgcct gacagtggag gacgaggaga ggcgccggag agtggcagga     1080

cctagaaccg gcgatgtgaa cctgtccgga ggcggcccaa ggggagcacc tggaggcggc     1140

ttcgtgccac gcatggaggg cgtgcctgag tctcccttca ccaggacagg agagggcctg     1200

gacatcagag gcaatcaggg attcccatgg gtgcggccca gcccacctca gcagagactg     1260

cctctgctgg agtgtacccc acagggcaca aacctgtcca cctctaatcc tctgggcttc     1320

tttccagacc accagctgga tccagccttc agggccaact ccgccaaccc tgactgggac     1380

ttcaacccta ataaggacac atggccagat gccaacaagg tcggcggcca gaacctgagc     1440

acctccaatc ccctgggctt ctttcctgac caccagctgg atcccgcctt tcgcgccaat     1500

accgccaatc ccgactggga cttcaatcca aataaggaca cctggcccga tgctaacaaa     1560

gtgggatga                                                             1569


<210>  23
<211>  1287
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Delta-9 codon optimized DNA sequence

<400>  23
atggccagtc ggagcgaatc aaagaaaaat agagggggaa gagaagaaat cctggagcag       60

tgggtcgggg cacggaaaaa actggaagaa ctggagcggg acctgagaaa gatcaagaag      120

aagatcaaga agctggagga agagaacccc tggctgggca atatcaaggg catcctgggc      180

aagaaggata gggagggcga gggagcacca cctgcaaaga gggcaagggc agaccagatg      240

gaggtggatt ccggaccaag gaagcggccc ttccggggag agtttaccga caaggagcgg      300

agagatcaca ggcgccggaa ggccctggag aacaagcgga agcagctgag ctccggcggc      360

aagtctctga gcaaggagga ggaggaggag ctgagaaagc tgacagagga ggacgagaga      420

agggagagga gggtggcagg acctagggtg ggaggcgtga acccactgga gggaggaacc      480

aggggagcac ctggaggagg ctttgtgcca tctatgcagg gagtgccaga gagccctttc      540

gccaggacag gagagggcct ggatgtgcgc ggcaatcagg gcttcccctg ggacatcctg      600

tttcctgccg atccaccctt cagcccacag tcctgcaggc cacagtcccg ctctgagagc      660

aagaagaaca ggggaggaag ggaggaggtg ctggagcagt gggtgaatgg ccggaagaag      720

ctggaggagc tggagcggga gctgagaagg gccagaaaga agatcaagaa gctggaagac      780

gataatcctt ggctgggcaa tgtgaaaggc atcctgggca agaaggacaa ggatggagag      840

ggagcacctc cagcaaagag ggcacgcacc gaccagatgg agatcgattc tggacctagg      900

aagcggcccc tgagaggagg ctttacagac agggagcgcc aggatcaccg ccggagaaag      960

gccctgaaga acaagaagaa gcagctgagc gccggcggca agtccctgtc taaagaagag     1020

gaggaggagc tgaagcggct gaccagagag gacgaggagc ggaagaagga ggagcacgga     1080

ccatccagac tgggagtgaa tccttctgag ggaggaccaa gaggcgcccc aggcggcggc     1140

tttgtgccaa gcatgcaggg catccccgag tccaggttca ccagaaccgg cgaaggcctg     1200

gatgtgcggg gcagcagagg cttcccccag gatattctgt ttccctccga cccccccttc     1260

agtccccagt cttgccgacc tcagtga                                         1287


<210>  24
<211>  1287
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Delta-10 codon optimized DNA sequence

<400>  24
atggcctcac agagcgaaac acggcggggg cggaggggaa ctagagagga aacactggaa       60

aaatggatta cagcacggaa aaaggcagag gaactggaga aggacctgag gaagacccgc      120

aagacaatca agaagctgga ggaggagaac ccatggctgg gcaatatcgt gggcatcatc      180

cggaagggca aggatggaga gggagcacca cctgcaaaga ggccccgcac cgaccagatg      240

gaggtggatt ctggccctgg caagaggcca cacaagagcg gcttcacaga caaggagcgc      300

gaggatcacc ggagaaggaa ggccctggag aacaagaaga agcagctgag cgccggcggc      360

aagatcctgt ccaaggagga ggaggaggag ctgcgccggc tgaccgacga ggatgaggag      420

cggaagagaa gggtggcagg accaagagtg ggcgacgtga atccctctag gggaggacca      480

aggggagcac ctggaggagg cttcgtgcct cagatggcag gagtgccaga gtcccctttt      540

tctaggaccg gagagggcct ggatatcagg ggaacacagg gctttccatg ggtgtctcca      600

agcccaccac agcagaggct gccactgctg gagtgcaccc ctcagtccca gtctgagagc      660

aagaagaaca ggaggggagg aagggaggac atcctggaga agtggatcac cacaagaagg      720

aaggccgagg agctggagaa ggacctgcgg aaggccagaa aaacaatcaa gaagctggaa      780

gatgagaacc cctggctggg caatatcatc ggcatcatca gaaaaggcaa ggacggcgag      840

ggagcacctc cagcaaagcg gcctagaacc gaccagatgg agatcgattc cggcacaggc      900

aagcggccac acaagtctgg cttcaccgac aaggagagag aggatcaccg ccggagaaag      960

gccctggaaa acaagaagaa gcaattaagc tccggcggca agaatctgag cagagaagaa     1020

gaggaggagc tgggcagact gaccgtggag gacgaggaga ggcgccggag agtggcagga     1080

cccagaacag gcgatgtgaa cctgagcgga ggaggaccta ggggagcacc aggaggcggc     1140

ttcgtgccta gaatggaggg cgtgccagag tcccccttta ccaggacagg agagggcctg     1200

gacatcaggg gcaatcaggg ctttccctgg gtccgccctt caccaccaca gcagagactg     1260

cccctgctgg aatgcacacc acagtga                                         1287


<210>  25
<211>  1065
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Delta-1 polypeptide sequence

<400>  25

Met Ala Ser Arg Ser Glu Ser Lys Lys Asn Arg Gly Gly Arg Glu Glu 
1               5                   10                  15      


Ile Leu Glu Gln Trp Val Gly Ala Arg Lys Lys Leu Glu Glu Leu Glu 
            20                  25                  30          


Arg Asp Leu Arg Lys Ile Lys Lys Lys Ile Lys Lys Leu Glu Glu Glu 
        35                  40                  45              


Asn Pro Trp Leu Gly Asn Ile Lys Gly Ile Leu Gly Lys Lys Asp Arg 
    50                  55                  60                  


Glu Gly Glu Gly Ala Pro Pro Ala Lys Arg Ala Arg Ala Asp Gln Met 
65                  70                  75                  80  


Glu Val Asp Ser Gly Pro Arg Lys Arg Pro Phe Arg Gly Glu Phe Thr 
                85                  90                  95      


Asp Lys Glu Arg Arg Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys 
            100                 105                 110         


Arg Lys Gln Leu Ser Ser Gly Gly Lys Ser Leu Ser Lys Glu Glu Glu 
        115                 120                 125             


Glu Glu Leu Arg Lys Leu Thr Glu Glu Asp Glu Arg Arg Glu Arg Arg 
    130                 135                 140                 


Val Ala Gly Pro Arg Val Gly Gly Val Asn Pro Leu Glu Gly Gly Thr 
145                 150                 155                 160 


Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Ser Met Gln Gly Val Pro 
                165                 170                 175     


Glu Ser Pro Phe Ala Arg Thr Gly Glu Gly Leu Asp Val Arg Gly Asn 
            180                 185                 190         


Gln Gly Phe Pro Trp Asp Ile Leu Phe Pro Ala Asp Pro Pro Phe Ser 
        195                 200                 205             


Pro Gln Ser Cys Arg Pro Gln Ser Arg Ser Glu Ser Lys Lys Asn Arg 
    210                 215                 220                 


Gly Gly Arg Glu Glu Val Leu Glu Gln Trp Val Asn Gly Arg Lys Lys 
225                 230                 235                 240 


Leu Glu Glu Leu Glu Arg Glu Leu Arg Arg Ala Arg Lys Lys Ile Lys 
                245                 250                 255     


Lys Leu Glu Asp Asp Asn Pro Trp Leu Gly Asn Val Lys Gly Ile Leu 
            260                 265                 270         


Gly Lys Lys Asp Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Ala 
        275                 280                 285             


Arg Thr Asp Gln Met Glu Ile Asp Ser Gly Pro Arg Lys Arg Pro Leu 
    290                 295                 300                 


Arg Gly Gly Phe Thr Asp Arg Glu Arg Gln Asp His Arg Arg Arg Lys 
305                 310                 315                 320 


Ala Leu Lys Asn Lys Lys Lys Gln Leu Ser Ala Gly Gly Lys Ser Leu 
                325                 330                 335     


Ser Lys Glu Glu Glu Glu Glu Leu Lys Arg Leu Thr Arg Glu Asp Glu 
            340                 345                 350         


Glu Arg Lys Lys Glu Glu His Gly Pro Ser Arg Leu Gly Val Asn Pro 
        355                 360                 365             


Ser Glu Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Ser 
    370                 375                 380                 


Met Gln Gly Ile Pro Glu Ser Arg Phe Thr Arg Thr Gly Glu Gly Leu 
385                 390                 395                 400 


Asp Val Arg Gly Ser Arg Gly Phe Pro Gln Asp Ile Leu Phe Pro Ser 
                405                 410                 415     


Asp Pro Pro Phe Ser Pro Gln Ser Cys Arg Pro Gln Gly Thr Asn Leu 
            420                 425                 430         


Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro 
        435                 440                 445             


Ala Phe Arg Ala Asn Ser Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn 
    450                 455                 460                 


Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly Gly Gln Asn Leu Ser 
465                 470                 475                 480 


Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala 
                485                 490                 495     


Phe Arg Ala Asn Thr Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys 
            500                 505                 510         


Asp Thr Trp Pro Asp Ala Asn Lys Val Gly Gly Ser Gly Ala Thr Asn 
        515                 520                 525             


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
    530                 535                 540                 


Met Ser Gln Ser Glu Thr Arg Arg Gly Arg Arg Gly Thr Arg Glu Glu 
545                 550                 555                 560 


Thr Leu Glu Lys Trp Ile Thr Ala Arg Lys Lys Ala Glu Glu Leu Glu 
                565                 570                 575     


Lys Asp Leu Arg Lys Thr Arg Lys Thr Ile Lys Lys Leu Glu Glu Glu 
            580                 585                 590         


Asn Pro Trp Leu Gly Asn Ile Val Gly Ile Ile Arg Lys Gly Lys Asp 
        595                 600                 605             


Gly Glu Gly Ala Pro Pro Ala Lys Arg Pro Arg Thr Asp Gln Met Glu 
    610                 615                 620                 


Val Asp Ser Gly Pro Gly Lys Arg Pro His Lys Ser Gly Phe Thr Asp 
625                 630                 635                 640 


Lys Glu Arg Glu Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys Lys 
                645                 650                 655     


Lys Gln Leu Ser Ala Gly Gly Lys Ile Leu Ser Lys Glu Glu Glu Glu 
            660                 665                 670         


Glu Leu Arg Arg Leu Thr Asp Glu Asp Glu Glu Arg Lys Arg Arg Val 
        675                 680                 685             


Ala Gly Pro Arg Val Gly Asp Val Asn Pro Ser Arg Gly Gly Pro Arg 
    690                 695                 700                 


Gly Ala Pro Gly Gly Gly Phe Val Pro Gln Met Ala Gly Val Pro Glu 
705                 710                 715                 720 


Ser Pro Phe Ser Arg Thr Gly Glu Gly Leu Asp Ile Arg Gly Thr Gln 
                725                 730                 735     


Gly Phe Pro Trp Val Ser Pro Ser Pro Pro Gln Gln Arg Leu Pro Leu 
            740                 745                 750         


Leu Glu Cys Thr Pro Gln Ser Gln Ser Glu Ser Lys Lys Asn Arg Arg 
        755                 760                 765             


Gly Gly Arg Glu Asp Ile Leu Glu Lys Trp Ile Thr Thr Arg Arg Lys 
    770                 775                 780                 


Ala Glu Glu Leu Glu Lys Asp Leu Arg Lys Ala Arg Lys Thr Ile Lys 
785                 790                 795                 800 


Lys Leu Glu Asp Glu Asn Pro Trp Leu Gly Asn Ile Ile Gly Ile Ile 
                805                 810                 815     


Arg Lys Gly Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Pro Arg 
            820                 825                 830         


Thr Asp Gln Met Glu Ile Asp Ser Gly Thr Gly Lys Arg Pro His Lys 
        835                 840                 845             


Ser Gly Phe Thr Asp Lys Glu Arg Glu Asp His Arg Arg Arg Lys Ala 
    850                 855                 860                 


Leu Glu Asn Lys Lys Lys Gln Leu Ser Ser Gly Gly Lys Asn Leu Ser 
865                 870                 875                 880 


Arg Glu Glu Glu Glu Glu Leu Gly Arg Leu Thr Val Glu Asp Glu Glu 
                885                 890                 895     


Arg Arg Arg Arg Val Ala Gly Pro Arg Thr Gly Asp Val Asn Leu Ser 
            900                 905                 910         


Gly Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Arg Met 
        915                 920                 925             


Glu Gly Val Pro Glu Ser Pro Phe Thr Arg Thr Gly Glu Gly Leu Asp 
    930                 935                 940                 


Ile Arg Gly Asn Gln Gly Phe Pro Trp Val Arg Pro Ser Pro Pro Gln 
945                 950                 955                 960 


Gln Arg Leu Pro Leu Leu Glu Cys Thr Pro Gln Gly Thr Asn Leu Ser 
                965                 970                 975     


Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala 
            980                 985                 990         


Phe Arg Ala Asn Ser Ala Asn Pro  Asp Trp Asp Phe Asn  Pro Asn Lys 
        995                 1000                 1005             


Asp Thr  Trp Pro Asp Ala Asn  Lys Val Gly Gly Gln  Asn Leu Ser 
    1010                 1015                 1020             


Thr Ser  Asn Pro Leu Gly Phe  Phe Pro Asp His Gln  Leu Asp Pro 
    1025                 1030                 1035             


Ala Phe  Arg Ala Asn Thr Ala  Asn Pro Asp Trp Asp  Phe Asn Pro 
    1040                 1045                 1050             


Asn Lys  Asp Thr Trp Pro Asp  Ala Asn Lys Val Gly  
    1055                 1060                 1065 


<210>  26
<211>  1065
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Delta-2 polypeptide sequence

<400>  26

Met Ala Gly Thr Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro 
1               5                   10                  15      


Asp His Gln Leu Asp Pro Ala Phe Arg Ala Asn Ser Ala Asn Pro Asp 
            20                  25                  30          


Trp Asp Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val 
        35                  40                  45              


Gly Gly Gln Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp 
    50                  55                  60                  


His Gln Leu Asp Pro Ala Phe Arg Ala Asn Thr Ala Asn Pro Asp Trp 
65                  70                  75                  80  


Asp Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly 
                85                  90                  95      


Ser Arg Ser Glu Ser Lys Lys Asn Arg Gly Gly Arg Glu Glu Ile Leu 
            100                 105                 110         


Glu Gln Trp Val Gly Ala Arg Lys Lys Leu Glu Glu Leu Glu Arg Asp 
        115                 120                 125             


Leu Arg Lys Ile Lys Lys Lys Ile Lys Lys Leu Glu Glu Glu Asn Pro 
    130                 135                 140                 


Trp Leu Gly Asn Ile Lys Gly Ile Leu Gly Lys Lys Asp Arg Glu Gly 
145                 150                 155                 160 


Glu Gly Ala Pro Pro Ala Lys Arg Ala Arg Ala Asp Gln Met Glu Val 
                165                 170                 175     


Asp Ser Gly Pro Arg Lys Arg Pro Phe Arg Gly Glu Phe Thr Asp Lys 
            180                 185                 190         


Glu Arg Arg Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys Arg Lys 
        195                 200                 205             


Gln Leu Ser Ser Gly Gly Lys Ser Leu Ser Lys Glu Glu Glu Glu Glu 
    210                 215                 220                 


Leu Arg Lys Leu Thr Glu Glu Asp Glu Arg Arg Glu Arg Arg Val Ala 
225                 230                 235                 240 


Gly Pro Arg Val Gly Gly Val Asn Pro Leu Glu Gly Gly Thr Arg Gly 
                245                 250                 255     


Ala Pro Gly Gly Gly Phe Val Pro Ser Met Gln Gly Val Pro Glu Ser 
            260                 265                 270         


Pro Phe Ala Arg Thr Gly Glu Gly Leu Asp Val Arg Gly Asn Gln Gly 
        275                 280                 285             


Phe Pro Trp Asp Ile Leu Phe Pro Ala Asp Pro Pro Phe Ser Pro Gln 
    290                 295                 300                 


Ser Cys Arg Pro Gln Ser Arg Ser Glu Ser Lys Lys Asn Arg Gly Gly 
305                 310                 315                 320 


Arg Glu Glu Val Leu Glu Gln Trp Val Asn Gly Arg Lys Lys Leu Glu 
                325                 330                 335     


Glu Leu Glu Arg Glu Leu Arg Arg Ala Arg Lys Lys Ile Lys Lys Leu 
            340                 345                 350         


Glu Asp Asp Asn Pro Trp Leu Gly Asn Val Lys Gly Ile Leu Gly Lys 
        355                 360                 365             


Lys Asp Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Ala Arg Thr 
    370                 375                 380                 


Asp Gln Met Glu Ile Asp Ser Gly Pro Arg Lys Arg Pro Leu Arg Gly 
385                 390                 395                 400 


Gly Phe Thr Asp Arg Glu Arg Gln Asp His Arg Arg Arg Lys Ala Leu 
                405                 410                 415     


Lys Asn Lys Lys Lys Gln Leu Ser Ala Gly Gly Lys Ser Leu Ser Lys 
            420                 425                 430         


Glu Glu Glu Glu Glu Leu Lys Arg Leu Thr Arg Glu Asp Glu Glu Arg 
        435                 440                 445             


Lys Lys Glu Glu His Gly Pro Ser Arg Leu Gly Val Asn Pro Ser Glu 
    450                 455                 460                 


Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Ser Met Gln 
465                 470                 475                 480 


Gly Ile Pro Glu Ser Arg Phe Thr Arg Thr Gly Glu Gly Leu Asp Val 
                485                 490                 495     


Arg Gly Ser Arg Gly Phe Pro Gln Asp Ile Leu Phe Pro Ser Asp Pro 
            500                 505                 510         


Pro Phe Ser Pro Gln Ser Cys Arg Pro Gln Gly Ser Gly Ala Thr Asn 
        515                 520                 525             


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
    530                 535                 540                 


Met Gly Thr Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp 
545                 550                 555                 560 


His Gln Leu Asp Pro Ala Phe Arg Ala Asn Ser Ala Asn Pro Asp Trp 
                565                 570                 575     


Asp Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly 
            580                 585                 590         


Gly Gln Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His 
        595                 600                 605             


Gln Leu Asp Pro Ala Phe Arg Ala Asn Thr Ala Asn Pro Asp Trp Asp 
    610                 615                 620                 


Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly Ser 
625                 630                 635                 640 


Gln Ser Glu Thr Arg Arg Gly Arg Arg Gly Thr Arg Glu Glu Thr Leu 
                645                 650                 655     


Glu Lys Trp Ile Thr Ala Arg Lys Lys Ala Glu Glu Leu Glu Lys Asp 
            660                 665                 670         


Leu Arg Lys Thr Arg Lys Thr Ile Lys Lys Leu Glu Glu Glu Asn Pro 
        675                 680                 685             


Trp Leu Gly Asn Ile Val Gly Ile Ile Arg Lys Gly Lys Asp Gly Glu 
    690                 695                 700                 


Gly Ala Pro Pro Ala Lys Arg Pro Arg Thr Asp Gln Met Glu Val Asp 
705                 710                 715                 720 


Ser Gly Pro Gly Lys Arg Pro His Lys Ser Gly Phe Thr Asp Lys Glu 
                725                 730                 735     


Arg Glu Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys Lys Lys Gln 
            740                 745                 750         


Leu Ser Ala Gly Gly Lys Ile Leu Ser Lys Glu Glu Glu Glu Glu Leu 
        755                 760                 765             


Arg Arg Leu Thr Asp Glu Asp Glu Glu Arg Lys Arg Arg Val Ala Gly 
    770                 775                 780                 


Pro Arg Val Gly Asp Val Asn Pro Ser Arg Gly Gly Pro Arg Gly Ala 
785                 790                 795                 800 


Pro Gly Gly Gly Phe Val Pro Gln Met Ala Gly Val Pro Glu Ser Pro 
                805                 810                 815     


Phe Ser Arg Thr Gly Glu Gly Leu Asp Ile Arg Gly Thr Gln Gly Phe 
            820                 825                 830         


Pro Trp Val Ser Pro Ser Pro Pro Gln Gln Arg Leu Pro Leu Leu Glu 
        835                 840                 845             


Cys Thr Pro Gln Ser Gln Ser Glu Ser Lys Lys Asn Arg Arg Gly Gly 
    850                 855                 860                 


Arg Glu Asp Ile Leu Glu Lys Trp Ile Thr Thr Arg Arg Lys Ala Glu 
865                 870                 875                 880 


Glu Leu Glu Lys Asp Leu Arg Lys Ala Arg Lys Thr Ile Lys Lys Leu 
                885                 890                 895     


Glu Asp Glu Asn Pro Trp Leu Gly Asn Ile Ile Gly Ile Ile Arg Lys 
            900                 905                 910         


Gly Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Pro Arg Thr Asp 
        915                 920                 925             


Gln Met Glu Ile Asp Ser Gly Thr Gly Lys Arg Pro His Lys Ser Gly 
    930                 935                 940                 


Phe Thr Asp Lys Glu Arg Glu Asp His Arg Arg Arg Lys Ala Leu Glu 
945                 950                 955                 960 


Asn Lys Lys Lys Gln Leu Ser Ser Gly Gly Lys Asn Leu Ser Arg Glu 
                965                 970                 975     


Glu Glu Glu Glu Leu Gly Arg Leu Thr Val Glu Asp Glu Glu Arg Arg 
            980                 985                 990         


Arg Arg Val Ala Gly Pro Arg Thr  Gly Asp Val Asn Leu  Ser Gly Gly 
        995                 1000                 1005             


Gly Pro  Arg Gly Ala Pro Gly  Gly Gly Phe Val Pro  Arg Met Glu 
    1010                 1015                 1020             


Gly Val  Pro Glu Ser Pro Phe  Thr Arg Thr Gly Glu  Gly Leu Asp 
    1025                 1030                 1035             


Ile Arg  Gly Asn Gln Gly Phe  Pro Trp Val Arg Pro  Ser Pro Pro 
    1040                 1045                 1050             


Gln Gln  Arg Leu Pro Leu Leu  Glu Cys Thr Pro Gln  
    1055                 1060                 1065 


<210>  27
<211>  1253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Delta-3 polypeptide sequence

<400>  27

Met Ala Gly Thr Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro 
1               5                   10                  15      


Asp His Gln Leu Asp Pro Ala Phe Arg Ala Asn Ser Ala Asn Pro Asp 
            20                  25                  30          


Trp Asp Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val 
        35                  40                  45              


Gly Gly Gln Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp 
    50                  55                  60                  


His Gln Leu Asp Pro Ala Phe Arg Ala Asn Thr Ala Asn Pro Asp Trp 
65                  70                  75                  80  


Asp Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly 
                85                  90                  95      


Ser Arg Ser Glu Ser Lys Lys Asn Arg Gly Gly Arg Glu Glu Ile Leu 
            100                 105                 110         


Glu Gln Trp Val Gly Ala Arg Lys Lys Leu Glu Glu Leu Glu Arg Asp 
        115                 120                 125             


Leu Arg Lys Ile Lys Lys Lys Ile Lys Lys Leu Glu Glu Glu Asn Pro 
    130                 135                 140                 


Trp Leu Gly Asn Ile Lys Gly Ile Leu Gly Lys Lys Asp Arg Glu Gly 
145                 150                 155                 160 


Glu Gly Ala Pro Pro Ala Lys Arg Ala Arg Ala Asp Gln Met Glu Val 
                165                 170                 175     


Asp Ser Gly Pro Arg Lys Arg Pro Phe Arg Gly Glu Phe Thr Asp Lys 
            180                 185                 190         


Glu Arg Arg Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys Arg Lys 
        195                 200                 205             


Gln Leu Ser Ser Gly Gly Lys Ser Leu Ser Lys Glu Glu Glu Glu Glu 
    210                 215                 220                 


Leu Arg Lys Leu Thr Glu Glu Asp Glu Arg Arg Glu Arg Arg Val Ala 
225                 230                 235                 240 


Gly Pro Arg Val Gly Gly Val Asn Pro Leu Glu Gly Gly Thr Arg Gly 
                245                 250                 255     


Ala Pro Gly Gly Gly Phe Val Pro Ser Met Gln Gly Val Pro Glu Ser 
            260                 265                 270         


Pro Phe Ala Arg Thr Gly Glu Gly Leu Asp Val Arg Gly Asn Gln Gly 
        275                 280                 285             


Phe Pro Trp Asp Ile Leu Phe Pro Ala Asp Pro Pro Phe Ser Pro Gln 
    290                 295                 300                 


Ser Cys Arg Pro Gln Ser Arg Ser Glu Ser Lys Lys Asn Arg Gly Gly 
305                 310                 315                 320 


Arg Glu Glu Val Leu Glu Gln Trp Val Asn Gly Arg Lys Lys Leu Glu 
                325                 330                 335     


Glu Leu Glu Arg Glu Leu Arg Arg Ala Arg Lys Lys Ile Lys Lys Leu 
            340                 345                 350         


Glu Asp Asp Asn Pro Trp Leu Gly Asn Val Lys Gly Ile Leu Gly Lys 
        355                 360                 365             


Lys Asp Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Ala Arg Thr 
    370                 375                 380                 


Asp Gln Met Glu Ile Asp Ser Gly Pro Arg Lys Arg Pro Leu Arg Gly 
385                 390                 395                 400 


Gly Phe Thr Asp Arg Glu Arg Gln Asp His Arg Arg Arg Lys Ala Leu 
                405                 410                 415     


Lys Asn Lys Lys Lys Gln Leu Ser Ala Gly Gly Lys Ser Leu Ser Lys 
            420                 425                 430         


Glu Glu Glu Glu Glu Leu Lys Arg Leu Thr Arg Glu Asp Glu Glu Arg 
        435                 440                 445             


Lys Lys Glu Glu His Gly Pro Ser Arg Leu Gly Val Asn Pro Ser Glu 
    450                 455                 460                 


Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Ser Met Gln 
465                 470                 475                 480 


Gly Ile Pro Glu Ser Arg Phe Thr Arg Thr Gly Glu Gly Leu Asp Val 
                485                 490                 495     


Arg Gly Ser Arg Gly Phe Pro Gln Asp Ile Leu Phe Pro Ser Asp Pro 
            500                 505                 510         


Pro Phe Ser Pro Gln Ser Cys Arg Pro Gln Gly Thr Asn Leu Ser Thr 
        515                 520                 525             


Ser Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe 
    530                 535                 540                 


Arg Ala Asn Ser Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys Asp 
545                 550                 555                 560 


Thr Trp Pro Asp Ala Asn Lys Val Gly Gly Gln Asn Leu Ser Thr Ser 
                565                 570                 575     


Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Arg 
            580                 585                 590         


Ala Asn Thr Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys Asp Thr 
        595                 600                 605             


Trp Pro Asp Ala Asn Lys Val Gly Gly Ser Gly Ala Thr Asn Phe Ser 
    610                 615                 620                 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly 
625                 630                 635                 640 


Thr Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His Gln 
                645                 650                 655     


Leu Asp Pro Ala Phe Arg Ala Asn Ser Ala Asn Pro Asp Trp Asp Phe 
            660                 665                 670         


Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly Gly Gln 
        675                 680                 685             


Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu 
    690                 695                 700                 


Asp Pro Ala Phe Arg Ala Asn Thr Ala Asn Pro Asp Trp Asp Phe Asn 
705                 710                 715                 720 


Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly Ser Gln Ser 
                725                 730                 735     


Glu Thr Arg Arg Gly Arg Arg Gly Thr Arg Glu Glu Thr Leu Glu Lys 
            740                 745                 750         


Trp Ile Thr Ala Arg Lys Lys Ala Glu Glu Leu Glu Lys Asp Leu Arg 
        755                 760                 765             


Lys Thr Arg Lys Thr Ile Lys Lys Leu Glu Glu Glu Asn Pro Trp Leu 
    770                 775                 780                 


Gly Asn Ile Val Gly Ile Ile Arg Lys Gly Lys Asp Gly Glu Gly Ala 
785                 790                 795                 800 


Pro Pro Ala Lys Arg Pro Arg Thr Asp Gln Met Glu Val Asp Ser Gly 
                805                 810                 815     


Pro Gly Lys Arg Pro His Lys Ser Gly Phe Thr Asp Lys Glu Arg Glu 
            820                 825                 830         


Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys Lys Lys Gln Leu Ser 
        835                 840                 845             


Ala Gly Gly Lys Ile Leu Ser Lys Glu Glu Glu Glu Glu Leu Arg Arg 
    850                 855                 860                 


Leu Thr Asp Glu Asp Glu Glu Arg Lys Arg Arg Val Ala Gly Pro Arg 
865                 870                 875                 880 


Val Gly Asp Val Asn Pro Ser Arg Gly Gly Pro Arg Gly Ala Pro Gly 
                885                 890                 895     


Gly Gly Phe Val Pro Gln Met Ala Gly Val Pro Glu Ser Pro Phe Ser 
            900                 905                 910         


Arg Thr Gly Glu Gly Leu Asp Ile Arg Gly Thr Gln Gly Phe Pro Trp 
        915                 920                 925             


Val Ser Pro Ser Pro Pro Gln Gln Arg Leu Pro Leu Leu Glu Cys Thr 
    930                 935                 940                 


Pro Gln Ser Gln Ser Glu Ser Lys Lys Asn Arg Arg Gly Gly Arg Glu 
945                 950                 955                 960 


Asp Ile Leu Glu Lys Trp Ile Thr Thr Arg Arg Lys Ala Glu Glu Leu 
                965                 970                 975     


Glu Lys Asp Leu Arg Lys Ala Arg Lys Thr Ile Lys Lys Leu Glu Asp 
            980                 985                 990         


Glu Asn Pro Trp Leu Gly Asn Ile  Ile Gly Ile Ile Arg  Lys Gly Lys 
        995                 1000                 1005             


Asp Gly  Glu Gly Ala Pro Pro  Ala Lys Arg Pro Arg  Thr Asp Gln 
    1010                 1015                 1020             


Met Glu  Ile Asp Ser Gly Thr  Gly Lys Arg Pro His  Lys Ser Gly 
    1025                 1030                 1035             


Phe Thr  Asp Lys Glu Arg Glu  Asp His Arg Arg Arg  Lys Ala Leu 
    1040                 1045                 1050             


Glu Asn  Lys Lys Lys Gln Leu  Ser Ser Gly Gly Lys  Asn Leu Ser 
    1055                 1060                 1065             


Arg Glu  Glu Glu Glu Glu Leu  Gly Arg Leu Thr Val  Glu Asp Glu 
    1070                 1075                 1080             


Glu Arg  Arg Arg Arg Val Ala  Gly Pro Arg Thr Gly  Asp Val Asn 
    1085                 1090                 1095             


Leu Ser  Gly Gly Gly Pro Arg  Gly Ala Pro Gly Gly  Gly Phe Val 
    1100                 1105                 1110             


Pro Arg  Met Glu Gly Val Pro  Glu Ser Pro Phe Thr  Arg Thr Gly 
    1115                 1120                 1125             


Glu Gly  Leu Asp Ile Arg Gly  Asn Gln Gly Phe Pro  Trp Val Arg 
    1130                 1135                 1140             


Pro Ser  Pro Pro Gln Gln Arg  Leu Pro Leu Leu Glu  Cys Thr Pro 
    1145                 1150                 1155             


Gln Gly  Thr Asn Leu Ser Thr  Ser Asn Pro Leu Gly  Phe Phe Pro 
    1160                 1165                 1170             


Asp His  Gln Leu Asp Pro Ala  Phe Arg Ala Asn Ser  Ala Asn Pro 
    1175                 1180                 1185             


Asp Trp  Asp Phe Asn Pro Asn  Lys Asp Thr Trp Pro  Asp Ala Asn 
    1190                 1195                 1200             


Lys Val  Gly Gly Gln Asn Leu  Ser Thr Ser Asn Pro  Leu Gly Phe 
    1205                 1210                 1215             


Phe Pro  Asp His Gln Leu Asp  Pro Ala Phe Arg Ala  Asn Thr Ala 
    1220                 1225                 1230             


Asn Pro  Asp Trp Asp Phe Asn  Pro Asn Lys Asp Thr  Trp Pro Asp 
    1235                 1240                 1245             


Ala Asn  Lys Val Gly 
    1250             


<210>  28
<211>  1299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Delta-4 polypeptide sequence

<400>  28

Met Ala Ser Arg Ser Glu Ser Lys Lys Asn Arg Gly Gly Arg Glu Glu 
1               5                   10                  15      


Ile Leu Glu Gln Trp Val Gly Ala Arg Lys Lys Leu Glu Glu Leu Glu 
            20                  25                  30          


Arg Asp Leu Arg Lys Ile Lys Lys Lys Ile Lys Lys Leu Glu Glu Glu 
        35                  40                  45              


Asn Pro Trp Leu Gly Asn Ile Lys Gly Ile Leu Gly Lys Lys Asp Arg 
    50                  55                  60                  


Glu Gly Glu Gly Ala Pro Pro Ala Lys Arg Ala Arg Ala Asp Gln Met 
65                  70                  75                  80  


Glu Val Asp Ser Gly Pro Arg Lys Arg Pro Phe Arg Gly Glu Phe Thr 
                85                  90                  95      


Asp Lys Glu Arg Arg Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys 
            100                 105                 110         


Arg Lys Gln Leu Ser Ser Gly Gly Lys Ser Leu Ser Lys Glu Glu Glu 
        115                 120                 125             


Glu Glu Leu Arg Lys Leu Thr Glu Glu Asp Glu Arg Arg Glu Arg Arg 
    130                 135                 140                 


Val Ala Gly Pro Arg Val Gly Gly Val Asn Pro Leu Glu Gly Gly Thr 
145                 150                 155                 160 


Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Ser Met Gln Gly Val Pro 
                165                 170                 175     


Glu Ser Pro Phe Ala Arg Thr Gly Glu Gly Leu Asp Val Arg Gly Asn 
            180                 185                 190         


Gln Gly Phe Pro Trp Asp Ile Leu Phe Pro Ala Asp Pro Pro Phe Ser 
        195                 200                 205             


Pro Gln Ser Cys Arg Pro Gln Gly Thr Asn Leu Ser Thr Ser Asn Pro 
    210                 215                 220                 


Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Arg Ala Asn 
225                 230                 235                 240 


Ser Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys Asp Thr Trp Pro 
                245                 250                 255     


Asp Ala Asn Lys Val Gly Gly Gln Asn Leu Ser Thr Ser Asn Pro Leu 
            260                 265                 270         


Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Arg Ala Asn Thr 
        275                 280                 285             


Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp 
    290                 295                 300                 


Ala Asn Lys Val Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
305                 310                 315                 320 


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ser Arg Ser Glu 
                325                 330                 335     


Ser Lys Lys Asn Arg Gly Gly Arg Glu Glu Val Leu Glu Gln Trp Val 
            340                 345                 350         


Asn Gly Arg Lys Lys Leu Glu Glu Leu Glu Arg Glu Leu Arg Arg Ala 
        355                 360                 365             


Arg Lys Lys Ile Lys Lys Leu Glu Asp Asp Asn Pro Trp Leu Gly Asn 
    370                 375                 380                 


Val Lys Gly Ile Leu Gly Lys Lys Asp Lys Asp Gly Glu Gly Ala Pro 
385                 390                 395                 400 


Pro Ala Lys Arg Ala Arg Thr Asp Gln Met Glu Ile Asp Ser Gly Pro 
                405                 410                 415     


Arg Lys Arg Pro Leu Arg Gly Gly Phe Thr Asp Arg Glu Arg Gln Asp 
            420                 425                 430         


His Arg Arg Arg Lys Ala Leu Lys Asn Lys Lys Lys Gln Leu Ser Ala 
        435                 440                 445             


Gly Gly Lys Ser Leu Ser Lys Glu Glu Glu Glu Glu Leu Lys Arg Leu 
    450                 455                 460                 


Thr Arg Glu Asp Glu Glu Arg Lys Lys Glu Glu His Gly Pro Ser Arg 
465                 470                 475                 480 


Leu Gly Val Asn Pro Ser Glu Gly Gly Pro Arg Gly Ala Pro Gly Gly 
                485                 490                 495     


Gly Phe Val Pro Ser Met Gln Gly Ile Pro Glu Ser Arg Phe Thr Arg 
            500                 505                 510         


Thr Gly Glu Gly Leu Asp Val Arg Gly Ser Arg Gly Phe Pro Gln Asp 
        515                 520                 525             


Ile Leu Phe Pro Ser Asp Pro Pro Phe Ser Pro Gln Ser Cys Arg Pro 
    530                 535                 540                 


Gln Gly Thr Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp 
545                 550                 555                 560 


His Gln Leu Asp Pro Ala Phe Arg Ala Asn Ser Ala Asn Pro Asp Trp 
                565                 570                 575     


Asp Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly 
            580                 585                 590         


Gly Gln Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His 
        595                 600                 605             


Gln Leu Asp Pro Ala Phe Arg Ala Asn Thr Ala Asn Pro Asp Trp Asp 
    610                 615                 620                 


Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly Gly 
625                 630                 635                 640 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                645                 650                 655     


Glu Asn Pro Gly Pro Met Ser Gln Ser Glu Thr Arg Arg Gly Arg Arg 
            660                 665                 670         


Gly Thr Arg Glu Glu Thr Leu Glu Lys Trp Ile Thr Ala Arg Lys Lys 
        675                 680                 685             


Ala Glu Glu Leu Glu Lys Asp Leu Arg Lys Thr Arg Lys Thr Ile Lys 
    690                 695                 700                 


Lys Leu Glu Glu Glu Asn Pro Trp Leu Gly Asn Ile Val Gly Ile Ile 
705                 710                 715                 720 


Arg Lys Gly Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Pro Arg 
                725                 730                 735     


Thr Asp Gln Met Glu Val Asp Ser Gly Pro Gly Lys Arg Pro His Lys 
            740                 745                 750         


Ser Gly Phe Thr Asp Lys Glu Arg Glu Asp His Arg Arg Arg Lys Ala 
        755                 760                 765             


Leu Glu Asn Lys Lys Lys Gln Leu Ser Ala Gly Gly Lys Ile Leu Ser 
    770                 775                 780                 


Lys Glu Glu Glu Glu Glu Leu Arg Arg Leu Thr Asp Glu Asp Glu Glu 
785                 790                 795                 800 


Arg Lys Arg Arg Val Ala Gly Pro Arg Val Gly Asp Val Asn Pro Ser 
                805                 810                 815     


Arg Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Gln Met 
            820                 825                 830         


Ala Gly Val Pro Glu Ser Pro Phe Ser Arg Thr Gly Glu Gly Leu Asp 
        835                 840                 845             


Ile Arg Gly Thr Gln Gly Phe Pro Trp Val Ser Pro Ser Pro Pro Gln 
    850                 855                 860                 


Gln Arg Leu Pro Leu Leu Glu Cys Thr Pro Gln Gly Thr Asn Leu Ser 
865                 870                 875                 880 


Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala 
                885                 890                 895     


Phe Arg Ala Asn Ser Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys 
            900                 905                 910         


Asp Thr Trp Pro Asp Ala Asn Lys Val Gly Gly Gln Asn Leu Ser Thr 
        915                 920                 925             


Ser Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe 
    930                 935                 940                 


Arg Ala Asn Thr Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys Asp 
945                 950                 955                 960 


Thr Trp Pro Asp Ala Asn Lys Val Gly Gly Ser Gly Ala Thr Asn Phe 
                965                 970                 975     


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
            980                 985                 990         


Ser Gln Ser Glu Ser Lys Lys Asn  Arg Arg Gly Gly Arg  Glu Asp Ile 
        995                 1000                 1005             


Leu Glu  Lys Trp Ile Thr Thr  Arg Arg Lys Ala Glu  Glu Leu Glu 
    1010                 1015                 1020             


Lys Asp  Leu Arg Lys Ala Arg  Lys Thr Ile Lys Lys  Leu Glu Asp 
    1025                 1030                 1035             


Glu Asn  Pro Trp Leu Gly Asn  Ile Ile Gly Ile Ile  Arg Lys Gly 
    1040                 1045                 1050             


Lys Asp  Gly Glu Gly Ala Pro  Pro Ala Lys Arg Pro  Arg Thr Asp 
    1055                 1060                 1065             


Gln Met  Glu Ile Asp Ser Gly  Thr Gly Lys Arg Pro  His Lys Ser 
    1070                 1075                 1080             


Gly Phe  Thr Asp Lys Glu Arg  Glu Asp His Arg Arg  Arg Lys Ala 
    1085                 1090                 1095             


Leu Glu  Asn Lys Lys Lys Gln  Leu Ser Ser Gly Gly  Lys Asn Leu 
    1100                 1105                 1110             


Ser Arg  Glu Glu Glu Glu Glu  Leu Gly Arg Leu Thr  Val Glu Asp 
    1115                 1120                 1125             


Glu Glu  Arg Arg Arg Arg Val  Ala Gly Pro Arg Thr  Gly Asp Val 
    1130                 1135                 1140             


Asn Leu  Ser Gly Gly Gly Pro  Arg Gly Ala Pro Gly  Gly Gly Phe 
    1145                 1150                 1155             


Val Pro  Arg Met Glu Gly Val  Pro Glu Ser Pro Phe  Thr Arg Thr 
    1160                 1165                 1170             


Gly Glu  Gly Leu Asp Ile Arg  Gly Asn Gln Gly Phe  Pro Trp Val 
    1175                 1180                 1185             


Arg Pro  Ser Pro Pro Gln Gln  Arg Leu Pro Leu Leu  Glu Cys Thr 
    1190                 1195                 1200             


Pro Gln  Gly Thr Asn Leu Ser  Thr Ser Asn Pro Leu  Gly Phe Phe 
    1205                 1210                 1215             


Pro Asp  His Gln Leu Asp Pro  Ala Phe Arg Ala Asn  Ser Ala Asn 
    1220                 1225                 1230             


Pro Asp  Trp Asp Phe Asn Pro  Asn Lys Asp Thr Trp  Pro Asp Ala 
    1235                 1240                 1245             


Asn Lys  Val Gly Gly Gln Asn  Leu Ser Thr Ser Asn  Pro Leu Gly 
    1250                 1255                 1260             


Phe Phe  Pro Asp His Gln Leu  Asp Pro Ala Phe Arg  Ala Asn Thr 
    1265                 1270                 1275             


Ala Asn  Pro Asp Trp Asp Phe  Asn Pro Asn Lys Asp  Thr Trp Pro 
    1280                 1285                 1290             


Asp Ala  Asn Lys Val Gly 
    1295                 


<210>  29
<211>  877
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Delta-5 polypeptide sequence

<400>  29

Met Ala Ser Arg Ser Glu Ser Lys Lys Asn Arg Gly Gly Arg Glu Glu 
1               5                   10                  15      


Ile Leu Glu Gln Trp Val Gly Ala Arg Lys Lys Leu Glu Glu Leu Glu 
            20                  25                  30          


Arg Asp Leu Arg Lys Ile Lys Lys Lys Ile Lys Lys Leu Glu Glu Glu 
        35                  40                  45              


Asn Pro Trp Leu Gly Asn Ile Lys Gly Ile Leu Gly Lys Lys Asp Arg 
    50                  55                  60                  


Glu Gly Glu Gly Ala Pro Pro Ala Lys Arg Ala Arg Ala Asp Gln Met 
65                  70                  75                  80  


Glu Val Asp Ser Gly Pro Arg Lys Arg Pro Phe Arg Gly Glu Phe Thr 
                85                  90                  95      


Asp Lys Glu Arg Arg Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys 
            100                 105                 110         


Arg Lys Gln Leu Ser Ser Gly Gly Lys Ser Leu Ser Lys Glu Glu Glu 
        115                 120                 125             


Glu Glu Leu Arg Lys Leu Thr Glu Glu Asp Glu Arg Arg Glu Arg Arg 
    130                 135                 140                 


Val Ala Gly Pro Arg Val Gly Gly Val Asn Pro Leu Glu Gly Gly Thr 
145                 150                 155                 160 


Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Ser Met Gln Gly Val Pro 
                165                 170                 175     


Glu Ser Pro Phe Ala Arg Thr Gly Glu Gly Leu Asp Val Arg Gly Asn 
            180                 185                 190         


Gln Gly Phe Pro Trp Asp Ile Leu Phe Pro Ala Asp Pro Pro Phe Ser 
        195                 200                 205             


Pro Gln Ser Cys Arg Pro Gln Ser Arg Ser Glu Ser Lys Lys Asn Arg 
    210                 215                 220                 


Gly Gly Arg Glu Glu Val Leu Glu Gln Trp Val Asn Gly Arg Lys Lys 
225                 230                 235                 240 


Leu Glu Glu Leu Glu Arg Glu Leu Arg Arg Ala Arg Lys Lys Ile Lys 
                245                 250                 255     


Lys Leu Glu Asp Asp Asn Pro Trp Leu Gly Asn Val Lys Gly Ile Leu 
            260                 265                 270         


Gly Lys Lys Asp Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Ala 
        275                 280                 285             


Arg Thr Asp Gln Met Glu Ile Asp Ser Gly Pro Arg Lys Arg Pro Leu 
    290                 295                 300                 


Arg Gly Gly Phe Thr Asp Arg Glu Arg Gln Asp His Arg Arg Arg Lys 
305                 310                 315                 320 


Ala Leu Lys Asn Lys Lys Lys Gln Leu Ser Ala Gly Gly Lys Ser Leu 
                325                 330                 335     


Ser Lys Glu Glu Glu Glu Glu Leu Lys Arg Leu Thr Arg Glu Asp Glu 
            340                 345                 350         


Glu Arg Lys Lys Glu Glu His Gly Pro Ser Arg Leu Gly Val Asn Pro 
        355                 360                 365             


Ser Glu Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Ser 
    370                 375                 380                 


Met Gln Gly Ile Pro Glu Ser Arg Phe Thr Arg Thr Gly Glu Gly Leu 
385                 390                 395                 400 


Asp Val Arg Gly Ser Arg Gly Phe Pro Gln Asp Ile Leu Phe Pro Ser 
                405                 410                 415     


Asp Pro Pro Phe Ser Pro Gln Ser Cys Arg Pro Gln Gly Ser Gly Ala 
            420                 425                 430         


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
        435                 440                 445             


Gly Pro Met Ser Gln Ser Glu Thr Arg Arg Gly Arg Arg Gly Thr Arg 
    450                 455                 460                 


Glu Glu Thr Leu Glu Lys Trp Ile Thr Ala Arg Lys Lys Ala Glu Glu 
465                 470                 475                 480 


Leu Glu Lys Asp Leu Arg Lys Thr Arg Lys Thr Ile Lys Lys Leu Glu 
                485                 490                 495     


Glu Glu Asn Pro Trp Leu Gly Asn Ile Val Gly Ile Ile Arg Lys Gly 
            500                 505                 510         


Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Pro Arg Thr Asp Gln 
        515                 520                 525             


Met Glu Val Asp Ser Gly Pro Gly Lys Arg Pro His Lys Ser Gly Phe 
    530                 535                 540                 


Thr Asp Lys Glu Arg Glu Asp His Arg Arg Arg Lys Ala Leu Glu Asn 
545                 550                 555                 560 


Lys Lys Lys Gln Leu Ser Ala Gly Gly Lys Ile Leu Ser Lys Glu Glu 
                565                 570                 575     


Glu Glu Glu Leu Arg Arg Leu Thr Asp Glu Asp Glu Glu Arg Lys Arg 
            580                 585                 590         


Arg Val Ala Gly Pro Arg Val Gly Asp Val Asn Pro Ser Arg Gly Gly 
        595                 600                 605             


Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Gln Met Ala Gly Val 
    610                 615                 620                 


Pro Glu Ser Pro Phe Ser Arg Thr Gly Glu Gly Leu Asp Ile Arg Gly 
625                 630                 635                 640 


Thr Gln Gly Phe Pro Trp Val Ser Pro Ser Pro Pro Gln Gln Arg Leu 
                645                 650                 655     


Pro Leu Leu Glu Cys Thr Pro Gln Ser Gln Ser Glu Ser Lys Lys Asn 
            660                 665                 670         


Arg Arg Gly Gly Arg Glu Asp Ile Leu Glu Lys Trp Ile Thr Thr Arg 
        675                 680                 685             


Arg Lys Ala Glu Glu Leu Glu Lys Asp Leu Arg Lys Ala Arg Lys Thr 
    690                 695                 700                 


Ile Lys Lys Leu Glu Asp Glu Asn Pro Trp Leu Gly Asn Ile Ile Gly 
705                 710                 715                 720 


Ile Ile Arg Lys Gly Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg 
                725                 730                 735     


Pro Arg Thr Asp Gln Met Glu Ile Asp Ser Gly Thr Gly Lys Arg Pro 
            740                 745                 750         


His Lys Ser Gly Phe Thr Asp Lys Glu Arg Glu Asp His Arg Arg Arg 
        755                 760                 765             


Lys Ala Leu Glu Asn Lys Lys Lys Gln Leu Ser Ser Gly Gly Lys Asn 
    770                 775                 780                 


Leu Ser Arg Glu Glu Glu Glu Glu Leu Gly Arg Leu Thr Val Glu Asp 
785                 790                 795                 800 


Glu Glu Arg Arg Arg Arg Val Ala Gly Pro Arg Thr Gly Asp Val Asn 
                805                 810                 815     


Leu Ser Gly Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro 
            820                 825                 830         


Arg Met Glu Gly Val Pro Glu Ser Pro Phe Thr Arg Thr Gly Glu Gly 
        835                 840                 845             


Leu Asp Ile Arg Gly Asn Gln Gly Phe Pro Trp Val Arg Pro Ser Pro 
    850                 855                 860                 


Pro Gln Gln Arg Leu Pro Leu Leu Glu Cys Thr Pro Gln 
865                 870                 875         


<210>  30
<211>  923
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Delta-6 polypeptide sequence

<400>  30

Met Ala Ser Arg Ser Glu Ser Lys Lys Asn Arg Gly Gly Arg Glu Glu 
1               5                   10                  15      


Ile Leu Glu Gln Trp Val Gly Ala Arg Lys Lys Leu Glu Glu Leu Glu 
            20                  25                  30          


Arg Asp Leu Arg Lys Ile Lys Lys Lys Ile Lys Lys Leu Glu Glu Glu 
        35                  40                  45              


Asn Pro Trp Leu Gly Asn Ile Lys Gly Ile Leu Gly Lys Lys Asp Arg 
    50                  55                  60                  


Glu Gly Glu Gly Ala Pro Pro Ala Lys Arg Ala Arg Ala Asp Gln Met 
65                  70                  75                  80  


Glu Val Asp Ser Gly Pro Arg Lys Arg Pro Phe Arg Gly Glu Phe Thr 
                85                  90                  95      


Asp Lys Glu Arg Arg Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys 
            100                 105                 110         


Arg Lys Gln Leu Ser Ser Gly Gly Lys Ser Leu Ser Lys Glu Glu Glu 
        115                 120                 125             


Glu Glu Leu Arg Lys Leu Thr Glu Glu Asp Glu Arg Arg Glu Arg Arg 
    130                 135                 140                 


Val Ala Gly Pro Arg Val Gly Gly Val Asn Pro Leu Glu Gly Gly Thr 
145                 150                 155                 160 


Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Ser Met Gln Gly Val Pro 
                165                 170                 175     


Glu Ser Pro Phe Ala Arg Thr Gly Glu Gly Leu Asp Val Arg Gly Asn 
            180                 185                 190         


Gln Gly Phe Pro Trp Asp Ile Leu Phe Pro Ala Asp Pro Pro Phe Ser 
        195                 200                 205             


Pro Gln Ser Cys Arg Pro Gln Gly Ser Gly Ala Thr Asn Phe Ser Leu 
    210                 215                 220                 


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ser Arg 
225                 230                 235                 240 


Ser Glu Ser Lys Lys Asn Arg Gly Gly Arg Glu Glu Val Leu Glu Gln 
                245                 250                 255     


Trp Val Asn Gly Arg Lys Lys Leu Glu Glu Leu Glu Arg Glu Leu Arg 
            260                 265                 270         


Arg Ala Arg Lys Lys Ile Lys Lys Leu Glu Asp Asp Asn Pro Trp Leu 
        275                 280                 285             


Gly Asn Val Lys Gly Ile Leu Gly Lys Lys Asp Lys Asp Gly Glu Gly 
    290                 295                 300                 


Ala Pro Pro Ala Lys Arg Ala Arg Thr Asp Gln Met Glu Ile Asp Ser 
305                 310                 315                 320 


Gly Pro Arg Lys Arg Pro Leu Arg Gly Gly Phe Thr Asp Arg Glu Arg 
                325                 330                 335     


Gln Asp His Arg Arg Arg Lys Ala Leu Lys Asn Lys Lys Lys Gln Leu 
            340                 345                 350         


Ser Ala Gly Gly Lys Ser Leu Ser Lys Glu Glu Glu Glu Glu Leu Lys 
        355                 360                 365             


Arg Leu Thr Arg Glu Asp Glu Glu Arg Lys Lys Glu Glu His Gly Pro 
    370                 375                 380                 


Ser Arg Leu Gly Val Asn Pro Ser Glu Gly Gly Pro Arg Gly Ala Pro 
385                 390                 395                 400 


Gly Gly Gly Phe Val Pro Ser Met Gln Gly Ile Pro Glu Ser Arg Phe 
                405                 410                 415     


Thr Arg Thr Gly Glu Gly Leu Asp Val Arg Gly Ser Arg Gly Phe Pro 
            420                 425                 430         


Gln Asp Ile Leu Phe Pro Ser Asp Pro Pro Phe Ser Pro Gln Ser Cys 
        435                 440                 445             


Arg Pro Gln Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
    450                 455                 460                 


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ser Gln Ser Glu Thr Arg 
465                 470                 475                 480 


Arg Gly Arg Arg Gly Thr Arg Glu Glu Thr Leu Glu Lys Trp Ile Thr 
                485                 490                 495     


Ala Arg Lys Lys Ala Glu Glu Leu Glu Lys Asp Leu Arg Lys Thr Arg 
            500                 505                 510         


Lys Thr Ile Lys Lys Leu Glu Glu Glu Asn Pro Trp Leu Gly Asn Ile 
        515                 520                 525             


Val Gly Ile Ile Arg Lys Gly Lys Asp Gly Glu Gly Ala Pro Pro Ala 
    530                 535                 540                 


Lys Arg Pro Arg Thr Asp Gln Met Glu Val Asp Ser Gly Pro Gly Lys 
545                 550                 555                 560 


Arg Pro His Lys Ser Gly Phe Thr Asp Lys Glu Arg Glu Asp His Arg 
                565                 570                 575     


Arg Arg Lys Ala Leu Glu Asn Lys Lys Lys Gln Leu Ser Ala Gly Gly 
            580                 585                 590         


Lys Ile Leu Ser Lys Glu Glu Glu Glu Glu Leu Arg Arg Leu Thr Asp 
        595                 600                 605             


Glu Asp Glu Glu Arg Lys Arg Arg Val Ala Gly Pro Arg Val Gly Asp 
    610                 615                 620                 


Val Asn Pro Ser Arg Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe 
625                 630                 635                 640 


Val Pro Gln Met Ala Gly Val Pro Glu Ser Pro Phe Ser Arg Thr Gly 
                645                 650                 655     


Glu Gly Leu Asp Ile Arg Gly Thr Gln Gly Phe Pro Trp Val Ser Pro 
            660                 665                 670         


Ser Pro Pro Gln Gln Arg Leu Pro Leu Leu Glu Cys Thr Pro Gln Gly 
        675                 680                 685             


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
    690                 695                 700                 


Glu Asn Pro Gly Pro Met Ser Gln Ser Glu Ser Lys Lys Asn Arg Arg 
705                 710                 715                 720 


Gly Gly Arg Glu Asp Ile Leu Glu Lys Trp Ile Thr Thr Arg Arg Lys 
                725                 730                 735     


Ala Glu Glu Leu Glu Lys Asp Leu Arg Lys Ala Arg Lys Thr Ile Lys 
            740                 745                 750         


Lys Leu Glu Asp Glu Asn Pro Trp Leu Gly Asn Ile Ile Gly Ile Ile 
        755                 760                 765             


Arg Lys Gly Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Pro Arg 
    770                 775                 780                 


Thr Asp Gln Met Glu Ile Asp Ser Gly Thr Gly Lys Arg Pro His Lys 
785                 790                 795                 800 


Ser Gly Phe Thr Asp Lys Glu Arg Glu Asp His Arg Arg Arg Lys Ala 
                805                 810                 815     


Leu Glu Asn Lys Lys Lys Gln Leu Ser Ser Gly Gly Lys Asn Leu Ser 
            820                 825                 830         


Arg Glu Glu Glu Glu Glu Leu Gly Arg Leu Thr Val Glu Asp Glu Glu 
        835                 840                 845             


Arg Arg Arg Arg Val Ala Gly Pro Arg Thr Gly Asp Val Asn Leu Ser 
    850                 855                 860                 


Gly Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Arg Met 
865                 870                 875                 880 


Glu Gly Val Pro Glu Ser Pro Phe Thr Arg Thr Gly Glu Gly Leu Asp 
                885                 890                 895     


Ile Arg Gly Asn Gln Gly Phe Pro Trp Val Arg Pro Ser Pro Pro Gln 
            900                 905                 910         


Gln Arg Leu Pro Leu Leu Glu Cys Thr Pro Gln 
        915                 920             


<210>  31
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Delta-7 polypeptide sequence

<400>  31

Met Ala Ser Arg Ser Glu Ser Lys Lys Asn Arg Gly Gly Arg Glu Glu 
1               5                   10                  15      


Ile Leu Glu Gln Trp Val Gly Ala Arg Lys Lys Leu Glu Glu Leu Glu 
            20                  25                  30          


Arg Asp Leu Arg Lys Ile Lys Lys Lys Ile Lys Lys Leu Glu Glu Glu 
        35                  40                  45              


Asn Pro Trp Leu Gly Asn Ile Lys Gly Ile Leu Gly Lys Lys Asp Arg 
    50                  55                  60                  


Glu Gly Glu Gly Ala Pro Pro Ala Lys Arg Ala Arg Ala Asp Gln Met 
65                  70                  75                  80  


Glu Val Asp Ser Gly Pro Arg Lys Arg Pro Phe Arg Gly Glu Phe Thr 
                85                  90                  95      


Asp Lys Glu Arg Arg Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys 
            100                 105                 110         


Arg Lys Gln Leu Ser Ser Gly Gly Lys Ser Leu Ser Lys Glu Glu Glu 
        115                 120                 125             


Glu Glu Leu Arg Lys Leu Thr Glu Glu Asp Glu Arg Arg Glu Arg Arg 
    130                 135                 140                 


Val Ala Gly Pro Arg Val Gly Gly Val Asn Pro Leu Glu Gly Gly Thr 
145                 150                 155                 160 


Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Ser Met Gln Gly Val Pro 
                165                 170                 175     


Glu Ser Pro Phe Ala Arg Thr Gly Glu Gly Leu Asp Val Arg Gly Asn 
            180                 185                 190         


Gln Gly Phe Pro Trp Asp Ile Leu Phe Pro Ala Asp Pro Pro Phe Ser 
        195                 200                 205             


Pro Gln Ser Cys Arg Pro Gln Ser Arg Ser Glu Ser Lys Lys Asn Arg 
    210                 215                 220                 


Gly Gly Arg Glu Glu Val Leu Glu Gln Trp Val Asn Gly Arg Lys Lys 
225                 230                 235                 240 


Leu Glu Glu Leu Glu Arg Glu Leu Arg Arg Ala Arg Lys Lys Ile Lys 
                245                 250                 255     


Lys Leu Glu Asp Asp Asn Pro Trp Leu Gly Asn Val Lys Gly Ile Leu 
            260                 265                 270         


Gly Lys Lys Asp Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Ala 
        275                 280                 285             


Arg Thr Asp Gln Met Glu Ile Asp Ser Gly Pro Arg Lys Arg Pro Leu 
    290                 295                 300                 


Arg Gly Gly Phe Thr Asp Arg Glu Arg Gln Asp His Arg Arg Arg Lys 
305                 310                 315                 320 


Ala Leu Lys Asn Lys Lys Lys Gln Leu Ser Ala Gly Gly Lys Ser Leu 
                325                 330                 335     


Ser Lys Glu Glu Glu Glu Glu Leu Lys Arg Leu Thr Arg Glu Asp Glu 
            340                 345                 350         


Glu Arg Lys Lys Glu Glu His Gly Pro Ser Arg Leu Gly Val Asn Pro 
        355                 360                 365             


Ser Glu Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Ser 
    370                 375                 380                 


Met Gln Gly Ile Pro Glu Ser Arg Phe Thr Arg Thr Gly Glu Gly Leu 
385                 390                 395                 400 


Asp Val Arg Gly Ser Arg Gly Phe Pro Gln Asp Ile Leu Phe Pro Ser 
                405                 410                 415     


Asp Pro Pro Phe Ser Pro Gln Ser Cys Arg Pro Gln Gly Thr Asn Leu 
            420                 425                 430         


Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro 
        435                 440                 445             


Ala Phe Arg Ala Asn Ser Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn 
    450                 455                 460                 


Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly Gly Gln Asn Leu Ser 
465                 470                 475                 480 


Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala 
                485                 490                 495     


Phe Arg Ala Asn Thr Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys 
            500                 505                 510         


Asp Thr Trp Pro Asp Ala Asn Lys Val Gly 
        515                 520         


<210>  32
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Delta-8 polypeptide sequence

<400>  32

Met Ala Ser Gln Ser Glu Thr Arg Arg Gly Arg Arg Gly Thr Arg Glu 
1               5                   10                  15      


Glu Thr Leu Glu Lys Trp Ile Thr Ala Arg Lys Lys Ala Glu Glu Leu 
            20                  25                  30          


Glu Lys Asp Leu Arg Lys Thr Arg Lys Thr Ile Lys Lys Leu Glu Glu 
        35                  40                  45              


Glu Asn Pro Trp Leu Gly Asn Ile Val Gly Ile Ile Arg Lys Gly Lys 
    50                  55                  60                  


Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Pro Arg Thr Asp Gln Met 
65                  70                  75                  80  


Glu Val Asp Ser Gly Pro Gly Lys Arg Pro His Lys Ser Gly Phe Thr 
                85                  90                  95      


Asp Lys Glu Arg Glu Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys 
            100                 105                 110         


Lys Lys Gln Leu Ser Ala Gly Gly Lys Ile Leu Ser Lys Glu Glu Glu 
        115                 120                 125             


Glu Glu Leu Arg Arg Leu Thr Asp Glu Asp Glu Glu Arg Lys Arg Arg 
    130                 135                 140                 


Val Ala Gly Pro Arg Val Gly Asp Val Asn Pro Ser Arg Gly Gly Pro 
145                 150                 155                 160 


Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Gln Met Ala Gly Val Pro 
                165                 170                 175     


Glu Ser Pro Phe Ser Arg Thr Gly Glu Gly Leu Asp Ile Arg Gly Thr 
            180                 185                 190         


Gln Gly Phe Pro Trp Val Ser Pro Ser Pro Pro Gln Gln Arg Leu Pro 
        195                 200                 205             


Leu Leu Glu Cys Thr Pro Gln Ser Gln Ser Glu Ser Lys Lys Asn Arg 
    210                 215                 220                 


Arg Gly Gly Arg Glu Asp Ile Leu Glu Lys Trp Ile Thr Thr Arg Arg 
225                 230                 235                 240 


Lys Ala Glu Glu Leu Glu Lys Asp Leu Arg Lys Ala Arg Lys Thr Ile 
                245                 250                 255     


Lys Lys Leu Glu Asp Glu Asn Pro Trp Leu Gly Asn Ile Ile Gly Ile 
            260                 265                 270         


Ile Arg Lys Gly Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Pro 
        275                 280                 285             


Arg Thr Asp Gln Met Glu Ile Asp Ser Gly Thr Gly Lys Arg Pro His 
    290                 295                 300                 


Lys Ser Gly Phe Thr Asp Lys Glu Arg Glu Asp His Arg Arg Arg Lys 
305                 310                 315                 320 


Ala Leu Glu Asn Lys Lys Lys Gln Leu Ser Ser Gly Gly Lys Asn Leu 
                325                 330                 335     


Ser Arg Glu Glu Glu Glu Glu Leu Gly Arg Leu Thr Val Glu Asp Glu 
            340                 345                 350         


Glu Arg Arg Arg Arg Val Ala Gly Pro Arg Thr Gly Asp Val Asn Leu 
        355                 360                 365             


Ser Gly Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Arg 
    370                 375                 380                 


Met Glu Gly Val Pro Glu Ser Pro Phe Thr Arg Thr Gly Glu Gly Leu 
385                 390                 395                 400 


Asp Ile Arg Gly Asn Gln Gly Phe Pro Trp Val Arg Pro Ser Pro Pro 
                405                 410                 415     


Gln Gln Arg Leu Pro Leu Leu Glu Cys Thr Pro Gln Gly Thr Asn Leu 
            420                 425                 430         


Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro 
        435                 440                 445             


Ala Phe Arg Ala Asn Ser Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn 
    450                 455                 460                 


Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly Gly Gln Asn Leu Ser 
465                 470                 475                 480 


Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala 
                485                 490                 495     


Phe Arg Ala Asn Thr Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys 
            500                 505                 510         


Asp Thr Trp Pro Asp Ala Asn Lys Val Gly 
        515                 520         


<210>  33
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Delta-9 polypeptide sequence

<400>  33

Met Ala Ser Arg Ser Glu Ser Lys Lys Asn Arg Gly Gly Arg Glu Glu 
1               5                   10                  15      


Ile Leu Glu Gln Trp Val Gly Ala Arg Lys Lys Leu Glu Glu Leu Glu 
            20                  25                  30          


Arg Asp Leu Arg Lys Ile Lys Lys Lys Ile Lys Lys Leu Glu Glu Glu 
        35                  40                  45              


Asn Pro Trp Leu Gly Asn Ile Lys Gly Ile Leu Gly Lys Lys Asp Arg 
    50                  55                  60                  


Glu Gly Glu Gly Ala Pro Pro Ala Lys Arg Ala Arg Ala Asp Gln Met 
65                  70                  75                  80  


Glu Val Asp Ser Gly Pro Arg Lys Arg Pro Phe Arg Gly Glu Phe Thr 
                85                  90                  95      


Asp Lys Glu Arg Arg Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys 
            100                 105                 110         


Arg Lys Gln Leu Ser Ser Gly Gly Lys Ser Leu Ser Lys Glu Glu Glu 
        115                 120                 125             


Glu Glu Leu Arg Lys Leu Thr Glu Glu Asp Glu Arg Arg Glu Arg Arg 
    130                 135                 140                 


Val Ala Gly Pro Arg Val Gly Gly Val Asn Pro Leu Glu Gly Gly Thr 
145                 150                 155                 160 


Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Ser Met Gln Gly Val Pro 
                165                 170                 175     


Glu Ser Pro Phe Ala Arg Thr Gly Glu Gly Leu Asp Val Arg Gly Asn 
            180                 185                 190         


Gln Gly Phe Pro Trp Asp Ile Leu Phe Pro Ala Asp Pro Pro Phe Ser 
        195                 200                 205             


Pro Gln Ser Cys Arg Pro Gln Ser Arg Ser Glu Ser Lys Lys Asn Arg 
    210                 215                 220                 


Gly Gly Arg Glu Glu Val Leu Glu Gln Trp Val Asn Gly Arg Lys Lys 
225                 230                 235                 240 


Leu Glu Glu Leu Glu Arg Glu Leu Arg Arg Ala Arg Lys Lys Ile Lys 
                245                 250                 255     


Lys Leu Glu Asp Asp Asn Pro Trp Leu Gly Asn Val Lys Gly Ile Leu 
            260                 265                 270         


Gly Lys Lys Asp Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Ala 
        275                 280                 285             


Arg Thr Asp Gln Met Glu Ile Asp Ser Gly Pro Arg Lys Arg Pro Leu 
    290                 295                 300                 


Arg Gly Gly Phe Thr Asp Arg Glu Arg Gln Asp His Arg Arg Arg Lys 
305                 310                 315                 320 


Ala Leu Lys Asn Lys Lys Lys Gln Leu Ser Ala Gly Gly Lys Ser Leu 
                325                 330                 335     


Ser Lys Glu Glu Glu Glu Glu Leu Lys Arg Leu Thr Arg Glu Asp Glu 
            340                 345                 350         


Glu Arg Lys Lys Glu Glu His Gly Pro Ser Arg Leu Gly Val Asn Pro 
        355                 360                 365             


Ser Glu Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Ser 
    370                 375                 380                 


Met Gln Gly Ile Pro Glu Ser Arg Phe Thr Arg Thr Gly Glu Gly Leu 
385                 390                 395                 400 


Asp Val Arg Gly Ser Arg Gly Phe Pro Gln Asp Ile Leu Phe Pro Ser 
                405                 410                 415     


Asp Pro Pro Phe Ser Pro Gln Ser Cys Arg Pro Gln 
            420                 425             


<210>  34
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Delta-10 polypeptide sequence

<400>  34

Met Ala Ser Gln Ser Glu Thr Arg Arg Gly Arg Arg Gly Thr Arg Glu 
1               5                   10                  15      


Glu Thr Leu Glu Lys Trp Ile Thr Ala Arg Lys Lys Ala Glu Glu Leu 
            20                  25                  30          


Glu Lys Asp Leu Arg Lys Thr Arg Lys Thr Ile Lys Lys Leu Glu Glu 
        35                  40                  45              


Glu Asn Pro Trp Leu Gly Asn Ile Val Gly Ile Ile Arg Lys Gly Lys 
    50                  55                  60                  


Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Pro Arg Thr Asp Gln Met 
65                  70                  75                  80  


Glu Val Asp Ser Gly Pro Gly Lys Arg Pro His Lys Ser Gly Phe Thr 
                85                  90                  95      


Asp Lys Glu Arg Glu Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys 
            100                 105                 110         


Lys Lys Gln Leu Ser Ala Gly Gly Lys Ile Leu Ser Lys Glu Glu Glu 
        115                 120                 125             


Glu Glu Leu Arg Arg Leu Thr Asp Glu Asp Glu Glu Arg Lys Arg Arg 
    130                 135                 140                 


Val Ala Gly Pro Arg Val Gly Asp Val Asn Pro Ser Arg Gly Gly Pro 
145                 150                 155                 160 


Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Gln Met Ala Gly Val Pro 
                165                 170                 175     


Glu Ser Pro Phe Ser Arg Thr Gly Glu Gly Leu Asp Ile Arg Gly Thr 
            180                 185                 190         


Gln Gly Phe Pro Trp Val Ser Pro Ser Pro Pro Gln Gln Arg Leu Pro 
        195                 200                 205             


Leu Leu Glu Cys Thr Pro Gln Ser Gln Ser Glu Ser Lys Lys Asn Arg 
    210                 215                 220                 


Arg Gly Gly Arg Glu Asp Ile Leu Glu Lys Trp Ile Thr Thr Arg Arg 
225                 230                 235                 240 


Lys Ala Glu Glu Leu Glu Lys Asp Leu Arg Lys Ala Arg Lys Thr Ile 
                245                 250                 255     


Lys Lys Leu Glu Asp Glu Asn Pro Trp Leu Gly Asn Ile Ile Gly Ile 
            260                 265                 270         


Ile Arg Lys Gly Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Pro 
        275                 280                 285             


Arg Thr Asp Gln Met Glu Ile Asp Ser Gly Thr Gly Lys Arg Pro His 
    290                 295                 300                 


Lys Ser Gly Phe Thr Asp Lys Glu Arg Glu Asp His Arg Arg Arg Lys 
305                 310                 315                 320 


Ala Leu Glu Asn Lys Lys Lys Gln Leu Ser Ser Gly Gly Lys Asn Leu 
                325                 330                 335     


Ser Arg Glu Glu Glu Glu Glu Leu Gly Arg Leu Thr Val Glu Asp Glu 
            340                 345                 350         


Glu Arg Arg Arg Arg Val Ala Gly Pro Arg Thr Gly Asp Val Asn Leu 
        355                 360                 365             


Ser Gly Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Arg 
    370                 375                 380                 


Met Glu Gly Val Pro Glu Ser Pro Phe Thr Arg Thr Gly Glu Gly Leu 
385                 390                 395                 400 


Asp Ile Arg Gly Asn Gln Gly Phe Pro Trp Val Arg Pro Ser Pro Pro 
                405                 410                 415     


Gln Gln Arg Leu Pro Leu Leu Glu Cys Thr Pro Gln 
            420                 425             


<210>  35
<211>  3434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Wild-type Delta-7/Delta-8 fusion nucleic acid sequence

<400>  35
aagcttgcac catggccggc accaacctga gcaccagcaa cccgctgggc ttttttccgg       60

atcatcagct ggatccggcg tttcgcgcga acagcgcgaa cccggattgg gattttaacc      120

cgaacaaaga tacctggccg gatgcgaaca aagtgggcgg ccagaacctg agcaccagca      180

acccgctggg cttttttccg gatcatcagc tggatccggc gtttcgcgcg aacaccgcga      240

acccggattg ggattttaac ccgaacaaag atacctggcc ggatgcgaac aaagtgggca      300

gccgcagcga aagcaaaaaa aaccgcggcg gccgcgaaga aattctggaa cagtgggtgg      360

gcgcgcgcaa aaaactggaa gaactggaac gcgatctgcg caaaattaaa aaaaaaatta      420

aaaaactgga agaagaaaac ccgtggctgg gcaacattaa aggcattctg ggcaaaaaag      480

atcgcgaagg cgaaggcgcg ccgccggcga aacgcgcgcg cgcggatcag atggaagtgg      540

atagcggccc gcgcaaacgc ccgtttcgcg gcgaatttac cgataaagaa cgccgcgatc      600

atcgccgccg caaagcgctg gaaaacaaac gcaaacagct gagcagcggc ggcaaaagcc      660

tgagcaaaga agaagaagaa gaactgcgca aactgaccga agaagatgaa cgccgcgaac      720

gccgcgtggc gggcccgcgc gtgggcggcg tgaacccgct ggaaggcggc acccgcggcg      780

cgccgggcgg cggctttgtg ccgagcatgc agggcgtgcc ggaaagcccg tttgcgcgca      840

ccggcgaagg cctggatgtg cgcggcaacc agggctttcc gtgggatatt ctgtttccgg      900

cggatccgcc gtttagcccg cagagctgcc gcccgcagag ccgcagcgaa agcaaaaaaa      960

accgcggcgg ccgcgaagaa gtgctggaac agtgggtgaa cggccgcaaa aaactggaag     1020

aactggaacg cgaactgcgc cgcgcgcgca aaaaaattaa aaaactggaa gatgataacc     1080

cgtggctggg caacgtgaaa ggcattctgg gcaaaaaaga taaagatggc gaaggcgcgc     1140

cgccggcgaa acgcgcgcgc accgatcaga tggaaattga tagcggcccg cgcaaacgcc     1200

cgctgcgcgg cggctttacc gatcgcgaac gccaggatca tcgccgccgc aaagcgctga     1260

aaaacaaaaa aaaacagctg agcgcgggcg gcaaaagcct gagcaaagaa gaagaagaag     1320

aactgaaacg cctgacccgc gaagatgaag aacgcaaaaa agaagaacat ggcccgagcc     1380

gcctgggcgt gaacccgagc gaaggcggcc cgcgcggcgc gccgggcggc ggctttgtgc     1440

cgagcatgca gggcattccg gaaagccgct ttacccgcac cggcgaaggc ctggatgtgc     1500

gcggcagccg cggctttccg caggatattc tgtttccgag cgatccgccg tttagcccgc     1560

agagctgccg cccgcagggc accaacctga gcaccagcaa cccgctgggc ttttttccgg     1620

atcatcagct ggatccggcg tttcgcgcga acagcgcgaa cccggattgg gattttaacc     1680

cgaacaaaga tacctggccg gatgcgaaca aagtgggcgg ccagaacctg agcaccagca     1740

acccgctggg cttttttccg gatcatcagc tggatccggc gtttcgcgcg aacaccgcga     1800

acccggattg ggattttaac ccgaacaaag atacctggcc ggatgcgaac aaagtgggca     1860

gccagagcga aacccgccgc ggccgccgcg gcacccgcga agaaaccctg gaaaaatgga     1920

ttaccgcgcg caaaaaagcg gaagaactgg aaaaagatct gcgcaaaacc cgcaaaacca     1980

ttaaaaaact ggaagaagaa aacccgtggc tgggcaacat tgtgggcatt attcgcaaag     2040

gcaaagatgg cgaaggcgcg ccgccggcga aacgcccgcg caccgatcag atggaagtgg     2100

atagcggccc gggcaaacgc ccgcataaaa gcggctttac cgataaagaa cgcgaagatc     2160

atcgccgccg caaagcgctg gaaaacaaaa aaaaacagct gagcgcgggc ggcaaaattc     2220

tgagcaaaga agaagaagaa gaactgcgcc gcctgaccga tgaagatgaa gaacgcaaac     2280

gccgcgtggc gggcccgcgc gtgggcgatg tgaacccgag ccgcggcggc ccgcgcggcg     2340

cgccgggcgg cggctttgtg ccgcagatgg cgggcgtgcc ggaaagcccg tttagccgca     2400

ccggcgaagg cctggatatt cgcggcaccc agggctttcc gtgggtgagc ccgagcccgc     2460

cgcagcagcg cctgccgctg ctggaatgca ccccgcagag ccagagcgaa agcaaaaaaa     2520

accgccgcgg cggccgcgaa gatattctgg aaaaatggat taccacccgc cgcaaagcgg     2580

aagaactgga aaaagatctg cgcaaagcgc gcaaaaccat taaaaaactg gaagatgaaa     2640

acccgtggct gggcaacatt attggcatta ttcgcaaagg caaagatggc gaaggcgcgc     2700

cgccggcgaa acgcccgcgc accgatcaga tggaaattga tagcggcacc ggcaaacgcc     2760

cgcataaaag cggctttacc gataaagaac gcgaagatca tcgccgccgc aaagcgctgg     2820

aaaacaaaaa aaaacagctg agcagcggcg gcaaaaacct gagccgcgaa gaagaagaag     2880

aactgggccg cctgaccgtg gaagatgaag aacgccgccg ccgcgtggcg ggcccgcgca     2940

ccggcgatgt gaacctgagc ggcggcggcc cgcgcggcgc gccgggcggc ggctttgtgc     3000

cgcgcatgga aggcgtgccg gaaagcccgt ttacccgcac cggcgaaggc ctggatattc     3060

gcggcaacca gggctttccg tgggtgcgcc cgagcccgcc gcagcagcgc ctgccgctgc     3120

tggaatgcac cccgcagggc accaacctga gcaccagcaa cccgctgggc ttttttccgg     3180

atcatcagct ggatccggcg tttcgcgcga acagcgcgaa cccggattgg gattttaacc     3240

cgaacaaaga tacctggccg gatgcgaaca aagtgggcgg ccagaacctg agcaccagca     3300

acccgctggg cttttttccg gatcatcagc tggatccggc gtttcgcgcg aacaccgcga     3360

acccggattg ggattttaac ccgaacaaag atacctggcc ggatgcgaac aaagtgggct     3420

gatgagaatt ccgt                                                       3434


<210>  36
<211>  3431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized Delta-7/Delta-8 fusion nucleic acid sequence

<400>  36
aagcttgcac catggcaggc accaatctgt caacctctaa ccctctgggc tttttccccg       60

accatcagct ggaccccgca ttccgagcaa actccgctaa ccctgactgg gatttcaacc      120

caaataagga cacctggccc gatgccaata aggtcggcgg ccagaacctg tccacatcta      180

atccactggg cttctttccc gaccaccagc tggatcctgc cttccgggcc aacacagcca      240

atcctgactg ggacttcaac cctaataagg atacctggcc cgatgccaac aaggtcggca      300

gcaggtccga gtctaagaag aataggggag gaagggagga gatcctggag cagtgggtgg      360

gagcacgcaa gaagctggag gagctggagc gggacctgag aaagatcaag aagaagatca      420

agaagctgga ggaggagaac ccctggctgg gcaatatcaa gggcatcctg ggcaagaagg      480

atcgggaggg agagggagca ccacctgcaa agagggccag agccgaccag atggaggtgg      540

attccggccc taggaagcgc ccattcagag gcgagtttac cgacaaggag cggagagatc      600

acaggcgccg gaaggccctg gagaacaagc ggaagcagct gagctccggc ggcaagagcc      660

tgtccaagga ggaggaggag gagctgagaa agctgacaga ggaggacgag agaagggaga      720

ggagggtggc aggacctagg gtgggaggcg tgaacccact ggagggagga accaggggag      780

cacctggagg aggattcgtg ccatccatgc agggagtgcc tgagtctcca tttgccagga      840

caggagaggg cctggacgtg cgcggaaatc agggcttccc ctgggacatc ctgtttcctg      900

ccgatccacc cttctcccct cagtcttgca ggccacagtc tcgcagcgag tccaagaaga      960

acagaggcgg aagggaggag gtgctggagc agtgggtgaa tggccggaag aagctggaag     1020

aactggagag ggagctgaga agggcccgca agaagatcaa gaagctggaa gacgataatc     1080

cttggctggg caatgtgaaa ggcatcctgg gcaagaagga caaggatgga gagggagcac     1140

ctccagcaaa gagggcaaga accgaccaga tggagatcga ttctggacca aggaagcgcc     1200

ctctgagagg aggcttcaca gaccgggaga gacaggatca ccgccggaga aaggccctga     1260

agaacaagaa gaagcagctg agcgccggcg gcaagtctct gagtaaagaa gaagaggagg     1320

agctgaagcg gctgaccaga gaggacgagg agcggaagaa ggaggagcac ggaccaagca     1380

gactgggagt gaatccttcc gagggaggac caagaggagc acccggagga ggcttcgtgc     1440

catctatgca gggcatcccc gagagcaggt ttaccagaac cggcgaaggc ctggacgtgc     1500

ggggctccag aggctttcct caggacatcc tgttcccatc tgatccccct tttagccccc     1560

agtcctgtag gcctcagggc accaacctgt ccacatctaa ccctctgggc ttctttcctg     1620

atcatcagct ggacccagcc ttccgcgcca acagcgccaa tcccgattgg gacttcaacc     1680

caaataagga tacctggcca gacgctaaca aggtcggagg acagaacctg agcacatcca     1740

atcctctggg cttctttcca gaccaccagc tggatccagc cttcagggct aatacagcca     1800

atcccgactg ggacttcaac ccaaataagg acacgtggcc agacgcaaac aaggtcggct     1860

ctcagagcga gacaaggagg ggccggagag gaaccaggga ggagacactg gagaagtgga     1920

tcaccgccag aaagaaggcc gaggagctgg agaaggacct gaggaagacc cgcaagacaa     1980

tcaagaagct ggaagaagag aacccatggc tgggcaatat cgtgggcatc atccgcaagg     2040

gcaaggacgg cgagggagca ccaccagcaa agaggcccag gactgatcag atggaggtgg     2100

atagcggccc tggcaagagg ccacacaagt ccggcttcac agacaaggag agggaggacc     2160

ataggcgccg gaaggccctg gaaaacaaga agaagcaatt atccgccggc ggcaagatcc     2220

tgtctaaaga agaggaagaa gagctgagaa ggctgaccga cgaggatgag gagaggaaaa     2280

gaagggtggc aggaccaaga gtgggcgacg tgaatccctc cagaggcgga ccaagaggag     2340

cacctggagg cggcttcgtg ccccagatgg ccggcgtgcc cgagtctcct tttagcagaa     2400

ccggagaggg cctggatatc aggggaaccc agggctttcc atgggtgtcc ccatctcctc     2460

cacagcagcg gctgccactg ctggagtgca cccctcagag ccagagcgaa tctaagaaga     2520

acagaagggg cggcagagag gacatcctgg aaaaatggat caccacacgc agaaaagctg     2580

aagaactgga aaaggacctg cggaaggcca gaaaaacaat caagaagctg gaggatgaaa     2640

atccatggct gggaaacatc atcggcatca tcagaaaggg caaggacggg gaaggcgcac     2700

cacctgcaaa gcggcctaga acagatcaga tggaaatcga ttctggaacc ggcaagcggc     2760

cacacaagag cggcttcacc gacaaggaga gagaggatca cagaaggcgc aaggccctgg     2820

agaacaagaa gaagcaatta agcagcggcg gcaagaatct gtccagagaa gaggaagagg     2880

agctgggcag actgaccgtg gaggacgagg agcggagaag gcgcgtggca ggacccagga     2940

caggcgatgt gaacctgagc ggaggaggac ctaggggagc accaggaggc ggcttcgtgc     3000

ctaggatgga gggagtgcca gagtccccct ttaccagaac cggcgagggc ctggacatca     3060

ggggaaatca gggattccca tgggtgcggc cttccccacc acagcagaga ctgccactgc     3120

tggagtgtac cccccagggc acaaacctga gcacctccaa tcccctgggc ttctttcctg     3180

accatcagct ggaccctgcc ttcagggcca acagcgccaa cccagattgg gacttcaacc     3240

ctaataagga cacctggcca gatgcaaaca aggtcggcgg ccaaaacctg tctacaagca     3300

accccctggg cttctttcca gatcaccagc tggatcccgc ctttcgcgcc aataccgcca     3360

accctgattg ggatttcaac cctaacaaag acacttggcc tgacgctaat aaggtcggct     3420

gatgagaatt c                                                          3431


<210>  37
<211>  1136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Delta-7/Delta-8 fusion polypeptide sequence

<400>  37

Met Ala Gly Thr Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro 
1               5                   10                  15      


Asp His Gln Leu Asp Pro Ala Phe Arg Ala Asn Ser Ala Asn Pro Asp 
            20                  25                  30          


Trp Asp Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val 
        35                  40                  45              


Gly Gly Gln Asn Leu Ser Thr Ser Asn Pro Leu Gly Phe Phe Pro Asp 
    50                  55                  60                  


His Gln Leu Asp Pro Ala Phe Arg Ala Asn Thr Ala Asn Pro Asp Trp 
65                  70                  75                  80  


Asp Phe Asn Pro Asn Lys Asp Thr Trp Pro Asp Ala Asn Lys Val Gly 
                85                  90                  95      


Ser Arg Ser Glu Ser Lys Lys Asn Arg Gly Gly Arg Glu Glu Ile Leu 
            100                 105                 110         


Glu Gln Trp Val Gly Ala Arg Lys Lys Leu Glu Glu Leu Glu Arg Asp 
        115                 120                 125             


Leu Arg Lys Ile Lys Lys Lys Ile Lys Lys Leu Glu Glu Glu Asn Pro 
    130                 135                 140                 


Trp Leu Gly Asn Ile Lys Gly Ile Leu Gly Lys Lys Asp Arg Glu Gly 
145                 150                 155                 160 


Glu Gly Ala Pro Pro Ala Lys Arg Ala Arg Ala Asp Gln Met Glu Val 
                165                 170                 175     


Asp Ser Gly Pro Arg Lys Arg Pro Phe Arg Gly Glu Phe Thr Asp Lys 
            180                 185                 190         


Glu Arg Arg Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys Arg Lys 
        195                 200                 205             


Gln Leu Ser Ser Gly Gly Lys Ser Leu Ser Lys Glu Glu Glu Glu Glu 
    210                 215                 220                 


Leu Arg Lys Leu Thr Glu Glu Asp Glu Arg Arg Glu Arg Arg Val Ala 
225                 230                 235                 240 


Gly Pro Arg Val Gly Gly Val Asn Pro Leu Glu Gly Gly Thr Arg Gly 
                245                 250                 255     


Ala Pro Gly Gly Gly Phe Val Pro Ser Met Gln Gly Val Pro Glu Ser 
            260                 265                 270         


Pro Phe Ala Arg Thr Gly Glu Gly Leu Asp Val Arg Gly Asn Gln Gly 
        275                 280                 285             


Phe Pro Trp Asp Ile Leu Phe Pro Ala Asp Pro Pro Phe Ser Pro Gln 
    290                 295                 300                 


Ser Cys Arg Pro Gln Ser Arg Ser Glu Ser Lys Lys Asn Arg Gly Gly 
305                 310                 315                 320 


Arg Glu Glu Val Leu Glu Gln Trp Val Asn Gly Arg Lys Lys Leu Glu 
                325                 330                 335     


Glu Leu Glu Arg Glu Leu Arg Arg Ala Arg Lys Lys Ile Lys Lys Leu 
            340                 345                 350         


Glu Asp Asp Asn Pro Trp Leu Gly Asn Val Lys Gly Ile Leu Gly Lys 
        355                 360                 365             


Lys Asp Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg Ala Arg Thr 
    370                 375                 380                 


Asp Gln Met Glu Ile Asp Ser Gly Pro Arg Lys Arg Pro Leu Arg Gly 
385                 390                 395                 400 


Gly Phe Thr Asp Arg Glu Arg Gln Asp His Arg Arg Arg Lys Ala Leu 
                405                 410                 415     


Lys Asn Lys Lys Lys Gln Leu Ser Ala Gly Gly Lys Ser Leu Ser Lys 
            420                 425                 430         


Glu Glu Glu Glu Glu Leu Lys Arg Leu Thr Arg Glu Asp Glu Glu Arg 
        435                 440                 445             


Lys Lys Glu Glu His Gly Pro Ser Arg Leu Gly Val Asn Pro Ser Glu 
    450                 455                 460                 


Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro Ser Met Gln 
465                 470                 475                 480 


Gly Ile Pro Glu Ser Arg Phe Thr Arg Thr Gly Glu Gly Leu Asp Val 
                485                 490                 495     


Arg Gly Ser Arg Gly Phe Pro Gln Asp Ile Leu Phe Pro Ser Asp Pro 
            500                 505                 510         


Pro Phe Ser Pro Gln Ser Cys Arg Pro Gln Gly Thr Asn Leu Ser Thr 
        515                 520                 525             


Ser Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe 
    530                 535                 540                 


Arg Ala Asn Ser Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys Asp 
545                 550                 555                 560 


Thr Trp Pro Asp Ala Asn Lys Val Gly Gly Gln Asn Leu Ser Thr Ser 
                565                 570                 575     


Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Arg 
            580                 585                 590         


Ala Asn Thr Ala Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys Asp Thr 
        595                 600                 605             


Trp Pro Asp Ala Asn Lys Val Gly Ser Gln Ser Glu Thr Arg Arg Gly 
    610                 615                 620                 


Arg Arg Gly Thr Arg Glu Glu Thr Leu Glu Lys Trp Ile Thr Ala Arg 
625                 630                 635                 640 


Lys Lys Ala Glu Glu Leu Glu Lys Asp Leu Arg Lys Thr Arg Lys Thr 
                645                 650                 655     


Ile Lys Lys Leu Glu Glu Glu Asn Pro Trp Leu Gly Asn Ile Val Gly 
            660                 665                 670         


Ile Ile Arg Lys Gly Lys Asp Gly Glu Gly Ala Pro Pro Ala Lys Arg 
        675                 680                 685             


Pro Arg Thr Asp Gln Met Glu Val Asp Ser Gly Pro Gly Lys Arg Pro 
    690                 695                 700                 


His Lys Ser Gly Phe Thr Asp Lys Glu Arg Glu Asp His Arg Arg Arg 
705                 710                 715                 720 


Lys Ala Leu Glu Asn Lys Lys Lys Gln Leu Ser Ala Gly Gly Lys Ile 
                725                 730                 735     


Leu Ser Lys Glu Glu Glu Glu Glu Leu Arg Arg Leu Thr Asp Glu Asp 
            740                 745                 750         


Glu Glu Arg Lys Arg Arg Val Ala Gly Pro Arg Val Gly Asp Val Asn 
        755                 760                 765             


Pro Ser Arg Gly Gly Pro Arg Gly Ala Pro Gly Gly Gly Phe Val Pro 
    770                 775                 780                 


Gln Met Ala Gly Val Pro Glu Ser Pro Phe Ser Arg Thr Gly Glu Gly 
785                 790                 795                 800 


Leu Asp Ile Arg Gly Thr Gln Gly Phe Pro Trp Val Ser Pro Ser Pro 
                805                 810                 815     


Pro Gln Gln Arg Leu Pro Leu Leu Glu Cys Thr Pro Gln Ser Gln Ser 
            820                 825                 830         


Glu Ser Lys Lys Asn Arg Arg Gly Gly Arg Glu Asp Ile Leu Glu Lys 
        835                 840                 845             


Trp Ile Thr Thr Arg Arg Lys Ala Glu Glu Leu Glu Lys Asp Leu Arg 
    850                 855                 860                 


Lys Ala Arg Lys Thr Ile Lys Lys Leu Glu Asp Glu Asn Pro Trp Leu 
865                 870                 875                 880 


Gly Asn Ile Ile Gly Ile Ile Arg Lys Gly Lys Asp Gly Glu Gly Ala 
                885                 890                 895     


Pro Pro Ala Lys Arg Pro Arg Thr Asp Gln Met Glu Ile Asp Ser Gly 
            900                 905                 910         


Thr Gly Lys Arg Pro His Lys Ser Gly Phe Thr Asp Lys Glu Arg Glu 
        915                 920                 925             


Asp His Arg Arg Arg Lys Ala Leu Glu Asn Lys Lys Lys Gln Leu Ser 
    930                 935                 940                 


Ser Gly Gly Lys Asn Leu Ser Arg Glu Glu Glu Glu Glu Leu Gly Arg 
945                 950                 955                 960 


Leu Thr Val Glu Asp Glu Glu Arg Arg Arg Arg Val Ala Gly Pro Arg 
                965                 970                 975     


Thr Gly Asp Val Asn Leu Ser Gly Gly Gly Pro Arg Gly Ala Pro Gly 
            980                 985                 990         


Gly Gly Phe Val Pro Arg Met Glu  Gly Val Pro Glu Ser  Pro Phe Thr 
        995                 1000                 1005             


Arg Thr  Gly Glu Gly Leu Asp  Ile Arg Gly Asn Gln  Gly Phe Pro 
    1010                 1015                 1020             


Trp Val  Arg Pro Ser Pro Pro  Gln Gln Arg Leu Pro  Leu Leu Glu 
    1025                 1030                 1035             


Cys Thr  Pro Gln Gly Thr Asn  Leu Ser Thr Ser Asn  Pro Leu Gly 
    1040                 1045                 1050             


Phe Phe  Pro Asp His Gln Leu  Asp Pro Ala Phe Arg  Ala Asn Ser 
    1055                 1060                 1065             


Ala Asn  Pro Asp Trp Asp Phe  Asn Pro Asn Lys Asp  Thr Trp Pro 
    1070                 1075                 1080             


Asp Ala  Asn Lys Val Gly Gly  Gln Asn Leu Ser Thr  Ser Asn Pro 
    1085                 1090                 1095             


Leu Gly  Phe Phe Pro Asp His  Gln Leu Asp Pro Ala  Phe Arg Ala 
    1100                 1105                 1110             


Asn Thr  Ala Asn Pro Asp Trp  Asp Phe Asn Pro Asn  Lys Asp Thr 
    1115                 1120                 1125             


Trp Pro  Asp Ala Asn Lys Val  Gly 
    1130                 1135     


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ovalbumin 257-264 CTL

<400>  38

Ser Ile Ile Asn Phe Glu Lys Leu 
1               5               


<210>  39
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ovalbumin 323-339 Th

<400>  39

Ile Ser Gln Ala Val His Ala Ala His Ala Glu Ile Asn Glu Ala Gly 
1               5                   10                  15      


Arg 
    


