
                                SEQUENCE LISTING

<110> Blouse, Grant E.
      Pekrun, Katja
      Kay, Mark A.

<120> GENE THERAPY FOR HEMOPHILIA B WITH A
  CHIMERIC AAV CAPSID VECTOR ENCODING MODIFIED FACTOR IX
  POLYPEPTIDES

<130> 33328-4956PC

<140> Not Yet Assigned
<141> Herewith

<150> 63/045,010        
<151> 2020-06-26 

<150> 62/967,568     
<151> 2020-01-29


<160> 575

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1383
<212> DNA
<213> Homo sapiens

<220> 
<223> Factor IX mRNA

<220> 
<221> sig_peptide    
<222> (1)...(84)

<220> 
<221> misc_feature   
<222> (85)...(138)
<223> propeptide

<220> 
<221> mat_peptide    
<222> (139)...(1383)
<223> zymogen

<400> 1
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta 60
ggatatctac tcagtgctga atgtacagtt tttcttgatc atgaaaacgc caacaaaatt 120
ctgaatcggc caaagaggta taattcaggt aaattggaag agtttgttca agggaacctt 180
gagagagaat gtatggaaga aaagtgtagt tttgaagaag cacgagaagt ttttgaaaac 240
actgaaagaa caactgaatt ttggaagcag tatgttgatg gagatcagtg tgagtccaat 300
ccatgtttaa atggcggcag ttgcaaggat gacattaatt cctatgaatg ttggtgtccc 360
tttggatttg aaggaaagaa ctgtgaatta gatgtaacat gtaacattaa gaatggcaga 420
tgcgagcagt tttgtaaaaa tagtgctgat aacaaggtgg tttgctcctg tactgaggga 480
tatcgacttg cagaaaacca gaagtcctgt gaaccagcag tgccatttcc atgtggaaga 540
gtttctgttt cacaaacttc taagctcacc cgtgctgaga ctgtttttcc tgatgtggac 600
tatgtaaatt ctactgaagc tgaaaccatt ttggataaca tcactcaaag cacccaatca 660
tttaatgact tcactcgggt tgttggtgga gaagatgcca aaccaggtca attcccttgg 720
caggttgttt tgaatggtaa agttgatgca ttctgtggag gctctatcgt taatgaaaaa 780
tggattgtaa ctgctgccca ctgtgttgaa actggtgtta aaattacagt tgtcgcaggt 840
gaacataata ttgaggagac agaacataca gagcaaaagc gaaatgtgat tcgaattatt 900
cctcaccaca actacaatgc agctattaat aagtacaacc atgacattgc ccttctggaa 960
ctggacgaac ccttagtgct aaacagctac gttacaccta tttgcattgc tgacaaggaa 1020
tacacgaaca tcttcctcaa atttggatct ggctatgtaa gtggctgggg aagagtcttc 1080
cacaaaggga gatcagcttt agttcttcag taccttagag ttccacttgt tgaccgagcc 1140
acatgtcttc gatctacaaa gttcaccatc tataacaaca tgttctgtgc tggcttccat 1200
gaaggaggta gagattcatg tcaaggagat agtgggggac cccatgttac tgaagtggaa 1260
gggaccagtt tcttaactgg aattattagc tggggtgaag agtgtgcaat gaaaggcaaa 1320
tatggaatat ataccaaggt atcccggtat gtcaactgga ttaaggaaaa aacaaagctc 1380
act                                                               1383

<210> 2
<211> 461
<212> PRT
<213> Homo sapiens

<220> 
<223> Precursor Factor IX

<220> 
<221> SIGNAL         
<222> (1)...(28)

<220> 
<221> PROPEP         
<222> (29)...(46)

<400> 2
Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr
 1               5                  10                  15      
Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu
            20                  25                  30          
Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn
        35                  40                  45              
Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys
    50                  55                  60                  
Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn
65                  70                  75                  80  
Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln
                85                  90                  95      
Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile
            100                 105                 110         
Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys
        115                 120                 125             
Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe
    130                 135                 140                 
Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly
145                 150                 155                 160 
Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe
                165                 170                 175     
Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala
            180                 185                 190         
Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu
        195                 200                 205             
Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe
    210                 215                 220                 
Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp
225                 230                 235                 240 
Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile
                245                 250                 255     
Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly
            260                 265                 270         
Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu
        275                 280                 285             
His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn
    290                 295                 300                 
Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu
305                 310                 315                 320 
Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile
                325                 330                 335     
Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr
            340                 345                 350         
Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val
        355                 360                 365             
Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg
    370                 375                 380                 
Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His
385                 390                 395                 400 
Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val
                405                 410                 415     
Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly
            420                 425                 430         
Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser
        435                 440                 445             
Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
    450                 455                 460     


<210> 3
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Mature Factor IX

<400> 3
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 4
<211> 461
<212> PRT
<213> Pan troglodytes

<220> 
<223> Chimpanzee Factor IX

<400> 4
Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr
 1               5                  10                  15      
Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu
            20                  25                  30          
Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn
        35                  40                  45              
Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys
    50                  55                  60                  
Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn
65                  70                  75                  80  
Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln
                85                  90                  95      
Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile
            100                 105                 110         
Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys
        115                 120                 125             
Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe
    130                 135                 140                 
Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly
145                 150                 155                 160 
Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe
                165                 170                 175     
Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala
            180                 185                 190         
Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu
        195                 200                 205             
Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe
    210                 215                 220                 
Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp
225                 230                 235                 240 
Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile
                245                 250                 255     
Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Asp Thr Gly
            260                 265                 270         
Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu
        275                 280                 285             
His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn
    290                 295                 300                 
Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu
305                 310                 315                 320 
Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile
                325                 330                 335     
Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr
            340                 345                 350         
Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val
        355                 360                 365             
Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg
    370                 375                 380                 
Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His
385                 390                 395                 400 
Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val
                405                 410                 415     
Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly
            420                 425                 430         
Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser
        435                 440                 445             
Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
    450                 455                 460     


<210> 5
<211> 461
<212> PRT
<213> Macaca mulatta

<220> 
<223> Rhesus macaque Factor IX

<400> 5
Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr
 1               5                  10                  15      
Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu
            20                  25                  30          
Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn
        35                  40                  45              
Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys
    50                  55                  60                  
Met Glu Glu Lys Cys Asn Phe Glu Glu Ala Arg Glu Val Phe Glu Asn
65                  70                  75                  80  
Thr Glu Lys Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln
                85                  90                  95      
Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile
            100                 105                 110         
Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys
        115                 120                 125             
Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Lys Gln Phe
    130                 135                 140                 
Cys Lys Asn Thr Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly
145                 150                 155                 160 
Tyr Arg Leu Ala Glu Asn Gln Arg Ser Cys Glu Pro Ala Val Pro Phe
                165                 170                 175     
Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Thr Leu Thr Arg Ala
            180                 185                 190         
Glu Thr Val Phe Pro Asp Val Glu Tyr Val Asn Ser Thr Glu Ala Glu
        195                 200                 205             
Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe
    210                 215                 220                 
Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp
225                 230                 235                 240 
Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile
                245                 250                 255     
Val Asn Glu Lys Trp Val Val Thr Ala Ala His Cys Val Glu Thr Asp
            260                 265                 270         
Ala Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu
        275                 280                 285             
His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn
    290                 295                 300                 
Tyr Asn Ala Thr Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu
305                 310                 315                 320 
Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile
                325                 330                 335     
Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr
            340                 345                 350         
Val Ser Gly Trp Gly Arg Val Phe Asn Lys Gly Arg Ser Ala Ser Val
        355                 360                 365             
Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg
    370                 375                 380                 
Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His
385                 390                 395                 400 
Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val
                405                 410                 415     
Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly
            420                 425                 430         
Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser
        435                 440                 445             
Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
    450                 455                 460     


<210> 6
<211> 471
<212> PRT
<213> Mus musculus

<220> 
<223> Mouse Factor IX

<400> 6
Met Lys His Leu Asn Thr Val Met Ala Glu Ser Pro Ala Leu Ile Thr
 1               5                  10                  15      
Ile Phe Leu Leu Gly Tyr Leu Leu Ser Thr Glu Cys Ala Val Phe Leu
            20                  25                  30          
Asp Arg Glu Asn Ala Thr Lys Ile Leu Thr Arg Pro Lys Arg Tyr Asn
        35                  40                  45              
Ser Gly Lys Leu Glu Glu Phe Val Arg Gly Asn Leu Glu Arg Glu Cys
    50                  55                  60                  
Ile Glu Glu Arg Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn
65                  70                  75                  80  
Thr Glu Lys Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln
                85                  90                  95      
Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ile Cys Lys Asp Asp Ile
            100                 105                 110         
Ser Ser Tyr Glu Cys Trp Cys Gln Val Gly Phe Glu Gly Arg Asn Cys
        115                 120                 125             
Glu Leu Asp Ala Thr Cys Asn Ile Lys Asn Gly Arg Cys Lys Gln Phe
    130                 135                 140                 
Cys Lys Asn Ser Pro Asp Asn Lys Val Ile Cys Ser Cys Thr Glu Gly
145                 150                 155                 160 
Tyr Gln Leu Ala Glu Asp Gln Lys Ser Cys Glu Pro Thr Val Pro Phe
                165                 170                 175     
Pro Cys Gly Arg Ala Ser Ile Ser Tyr Ser Ser Lys Lys Ile Thr Arg
            180                 185                 190         
Ala Glu Thr Val Phe Ser Asn Met Asp Tyr Glu Asn Ser Thr Glu Ala
        195                 200                 205             
Val Phe Ile Gln Asp Asp Ile Thr Asp Gly Ala Ile Leu Asn Asn Val
    210                 215                 220                 
Thr Glu Ser Ser Glu Ser Leu Asn Asp Phe Thr Arg Val Val Gly Gly
225                 230                 235                 240 
Glu Asn Ala Lys Pro Gly Gln Ile Pro Trp Gln Val Ile Leu Asn Gly
                245                 250                 255     
Glu Ile Glu Ala Phe Cys Gly Gly Ala Ile Ile Asn Glu Lys Trp Ile
            260                 265                 270         
Val Thr Ala Ala His Cys Leu Lys Pro Gly Asp Lys Ile Glu Val Val
        275                 280                 285             
Ala Gly Glu Tyr Asn Ile Asp Lys Lys Glu Asp Thr Glu Gln Arg Arg
    290                 295                 300                 
Asn Val Ile Arg Thr Ile Pro His His Gln Tyr Asn Ala Thr Ile Asn
305                 310                 315                 320 
Lys Tyr Ser His Asp Ile Ala Leu Leu Glu Leu Asp Lys Pro Leu Ile
                325                 330                 335     
Leu Asn Ser Tyr Val Thr Pro Ile Cys Val Ala Asn Arg Glu Tyr Thr
            340                 345                 350         
Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr Val Ser Gly Trp Gly Lys
        355                 360                 365             
Val Phe Asn Lys Gly Arg Gln Ala Ser Ile Leu Gln Tyr Leu Arg Val
    370                 375                 380                 
Pro Leu Val Asp Arg Ala Thr Cys Leu Arg Ser Thr Thr Phe Thr Ile
385                 390                 395                 400 
Tyr Asn Asn Met Phe Cys Ala Gly Tyr Arg Glu Gly Gly Lys Asp Ser
                405                 410                 415     
Cys Glu Gly Asp Ser Gly Gly Pro His Val Thr Glu Val Glu Gly Thr
            420                 425                 430         
Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly Glu Glu Cys Ala Met Lys
        435                 440                 445             
Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser Arg Tyr Val Asn Trp Ile
    450                 455                 460                 
Lys Glu Lys Thr Lys Leu Thr
465                 470     


<210> 7
<211> 282
<212> PRT
<213> Rattus norvegicus

<220> 
<223> Rat Factor IX

<400> 7
Arg Val Ser Val Ala Tyr Asn Ser Lys Lys Ile Thr Arg Ala Glu Thr
 1               5                  10                  15      
Val Phe Ser Asn Thr Asp Tyr Gly Asn Ser Thr Glu Leu Ile Leu Asp
            20                  25                  30          
Asp Ile Thr Asn Ser Thr Ile Leu Asp Asn Leu Thr Glu Asn Ser Glu
        35                  40                  45              
Pro Ile Asn Asp Phe Thr Arg Val Val Gly Gly Glu Asn Ala Lys Pro
    50                  55                  60                  
Gly Gln Ile Pro Trp Gln Val Ile Leu Asn Gly Glu Ile Glu Ala Phe
65                  70                  75                  80  
Cys Gly Gly Ala Ile Ile Asn Glu Lys Trp Ile Val Thr Ala Ala His
                85                  90                  95      
Cys Leu Lys Pro Gly Asp Lys Ile Glu Val Val Ala Gly Glu His Asn
            100                 105                 110         
Ile Asp Glu Lys Glu Asp Thr Glu Gln Arg Arg Asn Val Ile Arg Thr
        115                 120                 125             
Ile Pro His His Gln Tyr Asn Ala Thr Ile Asn Lys Tyr Ser His Asp
    130                 135                 140                 
Ile Ala Leu Leu Glu Leu Asp Lys Pro Leu Ile Leu Asn Ser Tyr Val
145                 150                 155                 160 
Thr Pro Ile Cys Val Ala Asn Lys Glu Tyr Thr Asn Ile Phe Leu Lys
                165                 170                 175     
Phe Gly Ser Gly Tyr Val Ser Gly Trp Gly Lys Val Phe Asn Lys Gly
            180                 185                 190         
Arg Gln Ala Ser Ile Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg
        195                 200                 205             
Ala Thr Cys Leu Arg Ser Thr Lys Phe Ser Ile Tyr Asn Asn Met Phe
    210                 215                 220                 
Cys Ala Gly Tyr Arg Glu Gly Gly Lys Asp Ser Cys Glu Gly Asp Ser
225                 230                 235                 240 
Gly Gly Pro His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly
                245                 250                 255     
Ile Ile Ser Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile
            260                 265                 270         
Tyr Thr Lys Val Ser Arg Tyr Val Asn Trp
        275                 280         


<210> 8
<211> 285
<212> PRT
<213> Cavia porcellus

<220> 
<223> Guinea pig Factor IX

<400> 8
Arg Val Ser Ile Pro Ser Val Ser Lys Glu His Asn Arg Ala Asn Ala
 1               5                  10                  15      
Ile Phe Ser Arg Met Gly Tyr Val Asn Phe Thr Asp Asp Glu Thr Ile
            20                  25                  30          
Trp Asp Asp Asn Asp Asp Asp Glu Thr Ile Trp Asp Asn Ser Thr Glu
        35                  40                  45              
Ser Thr Lys Pro Ser Asp Glu Phe Phe Arg Val Val Gly Gly Glu Asp
    50                  55                  60                  
Ala Lys Pro Gly Gln Phe Pro Trp Gln Val Leu Leu Asn Gly Glu Thr
65                  70                  75                  80  
Glu Ala Phe Cys Gly Gly Ser Ile Val Asn Glu Lys Trp Ile Val Thr
                85                  90                  95      
Ala Ala His Cys Ile Leu Pro Gly Ile Lys Ile Glu Val Val Ala Gly
            100                 105                 110         
Lys His Asn Ile Glu Lys Lys Glu Asp Thr Glu Gln Arg Arg Asn Val
        115                 120                 125             
Thr Gln Ile Ile Leu His His Ser Tyr Asn Ala Ser Phe Asn Lys Tyr
    130                 135                 140                 
Ser His Asp Ile Ala Leu Leu Glu Leu Asp Lys Pro Leu Ser Leu Asn
145                 150                 155                 160 
Ser Tyr Val Thr Pro Ile Cys Ile Ala Asn Arg Glu Tyr Thr Asn Ile
                165                 170                 175     
Phe Leu Lys Phe Gly Ala Gly Tyr Val Ser Gly Trp Gly Lys Leu Phe
            180                 185                 190         
Ser Gln Gly Arg Thr Ala Ser Ile Leu Gln Tyr Leu Arg Val Pro Leu
        195                 200                 205             
Val Asp Arg Ala Thr Cys Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn
    210                 215                 220                 
Asn Met Phe Cys Ala Gly Phe His Glu Gly Gly Arg Asp Ser Cys Gln
225                 230                 235                 240 
Gly Asp Ser Gly Gly Pro His Val Thr Glu Val Glu Gly Thr Asn Phe
                245                 250                 255     
Leu Thr Gly Ile Ile Ser Trp Gly Glu Glu Cys Ala Met Lys Gly Lys
            260                 265                 270         
Tyr Gly Ile Tyr Thr Lys Val Ser Arg Tyr Val Asn Trp
        275                 280                 285 


<210> 9
<211> 409
<212> PRT
<213> Sus scrofa

<220> 
<223> Pig Factor IX

<400> 9
Tyr Asn Ser Gly Lys Leu Glu Glu Ser Phe Val Arg Gly Asn Leu Glu
 1               5                  10                  15      
Arg Glu Cys Ile Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val
            20                  25                  30          
Phe Glu Asn Thr Glu Lys Thr Asn Glu Phe Trp Lys Gln Tyr Val Asp
        35                  40                  45              
Gly Asp Gln Cys Glu Pro Asn Pro Cys Leu Asn Gly Gly Leu Cys Lys
    50                  55                  60                  
Asp Asp Ile Asn Ser Tyr Glu Cys Trp Cys Gln Val Gly Phe Glu Gly
65                  70                  75                  80  
Lys Asn Cys Glu Leu Asp Ala Thr Cys Asn Ile Lys Asn Gly Arg Cys
                85                  90                  95      
Lys Gln Phe Cys Lys Thr Gly Ala Asp Ser Lys Val Leu Cys Ser Cys
            100                 105                 110         
Thr Thr Gly Tyr Arg Leu Ala Pro Asp Gln Lys Ser Cys Lys Pro Ala
        115                 120                 125             
Val Pro Phe Pro Cys Gly Arg Val Ser Val Ser His Ser Pro Thr Thr
    130                 135                 140                 
Leu Thr Arg Ala Glu Ile Ile Phe Ser Asn Met Asp Tyr Glu Asn Ser
145                 150                 155                 160 
Thr Glu Val Glu Pro Ile Leu Asp Ser Leu Thr Glu Ser Asn Gln Ser
                165                 170                 175     
Ser Asp Asp Phe Ile Arg Ile Val Gly Gly Glu Asn Ala Lys Pro Gly
            180                 185                 190         
Gln Phe Pro Trp Gln Val Leu Leu Asn Gly Lys Ile Asp Ala Phe Cys
        195                 200                 205             
Gly Gly Ser Ile Ile Asn Glu Lys Trp Val Val Thr Ala Ala His Cys
    210                 215                 220                 
Ile Glu Pro Gly Val Lys Ile Thr Val Val Ala Gly Glu Tyr Asn Thr
225                 230                 235                 240 
Glu Glu Thr Glu Pro Thr Glu Gln Arg Arg Asn Val Ile Arg Ala Ile
                245                 250                 255     
Pro His His Ser Tyr Asn Ala Thr Val Asn Lys Tyr Ser His Asp Ile
            260                 265                 270         
Ala Leu Leu Glu Leu Asp Glu Pro Leu Thr Leu Asn Ser Tyr Val Thr
        275                 280                 285             
Pro Ile Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe
    290                 295                 300                 
Gly Ser Gly Tyr Val Ser Gly Trp Gly Arg Val Phe Asn Arg Gly Arg
305                 310                 315                 320 
Ser Ala Thr Ile Leu Gln Tyr Leu Lys Val Pro Leu Val Asp Arg Ala
                325                 330                 335     
Thr Cys Leu Arg Ser Thr Lys Val Thr Ile Tyr Ser Asn Met Phe Cys
            340                 345                 350         
Ala Gly Phe His Glu Gly Gly Lys Asp Ser Cys Leu Gly Asp Ser Gly
        355                 360                 365             
Gly Pro His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile
    370                 375                 380                 
Ile Ser Trp Gly Glu Glu Cys Ala Val Lys Gly Lys Tyr Gly Ile Tyr
385                 390                 395                 400 
Thr Lys Val Ser Arg Tyr Val Asn Trp
                405                 


<210> 10
<211> 452
<212> PRT
<213> Canis familiaris

<220> 
<223> Dog Factor IX

<400> 10
Met Ala Glu Ala Ser Gly Leu Val Thr Val Cys Leu Leu Gly Tyr Leu
 1               5                  10                  15      
Leu Ser Ala Glu Cys Ala Val Phe Leu Asp Arg Glu Asn Ala Thr Lys
            20                  25                  30          
Ile Leu Ser Arg Pro Lys Arg Tyr Asn Ser Gly Lys Leu Glu Glu Phe
        35                  40                  45              
Val Arg Gly Asn Leu Glu Arg Glu Cys Ile Glu Glu Lys Cys Ser Phe
    50                  55                  60                  
Glu Glu Ala Arg Glu Val Phe Glu Asn Thr Glu Lys Thr Thr Glu Phe
65                  70                  75                  80  
Trp Lys Gln Tyr Val Asp Gly Asp Gln Cys Glu Ser Asn Pro Cys Leu
                85                  90                  95      
Asn Asp Gly Val Cys Lys Asp Asp Ile Asn Ser Tyr Glu Cys Trp Cys
            100                 105                 110         
Arg Ala Gly Phe Glu Gly Lys Asn Cys Glu Leu Asp Val Thr Cys Asn
        115                 120                 125             
Ile Lys Asn Gly Arg Cys Lys Gln Phe Cys Lys Leu Gly Pro Asp Asn
    130                 135                 140                 
Lys Val Val Cys Ser Cys Thr Thr Gly Tyr Gln Leu Ala Glu Asp Gln
145                 150                 155                 160 
Arg Ser Cys Glu Pro Ala Val Pro Phe Pro Cys Gly Arg Val Ser Val
                165                 170                 175     
Pro His Ile Ser Met Thr Arg Thr Arg Ala Glu Thr Leu Phe Ser Asn
            180                 185                 190         
Met Asp Tyr Glu Asn Ser Thr Glu Val Glu Lys Ile Leu Asp Asn Val
        195                 200                 205             
Thr Gln Pro Leu Asn Asp Phe Thr Arg Val Val Gly Gly Lys Asp Ala
    210                 215                 220                 
Lys Pro Gly Gln Phe Pro Trp Gln Val Leu Leu Asn Gly Lys Val Asp
225                 230                 235                 240 
Ala Phe Cys Gly Gly Ser Ile Ile Asn Glu Lys Trp Val Val Thr Ala
                245                 250                 255     
Ala His Cys Ile Glu Pro Asp Val Lys Ile Thr Ile Val Ala Gly Glu
            260                 265                 270         
His Asn Thr Glu Lys Arg Glu His Thr Glu Gln Lys Arg Asn Val Ile
        275                 280                 285             
Arg Thr Ile Leu His His Ser Tyr Asn Ala Thr Ile Asn Lys Tyr Asn
    290                 295                 300                 
His Asp Ile Ala Leu Leu Glu Leu Asp Glu Pro Leu Thr Leu Asn Ser
305                 310                 315                 320 
Tyr Val Thr Pro Ile Cys Ile Ala Asp Arg Glu Tyr Ser Asn Ile Phe
                325                 330                 335     
Leu Lys Phe Gly Ser Gly Tyr Val Ser Gly Trp Gly Arg Val Phe Asn
            340                 345                 350         
Lys Gly Arg Ser Ala Ser Ile Leu Gln Tyr Leu Lys Val Pro Leu Val
        355                 360                 365             
Asp Arg Ala Thr Cys Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn
    370                 375                 380                 
Met Phe Cys Ala Gly Phe His Glu Gly Gly Lys Asp Ser Cys Gln Gly
385                 390                 395                 400 
Asp Ser Gly Gly Pro His Val Thr Glu Val Glu Gly Ile Ser Phe Leu
                405                 410                 415     
Thr Gly Ile Ile Ser Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr
            420                 425                 430         
Gly Ile Tyr Thr Lys Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys
        435                 440                 445             
Thr Lys Leu Thr
    450         


<210> 11
<211> 466
<212> PRT
<213> Felis catus

<220> 
<223> Cat Factor IX

<400> 11
Met Arg Cys Leu Asn Met Ile Met Ala Glu Pro Pro Gly Leu Ile Thr
 1               5                  10                  15      
Ile Cys Leu Leu Gly Tyr Leu Leu Gly Ala Asp Cys Thr Val Phe Leu
            20                  25                  30          
Asp His Glu Asp Ala Thr Lys Val Leu Ser Arg Pro Lys Arg Tyr Asn
        35                  40                  45              
Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys
    50                  55                  60                  
Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn
65                  70                  75                  80  
Thr Glu Lys Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln
                85                  90                  95      
Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ile Cys Lys Asp Asp Ile
            100                 105                 110         
Asn Ser Tyr Glu Cys Trp Cys Gln Thr Gly Phe Glu Gly Lys Asn Cys
        115                 120                 125             
Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Lys Gln Phe
    130                 135                 140                 
Cys Lys Leu Asp Ala Asp Asn Lys Val Val Cys Ser Cys Thr Thr Gly
145                 150                 155                 160 
Tyr Gln Leu Ala Glu Asp Gln Lys Ser Cys Glu Pro Ala Val Pro Phe
                165                 170                 175     
Pro Cys Gly Arg Val Ser Val Pro His Ile Ser Thr Thr His Thr Arg
            180                 185                 190         
Ala Glu Thr Leu Phe Leu Asn Met Asp Tyr Glu Asn Ser Thr Thr Asp
        195                 200                 205             
Tyr Glu Asn Ser Ala Glu Ala Glu Lys Asn Val Asp Asn Val Thr Gln
    210                 215                 220                 
Pro Leu Asn Asp Leu Thr Arg Ile Val Gly Gly Lys Thr Ala Lys Pro
225                 230                 235                 240 
Gly Gln Phe Pro Trp Gln Val Leu Leu Lys Gly Lys Ile Asp Ala Phe
                245                 250                 255     
Cys Gly Gly Ser Ile Ile Asn Glu Lys Trp Val Val Thr Ala Ala His
            260                 265                 270         
Cys Ile Asn Pro Asp Val Glu Ile Thr Val Val Ala Gly Glu His Asn
        275                 280                 285             
Thr Glu Glu Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Thr
    290                 295                 300                 
Ile Leu His His Ser Tyr Asn Ala Ser Val Asn Lys Tyr Ser His Asp
305                 310                 315                 320 
Ile Ala Leu Leu Glu Leu Asp Glu Pro Leu Thr Leu Asn Ser Tyr Val
                325                 330                 335     
Thr Pro Ile Cys Val Ala Asp Arg Glu Tyr Thr Asn Thr Phe Leu Lys
            340                 345                 350         
Phe Gly Tyr Gly Tyr Val Ser Gly Trp Gly Lys Val Phe Asn Lys Gly
        355                 360                 365             
Arg Pro Ala Thr Ile Leu Gln Tyr Leu Lys Val Pro Leu Val Asp Arg
    370                 375                 380                 
Ala Thr Cys Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe
385                 390                 395                 400 
Cys Ala Gly Phe His Glu Gly Gly Lys Asp Ser Cys Gln Gly Asp Ser
                405                 410                 415     
Gly Gly Pro His Val Thr Glu Val Glu Gly Ile Asn Phe Leu Thr Gly
            420                 425                 430         
Ile Ile Ser Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile
        435                 440                 445             
Tyr Thr Lys Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys
    450                 455                 460                 
Leu Thr
465     


<210> 12
<211> 275
<212> PRT
<213> Oryctolagus cuniculus

<220> 
<223> Rabbit Factor IX

<400> 12
Gly Val Ser Val Ser His Ala Ser Lys Lys Ile Thr Arg Ala Thr Thr
 1               5                  10                  15      
Ile Phe Ser Asn Thr Glu Tyr Glu Asn Phe Thr Glu Ala Glu Thr Ile
            20                  25                  30          
Arg Gly Asn Val Thr Gln Arg Ser Gln Ser Ser Asp Asp Phe Thr Arg
        35                  40                  45              
Ile Val Gly Gly Glu Asn Ala Lys Pro Gly Gln Phe Pro Trp Gln Val
    50                  55                  60                  
Leu Leu Asn Gly Lys Val Glu Ala Phe Cys Gly Gly Ser Ile Ile Asn
65                  70                  75                  80  
Glu Lys Trp Val Val Thr Ala Ala His Cys Ile Lys Pro Asp Asp Asn
                85                  90                  95      
Ile Thr Val Val Ala Gly Glu Tyr Asn Ile Gln Glu Thr Glu Asn Thr
            100                 105                 110         
Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro Tyr His Lys Tyr Asn
        115                 120                 125             
Ala Thr Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu Leu Asp
    130                 135                 140                 
Lys Pro Leu Thr Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile Ala Asn
145                 150                 155                 160 
Arg Glu Tyr Thr Asn Ile Phe Leu Asn Phe Gly Ser Gly Tyr Val Ser
                165                 170                 175     
Gly Trp Gly Arg Val Phe Asn Arg Gly Arg Gln Ala Ser Ile Leu Gln
            180                 185                 190         
Tyr Leu Arg Val Pro Phe Val Asp Arg Ala Thr Cys Leu Arg Ser Thr
        195                 200                 205             
Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe Asp Val Gly
    210                 215                 220                 
Gly Lys Asp Ser Cys Glu Gly Asp Ser Gly Gly Pro His Val Thr Glu
225                 230                 235                 240 
Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly Glu Glu
                245                 250                 255     
Cys Ala Ile Lys Gly Lys Tyr Gly Val Tyr Thr Arg Val Ser Trp Tyr
            260                 265                 270         
Val Asn Trp
        275 


<210> 13
<211> 471
<212> PRT
<213> Gallus gallus

<220> 
<223> Chicken Factor IX

<400> 13
Met Ala Lys Ile Pro Leu Ile Leu Ser Phe Cys Leu Leu Glu Ala Phe
 1               5                  10                  15      
Leu Gly Ala Glu Ser Thr Val Phe Ile Glu Asn Lys Glu Ala Ser Thr
            20                  25                  30          
Val Leu Ser Arg Thr Arg Arg Gly Asn Ser Asn Arg Leu Glu Glu Leu
        35                  40                  45              
Ile Pro Gly Asn Leu Glu Arg Glu Cys Ile Glu Glu Lys Cys Ser Phe
    50                  55                  60                  
Glu Glu Ala Arg Glu Val Phe Glu Asn Thr Glu Lys Thr Met Glu Phe
65                  70                  75                  80  
Trp Lys Ile Tyr Ile Asp Gly Asp Gln Cys Asn Ser Asn Pro Cys Lys
                85                  90                  95      
Asn Gly Ala Val Cys Lys Asp Gly Val Ser Ser Tyr Glu Cys Met Cys
            100                 105                 110         
Pro Pro Gly Tyr Gly Gly Arg Asn Cys Glu Ile Asp Ser Thr Cys Ala
        115                 120                 125             
Thr Lys Asn Gly Gly Cys Glu His Phe Cys Arg His Asp Thr Pro Gln
    130                 135                 140                 
Lys Ala Val Cys Ser Cys Ala Ser Gly Tyr Lys Leu His Glu Asp Gly
145                 150                 155                 160 
Lys Ser Cys Lys Pro Ala Val Pro Tyr Pro Cys Gly Arg Ile Thr Ala
                165                 170                 175     
Pro Glu Met Arg Gly Lys Val Thr Arg Thr Glu Asn Thr Ile Glu Arg
            180                 185                 190         
Trp Asn Ile Thr Ala His Asp Glu Gly Asp Ala His Asp Glu Ala Leu
        195                 200                 205             
Asp Ile Thr Glu Pro Pro Pro Pro Pro Thr Thr Ser Ala Ala Pro Ala
    210                 215                 220                 
Lys Ile Val Pro Ile Thr Lys Asn Asp Thr Arg Val Val Gly Gly Tyr
225                 230                 235                 240 
Asp Ser Val Lys Gly Gln Leu Pro Trp Gln Val His Leu Val Asp Ser
                245                 250                 255     
Arg Gly Leu Gly Phe Cys Gly Gly Ser Ile Ile Asn Glu Lys Trp Val
            260                 265                 270         
Val Thr Ala Ala His Cys Leu Glu Pro Gly Asp Asn Val Thr Ala Val
        275                 280                 285             
Ala Gly Glu Tyr Asn Thr Lys Glu Asp Asp His Thr Glu Gln Arg Arg
    290                 295                 300                 
Gln Val Val Lys Ile Leu Pro Tyr Pro Thr Tyr Asn Arg Thr Arg Asn
305                 310                 315                 320 
Lys His His Asn Asp Ile Ala Leu Leu Glu Leu Asp Gln Pro Leu Thr
                325                 330                 335     
Phe Asn Ser Tyr Val Thr Pro Ile Cys Ile Gly Ser Arg Asp Phe Thr
            340                 345                 350         
Asn Asn Leu Leu Ser Asn Gly Pro Gly Thr Val Ser Gly Trp Gly Ser
        355                 360                 365             
Met Leu Tyr Arg Gly Arg Ser Ala Ile Val Leu Gln Val Leu Thr Val
    370                 375                 380                 
Pro Phe Val Asp Arg Val Thr Cys Leu Lys Ser Thr Ser Thr Thr Ile
385                 390                 395                 400 
Leu His Ser Met Phe Cys Ala Gly Tyr Thr Ala Gly Gly Lys Asp Thr
                405                 410                 415     
Cys Gly Gly Asp Ser Gly Gly Pro Tyr Thr Asn Ser Ile Gly Glu Thr
            420                 425                 430         
Trp Phe Leu Thr Gly Val Thr Ser Trp Gly Glu Glu Cys Ala Lys Pro
        435                 440                 445             
Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ala Lys Tyr Val Lys Trp Ile
    450                 455                 460                 
Arg Glu Thr Thr Arg Leu Thr
465                 470     


<210> 14
<211> 416
<212> PRT
<213> Bos taurus

<220> 
<223> Cow Factor IX

<400> 14
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Arg Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Lys Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Lys Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Met Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Gln Ala Gly Phe Glu Gly Thr
65                  70                  75                  80  
Asn Cys Glu Leu Asp Ala Thr Cys Ser Ile Lys Asn Gly Arg Cys Lys
                85                  90                  95      
Gln Phe Cys Lys Arg Asp Thr Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Asp Gly Tyr Arg Leu Ala Glu Asp Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser His Ile Ser Lys Lys Leu
    130                 135                 140                 
Thr Arg Ala Glu Thr Ile Phe Ser Asn Thr Asn Tyr Glu Asn Ser Ser
145                 150                 155                 160 
Glu Ala Glu Ile Ile Trp Asp Asn Val Thr Gln Ser Asn Gln Ser Phe
                165                 170                 175     
Asp Glu Phe Ser Arg Val Val Gly Gly Glu Asp Ala Glu Arg Gly Gln
            180                 185                 190         
Phe Pro Trp Gln Val Leu Leu His Gly Glu Ile Ala Ala Phe Cys Gly
        195                 200                 205             
Gly Ser Ile Val Asn Glu Lys Trp Val Val Thr Ala Ala His Cys Ile
    210                 215                 220                 
Lys Pro Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Thr Glu
225                 230                 235                 240 
Lys Pro Glu Pro Thr Glu Gln Lys Arg Asn Val Ile Arg Ala Ile Pro
                245                 250                 255     
Tyr His Ser Tyr Asn Ala Ser Ile Asn Lys Tyr Ser His Asp Ile Ala
            260                 265                 270         
Leu Leu Glu Leu Asp Glu Pro Leu Glu Leu Asn Ser Tyr Val Thr Pro
        275                 280                 285             
Ile Cys Ile Ala Asp Arg Asp Tyr Thr Asn Ile Phe Ser Lys Phe Gly
    290                 295                 300                 
Tyr Gly Tyr Val Ser Gly Trp Gly Lys Val Phe Asn Arg Gly Arg Ser
305                 310                 315                 320 
Ala Ser Ile Leu Gln Tyr Leu Lys Val Pro Leu Val Asp Arg Ala Thr
                325                 330                 335     
Cys Leu Arg Ser Thr Lys Phe Ser Ile Tyr Ser His Met Phe Cys Ala
            340                 345                 350         
Gly Tyr His Glu Gly Gly Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly
        355                 360                 365             
Pro His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile
    370                 375                 380                 
Ser Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr
385                 390                 395                 400 
Lys Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415     


<210> 15
<211> 274
<212> PRT
<213> Ovis aries

<220> 
<223> Sheep Factor IX

<400> 15
Arg Ala Ser Val Leu His Thr Ser Lys Lys Leu Thr Arg Ala Glu Thr
 1               5                  10                  15      
Ile Phe Ser Asn Met Asn Tyr Glu Asn Ser Ser Glu Ala Glu Ile Ile
            20                  25                  30          
Trp Asp Asn Val Thr Gln Ser Asn Gln Ser Phe Asp Asp Phe Asn Arg
        35                  40                  45              
Val Val Gly Gly Glu Asp Ala Ala Arg Gly Gln Phe Pro Trp Gln Val
    50                  55                  60                  
Leu Leu His Gly Glu Ile Ala Ala Phe Cys Gly Gly Ser Ile Val Asn
65                  70                  75                  80  
Glu Lys Trp Val Val Thr Ala Ala His Cys Ile Lys Pro Gly Val Lys
                85                  90                  95      
Ile Thr Val Val Ala Gly Glu His Asn Thr Glu Lys Pro Glu Pro Thr
            100                 105                 110         
Glu Gln Lys Arg Asn Val Ile Arg Ala Ile Pro Tyr His Gly Tyr Asn
        115                 120                 125             
Ala Ser Ile Asn Lys Tyr Ser His Asp Ile Ala Leu Leu Glu Leu Asp
    130                 135                 140                 
Glu Pro Leu Glu Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile Ala Asp
145                 150                 155                 160 
Arg Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Tyr Gly Tyr Val Ser
                165                 170                 175     
Gly Trp Gly Arg Val Phe Asn Arg Gly Arg Ser Ala Ser Ile Leu Gln
            180                 185                 190         
Tyr Leu Lys Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg Ser Thr
        195                 200                 205             
Lys Phe Thr Ile Tyr Asn His Met Phe Cys Ala Gly Tyr His Glu Gly
    210                 215                 220                 
Gly Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Glu
225                 230                 235                 240 
Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly Glu Glu
                245                 250                 255     
Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser Arg Tyr
            260                 265                 270         
Glu Val
        


<210> 16
<211> 463
<212> PRT
<213> Xenopus tropicalis

<220> 
<223> Frog Factor IX

<400> 16
Met Val Ala Phe Ser Ser Ile Leu Ile Ile Tyr Leu Leu Thr Ser Leu
 1               5                  10                  15      
Cys Ser Thr Glu Lys Ala Val Phe Leu Ser Asp Glu Ser Ala Ser Ser
            20                  25                  30          
Leu Leu Val Arg Gln Lys Arg Tyr Asn Thr Gly Arg Leu Glu Glu Trp
        35                  40                  45              
Val Ala Gly Asn Leu Glu Arg Glu Cys Leu Glu Glu Lys Cys Asn Tyr
    50                  55                  60                  
Glu Glu Ala Arg Glu Val Phe Glu Asn Asp Asp Lys Thr Lys Glu Phe
65                  70                  75                  80  
Trp Lys Gln Tyr Ile Asp Gly Asp Gln Cys Leu Ser Asn Pro Cys Leu
                85                  90                  95      
Asn Gly Gly Val Cys Lys Asp Asp Val Ser Asp Tyr Val Cys Trp Cys
            100                 105                 110         
Gln Gln Gly Tyr Ser Gly Lys Asn Cys Glu Leu Glu Leu Pro Val Ile
        115                 120                 125             
Cys Ser Ile Met Asn Gly Gly Cys Asp His Met Cys Arg Asp Asp Pro
    130                 135                 140                 
Val Lys Lys Val Ile Cys Ser Cys Ala Ser Gly Tyr Lys Leu Ala Glu
145                 150                 155                 160 
Asn Gly Lys Thr Cys Glu Ala Ala Val Pro Tyr Pro Cys Gly Arg Val
                165                 170                 175     
Ser Ser Pro Glu Ala Leu Pro Lys Glu Glu Thr Arg Ser Phe Leu Asp
            180                 185                 190         
Ser Leu Glu Gln Asn Leu Thr Ser Ala Ala His Pro Asn Ile Thr Asp
        195                 200                 205             
Gln Glu Lys Pro Lys Glu Asp Ile Val Pro Val Thr Val Asp Pro Asn
    210                 215                 220                 
Val Arg Ile Val Gly Gly Thr Asp Ser Leu Lys Gly Glu Phe Pro Trp
225                 230                 235                 240 
Gln Val His Leu Val Asn Lys Asp Asn Leu Gly Phe Cys Ser Gly Ser
                245                 250                 255     
Ile Ile Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Phe Leu Ile
            260                 265                 270         
Arg Gly Glu Phe Lys Val Val Ala Gly Glu His Asn Thr Glu Val Ser
        275                 280                 285             
Asp Gly Thr Glu Gln His His Lys Val Thr Arg Ile Ile Leu Tyr Pro
    290                 295                 300                 
Ala Tyr Asn Ala Thr Arg Ser Lys Tyr Asn Asn Asp Ile Ala Leu Leu
305                 310                 315                 320 
Glu Leu Glu Lys Pro Leu Glu Leu Asn Asp Tyr Val Arg Pro Val Cys
                325                 330                 335     
Ile Gly Asn Met Asp Phe Thr Glu Lys Leu Leu Lys Arg Asn Ala Phe
            340                 345                 350         
Ser Met Val Ser Gly Trp Gly Asp Leu Gly Tyr Lys Gly Arg Pro Ala
        355                 360                 365             
Val Ile Leu Gln Lys Leu Ala Val Pro Tyr Ile Asn Gln Ala Ala Cys
    370                 375                 380                 
Lys Lys Ser Ser Arg Phe Ser Ile Tyr Ala Asn Met Phe Cys Ala Gly
385                 390                 395                 400 
Tyr Ser Asp Glu Ser Lys Asp Thr Cys Gln Gly Asp Ser Gly Gly Pro
                405                 410                 415     
His Val Thr Glu Tyr Lys Asn Leu Trp Phe Leu Thr Gly Ile Thr Ser
            420                 425                 430         
Trp Gly Glu Lys Cys Ala Glu Lys Asp Lys Tyr Gly Val Tyr Thr Arg
        435                 440                 445             
Leu Ser Arg Phe Thr Asp Trp Ile Arg Thr Thr Thr Lys Ile Ser
    450                 455                 460             


<210> 17
<211> 503
<212> PRT
<213> Danio rerio

<220> 
<223> Zebrafish Factor IX

<400> 17
Met Ala Ser Phe Ile Leu Val Leu Phe Pro Phe Leu Leu Leu Gln Ala
 1               5                  10                  15      
Ala Leu Gly Ser Val Phe Leu Asp Gly Glu Lys Ala Asp Ser Val Leu
            20                  25                  30          
Trp Arg Arg Arg Arg Ala Asn Thr Trp Leu Phe Glu Glu Phe Leu Pro
        35                  40                  45              
Gly Asn Val Glu Arg Glu Cys Ile Glu Glu Lys Cys Val Leu Glu Glu
    50                  55                  60                  
Ala Arg Glu Ala Phe Glu Asn Asp Glu Lys Thr Met Glu Phe Trp Ala
65                  70                  75                  80  
Ser Tyr Val Asp Gly Asn Gln Cys Lys Pro Ser Pro Cys Gln Asn Gln
                85                  90                  95      
Gly Thr Cys Glu Asp Gln Met Gly Thr Tyr Ser Cys Asn Cys Leu Ala
            100                 105                 110         
Arg Phe Cys Trp Gln Asn Cys Glu Ile Val Thr Ala Lys Lys Cys Asp
        115                 120                 125             
Val Asp Asn Gly Gly Cys Glu His Phe Cys Val Leu Leu Glu Ser His
    130                 135                 140                 
Lys Thr Gln Cys Arg Val His Met Asp Thr Asn Ser Gln Lys Met Asp
145                 150                 155                 160 
Phe Thr Cys Glu Pro Ile Val Lys Phe Pro Cys Gly Lys Thr Ser Lys
                165                 170                 175     
Pro Ala Val Lys Thr Phe Gly Thr Ala Ser Val Thr Asn Thr Thr Ala
            180                 185                 190         
Gln Ser Ser Asn Lys Thr Ile Lys Ser Thr Ser Ser Ile Pro Lys Pro
        195                 200                 205             
Asp Asn Leu Thr Asn Pro Thr Asn Ser Lys Asp Ile Lys Glu Lys Leu
    210                 215                 220                 
Ala Pro Pro Arg Ala Lys Leu Pro Lys Trp Ala Phe Glu Glu Tyr Leu
225                 230                 235                 240 
Thr Ser Pro Ala Pro Thr Val Ser Gly Leu Lys Ser Arg Ile Ile Gly
                245                 250                 255     
Gly Asn Ser Ala Leu Pro Gly Glu Ile Pro Trp Gln Val Ala Leu Val
            260                 265                 270         
Ser Arg Ser Thr Gln Gln Val Phe Cys Gly Gly Ser Ile Leu Asn Pro
        275                 280                 285             
Leu Trp Val Ile Thr Ala Ala His Cys Leu Leu Gly Asn His Asn Gly
    290                 295                 300                 
Ser Phe Tyr Ile Arg Val Gly Glu His Asp Val Ser Lys Ile Glu Gly
305                 310                 315                 320 
Thr Glu Gln Asn Val Asp Val Ile Lys Leu Ile Ser His Pro Arg Tyr
                325                 330                 335     
Asn Ser Lys Val Ser Leu Phe Asn His Asp Ile Ala Leu Leu Arg Leu
            340                 345                 350         
Arg Ser Pro Ile Arg Leu Thr Pro Thr Val Arg Pro Ile Cys Leu Gly
        355                 360                 365             
Pro Met Val Phe Ser Asn Thr Leu Leu Gln Ser Gly Thr Leu Ala Thr
    370                 375                 380                 
Val Ser Gly Trp Gly Arg Val Arg Phe Gln Gly Arg Ser Ala Ala Thr
385                 390                 395                 400 
Leu Gln Lys Ile Glu Leu Pro Tyr Val Asp Arg Thr Val Cys Lys Glu
                405                 410                 415     
Ser Ser Ser Asp Pro Ile Thr His Phe Met Phe Cys Ala Gly His Ser
            420                 425                 430         
Asp Ser Pro Lys Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His Val
        435                 440                 445             
Met Arg Tyr His Asn Thr Trp Phe Leu Thr Gly Ile Ile Ser Trp Gly
    450                 455                 460                 
Glu Glu Cys Ala Lys Lys Gly Lys Tyr Gly Val Tyr Thr Gln Val Gly
465                 470                 475                 480 
Asn Tyr Tyr Arg Trp Ile Gln His Thr Met Gly Val Thr Thr Gly Ala
                485                 490                 495     
Leu Leu Thr Asn Val Asp Gln
            500             


<210> 18
<211> 537
<212> PRT
<213> Takifugu rubripes

<220> 
<223> Japanese pufferfish Factor IX

<400> 18
Met Ala Arg Asp Phe Leu Leu Ala Leu Ile Ala Ala Leu Leu Leu Glu
 1               5                  10                  15      
Val Ser Gly Leu Pro Thr Glu Gly Ser Thr Gly Gly Val Phe Val Ser
            20                  25                  30          
Pro Gln Ala Ala Asn Met Val Leu Leu Arg Gln Arg Arg Tyr Asn Ser
        35                  40                  45              
Gly His Leu Glu Glu Leu Gln Lys Asp Asn Leu Glu Arg Glu Cys Lys
    50                  55                  60                  
Glu Glu Gln Cys Thr Met Glu Glu Ala Arg Glu Val Phe Glu Asp Asp
65                  70                  75                  80  
Glu Lys Thr Ala Glu Phe Trp Val Gly Tyr Ile Asp Gly Asp Gln Cys
                85                  90                  95      
Val Pro Pro Pro Cys Gln Asn Glu Gly Val Cys Lys Asp Gly Ile Asn
            100                 105                 110         
Ser Tyr Val Cys Trp Cys Lys Pro Asp Phe Ser Gly Arg Asn Cys Glu
        115                 120                 125             
Ile Glu Val Ser Lys Gln Cys Ser Val Asn Asn Gly Gly Cys Ser His
    130                 135                 140                 
Phe Cys Val Met Gln Gly Asp Ile Ser Val Cys His Cys Ala Val Gly
145                 150                 155                 160 
His Arg Leu Gly Leu Asp Lys Lys Ser Cys Glu Pro Thr Asp Gln Phe
                165                 170                 175     
Ser Cys Gly His Ile Asn Met Ser Phe Ser Ser Lys Ser Asn Val Gln
            180                 185                 190         
Arg Arg Ser Leu Met Gln Lys Leu Glu Ala Asn Arg Thr Phe Ser Ser
        195                 200                 205             
Ile Leu Leu Gly Asp Tyr Ser Asp Asn Ser Thr Glu Leu Tyr Asp Tyr
    210                 215                 220                 
Ile Glu Ser Met Asp Trp Ala Pro Pro Asn Thr Thr Met Ile Asp Pro
225                 230                 235                 240 
Arg Ser Gly Arg Thr Ser Ser Val Gly Pro Asp Gln Asn Arg Ser Ser
                245                 250                 255     
Leu Thr Glu Asp Leu Ile Ser Val Ser Glu Thr Glu Ile Pro Tyr Trp
            260                 265                 270         
Ala Phe Pro Thr Leu Pro Thr Ile Pro Glu Lys Glu Asn Thr Asp Gln
        275                 280                 285             
Arg Ile Val Gly Gly Asp Glu Ala Leu Pro Gly Glu Ile Pro Trp Gln
    290                 295                 300                 
Val Thr Leu Met Ser His Ser Val Ile Leu Gln Arg Ala Glu Pro Phe
305                 310                 315                 320 
Cys Gly Gly Ser Leu Phe Ser Asp Leu Trp Val Ile Thr Ala Ala His
                325                 330                 335     
Cys Leu Ile Asn Glu Lys Ile Ala Lys Gln Gly Ile Leu His Ser Ser
            340                 345                 350         
Arg Glu His Asp Val Ser Lys Asp Glu Gly Pro Glu Arg Asp His Thr
        355                 360                 365             
Val Ala Glu Gln His Ile His Phe Met Tyr Asp Tyr Lys Lys Ser Pro
    370                 375                 380                 
Tyr Asn His Asp Ile Ala Leu Leu Lys Leu Asn Lys Pro Val Glu Leu
385                 390                 395                 400 
Ser Asn Lys Arg Arg Pro Ile Cys Leu Gly Pro Lys Asp Phe Thr Glu
                405                 410                 415     
Thr Leu Leu Arg Glu Ser Thr Ser Ser Leu Val Ser Gly Trp Gly Arg
            420                 425                 430         
Ile Lys Phe Phe Gly Leu Glu Ala Thr Lys Leu Gln Lys Leu Glu Val
        435                 440                 445             
Pro Tyr Val Asp Arg Thr Arg Cys Lys Gln Ser Ser Arg Glu Gln Val
    450                 455                 460                 
Thr Arg Tyr Met Phe Cys Ala Gly Tyr Gln Leu Gln Ala Lys Asp Ser
465                 470                 475                 480 
Cys Gln Gly Asp Ser Gly Gly Pro His Ala Thr Lys Tyr Lys Asp Thr
                485                 490                 495     
Trp Phe Leu Thr Gly Ile Val Ser Trp Gly Glu Glu Cys Ala Lys Asp
            500                 505                 510         
Gly Lys Tyr Gly Ile Tyr Thr Arg Val Ser Arg Tyr Tyr Pro Trp Ile
        515                 520                 525             
Ser Gln Lys Thr Gly Leu Gln Met Ser
    530                 535         


<210> 19
<211> 245
<212> PRT
<213> Bos taurus

<220> 
<223> Mature chymotrypsin

<400> 19
Cys Gly Val Pro Ala Ile Gln Pro Val Leu Ser Gly Leu Ser Arg Ile
 1               5                  10                  15      
Val Asn Gly Glu Glu Ala Val Pro Gly Ser Trp Pro Trp Gln Val Ser
            20                  25                  30          
Leu Gln Asp Lys Thr Gly Phe His Phe Cys Gly Gly Ser Leu Ile Asn
        35                  40                  45              
Glu Asn Trp Val Val Thr Ala Ala His Cys Gly Val Thr Thr Ser Asp
    50                  55                  60                  
Val Val Val Ala Gly Glu Phe Asp Gln Gly Ser Ser Ser Glu Lys Ile
65                  70                  75                  80  
Gln Lys Leu Lys Ile Ala Lys Val Phe Lys Asn Ser Lys Tyr Asn Ser
                85                  90                  95      
Leu Thr Ile Asn Asn Asp Ile Thr Leu Leu Lys Leu Ser Thr Ala Ala
            100                 105                 110         
Ser Phe Ser Gln Thr Val Ser Ala Val Cys Leu Pro Ser Ala Ser Asp
        115                 120                 125             
Asp Phe Ala Ala Gly Thr Thr Cys Val Thr Thr Gly Trp Gly Leu Thr
    130                 135                 140                 
Arg Tyr Thr Asn Ala Asn Thr Pro Asp Arg Leu Gln Gln Ala Ser Leu
145                 150                 155                 160 
Pro Leu Leu Ser Asn Thr Asn Cys Lys Lys Tyr Trp Gly Thr Lys Ile
                165                 170                 175     
Lys Asp Ala Met Ile Cys Ala Gly Ala Ser Gly Val Ser Ser Cys Met
            180                 185                 190         
Gly Asp Ser Gly Gly Pro Leu Val Cys Lys Lys Asn Gly Ala Trp Thr
        195                 200                 205             
Leu Val Gly Ile Val Ser Trp Gly Ser Ser Thr Cys Ser Thr Ser Thr
    210                 215                 220                 
Pro Gly Val Tyr Ala Arg Val Thr Ala Leu Val Asn Trp Val Gln Gln
225                 230                 235                 240 
Thr Leu Ala Ala Asn
                245 


<210> 20
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> BeneFIX, recombinant Factor IX

<400> 20
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Ala Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 21
<211> 464
<212> PRT
<213> Homo sapiens

<220> 
<223> Antithrombin III

<400> 21
Met Tyr Ser Asn Val Ile Gly Thr Val Thr Ser Gly Lys Arg Lys Val
 1               5                  10                  15      
Tyr Leu Leu Ser Leu Leu Leu Ile Gly Phe Trp Asp Cys Val Thr Cys
            20                  25                  30          
His Gly Ser Pro Val Asp Ile Cys Thr Ala Lys Pro Arg Asp Ile Pro
        35                  40                  45              
Met Asn Pro Met Cys Ile Tyr Arg Ser Pro Glu Lys Lys Ala Thr Glu
    50                  55                  60                  
Asp Glu Gly Ser Glu Gln Lys Ile Pro Glu Ala Thr Asn Arg Arg Val
65                  70                  75                  80  
Trp Glu Leu Ser Lys Ala Asn Ser Arg Phe Ala Thr Thr Phe Tyr Gln
                85                  90                  95      
His Leu Ala Asp Ser Lys Asn Asp Asn Asp Asn Ile Phe Leu Ser Pro
            100                 105                 110         
Leu Ser Ile Ser Thr Ala Phe Ala Met Thr Lys Leu Gly Ala Cys Asn
        115                 120                 125             
Asp Thr Leu Gln Gln Leu Met Glu Val Phe Lys Phe Asp Thr Ile Ser
    130                 135                 140                 
Glu Lys Thr Ser Asp Gln Ile His Phe Phe Phe Ala Lys Leu Asn Cys
145                 150                 155                 160 
Arg Leu Tyr Arg Lys Ala Asn Lys Ser Ser Lys Leu Val Ser Ala Asn
                165                 170                 175     
Arg Leu Phe Gly Asp Lys Ser Leu Thr Phe Asn Glu Thr Tyr Gln Asp
            180                 185                 190         
Ile Ser Glu Leu Val Tyr Gly Ala Lys Leu Gln Pro Leu Asp Phe Lys
        195                 200                 205             
Glu Asn Ala Glu Gln Ser Arg Ala Ala Ile Asn Lys Trp Val Ser Asn
    210                 215                 220                 
Lys Thr Glu Gly Arg Ile Thr Asp Val Ile Pro Ser Glu Ala Ile Asn
225                 230                 235                 240 
Glu Leu Thr Val Leu Val Leu Val Asn Thr Ile Tyr Phe Lys Gly Leu
                245                 250                 255     
Trp Lys Ser Lys Phe Ser Pro Glu Asn Thr Arg Lys Glu Leu Phe Tyr
            260                 265                 270         
Lys Ala Asp Gly Glu Ser Cys Ser Ala Ser Met Met Tyr Gln Glu Gly
        275                 280                 285             
Lys Phe Arg Tyr Arg Arg Val Ala Glu Gly Thr Gln Val Leu Glu Leu
    290                 295                 300                 
Pro Phe Lys Gly Asp Asp Ile Thr Met Val Leu Ile Leu Pro Lys Pro
305                 310                 315                 320 
Glu Lys Ser Leu Ala Lys Val Glu Lys Glu Leu Thr Pro Glu Val Leu
                325                 330                 335     
Gln Glu Trp Leu Asp Glu Leu Glu Glu Met Met Leu Val Val His Met
            340                 345                 350         
Pro Arg Phe Arg Ile Glu Asp Gly Phe Ser Leu Lys Glu Gln Leu Gln
        355                 360                 365             
Asp Met Gly Leu Val Asp Leu Phe Ser Pro Glu Lys Ser Lys Leu Pro
    370                 375                 380                 
Gly Ile Val Ala Glu Gly Arg Asp Asp Leu Tyr Val Ser Asp Ala Phe
385                 390                 395                 400 
His Lys Ala Phe Leu Glu Val Asn Glu Glu Gly Ser Glu Ala Ala Ala
                405                 410                 415     
Ser Thr Ala Val Val Ile Ala Gly Arg Ser Leu Asn Pro Asn Arg Val
            420                 425                 430         
Thr Phe Lys Ala Asn Arg Pro Phe Leu Val Phe Ile Arg Glu Val Pro
        435                 440                 445             
Leu Asn Thr Ile Ile Phe Met Gly Arg Val Ala Asn Pro Cys Val Lys
    450                 455                 460                 


<210> 22
<211> 432
<212> PRT
<213> Homo sapiens

<220> 
<223> Cleaved Antithrombin III  (33-464)

<400> 22
His Gly Ser Pro Val Asp Ile Cys Thr Ala Lys Pro Arg Asp Ile Pro
 1               5                  10                  15      
Met Asn Pro Met Cys Ile Tyr Arg Ser Pro Glu Lys Lys Ala Thr Glu
            20                  25                  30          
Asp Glu Gly Ser Glu Gln Lys Ile Pro Glu Ala Thr Asn Arg Arg Val
        35                  40                  45              
Trp Glu Leu Ser Lys Ala Asn Ser Arg Phe Ala Thr Thr Phe Tyr Gln
    50                  55                  60                  
His Leu Ala Asp Ser Lys Asn Asp Asn Asp Asn Ile Phe Leu Ser Pro
65                  70                  75                  80  
Leu Ser Ile Ser Thr Ala Phe Ala Met Thr Lys Leu Gly Ala Cys Asn
                85                  90                  95      
Asp Thr Leu Gln Gln Leu Met Glu Val Phe Lys Phe Asp Thr Ile Ser
            100                 105                 110         
Glu Lys Thr Ser Asp Gln Ile His Phe Phe Phe Ala Lys Leu Asn Cys
        115                 120                 125             
Arg Leu Tyr Arg Lys Ala Asn Lys Ser Ser Lys Leu Val Ser Ala Asn
    130                 135                 140                 
Arg Leu Phe Gly Asp Lys Ser Leu Thr Phe Asn Glu Thr Tyr Gln Asp
145                 150                 155                 160 
Ile Ser Glu Leu Val Tyr Gly Ala Lys Leu Gln Pro Leu Asp Phe Lys
                165                 170                 175     
Glu Asn Ala Glu Gln Ser Arg Ala Ala Ile Asn Lys Trp Val Ser Asn
            180                 185                 190         
Lys Thr Glu Gly Arg Ile Thr Asp Val Ile Pro Ser Glu Ala Ile Asn
        195                 200                 205             
Glu Leu Thr Val Leu Val Leu Val Asn Thr Ile Tyr Phe Lys Gly Leu
    210                 215                 220                 
Trp Lys Ser Lys Phe Ser Pro Glu Asn Thr Arg Lys Glu Leu Phe Tyr
225                 230                 235                 240 
Lys Ala Asp Gly Glu Ser Cys Ser Ala Ser Met Met Tyr Gln Glu Gly
                245                 250                 255     
Lys Phe Arg Tyr Arg Arg Val Ala Glu Gly Thr Gln Val Leu Glu Leu
            260                 265                 270         
Pro Phe Lys Gly Asp Asp Ile Thr Met Val Leu Ile Leu Pro Lys Pro
        275                 280                 285             
Glu Lys Ser Leu Ala Lys Val Glu Lys Glu Leu Thr Pro Glu Val Leu
    290                 295                 300                 
Gln Glu Trp Leu Asp Glu Leu Glu Glu Met Met Leu Val Val His Met
305                 310                 315                 320 
Pro Arg Phe Arg Ile Glu Asp Gly Phe Ser Leu Lys Glu Gln Leu Gln
                325                 330                 335     
Asp Met Gly Leu Val Asp Leu Phe Ser Pro Glu Lys Ser Lys Leu Pro
            340                 345                 350         
Gly Ile Val Ala Glu Gly Arg Asp Asp Leu Tyr Val Ser Asp Ala Phe
        355                 360                 365             
His Lys Ala Phe Leu Glu Val Asn Glu Glu Gly Ser Glu Ala Ala Ala
    370                 375                 380                 
Ser Thr Ala Val Val Ile Ala Gly Arg Ser Leu Asn Pro Asn Arg Val
385                 390                 395                 400 
Thr Phe Lys Ala Asn Arg Pro Phe Leu Val Phe Ile Arg Glu Val Pro
                405                 410                 415     
Leu Asn Thr Ile Ile Phe Met Gly Arg Val Ala Asn Pro Cys Val Lys
            420                 425                 430         


<210> 23
<211> 4194
<212> DNA
<213> Artificial Sequence

<220> 
<223> pFUSE-hIgG1-Fc2 vector

<400> 23
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg 60
agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa 120
actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt 180
atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac 240
agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc 300
gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg 360
cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc 420
cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac 480
tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc 540
ctacctgaga tcaccggcga aggagggcca ccatgtacag gatgcaactc ctgtcttgca 600
ttgcactaag tcttgcactt gtcacgaatt cgatatcggc catggttaga tctgacaaaa 660
ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca gtcttcctct 720
tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc acatgcgtgg 780
tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg 840
aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg taccgtgtgg 900
tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac aagtgcaagg 960
tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc aaagggcagc 1020
cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc aagaaccagg 1080
tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg gagtgggaga 1140
gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac tccgacggct 1200
ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag gggaacgtct 1260
tctcatgctc cgtgatgcac gaggctctgc acaaccacta cacgcagaag agcctctccc 1320
tgtctccggg taaatgagtg ctagctggcc agacatgata agatacattg atgagtttgg 1380
acaaaccaca actagaatgc agtgaaaaaa atgctttatt tgtgaaattt gtgatgctat 1440
tgctttattt gtaaccatta taagctgcaa taaacaagtt aacaacaaca attgcattca 1500
ttttatgttt caggttcagg gggaggtgtg ggaggttttt taaagcaagt aaaacctcta 1560
caaatgtggt atggaattaa ttctaaaata cagcatagca aaactttaac ctccaaatca 1620
agcctctact tgaatccttt tctgagggat gaataaggca taggcatcag gggctgttgc 1680
caatgtgcat tagctgtttg cagcctcacc ttctttcatg gagtttaaga tatagtgtat 1740
tttcccaagg tttgaactag ctcttcattt ctttatgttt taaatgcact gacctcccac 1800
attccctttt tagtaaaata ttcagaaata atttaaatac atcattgcaa tgaaaataaa 1860
tgttttttat taggcagaat ccagatgctc aaggcccttc ataatatccc ccagtttagt 1920
agttggactt agggaacaaa ggaaccttta atagaaattg gacagcaaga aagcgagctt 1980
ctagcttatc ctcagtcctg ctcctctgcc acaaagtgca cgcagttgcc ggccgggtcg 2040
cgcagggcga actcccgccc ccacggctgc tcgccgatct cggtcatggc cggcccggag 2100
gcgtcccgga agttcgtgga cacgacctcc gaccactcgg cgtacagctc gtccaggccg 2160
cgcacccaca cccaggccag ggtgttgtcc ggcaccacct ggtcctggac cgcgctgatg 2220
aacagggtca cgtcgtcccg gaccacaccg gcgaagtcgt cctccacgaa gtcccgggag 2280
aacccgagcc ggtcggtcca gaactcgacc gctccggcga cgtcgcgcgc ggtgagcacc 2340
ggaacggcac tggtcaactt ggccatgatg gctcctcctg tcaggagagg aaagagaaga 2400
aggttagtac aattgctata gtgagttgta ttatactatg cagatatact atgccaatga 2460
ttaattgtca aactagggct gcagggttca tagtgccact tttcctgcac tgccccatct 2520
cctgcccacc ctttcccagg catagacagt cagtgactta ccaaactcac aggagggaga 2580
aggcagaagc ttgagacaga cccgcgggac cgccgaactg cgaggggacg tggctagggc 2640
ggcttctttt atggtgcgcc ggccctcgga ggcagggcgc tcggggaggc ctagcggcca 2700
atctgcggtg gcaggaggcg gggccgaagg ccgtgcctga ccaatccgga gcacatagga 2760
gtctcagccc cccgccccaa agcaagggga agtcacgcgc ctgtagcgcc agcgtgttgt 2820
gaaatggggg cttggggggg ttggggccct gactagtcaa aacaaactcc cattgacgtc 2880
aatggggtgg agacttggaa atccccgtga gtcaaaccgc tatccacgcc cattgatgta 2940
ctgccaaaac cgcatcatca tggtaatagc gatgactaat acgtagatgt actgccaagt 3000
aggaaagtcc cataaggtca tgtactgggc ataatgccag gcgggccatt taccgtcatt 3060
gacgtcaata gggggcgtac ttggcatatg atacacttga tgtactgcca agtgggcagt 3120
ttaccgtaaa tactccaccc attgacgtca atggaaagtc cctattggcg ttactatggg 3180
aacatacgtc attattgacg tcaatgggcg ggggtcgttg ggcggtcagc caggcgggcc 3240
atttaccgta agttatgtaa cgcctgcagg ttaattaaga acatgtgagc aaaaggccag 3300
caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag gctccgcccc 3360
cctgacgagc atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta 3420
taaagatacc aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg 3480
ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc 3540
tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac 3600
gaaccccccg ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac 3660
ccggtaagac acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg 3720
aggtatgtag gcggtgctac agagttcttg aagtggtggc ctaactacgg ctacactaga 3780
agaacagtat ttggtatctg cgctctgctg aagccagtta ccttcggaaa aagagttggt 3840
agctcttgat ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag 3900
cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct 3960
gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatggctag ttaattaaca 4020
tttaaatcag cggccgcaat aaaatatctt tattttcatt acatctgtgt gttggttttt 4080
tgtgtgaatc gtaactaaca tacgctctcc atcaaaacaa aacgaaacaa aacaaactag 4140
caaaataggc tgtccccagt gcaagtgcag gtgccagaac atttctctat cgaa       4194

<210> 24
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> pFUSE-Acc-F1 forward primer

<400> 24
gtgctagctg gccagacatg ataag                                       25

<210> 25
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> pFUSE-Acc-R3 reverse primer

<400> 25
catggtggcc ctccttcgcc ggtgatc                                     27

<210> 26
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Factor IX-wtsp-Invivo-F1 forward primer

<400> 26
cgaaggaggg ccaccatgca gcgcgtgaac atgatc                           36

<210> 27
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> Factor IX-Invivo-R1 reverse primer

<400> 27
tgtctggcca gctagcactt aagtgagctt tgttttttcc                       40

<210> 28
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-A[103]N/N[105]S-For

<400> 28
gtaaaaatag taatgatagc aaggtggttt g                                31

<210> 29
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-D[104]N/K[106]S-For

<400> 29
gtaaaaatag tgctaataac agtgtggttt gctcctgtac tg                    42

<210> 30
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-K[106]N/V[108]S-For

<400> 30
gtgctgataa caatgtgagt tgctcctgta ctg                              33

<210> 31
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-D[85]N-For

<400> 31
gaactgtgaa ttaaatgtaa catgtaac                                    28

<210> 32
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-T[148]A-For

<400> 32
ctcacccgtg ctgaggctgt ttttcctgat gtg                              33

<210> 33
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-D39N/F41T-For

<400> 33
gaatggtaaa gttaatgcaa cctgtggagg ctctatc                          37

<210> 34
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-K63N-For

<400> 34
gaaactggtg ttaacattac agttgtcgc                                   29

<210> 35
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-I86S-For

<400> 35
gcgaaatgtg agtcgaatta ttcctc                                      26

<210> 36
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-A95bS-For

<400> 36
caactacaat gcaagtatta ataagtacaa c                                31

<210> 37
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-K243N-For

<400> 37
aaggaaaaaa caaatctcac ttaagtgcta gctg                             34

<210> 38
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-E240N-For

<400> 38
ctggattaag aataaaacaa agctc                                       25

<210> 39
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-E74N-For

<400> 39
caggtgaaca taatattaac gagacagaac atacag                           36

<210> 40
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-T76N/H78S-For

<400> 40
gaacataata ttgaggagaa cgaaagtaca gagcaaaag                        39

<210> 41
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-K82N/N84S-For

<400> 41
cagaacatac agagcaaaat cgatctgtga ttcgaattat tc                    42

<210> 42
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-L153N-For

<400> 42
gggagatcag ctaatgttct tcagtac                                     27

<210> 43
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-F145N/H147S-For

<400> 43
ctggggaaga gtcaactcca aagggagatc ag                               32

<210> 44
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-K222N/K224S-For

<400> 44
gagtgtgcaa tgaacggctc atatggaata tatac                            35

<210> 45
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-S151N/L153S-For

<400> 45
cttccacaaa gggagaaatg cttcagttct tca                              33

<210> 46
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-N95S-For

<400> 46
cctcaccaca actacagtgc agctattaat aagtacaacc                       40

<210> 47
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-Y117N-For

<400> 47
cttagtgcta aacagcaacg ttacacctat ttgc                             34

<210> 48
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-G149N-For

<400> 48
ggaagagtct tccacaaaaa cagatcagct ttagttc                          37

<210> 49
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-R150N/A152S-For

<400> 49
gtcttccaca aagggaactc atctttagtt cttcagtac                        39

<210> 50
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-R150A-For

<400> 50
gtcttccaca aaggggcatc agctttagtt cttcag                           36

<210> 51
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-R150E-For

<400> 51
gtcttccaca aaggggaatc agctttagtt cttcag                           36

<210> 52
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-R150Y-For

<400> 52
gtcttccaca aagggtactc agctttagtt cttcag                           36

<210> 53
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-R143Q-For

<400> 53
gtaagtggct ggggacaagt cttccacaaa ggg                              33

<210> 54
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-R143A-For

<400> 54
gtaagtggct ggggagcagt cttccacaaa ggg                              33

<210> 55
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-R143Y-For

<400> 55
gtaagtggct ggggatacgt cttccacaaa ggg                              33

<210> 56
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-R143L-For

<400> 56
gtaagtggct ggggactggt cttccacaaa ggg                              33

<210> 57
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-V38M-For

<400> 57
gttttgaatg gtaaaatgga tgcattctgt ggaggc                           36

<210> 58
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-V38Y-For

<400> 58
gttttgaatg gtaaatacga tgcattctgt ggaggc                           36

<210> 59
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-D39M-For

<400> 59
gttttgaatg gtaaagttat ggcattctgt ggaggc                           36

<210> 60
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-D39Y-For

<400> 60
gttttgaatg gtaaagttta cgcattctgt ggaggc                           36

<210> 61
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-A40M-For

<400> 61
gttttgaatg gtaaagttga tatgttctgt ggaggctcta tc                    42

<210> 62
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-A40Y-For

<400> 62
gttttgaatg gtaaagttga ttacttctgt ggaggctcta tc                    42

<210> 63
<211> 49
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-R233A/K230A-For

<400> 63
caaatatgga atatataccg cagtatccgc atatgtcaac tggattaag             49

<210> 64
<211> 49
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-R233E/K230E-For

<400> 64
caaatatgga atatataccg aagtatccga atatgtcaac tggattaag             49

<210> 65
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-R233A-For

<400> 65
gaatatatac caaggtatcc gcatatgtca actggattaa g                     41

<210> 66
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-R233E-For

<400> 66
gaatatatac caaggtatcc gaatatgtca actggattaa g                     41

<210> 67
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-K230A-For

<400> 67
caaatatgga atatataccg cagtatcccg gtatgtc                          37

<210> 68
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-K230E-For

<400> 68
caaatatgga atatataccg aagtatcccg gtatgtc                          37

<210> 69
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-K126E-For

<400> 69
cctatttgca ttgctgacga agaatacacg aacatc                           36

<210> 70
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-K126A-For

<400> 70
cctatttgca ttgctgacgc agaatacacg aacatc                           36

<210> 71
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-R165A-For

<400> 71
gttccacttg ttgacgcagc cacatgtctt cgatct                           36

<210> 72
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-R165E-For

<400> 72
gttccacttg ttgacgaagc cacatgtctt cgatct                           36

<210> 73
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-R170A-For

<400> 73
cgagccacat gtcttgcatc tacaaagttc acc                              33

<210> 74
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-R170E-For

<400> 74
cgagccacat gtcttgaatc tacaaagttc acc                              33

<210> 75
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX N157D

<400> 75
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asp Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 76
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F

<400> 76
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 77
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX A103N/N105S

<400> 77
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Asn Asp Ser Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 78
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX D104N/K106S

<400> 78
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asn Asn Ser Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 79
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K106N/V108S

<400> 79
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Asn Val Ser Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 80
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX D85N

<400> 80
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asn Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 81
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX T148A

<400> 81
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Ala Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 82
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K5A

<400> 82
Tyr Asn Ser Gly Ala Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 83
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX D64N

<400> 83
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asn
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 84
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX D64A

<400> 84
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Ala
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 85
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX N167D

<400> 85
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asp Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 86
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX N167Q

<400> 86
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Gln Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 87
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX S61A

<400> 87
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ala Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 88
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX S53A

<400> 88
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ala Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 89
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX T159A

<400> 89
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Ala Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 90
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX T169A

<400> 90
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Ala Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 91
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX T172A

<400> 91
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Ala Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 92
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX T179A

<400> 92
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Ala Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 93
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155H

<400> 93
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp His Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 94
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155Q

<400> 94
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Gln Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 95
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX S158A

<400> 95
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ala Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 96
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX S158D

<400> 96
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Asp Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 97
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX S158E

<400> 97
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Glu Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 98
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX N157Q

<400> 98
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Gln Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 99
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX D203N/F205T

<400> 99
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asn Ala Thr Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 100
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX D85N/D203N/F205T

<400> 100
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asn Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asn Ala Thr Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 101
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K228N

<400> 101
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 102
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX D85N/K228N

<400> 102
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asn Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 103
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX I251S

<400> 103
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ser Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 104
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX D85N/I251S

<400> 104
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asn Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ser Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 105
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX D85N/D104N/K106S/I251S

<400> 105
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asn Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asn Asn Ser Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ser Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 106
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX A262S

<400> 106
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ser Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 107
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K413N

<400> 107
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Asn Leu Thr
                405                 410                 415 


<210> 108
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX E410N

<400> 108
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 109
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX E239N

<400> 109
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Asn Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 110
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX T241N/H243S

<400> 110
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Asn Glu Ser Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 111
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K247N/N249S

<400> 111
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 112
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX L321N

<400> 112
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Asn Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 113
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX F314N/H315S

<400> 113
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Asn Ser Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 114
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K392N/K394S

<400> 114
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Asn Gly Ser Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 115
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX S319N/L321S

<400> 115
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Asn Ala
305                 310                 315                 320 
Ser Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 116
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX N260S

<400> 116
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Ser Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 117
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y284N

<400> 117
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Asn Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 118
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX G317N

<400> 118
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Asn Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 119
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R318N/A320S

<400> 119
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Asn Ser Ser
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 120
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R318A

<400> 120
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Ala Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 121
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R318E

<400> 121
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Glu Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 122
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R318Y

<400> 122
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 123
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R312Q

<400> 123
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Gln Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 124
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R312A

<400> 124
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Ala Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 125
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R312Y

<400> 125
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Tyr Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 126
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R312L

<400> 126
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Leu Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 127
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX V202M

<400> 127
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Met Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 128
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX V202Y

<400> 128
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Tyr Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 129
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX D203M

<400> 129
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Met Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 130
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX D203Y

<400> 130
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Tyr Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 131
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX A204M

<400> 131
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Met Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 132
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX A204Y

<400> 132
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Tyr Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 133
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K400A/R403A

<400> 133
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Ala
385                 390                 395                 400 
Val Ser Ala Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 134
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K400E/R403E

<400> 134
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Glu
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 135
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R403A

<400> 135
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Ala Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 136
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R403E

<400> 136
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 137
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K400A

<400> 137
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Ala
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 138
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K400E

<400> 138
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Glu
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 139
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K293E

<400> 139
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Glu Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 140
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K293A

<400> 140
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Ala Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 141
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R333A

<400> 141
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Ala Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 142
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R333E

<400> 142
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Glu Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 143
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R338A

<400> 143
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Ala Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 144
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R338E

<400> 144
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 145
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R338A/R403A

<400> 145
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Ala Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Ala Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 146
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R338E/R403E

<400> 146
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 147
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K293A/R403A

<400> 147
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Ala Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Ala Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 148
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K293E/R403E

<400> 148
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Glu Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 149
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K293A/R338A/R403A

<400> 149
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Ala Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Ala Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Ala Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 150
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K293E/R338E/R403E

<400> 150
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Glu Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 151
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R318A/R403A

<400> 151
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Ala Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Ala Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 152
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R318E/R403E

<400> 152
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Glu Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 153
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R318Y/E410N

<400> 153
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 154
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R338E/E410N

<400> 154
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 155
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R338E/R403E/E410N

<400> 155
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 156
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R318Y/R338E/R403E

<400> 156
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 157
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX D203N/F205T/K228N

<400> 157
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asn Ala Thr Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 158
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX D203N/F205T/E410N

<400> 158
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asn Ala Thr Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 159
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX D203N/F205T/R338E

<400> 159
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asn Ala Thr Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 160
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX D203N/F205T/R338A

<400> 160
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asn Ala Thr Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Ala Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 161
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX D203N/F205T/R318Y

<400> 161
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asn Ala Thr Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 162
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX D203N/F205T/R338E/R403E

<400> 162
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asn Ala Thr Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 163
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K228N/E410N

<400> 163
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 164
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K228N/R338E

<400> 164
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 165
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K228N/R338A

<400> 165
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Ala Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 166
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K228N/R318Y

<400> 166
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 167
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K228N/R338E/R403E

<400> 167
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 168
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R403E/E410N

<400> 168
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 169
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R318Y/R338E/E410N

<400> 169
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 170
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K228N/R318Y/E410N

<400> 170
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 171
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R318Y/R403E/E410N

<400> 171
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 172
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R318Y/R338E/R403E/E410N

<400> 172
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 173
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX D203N/F205T/R318Y/E410N

<400> 173
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asn Ala Thr Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 174
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX E410Q

<400> 174
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Gln Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 175
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX E410S

<400> 175
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Ser Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 176
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX E410A

<400> 176
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Ala Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 177
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX F314N/K316S

<400> 177
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Asn His Ser Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 178
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX A103N/N105S/K247N/N249S

<400> 178
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Asn Asp Ser Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 179
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX D104N/K106S/K247N/N249S

<400> 179
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asn Asn Ser Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 180
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX K228N/I251S

<400> 180
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ser Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 181
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX A103N/N105S/I251S

<400> 181
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Asn Asp Ser Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ser Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 182
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX D104N/K106S/I251S

<400> 182
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asn Asn Ser Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ser Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 183
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX K228N/K247N/N249S

<400> 183
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 184
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX D104N/K106S/K228N/K247N/N249S

<400> 184
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asn Asn Ser Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 185
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX D104N/K106S/N260S

<400> 185
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asn Asn Ser Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Ser Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 186
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX R333S

<400> 186
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Ser Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 187
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX R333L

<400> 187
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Leu Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 188
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX R318Y/R338E

<400> 188
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 189
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX K316N

<400> 189
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Asn Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 190
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX K316A

<400> 190
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Ala Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 191
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX K316E

<400> 191
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Glu Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 192
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX K316S

<400> 192
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Ser Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 193
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX K316M

<400> 193
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Met Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 194
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX E239S

<400> 194
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Ser Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 195
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX E239A

<400> 195
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Ala Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 196
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX E239R

<400> 196
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Arg Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 197
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX E239K

<400> 197
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Lys Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 198
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX H257F

<400> 198
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
Phe Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 199
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX H257Y

<400> 199
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
Tyr Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 200
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX H257E

<400> 200
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
Glu Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 201
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX H257S

<400> 201
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
Ser Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 202
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX T412A

<400> 202
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Ala Lys Leu Thr
                405                 410                 415 


<210> 203
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX T412V

<400> 203
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Val Lys Leu Thr
                405                 410                 415 


<210> 204
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX E410N/T412A

<400> 204
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Ala Lys Leu Thr
                405                 410                 415 


<210> 205
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX E410N/T412V

<400> 205
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Val Lys Leu Thr
                405                 410                 415 


<210> 206
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX E410D

<400> 206
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asp Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 207
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX N346D

<400> 207
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asp Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 208
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX N346Y

<400> 208
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Tyr Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 209
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX T343R

<400> 209
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 210
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX T343E

<400> 210
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Glu Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 211
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX T343Q

<400> 211
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Gln Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 212
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX F342I

<400> 212
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Ile Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 213
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX Y345A

<400> 213
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Ala Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 214
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX Y345T

<400> 214
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Thr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 215
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX T343R/Y345T

<400> 215
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Arg Ile Thr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 216
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX Y259F/K265T/Y345T

<400> 216
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Phe Asn Ala Ala Ile Asn Thr Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Thr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 217
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX A103N/N105S/K228N

<400> 217
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Asn Asp Ser Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 218
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX D104N/K106S/K228N

<400> 218
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asn Asn Ser Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 219
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX A103N/N105S/R318Y/R338E/R403E/E410N

<400> 219
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Asn Asp Ser Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 220
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX D104N/K106S/R318Y/R338E/R403E/E410N

<400> 220
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asn Asn Ser Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 221
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX K228N/R318Y/R338E/R403E/E410N

<400> 221
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 222
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX I251S/R318Y/R338E/R403E/E410N

<400> 222
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ser Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 223
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX
      D104N/K106S/I251S/R318Y/R338E/R403E/E410N

<400> 223
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asn Asn Ser Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ser Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 224
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX D104N/K106S/R318Y/R338E/E410N

<400> 224
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asn Asn Ser Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 225
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX I251S/R318Y/R338E/E410N

<400> 225
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ser Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 226
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX D104N/K106S/I251S/R318Y/R338E/E410N

<400> 226
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asn Asn Ser Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ser Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 227
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX A103N/N105S/Y155F

<400> 227
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Asn Asp Ser Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 228
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX D104N/K106S/Y155F

<400> 228
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asn Asn Ser Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 229
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX Y155F/K228N

<400> 229
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 230
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX Y155F/I251S

<400> 230
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ser Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 231
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX Y155F/K247N/N249S

<400> 231
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 232
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX
      A103N/N105S/K247N/N249S/R318Y/R338E/R403E/E410N

<400> 232
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Asn Asp Ser Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 233
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX
      D104N/K106S/K247N/N249S/R318Y/R338E/R403E/E410N

<400> 233
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asn Asn Ser Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 234
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX
      K228N/K247N/N249S/R318Y/R338E/R403E/E410N

<400> 234
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 235
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX
      A103N/N105S/Y155F/R318Y/R338E/R403E/E410N

<400> 235
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Asn Asp Ser Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 236
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX
      D104N/K106S/Y155F/R318Y/R338E/R403E/E410N

<400> 236
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asn Asn Ser Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 237
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX Y155F/K228N/R318Y/R338E/R403E/E410N

<400> 237
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 238
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX Y155F/I251S/R318Y/R338E/R403E/E410N

<400> 238
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ser Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 239
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX
      Y155F/K247N/N249S/R318Y/R338E/R403E/E410N

<400> 239
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 240
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX K247N/N249S/R318Y/R338E/R403E/E410N

<400> 240
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 241
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX Y155F/R318Y/R338E/R403E/E410N

<400> 241
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 242
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX K247N/N249S/R318Y/R338E/E410N

<400> 242
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 243
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX Y155F/R318Y/R338E/E410N

<400> 243
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 244
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX Y155F/K247N/N249S/R318Y/R338E/E410N

<400> 244
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 245
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX D104N/K106S/Y155F/K228N/K247N/N249S

<400> 245
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asn Asn Ser Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 246
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX D104N/K106S/Y155F/K247N/N249S

<400> 246
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asn Asn Ser Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 247
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX D104N/K106S/Y155F/K228N

<400> 247
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asn Asn Ser Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 248
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX Y155F/K228N/K247N/N249S

<400> 248
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 249
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX R318Y/R338E/R403E/E410S

<400> 249
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Ser Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 250
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX R318Y/R338E/R403E/E410N/T412V

<400> 250
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Val Lys Leu Thr
                405                 410                 415 


<210> 251
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX R318Y/R338E/R403E/E410N/T412A

<400> 251
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Ala Lys Leu Thr
                405                 410                 415 


<210> 252
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX R318Y/R338E/R403E/T412A

<400> 252
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Ala Lys Leu Thr
                405                 410                 415 


<210> 253
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX R318Y/R338E/E410S

<400> 253
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Ser Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 254
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX R318Y/R338E/T412A

<400> 254
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Ala Lys Leu Thr
                405                 410                 415 


<210> 255
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX R318Y/R338E/E410N/T412V

<400> 255
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Val Lys Leu Thr
                405                 410                 415 


<210> 256
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX D85N/K228N/R318Y/R338E/R403E/E410N

<400> 256
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asn Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 257
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX N260S/R318Y/R338E/R403E/E410N

<400> 257
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Ser Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 258
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX R318Y/R338E/N346D/R403E/E410N

<400> 258
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asp Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 259
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX Y155F/N346D

<400> 259
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asp Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 260
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX Y155F/R318Y/R338E/N346D/R403E/E410N

<400> 260
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asp Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 261
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX Y155F/N260S/N346D

<400> 261
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Ser Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asp Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 262
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX K247N/N249S/N260S

<400> 262
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Ser Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 263
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX Y155F/N260S

<400> 263
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Ser Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 264
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX
      K247N/N249S/N260S/R318Y/R338E/R403E/E410N

<400> 264
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Ser Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 265
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX
      D104N/K106S/N260S/R318Y/R338E/R403E/E410N

<400> 265
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asn Asn Ser Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Ser Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 266
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX Y155F/N260S/R318Y/R338E/R403E/E410N

<400> 266
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Ser Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 267
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX R318Y/R338E/T343R/R403E/E410N

<400> 267
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 268
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX R338E/T343R

<400> 268
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 269
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX D104N/K106S/Y155F/N260S

<400> 269
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asn Asn Ser Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Ser Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 270
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX Y155F/K247N/N249S/N260S

<400> 270
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Ser Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 271
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX D104N/K106S/K247N/N249S/N260S

<400> 271
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asn Asn Ser Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Ser Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 272
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor IX D104N/K106S/Y155F/K247N/N249S/N260S

<400> 272
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asn Asn Ser Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Ser Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 273
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-D[64]N-For

<400> 273
ggcggcagtt gcaagaacga cattaattcc tatg                             34

<210> 274
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-D[64]A-For

<400> 274
ggcggcagtt gcaaggctga cattaattcc tatg                             34

<210> 275
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-N[157]Q-For

<400> 275
cctgatgtgg actatgtaca gtctactgaa gctgaaacc                        39

<210> 276
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-N[157]D-For

<400> 276
cctgatgtgg actatgtaga ctctactgaa gctgaaacc                        39

<210> 277
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-N[167]Q-For

<400> 277
gaaaccattt tggatcagat cactcaaagc acc                              33

<210> 278
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-N[167]D-For

<400> 278
gaaaccattt tggatgacat cactcaaagc acc                              33

<210> 279
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-S[61]A-For

<400> 279
ccatgtttaa atggcggcgc ttgcaaggat gacattaatt cc                    42

<210> 280
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-S[53]A-For

<400> 280
gatggagatc agtgtgaggc taatccatgt ttaaatggc                        39

<210> 281
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-T[159]A-For

<400> 281
gtggactatg taaattctgc tgaagctgaa accattttg                        39

<210> 282
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-T[169]A-For

<400> 282
cattttggat aacatcgctc aaagcaccca atcatttaat gac                   43

<210> 283
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-T[172]A-For

<400> 283
gataacatca ctcaaagcgc tcaatcattt aatgac                           36

<210> 284
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-T[179]A-For

<400> 284
caatcattta atgacttcgc tcgggttgtt ggtggagaag                       40

<210> 285
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-Y[155]F-For

<400> 285
gtttttcctg atgtggactt cgtaaattct actgaagctg                       40

<210> 286
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-Y[155]H-For

<400> 286
gtttttcctg atgtggacca cgtaaattct actgaagctg                       40

<210> 287
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-Y[155]Q-For

<400> 287
gtttttcctg atgtggacca ggtaaattct actgaagctg                       40

<210> 288
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-S[158]A-For

<400> 288
gtggactatg taaatgctac tgaagctgaa acc                              33

<210> 289
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-S[158]D-For

<400> 289
gtggactatg taaatgacac tgaagctgaa acc                              33

<210> 290
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-S[158]E-For

<400> 290
gtggactatg taaatgagac tgaagctgaa acc                              33

<210> 291
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-R165S-For

<400> 291
gttccacttg ttgacagcgc cacatgtctt cgatct                           36

<210> 292
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-R170L-For

<400> 292
cgagccacat gtcttctgtc tacaaagttc acc                              33

<210> 293
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-K148N-For

<400> 293
ggaagagtct tccacaacgg gagatcagct ttag                             34

<210> 294
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-K148A-For

<400> 294
ggaagagtct tccacgctgg gagatcagct ttag                             34

<210> 295
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-K148E-For

<400> 295
ggaagagtct tccacgaggg gagatcagct ttag                             34

<210> 296
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-K148S-For

<400> 296
ggaagagtct tccacagcgg gagatcagct ttag                             34

<210> 297
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-K148M-For

<400> 297
ggaagagtct tccacatggg gagatcagct ttag                             34

<210> 298
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-E74S-For

<400> 298
ggtgaacata atattagcga gacagaacat acag                             34

<210> 299
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-E74A-For

<400> 299
ggtgaacata atattgctga gacagaacat acag                             34

<210> 300
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-E74R-For

<400> 300
ggtgaacata atattaggga gacagaacat acag                             34

<210> 301
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-E74K-For

<400> 301
ggtgaacata atattaagga gacagaacat acag                             34

<210> 302
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-H92F-For-Corr

<400> 302
cgaattattc ctcacttcaa ctacaatgca gc                               32

<210> 303
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-H92Y-For-Corr

<400> 303
cgaattattc ctcactacaa ctacaatgca gc                               32

<210> 304
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-H92E-For-Corr

<400> 304
cgaattattc ctcacgaaaa ctacaatgca gc                               32

<210> 305
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-H92S-For-Corr

<400> 305
cgaattattc ctcacagcaa ctacaatgca gc                               32

<210> 306
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-T242A-For

<400> 306
ctggattaag gaaaaagcta agctcactta agtg                             34

<210> 307
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-T242V-For

<400> 307
ctggattaag gaaaaagtga agctcactta agtg                             34

<210> 308
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-E240N/T242A-For

<400> 308
gtcaactgga ttaagaacaa agctaagctc acttaagtg                        39

<210> 309
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-E240N/T242V-For

<400> 309
gtcaactgga ttaagaacaa agtgaagctc acttaagtg                        39

<210> 310
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-E240Q-For

<400> 310
gtcaactgga ttaagcagaa aacaaagctc acttaag                          37

<210> 311
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-E240S-For

<400> 311
gtcaactgga ttaagagcaa aacaaagctc acttaag                          37

<210> 312
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-E240A-For

<400> 312
gtcaactgga ttaaggctaa aacaaagctc acttaag                          37

<210> 313
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-E240D-For

<400> 313
gtcaactgga ttaaggacaa aacaaagctc acttaag                          37

<210> 314
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-N178D-For

<400> 314
caaagttcac catctatgac aacatgttct gtgctggc                         38

<210> 315
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-N178Y-For

<400> 315
caaagttcac catctattac aacatgttct gtgctggc                         38

<210> 316
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-Y177A-For

<400> 316
ctacaaagtt caccatcgct aacaacatgt tctgtgc                          37

<210> 317
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-Y177T-For

<400> 317
ctacaaagtt caccatcacc aacaacatgt tctgtgc                          37

<210> 318
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-T175R-For

<400> 318
cttcgatcta caaagttcag gatctataac aacatgttc                        39

<210> 319
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-T175E-For

<400> 319
cttcgatcta caaagttcga aatctataac aacatgttc                        39

<210> 320
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-T175Q-For

<400> 320
cttcgatcta caaagttcca gatctataac aacatgttc                        39

<210> 321
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-F174I/Y177T-For

<400> 321
gtcttcgatc tacaaagatc accatctata acaacatg                         38

<210> 322
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-T175R/Y177T-For

<400> 322
cgatctacaa agttcaggat caccaacaac atgttctgtg                       40

<210> 323
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-Y94F/K98T-For

<400> 323
gaattattcc tcaccacaac ttcaatgcag ctattaatac ctacaaccat gacattg    57

<210> 324
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> F9-F145N/K148S-For

<400> 324
ggctggggaa gagtcaacca cagcgggaga tcagctttag                       40

<210> 325
<211> 461
<212> PRT
<213> Homo sapiens

<220> 
<223> BeneFIX precursor

<400> 325
Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr
 1               5                  10                  15      
Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu
            20                  25                  30          
Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn
        35                  40                  45              
Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys
    50                  55                  60                  
Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn
65                  70                  75                  80  
Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln
                85                  90                  95      
Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile
            100                 105                 110         
Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys
        115                 120                 125             
Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe
    130                 135                 140                 
Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly
145                 150                 155                 160 
Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe
                165                 170                 175     
Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala
            180                 185                 190         
Glu Ala Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu
        195                 200                 205             
Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe
    210                 215                 220                 
Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp
225                 230                 235                 240 
Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile
                245                 250                 255     
Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly
            260                 265                 270         
Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu
        275                 280                 285             
His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn
    290                 295                 300                 
Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu
305                 310                 315                 320 
Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile
                325                 330                 335     
Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr
            340                 345                 350         
Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val
        355                 360                 365             
Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg
    370                 375                 380                 
Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His
385                 390                 395                 400 
Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val
                405                 410                 415     
Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly
            420                 425                 430         
Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser
        435                 440                 445             
Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
    450                 455                 460     


<210> 326
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX D104N/K106S/Y155F/K247N/
      N249S/R318Y/R338E/R403E/E410N

<400> 326
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asn Asn Ser Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 327
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX D104N/K106S/K228N/K247N/
      N249S/R318Y/R338E/R403E/E410N

<400> 327
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asn Asn Ser Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 328
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/K228N/K247N/N249S/
      R318Y/R338E/R403E/E410N

<400> 328
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 329
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/K247N/N249S/N260S/
      R318Y/R338E/R403E/E410N
      

<400> 329
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Ser Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 330
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/R318Y/R338E/T343R/R403E/E410N

<400> 330
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 331
<211> 415
<212> PRT
<213> Homo sapeins

<220> 
<223> Factor IX
      D104N/K106S/R318Y/R338E/T343R/R403E/E410N

<400> 331
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asn Asn Ser Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 332
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX T343R/N346Y

<400> 332
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Arg Ile Tyr Tyr Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 333
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R318Y/R338E/N346Y/R403E/E410N

<400> 333
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Tyr Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 334
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R318Y/R338E/T343R/N346Y/R403E/E410N

<400> 334
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Tyr Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 335
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX T343R/N346D

<400> 335
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Arg Ile Tyr Asp Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 336
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R318Y/R338E/T343R/N346D/R403E/E410N

<400> 336
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asp Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 337
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R318Y/R338E/Y345A/R403E/E410N

<400> 337
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Ala Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 338
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R318Y/R338E/Y345A/N346D/R403E/E410N

<400> 338
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Ala Asp Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 339
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/K247N/N249S/R318Y/R338E/R403E

<400> 339
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 340
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K247N/N249S/R318Y/R338E/R403E

<400> 340
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 341
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/K247N/N249S/R318Y/R403E/E410N

<400> 341
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 342
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K247N/N249S/R318Y/R403E/E410N

<400> 342
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 343
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/K247N/N249S/R338E/R403E/E410N

<400> 343
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 344
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K247N/N249S/R338E/R403E/E410N

<400> 344
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 345
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R318Y/R338E/T343R/R403E

<400> 345
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 346
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/R318Y/R338E/T343R/R403E

<400> 346
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 347
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R318Y/R338E/T343R/E410N

<400> 347
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 348
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/R318Y/R338E/T343R/E410N

<400> 348
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 349
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R318Y/T343R/R403E/E410N

<400> 349
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 350
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/R318Y/T343R/R403E/E410N

<400> 350
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 351
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R338E/T343R/R403E/E410N

<400> 351
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 352
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/R338E/T343R/R403E/E410N

<400> 352
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 353
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/K247N/N249S/R318Y/R338E/
      T343R/R403E/E410N

<400> 353
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 354
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX
      K247N/N249S/R318Y/R338E/T343R/R403E/E410N

<400> 354
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 355
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K228N/I251S/R318Y/R338E/R403E/E410N

<400> 355
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ser Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 356
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX
      Y155F/K228N/I251S/R318Y/R338E/R403E/E410N

<400> 356
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ser Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 357
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX N260S/R318Y/R338E/T343R/R403E/E410N

<400> 357
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Ser Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 358
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/N260S/R318Y/R338E/T343R/
      R403E/E410N

<400> 358
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Ser Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 359
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K228N/K247N/N249S/R318Y/R338E/
      T343R/R403E/E410N

<400> 359
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 360
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/K228N/K247N/N249S/R318Y/
      R338E/T343R/R403E/E410N

<400> 360
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 361
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/R338E/T343R/R403E

<400> 361
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 362
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R338E/T343R/R403E

<400> 362
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 363
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/R338E/T343R/R403E/E410S

<400> 363
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Ser Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 364
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/N260S/R338E/T343R/R403E

<400> 364
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Ser Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 365
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/I251S/R338E/T343R/R403E

<400> 365
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ser Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 366
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R318Y/R338E/T343R/R403E/E410S

<400> 366
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Ser Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 367
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/K247N/N249S/T343R/R403E

<400> 367
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 368
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX
      Y155F/K247N/N249S/R318Y/R338E/T343R/R403E
      

<400> 368
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 369
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K247N/N249S/R318Y/R338E/T343R/R403E

<400> 369
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 370
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/K247N/N249S/R338E/T343R/
      R403E/E410N

<400> 370
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 371
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K247N/N249S/R338E/T343R/R403E/E410N

<400> 371
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 372
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/K247N/N249S/R318Y/R338E

<400> 372
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 373
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/K247N/N249S/R318Y/T343R

<400> 373
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 374
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/K247N/N249S/R318Y/R403E

<400> 374
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 375
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/K247N/N249S/R318Y/E410N

<400> 375
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 376
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/K247N/N249S/R338E/R403E

<400> 376
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 377
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/K247N/N249S/R338E/T343R

<400> 377
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 378
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX
      Y155F/K247N/N249S/R318Y/R338E/T343R/E410N

<400> 378
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 379
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K247N/N249S/R318Y/R338E/T343R/ E410N

<400> 379
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 380
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX
      Y155F/K247N/N249S/R318Y/T343R/R403E/E410N

<400> 380
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 381
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K247N/N249S/R318Y/T343R/R403E/E410N

<400> 381
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 382
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/K247N/N249S/R338E/E410N

<400> 382
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 383
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/K247N/N249S/R318Y/T343R/ R403E

<400> 383
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 384
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K247N/N249S/R318Y/T343R/R403E

<400> 384
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 385
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/K247N/N249S/R318Y/T343R/E410N

<400> 385
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 386
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K247N/N249S/R318Y/T343R/E410N

<400> 386
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 387
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/K247N/N249S/R338E/T343R/ R403E

<400> 387
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 388
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K247N/N249S/R338E/T343R/R403E

<400> 388
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 389
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX  Y155F/K247N/N249S/R338E/T343R/ E410N

<400> 389
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 390
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX  K247N/N249S/R338E/T343R/E410N

<400> 390
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 391
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX  Y155F/K247N/N249S/T343R/R403E/ E410N

<400> 391
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 392
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX  K247N/N249S/T343R/R403E/E410N

<400> 392
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 393
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX  Y155F/R318Y/R338E/T343R

<400> 393
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 394
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX  R318Y/R338E/T343R

<400> 394
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 395
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX  Y155F/R318Y/T343R/R403E

<400> 395
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 396
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX  Y155F/T343R/R403E/E410N

<400> 396
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 397
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX  Y155F/K247N/N249S/R318Y/R338E/ T343R

<400> 397
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 398
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K247N/N249S/R318Y/R338E/T343R

<400> 398
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 399
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/K247N/N249S/T343R/E410N

<400> 399
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 400
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/K247N/N249S/R403E/E410N

<400> 400
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 401
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/R338E/T343R/E410N

<400> 401
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 402
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R338E/T343R/E410N

<400> 402
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 403
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/R318Y/T343R/E410N

<400> 403
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 404
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R318Y/T343R/E410N

<400> 404
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 405
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K228N/R318Y/R338E/T343R/R403E/ E410N

<400> 405
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 406
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K228N/K247N/N249S/R318Y/R338E/
      T343R/R403E

<400> 406
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 407
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX
      K228N/K247N/N249S/R318Y/R338E/T343R/E410N

<400> 407
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 408
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX K228N/K247N/N249S/R318Y/T343R/
      R403E/E410N

<400> 408
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Asn Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Asn Arg Ser Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 409
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/R338E/R403E/E410N

<400> 409
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Glu Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 410
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/R318Y/R338E/R403E

<400> 410
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 411
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155F/R318Y/R403E/E410N

<400> 411
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Phe Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Glu Tyr Val Asn Trp Ile Lys Asn Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 412
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y1N

<400> 412
Asn Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 413
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R318F

<400> 413
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Phe Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 414
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R318W

<400> 414
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Trp Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 415
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX Y155L

<400> 415
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Leu Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 416
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX T343D

<400> 416
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Asp Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 417
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> Factor IX R403D

<400> 417
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Asp Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 418
<211> 737
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide KP1 Capsid

<400> 418
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser
 1               5                  10                  15      
Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro
            20                  25                  30          
Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro
    50                  55                  60                  
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp
65                  70                  75                  80  
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro
        115                 120                 125             
Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg
    130                 135                 140                 
Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly
145                 150                 155                 160 
Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr
                165                 170                 175     
Gly Asp Thr Asp Ser Ala Ala Asp Pro Gln Pro Leu Gly Glu Pro Pro
            180                 185                 190         
Ala Ala Pro Ser Gly Leu Gly Thr Gly Thr Met Ala Ala Gly Gly Gly
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu
                245                 250                 255     
Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His
            260                 265                 270         
Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe
        275                 280                 285             
His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn
    290                 295                 300                 
Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln
305                 310                 315                 320 
Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn
                325                 330                 335     
Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro
            340                 345                 350         
Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala
        355                 360                 365             
Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly
    370                 375                 380                 
Ser Gln Ala Met Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro
385                 390                 395                 400 
Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr Phe
                405                 410                 415     
Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp
            420                 425                 430         
Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg
        435                 440                 445             
Thr Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe
    450                 455                 460                 
Ser Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu
465                 470                 475                 480 
Pro Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp
                485                 490                 495     
Asn Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu
            500                 505                 510         
Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His
        515                 520                 525             
Lys Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe
    530                 535                 540                 
Gly Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met
545                 550                 555                 560 
Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu
                565                 570                 575     
Gln Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro
            580                 585                 590         
Thr Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp
        595                 600                 605             
Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro
    610                 615                 620                 
His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly
625                 630                 635                 640 
Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro
                645                 650                 655     
Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile
            660                 665                 670         
Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu
        675                 680                 685             
Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser
    690                 695                 700                 
Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly
705                 710                 715                 720 
Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn
                725                 730                 735     
Leu
    


<210> 419
<211> 737
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide KP2 Capsid

<400> 419
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser
 1               5                  10                  15      
Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro
            20                  25                  30          
Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro
    50                  55                  60                  
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp
65                  70                  75                  80  
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro
        115                 120                 125             
Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg
    130                 135                 140                 
Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Ile Gly
145                 150                 155                 160 
Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr
                165                 170                 175     
Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro
            180                 185                 190         
Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu
                245                 250                 255     
Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His
            260                 265                 270         
Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe
        275                 280                 285             
His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn
    290                 295                 300                 
Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln
305                 310                 315                 320 
Val Lys Glu Val Thr Gln Asn Glu Gly Thr Thr Thr Ile Ala Asn Asn
                325                 330                 335     
Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro
            340                 345                 350         
Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala
        355                 360                 365             
Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly
    370                 375                 380                 
Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro
385                 390                 395                 400 
Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe
                405                 410                 415     
Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp
            420                 425                 430         
Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg
        435                 440                 445             
Thr Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe
    450                 455                 460                 
Ser Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu
465                 470                 475                 480 
Pro Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp
                485                 490                 495     
Asn Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu
            500                 505                 510         
Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His
        515                 520                 525             
Lys Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe
    530                 535                 540                 
Gly Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met
545                 550                 555                 560 
Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu
                565                 570                 575     
Gln Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro
            580                 585                 590         
Thr Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp
        595                 600                 605             
Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro
    610                 615                 620                 
His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly
625                 630                 635                 640 
Leu Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro
                645                 650                 655     
Ala Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile
            660                 665                 670         
Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu
        675                 680                 685             
Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser
    690                 695                 700                 
Asn Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly
705                 710                 715                 720 
Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro
                725                 730                 735     
Leu
    


<210> 420
<211> 738
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide KP3 Capsid

<400> 420
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser
 1               5                  10                  15      
Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro
            20                  25                  30          
Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro
    50                  55                  60                  
Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp
65                  70                  75                  80  
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro
        115                 120                 125             
Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg
    130                 135                 140                 
Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile
145                 150                 155                 160 
Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln
                165                 170                 175     
Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro
            180                 185                 190         
Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly
        195                 200                 205             
Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn
    210                 215                 220                 
Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val
225                 230                 235                 240 
Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His
                245                 250                 255     
Leu Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn
            260                 265                 270         
His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg
        275                 280                 285             
Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn
    290                 295                 300                 
Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile
305                 310                 315                 320 
Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn
                325                 330                 335     
Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu
            340                 345                 350         
Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro
        355                 360                 365             
Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn
    370                 375                 380                 
Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe
385                 390                 395                 400 
Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr
                405                 410                 415     
Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu
            420                 425                 430         
Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn
        435                 440                 445             
Arg Thr Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu
    450                 455                 460                 
Phe Ser Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp
465                 470                 475                 480 
Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn
                485                 490                 495     
Asp Asn Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His
            500                 505                 510         
Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser
        515                 520                 525             
His Lys Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile
    530                 535                 540                 
Phe Gly Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val
545                 550                 555                 560 
Met Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr
                565                 570                 575     
Glu Gln Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala
            580                 585                 590         
Pro Thr Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val
        595                 600                 605             
Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile
    610                 615                 620                 
Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe
625                 630                 635                 640 
Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val
                645                 650                 655     
Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe
            660                 665                 670         
Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu
        675                 680                 685             
Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr
    690                 695                 700                 
Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu
705                 710                 715                 720 
Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg
                725                 730                 735     
Asn Leu
        


<210> 421
<211> 2214
<212> DNA
<213> Artificial Sequence

<220> 
<223> KP1 Capsid

<400> 421
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga 60
cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac 120
gacagcaggg gtcttgtgct tccgggttac aaatacctcg gacccggcaa cggactcgac 180
aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac 240
cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt 300
caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag 360
gccaagaagc gggttctcga acctctcggt ctggttgagg aacctgttaa gacggctccg 420
ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga 480
aaggcgggcc agcagcctgc gaggaagcga ctcaactttg gtcagactgg agacaccgac 540
tccgccgctg acccccagcc tctcggagaa ccaccagcag ccccctctgg tctgggaact 600
ggtacaatgg ctgcaggcgg tggcgctcca atggcagaca ataacgaagg cgccgacgga 660
gtgggtaatg cctcgggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc 720
accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc 780
tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg 840
gggtactttg acttcaaccg cttccactgc cacttctcac cacgtgactg gcaaagactc 900
atcaacaaca actggggatt ccggcccaag agactcaact tcaagctctt caacatccag 960
gtcaaggagg tcacgcagaa tgaaggcacc aagaccatcg ccaataacct taccagcacg 1020
gttcaggtgt ttactgactc ggagtaccag ctgccgtacg ttctcggctc tgcccaccag 1080
ggctgcctgc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg 1140
ctcaacaatg gcagccaggc gatgggtcgc tcgtccttct actgcctgga gtactttccg 1200
tcgcagatgc tgagaaccgg caacaacttc cagtttactt acaccttcga ggacgtgcct 1260
ttccacagca gctacgctca cagccagagt ttggatcgct tgatgaatcc tcttattgat 1320
cagtatctgt actacctgaa cagaacgcaa ggaacaacct ctggaacaac caaccaatca 1380
cggctgcttt ttagccaggc tgggcctcag tctatgtctt tgcaggccag aaattggcta 1440
cctgggccct gctaccggca acagagactt tcaaagactg ctaacgacaa caacaacagt 1500
aactttcctt ggacagcggc cagcaaatat catctcaatg gccgcgactc gctggtgaat 1560
ccaggaccag ctatggccag tcacaaggac gatgaagaaa aatttttccc tatgcacggc 1620
aatctaatat ttggcaaaga agggacaacg gcaagtaacg cagaattaga taatgtaatg 1680
attacggatg aagaagagat tcgtaccacc aatcctgtgg caacagagca gtatggaact 1740
gtggcaaata acttgcagag ctcaaataca gctcccacga ctagaactgt caatgatcag 1800
ggggccttac ctggcatggt gtggcaagat cgtgacgtgt accttcaagg acctatctgg 1860
gcaaagattc ctcacacgga tggacacttt catccttctc ctctgatggg cggctttggc 1920
ctgaaacatc ctccgcctca gatcctgatc aagaacacgc ctgtacctgc ggatcctcca 1980
acggccttca acaaggacaa gctgaactct ttcatcaccc agtattctac tggccaagtc 2040
agcgtggaga tcgagtggga gctgcagaag gaaaacagca agcgctggaa ccccgagatc 2100
cagtacacct ccaactacta caaatctaca agtgtggact ttgctgttaa tacagaaggc 2160
gtgtactctg aaccccgccc cattggcacc cgttacctca cccgtaatct gtaa       2214

<210> 422
<211> 2214
<212> DNA
<213> Artificial Sequence

<220> 
<223> KP2 Capsid

<400> 422
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc 60
gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac 120
gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac 180
aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac 240
cagcagctca aagcgggtga caatccgtac cttcggtata accacgccga cgccgagttt 300
caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag 360
gccaagaagc gggttctcga acctctcggt ctggttgagg aaggtgctaa gacggctcct 420
ggaaagaaac gtccggtaga gcactctcct gtggagccag actcctcctc gggcatcggc 480
aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgacgcagac 540
tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact 600
aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga 660
gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc 720
accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc 780
tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg 840
gggtactttg acttcaaccg cttccactgc cacttctccc cgcgagactg gcagcggctc 900
atcaacaaca actgggggtt ccggcccaag cgactcaact tcaagctctt caacatccag 960
gtcaaggagg tcacgcagaa tgaaggcacg acgactattg ccaataacct taccagcacg 1020
gttcaagtgt ttacggactc ggagtatcag ctcccgtacg tgctcggctc tgcccaccag 1080
ggctgcctgc ctccgttccc ggcggacgtg ttcatgattc cccagtacgg ctacctaaca 1140
ctcaacaacg gtagtcaggc cgtgggacgc tcctccttct actgcctgga atactttcct 1200
tctcagatgc tgcgtaccgg aaacaacttt accttcagct acacttttga ggacgttcct 1260
ttccacagca gctacgctca cagccagagt ttggatcgct tgatgaatcc tcttattgat 1320
cagtatctgt actacctgaa cagaacgcaa ggaacaacct ctggaacaac caaccaatca 1380
cggctgcttt ttagccaggc tgggcctcag tctatgtctt tgcaggccag aaattggcta 1440
cctgggccct gctaccggca acagagactt tcaaagactg ctaacgacaa caacaacagt 1500
aactttcctt ggacagcggc cagcaaatat catctcaatg gccgcgactc gctggtgaat 1560
ccaggaccag ctatggccag tcacaaggac gatgaagaaa aatttttccc tatgcacggc 1620
aatctaatat ttggcaaaga agggacaacg gcaagtaacg cagaattaga taatgtaatg 1680
attacggatg aagaagagat tcgtaccacc aatcctgtgg caacagagca gtatggaact 1740
gtggcaaata acttgcagag ctcaaataca gctcccacga ctagaactgt caatgatcag 1800
ggggccttac ctggcatggt gtggcaagat cgtgacgtgt accttcaagg acctatctgg 1860
gcaaagattc ctcacacgga tggacacttt catccttctc ctctgatggg aggctttgga 1920
ctgaaacatc cgcctcctca aatcatgatc aaaaatactc cggtaccggc aaatcctccg 1980
acgactttca gcccggccaa gtttgcttca tttatcactc agtactccac tggacaggtc 2040
agcgtggaaa ttgagtggga gctacagaaa gaaaacagca aacgttggaa tccagagatt 2100
cagtacactt ccaactacaa caagtctgtt aatgtggact ttactgtaga cactaatggt 2160
gtttatagtg agcctcgccc cattggcacc cgttacctca cccgtcccct gtaa       2214

<210> 423
<211> 2217
<212> DNA
<213> Artificial Sequence

<220> 
<223> KP3 Capsid

<400> 423
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga 60
cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac 120
gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac 180
aaaggagagc cggtcaacga ggcggatgca gcggccctcg agcacgacaa ggcctacgac 240
cagcagctca aagcgggtga caatccgtac cttcggtata accacgccga cgccgagttt 300
caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag 360
gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct 420
ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc 480
ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca 540
gagtcagttc cagaccctca acctctcgga gaacctccag cagcgccctc tggtgtggga 600
cctaatacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggcgccgac 660
ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc 720
atcaccacca gcacccgcac ctgggccttg cccacctaca ataaccacct ctacaagcaa 780
atctccagtg cttcaacggg ggccagcaac gacaaccact acttcggcta cagcacccct 840
tgggggtatt ttgacttcaa cagattccac tgccactttt caccacgtga ctggcaaaga 900
ctcatcaaca acaactgggg attccgaccc aagagactca acttcaagct ctttaacatt 960
caagtcaaag aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc 1020
accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcccac 1080
cagggctgcc tgcctccgtt cccggcggac gtgttcatga ttccccagta cggctaccta 1140
acactcaaca acggtagtca ggccgtggga cgctcctcct tttactgcct ggagtacttc 1200
ccttcgcaga tgctaaggac tggaaataac ttccaattca gctatacctt cgaggatgta 1260
ccttttcaca gcagctacgc tcacagccag agtttggatc gcttgatgaa tcctcttatt 1320
gatcagtatc tgtactacct gaacagaacg caaggaacaa cctctggaac aaccaaccaa 1380
tcacggctgc tttttagcca ggctgggcct cagtctatgt ctttgcaggc cagaaattgg 1440
ctacctgggc cctgctaccg gcaacagaga ctttcaaaga ctgctaacga caacaacaac 1500
agtaactttc cttggacagc ggccagcaaa tatcatctca atggccgcga ctcgctggtg 1560
aatccaggac cagctatggc cagtcacaag gacgatgaag aaaaattttt ccctatgcac 1620
ggcaatctaa tatttggcaa agaagggaca acggcaagta acgcagaatt agataatgta 1680
atgattacgg atgaagaaga gattcgtacc accaatcctg tggcaacaga gcagtatgga 1740
actgtggcaa ataacttgca gagctcaaat acagctccca cgactagaac tgtcaatgat 1800
cagggggcct tacctggcat ggtgtggcaa gatagagacg tgtacctgca gggtcctatc 1860
tgggccaaga ttcctcacac ggacggaaac tttcatccct cgccgctgat gggaggcttt 1920
ggactgaaac acccgcctcc tcagatcctg atcaagaaca cgcctgtacc tgcggatcct 1980
ccgaccacct tcaaccagtc aaagctgaac tctttcatca cgcaatacag caccggacag 2040
gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca gcaagcgctg gaaccccgag 2100
atccagtaca cctccaacta ctacaaatct acaagtgtgg actttgctgt taatacagaa 2160
ggcgtgtact ctgaaccccg ccccattggc acccgttacc tcacccgtaa tctgtaa    2217

<210> 424
<211> 2214
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV-DJ Capsid

<400> 424
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga 60
cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac 120
gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac 180
aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac 240
cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgccgagttc 300
caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag 360
gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct 420
ggaaagaaga ggcctgtaga gcactctcct gtggagccag actcctcctc gggaaccgga 480
aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac 540
tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct 600
cttacaatgg ctgcaggcgg tggcgcacca atggcagaca ataacgaggg cgccgacgga 660
gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc 720
accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc 780
tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc 840
tgggggtatt ttgactttaa cagattccac tgccactttt caccacgtga ctggcagcga 900
ctcatcaaca acaactgggg attccggccc aagagactca gcttcaagct cttcaacatc 960
caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc 1020
accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcccac 1080
cagggctgcc tgcctccgtt cccggcggac gtgttcatga ttccccagta cggctaccta 1140
acactcaaca acggtagtca ggccgtggga cgctcctcct tctactgcct ggaatacttt 1200
ccttcgcaga tgctgagaac cggcaacaac ttccagttta cttacacctt cgaggacgtg 1260
cctttccaca gcagctacgc ccacagccag agcttggacc ggctgatgaa tcctctgatt 1320
gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacgac aaatacgcag 1380
actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg 1440
ccaggaccct gttaccgcca gcagcgagta tcaaagacat ctgcggataa caacaacagt 1500
gaatactcgt ggactggagc taccaagtac cacctcaatg gcagagactc tctggtgaat 1560
ccgggcccgg ccatggcaag ccacaaggac gatgaagaaa agttttttcc tcagagcggg 1620
gttctcatct ttgggaagca aggctcagag aaaacaaatg tggacattga aaaggtcatg 1680
attacagacg aagaggaaat caggacaacc aatcccgtgg ctacggagca gtatggttct 1740
gtatctacca acctccagag aggcaacaga caagcagcta ccgcagatgt caacacacaa 1800
ggcgttcttc caggcatggt ctggcaggac agagatgtgt accttcaggg gcccatctgg 1860
gcaaagattc cacacacgga cggacatttt cacccctctc ccctcatggg tggattcgga 1920
cttaaacacc ctccgcctca gatcctgatc aagaacacgc ctgtacctgc ggatcctccg 1980
accaccttca accagtcaaa gctgaactct ttcatcaccc agtattctac tggccaagtc 2040
agcgtggaga tcgagtggga gctgcagaag gaaaacagca agcgctggaa ccccgagatc 2100
cagtacacct ccaactacta caaatctaca agtgtggact ttgctgttaa tacagaaggc 2160
gtgtactctg aaccccgccc cattggcacc cgttacctca cccgtaatct gtaa       2214

<210> 425
<211> 737
<212> PRT
<213> Artificial Sequence

<220> 
<223> AAV-DJ Capsid

<400> 425
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser
 1               5                  10                  15      
Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro
            20                  25                  30          
Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro
    50                  55                  60                  
Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp
65                  70                  75                  80  
Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro
        115                 120                 125             
Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg
    130                 135                 140                 
Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly
145                 150                 155                 160 
Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr
                165                 170                 175     
Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro
            180                 185                 190         
Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ala Gly Gly Gly
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu
                245                 250                 255     
Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn
            260                 265                 270         
Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg
        275                 280                 285             
Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn
    290                 295                 300                 
Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile
305                 310                 315                 320 
Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn
                325                 330                 335     
Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu
            340                 345                 350         
Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro
        355                 360                 365             
Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn
    370                 375                 380                 
Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe
385                 390                 395                 400 
Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr
                405                 410                 415     
Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu
            420                 425                 430         
Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser
        435                 440                 445             
Arg Thr Gln Thr Thr Gly Gly Thr Thr Asn Thr Gln Thr Leu Gly Phe
    450                 455                 460                 
Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu
465                 470                 475                 480 
Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp
                485                 490                 495     
Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu
            500                 505                 510         
Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His
        515                 520                 525             
Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe
    530                 535                 540                 
Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met
545                 550                 555                 560 
Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu
                565                 570                 575     
Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala
            580                 585                 590         
Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp
        595                 600                 605             
Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro
    610                 615                 620                 
His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly
625                 630                 635                 640 
Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro
                645                 650                 655     
Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile
            660                 665                 670         
Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu
        675                 680                 685             
Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser
    690                 695                 700                 
Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly
705                 710                 715                 720 
Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn
                725                 730                 735     
Leu
    


<210> 426
<211> 2214
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV-DJ-8 Capsid

<400> 426
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga 60
cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac 120
gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac 180
aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac 240
cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgccgagttc 300
caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag 360
gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct 420
ggaaagaaga ggcctgtaga gcactctcct gtggagccag actcctcctc gggaaccgga 480
aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac 540
tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct 600
cttacaatgg ctgcaggcgg tggcgcacca atggcagaca ataacgaggg cgccgacgga 660
gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc 720
accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc 780
tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc 840
tgggggtatt ttgactttaa cagattccac tgccactttt caccacgtga ctggcagcga 900
ctcatcaaca acaactgggg attccggccc aagagactca gcttcaagct cttcaacatc 960
caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc 1020
accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcccac 1080
cagggctgcc tgcctccgtt cccggcggac gtgttcatga ttccccagta cggctaccta 1140
acactcaaca acggtagtca ggccgtggga cgctcctcct tctactgcct ggaatacttt 1200
ccttcgcaga tgctgagaac cggcaacaac ttccagttta cttacacctt cgaggacgtg 1260
cctttccaca gcagctacgc ccacagccag agcttggacc ggctgatgaa tcctctgatt 1320
gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacgac aaatacgcag 1380
actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg 1440
ccaggaccct gttaccgcca gcagcgagta tcaaagacat ctgcggataa caacaacagt 1500
gaatactcgt ggactggagc taccaagtac cacctcaatg gcagagactc tctggtgaat 1560
ccgggcccgg ccatggcaag ccacaaggac gatgaagaaa agttttttcc tcagagcggg 1620
gttctcatct ttgggaagca aggctcagag aaaacaaatg tggacattga aaaggtcatg 1680
attacagacg aagaggaaat caggacaacc aatcccgtgg ctacggagca gtatggttct 1740
gtatctacca acctccagca aggcaacaca caagcagcta ccgcagatgt caacacacaa 1800
ggcgttcttc caggcatggt ctggcaggac agagatgtgt accttcaggg gcccatctgg 1860
gcaaagattc cacacacgga cggacatttt cacccctctc ccctcatggg tggattcgga 1920
cttaaacacc ctccgcctca gatcctgatc aagaacacgc ctgtacctgc ggatcctccg 1980
accaccttca accagtcaaa gctgaactct ttcatcaccc agtattctac tggccaagtc 2040
agcgtggaga tcgagtggga gctgcagaag gaaaacagca agcgctggaa ccccgagatc 2100
cagtacacct ccaactacta caaatctaca agtgtggact ttgctgttaa tacagaaggc 2160
gtgtactctg aaccccgccc cattggcacc cgttacctca cccgtaatct gtaa       2214

<210> 427
<211> 737
<212> PRT
<213> Artificial Sequence

<220> 
<223> AAV-DJ-8 Capsid

<400> 427
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser
 1               5                  10                  15      
Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro
            20                  25                  30          
Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro
    50                  55                  60                  
Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp
65                  70                  75                  80  
Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro
        115                 120                 125             
Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg
    130                 135                 140                 
Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly
145                 150                 155                 160 
Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr
                165                 170                 175     
Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro
            180                 185                 190         
Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ala Gly Gly Gly
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu
                245                 250                 255     
Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn
            260                 265                 270         
Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg
        275                 280                 285             
Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn
    290                 295                 300                 
Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile
305                 310                 315                 320 
Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn
                325                 330                 335     
Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu
            340                 345                 350         
Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro
        355                 360                 365             
Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn
    370                 375                 380                 
Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe
385                 390                 395                 400 
Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr
                405                 410                 415     
Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu
            420                 425                 430         
Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser
        435                 440                 445             
Arg Thr Gln Thr Thr Gly Gly Thr Thr Asn Thr Gln Thr Leu Gly Phe
    450                 455                 460                 
Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu
465                 470                 475                 480 
Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp
                485                 490                 495     
Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu
            500                 505                 510         
Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His
        515                 520                 525             
Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe
    530                 535                 540                 
Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met
545                 550                 555                 560 
Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu
                565                 570                 575     
Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Gln Gly Asn Thr Gln Ala
            580                 585                 590         
Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp
        595                 600                 605             
Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro
    610                 615                 620                 
His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly
625                 630                 635                 640 
Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro
                645                 650                 655     
Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile
            660                 665                 670         
Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu
        675                 680                 685             
Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser
    690                 695                 700                 
Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly
705                 710                 715                 720 
Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn
                725                 730                 735     
Leu
    


<210> 428
<211> 2211
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV-LK03 Capsid

<400> 428
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcga 60
gagtggtggg cgctgcaacc tggagcccct aaacccaagg caaatcaaca acatcaggac 120
aacgctcggg gtcttgtgct tccgggttac aaatacctcg gacccggcaa cggactcgac 180
aagggggaac ccgtcaacgc agcggacgcg gcagccctcg agcacgacaa ggcctacgac 240
cagcagctca aggccggtga caacccctac ctcaagtaca accacgccga cgccgagttc 300
caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag 360
gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct 420
ggaaagaaga ggcctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc 480
aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg cgactcagag 540
tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct 600
aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatgga 660
gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc 720
accaccagca ccagaacctg ggccctgccc acttacaaca accatctcta caagcaaatc 780
tccagccaat caggagcttc aaacgacaac cactactttg gctacagcac cccttggggg 840
tattttgact ttaacagatt ccactgccac ttctcaccac gtgactggca gcgactcatt 900
aacaacaact ggggattccg gcccaagaaa ctcagcttca agctcttcaa catccaagtt 960
aaagaggtca cgcagaacga tggcacgacg actattgcca ataaccttac cagcacggtt 1020
caagtgttta cggactcgga gtatcagctc ccgtacgtgc tcgggtcggc gcaccaaggc 1080
tgtctcccgc cgtttccagc ggacgtcttc atggtccctc agtatggata cctcaccctg 1140
aacaacggaa gtcaagcggt gggacgctca tccttttact gcctggagta cttcccttcg 1200
cagatgctaa ggactggaaa taacttccaa ttcagctata ccttcgagga tgtacctttt 1260
cacagcagct acgctcacag ccagagtttg gatcgcttga tgaatcctct tattgatcag 1320
tatctgtact acctgaacag aacgcaagga acaacctctg gaacaaccaa ccaatcacgg 1380
ctgcttttta gccaggctgg gcctcagtct atgtctttgc aggccagaaa ttggctacct 1440
gggccctgct accggcaaca gagactttca aagactgcta acgacaacaa caacagtaac 1500
tttccttgga cagcggccag caaatatcat ctcaatggcc gcgactcgct ggtgaatcca 1560
ggaccagcta tggccagtca caaggacgat gaagaaaaat ttttccctat gcacggcaat 1620
ctaatatttg gcaaagaagg gacaacggca agtaacgcag aattagataa tgtaatgatt 1680
acggatgaag aagagattcg taccaccaat cctgtggcaa cagagcagta tggaactgtg 1740
gcaaataact tgcagagctc aaatacagct cccacgacta gaactgtcaa tgatcagggg 1800
gccttacctg gcatggtgtg gcaagatcgt gacgtgtacc ttcaaggacc tatctgggca 1860
aagattcctc acacggatgg acactttcat ccttctcctc tgatgggagg ctttggactg 1920
aaacatccgc ctcctcaaat catgatcaaa aatactccgg taccggcaaa tcctccgacg 1980
actttcagcc cggccaagtt tgcttcattt atcactcagt actccactgg acaggtcagc 2040
gtggaaattg agtgggagct acagaaagaa aacagcaaac gttggaatcc agagattcag 2100
tacacttcca actacaacaa gtctgttaat gtggacttta ctgtagacac taatggtgtt 2160
tatagtgaac ctcgccccat tggcacccgt taccttaccc gtcccctgta a          2211

<210> 429
<211> 736
<212> PRT
<213> Artificial Sequence

<220> 
<223> AAV-LK03 Capsid

<400> 429
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser
 1               5                  10                  15      
Glu Gly Ile Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro
            20                  25                  30          
Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro
    50                  55                  60                  
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp
65                  70                  75                  80  
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro
        115                 120                 125             
Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg
    130                 135                 140                 
Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly
145                 150                 155                 160 
Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr
                165                 170                 175     
Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro
            180                 185                 190         
Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu
                245                 250                 255     
Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr
            260                 265                 270         
Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His
        275                 280                 285             
Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp
    290                 295                 300                 
Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val
305                 310                 315                 320 
Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu
                325                 330                 335     
Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr
            340                 345                 350         
Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp
        355                 360                 365             
Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser
    370                 375                 380                 
Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser
385                 390                 395                 400 
Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu
                405                 410                 415     
Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg
            420                 425                 430         
Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr
        435                 440                 445             
Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser
    450                 455                 460                 
Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro
465                 470                 475                 480 
Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn
                485                 490                 495     
Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn
            500                 505                 510         
Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys
        515                 520                 525             
Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly
    530                 535                 540                 
Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile
545                 550                 555                 560 
Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln
                565                 570                 575     
Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr
            580                 585                 590         
Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln
        595                 600                 605             
Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His
    610                 615                 620                 
Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu
625                 630                 635                 640 
Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala
                645                 650                 655     
Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr
            660                 665                 670         
Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln
        675                 680                 685             
Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn
    690                 695                 700                 
Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val
705                 710                 715                 720 
Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu
                725                 730                 735     


<210> 430
<211> 7333
<212> DNA
<213> Artificial Sequence

<220> 
<223> KP1 Vector

<220> 
<221> misc_feature   
<222> (6)...(1871)
<223> rep

<220> 
<221> misc_feature   
<222> (1888)...(4101)
<223> KP1 capsid

<400> 430
ccgccatgcc ggggttttac gagattgtga ttaaggtccc cagcgacctt gacgagcatc 60
tgcccggcat ttctgacagc tttgtgaact gggtggccga gaaggaatgg gagttgccgc 120
cagattctga catggatctg aatctgattg agcaggcacc cctgaccgtg gccgagaagc 180
tgcagcgcga ctttctgacg gaatggcgcc gtgtgagtaa ggccccggag gctcttttct 240
ttgtgcaatt tgagaaggga gagagctact tccacatgca cgtgctcgtg gaaaccaccg 300
gggtgaaatc catggttttg ggacgtttcc tgagtcagat tcgcgaaaaa ctgattcaga 360
gaatttaccg cgggatcgag ccgactttgc caaactggtt cgcggtcaca aagaccagaa 420
atggcgccgg aggcgggaac aaggtggtgg atgagtgcta catccccaat tacttgctcc 480
ccaaaaccca gcctgagctc cagtgggcgt ggactaatat ggaacagtat ttaagcgcct 540
gtttgaatct cacggagcgt aaacggttgg tggcgcagca tctgacgcac gtgtcgcaga 600
cgcaggagca gaacaaagag aatcagaatc ccaattctga tgcgccggtg atcagatcaa 660
aaacttcagc caggtacatg gagctggtcg ggtggctcgt ggacaagggg attacctcgg 720
agaagcagtg gatccaggag gaccaggcct catacatctc cttcaatgcg gcctccaact 780
cgcggtccca aatcaaggct gccttggaca atgcgggaaa gattatgagc ctgactaaaa 840
ccgcccccga ctacctggtg ggccagcagc ccgtggagga catttccagc aatcggattt 900
ataaaatttt ggaactaaac gggtacgatc cccaatatgc ggcttccgtc tttctgggat 960
gggccacgaa aaagttcggc aagaggaaca ccatctggct gtttgggcct gcaactaccg 1020
ggaagaccaa catcgcggag gccatagccc acactgtgcc cttctacggg tgcgtaaact 1080
ggaccaatga gaactttccc ttcaacgact gtgtcgacaa gatggtgatc tggtgggagg 1140
aggggaagat gaccgccaag gtcgtggagt cggccaaagc cattctcgga ggaagcaagg 1200
tgcgcgtgga ccagaaatgc aagtcctcgg cccagataga cccgactccc gtgatcgtca 1260
cctccaacac caacatgtgc gccgtgattg acgggaactc aacgaccttc gaacaccagc 1320
agccgttgca agaccggatg ttcaaatttg aactcacccg ccgtctggat catgactttg 1380
ggaaggtcac caagcaggaa gtcaaagact ttttccggtg ggcaaaggat cacgtggttg 1440
aggtggagca tgaattctac gtcaaaaagg gtggagccaa gaaaagaccc gcccccagtg 1500
acgcagatat aagtgagccc aaacgggtgc gcgagtcagt tgcgcagcca tcgacgtcag 1560
acgcggaagc ttcgatcaac tacgcagaca ggtaccaaaa caaatgttct cgtcacgtgg 1620
gcatgaatct gatgctgttt ccctgcagac aatgcgagag aatgaatcag aattcaaata 1680
tctgcttcac tcacggacag aaagactgtt tagagtgctt tcccgtgtca gaatctcaac 1740
ccgtttctgt cgtcaaaaag gcgtatcaga aactgtgcta cattcatcat atcatgggaa 1800
aggtgccaga cgcttgcact gcctgcgatc tggtcaatgt ggatttggat gactgcatct 1860
ttgaacaata aatgatttaa atcaggtatg gctgccgatg gttatcttcc agattggctc 1920
gaggacactc tctctgaagg aataagacag tggtggaagc tcaaacctgg cccaccacca 1980
ccaaagcccg cagagcggca taaggacgac agcaggggtc ttgtgcttcc gggttacaaa 2040
tacctcggac ccggcaacgg actcgacaag ggggagcccg tcaacgcggc ggacgcagcg 2100
gccctcgagc acgacaaggc ctacgaccag cagctcaaag cgggtgacaa tccgtacctg 2160
cggtataacc acgccgacgc cgagtttcag gagcgtctgc aagaagatac gtcttttggg 2220
ggcaacctcg ggcgagcagt cttccaggcc aagaagcggg ttctcgaacc tctcggtctg 2280
gttgaggaac ctgttaagac ggctccggga aaaaagaggc cggtagagca ctctcctgtg 2340
gagccagact cctcctcggg aaccggaaag gcgggccagc agcctgcgag gaagcgactc 2400
aactttggtc agactggaga caccgactcc gccgctgacc cccagcctct cggagaacca 2460
ccagcagccc cctctggtct gggaactggt acaatggctg caggcggtgg cgctccaatg 2520
gcagacaata acgaaggcgc cgacggagtg ggtaatgcct cgggaaattg gcattgcgat 2580
tccacatggc tgggcgacag agtcatcacc accagcaccc gcacctgggc cttgcccacc 2640
tacaataacc acctctacaa gcaaatctcc agtgcttcaa cgggggccag caacgacaac 2700
cactacttcg gctacagcac cccctggggg tactttgact tcaaccgctt ccactgccac 2760
ttctcaccac gtgactggca aagactcatc aacaacaact ggggattccg gcccaagaga 2820
ctcaacttca agctcttcaa catccaggtc aaggaggtca cgcagaatga aggcaccaag 2880
accatcgcca ataaccttac cagcacggtt caggtgttta ctgactcgga gtaccagctg 2940
ccgtacgttc tcggctctgc ccaccagggc tgcctgcctc cgttcccggc ggacgtgttc 3000
atgattccgc agtacggcta cctaacgctc aacaatggca gccaggcgat gggtcgctcg 3060
tccttctact gcctggagta ctttccgtcg cagatgctga gaaccggcaa caacttccag 3120
tttacttaca ccttcgagga cgtgcctttc cacagcagct acgctcacag ccagagtttg 3180
gatcgcttga tgaatcctct tattgatcag tatctgtact acctgaacag aacgcaagga 3240
acaacctctg gaacaaccaa ccaatcacgg ctgcttttta gccaggctgg gcctcagtct 3300
atgtctttgc aggccagaaa ttggctacct gggccctgct accggcaaca gagactttca 3360
aagactgcta acgacaacaa caacagtaac tttccttgga cagcggccag caaatatcat 3420
ctcaatggcc gcgactcgct ggtgaatcca ggaccagcta tggccagtca caaggacgat 3480
gaagaaaaat ttttccctat gcacggcaat ctaatatttg gcaaagaagg gacaacggca 3540
agtaacgcag aattagataa tgtaatgatt acggatgaag aagagattcg taccaccaat 3600
cctgtggcaa cagagcagta tggaactgtg gcaaataact tgcagagctc aaatacagct 3660
cccacgacta gaactgtcaa tgatcagggg gccttacctg gcatggtgtg gcaagatcgt 3720
gacgtgtacc ttcaaggacc tatctgggca aagattcctc acacggatgg acactttcat 3780
ccttctcctc tgatgggcgg ctttggcctg aaacatcctc cgcctcagat cctgatcaag 3840
aacacgcctg tacctgcgga tcctccaacg gccttcaaca aggacaagct gaactctttc 3900
atcacccagt attctactgg ccaagtcagc gtggagatcg agtgggagct gcagaaggaa 3960
aacagcaagc gctggaaccc cgagatccag tacacctcca actactacaa atctacaagt 4020
gtggactttg ctgttaatac agaaggcgtg tactctgaac cccgccccat tggcacccgt 4080
tacctcaccc gtaatctgta attgcctgtt aatcaataaa ccggttgatt cgtttcagtt 4140
gaactttggt ctctgcgaag ggcgaattcg tttaaacctg caggactaga ggtcctgtat 4200
tagaggtcac gtgagtgttt tgcgacattt tgcgacacca tgtggtcacg ctgggtattt 4260
aagcccgagt gagcacgcag ggtctccatt ttgaagcggg aggtttgaac gcgcagccgc 4320
caagccgaat tctgcagata tccatcacac tggcggccgc tcgactagag cggccgccac 4380
cgcggtggag ctccagcttt tgttcccttt agtgagggtt aattgcgcgc ttggcgtaat 4440
catggtcata gctgtttcct gtgtgaaatt gttatccgct cacaattcca cacaacatac 4500
gagccggaag cataaagtgt aaagcctggg gtgcctaatg agtgagctaa ctcacattaa 4560
ttgcgttgcg ctcactgccc gctttccagt cgggaaacct gtcgtgccag ctgcattaat 4620
gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc gcttcctcgc 4680
tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg 4740
cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg tgagcaaaag 4800
gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc 4860
gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga aacccgacag 4920
gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct cctgttccga 4980
ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc 5040
atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg 5100
tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat cgtcttgagt 5160
ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac aggattagca 5220
gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac tacggctaca 5280
ctagaagaac agtatttggt atctgcgctc tgctgaagcc agttaccttc ggaaaaagag 5340
ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt tttgtttgca 5400
agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg 5460
ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg agattatcaa 5520
aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca atctaaagta 5580
tatatgagta aacttggtct gacagttacc aatgcttaat cagtgaggca cctatctcag 5640
cgatctgtct atttcgttca tccatagttg cctgactccc cgtcgtgtag ataactacga 5700
tacgggaggg cttaccatct ggccccagtg ctgcaatgat accgcgagac ccacgctcac 5760
cggctccaga tttatcagca ataaaccagc cagccggaag ggccgagcgc agaagtggtc 5820
ctgcaacttt atccgcctcc atccagtcta ttaattgttg ccgggaagct agagtaagta 5880
gttcgccagt taatagtttg cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac 5940
gctcgtcgtt tggtatggct tcattcagct ccggttccca acgatcaagg cgagttacat 6000
gatcccccat gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc gttgtcagaa 6060
gtaagttggc cgcagtgtta tcactcatgg ttatggcagc actgcataat tctcttactg 6120
tcatgccatc cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag tcattctgag 6180
aatagtgtat gcggcgaccg agttgctctt gcccggcgtc aatacgggat aataccgcgc 6240
cacatagcag aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct 6300
caaggatctt accgctgttg agatccagtt cgatgtaacc cactcgtgca cccaactgat 6360
cttcagcatc ttttactttc accagcgttt ctgggtgagc aaaaacagga aggcaaaatg 6420
ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat actcatactc ttcctttttc 6480
aatattattg aagcatttat cagggttatt gtctcatgag cggatacata tttgaatgta 6540
tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg ccacctaaat 6600
tgtaagcgtt aatattttgt taaaattcgc gttaaatttt tgttaaatca gctcattttt 6660
taaccaatag gccgaaatcg gcaaaatccc ttataaatca aaagaataga ccgagatagg 6720
gttgagtgtt gttccagttt ggaacaagag tccactatta aagaacgtgg actccaacgt 6780
caaagggcga aaaaccgtct atcagggcga tggcccacta cgtgaaccat caccctaatc 6840
aagttttttg gggtcgaggt gccgtaaagc actaaatcgg aaccctaaag ggagcccccg 6900
atttagagct tgacggggaa agccggcgaa cgtggcgaga aaggaaggga agaaagcgaa 6960
aggagcgggc gctagggcgc tggcaagtgt agcggtcacg ctgcgcgtaa ccaccacacc 7020
cgccgcgctt aatgcgccgc tacagggcgc gtcccattcg ccattcaggc tgcgcaactg 7080
ttgggaaggg cgatcggtgc gggcctcttc gctattacgc cagctggcga aagggggatg 7140
tgctgcaagg cgattaagtt gggtaacgcc agggttttcc cagtcacgac gttgtaaaac 7200
gacggccagt gagcgcgcgt aatacgactc actatagggc gaattgggta ccgggccccc 7260
cctcgatcga ggtcgacggt atcgggggag ctcgcagggt ctccattttg aagcgggagg 7320
tttgaacgcg cag                                                    7333

<210> 431
<211> 1856
<212> DNA
<213> Artificial Sequence

<220> 
<223> KP1 AAV2 rep

<400> 431
atgccggggt tttacgagat tgtgattaag gtccccagcg accttgacga gcatctgccc 60
ggcatttctg acagctttgt gaactgggtg gccgagaagg aatgggagtt gccgccagat 120
tctgacatgg atctgaatct gattgagcag gcacccctga ccgtggccga gaagctgcag 180
cgcgactttc tgacggaatg gcgccgtgtg agtaaggccc cggaggctct tttctttgtg 240
caatttgaga agggagagag ctacttccac atgcacgtgc tcgtggaaac caccggggtg 300
aaatccatgg ttttgggacg tttcctgagt cagattcgcg aaaaactgat tcagagaatt 360
taccgcggga tcgagccgac tttgccaaac tggttcgcgg tcacaaagac cagaaatggc 420
gccggaggcg ggaacaaggt ggtggatgag tgctacatcc ccaattactt gctccccaaa 480
acccagcctg agctccagtg ggcgtggact aatatggaac agtatttaag cgcctgtttg 540
aatctcacgg agcgtaaacg gttggtggcg cagcatctga cgcacgtgtc gcagacgcag 600
gagcagaaca aagagaatca gaatcccaat tctgatgcgc cggtgatcag atcaaaaact 660
tcagccaggt acatggagct ggtcgggtgg ctcgtggaca aggggattac ctcggagaag 720
cagtggatcc aggaggacca ggcctcatac atctccttca atgcggcctc caactcgcgg 780
tcccaaatca aggctgcctt ggacaatgcg ggaaagatta tgagcctgac taaaaccgcc 840
cccgactacc tggtgggcca gcagcccgtg gaggacattt ccagcaatcg gatttataaa 900
attttggaac taaacgggta cgatccccaa tatgcggctt ccgtctttct gggatgggcc 960
acgaaaaagt tcggcaagag gaacaccatc tggctgtttg ggcctgcaac taccgggaag 1020
accaacatcg cggaggccat agcccacact gtgcccttct acgggtgcgt aaactggacc 1080
aatgagaact ttcccttcaa cgactgtgtc gacaagatgg tgatctggtg ggaggagggg 1140
aagatgaccg ccaaggtcgt ggagtcggcc aaagccattc tcggaggaag caaggtgcgc 1200
gtggaccaga aatgcaagtc ctcggcccag atagacccga ctcccgtgat cgtcacctcc 1260
aacaccaaca tgtgcgccgt gattgacggg aactcaacga ccttcgaaca ccagcagccg 1320
ttgcaagacc ggatgttcaa atttgaactc acccgccgtc tggatcatga ctttgggaag 1380
gtcaccaagc aggaagtcaa agactttttc cggtgggcaa aggatcacgt ggttgaggtg 1440
gagcatgaat tctacgtcaa aaagggtgga gccaagaaaa gacccgcccc cagtgacgca 1500
gatataagtg agcccaaacg ggtgcgcgag tcagttgcgc agccatcgac gtcagacgcg 1560
gaagcttcga tcaactacgc agacaggtac caaaacaaat gttctcgtca cgtgggcatg 1620
aatctgatgc tgtttccctg cagacaatgc gagagaatga atcagaattc aaatatctgc 1680
ttcactcacg gacagaaaga ctgtttagag tgctttcccg tgtcagaatc tcaacccgtt 1740
tctgtcgtca aaaaggcgta tcagaaactg tgctacattc atcatatcat gggaaaggtg 1800
ccagacgctt gcactgcctg cgatctggtc aatgtggatt tggatgactg catctt     1856

<210> 432
<211> 618
<212> PRT
<213> Artificial Sequence

<220> 
<223> KP1 AAV2 rep

<400> 432
Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp
 1               5                  10                  15      
Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu
            20                  25                  30          
Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile
        35                  40                  45              
Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu
    50                  55                  60                  
Thr Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val
65                  70                  75                  80  
Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val Leu Val Glu
                85                  90                  95      
Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile
            100                 105                 110         
Arg Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu
        115                 120                 125             
Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly
    130                 135                 140                 
Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys
145                 150                 155                 160 
Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu
                165                 170                 175     
Ser Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val Ala Gln His
            180                 185                 190         
Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn
        195                 200                 205             
Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr
    210                 215                 220                 
Met Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Ser Glu Lys
225                 230                 235                 240 
Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala
                245                 250                 255     
Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys
            260                 265                 270         
Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln
        275                 280                 285             
Pro Val Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu
    290                 295                 300                 
Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala
305                 310                 315                 320 
Thr Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala
                325                 330                 335     
Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro
            340                 345                 350         
Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp
        355                 360                 365             
Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala
    370                 375                 380                 
Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg
385                 390                 395                 400 
Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val
                405                 410                 415     
Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser
            420                 425                 430         
Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe
        435                 440                 445             
Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln
    450                 455                 460                 
Glu Val Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val
465                 470                 475                 480 
Glu His Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala
                485                 490                 495     
Pro Ser Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val
            500                 505                 510         
Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp
        515                 520                 525             
Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu
    530                 535                 540                 
Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys
545                 550                 555                 560 
Phe Thr His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu
                565                 570                 575     
Ser Gln Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr
            580                 585                 590         
Ile His His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp
        595                 600                 605             
Leu Val Asn Val Asp Leu Asp Asp Cys Ile
    610                 615             


<210> 433
<211> 1438
<212> DNA
<213> Artificial Sequence

<220> 
<223> partial FIX intron

<400> 433
ggtttgtttc cttttttaaa atacattgag tatgcttgcc ttttagatat agaaatatct 60
gatgctgtct tcttcactaa attttgatta catgatttga cagcaatatt gaagagtcta 120
acagccagca cgcaggttgg taagtactgg ttctttgtta gctaggtttt cttcttcttc 180
atttttaaaa ctaaatagat cgacaatgct tatgatgcat ttatgtttaa taaacactgt 240
tcagttcatg atttggtcat gtaattcctg ttagaaaaca ttcatctcct tggtttaaaa 300
aaattaaaag tgggaaaaca aagaaatagc agaatatagt gaaaaaaaat aaccacatta 360
tttttgtttg gacttaccac tttgaaatca aaatgggaaa caaaagcaca aacaatggcc 420
ttatttacac aaaaagtctg attttaagat atatgacatt tcaaggtttc agaagtatgt 480
aatgaggtgt gtctctaatt ttttaaatta tatatcttca atttaaagtt ttagttaaaa 540
cataaagatt aacctttcat tagcaagctg ttagttatca ccaaagcttt tcatggatta 600
ggaaaaaatc attttgtctc tatgtcaaac atcttggagt tgatatttgg ggaaacacaa 660
tactcagttg agttccctag gggagaaaag caagcttaag aattgacata aagagtagga 720
agttagctaa tgcaacatat atcactttgt tttttcacaa ctacagtgac tttatgtatt 780
tcccagagga aggcatacag ggaagaaatt atcccatttg gacaaacagc atgttctcac 840
aggaagcatt tatcacactt acttgtcaac tttctagaat caaatctagt agctgacagt 900
accaggatca ggggtgccaa ccctaagcac ccccagaaag ctgactggcc ctgtggttcc 960
cactccagac atgatgtcag ctgtgaaatc gacgtcgctg gaccataatt aggcttctgt 1020
tcttcaggag acatttgttc aaagtcattt gggcaaccat attctgaaaa cagcccagcc 1080
agggtgatgg atcactttgc aaagatcctc aatgagctat tttcaagtga tgacaaagtg 1140
tgaagttaac cgctcatttg agaactttct ttttcatcca aagtaaattc aaatatgatt 1200
agaaatctga ccttttatta ctggaattct cttgactaaa agtaaaattg aattttaatt 1260
cctaaatctc catgtgtata cagtactgtg ggaacatcac agattttggc tccatgccct 1320
aaagagaaat tggctttcag attatttgga ttaaaaacaa agactttctt aagagatgta 1380
aaattttcat gatgttttct tttttgctaa aactaaagaa ttattctttt acatttca   1438

<210> 434
<211> 6157
<212> DNA
<213> Artificial Sequence

<220> 
<223> FIX intron I

<400> 434
gtttgtttcc ttttttaaaa tacattgagt atgcttgcct tttagatata gaaatatctg 60
atgctgtctt cttcactaaa ttttgattac atgatttgac agcaatattg aagagtctaa 120
cagccagcac gcaggttggt aagtactggt tctttgttag ctaggttttc ttcttcttca 180
tttttaaaac taaatagatc gacaatgctt atgatgcatt tatgtttaat aaacactgtt 240
cagttcatga tttggtcatg taattcctgt tagaaaacat tcatctcctt ggtttaaaaa 300
aattaaaagt gggaaaacaa agaaatagca gaatatagtg aaaaaaaata accacattat 360
ttttgtttgg acttaccact ttgaaatcaa aatgggaaac aaaagcacaa acaatggcct 420
tatttacaca aaaagtctga ttttaagata tatgacattt caaggtttca gaagtatgta 480
atgaggtgtg tctctaattt tttaaattat atatcttcaa tttaaagttt tagttaaaac 540
ataaagatta acctttcatt agcaagctgt tagttatcac caaagctttt catggattag 600
gaaaaaatca ttttgtctct atgtcaaaca tcttggagtt gatatttggg gaaacacaat 660
actcagttga gttccctagg ggagaaaagc aagcttaaga attgacataa agagtaggaa 720
gttagctaat gcaacatata tcactttgtt ttttcacaac tacagtgact ttatgtattt 780
cccagaggaa ggcatacagg gaagaaatta tcccatttgg acaaacagca tgttctcaca 840
ggaagcattt atcacactta cttgtcaact ttctagaatc aaatctagta gctgacagta 900
ccaggatcag gggtgccaac cctaagcacc cccagaaagc tgactggccc tgtggttccc 960
actccagaca tgatgtcagc tgtgaaatca gactgaaatg ctgaaataac gataaaaaaa 1020
aatacagagg ttaaactagc aaagtgagta aagtcaaggg ataaagaaaa tttgttggaa 1080
aactcacaaa gcaggacata aagcaaggcc attagatata tctcattagt gtgacatctg 1140
ggaggacaaa gcatccaaac cctttcttct atataagtgg tgagatgatg aaggttgtaa 1200
gagggcttct gcccccttga agacttcaga tgctggggaa aggatagata agaataagga 1260
tgaaccaggc ttttggagcc tgggaaataa tgactagcga taaacctgaa gggaagttaa 1320
gtatacgatc cccagataat actaaggaga aaggcaatgt gattctgcag ccattgtagc 1380
cagagataat aagcccttga ggaaggggcc aggggaattt ttctaaggat agacagtatt 1440
aatgcagcac tctcttctgc tattaaactc tcattggctt ctaaaaggag tttcggtgag 1500
tgatttgctg agatgttgca ttttcatggc tgctgccttt aggtattatt gcaacagttt 1560
ggaattttga aattaaaaca gttctgtaaa accagtttag ttttgtaaag tgtatgcatc 1620
aaagatgtcc ttcattcaga cattactgag ttacaactat ggtgccaggt actgtgtcag 1680
ggtactaggg gtatggggat aaaccagact ccctctttga tctaaagcag catgaggcca 1740
ggtgagaggt ttcaatataa tgtgataaaa tgtgcactag gtactaaggg atcatagaga 1800
aaggaacaca ttaaatgggg aaacaattga tagagagaga atattttcat ctgggtctta 1860
aaagatgagt aggcgttctc tctctttaaa tgtctgatat aagggcattt tatgcaaaga 1920
ggatcactcg tgcaaagact cagatttgca agaacgtgag gtatttcagg agttttgtat 1980
ggttccatat ggactatgac aagtgagaca ggtaaactag gcagagctgg tcatcagata 2040
atgaagtcat taacctaagg agattggaca ataaaatgca atatggaggt atcgaagtat 2100
aaacataagg agtaccactg atggctgatt taggatgccc agtctggcaa cacgctaatg 2160
aaatgatagt gggggagggg gccgtaccaa gactaggaga gagcagtcct gagactattg 2220
caattatctg cgggagacat aaaggctaga acctgaacag tagcagtaca aaaaaagagg 2280
ggagttcaaa tgatattaag gaagtagaag tggtatgact taaccatctg ggtatggaag 2340
gggaaatggc tagagtcttg gggactttgt gtttgatgtg attatggacc acagaataat 2400
gtctaagaga actggctctt tagtctgact gccagagtct gaatcctgaa tgttttagta 2460
tgttaccttg ggcaaagccc ttagcctcta tgaatctatc ttcctcattc ataaaaataa 2520
gatgacagtg cctatctcgt gggacttttg tgaggatgaa gtgagataat ggatgcaaag 2580
ttactgagca cagtgtccaa cacagcagaa gcattacata tacattagct attactggct 2640
acattatgat atacagttag ggagttggaa agataatctg aaattcagga gacgtatctg 2700
actataggtg agtatttgga actcattgtt ctgtaaacag tagttacagc cacgtgtgtg 2760
ggcatctgga gagtgagcat ggatattgtg atacctagta cagtgcctgg cagtagtggt 2820
tgtatgctca gtaaattttg ttgacagggt cagggccgga ctagactgtg gtaagcaagg 2880
cctgtagggc ataaatatac ttgtatgccc cgagaagtga ggacctctta aatattgtgc 2940
cctacatgcc ttgtttggtt cactcttgtc ccagccctag caagtatata taaggtgaaa 3000
aaggaaaaag ctgaggctgg agcctgggag aaccctggac atttaagggc catggagagg 3060
aacaggagtt aatcaattca agtgctggat ggataacagg agttagagca aagcggggaa 3120
ccagaataga gtgattatta taaaaagagt ttcctaaaaa gggagagatc aacaattaga 3180
aattatttag agcagccagt aaatacataa actcaaaatt attctttagg tcattcctga 3240
ttgtgacaat agtcatttca ttatataaat gtgattaagg aaggaaaaga gctacacaga 3300
agttattaaa gagctaaaga gaattgagaa atttaaaaca gaagaaagta gggccaacat 3360
gaaaggagta gggagaaaaa gagataacca gcatattgtc tcactgatcc tgccaacacc 3420
tgtgagatag atattcttat tatactactg ttaaacctaa tttacatttg acaaagttaa 3480
ggttcagagc ttgtgtgact tgtccaaggt cacaggtcta gaggaggcag atacttgatt 3540
caaacctatt tctgtctgat ctgattctaa agtctgtttt ttcactcaac cacactgtac 3600
agtcagctct ccttgtgagt tccacagcca cagattcaat taactgcaga tcaaaaatat 3660
tcaagaaaaa aatggatggt tgcatctcta ctgaacatgt acagactctt ttatctttca 3720
ttattcccta aacaatacag cataacaact atttacatag catttacatt gtattagcta 3780
ttaagagaaa cctagagatg atttaaagta caaaggagga tgtgtttagg ttatatgcaa 3840
atagtaagcc atttttatat cggagacttg agcatccaca gatcttgata tttgcagggg 3900
gtcttgccac caattttcca tggatactga ggaacgactg taaatggatg caggcatgga 3960
tgctatttag gagtgtccag ggccaagtaa atgagttgct gagcagagag gtgggtggag 4020
gctgtgaggc atcaatatgt ggtggcatcc atctgcattt tggtgatttt tttccttcac 4080
agtcctcggc tgtctgggaa gagaaggatg aaggcagatg gctgctccaa tttaggggct 4140
aggattgcag ggtgggcaca gcattgcaaa cgagtgaagg aaattgagaa atatggccaa 4200
tgaagagttg aagagaggcc tggcatggtg gctcacacct ataatcccag cactttcaga 4260
ggcccaggca ggcagatcac ttgaggtcag gagttcgaca ccagcctggc caacaaggtg 4320
aaatggtgaa accccggctt tactaaaaat acaaaaatta gctgggcatg gtggcgggtg 4380
cctgtaatcc cagctacttg ggaggctgag gcaggagaat agcttgaacc tgggagatgg 4440
aggttgcagt gagctgagat cgcaccactg cactccagcc tgggcgacag agcaagactc 4500
tgtcaaaaaa aaaagagttg aagagaaaaa gtctaggcta aattcaaaga aaaaaagtga 4560
gcccaaaagg aacttgcaga gcaagggaaa agcagggatg tcaagggact agaacactcc 4620
ataaagtgaa cagctgcaat gaaaataagg gaagaaagtt tagttcatct ccgtttcttt 4680
cctttccttt ttactttcct ttctcttcct ttttggagtt aatcaggaag tagtcccaaa 4740
taccccagaa agttcatctt ataagccctt ggtcctcttg agatggtatc agatatattg 4800
ctagaccctt gaagaaagga acaactccag gcaacttctt gagtccctgt tattaatttt 4860
atacatacac acacatatat gtatatacat gaaaacacac aaacacatgt gtgtgtatac 4920
agccatgcat tccttaacaa tggggatata ttctgagaaa tgtgtcatta agcaatttca 4980
tcattgtgcg aacataatag agtgtactta cctaaaccta aatggtatag cttactacat 5040
acctaggttg tattgatgtg gcctattgct cctaggctcc tgggctgcaa acctgtacag 5100
catgtgactg tactgaacac tgtaggcaat ggtaacagtg gtatttgtgt atctaaacat 5160
agaaaaggta cagtgaaaat acagtattat aaccttatgg gaccactgtc gtataatgtg 5220
gtccatcatt gaccaaaatg tcattgtgca gcaaatgatt atctcatata tatatatata 5280
tgatatgata tatatgatat atatgtgtgt gtatatatgt atacatatat atgtgtacat 5340
atatgtatac atatatacac acacatatat atgtacacac atatatgtat atatatgtac 5400
acacatatat gtatatatat atgtacacac acacacatag agagagagag agaggagagg 5460
agaggaagga gggagggaag gagaaatatg attcagatag agacatctat cctccagagt 5520
tcaggagtgt ctcttcagac taggtagatg tagcttaaaa aaaacatatc ctgaattcta 5580
gagagatgct taaatcactg caattcctat aacacttgcc aaccaaaggt gctgttgatc 5640
tgaaattgct tttttaaatt aatgcagtga tttttcttta acatctagtg acagacactg 5700
gggtcacatt tgcagctgga ccataattag gcttctgttc ttcaggagac atttgttcaa 5760
agtcatttgg gcaaccatat tctgaaaaca gcccagccag ggtgatggat cactttgcaa 5820
agatcctcaa tgagctattt tcaagtgatg acaaagtgtg aagttaaccg ctcatttgag 5880
aactttcttt ttcatccaaa gtaaattcaa atatgattag aaatctgacc ttttattact 5940
ggaattctct tgactaaaag taaaattgaa ttttaattcc taaatctcca tgtgtataca 6000
gtactgtggg aacatcacag attttggctc catgccctaa agagaaattg gctttcagat 6060
tatttggatt aaaaacaaag actttcttaa gagatgtaaa attttcatga tgttttcttt 6120
tttgctaaaa ctaaagaatt attcttttac atttcag                          6157

<210> 435
<211> 119
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV2 Left ITR

<400> 435
ctgcgcgctc gctcgctcac tgaggccgcc cgggcgtcgg gcgacctttg gtcgcccggc 60
ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcct  119

<210> 436
<211> 130
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV2 Right ITR

<400> 436
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg 60
ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc 120
gagcgcgcag                                                        130

<210> 437
<211> 119
<212> DNA
<213> Artificial Sequence

<220> 
<223> short AAV2 Right ITR

<400> 437
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg 60
ccgggcgacc aaaggtcgcc cgacgcccgg gcggcctcag tgagcgagcg agcgcgcag  119

<210> 438
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> ApoE/C1 gene locus (enhancer)

<400> 438
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc 60
ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc 120
tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc 180
cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc 240
tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt 300
ggtttaggta gtgtgagagg g                                           321

<210> 439
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Serpin AI (liver specific enhancer)

<400> 439
gggggaggct gctggtgaat attaaccaag gtcaccccag ttatcggagg agcaaacagg 60
ggctaagtcc ac                                                     72

<210> 440
<211> 393
<212> DNA
<213> Artificial Sequence

<220> 
<223> huSerpin A antitrypsin liver specific promoter
      (partial)

<400> 440
gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta 60
agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac 120
gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg aagctgtaca 180
ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact 240
tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct 300
cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct 360
cagcttcagg caccaccact gacctgggac agt                              393

<210> 441
<211> 224
<212> DNA
<213> Artificial Sequence

<220> 
<223> transthyretin (TTR ) liver specific promoter

<400> 441
gtctgtctgc acatttcgta gagcgagtgt tccgatactc taatctccct aggcaaggtt 60
catatttgtg taggttactt attctccttt tgttgactaa gtcaataatc agaatcagca 120
ggtttggagt cagcttggca gggatcagca gcctgggttg gaaggagggg gtataaaagc 180
cccttcacca ggagaagccg tcacacagat ccacaagctc ctga                  224

<210> 442
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> Kozak

<400> 442
gccacc                                                            6

<210> 443
<211> 225
<212> DNA
<213> Artificial Sequence

<220> 
<223> bGHpolyA

<400> 443
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc 60
tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc 120
tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt 180
gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgg                 225

<210> 444
<211> 84
<212> DNA
<213> Homo sapiens

<220> 
<221> sig_peptide    
<222> (1)...(84)
<223> hFIX Signal Peptide

<400> 444
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta 60
ggatatctac tcagtgctga atgt                                        84

<210> 445
<211> 3
<212> DNA
<213> Homo sapiens

<220> 
<223> hFIX partial propeptide

<400> 445
aca                                                               3

<210> 446
<211> 51
<212> DNA
<213> Homo sapiens

<220> 
<223> hFIX Propeptide

<400> 446
gtttttcttg atcatgaaaa cgccaacaaa attctgaatc ggccaaagag g          51

<210> 447
<211> 7585
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV-human wild type FIX mouse optimized vector

<220> 
<221> repeat_region  
<222> (1597)...(1715)
<223> ITR

<220> 
<221> enhancer       
<222> (1781)...(2101)
<223> ApoE/C1

<220> 
<221> promoter       
<222> (2111)...(2503)
<223> huSerpin A antitrypsin liver specific promoter
      (partial)

<220> 
<221> misc_feature   
<222> (2598)...(2603)
<223> kozak


<220> 
<221> sig_peptide    
<222> (2604)...(2687)
<223> FIX signal sequence


<220> 
<221> misc_feature 
<222> (2688)...(2690) 
<223> FIX propeptide sequence


<220> 
<221> intron         
<222> (2691)...(4128)
<223> FIX partial intron 1


<220> 
<221> misc_feature 
<222> (4129)...(4179) 
<223> FIX propeptide sequence


<220> 
<221> misc_feature 
<222> (4180)...(5427) 
<223> FIX zymogen


<220> 
<221> polyA_signal   
<222> (5539)...(5763)
<223> bovine growth hormone polyadenylation signal


<220> 
<221> repeat_region  
<222> (5877)...(6006)
<223> ITR

<400> 447
gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg 60
acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg 120
gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag 180
ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg 240
gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct 300
cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac 360
agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact 420
catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga 480
tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt 540
cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct 600
gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc 660
taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc 720
ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc 780
tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg 840
ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt 900
cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg 960
agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg 1020
gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt 1080
atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag 1140
gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt 1200
gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta 1260
ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt 1320
cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc 1380
cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca 1440
acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc 1500
cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg 1560
accatgatta cgccaagctt gcatgcctgc aggcagctgc gcgctcgctc gctcactgag 1620
gccgcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag 1680
agagggagtg gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtaaag 1740
atctgatatc atcgatcgcg atgcattaat taagcggccg aggctcagag gcacacagga 1800
gtttctgggc tcaccctgcc cccttccaac ccctcagttc ccatcctcca gcagctgttt 1860
gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc tactcatgtc cctaaaatgg 1920
gcaaacattg caagcagcaa acagcaaaca cacagccctc cctgcctgct gaccttggag 1980
ctggggcaga ggtcagagac ctctctgggc ccatgccacc tccaacatcc actcgacccc 2040
ttggaatttc ggtggagagg agcagaggtt gtcctggcgt ggtttaggta gtgtgagagg 2100
ggtacccggg gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga 2160
gggccagcta agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg 2220
gacacaggac gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg 2280
aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag 2340
ccagtggact tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca 2400
ccagcagcct cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc 2460
cctgtctcct cagcttcagg caccaccact gacctgggac agtgaatgat ccccctgatc 2520
tgcggcctcg acggtatcga taagcttgat atcgaattct agtcgtcgac cactttcaca 2580
atctgctagc aaaggttgcc accatgcagc gcgtgaacat gattatggcc gagagccctg 2640
gcctgatcac catctgcctg ctgggctacc tgctgagcgc cgagtgtaca ggtttgtttc 2700
cttttttaaa atacattgag tatgcttgcc ttttagatat agaaatatct gatgctgtct 2760
tcttcactaa attttgatta catgatttga cagcaatatt gaagagtcta acagccagca 2820
cgcaggttgg taagtactgg ttctttgtta gctaggtttt cttcttcttc atttttaaaa 2880
ctaaatagat cgacaatgct tatgatgcat ttatgtttaa taaacactgt tcagttcatg 2940
atttggtcat gtaattcctg ttagaaaaca ttcatctcct tggtttaaaa aaattaaaag 3000
tgggaaaaca aagaaatagc agaatatagt gaaaaaaaat aaccacatta tttttgtttg 3060
gacttaccac tttgaaatca aaatgggaaa caaaagcaca aacaatggcc ttatttacac 3120
aaaaagtctg attttaagat atatgacatt tcaaggtttc agaagtatgt aatgaggtgt 3180
gtctctaatt ttttaaatta tatatcttca atttaaagtt ttagttaaaa cataaagatt 3240
aacctttcat tagcaagctg ttagttatca ccaaagcttt tcatggatta ggaaaaaatc 3300
attttgtctc tatgtcaaac atcttggagt tgatatttgg ggaaacacaa tactcagttg 3360
agttccctag gggagaaaag caagcttaag aattgacata aagagtagga agttagctaa 3420
tgcaacatat atcactttgt tttttcacaa ctacagtgac tttatgtatt tcccagagga 3480
aggcatacag ggaagaaatt atcccatttg gacaaacagc atgttctcac aggaagcatt 3540
tatcacactt acttgtcaac tttctagaat caaatctagt agctgacagt accaggatca 3600
ggggtgccaa ccctaagcac ccccagaaag ctgactggcc ctgtggttcc cactccagac 3660
atgatgtcag ctgtgaaatc gacgtcgctg gaccataatt aggcttctgt tcttcaggag 3720
acatttgttc aaagtcattt gggcaaccat attctgaaaa cagcccagcc agggtgatgg 3780
atcactttgc aaagatcctc aatgagctat tttcaagtga tgacaaagtg tgaagttaac 3840
cgctcatttg agaactttct ttttcatcca aagtaaattc aaatatgatt agaaatctga 3900
ccttttatta ctggaattct cttgactaaa agtaaaattg aattttaatt cctaaatctc 3960
catgtgtata cagtactgtg ggaacatcac agattttggc tccatgccct aaagagaaat 4020
tggctttcag attatttgga ttaaaaacaa agactttctt aagagatgta aaattttcat 4080
gatgttttct tttttgctaa aactaaagaa ttattctttt acatttcagt gttcctggac 4140
cacgagaacg ccaacaagat cctgaacaga cccaagagat acaacagcgg caagctggaa 4200
gagttcgtgc agggcaacct ggaacgcgag tgcatggaag agaagtgcag cttcgaagag 4260
gccagagagg tgttcgagaa caccgagaga accaccgagt tctggaagca gtacgtggac 4320
ggcgaccagt gcgagagcaa cccttgtctg aacggcggca gctgcaagga cgacatcaac 4380
agctacgagt gctggtgccc cttcggcttc gagggcaaga actgcgagct ggacgtgacc 4440
tgcaacatca agaacggcag atgcgagcag ttctgcaaga acagcgccga caacaaggtc 4500
gtgtgctcct gcaccgaggg ctacagactg gccgagaacc agaagtcctg cgagcccgct 4560
gtgcctttcc catgcggaag agtgtccgtg tcccagacca gcaagctgac cagagccgag 4620
acagtgttcc ccgacgtgga ctacgtgaac agcaccgagg ccgagacaat cctggacaac 4680
atcacccaga gcacccagtc cttcaacgac ttcaccagag tcgtgggcgg cgaggatgct 4740
aagcctggcc agttcccgtg gcaggtggtg ctgaacggaa aggtggacgc cttctgcggc 4800
ggctccatcg tgaacgagaa gtggatcgtg acagccgccc actgcgtgga aaccggcgtg 4860
aagatcacag tggtggccgg cgagcacaac atcgaggaaa ccgagcacac agagcagaaa 4920
agaaacgtga tcaggatcat cccccaccac aactacaacg ccgccatcaa caagtacaac 4980
cacgatatcg ccctgctgga actggacgag cccctggtgc tgaatagcta cgtgaccccc 5040
atctgtatcg ccgacaaaga gtacaccaac atctttctga agttcggcag cggctacgtg 5100
tccggctggg gcagagtgtt tcacaagggc agatccgctc tggtgctgca gtacctgaga 5160
gtgcctctgg tggacagagc cacctgtctg agaagcacca agttcaccat ctacaacaac 5220
atgttctgcg ctggcttcca cgagggcggc agagactctt gtcagggcga ttctggcggc 5280
cctcacgtga cagaggtgga aggcaccagc tttctgaccg gcatcatcag ctggggcgag 5340
gaatgcgcca tgaaggggaa gtacggcatc tacaccaagg tgtccagata cgtgaactgg 5400
atcaaagaaa agaccaagct gacataatga aagatggatt tccaaggtta attcattgga 5460
attgaaaatt aacagccccc cccccccccc cctgcagatc tcgagccgaa ttcctgcagc 5520
ccgggggatc agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc 5580
ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg 5640
aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg 5700
acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta 5760
tggcttctga ggcggaaaga accagctggg gctcgagatc cactagacta gtgtacacgc 5820
gtgatatcag atctgttacg tagataagta gcatggcggg ttaatcatta actacaagga 5880
acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg 5940
gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc 6000
gcgcagctgc ctgcaggtcg actctagagg atccccgggt accgagctcg aattcactgg 6060
ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg 6120
cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt 6180
cccaacagtt gcgcagcctg aatggcgaat ggcgcctgat gcggtatttt ctccttacgc 6240
atctgtgcgg tatttcacac cgcatacgtc aaagcaacca tagtacgcgc cctgtagcgg 6300
cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc 6360
ttagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc 6420
cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc 6480
gaccccaaaa aacttgattt gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg 6540
gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact 6600
ggaacaacac tcaactctat ctcgggctat tcttttgatt tataagggat tttgccgatt 6660
tcggtctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa 6720
atattaacgt ttacaatttt atggtgcact ctcagtacaa tctgctctga tgccgcatag 6780
ttaagccagc cccgacaccc gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc 6840
ccggcatccg cttacagaca agctgtgacc gtctccggga gctgcatgtg tcagaggttt 6900
tcaccgtcat caccgaaacg cgcgagacga aagggcctcg tgatacgcct atttttatag 6960
gttaatgtca tgataataat ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg 7020
cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga 7080
caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat 7140
ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca 7200
gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc 7260
gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca 7320
atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg 7380
caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca 7440
gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata 7500
accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag 7560
ctaaccgctt ttttgcacaa catgg                                       7585

<210> 448
<211> 7585
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV-human FIX  R318Y/R338E/T343R mouse optimized
      vector

<400> 448
gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg 60
acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg 120
gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag 180
ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg 240
gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct 300
cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac 360
agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact 420
catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga 480
tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt 540
cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct 600
gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc 660
taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc 720
ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc 780
tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg 840
ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt 900
cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg 960
agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg 1020
gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt 1080
atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag 1140
gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt 1200
gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta 1260
ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt 1320
cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc 1380
cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca 1440
acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc 1500
cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg 1560
accatgatta cgccaagctt gcatgcctgc aggcagctgc gcgctcgctc gctcactgag 1620
gccgcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag 1680
agagggagtg gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtaaag 1740
atctgatatc atcgatcgcg atgcattaat taagcggccg aggctcagag gcacacagga 1800
gtttctgggc tcaccctgcc cccttccaac ccctcagttc ccatcctcca gcagctgttt 1860
gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc tactcatgtc cctaaaatgg 1920
gcaaacattg caagcagcaa acagcaaaca cacagccctc cctgcctgct gaccttggag 1980
ctggggcaga ggtcagagac ctctctgggc ccatgccacc tccaacatcc actcgacccc 2040
ttggaatttc ggtggagagg agcagaggtt gtcctggcgt ggtttaggta gtgtgagagg 2100
ggtacccggg gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga 2160
gggccagcta agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg 2220
gacacaggac gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg 2280
aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag 2340
ccagtggact tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca 2400
ccagcagcct cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc 2460
cctgtctcct cagcttcagg caccaccact gacctgggac agtgaatgat ccccctgatc 2520
tgcggcctcg acggtatcga taagcttgat atcgaattct agtcgtcgac cactttcaca 2580
atctgctagc aaaggttgcc accatgcagc gcgtgaacat gattatggcc gagagccctg 2640
gcctgatcac catctgcctg ctgggctacc tgctgagcgc cgagtgtaca ggtttgtttc 2700
cttttttaaa atacattgag tatgcttgcc ttttagatat agaaatatct gatgctgtct 2760
tcttcactaa attttgatta catgatttga cagcaatatt gaagagtcta acagccagca 2820
cgcaggttgg taagtactgg ttctttgtta gctaggtttt cttcttcttc atttttaaaa 2880
ctaaatagat cgacaatgct tatgatgcat ttatgtttaa taaacactgt tcagttcatg 2940
atttggtcat gtaattcctg ttagaaaaca ttcatctcct tggtttaaaa aaattaaaag 3000
tgggaaaaca aagaaatagc agaatatagt gaaaaaaaat aaccacatta tttttgtttg 3060
gacttaccac tttgaaatca aaatgggaaa caaaagcaca aacaatggcc ttatttacac 3120
aaaaagtctg attttaagat atatgacatt tcaaggtttc agaagtatgt aatgaggtgt 3180
gtctctaatt ttttaaatta tatatcttca atttaaagtt ttagttaaaa cataaagatt 3240
aacctttcat tagcaagctg ttagttatca ccaaagcttt tcatggatta ggaaaaaatc 3300
attttgtctc tatgtcaaac atcttggagt tgatatttgg ggaaacacaa tactcagttg 3360
agttccctag gggagaaaag caagcttaag aattgacata aagagtagga agttagctaa 3420
tgcaacatat atcactttgt tttttcacaa ctacagtgac tttatgtatt tcccagagga 3480
aggcatacag ggaagaaatt atcccatttg gacaaacagc atgttctcac aggaagcatt 3540
tatcacactt acttgtcaac tttctagaat caaatctagt agctgacagt accaggatca 3600
ggggtgccaa ccctaagcac ccccagaaag ctgactggcc ctgtggttcc cactccagac 3660
atgatgtcag ctgtgaaatc gacgtcgctg gaccataatt aggcttctgt tcttcaggag 3720
acatttgttc aaagtcattt gggcaaccat attctgaaaa cagcccagcc agggtgatgg 3780
atcactttgc aaagatcctc aatgagctat tttcaagtga tgacaaagtg tgaagttaac 3840
cgctcatttg agaactttct ttttcatcca aagtaaattc aaatatgatt agaaatctga 3900
ccttttatta ctggaattct cttgactaaa agtaaaattg aattttaatt cctaaatctc 3960
catgtgtata cagtactgtg ggaacatcac agattttggc tccatgccct aaagagaaat 4020
tggctttcag attatttgga ttaaaaacaa agactttctt aagagatgta aaattttcat 4080
gatgttttct tttttgctaa aactaaagaa ttattctttt acatttcagt gttcctggac 4140
cacgagaacg ccaacaagat cctgaacaga cccaagagat acaacagcgg caagctggaa 4200
gagttcgtgc agggcaacct ggaacgcgag tgcatggaag agaagtgcag cttcgaagag 4260
gccagagagg tgttcgagaa caccgagaga accaccgagt tctggaagca gtacgtggac 4320
ggcgaccagt gcgagagcaa cccttgtctg aacggcggca gctgcaagga cgacatcaac 4380
agctacgagt gctggtgccc cttcggcttc gagggcaaga actgcgagct ggacgtgacc 4440
tgcaacatca agaacggcag atgcgagcag ttctgcaaga acagcgccga caacaaggtc 4500
gtgtgctcct gcaccgaggg ctacagactg gccgagaacc agaagtcctg cgagcccgct 4560
gtgcctttcc catgcggaag agtgtccgtg tcccagacca gcaagctgac cagagccgag 4620
acagtgttcc ccgacgtgga ctacgtgaac agcaccgagg ccgagacaat cctggacaac 4680
atcacccaga gcacccagtc cttcaacgac ttcaccagag tcgtgggcgg cgaggatgct 4740
aagcctggcc agttcccgtg gcaggtggtg ctgaacggaa aggtggacgc cttctgcggc 4800
ggctccatcg tgaacgagaa gtggatcgtg acagccgccc actgcgtgga aaccggcgtg 4860
aagatcacag tggtggccgg cgagcacaac atcgaggaaa ccgagcacac agagcagaaa 4920
agaaacgtga tcaggatcat cccccaccac aactacaacg ccgccatcaa caagtacaac 4980
cacgatatcg ccctgctgga actggacgag cccctggtgc tgaatagcta cgtgaccccc 5040
atctgtatcg ccgacaaaga gtacaccaac atctttctga agttcggcag cggctacgtg 5100
tccggctggg gcagagtgtt tcacaagggc tactccgctc tggtgctgca gtacctgaga 5160
gtgcctctgg tggacagagc cacctgtctg gaaagcacca agttcagaat ctacaacaac 5220
atgttctgcg ctggcttcca cgagggcggc agagactctt gtcagggcga ttctggcggc 5280
cctcacgtga cagaggtgga aggcaccagc tttctgaccg gcatcatcag ctggggcgag 5340
gaatgcgcca tgaaggggaa gtacggcatc tacaccaagg tgtccagata cgtgaactgg 5400
atcaaagaaa agaccaagct gacataatga aagatggatt tccaaggtta attcattgga 5460
attgaaaatt aacagccccc cccccccccc cctgcagatc tcgagccgaa ttcctgcagc 5520
ccgggggatc agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc 5580
ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg 5640
aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg 5700
acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta 5760
tggcttctga ggcggaaaga accagctggg gctcgagatc cactagacta gtgtacacgc 5820
gtgatatcag atctgttacg tagataagta gcatggcggg ttaatcatta actacaagga 5880
acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg 5940
gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc 6000
gcgcagctgc ctgcaggtcg actctagagg atccccgggt accgagctcg aattcactgg 6060
ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg 6120
cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt 6180
cccaacagtt gcgcagcctg aatggcgaat ggcgcctgat gcggtatttt ctccttacgc 6240
atctgtgcgg tatttcacac cgcatacgtc aaagcaacca tagtacgcgc cctgtagcgg 6300
cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc 6360
ttagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc 6420
cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc 6480
gaccccaaaa aacttgattt gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg 6540
gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact 6600
ggaacaacac tcaactctat ctcgggctat tcttttgatt tataagggat tttgccgatt 6660
tcggtctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa 6720
atattaacgt ttacaatttt atggtgcact ctcagtacaa tctgctctga tgccgcatag 6780
ttaagccagc cccgacaccc gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc 6840
ccggcatccg cttacagaca agctgtgacc gtctccggga gctgcatgtg tcagaggttt 6900
tcaccgtcat caccgaaacg cgcgagacga aagggcctcg tgatacgcct atttttatag 6960
gttaatgtca tgataataat ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg 7020
cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga 7080
caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat 7140
ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca 7200
gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc 7260
gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca 7320
atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg 7380
caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca 7440
gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata 7500
accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag 7560
ctaaccgctt ttttgcacaa catgg                                       7585

<210> 449
<211> 7585
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV-human FIX R338L mouse optimized vector

<400> 449
gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg 60
acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg 120
gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag 180
ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg 240
gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct 300
cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac 360
agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact 420
catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga 480
tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt 540
cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct 600
gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc 660
taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc 720
ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc 780
tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg 840
ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt 900
cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg 960
agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg 1020
gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt 1080
atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag 1140
gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt 1200
gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta 1260
ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt 1320
cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc 1380
cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca 1440
acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc 1500
cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg 1560
accatgatta cgccaagctt gcatgcctgc aggcagctgc gcgctcgctc gctcactgag 1620
gccgcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag 1680
agagggagtg gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtaaag 1740
atctgatatc atcgatcgcg atgcattaat taagcggccg aggctcagag gcacacagga 1800
gtttctgggc tcaccctgcc cccttccaac ccctcagttc ccatcctcca gcagctgttt 1860
gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc tactcatgtc cctaaaatgg 1920
gcaaacattg caagcagcaa acagcaaaca cacagccctc cctgcctgct gaccttggag 1980
ctggggcaga ggtcagagac ctctctgggc ccatgccacc tccaacatcc actcgacccc 2040
ttggaatttc ggtggagagg agcagaggtt gtcctggcgt ggtttaggta gtgtgagagg 2100
ggtacccggg gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga 2160
gggccagcta agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg 2220
gacacaggac gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg 2280
aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag 2340
ccagtggact tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca 2400
ccagcagcct cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc 2460
cctgtctcct cagcttcagg caccaccact gacctgggac agtgaatgat ccccctgatc 2520
tgcggcctcg acggtatcga taagcttgat atcgaattct agtcgtcgac cactttcaca 2580
atctgctagc aaaggttgcc accatgcagc gcgtgaacat gattatggcc gagagccctg 2640
gcctgatcac catctgcctg ctgggctacc tgctgagcgc cgagtgtaca ggtttgtttc 2700
cttttttaaa atacattgag tatgcttgcc ttttagatat agaaatatct gatgctgtct 2760
tcttcactaa attttgatta catgatttga cagcaatatt gaagagtcta acagccagca 2820
cgcaggttgg taagtactgg ttctttgtta gctaggtttt cttcttcttc atttttaaaa 2880
ctaaatagat cgacaatgct tatgatgcat ttatgtttaa taaacactgt tcagttcatg 2940
atttggtcat gtaattcctg ttagaaaaca ttcatctcct tggtttaaaa aaattaaaag 3000
tgggaaaaca aagaaatagc agaatatagt gaaaaaaaat aaccacatta tttttgtttg 3060
gacttaccac tttgaaatca aaatgggaaa caaaagcaca aacaatggcc ttatttacac 3120
aaaaagtctg attttaagat atatgacatt tcaaggtttc agaagtatgt aatgaggtgt 3180
gtctctaatt ttttaaatta tatatcttca atttaaagtt ttagttaaaa cataaagatt 3240
aacctttcat tagcaagctg ttagttatca ccaaagcttt tcatggatta ggaaaaaatc 3300
attttgtctc tatgtcaaac atcttggagt tgatatttgg ggaaacacaa tactcagttg 3360
agttccctag gggagaaaag caagcttaag aattgacata aagagtagga agttagctaa 3420
tgcaacatat atcactttgt tttttcacaa ctacagtgac tttatgtatt tcccagagga 3480
aggcatacag ggaagaaatt atcccatttg gacaaacagc atgttctcac aggaagcatt 3540
tatcacactt acttgtcaac tttctagaat caaatctagt agctgacagt accaggatca 3600
ggggtgccaa ccctaagcac ccccagaaag ctgactggcc ctgtggttcc cactccagac 3660
atgatgtcag ctgtgaaatc gacgtcgctg gaccataatt aggcttctgt tcttcaggag 3720
acatttgttc aaagtcattt gggcaaccat attctgaaaa cagcccagcc agggtgatgg 3780
atcactttgc aaagatcctc aatgagctat tttcaagtga tgacaaagtg tgaagttaac 3840
cgctcatttg agaactttct ttttcatcca aagtaaattc aaatatgatt agaaatctga 3900
ccttttatta ctggaattct cttgactaaa agtaaaattg aattttaatt cctaaatctc 3960
catgtgtata cagtactgtg ggaacatcac agattttggc tccatgccct aaagagaaat 4020
tggctttcag attatttgga ttaaaaacaa agactttctt aagagatgta aaattttcat 4080
gatgttttct tttttgctaa aactaaagaa ttattctttt acatttcagt gttcctggac 4140
cacgagaacg ccaacaagat cctgaacaga cccaagagat acaacagcgg caagctggaa 4200
gagttcgtgc agggcaacct ggaacgcgag tgcatggaag agaagtgcag cttcgaagag 4260
gccagagagg tgttcgagaa caccgagaga accaccgagt tctggaagca gtacgtggac 4320
ggcgaccagt gcgagagcaa cccttgtctg aacggcggca gctgcaagga cgacatcaac 4380
agctacgagt gctggtgccc cttcggcttc gagggcaaga actgcgagct ggacgtgacc 4440
tgcaacatca agaacggcag atgcgagcag ttctgcaaga acagcgccga caacaaggtc 4500
gtgtgctcct gcaccgaggg ctacagactg gccgagaacc agaagtcctg cgagcccgct 4560
gtgcctttcc catgcggaag agtgtccgtg tcccagacca gcaagctgac cagagccgag 4620
acagtgttcc ccgacgtgga ctacgtgaac agcaccgagg ccgagacaat cctggacaac 4680
atcacccaga gcacccagtc cttcaacgac ttcaccagag tcgtgggcgg cgaggatgct 4740
aagcctggcc agttcccgtg gcaggtggtg ctgaacggaa aggtggacgc cttctgcggc 4800
ggctccatcg tgaacgagaa gtggatcgtg acagccgccc actgcgtgga aaccggcgtg 4860
aagatcacag tggtggccgg cgagcacaac atcgaggaaa ccgagcacac agagcagaaa 4920
agaaacgtga tcaggatcat cccccaccac aactacaacg ccgccatcaa caagtacaac 4980
cacgatatcg ccctgctgga actggacgag cccctggtgc tgaatagcta cgtgaccccc 5040
atctgtatcg ccgacaaaga gtacaccaac atctttctga agttcggcag cggctacgtg 5100
tccggctggg gcagagtgtt tcacaagggc agatccgctc tggtgctgca gtacctgaga 5160
gtgcctctgg tggacagagc cacctgtctg ctgagcacca agttcaccat ctacaacaac 5220
atgttctgcg ctggcttcca cgagggcggc agagactctt gtcagggcga ttctggcggc 5280
cctcacgtga cagaggtgga aggcaccagc tttctgaccg gcatcatcag ctggggcgag 5340
gaatgcgcca tgaaggggaa gtacggcatc tacaccaagg tgtccagata cgtgaactgg 5400
atcaaagaaa agaccaagct gacataatga aagatggatt tccaaggtta attcattgga 5460
attgaaaatt aacagccccc cccccccccc cctgcagatc tcgagccgaa ttcctgcagc 5520
ccgggggatc agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc 5580
ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg 5640
aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg 5700
acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta 5760
tggcttctga ggcggaaaga accagctggg gctcgagatc cactagacta gtgtacacgc 5820
gtgatatcag atctgttacg tagataagta gcatggcggg ttaatcatta actacaagga 5880
acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg 5940
gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc 6000
gcgcagctgc ctgcaggtcg actctagagg atccccgggt accgagctcg aattcactgg 6060
ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg 6120
cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt 6180
cccaacagtt gcgcagcctg aatggcgaat ggcgcctgat gcggtatttt ctccttacgc 6240
atctgtgcgg tatttcacac cgcatacgtc aaagcaacca tagtacgcgc cctgtagcgg 6300
cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc 6360
ttagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc 6420
cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc 6480
gaccccaaaa aacttgattt gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg 6540
gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact 6600
ggaacaacac tcaactctat ctcgggctat tcttttgatt tataagggat tttgccgatt 6660
tcggtctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa 6720
atattaacgt ttacaatttt atggtgcact ctcagtacaa tctgctctga tgccgcatag 6780
ttaagccagc cccgacaccc gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc 6840
ccggcatccg cttacagaca agctgtgacc gtctccggga gctgcatgtg tcagaggttt 6900
tcaccgtcat caccgaaacg cgcgagacga aagggcctcg tgatacgcct atttttatag 6960
gttaatgtca tgataataat ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg 7020
cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga 7080
caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat 7140
ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca 7200
gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc 7260
gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca 7320
atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg 7380
caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca 7440
gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata 7500
accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag 7560
ctaaccgctt ttttgcacaa catgg                                       7585

<210> 450
<211> 7585
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV-human WT-FIX vector

<400> 450
gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg 60
acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg 120
gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag 180
ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg 240
gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct 300
cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac 360
agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact 420
catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga 480
tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt 540
cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct 600
gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc 660
taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc 720
ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc 780
tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg 840
ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt 900
cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg 960
agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg 1020
gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt 1080
atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag 1140
gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt 1200
gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta 1260
ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt 1320
cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc 1380
cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca 1440
acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc 1500
cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg 1560
accatgatta cgccaagctt gcatgcctgc aggcagctgc gcgctcgctc gctcactgag 1620
gccgcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag 1680
agagggagtg gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtaaag 1740
atctgatatc atcgatcgcg atgcattaat taagcggccg aggctcagag gcacacagga 1800
gtttctgggc tcaccctgcc cccttccaac ccctcagttc ccatcctcca gcagctgttt 1860
gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc tactcatgtc cctaaaatgg 1920
gcaaacattg caagcagcaa acagcaaaca cacagccctc cctgcctgct gaccttggag 1980
ctggggcaga ggtcagagac ctctctgggc ccatgccacc tccaacatcc actcgacccc 2040
ttggaatttc ggtggagagg agcagaggtt gtcctggcgt ggtttaggta gtgtgagagg 2100
ggtacccggg gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga 2160
gggccagcta agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg 2220
gacacaggac gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg 2280
aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag 2340
ccagtggact tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca 2400
ccagcagcct cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc 2460
cctgtctcct cagcttcagg caccaccact gacctgggac agtgaatgat ccccctgatc 2520
tgcggcctcg acggtatcga taagcttgat atcgaattct agtcgtcgac cactttcaca 2580
atctgctagc aaaggttgcc accatgcagc gcgtgaacat gatcatggca gaatcaccag 2640
gcctcatcac catctgcctt ttaggatatc tactcagtgc tgaatgtaca ggtttgtttc 2700
cttttttaaa atacattgag tatgcttgcc ttttagatat agaaatatct gatgctgtct 2760
tcttcactaa attttgatta catgatttga cagcaatatt gaagagtcta acagccagca 2820
cgcaggttgg taagtactgg ttctttgtta gctaggtttt cttcttcttc atttttaaaa 2880
ctaaatagat cgacaatgct tatgatgcat ttatgtttaa taaacactgt tcagttcatg 2940
atttggtcat gtaattcctg ttagaaaaca ttcatctcct tggtttaaaa aaattaaaag 3000
tgggaaaaca aagaaatagc agaatatagt gaaaaaaaat aaccacatta tttttgtttg 3060
gacttaccac tttgaaatca aaatgggaaa caaaagcaca aacaatggcc ttatttacac 3120
aaaaagtctg attttaagat atatgacatt tcaaggtttc agaagtatgt aatgaggtgt 3180
gtctctaatt ttttaaatta tatatcttca atttaaagtt ttagttaaaa cataaagatt 3240
aacctttcat tagcaagctg ttagttatca ccaaagcttt tcatggatta ggaaaaaatc 3300
attttgtctc tatgtcaaac atcttggagt tgatatttgg ggaaacacaa tactcagttg 3360
agttccctag gggagaaaag caagcttaag aattgacata aagagtagga agttagctaa 3420
tgcaacatat atcactttgt tttttcacaa ctacagtgac tttatgtatt tcccagagga 3480
aggcatacag ggaagaaatt atcccatttg gacaaacagc atgttctcac aggaagcatt 3540
tatcacactt acttgtcaac tttctagaat caaatctagt agctgacagt accaggatca 3600
ggggtgccaa ccctaagcac ccccagaaag ctgactggcc ctgtggttcc cactccagac 3660
atgatgtcag ctgtgaaatc gacgtcgctg gaccataatt aggcttctgt tcttcaggag 3720
acatttgttc aaagtcattt gggcaaccat attctgaaaa cagcccagcc agggtgatgg 3780
atcactttgc aaagatcctc aatgagctat tttcaagtga tgacaaagtg tgaagttaac 3840
cgctcatttg agaactttct ttttcatcca aagtaaattc aaatatgatt agaaatctga 3900
ccttttatta ctggaattct cttgactaaa agtaaaattg aattttaatt cctaaatctc 3960
catgtgtata cagtactgtg ggaacatcac agattttggc tccatgccct aaagagaaat 4020
tggctttcag attatttgga ttaaaaacaa agactttctt aagagatgta aaattttcat 4080
gatgttttct tttttgctaa aactaaagaa ttattctttt acatttcagt ttttcttgat 4140
catgaaaacg ccaacaaaat tctgaatcgg ccaaagaggt ataattcagg taaattggaa 4200
gagtttgttc aagggaacct tgagagagaa tgtatggaag aaaagtgtag ttttgaagaa 4260
gcacgagaag tttttgaaaa cactgaaaga acaactgaat tttggaagca gtatgttgat 4320
ggagatcagt gtgagtccaa tccatgttta aatggcggca gttgcaagga tgacattaat 4380
tcctatgaat gttggtgtcc ctttggattt gaaggaaaga actgtgaatt agatgtaaca 4440
tgtaacatta agaatggcag atgcgagcag ttttgtaaaa atagtgctga taacaaggtg 4500
gtttgctcct gtactgaggg atatcgactt gcagaaaacc agaagtcctg tgaaccagca 4560
gtgccatttc catgtggaag agtttctgtt tcacaaactt ctaagctcac ccgtgctgag 4620
actgtttttc ctgatgtgga ctatgtaaat tctactgaag ctgaaaccat tttggataac 4680
atcactcaaa gcacccaatc atttaatgac ttcactcggg ttgttggtgg agaagatgcc 4740
aaaccaggtc aattcccttg gcaggttgtt ttgaatggta aagttgatgc attctgtgga 4800
ggctctatcg ttaatgaaaa atggattgta actgctgccc actgtgttga aactggtgtt 4860
aaaattacag ttgtcgcagg tgaacataat attgaggaga cagaacatac agagcaaaag 4920
cgaaatgtga ttcgaattat tcctcaccac aactacaatg cagctattaa taagtacaac 4980
catgacattg cccttctgga actggacgaa cccttagtgc taaacagcta cgttacacct 5040
atttgcattg ctgacaagga atacacgaac atcttcctca aatttggatc tggctatgta 5100
agtggctggg gaagagtctt ccacaaaggg agatcagctt tagttcttca gtaccttaga 5160
gttccacttg ttgaccgagc cacatgtctt cgatctacaa agttcaccat ctataacaac 5220
atgttctgtg ctggcttcca tgaaggaggt agagattcat gtcaaggaga tagtggggga 5280
ccccatgtta ctgaagtgga agggaccagt ttcttaactg gaattattag ctggggtgaa 5340
gagtgtgcaa tgaaaggcaa atatggaata tataccaagg tatcccggta tgtcaactgg 5400
attaaggaaa aaacaaagct cacttaatga aagatggatt tccaaggtta attcattgga 5460
attgaaaatt aacagccccc cccccccccc cctgcagatc tcgagccgaa ttcctgcagc 5520
ccgggggatc agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc 5580
ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg 5640
aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg 5700
acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta 5760
tggcttctga ggcggaaaga accagctggg gctcgagatc cactagacta gtgtacacgc 5820
gtgatatcag atctgttacg tagataagta gcatggcggg ttaatcatta actacaagga 5880
acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg 5940
gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc 6000
gcgcagctgc ctgcaggtcg actctagagg atccccgggt accgagctcg aattcactgg 6060
ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg 6120
cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt 6180
cccaacagtt gcgcagcctg aatggcgaat ggcgcctgat gcggtatttt ctccttacgc 6240
atctgtgcgg tatttcacac cgcatacgtc aaagcaacca tagtacgcgc cctgtagcgg 6300
cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc 6360
ttagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc 6420
cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc 6480
gaccccaaaa aacttgattt gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg 6540
gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact 6600
ggaacaacac tcaactctat ctcgggctat tcttttgatt tataagggat tttgccgatt 6660
tcggtctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa 6720
atattaacgt ttacaatttt atggtgcact ctcagtacaa tctgctctga tgccgcatag 6780
ttaagccagc cccgacaccc gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc 6840
ccggcatccg cttacagaca agctgtgacc gtctccggga gctgcatgtg tcagaggttt 6900
tcaccgtcat caccgaaacg cgcgagacga aagggcctcg tgatacgcct atttttatag 6960
gttaatgtca tgataataat ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg 7020
cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga 7080
caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat 7140
ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca 7200
gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc 7260
gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca 7320
atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg 7380
caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca 7440
gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata 7500
accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag 7560
ctaaccgctt ttttgcacaa catgg                                       7585

<210> 451
<211> 7585
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV-human FIX R318Y/R338E/T343R vector

<400> 451
gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg 60
acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg 120
gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag 180
ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg 240
gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct 300
cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac 360
agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact 420
catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga 480
tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt 540
cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct 600
gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc 660
taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc 720
ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc 780
tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg 840
ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt 900
cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg 960
agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg 1020
gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt 1080
atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag 1140
gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt 1200
gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta 1260
ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt 1320
cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc 1380
cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca 1440
acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc 1500
cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg 1560
accatgatta cgccaagctt gcatgcctgc aggcagctgc gcgctcgctc gctcactgag 1620
gccgcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag 1680
agagggagtg gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtaaag 1740
atctgatatc atcgatcgcg atgcattaat taagcggccg aggctcagag gcacacagga 1800
gtttctgggc tcaccctgcc cccttccaac ccctcagttc ccatcctcca gcagctgttt 1860
gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc tactcatgtc cctaaaatgg 1920
gcaaacattg caagcagcaa acagcaaaca cacagccctc cctgcctgct gaccttggag 1980
ctggggcaga ggtcagagac ctctctgggc ccatgccacc tccaacatcc actcgacccc 2040
ttggaatttc ggtggagagg agcagaggtt gtcctggcgt ggtttaggta gtgtgagagg 2100
ggtacccggg gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga 2160
gggccagcta agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg 2220
gacacaggac gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg 2280
aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag 2340
ccagtggact tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca 2400
ccagcagcct cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc 2460
cctgtctcct cagcttcagg caccaccact gacctgggac agtgaatgat ccccctgatc 2520
tgcggcctcg acggtatcga taagcttgat atcgaattct agtcgtcgac cactttcaca 2580
atctgctagc aaaggttgcc accatgcagc gcgtgaacat gatcatggca gaatcaccag 2640
gcctcatcac catctgcctt ttaggatatc tactcagtgc tgaatgtaca ggtttgtttc 2700
cttttttaaa atacattgag tatgcttgcc ttttagatat agaaatatct gatgctgtct 2760
tcttcactaa attttgatta catgatttga cagcaatatt gaagagtcta acagccagca 2820
cgcaggttgg taagtactgg ttctttgtta gctaggtttt cttcttcttc atttttaaaa 2880
ctaaatagat cgacaatgct tatgatgcat ttatgtttaa taaacactgt tcagttcatg 2940
atttggtcat gtaattcctg ttagaaaaca ttcatctcct tggtttaaaa aaattaaaag 3000
tgggaaaaca aagaaatagc agaatatagt gaaaaaaaat aaccacatta tttttgtttg 3060
gacttaccac tttgaaatca aaatgggaaa caaaagcaca aacaatggcc ttatttacac 3120
aaaaagtctg attttaagat atatgacatt tcaaggtttc agaagtatgt aatgaggtgt 3180
gtctctaatt ttttaaatta tatatcttca atttaaagtt ttagttaaaa cataaagatt 3240
aacctttcat tagcaagctg ttagttatca ccaaagcttt tcatggatta ggaaaaaatc 3300
attttgtctc tatgtcaaac atcttggagt tgatatttgg ggaaacacaa tactcagttg 3360
agttccctag gggagaaaag caagcttaag aattgacata aagagtagga agttagctaa 3420
tgcaacatat atcactttgt tttttcacaa ctacagtgac tttatgtatt tcccagagga 3480
aggcatacag ggaagaaatt atcccatttg gacaaacagc atgttctcac aggaagcatt 3540
tatcacactt acttgtcaac tttctagaat caaatctagt agctgacagt accaggatca 3600
ggggtgccaa ccctaagcac ccccagaaag ctgactggcc ctgtggttcc cactccagac 3660
atgatgtcag ctgtgaaatc gacgtcgctg gaccataatt aggcttctgt tcttcaggag 3720
acatttgttc aaagtcattt gggcaaccat attctgaaaa cagcccagcc agggtgatgg 3780
atcactttgc aaagatcctc aatgagctat tttcaagtga tgacaaagtg tgaagttaac 3840
cgctcatttg agaactttct ttttcatcca aagtaaattc aaatatgatt agaaatctga 3900
ccttttatta ctggaattct cttgactaaa agtaaaattg aattttaatt cctaaatctc 3960
catgtgtata cagtactgtg ggaacatcac agattttggc tccatgccct aaagagaaat 4020
tggctttcag attatttgga ttaaaaacaa agactttctt aagagatgta aaattttcat 4080
gatgttttct tttttgctaa aactaaagaa ttattctttt acatttcagt ttttcttgat 4140
catgaaaacg ccaacaaaat tctgaatcgg ccaaagaggt ataattcagg taaattggaa 4200
gagtttgttc aagggaacct tgagagagaa tgtatggaag aaaagtgtag ttttgaagaa 4260
gcacgagaag tttttgaaaa cactgaaaga acaactgaat tttggaagca gtatgttgat 4320
ggagatcagt gtgagtccaa tccatgttta aatggcggca gttgcaagga tgacattaat 4380
tcctatgaat gttggtgtcc ctttggattt gaaggaaaga actgtgaatt agatgtaaca 4440
tgtaacatta agaatggcag atgcgagcag ttttgtaaaa atagtgctga taacaaggtg 4500
gtttgctcct gtactgaggg atatcgactt gcagaaaacc agaagtcctg tgaaccagca 4560
gtgccatttc catgtggaag agtttctgtt tcacaaactt ctaagctcac ccgtgctgag 4620
actgtttttc ctgatgtgga ctatgtaaat tctactgaag ctgaaaccat tttggataac 4680
atcactcaaa gcacccaatc atttaatgac ttcactcggg ttgttggtgg agaagatgcc 4740
aaaccaggtc aattcccttg gcaggttgtt ttgaatggta aagttgatgc attctgtgga 4800
ggctctatcg ttaatgaaaa atggattgta actgctgccc actgtgttga aactggtgtt 4860
aaaattacag ttgtcgcagg tgaacataat attgaggaga cagaacatac agagcaaaag 4920
cgaaatgtga ttcgaattat tcctcaccac aactacaatg cagctattaa taagtacaac 4980
catgacattg cccttctgga actggacgaa cccttagtgc taaacagcta cgttacacct 5040
atttgcattg ctgacaagga atacacgaac atcttcctca aatttggatc tggctatgta 5100
agtggctggg gaagagtctt ccacaaaggg tactcagctt tagttcttca gtaccttaga 5160
gttccacttg ttgaccgagc cacatgtctt gaatctacaa agttcaggat ctataacaac 5220
atgttctgtg ctggcttcca tgaaggaggt agagattcat gtcaaggaga tagtggggga 5280
ccccatgtta ctgaagtgga agggaccagt ttcttaactg gaattattag ctggggtgaa 5340
gagtgtgcaa tgaaaggcaa atatggaata tataccaagg tatcccggta tgtcaactgg 5400
attaaggaaa aaacaaagct cacttaatga aagatggatt tccaaggtta attcattgga 5460
attgaaaatt aacagccccc cccccccccc cctgcagatc tcgagccgaa ttcctgcagc 5520
ccgggggatc agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc 5580
ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg 5640
aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg 5700
acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta 5760
tggcttctga ggcggaaaga accagctggg gctcgagatc cactagacta gtgtacacgc 5820
gtgatatcag atctgttacg tagataagta gcatggcggg ttaatcatta actacaagga 5880
acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg 5940
gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc 6000
gcgcagctgc ctgcaggtcg actctagagg atccccgggt accgagctcg aattcactgg 6060
ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg 6120
cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt 6180
cccaacagtt gcgcagcctg aatggcgaat ggcgcctgat gcggtatttt ctccttacgc 6240
atctgtgcgg tatttcacac cgcatacgtc aaagcaacca tagtacgcgc cctgtagcgg 6300
cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc 6360
ttagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc 6420
cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc 6480
gaccccaaaa aacttgattt gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg 6540
gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact 6600
ggaacaacac tcaactctat ctcgggctat tcttttgatt tataagggat tttgccgatt 6660
tcggtctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa 6720
atattaacgt ttacaatttt atggtgcact ctcagtacaa tctgctctga tgccgcatag 6780
ttaagccagc cccgacaccc gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc 6840
ccggcatccg cttacagaca agctgtgacc gtctccggga gctgcatgtg tcagaggttt 6900
tcaccgtcat caccgaaacg cgcgagacga aagggcctcg tgatacgcct atttttatag 6960
gttaatgtca tgataataat ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg 7020
cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga 7080
caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat 7140
ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca 7200
gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc 7260
gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca 7320
atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg 7380
caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca 7440
gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata 7500
accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag 7560
ctaaccgctt ttttgcacaa catgg                                       7585

<210> 452
<211> 7585
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV-human FIX R338L vector

<400> 452
gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg 60
acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg 120
gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag 180
ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg 240
gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct 300
cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac 360
agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact 420
catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga 480
tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt 540
cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct 600
gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc 660
taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc 720
ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc 780
tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg 840
ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt 900
cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg 960
agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg 1020
gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt 1080
atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag 1140
gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt 1200
gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta 1260
ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt 1320
cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc 1380
cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca 1440
acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc 1500
cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg 1560
accatgatta cgccaagctt gcatgcctgc aggcagctgc gcgctcgctc gctcactgag 1620
gccgcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag 1680
agagggagtg gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtaaag 1740
atctgatatc atcgatcgcg atgcattaat taagcggccg aggctcagag gcacacagga 1800
gtttctgggc tcaccctgcc cccttccaac ccctcagttc ccatcctcca gcagctgttt 1860
gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc tactcatgtc cctaaaatgg 1920
gcaaacattg caagcagcaa acagcaaaca cacagccctc cctgcctgct gaccttggag 1980
ctggggcaga ggtcagagac ctctctgggc ccatgccacc tccaacatcc actcgacccc 2040
ttggaatttc ggtggagagg agcagaggtt gtcctggcgt ggtttaggta gtgtgagagg 2100
ggtacccggg gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga 2160
gggccagcta agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg 2220
gacacaggac gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg 2280
aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag 2340
ccagtggact tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca 2400
ccagcagcct cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc 2460
cctgtctcct cagcttcagg caccaccact gacctgggac agtgaatgat ccccctgatc 2520
tgcggcctcg acggtatcga taagcttgat atcgaattct agtcgtcgac cactttcaca 2580
atctgctagc aaaggttgcc accatgcagc gcgtgaacat gatcatggca gaatcaccag 2640
gcctcatcac catctgcctt ttaggatatc tactcagtgc tgaatgtaca ggtttgtttc 2700
cttttttaaa atacattgag tatgcttgcc ttttagatat agaaatatct gatgctgtct 2760
tcttcactaa attttgatta catgatttga cagcaatatt gaagagtcta acagccagca 2820
cgcaggttgg taagtactgg ttctttgtta gctaggtttt cttcttcttc atttttaaaa 2880
ctaaatagat cgacaatgct tatgatgcat ttatgtttaa taaacactgt tcagttcatg 2940
atttggtcat gtaattcctg ttagaaaaca ttcatctcct tggtttaaaa aaattaaaag 3000
tgggaaaaca aagaaatagc agaatatagt gaaaaaaaat aaccacatta tttttgtttg 3060
gacttaccac tttgaaatca aaatgggaaa caaaagcaca aacaatggcc ttatttacac 3120
aaaaagtctg attttaagat atatgacatt tcaaggtttc agaagtatgt aatgaggtgt 3180
gtctctaatt ttttaaatta tatatcttca atttaaagtt ttagttaaaa cataaagatt 3240
aacctttcat tagcaagctg ttagttatca ccaaagcttt tcatggatta ggaaaaaatc 3300
attttgtctc tatgtcaaac atcttggagt tgatatttgg ggaaacacaa tactcagttg 3360
agttccctag gggagaaaag caagcttaag aattgacata aagagtagga agttagctaa 3420
tgcaacatat atcactttgt tttttcacaa ctacagtgac tttatgtatt tcccagagga 3480
aggcatacag ggaagaaatt atcccatttg gacaaacagc atgttctcac aggaagcatt 3540
tatcacactt acttgtcaac tttctagaat caaatctagt agctgacagt accaggatca 3600
ggggtgccaa ccctaagcac ccccagaaag ctgactggcc ctgtggttcc cactccagac 3660
atgatgtcag ctgtgaaatc gacgtcgctg gaccataatt aggcttctgt tcttcaggag 3720
acatttgttc aaagtcattt gggcaaccat attctgaaaa cagcccagcc agggtgatgg 3780
atcactttgc aaagatcctc aatgagctat tttcaagtga tgacaaagtg tgaagttaac 3840
cgctcatttg agaactttct ttttcatcca aagtaaattc aaatatgatt agaaatctga 3900
ccttttatta ctggaattct cttgactaaa agtaaaattg aattttaatt cctaaatctc 3960
catgtgtata cagtactgtg ggaacatcac agattttggc tccatgccct aaagagaaat 4020
tggctttcag attatttgga ttaaaaacaa agactttctt aagagatgta aaattttcat 4080
gatgttttct tttttgctaa aactaaagaa ttattctttt acatttcagt ttttcttgat 4140
catgaaaacg ccaacaaaat tctgaatcgg ccaaagaggt ataattcagg taaattggaa 4200
gagtttgttc aagggaacct tgagagagaa tgtatggaag aaaagtgtag ttttgaagaa 4260
gcacgagaag tttttgaaaa cactgaaaga acaactgaat tttggaagca gtatgttgat 4320
ggagatcagt gtgagtccaa tccatgttta aatggcggca gttgcaagga tgacattaat 4380
tcctatgaat gttggtgtcc ctttggattt gaaggaaaga actgtgaatt agatgtaaca 4440
tgtaacatta agaatggcag atgcgagcag ttttgtaaaa atagtgctga taacaaggtg 4500
gtttgctcct gtactgaggg atatcgactt gcagaaaacc agaagtcctg tgaaccagca 4560
gtgccatttc catgtggaag agtttctgtt tcacaaactt ctaagctcac ccgtgctgag 4620
actgtttttc ctgatgtgga ctatgtaaat tctactgaag ctgaaaccat tttggataac 4680
atcactcaaa gcacccaatc atttaatgac ttcactcggg ttgttggtgg agaagatgcc 4740
aaaccaggtc aattcccttg gcaggttgtt ttgaatggta aagttgatgc attctgtgga 4800
ggctctatcg ttaatgaaaa atggattgta actgctgccc actgtgttga aactggtgtt 4860
aaaattacag ttgtcgcagg tgaacataat attgaggaga cagaacatac agagcaaaag 4920
cgaaatgtga ttcgaattat tcctcaccac aactacaatg cagctattaa taagtacaac 4980
catgacattg cccttctgga actggacgaa cccttagtgc taaacagcta cgttacacct 5040
atttgcattg ctgacaagga atacacgaac atcttcctca aatttggatc tggctatgta 5100
agtggctggg gaagagtctt ccacaaaggg agatcagctt tagttcttca gtaccttaga 5160
gttccacttg ttgaccgagc cacatgtctt ctgtctacaa agttcaccat ctataacaac 5220
atgttctgtg ctggcttcca tgaaggaggt agagattcat gtcaaggaga tagtggggga 5280
ccccatgtta ctgaagtgga agggaccagt ttcttaactg gaattattag ctggggtgaa 5340
gagtgtgcaa tgaaaggcaa atatggaata tataccaagg tatcccggta tgtcaactgg 5400
attaaggaaa aaacaaagct cacttaatga aagatggatt tccaaggtta attcattgga 5460
attgaaaatt aacagccccc cccccccccc cctgcagatc tcgagccgaa ttcctgcagc 5520
ccgggggatc agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc 5580
ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg 5640
aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg 5700
acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta 5760
tggcttctga ggcggaaaga accagctggg gctcgagatc cactagacta gtgtacacgc 5820
gtgatatcag atctgttacg tagataagta gcatggcggg ttaatcatta actacaagga 5880
acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg 5940
gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc 6000
gcgcagctgc ctgcaggtcg actctagagg atccccgggt accgagctcg aattcactgg 6060
ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg 6120
cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt 6180
cccaacagtt gcgcagcctg aatggcgaat ggcgcctgat gcggtatttt ctccttacgc 6240
atctgtgcgg tatttcacac cgcatacgtc aaagcaacca tagtacgcgc cctgtagcgg 6300
cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc 6360
ttagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc 6420
cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc 6480
gaccccaaaa aacttgattt gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg 6540
gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact 6600
ggaacaacac tcaactctat ctcgggctat tcttttgatt tataagggat tttgccgatt 6660
tcggtctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa 6720
atattaacgt ttacaatttt atggtgcact ctcagtacaa tctgctctga tgccgcatag 6780
ttaagccagc cccgacaccc gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc 6840
ccggcatccg cttacagaca agctgtgacc gtctccggga gctgcatgtg tcagaggttt 6900
tcaccgtcat caccgaaacg cgcgagacga aagggcctcg tgatacgcct atttttatag 6960
gttaatgtca tgataataat ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg 7020
cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga 7080
caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat 7140
ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca 7200
gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc 7260
gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca 7320
atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg 7380
caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca 7440
gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata 7500
accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag 7560
ctaaccgctt ttttgcacaa catgg                                       7585

<210> 453
<211> 7585
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV-human FIX T148A vector

<400> 453
gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg 60
acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg 120
gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag 180
ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg 240
gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct 300
cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac 360
agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact 420
catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga 480
tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt 540
cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct 600
gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc 660
taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc 720
ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc 780
tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg 840
ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt 900
cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg 960
agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg 1020
gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt 1080
atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag 1140
gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt 1200
gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta 1260
ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt 1320
cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc 1380
cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca 1440
acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc 1500
cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg 1560
accatgatta cgccaagctt gcatgcctgc aggcagctgc gcgctcgctc gctcactgag 1620
gccgcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag 1680
agagggagtg gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtaaag 1740
atctgatatc atcgatcgcg atgcattaat taagcggccg aggctcagag gcacacagga 1800
gtttctgggc tcaccctgcc cccttccaac ccctcagttc ccatcctcca gcagctgttt 1860
gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc tactcatgtc cctaaaatgg 1920
gcaaacattg caagcagcaa acagcaaaca cacagccctc cctgcctgct gaccttggag 1980
ctggggcaga ggtcagagac ctctctgggc ccatgccacc tccaacatcc actcgacccc 2040
ttggaatttc ggtggagagg agcagaggtt gtcctggcgt ggtttaggta gtgtgagagg 2100
ggtacccggg gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga 2160
gggccagcta agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg 2220
gacacaggac gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg 2280
aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag 2340
ccagtggact tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca 2400
ccagcagcct cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc 2460
cctgtctcct cagcttcagg caccaccact gacctgggac agtgaatgat ccccctgatc 2520
tgcggcctcg acggtatcga taagcttgat atcgaattct agtcgtcgac cactttcaca 2580
atctgctagc aaaggttgcc accatgcagc gcgtgaacat gatcatggca gaatcaccag 2640
gcctcatcac catctgcctt ttaggatatc tactcagtgc tgaatgtaca ggtttgtttc 2700
cttttttaaa atacattgag tatgcttgcc ttttagatat agaaatatct gatgctgtct 2760
tcttcactaa attttgatta catgatttga cagcaatatt gaagagtcta acagccagca 2820
cgcaggttgg taagtactgg ttctttgtta gctaggtttt cttcttcttc atttttaaaa 2880
ctaaatagat cgacaatgct tatgatgcat ttatgtttaa taaacactgt tcagttcatg 2940
atttggtcat gtaattcctg ttagaaaaca ttcatctcct tggtttaaaa aaattaaaag 3000
tgggaaaaca aagaaatagc agaatatagt gaaaaaaaat aaccacatta tttttgtttg 3060
gacttaccac tttgaaatca aaatgggaaa caaaagcaca aacaatggcc ttatttacac 3120
aaaaagtctg attttaagat atatgacatt tcaaggtttc agaagtatgt aatgaggtgt 3180
gtctctaatt ttttaaatta tatatcttca atttaaagtt ttagttaaaa cataaagatt 3240
aacctttcat tagcaagctg ttagttatca ccaaagcttt tcatggatta ggaaaaaatc 3300
attttgtctc tatgtcaaac atcttggagt tgatatttgg ggaaacacaa tactcagttg 3360
agttccctag gggagaaaag caagcttaag aattgacata aagagtagga agttagctaa 3420
tgcaacatat atcactttgt tttttcacaa ctacagtgac tttatgtatt tcccagagga 3480
aggcatacag ggaagaaatt atcccatttg gacaaacagc atgttctcac aggaagcatt 3540
tatcacactt acttgtcaac tttctagaat caaatctagt agctgacagt accaggatca 3600
ggggtgccaa ccctaagcac ccccagaaag ctgactggcc ctgtggttcc cactccagac 3660
atgatgtcag ctgtgaaatc gacgtcgctg gaccataatt aggcttctgt tcttcaggag 3720
acatttgttc aaagtcattt gggcaaccat attctgaaaa cagcccagcc agggtgatgg 3780
atcactttgc aaagatcctc aatgagctat tttcaagtga tgacaaagtg tgaagttaac 3840
cgctcatttg agaactttct ttttcatcca aagtaaattc aaatatgatt agaaatctga 3900
ccttttatta ctggaattct cttgactaaa agtaaaattg aattttaatt cctaaatctc 3960
catgtgtata cagtactgtg ggaacatcac agattttggc tccatgccct aaagagaaat 4020
tggctttcag attatttgga ttaaaaacaa agactttctt aagagatgta aaattttcat 4080
gatgttttct tttttgctaa aactaaagaa ttattctttt acatttcagt ttttcttgat 4140
catgaaaacg ccaacaaaat tctgaatcgg ccaaagaggt ataattcagg taaattggaa 4200
gagtttgttc aagggaacct tgagagagaa tgtatggaag aaaagtgtag ttttgaagaa 4260
gcacgagaag tttttgaaaa cactgaaaga acaactgaat tttggaagca gtatgttgat 4320
ggagatcagt gtgagtccaa tccatgttta aatggcggca gttgcaagga tgacattaat 4380
tcctatgaat gttggtgtcc ctttggattt gaaggaaaga actgtgaatt agatgtaaca 4440
tgtaacatta agaatggcag atgcgagcag ttttgtaaaa atagtgctga taacaaggtg 4500
gtttgctcct gtactgaggg atatcgactt gcagaaaacc agaagtcctg tgaaccagca 4560
gtgccatttc catgtggaag agtttctgtt tcacaaactt ctaagctcac ccgtgctgag 4620
gctgtttttc ctgatgtgga ctatgtaaat tctactgaag ctgaaaccat tttggataac 4680
atcactcaaa gcacccaatc atttaatgac ttcactcggg ttgttggtgg agaagatgcc 4740
aaaccaggtc aattcccttg gcaggttgtt ttgaatggta aagttgatgc attctgtgga 4800
ggctctatcg ttaatgaaaa atggattgta actgctgccc actgtgttga aactggtgtt 4860
aaaattacag ttgtcgcagg tgaacataat attgaggaga cagaacatac agagcaaaag 4920
cgaaatgtga ttcgaattat tcctcaccac aactacaatg cagctattaa taagtacaac 4980
catgacattg cccttctgga actggacgaa cccttagtgc taaacagcta cgttacacct 5040
atttgcattg ctgacaagga atacacgaac atcttcctca aatttggatc tggctatgta 5100
agtggctggg gaagagtctt ccacaaaggg agatcagctt tagttcttca gtaccttaga 5160
gttccacttg ttgaccgagc cacatgtctt cgatctacaa agttcaccat ctataacaac 5220
atgttctgtg ctggcttcca tgaaggaggt agagattcat gtcaaggaga tagtggggga 5280
ccccatgtta ctgaagtgga agggaccagt ttcttaactg gaattattag ctggggtgaa 5340
gagtgtgcaa tgaaaggcaa atatggaata tataccaagg tatcccggta tgtcaactgg 5400
attaaggaaa aaacaaagct cacttaatga aagatggatt tccaaggtta attcattgga 5460
attgaaaatt aacagccccc cccccccccc cctgcagatc tcgagccgaa ttcctgcagc 5520
ccgggggatc agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc 5580
ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg 5640
aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg 5700
acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta 5760
tggcttctga ggcggaaaga accagctggg gctcgagatc cactagacta gtgtacacgc 5820
gtgatatcag atctgttacg tagataagta gcatggcggg ttaatcatta actacaagga 5880
acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg 5940
gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc 6000
gcgcagctgc ctgcaggtcg actctagagg atccccgggt accgagctcg aattcactgg 6060
ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg 6120
cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt 6180
cccaacagtt gcgcagcctg aatggcgaat ggcgcctgat gcggtatttt ctccttacgc 6240
atctgtgcgg tatttcacac cgcatacgtc aaagcaacca tagtacgcgc cctgtagcgg 6300
cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc 6360
ttagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc 6420
cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc 6480
gaccccaaaa aacttgattt gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg 6540
gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact 6600
ggaacaacac tcaactctat ctcgggctat tcttttgatt tataagggat tttgccgatt 6660
tcggtctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa 6720
atattaacgt ttacaatttt atggtgcact ctcagtacaa tctgctctga tgccgcatag 6780
ttaagccagc cccgacaccc gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc 6840
ccggcatccg cttacagaca agctgtgacc gtctccggga gctgcatgtg tcagaggttt 6900
tcaccgtcat caccgaaacg cgcgagacga aagggcctcg tgatacgcct atttttatag 6960
gttaatgtca tgataataat ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg 7020
cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga 7080
caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat 7140
ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca 7200
gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc 7260
gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca 7320
atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg 7380
caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca 7440
gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata 7500
accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag 7560
ctaaccgctt ttttgcacaa catgg                                       7585

<210> 454
<211> 7585
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV-human FIX T148A/R318Y/R338E/T343R vector

<400> 454
gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg 60
acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg 120
gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag 180
ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg 240
gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct 300
cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac 360
agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact 420
catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga 480
tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt 540
cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct 600
gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc 660
taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc 720
ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc 780
tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg 840
ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt 900
cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg 960
agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg 1020
gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt 1080
atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag 1140
gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt 1200
gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta 1260
ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt 1320
cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc 1380
cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca 1440
acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc 1500
cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg 1560
accatgatta cgccaagctt gcatgcctgc aggcagctgc gcgctcgctc gctcactgag 1620
gccgcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag 1680
agagggagtg gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtaaag 1740
atctgatatc atcgatcgcg atgcattaat taagcggccg aggctcagag gcacacagga 1800
gtttctgggc tcaccctgcc cccttccaac ccctcagttc ccatcctcca gcagctgttt 1860
gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc tactcatgtc cctaaaatgg 1920
gcaaacattg caagcagcaa acagcaaaca cacagccctc cctgcctgct gaccttggag 1980
ctggggcaga ggtcagagac ctctctgggc ccatgccacc tccaacatcc actcgacccc 2040
ttggaatttc ggtggagagg agcagaggtt gtcctggcgt ggtttaggta gtgtgagagg 2100
ggtacccggg gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga 2160
gggccagcta agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg 2220
gacacaggac gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg 2280
aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag 2340
ccagtggact tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca 2400
ccagcagcct cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc 2460
cctgtctcct cagcttcagg caccaccact gacctgggac agtgaatgat ccccctgatc 2520
tgcggcctcg acggtatcga taagcttgat atcgaattct agtcgtcgac cactttcaca 2580
atctgctagc aaaggttgcc accatgcagc gcgtgaacat gatcatggca gaatcaccag 2640
gcctcatcac catctgcctt ttaggatatc tactcagtgc tgaatgtaca ggtttgtttc 2700
cttttttaaa atacattgag tatgcttgcc ttttagatat agaaatatct gatgctgtct 2760
tcttcactaa attttgatta catgatttga cagcaatatt gaagagtcta acagccagca 2820
cgcaggttgg taagtactgg ttctttgtta gctaggtttt cttcttcttc atttttaaaa 2880
ctaaatagat cgacaatgct tatgatgcat ttatgtttaa taaacactgt tcagttcatg 2940
atttggtcat gtaattcctg ttagaaaaca ttcatctcct tggtttaaaa aaattaaaag 3000
tgggaaaaca aagaaatagc agaatatagt gaaaaaaaat aaccacatta tttttgtttg 3060
gacttaccac tttgaaatca aaatgggaaa caaaagcaca aacaatggcc ttatttacac 3120
aaaaagtctg attttaagat atatgacatt tcaaggtttc agaagtatgt aatgaggtgt 3180
gtctctaatt ttttaaatta tatatcttca atttaaagtt ttagttaaaa cataaagatt 3240
aacctttcat tagcaagctg ttagttatca ccaaagcttt tcatggatta ggaaaaaatc 3300
attttgtctc tatgtcaaac atcttggagt tgatatttgg ggaaacacaa tactcagttg 3360
agttccctag gggagaaaag caagcttaag aattgacata aagagtagga agttagctaa 3420
tgcaacatat atcactttgt tttttcacaa ctacagtgac tttatgtatt tcccagagga 3480
aggcatacag ggaagaaatt atcccatttg gacaaacagc atgttctcac aggaagcatt 3540
tatcacactt acttgtcaac tttctagaat caaatctagt agctgacagt accaggatca 3600
ggggtgccaa ccctaagcac ccccagaaag ctgactggcc ctgtggttcc cactccagac 3660
atgatgtcag ctgtgaaatc gacgtcgctg gaccataatt aggcttctgt tcttcaggag 3720
acatttgttc aaagtcattt gggcaaccat attctgaaaa cagcccagcc agggtgatgg 3780
atcactttgc aaagatcctc aatgagctat tttcaagtga tgacaaagtg tgaagttaac 3840
cgctcatttg agaactttct ttttcatcca aagtaaattc aaatatgatt agaaatctga 3900
ccttttatta ctggaattct cttgactaaa agtaaaattg aattttaatt cctaaatctc 3960
catgtgtata cagtactgtg ggaacatcac agattttggc tccatgccct aaagagaaat 4020
tggctttcag attatttgga ttaaaaacaa agactttctt aagagatgta aaattttcat 4080
gatgttttct tttttgctaa aactaaagaa ttattctttt acatttcagt ttttcttgat 4140
catgaaaacg ccaacaaaat tctgaatcgg ccaaagaggt ataattcagg taaattggaa 4200
gagtttgttc aagggaacct tgagagagaa tgtatggaag aaaagtgtag ttttgaagaa 4260
gcacgagaag tttttgaaaa cactgaaaga acaactgaat tttggaagca gtatgttgat 4320
ggagatcagt gtgagtccaa tccatgttta aatggcggca gttgcaagga tgacattaat 4380
tcctatgaat gttggtgtcc ctttggattt gaaggaaaga actgtgaatt agatgtaaca 4440
tgtaacatta agaatggcag atgcgagcag ttttgtaaaa atagtgctga taacaaggtg 4500
gtttgctcct gtactgaggg atatcgactt gcagaaaacc agaagtcctg tgaaccagca 4560
gtgccatttc catgtggaag agtttctgtt tcacaaactt ctaagctcac ccgtgctgag 4620
gctgtttttc ctgatgtgga ctatgtaaat tctactgaag ctgaaaccat tttggataac 4680
atcactcaaa gcacccaatc atttaatgac ttcactcggg ttgttggtgg agaagatgcc 4740
aaaccaggtc aattcccttg gcaggttgtt ttgaatggta aagttgatgc attctgtgga 4800
ggctctatcg ttaatgaaaa atggattgta actgctgccc actgtgttga aactggtgtt 4860
aaaattacag ttgtcgcagg tgaacataat attgaggaga cagaacatac agagcaaaag 4920
cgaaatgtga ttcgaattat tcctcaccac aactacaatg cagctattaa taagtacaac 4980
catgacattg cccttctgga actggacgaa cccttagtgc taaacagcta cgttacacct 5040
atttgcattg ctgacaagga atacacgaac atcttcctca aatttggatc tggctatgta 5100
agtggctggg gaagagtctt ccacaaaggg tactcagctt tagttcttca gtaccttaga 5160
gttccacttg ttgaccgagc cacatgtctt gaatctacaa agttcaggat ctataacaac 5220
atgttctgtg ctggcttcca tgaaggaggt agagattcat gtcaaggaga tagtggggga 5280
ccccatgtta ctgaagtgga agggaccagt ttcttaactg gaattattag ctggggtgaa 5340
gagtgtgcaa tgaaaggcaa atatggaata tataccaagg tatcccggta tgtcaactgg 5400
attaaggaaa aaacaaagct cacttaatga aagatggatt tccaaggtta attcattgga 5460
attgaaaatt aacagccccc cccccccccc cctgcagatc tcgagccgaa ttcctgcagc 5520
ccgggggatc agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc 5580
ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg 5640
aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg 5700
acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta 5760
tggcttctga ggcggaaaga accagctggg gctcgagatc cactagacta gtgtacacgc 5820
gtgatatcag atctgttacg tagataagta gcatggcggg ttaatcatta actacaagga 5880
acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg 5940
gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc 6000
gcgcagctgc ctgcaggtcg actctagagg atccccgggt accgagctcg aattcactgg 6060
ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg 6120
cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt 6180
cccaacagtt gcgcagcctg aatggcgaat ggcgcctgat gcggtatttt ctccttacgc 6240
atctgtgcgg tatttcacac cgcatacgtc aaagcaacca tagtacgcgc cctgtagcgg 6300
cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc 6360
ttagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc 6420
cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc 6480
gaccccaaaa aacttgattt gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg 6540
gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact 6600
ggaacaacac tcaactctat ctcgggctat tcttttgatt tataagggat tttgccgatt 6660
tcggtctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa 6720
atattaacgt ttacaatttt atggtgcact ctcagtacaa tctgctctga tgccgcatag 6780
ttaagccagc cccgacaccc gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc 6840
ccggcatccg cttacagaca agctgtgacc gtctccggga gctgcatgtg tcagaggttt 6900
tcaccgtcat caccgaaacg cgcgagacga aagggcctcg tgatacgcct atttttatag 6960
gttaatgtca tgataataat ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg 7020
cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga 7080
caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat 7140
ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca 7200
gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc 7260
gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca 7320
atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg 7380
caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca 7440
gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata 7500
accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag 7560
ctaaccgctt ttttgcacaa catgg                                       7585

<210> 455
<211> 7585
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV-human FIX T148A/R338L vector

<400> 455
gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg 60
acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg 120
gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag 180
ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg 240
gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct 300
cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac 360
agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact 420
catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga 480
tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt 540
cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct 600
gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc 660
taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc 720
ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc 780
tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg 840
ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt 900
cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg 960
agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg 1020
gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt 1080
atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag 1140
gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt 1200
gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta 1260
ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt 1320
cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc 1380
cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca 1440
acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc 1500
cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg 1560
accatgatta cgccaagctt gcatgcctgc aggcagctgc gcgctcgctc gctcactgag 1620
gccgcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag 1680
agagggagtg gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtaaag 1740
atctgatatc atcgatcgcg atgcattaat taagcggccg aggctcagag gcacacagga 1800
gtttctgggc tcaccctgcc cccttccaac ccctcagttc ccatcctcca gcagctgttt 1860
gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc tactcatgtc cctaaaatgg 1920
gcaaacattg caagcagcaa acagcaaaca cacagccctc cctgcctgct gaccttggag 1980
ctggggcaga ggtcagagac ctctctgggc ccatgccacc tccaacatcc actcgacccc 2040
ttggaatttc ggtggagagg agcagaggtt gtcctggcgt ggtttaggta gtgtgagagg 2100
ggtacccggg gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga 2160
gggccagcta agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg 2220
gacacaggac gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg 2280
aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag 2340
ccagtggact tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca 2400
ccagcagcct cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc 2460
cctgtctcct cagcttcagg caccaccact gacctgggac agtgaatgat ccccctgatc 2520
tgcggcctcg acggtatcga taagcttgat atcgaattct agtcgtcgac cactttcaca 2580
atctgctagc aaaggttgcc accatgcagc gcgtgaacat gatcatggca gaatcaccag 2640
gcctcatcac catctgcctt ttaggatatc tactcagtgc tgaatgtaca ggtttgtttc 2700
cttttttaaa atacattgag tatgcttgcc ttttagatat agaaatatct gatgctgtct 2760
tcttcactaa attttgatta catgatttga cagcaatatt gaagagtcta acagccagca 2820
cgcaggttgg taagtactgg ttctttgtta gctaggtttt cttcttcttc atttttaaaa 2880
ctaaatagat cgacaatgct tatgatgcat ttatgtttaa taaacactgt tcagttcatg 2940
atttggtcat gtaattcctg ttagaaaaca ttcatctcct tggtttaaaa aaattaaaag 3000
tgggaaaaca aagaaatagc agaatatagt gaaaaaaaat aaccacatta tttttgtttg 3060
gacttaccac tttgaaatca aaatgggaaa caaaagcaca aacaatggcc ttatttacac 3120
aaaaagtctg attttaagat atatgacatt tcaaggtttc agaagtatgt aatgaggtgt 3180
gtctctaatt ttttaaatta tatatcttca atttaaagtt ttagttaaaa cataaagatt 3240
aacctttcat tagcaagctg ttagttatca ccaaagcttt tcatggatta ggaaaaaatc 3300
attttgtctc tatgtcaaac atcttggagt tgatatttgg ggaaacacaa tactcagttg 3360
agttccctag gggagaaaag caagcttaag aattgacata aagagtagga agttagctaa 3420
tgcaacatat atcactttgt tttttcacaa ctacagtgac tttatgtatt tcccagagga 3480
aggcatacag ggaagaaatt atcccatttg gacaaacagc atgttctcac aggaagcatt 3540
tatcacactt acttgtcaac tttctagaat caaatctagt agctgacagt accaggatca 3600
ggggtgccaa ccctaagcac ccccagaaag ctgactggcc ctgtggttcc cactccagac 3660
atgatgtcag ctgtgaaatc gacgtcgctg gaccataatt aggcttctgt tcttcaggag 3720
acatttgttc aaagtcattt gggcaaccat attctgaaaa cagcccagcc agggtgatgg 3780
atcactttgc aaagatcctc aatgagctat tttcaagtga tgacaaagtg tgaagttaac 3840
cgctcatttg agaactttct ttttcatcca aagtaaattc aaatatgatt agaaatctga 3900
ccttttatta ctggaattct cttgactaaa agtaaaattg aattttaatt cctaaatctc 3960
catgtgtata cagtactgtg ggaacatcac agattttggc tccatgccct aaagagaaat 4020
tggctttcag attatttgga ttaaaaacaa agactttctt aagagatgta aaattttcat 4080
gatgttttct tttttgctaa aactaaagaa ttattctttt acatttcagt ttttcttgat 4140
catgaaaacg ccaacaaaat tctgaatcgg ccaaagaggt ataattcagg taaattggaa 4200
gagtttgttc aagggaacct tgagagagaa tgtatggaag aaaagtgtag ttttgaagaa 4260
gcacgagaag tttttgaaaa cactgaaaga acaactgaat tttggaagca gtatgttgat 4320
ggagatcagt gtgagtccaa tccatgttta aatggcggca gttgcaagga tgacattaat 4380
tcctatgaat gttggtgtcc ctttggattt gaaggaaaga actgtgaatt agatgtaaca 4440
tgtaacatta agaatggcag atgcgagcag ttttgtaaaa atagtgctga taacaaggtg 4500
gtttgctcct gtactgaggg atatcgactt gcagaaaacc agaagtcctg tgaaccagca 4560
gtgccatttc catgtggaag agtttctgtt tcacaaactt ctaagctcac ccgtgctgag 4620
gctgtttttc ctgatgtgga ctatgtaaat tctactgaag ctgaaaccat tttggataac 4680
atcactcaaa gcacccaatc atttaatgac ttcactcggg ttgttggtgg agaagatgcc 4740
aaaccaggtc aattcccttg gcaggttgtt ttgaatggta aagttgatgc attctgtgga 4800
ggctctatcg ttaatgaaaa atggattgta actgctgccc actgtgttga aactggtgtt 4860
aaaattacag ttgtcgcagg tgaacataat attgaggaga cagaacatac agagcaaaag 4920
cgaaatgtga ttcgaattat tcctcaccac aactacaatg cagctattaa taagtacaac 4980
catgacattg cccttctgga actggacgaa cccttagtgc taaacagcta cgttacacct 5040
atttgcattg ctgacaagga atacacgaac atcttcctca aatttggatc tggctatgta 5100
agtggctggg gaagagtctt ccacaaaggg agatcagctt tagttcttca gtaccttaga 5160
gttccacttg ttgaccgagc cacatgtctt ctgtctacaa agttcaccat ctataacaac 5220
atgttctgtg ctggcttcca tgaaggaggt agagattcat gtcaaggaga tagtggggga 5280
ccccatgtta ctgaagtgga agggaccagt ttcttaactg gaattattag ctggggtgaa 5340
gagtgtgcaa tgaaaggcaa atatggaata tataccaagg tatcccggta tgtcaactgg 5400
attaaggaaa aaacaaagct cacttaatga aagatggatt tccaaggtta attcattgga 5460
attgaaaatt aacagccccc cccccccccc cctgcagatc tcgagccgaa ttcctgcagc 5520
ccgggggatc agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc 5580
ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg 5640
aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg 5700
acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta 5760
tggcttctga ggcggaaaga accagctggg gctcgagatc cactagacta gtgtacacgc 5820
gtgatatcag atctgttacg tagataagta gcatggcggg ttaatcatta actacaagga 5880
acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg 5940
gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc 6000
gcgcagctgc ctgcaggtcg actctagagg atccccgggt accgagctcg aattcactgg 6060
ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg 6120
cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt 6180
cccaacagtt gcgcagcctg aatggcgaat ggcgcctgat gcggtatttt ctccttacgc 6240
atctgtgcgg tatttcacac cgcatacgtc aaagcaacca tagtacgcgc cctgtagcgg 6300
cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc 6360
ttagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc 6420
cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc 6480
gaccccaaaa aacttgattt gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg 6540
gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact 6600
ggaacaacac tcaactctat ctcgggctat tcttttgatt tataagggat tttgccgatt 6660
tcggtctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa 6720
atattaacgt ttacaatttt atggtgcact ctcagtacaa tctgctctga tgccgcatag 6780
ttaagccagc cccgacaccc gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc 6840
ccggcatccg cttacagaca agctgtgacc gtctccggga gctgcatgtg tcagaggttt 6900
tcaccgtcat caccgaaacg cgcgagacga aagggcctcg tgatacgcct atttttatag 6960
gttaatgtca tgataataat ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg 7020
cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga 7080
caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat 7140
ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca 7200
gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc 7260
gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca 7320
atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg 7380
caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca 7440
gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata 7500
accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag 7560
ctaaccgctt ttttgcacaa catgg                                       7585

<210> 456
<211> 4410
<212> DNA
<213> Artificial Sequence

<220> 
<223> ITR-ApoE/C1-antitrypsin promoter-FIXss-Pro-mini
      Intron-human WTFIX mouse optimized-bGHpolyA-ITR

<220> 
<221> repeat_region  
<222> (1)...(119)
<223> ITR

<220> 
<221> enhancer       
<222> (185)...(505)
<223> ApoE/C1

<220> 
<221> promoter       
<222> (515)...(907)
<223> huSerpin A antitrypsin liver specific promoter

<220> 
<221> misc_feature   
<222> (1002)...(1007)
<223> kozak


<220> 
<221> sig_peptide    
<222> (1008)...(1091)


<220> 
<221> misc_feature   
<222> (1092)...(1094)
<223> FIX propeptide


<220> 
<221> intron         
<222> (1095)...(2532)
<223> FIX partial intron


<220> 
<221> misc_feature   
<222> (2533)...(2583)
<223> FIX propeptide


<220> 
<221> mat_peptide    
<222> (2584)...(3831)
<223> FIX mature


<220> 
<221> polyA_signal   
<222> (3943)...(4167)
<223> bGH poly(A)


<220> 
<221> repeat_region  
<222> (4281)...(4410)
<223> ITR

<400> 456
ctgcgcgctc gctcgctcac tgaggccgcc cgggcgtcgg gcgacctttg gtcgcccggc 60
ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg 120
gaggggtgga gtcgtgacgt aaagatctga tatcatcgat cgcgatgcat taattaagcg 180
gccgaggctc agaggcacac aggagtttct gggctcaccc tgcccccttc caacccctca 240
gttcccatcc tccagcagct gtttgtgtgc tgcctctgaa gtccacactg aacaaacttc 300
agcctactca tgtccctaaa atgggcaaac attgcaagca gcaaacagca aacacacagc 360
cctccctgcc tgctgacctt ggagctgggg cagaggtcag agacctctct gggcccatgc 420
cacctccaac atccactcga ccccttggaa tttcggtgga gaggagcaga ggttgtcctg 480
gcgtggttta ggtagtgtga gaggggtacc cggggatctt gctaccagtg gaacagccac 540
taaggattct gcagtgagag cagagggcca gctaagtggt actctcccag agactgtctg 600
actcacgcca ccccctccac cttggacaca ggacgctgtg gtttctgagc caggtacaat 660
gactcctttc ggtaagtgca gtggaagctg tacactgccc aggcaaagcg tccgggcagc 720
gtaggcgggc gactcagatc ccagccagtg gacttagccc ctgtttgctc ctccgataac 780
tggggtgacc ttggttaata ttcaccagca gcctcccccg ttgcccctct ggatccactg 840
cttaaatacg gacgaggaca gggccctgtc tcctcagctt caggcaccac cactgacctg 900
ggacagtgaa tgatccccct gatctgcggc ctcgacggta tcgataagct tgatatcgaa 960
ttctagtcgt cgaccacttt cacaatctgc tagcaaaggt tgccaccatg cagcgcgtga 1020
acatgattat ggccgagagc cctggcctga tcaccatctg cctgctgggc tacctgctga 1080
gcgccgagtg tacaggtttg tttccttttt taaaatacat tgagtatgct tgccttttag 1140
atatagaaat atctgatgct gtcttcttca ctaaattttg attacatgat ttgacagcaa 1200
tattgaagag tctaacagcc agcacgcagg ttggtaagta ctggttcttt gttagctagg 1260
ttttcttctt cttcattttt aaaactaaat agatcgacaa tgcttatgat gcatttatgt 1320
ttaataaaca ctgttcagtt catgatttgg tcatgtaatt cctgttagaa aacattcatc 1380
tccttggttt aaaaaaatta aaagtgggaa aacaaagaaa tagcagaata tagtgaaaaa 1440
aaataaccac attatttttg tttggactta ccactttgaa atcaaaatgg gaaacaaaag 1500
cacaaacaat ggccttattt acacaaaaag tctgatttta agatatatga catttcaagg 1560
tttcagaagt atgtaatgag gtgtgtctct aattttttaa attatatatc ttcaatttaa 1620
agttttagtt aaaacataaa gattaacctt tcattagcaa gctgttagtt atcaccaaag 1680
cttttcatgg attaggaaaa aatcattttg tctctatgtc aaacatcttg gagttgatat 1740
ttggggaaac acaatactca gttgagttcc ctaggggaga aaagcaagct taagaattga 1800
cataaagagt aggaagttag ctaatgcaac atatatcact ttgttttttc acaactacag 1860
tgactttatg tatttcccag aggaaggcat acagggaaga aattatccca tttggacaaa 1920
cagcatgttc tcacaggaag catttatcac acttacttgt caactttcta gaatcaaatc 1980
tagtagctga cagtaccagg atcaggggtg ccaaccctaa gcacccccag aaagctgact 2040
ggccctgtgg ttcccactcc agacatgatg tcagctgtga aatcgacgtc gctggaccat 2100
aattaggctt ctgttcttca ggagacattt gttcaaagtc atttgggcaa ccatattctg 2160
aaaacagccc agccagggtg atggatcact ttgcaaagat cctcaatgag ctattttcaa 2220
gtgatgacaa agtgtgaagt taaccgctca tttgagaact ttctttttca tccaaagtaa 2280
attcaaatat gattagaaat ctgacctttt attactggaa ttctcttgac taaaagtaaa 2340
attgaatttt aattcctaaa tctccatgtg tatacagtac tgtgggaaca tcacagattt 2400
tggctccatg ccctaaagag aaattggctt tcagattatt tggattaaaa acaaagactt 2460
tcttaagaga tgtaaaattt tcatgatgtt ttcttttttg ctaaaactaa agaattattc 2520
ttttacattt cagtgttcct ggaccacgag aacgccaaca agatcctgaa cagacccaag 2580
agatacaaca gcggcaagct ggaagagttc gtgcagggca acctggaacg cgagtgcatg 2640
gaagagaagt gcagcttcga agaggccaga gaggtgttcg agaacaccga gagaaccacc 2700
gagttctgga agcagtacgt ggacggcgac cagtgcgaga gcaacccttg tctgaacggc 2760
ggcagctgca aggacgacat caacagctac gagtgctggt gccccttcgg cttcgagggc 2820
aagaactgcg agctggacgt gacctgcaac atcaagaacg gcagatgcga gcagttctgc 2880
aagaacagcg ccgacaacaa ggtcgtgtgc tcctgcaccg agggctacag actggccgag 2940
aaccagaagt cctgcgagcc cgctgtgcct ttcccatgcg gaagagtgtc cgtgtcccag 3000
accagcaagc tgaccagagc cgagacagtg ttccccgacg tggactacgt gaacagcacc 3060
gaggccgaga caatcctgga caacatcacc cagagcaccc agtccttcaa cgacttcacc 3120
agagtcgtgg gcggcgagga tgctaagcct ggccagttcc cgtggcaggt ggtgctgaac 3180
ggaaaggtgg acgccttctg cggcggctcc atcgtgaacg agaagtggat cgtgacagcc 3240
gcccactgcg tggaaaccgg cgtgaagatc acagtggtgg ccggcgagca caacatcgag 3300
gaaaccgagc acacagagca gaaaagaaac gtgatcagga tcatccccca ccacaactac 3360
aacgccgcca tcaacaagta caaccacgat atcgccctgc tggaactgga cgagcccctg 3420
gtgctgaata gctacgtgac ccccatctgt atcgccgaca aagagtacac caacatcttt 3480
ctgaagttcg gcagcggcta cgtgtccggc tggggcagag tgtttcacaa gggcagatcc 3540
gctctggtgc tgcagtacct gagagtgcct ctggtggaca gagccacctg tctgagaagc 3600
accaagttca ccatctacaa caacatgttc tgcgctggct tccacgaggg cggcagagac 3660
tcttgtcagg gcgattctgg cggccctcac gtgacagagg tggaaggcac cagctttctg 3720
accggcatca tcagctgggg cgaggaatgc gccatgaagg ggaagtacgg catctacacc 3780
aaggtgtcca gatacgtgaa ctggatcaaa gaaaagacca agctgacata atgaaagatg 3840
gatttccaag gttaattcat tggaattgaa aattaacagc cccccccccc cccccctgca 3900
gatctcgagc cgaattcctg cagcccgggg gatcagcctc gactgtgcct tctagttgcc 3960
agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca 4020
ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta 4080
ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc 4140
atgctgggga tgcggtgggc tctatggctt ctgaggcgga aagaaccagc tggggctcga 4200
gatccactag actagtgtac acgcgtgata tcagatctgt tacgtagata agtagcatgg 4260
cgggttaatc attaactaca aggaacccct agtgatggag ttggccactc cctctctgcg 4320
cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg 4380
ggcggcctca gtgagcgagc gagcgcgcag                                  4410

<210> 457
<211> 4410
<212> DNA
<213> Artificial Sequence

<220> 
<223> ITR-ApoE/C1-antitrypsin promoter-FIXss-Pro-mini
      Intron-human FIX R318Y/R338E/T343R mouse
      optimized-bGHpolyA-ITR

<400> 457
ctgcgcgctc gctcgctcac tgaggccgcc cgggcgtcgg gcgacctttg gtcgcccggc 60
ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg 120
gaggggtgga gtcgtgacgt aaagatctga tatcatcgat cgcgatgcat taattaagcg 180
gccgaggctc agaggcacac aggagtttct gggctcaccc tgcccccttc caacccctca 240
gttcccatcc tccagcagct gtttgtgtgc tgcctctgaa gtccacactg aacaaacttc 300
agcctactca tgtccctaaa atgggcaaac attgcaagca gcaaacagca aacacacagc 360
cctccctgcc tgctgacctt ggagctgggg cagaggtcag agacctctct gggcccatgc 420
cacctccaac atccactcga ccccttggaa tttcggtgga gaggagcaga ggttgtcctg 480
gcgtggttta ggtagtgtga gaggggtacc cggggatctt gctaccagtg gaacagccac 540
taaggattct gcagtgagag cagagggcca gctaagtggt actctcccag agactgtctg 600
actcacgcca ccccctccac cttggacaca ggacgctgtg gtttctgagc caggtacaat 660
gactcctttc ggtaagtgca gtggaagctg tacactgccc aggcaaagcg tccgggcagc 720
gtaggcgggc gactcagatc ccagccagtg gacttagccc ctgtttgctc ctccgataac 780
tggggtgacc ttggttaata ttcaccagca gcctcccccg ttgcccctct ggatccactg 840
cttaaatacg gacgaggaca gggccctgtc tcctcagctt caggcaccac cactgacctg 900
ggacagtgaa tgatccccct gatctgcggc ctcgacggta tcgataagct tgatatcgaa 960
ttctagtcgt cgaccacttt cacaatctgc tagcaaaggt tgccaccatg cagcgcgtga 1020
acatgattat ggccgagagc cctggcctga tcaccatctg cctgctgggc tacctgctga 1080
gcgccgagtg tacaggtttg tttccttttt taaaatacat tgagtatgct tgccttttag 1140
atatagaaat atctgatgct gtcttcttca ctaaattttg attacatgat ttgacagcaa 1200
tattgaagag tctaacagcc agcacgcagg ttggtaagta ctggttcttt gttagctagg 1260
ttttcttctt cttcattttt aaaactaaat agatcgacaa tgcttatgat gcatttatgt 1320
ttaataaaca ctgttcagtt catgatttgg tcatgtaatt cctgttagaa aacattcatc 1380
tccttggttt aaaaaaatta aaagtgggaa aacaaagaaa tagcagaata tagtgaaaaa 1440
aaataaccac attatttttg tttggactta ccactttgaa atcaaaatgg gaaacaaaag 1500
cacaaacaat ggccttattt acacaaaaag tctgatttta agatatatga catttcaagg 1560
tttcagaagt atgtaatgag gtgtgtctct aattttttaa attatatatc ttcaatttaa 1620
agttttagtt aaaacataaa gattaacctt tcattagcaa gctgttagtt atcaccaaag 1680
cttttcatgg attaggaaaa aatcattttg tctctatgtc aaacatcttg gagttgatat 1740
ttggggaaac acaatactca gttgagttcc ctaggggaga aaagcaagct taagaattga 1800
cataaagagt aggaagttag ctaatgcaac atatatcact ttgttttttc acaactacag 1860
tgactttatg tatttcccag aggaaggcat acagggaaga aattatccca tttggacaaa 1920
cagcatgttc tcacaggaag catttatcac acttacttgt caactttcta gaatcaaatc 1980
tagtagctga cagtaccagg atcaggggtg ccaaccctaa gcacccccag aaagctgact 2040
ggccctgtgg ttcccactcc agacatgatg tcagctgtga aatcgacgtc gctggaccat 2100
aattaggctt ctgttcttca ggagacattt gttcaaagtc atttgggcaa ccatattctg 2160
aaaacagccc agccagggtg atggatcact ttgcaaagat cctcaatgag ctattttcaa 2220
gtgatgacaa agtgtgaagt taaccgctca tttgagaact ttctttttca tccaaagtaa 2280
attcaaatat gattagaaat ctgacctttt attactggaa ttctcttgac taaaagtaaa 2340
attgaatttt aattcctaaa tctccatgtg tatacagtac tgtgggaaca tcacagattt 2400
tggctccatg ccctaaagag aaattggctt tcagattatt tggattaaaa acaaagactt 2460
tcttaagaga tgtaaaattt tcatgatgtt ttcttttttg ctaaaactaa agaattattc 2520
ttttacattt cagtgttcct ggaccacgag aacgccaaca agatcctgaa cagacccaag 2580
agatacaaca gcggcaagct ggaagagttc gtgcagggca acctggaacg cgagtgcatg 2640
gaagagaagt gcagcttcga agaggccaga gaggtgttcg agaacaccga gagaaccacc 2700
gagttctgga agcagtacgt ggacggcgac cagtgcgaga gcaacccttg tctgaacggc 2760
ggcagctgca aggacgacat caacagctac gagtgctggt gccccttcgg cttcgagggc 2820
aagaactgcg agctggacgt gacctgcaac atcaagaacg gcagatgcga gcagttctgc 2880
aagaacagcg ccgacaacaa ggtcgtgtgc tcctgcaccg agggctacag actggccgag 2940
aaccagaagt cctgcgagcc cgctgtgcct ttcccatgcg gaagagtgtc cgtgtcccag 3000
accagcaagc tgaccagagc cgagacagtg ttccccgacg tggactacgt gaacagcacc 3060
gaggccgaga caatcctgga caacatcacc cagagcaccc agtccttcaa cgacttcacc 3120
agagtcgtgg gcggcgagga tgctaagcct ggccagttcc cgtggcaggt ggtgctgaac 3180
ggaaaggtgg acgccttctg cggcggctcc atcgtgaacg agaagtggat cgtgacagcc 3240
gcccactgcg tggaaaccgg cgtgaagatc acagtggtgg ccggcgagca caacatcgag 3300
gaaaccgagc acacagagca gaaaagaaac gtgatcagga tcatccccca ccacaactac 3360
aacgccgcca tcaacaagta caaccacgat atcgccctgc tggaactgga cgagcccctg 3420
gtgctgaata gctacgtgac ccccatctgt atcgccgaca aagagtacac caacatcttt 3480
ctgaagttcg gcagcggcta cgtgtccggc tggggcagag tgtttcacaa gggctactcc 3540
gctctggtgc tgcagtacct gagagtgcct ctggtggaca gagccacctg tctggaaagc 3600
accaagttca gaatctacaa caacatgttc tgcgctggct tccacgaggg cggcagagac 3660
tcttgtcagg gcgattctgg cggccctcac gtgacagagg tggaaggcac cagctttctg 3720
accggcatca tcagctgggg cgaggaatgc gccatgaagg ggaagtacgg catctacacc 3780
aaggtgtcca gatacgtgaa ctggatcaaa gaaaagacca agctgacata atgaaagatg 3840
gatttccaag gttaattcat tggaattgaa aattaacagc cccccccccc cccccctgca 3900
gatctcgagc cgaattcctg cagcccgggg gatcagcctc gactgtgcct tctagttgcc 3960
agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca 4020
ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta 4080
ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc 4140
atgctgggga tgcggtgggc tctatggctt ctgaggcgga aagaaccagc tggggctcga 4200
gatccactag actagtgtac acgcgtgata tcagatctgt tacgtagata agtagcatgg 4260
cgggttaatc attaactaca aggaacccct agtgatggag ttggccactc cctctctgcg 4320
cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg 4380
ggcggcctca gtgagcgagc gagcgcgcag                                  4410

<210> 458
<211> 4410
<212> DNA
<213> Artificial Sequence

<220> 
<223> ITR-ApoE/C1-antitrypsin promoter-FIXss-Pro-mini
      Intron-human FIX R338L mouse
      optimized-bGHpolyA-ITR

<400> 458
ctgcgcgctc gctcgctcac tgaggccgcc cgggcgtcgg gcgacctttg gtcgcccggc 60
ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg 120
gaggggtgga gtcgtgacgt aaagatctga tatcatcgat cgcgatgcat taattaagcg 180
gccgaggctc agaggcacac aggagtttct gggctcaccc tgcccccttc caacccctca 240
gttcccatcc tccagcagct gtttgtgtgc tgcctctgaa gtccacactg aacaaacttc 300
agcctactca tgtccctaaa atgggcaaac attgcaagca gcaaacagca aacacacagc 360
cctccctgcc tgctgacctt ggagctgggg cagaggtcag agacctctct gggcccatgc 420
cacctccaac atccactcga ccccttggaa tttcggtgga gaggagcaga ggttgtcctg 480
gcgtggttta ggtagtgtga gaggggtacc cggggatctt gctaccagtg gaacagccac 540
taaggattct gcagtgagag cagagggcca gctaagtggt actctcccag agactgtctg 600
actcacgcca ccccctccac cttggacaca ggacgctgtg gtttctgagc caggtacaat 660
gactcctttc ggtaagtgca gtggaagctg tacactgccc aggcaaagcg tccgggcagc 720
gtaggcgggc gactcagatc ccagccagtg gacttagccc ctgtttgctc ctccgataac 780
tggggtgacc ttggttaata ttcaccagca gcctcccccg ttgcccctct ggatccactg 840
cttaaatacg gacgaggaca gggccctgtc tcctcagctt caggcaccac cactgacctg 900
ggacagtgaa tgatccccct gatctgcggc ctcgacggta tcgataagct tgatatcgaa 960
ttctagtcgt cgaccacttt cacaatctgc tagcaaaggt tgccaccatg cagcgcgtga 1020
acatgattat ggccgagagc cctggcctga tcaccatctg cctgctgggc tacctgctga 1080
gcgccgagtg tacaggtttg tttccttttt taaaatacat tgagtatgct tgccttttag 1140
atatagaaat atctgatgct gtcttcttca ctaaattttg attacatgat ttgacagcaa 1200
tattgaagag tctaacagcc agcacgcagg ttggtaagta ctggttcttt gttagctagg 1260
ttttcttctt cttcattttt aaaactaaat agatcgacaa tgcttatgat gcatttatgt 1320
ttaataaaca ctgttcagtt catgatttgg tcatgtaatt cctgttagaa aacattcatc 1380
tccttggttt aaaaaaatta aaagtgggaa aacaaagaaa tagcagaata tagtgaaaaa 1440
aaataaccac attatttttg tttggactta ccactttgaa atcaaaatgg gaaacaaaag 1500
cacaaacaat ggccttattt acacaaaaag tctgatttta agatatatga catttcaagg 1560
tttcagaagt atgtaatgag gtgtgtctct aattttttaa attatatatc ttcaatttaa 1620
agttttagtt aaaacataaa gattaacctt tcattagcaa gctgttagtt atcaccaaag 1680
cttttcatgg attaggaaaa aatcattttg tctctatgtc aaacatcttg gagttgatat 1740
ttggggaaac acaatactca gttgagttcc ctaggggaga aaagcaagct taagaattga 1800
cataaagagt aggaagttag ctaatgcaac atatatcact ttgttttttc acaactacag 1860
tgactttatg tatttcccag aggaaggcat acagggaaga aattatccca tttggacaaa 1920
cagcatgttc tcacaggaag catttatcac acttacttgt caactttcta gaatcaaatc 1980
tagtagctga cagtaccagg atcaggggtg ccaaccctaa gcacccccag aaagctgact 2040
ggccctgtgg ttcccactcc agacatgatg tcagctgtga aatcgacgtc gctggaccat 2100
aattaggctt ctgttcttca ggagacattt gttcaaagtc atttgggcaa ccatattctg 2160
aaaacagccc agccagggtg atggatcact ttgcaaagat cctcaatgag ctattttcaa 2220
gtgatgacaa agtgtgaagt taaccgctca tttgagaact ttctttttca tccaaagtaa 2280
attcaaatat gattagaaat ctgacctttt attactggaa ttctcttgac taaaagtaaa 2340
attgaatttt aattcctaaa tctccatgtg tatacagtac tgtgggaaca tcacagattt 2400
tggctccatg ccctaaagag aaattggctt tcagattatt tggattaaaa acaaagactt 2460
tcttaagaga tgtaaaattt tcatgatgtt ttcttttttg ctaaaactaa agaattattc 2520
ttttacattt cagtgttcct ggaccacgag aacgccaaca agatcctgaa cagacccaag 2580
agatacaaca gcggcaagct ggaagagttc gtgcagggca acctggaacg cgagtgcatg 2640
gaagagaagt gcagcttcga agaggccaga gaggtgttcg agaacaccga gagaaccacc 2700
gagttctgga agcagtacgt ggacggcgac cagtgcgaga gcaacccttg tctgaacggc 2760
ggcagctgca aggacgacat caacagctac gagtgctggt gccccttcgg cttcgagggc 2820
aagaactgcg agctggacgt gacctgcaac atcaagaacg gcagatgcga gcagttctgc 2880
aagaacagcg ccgacaacaa ggtcgtgtgc tcctgcaccg agggctacag actggccgag 2940
aaccagaagt cctgcgagcc cgctgtgcct ttcccatgcg gaagagtgtc cgtgtcccag 3000
accagcaagc tgaccagagc cgagacagtg ttccccgacg tggactacgt gaacagcacc 3060
gaggccgaga caatcctgga caacatcacc cagagcaccc agtccttcaa cgacttcacc 3120
agagtcgtgg gcggcgagga tgctaagcct ggccagttcc cgtggcaggt ggtgctgaac 3180
ggaaaggtgg acgccttctg cggcggctcc atcgtgaacg agaagtggat cgtgacagcc 3240
gcccactgcg tggaaaccgg cgtgaagatc acagtggtgg ccggcgagca caacatcgag 3300
gaaaccgagc acacagagca gaaaagaaac gtgatcagga tcatccccca ccacaactac 3360
aacgccgcca tcaacaagta caaccacgat atcgccctgc tggaactgga cgagcccctg 3420
gtgctgaata gctacgtgac ccccatctgt atcgccgaca aagagtacac caacatcttt 3480
ctgaagttcg gcagcggcta cgtgtccggc tggggcagag tgtttcacaa gggcagatcc 3540
gctctggtgc tgcagtacct gagagtgcct ctggtggaca gagccacctg tctgctgagc 3600
accaagttca ccatctacaa caacatgttc tgcgctggct tccacgaggg cggcagagac 3660
tcttgtcagg gcgattctgg cggccctcac gtgacagagg tggaaggcac cagctttctg 3720
accggcatca tcagctgggg cgaggaatgc gccatgaagg ggaagtacgg catctacacc 3780
aaggtgtcca gatacgtgaa ctggatcaaa gaaaagacca agctgacata atgaaagatg 3840
gatttccaag gttaattcat tggaattgaa aattaacagc cccccccccc cccccctgca 3900
gatctcgagc cgaattcctg cagcccgggg gatcagcctc gactgtgcct tctagttgcc 3960
agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca 4020
ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta 4080
ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc 4140
atgctgggga tgcggtgggc tctatggctt ctgaggcgga aagaaccagc tggggctcga 4200
gatccactag actagtgtac acgcgtgata tcagatctgt tacgtagata agtagcatgg 4260
cgggttaatc attaactaca aggaacccct agtgatggag ttggccactc cctctctgcg 4320
cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg 4380
ggcggcctca gtgagcgagc gagcgcgcag                                  4410

<210> 459
<211> 4410
<212> DNA
<213> Artificial Sequence

<220> 
<223> ITR-ApoE/C1-antitrypsin promoter-FIXss-Pro-mini
      Intron-human WT FIX-bGHpolyA-ITR

<400> 459
ctgcgcgctc gctcgctcac tgaggccgcc cgggcgtcgg gcgacctttg gtcgcccggc 60
ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg 120
gaggggtgga gtcgtgacgt aaagatctga tatcatcgat cgcgatgcat taattaagcg 180
gccgaggctc agaggcacac aggagtttct gggctcaccc tgcccccttc caacccctca 240
gttcccatcc tccagcagct gtttgtgtgc tgcctctgaa gtccacactg aacaaacttc 300
agcctactca tgtccctaaa atgggcaaac attgcaagca gcaaacagca aacacacagc 360
cctccctgcc tgctgacctt ggagctgggg cagaggtcag agacctctct gggcccatgc 420
cacctccaac atccactcga ccccttggaa tttcggtgga gaggagcaga ggttgtcctg 480
gcgtggttta ggtagtgtga gaggggtacc cggggatctt gctaccagtg gaacagccac 540
taaggattct gcagtgagag cagagggcca gctaagtggt actctcccag agactgtctg 600
actcacgcca ccccctccac cttggacaca ggacgctgtg gtttctgagc caggtacaat 660
gactcctttc ggtaagtgca gtggaagctg tacactgccc aggcaaagcg tccgggcagc 720
gtaggcgggc gactcagatc ccagccagtg gacttagccc ctgtttgctc ctccgataac 780
tggggtgacc ttggttaata ttcaccagca gcctcccccg ttgcccctct ggatccactg 840
cttaaatacg gacgaggaca gggccctgtc tcctcagctt caggcaccac cactgacctg 900
ggacagtgaa tgatccccct gatctgcggc ctcgacggta tcgataagct tgatatcgaa 960
ttctagtcgt cgaccacttt cacaatctgc tagcaaaggt tgccaccatg cagcgcgtga 1020
acatgatcat ggcagaatca ccaggcctca tcaccatctg ccttttagga tatctactca 1080
gtgctgaatg tacaggtttg tttccttttt taaaatacat tgagtatgct tgccttttag 1140
atatagaaat atctgatgct gtcttcttca ctaaattttg attacatgat ttgacagcaa 1200
tattgaagag tctaacagcc agcacgcagg ttggtaagta ctggttcttt gttagctagg 1260
ttttcttctt cttcattttt aaaactaaat agatcgacaa tgcttatgat gcatttatgt 1320
ttaataaaca ctgttcagtt catgatttgg tcatgtaatt cctgttagaa aacattcatc 1380
tccttggttt aaaaaaatta aaagtgggaa aacaaagaaa tagcagaata tagtgaaaaa 1440
aaataaccac attatttttg tttggactta ccactttgaa atcaaaatgg gaaacaaaag 1500
cacaaacaat ggccttattt acacaaaaag tctgatttta agatatatga catttcaagg 1560
tttcagaagt atgtaatgag gtgtgtctct aattttttaa attatatatc ttcaatttaa 1620
agttttagtt aaaacataaa gattaacctt tcattagcaa gctgttagtt atcaccaaag 1680
cttttcatgg attaggaaaa aatcattttg tctctatgtc aaacatcttg gagttgatat 1740
ttggggaaac acaatactca gttgagttcc ctaggggaga aaagcaagct taagaattga 1800
cataaagagt aggaagttag ctaatgcaac atatatcact ttgttttttc acaactacag 1860
tgactttatg tatttcccag aggaaggcat acagggaaga aattatccca tttggacaaa 1920
cagcatgttc tcacaggaag catttatcac acttacttgt caactttcta gaatcaaatc 1980
tagtagctga cagtaccagg atcaggggtg ccaaccctaa gcacccccag aaagctgact 2040
ggccctgtgg ttcccactcc agacatgatg tcagctgtga aatcgacgtc gctggaccat 2100
aattaggctt ctgttcttca ggagacattt gttcaaagtc atttgggcaa ccatattctg 2160
aaaacagccc agccagggtg atggatcact ttgcaaagat cctcaatgag ctattttcaa 2220
gtgatgacaa agtgtgaagt taaccgctca tttgagaact ttctttttca tccaaagtaa 2280
attcaaatat gattagaaat ctgacctttt attactggaa ttctcttgac taaaagtaaa 2340
attgaatttt aattcctaaa tctccatgtg tatacagtac tgtgggaaca tcacagattt 2400
tggctccatg ccctaaagag aaattggctt tcagattatt tggattaaaa acaaagactt 2460
tcttaagaga tgtaaaattt tcatgatgtt ttcttttttg ctaaaactaa agaattattc 2520
ttttacattt cagtttttct tgatcatgaa aacgccaaca aaattctgaa tcggccaaag 2580
aggtataatt caggtaaatt ggaagagttt gttcaaggga accttgagag agaatgtatg 2640
gaagaaaagt gtagttttga agaagcacga gaagtttttg aaaacactga aagaacaact 2700
gaattttgga agcagtatgt tgatggagat cagtgtgagt ccaatccatg tttaaatggc 2760
ggcagttgca aggatgacat taattcctat gaatgttggt gtccctttgg atttgaagga 2820
aagaactgtg aattagatgt aacatgtaac attaagaatg gcagatgcga gcagttttgt 2880
aaaaatagtg ctgataacaa ggtggtttgc tcctgtactg agggatatcg acttgcagaa 2940
aaccagaagt cctgtgaacc agcagtgcca tttccatgtg gaagagtttc tgtttcacaa 3000
acttctaagc tcacccgtgc tgagactgtt tttcctgatg tggactatgt aaattctact 3060
gaagctgaaa ccattttgga taacatcact caaagcaccc aatcatttaa tgacttcact 3120
cgggttgttg gtggagaaga tgccaaacca ggtcaattcc cttggcaggt tgttttgaat 3180
ggtaaagttg atgcattctg tggaggctct atcgttaatg aaaaatggat tgtaactgct 3240
gcccactgtg ttgaaactgg tgttaaaatt acagttgtcg caggtgaaca taatattgag 3300
gagacagaac atacagagca aaagcgaaat gtgattcgaa ttattcctca ccacaactac 3360
aatgcagcta ttaataagta caaccatgac attgcccttc tggaactgga cgaaccctta 3420
gtgctaaaca gctacgttac acctatttgc attgctgaca aggaatacac gaacatcttc 3480
ctcaaatttg gatctggcta tgtaagtggc tggggaagag tcttccacaa agggagatca 3540
gctttagttc ttcagtacct tagagttcca cttgttgacc gagccacatg tcttcgatct 3600
acaaagttca ccatctataa caacatgttc tgtgctggct tccatgaagg aggtagagat 3660
tcatgtcaag gagatagtgg gggaccccat gttactgaag tggaagggac cagtttctta 3720
actggaatta ttagctgggg tgaagagtgt gcaatgaaag gcaaatatgg aatatatacc 3780
aaggtatccc ggtatgtcaa ctggattaag gaaaaaacaa agctcactta atgaaagatg 3840
gatttccaag gttaattcat tggaattgaa aattaacagc cccccccccc cccccctgca 3900
gatctcgagc cgaattcctg cagcccgggg gatcagcctc gactgtgcct tctagttgcc 3960
agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca 4020
ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta 4080
ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc 4140
atgctgggga tgcggtgggc tctatggctt ctgaggcgga aagaaccagc tggggctcga 4200
gatccactag actagtgtac acgcgtgata tcagatctgt tacgtagata agtagcatgg 4260
cgggttaatc attaactaca aggaacccct agtgatggag ttggccactc cctctctgcg 4320
cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg 4380
ggcggcctca gtgagcgagc gagcgcgcag                                  4410

<210> 460
<211> 4410
<212> DNA
<213> Artificial Sequence

<220> 
<223> ITR-ApoE/C1-antitrypsin promoter-FIXss-Pro-mini
      Intron-human FIX R318Y/R338E/T343R-bGHpolyA-ITR

<400> 460
ctgcgcgctc gctcgctcac tgaggccgcc cgggcgtcgg gcgacctttg gtcgcccggc 60
ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg 120
gaggggtgga gtcgtgacgt aaagatctga tatcatcgat cgcgatgcat taattaagcg 180
gccgaggctc agaggcacac aggagtttct gggctcaccc tgcccccttc caacccctca 240
gttcccatcc tccagcagct gtttgtgtgc tgcctctgaa gtccacactg aacaaacttc 300
agcctactca tgtccctaaa atgggcaaac attgcaagca gcaaacagca aacacacagc 360
cctccctgcc tgctgacctt ggagctgggg cagaggtcag agacctctct gggcccatgc 420
cacctccaac atccactcga ccccttggaa tttcggtgga gaggagcaga ggttgtcctg 480
gcgtggttta ggtagtgtga gaggggtacc cggggatctt gctaccagtg gaacagccac 540
taaggattct gcagtgagag cagagggcca gctaagtggt actctcccag agactgtctg 600
actcacgcca ccccctccac cttggacaca ggacgctgtg gtttctgagc caggtacaat 660
gactcctttc ggtaagtgca gtggaagctg tacactgccc aggcaaagcg tccgggcagc 720
gtaggcgggc gactcagatc ccagccagtg gacttagccc ctgtttgctc ctccgataac 780
tggggtgacc ttggttaata ttcaccagca gcctcccccg ttgcccctct ggatccactg 840
cttaaatacg gacgaggaca gggccctgtc tcctcagctt caggcaccac cactgacctg 900
ggacagtgaa tgatccccct gatctgcggc ctcgacggta tcgataagct tgatatcgaa 960
ttctagtcgt cgaccacttt cacaatctgc tagcaaaggt tgccaccatg cagcgcgtga 1020
acatgatcat ggcagaatca ccaggcctca tcaccatctg ccttttagga tatctactca 1080
gtgctgaatg tacaggtttg tttccttttt taaaatacat tgagtatgct tgccttttag 1140
atatagaaat atctgatgct gtcttcttca ctaaattttg attacatgat ttgacagcaa 1200
tattgaagag tctaacagcc agcacgcagg ttggtaagta ctggttcttt gttagctagg 1260
ttttcttctt cttcattttt aaaactaaat agatcgacaa tgcttatgat gcatttatgt 1320
ttaataaaca ctgttcagtt catgatttgg tcatgtaatt cctgttagaa aacattcatc 1380
tccttggttt aaaaaaatta aaagtgggaa aacaaagaaa tagcagaata tagtgaaaaa 1440
aaataaccac attatttttg tttggactta ccactttgaa atcaaaatgg gaaacaaaag 1500
cacaaacaat ggccttattt acacaaaaag tctgatttta agatatatga catttcaagg 1560
tttcagaagt atgtaatgag gtgtgtctct aattttttaa attatatatc ttcaatttaa 1620
agttttagtt aaaacataaa gattaacctt tcattagcaa gctgttagtt atcaccaaag 1680
cttttcatgg attaggaaaa aatcattttg tctctatgtc aaacatcttg gagttgatat 1740
ttggggaaac acaatactca gttgagttcc ctaggggaga aaagcaagct taagaattga 1800
cataaagagt aggaagttag ctaatgcaac atatatcact ttgttttttc acaactacag 1860
tgactttatg tatttcccag aggaaggcat acagggaaga aattatccca tttggacaaa 1920
cagcatgttc tcacaggaag catttatcac acttacttgt caactttcta gaatcaaatc 1980
tagtagctga cagtaccagg atcaggggtg ccaaccctaa gcacccccag aaagctgact 2040
ggccctgtgg ttcccactcc agacatgatg tcagctgtga aatcgacgtc gctggaccat 2100
aattaggctt ctgttcttca ggagacattt gttcaaagtc atttgggcaa ccatattctg 2160
aaaacagccc agccagggtg atggatcact ttgcaaagat cctcaatgag ctattttcaa 2220
gtgatgacaa agtgtgaagt taaccgctca tttgagaact ttctttttca tccaaagtaa 2280
attcaaatat gattagaaat ctgacctttt attactggaa ttctcttgac taaaagtaaa 2340
attgaatttt aattcctaaa tctccatgtg tatacagtac tgtgggaaca tcacagattt 2400
tggctccatg ccctaaagag aaattggctt tcagattatt tggattaaaa acaaagactt 2460
tcttaagaga tgtaaaattt tcatgatgtt ttcttttttg ctaaaactaa agaattattc 2520
ttttacattt cagtttttct tgatcatgaa aacgccaaca aaattctgaa tcggccaaag 2580
aggtataatt caggtaaatt ggaagagttt gttcaaggga accttgagag agaatgtatg 2640
gaagaaaagt gtagttttga agaagcacga gaagtttttg aaaacactga aagaacaact 2700
gaattttgga agcagtatgt tgatggagat cagtgtgagt ccaatccatg tttaaatggc 2760
ggcagttgca aggatgacat taattcctat gaatgttggt gtccctttgg atttgaagga 2820
aagaactgtg aattagatgt aacatgtaac attaagaatg gcagatgcga gcagttttgt 2880
aaaaatagtg ctgataacaa ggtggtttgc tcctgtactg agggatatcg acttgcagaa 2940
aaccagaagt cctgtgaacc agcagtgcca tttccatgtg gaagagtttc tgtttcacaa 3000
acttctaagc tcacccgtgc tgagactgtt tttcctgatg tggactatgt aaattctact 3060
gaagctgaaa ccattttgga taacatcact caaagcaccc aatcatttaa tgacttcact 3120
cgggttgttg gtggagaaga tgccaaacca ggtcaattcc cttggcaggt tgttttgaat 3180
ggtaaagttg atgcattctg tggaggctct atcgttaatg aaaaatggat tgtaactgct 3240
gcccactgtg ttgaaactgg tgttaaaatt acagttgtcg caggtgaaca taatattgag 3300
gagacagaac atacagagca aaagcgaaat gtgattcgaa ttattcctca ccacaactac 3360
aatgcagcta ttaataagta caaccatgac attgcccttc tggaactgga cgaaccctta 3420
gtgctaaaca gctacgttac acctatttgc attgctgaca aggaatacac gaacatcttc 3480
ctcaaatttg gatctggcta tgtaagtggc tggggaagag tcttccacaa agggtactca 3540
gctttagttc ttcagtacct tagagttcca cttgttgacc gagccacatg tcttgaatct 3600
acaaagttca ggatctataa caacatgttc tgtgctggct tccatgaagg aggtagagat 3660
tcatgtcaag gagatagtgg gggaccccat gttactgaag tggaagggac cagtttctta 3720
actggaatta ttagctgggg tgaagagtgt gcaatgaaag gcaaatatgg aatatatacc 3780
aaggtatccc ggtatgtcaa ctggattaag gaaaaaacaa agctcactta atgaaagatg 3840
gatttccaag gttaattcat tggaattgaa aattaacagc cccccccccc cccccctgca 3900
gatctcgagc cgaattcctg cagcccgggg gatcagcctc gactgtgcct tctagttgcc 3960
agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca 4020
ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta 4080
ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc 4140
atgctgggga tgcggtgggc tctatggctt ctgaggcgga aagaaccagc tggggctcga 4200
gatccactag actagtgtac acgcgtgata tcagatctgt tacgtagata agtagcatgg 4260
cgggttaatc attaactaca aggaacccct agtgatggag ttggccactc cctctctgcg 4320
cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg 4380
ggcggcctca gtgagcgagc gagcgcgcag                                  4410

<210> 461
<211> 4410
<212> DNA
<213> Artificial Sequence

<220> 
<223> ITR-ApoE/C1-antitrypsin promoter-FIXss-Pro-mini
      Intron-human FIX R338L-bGHpolyA-ITR

<400> 461
ctgcgcgctc gctcgctcac tgaggccgcc cgggcgtcgg gcgacctttg gtcgcccggc 60
ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg 120
gaggggtgga gtcgtgacgt aaagatctga tatcatcgat cgcgatgcat taattaagcg 180
gccgaggctc agaggcacac aggagtttct gggctcaccc tgcccccttc caacccctca 240
gttcccatcc tccagcagct gtttgtgtgc tgcctctgaa gtccacactg aacaaacttc 300
agcctactca tgtccctaaa atgggcaaac attgcaagca gcaaacagca aacacacagc 360
cctccctgcc tgctgacctt ggagctgggg cagaggtcag agacctctct gggcccatgc 420
cacctccaac atccactcga ccccttggaa tttcggtgga gaggagcaga ggttgtcctg 480
gcgtggttta ggtagtgtga gaggggtacc cggggatctt gctaccagtg gaacagccac 540
taaggattct gcagtgagag cagagggcca gctaagtggt actctcccag agactgtctg 600
actcacgcca ccccctccac cttggacaca ggacgctgtg gtttctgagc caggtacaat 660
gactcctttc ggtaagtgca gtggaagctg tacactgccc aggcaaagcg tccgggcagc 720
gtaggcgggc gactcagatc ccagccagtg gacttagccc ctgtttgctc ctccgataac 780
tggggtgacc ttggttaata ttcaccagca gcctcccccg ttgcccctct ggatccactg 840
cttaaatacg gacgaggaca gggccctgtc tcctcagctt caggcaccac cactgacctg 900
ggacagtgaa tgatccccct gatctgcggc ctcgacggta tcgataagct tgatatcgaa 960
ttctagtcgt cgaccacttt cacaatctgc tagcaaaggt tgccaccatg cagcgcgtga 1020
acatgatcat ggcagaatca ccaggcctca tcaccatctg ccttttagga tatctactca 1080
gtgctgaatg tacaggtttg tttccttttt taaaatacat tgagtatgct tgccttttag 1140
atatagaaat atctgatgct gtcttcttca ctaaattttg attacatgat ttgacagcaa 1200
tattgaagag tctaacagcc agcacgcagg ttggtaagta ctggttcttt gttagctagg 1260
ttttcttctt cttcattttt aaaactaaat agatcgacaa tgcttatgat gcatttatgt 1320
ttaataaaca ctgttcagtt catgatttgg tcatgtaatt cctgttagaa aacattcatc 1380
tccttggttt aaaaaaatta aaagtgggaa aacaaagaaa tagcagaata tagtgaaaaa 1440
aaataaccac attatttttg tttggactta ccactttgaa atcaaaatgg gaaacaaaag 1500
cacaaacaat ggccttattt acacaaaaag tctgatttta agatatatga catttcaagg 1560
tttcagaagt atgtaatgag gtgtgtctct aattttttaa attatatatc ttcaatttaa 1620
agttttagtt aaaacataaa gattaacctt tcattagcaa gctgttagtt atcaccaaag 1680
cttttcatgg attaggaaaa aatcattttg tctctatgtc aaacatcttg gagttgatat 1740
ttggggaaac acaatactca gttgagttcc ctaggggaga aaagcaagct taagaattga 1800
cataaagagt aggaagttag ctaatgcaac atatatcact ttgttttttc acaactacag 1860
tgactttatg tatttcccag aggaaggcat acagggaaga aattatccca tttggacaaa 1920
cagcatgttc tcacaggaag catttatcac acttacttgt caactttcta gaatcaaatc 1980
tagtagctga cagtaccagg atcaggggtg ccaaccctaa gcacccccag aaagctgact 2040
ggccctgtgg ttcccactcc agacatgatg tcagctgtga aatcgacgtc gctggaccat 2100
aattaggctt ctgttcttca ggagacattt gttcaaagtc atttgggcaa ccatattctg 2160
aaaacagccc agccagggtg atggatcact ttgcaaagat cctcaatgag ctattttcaa 2220
gtgatgacaa agtgtgaagt taaccgctca tttgagaact ttctttttca tccaaagtaa 2280
attcaaatat gattagaaat ctgacctttt attactggaa ttctcttgac taaaagtaaa 2340
attgaatttt aattcctaaa tctccatgtg tatacagtac tgtgggaaca tcacagattt 2400
tggctccatg ccctaaagag aaattggctt tcagattatt tggattaaaa acaaagactt 2460
tcttaagaga tgtaaaattt tcatgatgtt ttcttttttg ctaaaactaa agaattattc 2520
ttttacattt cagtttttct tgatcatgaa aacgccaaca aaattctgaa tcggccaaag 2580
aggtataatt caggtaaatt ggaagagttt gttcaaggga accttgagag agaatgtatg 2640
gaagaaaagt gtagttttga agaagcacga gaagtttttg aaaacactga aagaacaact 2700
gaattttgga agcagtatgt tgatggagat cagtgtgagt ccaatccatg tttaaatggc 2760
ggcagttgca aggatgacat taattcctat gaatgttggt gtccctttgg atttgaagga 2820
aagaactgtg aattagatgt aacatgtaac attaagaatg gcagatgcga gcagttttgt 2880
aaaaatagtg ctgataacaa ggtggtttgc tcctgtactg agggatatcg acttgcagaa 2940
aaccagaagt cctgtgaacc agcagtgcca tttccatgtg gaagagtttc tgtttcacaa 3000
acttctaagc tcacccgtgc tgagactgtt tttcctgatg tggactatgt aaattctact 3060
gaagctgaaa ccattttgga taacatcact caaagcaccc aatcatttaa tgacttcact 3120
cgggttgttg gtggagaaga tgccaaacca ggtcaattcc cttggcaggt tgttttgaat 3180
ggtaaagttg atgcattctg tggaggctct atcgttaatg aaaaatggat tgtaactgct 3240
gcccactgtg ttgaaactgg tgttaaaatt acagttgtcg caggtgaaca taatattgag 3300
gagacagaac atacagagca aaagcgaaat gtgattcgaa ttattcctca ccacaactac 3360
aatgcagcta ttaataagta caaccatgac attgcccttc tggaactgga cgaaccctta 3420
gtgctaaaca gctacgttac acctatttgc attgctgaca aggaatacac gaacatcttc 3480
ctcaaatttg gatctggcta tgtaagtggc tggggaagag tcttccacaa agggagatca 3540
gctttagttc ttcagtacct tagagttcca cttgttgacc gagccacatg tcttctgtct 3600
acaaagttca ccatctataa caacatgttc tgtgctggct tccatgaagg aggtagagat 3660
tcatgtcaag gagatagtgg gggaccccat gttactgaag tggaagggac cagtttctta 3720
actggaatta ttagctgggg tgaagagtgt gcaatgaaag gcaaatatgg aatatatacc 3780
aaggtatccc ggtatgtcaa ctggattaag gaaaaaacaa agctcactta atgaaagatg 3840
gatttccaag gttaattcat tggaattgaa aattaacagc cccccccccc cccccctgca 3900
gatctcgagc cgaattcctg cagcccgggg gatcagcctc gactgtgcct tctagttgcc 3960
agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca 4020
ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta 4080
ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc 4140
atgctgggga tgcggtgggc tctatggctt ctgaggcgga aagaaccagc tggggctcga 4200
gatccactag actagtgtac acgcgtgata tcagatctgt tacgtagata agtagcatgg 4260
cgggttaatc attaactaca aggaacccct agtgatggag ttggccactc cctctctgcg 4320
cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg 4380
ggcggcctca gtgagcgagc gagcgcgcag                                  4410

<210> 462
<211> 2824
<212> DNA
<213> Artificial Sequence

<220> 
<223> FIXss-Pro-mini Intron-Pro-human wild type FIX
      mouse optimized

<400> 462
atgcagcgcg tgaacatgat tatggccgag agccctggcc tgatcaccat ctgcctgctg 60
ggctacctgc tgagcgccga gtgtacaggt ttgtttcctt ttttaaaata cattgagtat 120
gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat 180
gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactggttc 240
tttgttagct aggttttctt cttcttcatt tttaaaacta aatagatcga caatgcttat 300
gatgcattta tgtttaataa acactgttca gttcatgatt tggtcatgta attcctgtta 360
gaaaacattc atctccttgg tttaaaaaaa ttaaaagtgg gaaaacaaag aaatagcaga 420
atatagtgaa aaaaaataac cacattattt ttgtttggac ttaccacttt gaaatcaaaa 480
tgggaaacaa aagcacaaac aatggcctta tttacacaaa aagtctgatt ttaagatata 540
tgacatttca aggtttcaga agtatgtaat gaggtgtgtc tctaattttt taaattatat 600
atcttcaatt taaagtttta gttaaaacat aaagattaac ctttcattag caagctgtta 660
gttatcacca aagcttttca tggattagga aaaaatcatt ttgtctctat gtcaaacatc 720
ttggagttga tatttgggga aacacaatac tcagttgagt tccctagggg agaaaagcaa 780
gcttaagaat tgacataaag agtaggaagt tagctaatgc aacatatatc actttgtttt 840
ttcacaacta cagtgacttt atgtatttcc cagaggaagg catacaggga agaaattatc 900
ccatttggac aaacagcatg ttctcacagg aagcatttat cacacttact tgtcaacttt 960
ctagaatcaa atctagtagc tgacagtacc aggatcaggg gtgccaaccc taagcacccc 1020
cagaaagctg actggccctg tggttcccac tccagacatg atgtcagctg tgaaatcgac 1080
gtcgctggac cataattagg cttctgttct tcaggagaca tttgttcaaa gtcatttggg 1140
caaccatatt ctgaaaacag cccagccagg gtgatggatc actttgcaaa gatcctcaat 1200
gagctatttt caagtgatga caaagtgtga agttaaccgc tcatttgaga actttctttt 1260
tcatccaaag taaattcaaa tatgattaga aatctgacct tttattactg gaattctctt 1320
gactaaaagt aaaattgaat tttaattcct aaatctccat gtgtatacag tactgtggga 1380
acatcacaga ttttggctcc atgccctaaa gagaaattgg ctttcagatt atttggatta 1440
aaaacaaaga ctttcttaag agatgtaaaa ttttcatgat gttttctttt ttgctaaaac 1500
taaagaatta ttcttttaca tttcagtgtt cctggaccac gagaacgcca acaagatcct 1560
gaacagaccc aagagataca acagcggcaa gctggaagag ttcgtgcagg gcaacctgga 1620
acgcgagtgc atggaagaga agtgcagctt cgaagaggcc agagaggtgt tcgagaacac 1680
cgagagaacc accgagttct ggaagcagta cgtggacggc gaccagtgcg agagcaaccc 1740
ttgtctgaac ggcggcagct gcaaggacga catcaacagc tacgagtgct ggtgcccctt 1800
cggcttcgag ggcaagaact gcgagctgga cgtgacctgc aacatcaaga acggcagatg 1860
cgagcagttc tgcaagaaca gcgccgacaa caaggtcgtg tgctcctgca ccgagggcta 1920
cagactggcc gagaaccaga agtcctgcga gcccgctgtg cctttcccat gcggaagagt 1980
gtccgtgtcc cagaccagca agctgaccag agccgagaca gtgttccccg acgtggacta 2040
cgtgaacagc accgaggccg agacaatcct ggacaacatc acccagagca cccagtcctt 2100
caacgacttc accagagtcg tgggcggcga ggatgctaag cctggccagt tcccgtggca 2160
ggtggtgctg aacggaaagg tggacgcctt ctgcggcggc tccatcgtga acgagaagtg 2220
gatcgtgaca gccgcccact gcgtggaaac cggcgtgaag atcacagtgg tggccggcga 2280
gcacaacatc gaggaaaccg agcacacaga gcagaaaaga aacgtgatca ggatcatccc 2340
ccaccacaac tacaacgccg ccatcaacaa gtacaaccac gatatcgccc tgctggaact 2400
ggacgagccc ctggtgctga atagctacgt gacccccatc tgtatcgccg acaaagagta 2460
caccaacatc tttctgaagt tcggcagcgg ctacgtgtcc ggctggggca gagtgtttca 2520
caagggcaga tccgctctgg tgctgcagta cctgagagtg cctctggtgg acagagccac 2580
ctgtctgaga agcaccaagt tcaccatcta caacaacatg ttctgcgctg gcttccacga 2640
gggcggcaga gactcttgtc agggcgattc tggcggccct cacgtgacag aggtggaagg 2700
caccagcttt ctgaccggca tcatcagctg gggcgaggaa tgcgccatga aggggaagta 2760
cggcatctac accaaggtgt ccagatacgt gaactggatc aaagaaaaga ccaagctgac 2820
ataa                                                              2824

<210> 463
<211> 2824
<212> DNA
<213> Artificial Sequence

<220> 
<223> FIXss-Pro-mini Intron-Pro-human FIX
      R318Y/R338E/T343R mouse optimized

<400> 463
atgcagcgcg tgaacatgat tatggccgag agccctggcc tgatcaccat ctgcctgctg 60
ggctacctgc tgagcgccga gtgtacaggt ttgtttcctt ttttaaaata cattgagtat 120
gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat 180
gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactggttc 240
tttgttagct aggttttctt cttcttcatt tttaaaacta aatagatcga caatgcttat 300
gatgcattta tgtttaataa acactgttca gttcatgatt tggtcatgta attcctgtta 360
gaaaacattc atctccttgg tttaaaaaaa ttaaaagtgg gaaaacaaag aaatagcaga 420
atatagtgaa aaaaaataac cacattattt ttgtttggac ttaccacttt gaaatcaaaa 480
tgggaaacaa aagcacaaac aatggcctta tttacacaaa aagtctgatt ttaagatata 540
tgacatttca aggtttcaga agtatgtaat gaggtgtgtc tctaattttt taaattatat 600
atcttcaatt taaagtttta gttaaaacat aaagattaac ctttcattag caagctgtta 660
gttatcacca aagcttttca tggattagga aaaaatcatt ttgtctctat gtcaaacatc 720
ttggagttga tatttgggga aacacaatac tcagttgagt tccctagggg agaaaagcaa 780
gcttaagaat tgacataaag agtaggaagt tagctaatgc aacatatatc actttgtttt 840
ttcacaacta cagtgacttt atgtatttcc cagaggaagg catacaggga agaaattatc 900
ccatttggac aaacagcatg ttctcacagg aagcatttat cacacttact tgtcaacttt 960
ctagaatcaa atctagtagc tgacagtacc aggatcaggg gtgccaaccc taagcacccc 1020
cagaaagctg actggccctg tggttcccac tccagacatg atgtcagctg tgaaatcgac 1080
gtcgctggac cataattagg cttctgttct tcaggagaca tttgttcaaa gtcatttggg 1140
caaccatatt ctgaaaacag cccagccagg gtgatggatc actttgcaaa gatcctcaat 1200
gagctatttt caagtgatga caaagtgtga agttaaccgc tcatttgaga actttctttt 1260
tcatccaaag taaattcaaa tatgattaga aatctgacct tttattactg gaattctctt 1320
gactaaaagt aaaattgaat tttaattcct aaatctccat gtgtatacag tactgtggga 1380
acatcacaga ttttggctcc atgccctaaa gagaaattgg ctttcagatt atttggatta 1440
aaaacaaaga ctttcttaag agatgtaaaa ttttcatgat gttttctttt ttgctaaaac 1500
taaagaatta ttcttttaca tttcagtgtt cctggaccac gagaacgcca acaagatcct 1560
gaacagaccc aagagataca acagcggcaa gctggaagag ttcgtgcagg gcaacctgga 1620
acgcgagtgc atggaagaga agtgcagctt cgaagaggcc agagaggtgt tcgagaacac 1680
cgagagaacc accgagttct ggaagcagta cgtggacggc gaccagtgcg agagcaaccc 1740
ttgtctgaac ggcggcagct gcaaggacga catcaacagc tacgagtgct ggtgcccctt 1800
cggcttcgag ggcaagaact gcgagctgga cgtgacctgc aacatcaaga acggcagatg 1860
cgagcagttc tgcaagaaca gcgccgacaa caaggtcgtg tgctcctgca ccgagggcta 1920
cagactggcc gagaaccaga agtcctgcga gcccgctgtg cctttcccat gcggaagagt 1980
gtccgtgtcc cagaccagca agctgaccag agccgagaca gtgttccccg acgtggacta 2040
cgtgaacagc accgaggccg agacaatcct ggacaacatc acccagagca cccagtcctt 2100
caacgacttc accagagtcg tgggcggcga ggatgctaag cctggccagt tcccgtggca 2160
ggtggtgctg aacggaaagg tggacgcctt ctgcggcggc tccatcgtga acgagaagtg 2220
gatcgtgaca gccgcccact gcgtggaaac cggcgtgaag atcacagtgg tggccggcga 2280
gcacaacatc gaggaaaccg agcacacaga gcagaaaaga aacgtgatca ggatcatccc 2340
ccaccacaac tacaacgccg ccatcaacaa gtacaaccac gatatcgccc tgctggaact 2400
ggacgagccc ctggtgctga atagctacgt gacccccatc tgtatcgccg acaaagagta 2460
caccaacatc tttctgaagt tcggcagcgg ctacgtgtcc ggctggggca gagtgtttca 2520
caagggctac tccgctctgg tgctgcagta cctgagagtg cctctggtgg acagagccac 2580
ctgtctggaa agcaccaagt tcagaatcta caacaacatg ttctgcgctg gcttccacga 2640
gggcggcaga gactcttgtc agggcgattc tggcggccct cacgtgacag aggtggaagg 2700
caccagcttt ctgaccggca tcatcagctg gggcgaggaa tgcgccatga aggggaagta 2760
cggcatctac accaaggtgt ccagatacgt gaactggatc aaagaaaaga ccaagctgac 2820
ataa                                                              2824

<210> 464
<211> 2824
<212> DNA
<213> Artificial Sequence

<220> 
<223> FIXss-Pro-mini Intron-Pro-human FIX R338L mouse
      optimized

<400> 464
atgcagcgcg tgaacatgat tatggccgag agccctggcc tgatcaccat ctgcctgctg 60
ggctacctgc tgagcgccga gtgtacaggt ttgtttcctt ttttaaaata cattgagtat 120
gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat 180
gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactggttc 240
tttgttagct aggttttctt cttcttcatt tttaaaacta aatagatcga caatgcttat 300
gatgcattta tgtttaataa acactgttca gttcatgatt tggtcatgta attcctgtta 360
gaaaacattc atctccttgg tttaaaaaaa ttaaaagtgg gaaaacaaag aaatagcaga 420
atatagtgaa aaaaaataac cacattattt ttgtttggac ttaccacttt gaaatcaaaa 480
tgggaaacaa aagcacaaac aatggcctta tttacacaaa aagtctgatt ttaagatata 540
tgacatttca aggtttcaga agtatgtaat gaggtgtgtc tctaattttt taaattatat 600
atcttcaatt taaagtttta gttaaaacat aaagattaac ctttcattag caagctgtta 660
gttatcacca aagcttttca tggattagga aaaaatcatt ttgtctctat gtcaaacatc 720
ttggagttga tatttgggga aacacaatac tcagttgagt tccctagggg agaaaagcaa 780
gcttaagaat tgacataaag agtaggaagt tagctaatgc aacatatatc actttgtttt 840
ttcacaacta cagtgacttt atgtatttcc cagaggaagg catacaggga agaaattatc 900
ccatttggac aaacagcatg ttctcacagg aagcatttat cacacttact tgtcaacttt 960
ctagaatcaa atctagtagc tgacagtacc aggatcaggg gtgccaaccc taagcacccc 1020
cagaaagctg actggccctg tggttcccac tccagacatg atgtcagctg tgaaatcgac 1080
gtcgctggac cataattagg cttctgttct tcaggagaca tttgttcaaa gtcatttggg 1140
caaccatatt ctgaaaacag cccagccagg gtgatggatc actttgcaaa gatcctcaat 1200
gagctatttt caagtgatga caaagtgtga agttaaccgc tcatttgaga actttctttt 1260
tcatccaaag taaattcaaa tatgattaga aatctgacct tttattactg gaattctctt 1320
gactaaaagt aaaattgaat tttaattcct aaatctccat gtgtatacag tactgtggga 1380
acatcacaga ttttggctcc atgccctaaa gagaaattgg ctttcagatt atttggatta 1440
aaaacaaaga ctttcttaag agatgtaaaa ttttcatgat gttttctttt ttgctaaaac 1500
taaagaatta ttcttttaca tttcagtgtt cctggaccac gagaacgcca acaagatcct 1560
gaacagaccc aagagataca acagcggcaa gctggaagag ttcgtgcagg gcaacctgga 1620
acgcgagtgc atggaagaga agtgcagctt cgaagaggcc agagaggtgt tcgagaacac 1680
cgagagaacc accgagttct ggaagcagta cgtggacggc gaccagtgcg agagcaaccc 1740
ttgtctgaac ggcggcagct gcaaggacga catcaacagc tacgagtgct ggtgcccctt 1800
cggcttcgag ggcaagaact gcgagctgga cgtgacctgc aacatcaaga acggcagatg 1860
cgagcagttc tgcaagaaca gcgccgacaa caaggtcgtg tgctcctgca ccgagggcta 1920
cagactggcc gagaaccaga agtcctgcga gcccgctgtg cctttcccat gcggaagagt 1980
gtccgtgtcc cagaccagca agctgaccag agccgagaca gtgttccccg acgtggacta 2040
cgtgaacagc accgaggccg agacaatcct ggacaacatc acccagagca cccagtcctt 2100
caacgacttc accagagtcg tgggcggcga ggatgctaag cctggccagt tcccgtggca 2160
ggtggtgctg aacggaaagg tggacgcctt ctgcggcggc tccatcgtga acgagaagtg 2220
gatcgtgaca gccgcccact gcgtggaaac cggcgtgaag atcacagtgg tggccggcga 2280
gcacaacatc gaggaaaccg agcacacaga gcagaaaaga aacgtgatca ggatcatccc 2340
ccaccacaac tacaacgccg ccatcaacaa gtacaaccac gatatcgccc tgctggaact 2400
ggacgagccc ctggtgctga atagctacgt gacccccatc tgtatcgccg acaaagagta 2460
caccaacatc tttctgaagt tcggcagcgg ctacgtgtcc ggctggggca gagtgtttca 2520
caagggcaga tccgctctgg tgctgcagta cctgagagtg cctctggtgg acagagccac 2580
ctgtctgctg agcaccaagt tcaccatcta caacaacatg ttctgcgctg gcttccacga 2640
gggcggcaga gactcttgtc agggcgattc tggcggccct cacgtgacag aggtggaagg 2700
caccagcttt ctgaccggca tcatcagctg gggcgaggaa tgcgccatga aggggaagta 2760
cggcatctac accaaggtgt ccagatacgt gaactggatc aaagaaaaga ccaagctgac 2820
ataa                                                              2824

<210> 465
<211> 2821
<212> DNA
<213> Artificial Sequence

<220> 
<223> FIXss-Pro-mini Intron-Pro-human wild-type FIX

<400> 465
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta 60
ggatatctac tcagtgctga atgtacaggt ttgtttcctt ttttaaaata cattgagtat 120
gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat 180
gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactggttc 240
tttgttagct aggttttctt cttcttcatt tttaaaacta aatagatcga caatgcttat 300
gatgcattta tgtttaataa acactgttca gttcatgatt tggtcatgta attcctgtta 360
gaaaacattc atctccttgg tttaaaaaaa ttaaaagtgg gaaaacaaag aaatagcaga 420
atatagtgaa aaaaaataac cacattattt ttgtttggac ttaccacttt gaaatcaaaa 480
tgggaaacaa aagcacaaac aatggcctta tttacacaaa aagtctgatt ttaagatata 540
tgacatttca aggtttcaga agtatgtaat gaggtgtgtc tctaattttt taaattatat 600
atcttcaatt taaagtttta gttaaaacat aaagattaac ctttcattag caagctgtta 660
gttatcacca aagcttttca tggattagga aaaaatcatt ttgtctctat gtcaaacatc 720
ttggagttga tatttgggga aacacaatac tcagttgagt tccctagggg agaaaagcaa 780
gcttaagaat tgacataaag agtaggaagt tagctaatgc aacatatatc actttgtttt 840
ttcacaacta cagtgacttt atgtatttcc cagaggaagg catacaggga agaaattatc 900
ccatttggac aaacagcatg ttctcacagg aagcatttat cacacttact tgtcaacttt 960
ctagaatcaa atctagtagc tgacagtacc aggatcaggg gtgccaaccc taagcacccc 1020
cagaaagctg actggccctg tggttcccac tccagacatg atgtcagctg tgaaatcgac 1080
gtcgctggac cataattagg cttctgttct tcaggagaca tttgttcaaa gtcatttggg 1140
caaccatatt ctgaaaacag cccagccagg gtgatggatc actttgcaaa gatcctcaat 1200
gagctatttt caagtgatga caaagtgtga agttaaccgc tcatttgaga actttctttt 1260
tcatccaaag taaattcaaa tatgattaga aatctgacct tttattactg gaattctctt 1320
gactaaaagt aaaattgaat tttaattcct aaatctccat gtgtatacag tactgtggga 1380
acatcacaga ttttggctcc atgccctaaa gagaaattgg ctttcagatt atttggatta 1440
aaaacaaaga ctttcttaag agatgtaaaa ttttcatgat gttttctttt ttgctaaaac 1500
taaagaatta ttcttttaca tttcagtttt tcttgatcat gaaaacgcca acaaaattct 1560
gaatcggcca aagaggtata attcaggtaa attggaagag tttgttcaag ggaaccttga 1620
gagagaatgt atggaagaaa agtgtagttt tgaagaagca cgagaagttt ttgaaaacac 1680
tgaaagaaca actgaatttt ggaagcagta tgttgatgga gatcagtgtg agtccaatcc 1740
atgtttaaat ggcggcagtt gcaaggatga cattaattcc tatgaatgtt ggtgtccctt 1800
tggatttgaa ggaaagaact gtgaattaga tgtaacatgt aacattaaga atggcagatg 1860
cgagcagttt tgtaaaaata gtgctgataa caaggtggtt tgctcctgta ctgagggata 1920
tcgacttgca gaaaaccaga agtcctgtga accagcagtg ccatttccat gtggaagagt 1980
ttctgtttca caaacttcta agctcacccg tgctgagact gtttttcctg atgtggacta 2040
tgtaaattct actgaagctg aaaccatttt ggataacatc actcaaagca cccaatcatt 2100
taatgacttc actcgggttg ttggtggaga agatgccaaa ccaggtcaat tcccttggca 2160
ggttgttttg aatggtaaag ttgatgcatt ctgtggaggc tctatcgtta atgaaaaatg 2220
gattgtaact gctgcccact gtgttgaaac tggtgttaaa attacagttg tcgcaggtga 2280
acataatatt gaggagacag aacatacaga gcaaaagcga aatgtgattc gaattattcc 2340
tcaccacaac tacaatgcag ctattaataa gtacaaccat gacattgccc ttctggaact 2400
ggacgaaccc ttagtgctaa acagctacgt tacacctatt tgcattgctg acaaggaata 2460
cacgaacatc ttcctcaaat ttggatctgg ctatgtaagt ggctggggaa gagtcttcca 2520
caaagggaga tcagctttag ttcttcagta ccttagagtt ccacttgttg accgagccac 2580
atgtcttcga tctacaaagt tcaccatcta taacaacatg ttctgtgctg gcttccatga 2640
aggaggtaga gattcatgtc aaggagatag tgggggaccc catgttactg aagtggaagg 2700
gaccagtttc ttaactggaa ttattagctg gggtgaagag tgtgcaatga aaggcaaata 2760
tggaatatat accaaggtat cccggtatgt caactggatt aaggaaaaaa caaagctcac 2820
t                                                                 2821

<210> 466
<211> 2821
<212> DNA
<213> Artificial Sequence

<220> 
<223> FIXss-Pro-mini Intron-Pro-human FIX
      R318Y/R338E/T343R

<400> 466
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta 60
ggatatctac tcagtgctga atgtacaggt ttgtttcctt ttttaaaata cattgagtat 120
gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat 180
gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactggttc 240
tttgttagct aggttttctt cttcttcatt tttaaaacta aatagatcga caatgcttat 300
gatgcattta tgtttaataa acactgttca gttcatgatt tggtcatgta attcctgtta 360
gaaaacattc atctccttgg tttaaaaaaa ttaaaagtgg gaaaacaaag aaatagcaga 420
atatagtgaa aaaaaataac cacattattt ttgtttggac ttaccacttt gaaatcaaaa 480
tgggaaacaa aagcacaaac aatggcctta tttacacaaa aagtctgatt ttaagatata 540
tgacatttca aggtttcaga agtatgtaat gaggtgtgtc tctaattttt taaattatat 600
atcttcaatt taaagtttta gttaaaacat aaagattaac ctttcattag caagctgtta 660
gttatcacca aagcttttca tggattagga aaaaatcatt ttgtctctat gtcaaacatc 720
ttggagttga tatttgggga aacacaatac tcagttgagt tccctagggg agaaaagcaa 780
gcttaagaat tgacataaag agtaggaagt tagctaatgc aacatatatc actttgtttt 840
ttcacaacta cagtgacttt atgtatttcc cagaggaagg catacaggga agaaattatc 900
ccatttggac aaacagcatg ttctcacagg aagcatttat cacacttact tgtcaacttt 960
ctagaatcaa atctagtagc tgacagtacc aggatcaggg gtgccaaccc taagcacccc 1020
cagaaagctg actggccctg tggttcccac tccagacatg atgtcagctg tgaaatcgac 1080
gtcgctggac cataattagg cttctgttct tcaggagaca tttgttcaaa gtcatttggg 1140
caaccatatt ctgaaaacag cccagccagg gtgatggatc actttgcaaa gatcctcaat 1200
gagctatttt caagtgatga caaagtgtga agttaaccgc tcatttgaga actttctttt 1260
tcatccaaag taaattcaaa tatgattaga aatctgacct tttattactg gaattctctt 1320
gactaaaagt aaaattgaat tttaattcct aaatctccat gtgtatacag tactgtggga 1380
acatcacaga ttttggctcc atgccctaaa gagaaattgg ctttcagatt atttggatta 1440
aaaacaaaga ctttcttaag agatgtaaaa ttttcatgat gttttctttt ttgctaaaac 1500
taaagaatta ttcttttaca tttcagtttt tcttgatcat gaaaacgcca acaaaattct 1560
gaatcggcca aagaggtata attcaggtaa attggaagag tttgttcaag ggaaccttga 1620
gagagaatgt atggaagaaa agtgtagttt tgaagaagca cgagaagttt ttgaaaacac 1680
tgaaagaaca actgaatttt ggaagcagta tgttgatgga gatcagtgtg agtccaatcc 1740
atgtttaaat ggcggcagtt gcaaggatga cattaattcc tatgaatgtt ggtgtccctt 1800
tggatttgaa ggaaagaact gtgaattaga tgtaacatgt aacattaaga atggcagatg 1860
cgagcagttt tgtaaaaata gtgctgataa caaggtggtt tgctcctgta ctgagggata 1920
tcgacttgca gaaaaccaga agtcctgtga accagcagtg ccatttccat gtggaagagt 1980
ttctgtttca caaacttcta agctcacccg tgctgagact gtttttcctg atgtggacta 2040
tgtaaattct actgaagctg aaaccatttt ggataacatc actcaaagca cccaatcatt 2100
taatgacttc actcgggttg ttggtggaga agatgccaaa ccaggtcaat tcccttggca 2160
ggttgttttg aatggtaaag ttgatgcatt ctgtggaggc tctatcgtta atgaaaaatg 2220
gattgtaact gctgcccact gtgttgaaac tggtgttaaa attacagttg tcgcaggtga 2280
acataatatt gaggagacag aacatacaga gcaaaagcga aatgtgattc gaattattcc 2340
tcaccacaac tacaatgcag ctattaataa gtacaaccat gacattgccc ttctggaact 2400
ggacgaaccc ttagtgctaa acagctacgt tacacctatt tgcattgctg acaaggaata 2460
cacgaacatc ttcctcaaat ttggatctgg ctatgtaagt ggctggggaa gagtcttcca 2520
caaagggaga tcagctttag ttcttcagta ccttagagtt ccacttgttg accgagccac 2580
atgtcttcga tctacaaagt tcaccatcta taacaacatg ttctgtgctg gcttccatga 2640
aggaggtaga gattcatgtc aaggagatag tgggggaccc catgttactg aagtggaagg 2700
gaccagtttc ttaactggaa ttattagctg gggtgaagag tgtgcaatga aaggcaaata 2760
tggaatatat accaaggtat cccggtatgt caactggatt aaggaaaaaa caaagctcac 2820
t                                                                 2821

<210> 467
<211> 2821
<212> DNA
<213> Artificial Sequence

<220> 
<223> FIXss-Pro-mini Intron-Pro-human FIX R338L

<400> 467
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta 60
ggatatctac tcagtgctga atgtacaggt ttgtttcctt ttttaaaata cattgagtat 120
gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat 180
gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactggttc 240
tttgttagct aggttttctt cttcttcatt tttaaaacta aatagatcga caatgcttat 300
gatgcattta tgtttaataa acactgttca gttcatgatt tggtcatgta attcctgtta 360
gaaaacattc atctccttgg tttaaaaaaa ttaaaagtgg gaaaacaaag aaatagcaga 420
atatagtgaa aaaaaataac cacattattt ttgtttggac ttaccacttt gaaatcaaaa 480
tgggaaacaa aagcacaaac aatggcctta tttacacaaa aagtctgatt ttaagatata 540
tgacatttca aggtttcaga agtatgtaat gaggtgtgtc tctaattttt taaattatat 600
atcttcaatt taaagtttta gttaaaacat aaagattaac ctttcattag caagctgtta 660
gttatcacca aagcttttca tggattagga aaaaatcatt ttgtctctat gtcaaacatc 720
ttggagttga tatttgggga aacacaatac tcagttgagt tccctagggg agaaaagcaa 780
gcttaagaat tgacataaag agtaggaagt tagctaatgc aacatatatc actttgtttt 840
ttcacaacta cagtgacttt atgtatttcc cagaggaagg catacaggga agaaattatc 900
ccatttggac aaacagcatg ttctcacagg aagcatttat cacacttact tgtcaacttt 960
ctagaatcaa atctagtagc tgacagtacc aggatcaggg gtgccaaccc taagcacccc 1020
cagaaagctg actggccctg tggttcccac tccagacatg atgtcagctg tgaaatcgac 1080
gtcgctggac cataattagg cttctgttct tcaggagaca tttgttcaaa gtcatttggg 1140
caaccatatt ctgaaaacag cccagccagg gtgatggatc actttgcaaa gatcctcaat 1200
gagctatttt caagtgatga caaagtgtga agttaaccgc tcatttgaga actttctttt 1260
tcatccaaag taaattcaaa tatgattaga aatctgacct tttattactg gaattctctt 1320
gactaaaagt aaaattgaat tttaattcct aaatctccat gtgtatacag tactgtggga 1380
acatcacaga ttttggctcc atgccctaaa gagaaattgg ctttcagatt atttggatta 1440
aaaacaaaga ctttcttaag agatgtaaaa ttttcatgat gttttctttt ttgctaaaac 1500
taaagaatta ttcttttaca tttcagtttt tcttgatcat gaaaacgcca acaaaattct 1560
gaatcggcca aagaggtata attcaggtaa attggaagag tttgttcaag ggaaccttga 1620
gagagaatgt atggaagaaa agtgtagttt tgaagaagca cgagaagttt ttgaaaacac 1680
tgaaagaaca actgaatttt ggaagcagta tgttgatgga gatcagtgtg agtccaatcc 1740
atgtttaaat ggcggcagtt gcaaggatga cattaattcc tatgaatgtt ggtgtccctt 1800
tggatttgaa ggaaagaact gtgaattaga tgtaacatgt aacattaaga atggcagatg 1860
cgagcagttt tgtaaaaata gtgctgataa caaggtggtt tgctcctgta ctgagggata 1920
tcgacttgca gaaaaccaga agtcctgtga accagcagtg ccatttccat gtggaagagt 1980
ttctgtttca caaacttcta agctcacccg tgctgagact gtttttcctg atgtggacta 2040
tgtaaattct actgaagctg aaaccatttt ggataacatc actcaaagca cccaatcatt 2100
taatgacttc actcgggttg ttggtggaga agatgccaaa ccaggtcaat tcccttggca 2160
ggttgttttg aatggtaaag ttgatgcatt ctgtggaggc tctatcgtta atgaaaaatg 2220
gattgtaact gctgcccact gtgttgaaac tggtgttaaa attacagttg tcgcaggtga 2280
acataatatt gaggagacag aacatacaga gcaaaagcga aatgtgattc gaattattcc 2340
tcaccacaac tacaatgcag ctattaataa gtacaaccat gacattgccc ttctggaact 2400
ggacgaaccc ttagtgctaa acagctacgt tacacctatt tgcattgctg acaaggaata 2460
cacgaacatc ttcctcaaat ttggatctgg ctatgtaagt ggctggggaa gagtcttcca 2520
caaagggaga tcagctttag ttcttcagta ccttagagtt ccacttgttg accgagccac 2580
atgtcttctg tctacaaagt tcaccatcta taacaacatg ttctgtgctg gcttccatga 2640
aggaggtaga gattcatgtc aaggagatag tgggggaccc catgttactg aagtggaagg 2700
gaccagtttc ttaactggaa ttattagctg gggtgaagag tgtgcaatga aaggcaaata 2760
tggaatatat accaaggtat cccggtatgt caactggatt aaggaaaaaa caaagctcac 2820
t                                                                 2821

<210> 468
<211> 1383
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX R318Y/R338E/T343R precursor

<400> 468
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta 60
ggatatctac tcagtgctga atgtacagtt tttcttgatc atgaaaacgc caacaaaatt 120
ctgaatcggc caaagaggta taattcaggt aaattggaag agtttgttca agggaacctt 180
gagagagaat gtatggaaga aaagtgtagt tttgaagaag cacgagaagt ttttgaaaac 240
actgaaagaa caactgaatt ttggaagcag tatgttgatg gagatcagtg tgagtccaat 300
ccatgtttaa atggcggcag ttgcaaggat gacattaatt cctatgaatg ttggtgtccc 360
tttggatttg aaggaaagaa ctgtgaatta gatgtaacat gtaacattaa gaatggcaga 420
tgcgagcagt tttgtaaaaa tagtgctgat aacaaggtgg tttgctcctg tactgaggga 480
tatcgacttg cagaaaacca gaagtcctgt gaaccagcag tgccatttcc atgtggaaga 540
gtttctgttt cacaaacttc taagctcacc cgtgctgaga ctgtttttcc tgatgtggac 600
tatgtaaatt ctactgaagc tgaaaccatt ttggataaca tcactcaaag cacccaatca 660
tttaatgact tcactcgggt tgttggtgga gaagatgcca aaccaggtca attcccttgg 720
caggttgttt tgaatggtaa agttgatgca ttctgtggag gctctatcgt taatgaaaaa 780
tggattgtaa ctgctgccca ctgtgttgaa actggtgtta aaattacagt tgtcgcaggt 840
gaacataata ttgaggagac agaacataca gagcaaaagc gaaatgtgat tcgaattatt 900
cctcaccaca actacaatgc agctattaat aagtacaacc atgacattgc ccttctggaa 960
ctggacgaac ccttagtgct aaacagctac gttacaccta tttgcattgc tgacaaggaa 1020
tacacgaaca tcttcctcaa atttggatct ggctatgtaa gtggctgggg aagagtcttc 1080
cacaaagggt actcagcttt agttcttcag taccttagag ttccacttgt tgaccgagcc 1140
acatgtcttg aatctacaaa gttcaggatc tataacaaca tgttctgtgc tggcttccat 1200
gaaggaggta gagattcatg tcaaggagat agtgggggac cccatgttac tgaagtggaa 1260
gggaccagtt tcttaactgg aattattagc tggggtgaag agtgtgcaat gaaaggcaaa 1320
tatggaatat ataccaaggt atcccggtat gtcaactgga ttaaggaaaa aacaaagctc 1380
act                                                               1383

<210> 469
<211> 1383
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX R338L precursor

<400> 469
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta 60
ggatatctac tcagtgctga atgtacagtt tttcttgatc atgaaaacgc caacaaaatt 120
ctgaatcggc caaagaggta taattcaggt aaattggaag agtttgttca agggaacctt 180
gagagagaat gtatggaaga aaagtgtagt tttgaagaag cacgagaagt ttttgaaaac 240
actgaaagaa caactgaatt ttggaagcag tatgttgatg gagatcagtg tgagtccaat 300
ccatgtttaa atggcggcag ttgcaaggat gacattaatt cctatgaatg ttggtgtccc 360
tttggatttg aaggaaagaa ctgtgaatta gatgtaacat gtaacattaa gaatggcaga 420
tgcgagcagt tttgtaaaaa tagtgctgat aacaaggtgg tttgctcctg tactgaggga 480
tatcgacttg cagaaaacca gaagtcctgt gaaccagcag tgccatttcc atgtggaaga 540
gtttctgttt cacaaacttc taagctcacc cgtgctgaga ctgtttttcc tgatgtggac 600
tatgtaaatt ctactgaagc tgaaaccatt ttggataaca tcactcaaag cacccaatca 660
tttaatgact tcactcgggt tgttggtgga gaagatgcca aaccaggtca attcccttgg 720
caggttgttt tgaatggtaa agttgatgca ttctgtggag gctctatcgt taatgaaaaa 780
tggattgtaa ctgctgccca ctgtgttgaa actggtgtta aaattacagt tgtcgcaggt 840
gaacataata ttgaggagac agaacataca gagcaaaagc gaaatgtgat tcgaattatt 900
cctcaccaca actacaatgc agctattaat aagtacaacc atgacattgc ccttctggaa 960
ctggacgaac ccttagtgct aaacagctac gttacaccta tttgcattgc tgacaaggaa 1020
tacacgaaca tcttcctcaa atttggatct ggctatgtaa gtggctgggg aagagtcttc 1080
cacaaaggga gatcagcttt agttcttcag taccttagag ttccacttgt tgaccgagcc 1140
acatgtcttc tgtctacaaa gttcaccatc tataacaaca tgttctgtgc tggcttccat 1200
gaaggaggta gagattcatg tcaaggagat agtgggggac cccatgttac tgaagtggaa 1260
gggaccagtt tcttaactgg aattattagc tggggtgaag agtgtgcaat gaaaggcaaa 1320
tatggaatat ataccaaggt atcccggtat gtcaactgga ttaaggaaaa aacaaagctc 1380
act                                                               1383

<210> 470
<211> 461
<212> PRT
<213> Artificial Sequence

<220> 
<223> human FIX R318Y/R338E/T343R precursor

<400> 470
Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr
 1               5                  10                  15      
Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu
            20                  25                  30          
Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn
        35                  40                  45              
Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys
    50                  55                  60                  
Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn
65                  70                  75                  80  
Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln
                85                  90                  95      
Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile
            100                 105                 110         
Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys
        115                 120                 125             
Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe
    130                 135                 140                 
Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly
145                 150                 155                 160 
Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe
                165                 170                 175     
Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala
            180                 185                 190         
Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu
        195                 200                 205             
Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe
    210                 215                 220                 
Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp
225                 230                 235                 240 
Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile
                245                 250                 255     
Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly
            260                 265                 270         
Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu
        275                 280                 285             
His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn
    290                 295                 300                 
Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu
305                 310                 315                 320 
Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile
                325                 330                 335     
Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr
            340                 345                 350         
Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala Leu Val
        355                 360                 365             
Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Glu
    370                 375                 380                 
Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His
385                 390                 395                 400 
Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val
                405                 410                 415     
Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly
            420                 425                 430         
Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser
        435                 440                 445             
Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
    450                 455                 460     


<210> 471
<211> 461
<212> PRT
<213> Artificial Sequence

<220> 
<223> human FIX R338L precursor

<400> 471
Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr
 1               5                  10                  15      
Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu
            20                  25                  30          
Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn
        35                  40                  45              
Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys
    50                  55                  60                  
Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn
65                  70                  75                  80  
Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln
                85                  90                  95      
Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile
            100                 105                 110         
Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys
        115                 120                 125             
Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe
    130                 135                 140                 
Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly
145                 150                 155                 160 
Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe
                165                 170                 175     
Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala
            180                 185                 190         
Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu
        195                 200                 205             
Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe
    210                 215                 220                 
Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp
225                 230                 235                 240 
Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile
                245                 250                 255     
Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly
            260                 265                 270         
Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu
        275                 280                 285             
His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn
    290                 295                 300                 
Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu
305                 310                 315                 320 
Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile
                325                 330                 335     
Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr
            340                 345                 350         
Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val
        355                 360                 365             
Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Leu
    370                 375                 380                 
Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His
385                 390                 395                 400 
Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val
                405                 410                 415     
Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly
            420                 425                 430         
Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser
        435                 440                 445             
Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
    450                 455                 460     


<210> 472
<211> 1296
<212> DNA
<213> Artificial Sequence

<220> 
<223> human wild type FIX propeptide-mature

<400> 472
gtttttcttg atcatgaaaa cgccaacaaa attctgaatc ggccaaagag gtataattca 60
ggtaaattgg aagagtttgt tcaagggaac cttgagagag aatgtatgga agaaaagtgt 120
agttttgaag aagcacgaga agtttttgaa aacactgaaa gaacaactga attttggaag 180
cagtatgttg atggagatca gtgtgagtcc aatccatgtt taaatggcgg cagttgcaag 240
gatgacatta attcctatga atgttggtgt ccctttggat ttgaaggaaa gaactgtgaa 300
ttagatgtaa catgtaacat taagaatggc agatgcgagc agttttgtaa aaatagtgct 360
gataacaagg tggtttgctc ctgtactgag ggatatcgac ttgcagaaaa ccagaagtcc 420
tgtgaaccag cagtgccatt tccatgtgga agagtttctg tttcacaaac ttctaagctc 480
acccgtgctg agactgtttt tcctgatgtg gactatgtaa attctactga agctgaaacc 540
attttggata acatcactca aagcacccaa tcatttaatg acttcactcg ggttgttggt 600
ggagaagatg ccaaaccagg tcaattccct tggcaggttg ttttgaatgg taaagttgat 660
gcattctgtg gaggctctat cgttaatgaa aaatggattg taactgctgc ccactgtgtt 720
gaaactggtg ttaaaattac agttgtcgca ggtgaacata atattgagga gacagaacat 780
acagagcaaa agcgaaatgt gattcgaatt attcctcacc acaactacaa tgcagctatt 840
aataagtaca accatgacat tgcccttctg gaactggacg aacccttagt gctaaacagc 900
tacgttacac ctatttgcat tgctgacaag gaatacacga acatcttcct caaatttgga 960
tctggctatg taagtggctg gggaagagtc ttccacaaag ggagatcagc tttagttctt 1020
cagtacctta gagttccact tgttgaccga gccacatgtc ttcgatctac aaagttcacc 1080
atctataaca acatgttctg tgctggcttc catgaaggag gtagagattc atgtcaagga 1140
gatagtgggg gaccccatgt tactgaagtg gaagggacca gtttcttaac tggaattatt 1200
agctggggtg aagagtgtgc aatgaaaggc aaatatggaa tatataccaa ggtatcccgg 1260
tatgtcaact ggattaagga aaaaacaaag ctcact                           1296

<210> 473
<211> 1296
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX R318Y/R338E/T343R propeptide-mature

<400> 473
gtttttcttg atcatgaaaa cgccaacaaa attctgaatc ggccaaagag gtataattca 60
ggtaaattgg aagagtttgt tcaagggaac cttgagagag aatgtatgga agaaaagtgt 120
agttttgaag aagcacgaga agtttttgaa aacactgaaa gaacaactga attttggaag 180
cagtatgttg atggagatca gtgtgagtcc aatccatgtt taaatggcgg cagttgcaag 240
gatgacatta attcctatga atgttggtgt ccctttggat ttgaaggaaa gaactgtgaa 300
ttagatgtaa catgtaacat taagaatggc agatgcgagc agttttgtaa aaatagtgct 360
gataacaagg tggtttgctc ctgtactgag ggatatcgac ttgcagaaaa ccagaagtcc 420
tgtgaaccag cagtgccatt tccatgtgga agagtttctg tttcacaaac ttctaagctc 480
acccgtgctg agactgtttt tcctgatgtg gactatgtaa attctactga agctgaaacc 540
attttggata acatcactca aagcacccaa tcatttaatg acttcactcg ggttgttggt 600
ggagaagatg ccaaaccagg tcaattccct tggcaggttg ttttgaatgg taaagttgat 660
gcattctgtg gaggctctat cgttaatgaa aaatggattg taactgctgc ccactgtgtt 720
gaaactggtg ttaaaattac agttgtcgca ggtgaacata atattgagga gacagaacat 780
acagagcaaa agcgaaatgt gattcgaatt attcctcacc acaactacaa tgcagctatt 840
aataagtaca accatgacat tgcccttctg gaactggacg aacccttagt gctaaacagc 900
tacgttacac ctatttgcat tgctgacaag gaatacacga acatcttcct caaatttgga 960
tctggctatg taagtggctg gggaagagtc ttccacaaag ggtactcagc tttagttctt 1020
cagtacctta gagttccact tgttgaccga gccacatgtc ttgaatctac aaagttcagg 1080
atctataaca acatgttctg tgctggcttc catgaaggag gtagagattc atgtcaagga 1140
gatagtgggg gaccccatgt tactgaagtg gaagggacca gtttcttaac tggaattatt 1200
agctggggtg aagagtgtgc aatgaaaggc aaatatggaa tatataccaa ggtatcccgg 1260
tatgtcaact ggattaagga aaaaacaaag ctcact                           1296

<210> 474
<211> 1296
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX R338L propeptide-mature

<400> 474
gtttttcttg atcatgaaaa cgccaacaaa attctgaatc ggccaaagag gtataattca 60
ggtaaattgg aagagtttgt tcaagggaac cttgagagag aatgtatgga agaaaagtgt 120
agttttgaag aagcacgaga agtttttgaa aacactgaaa gaacaactga attttggaag 180
cagtatgttg atggagatca gtgtgagtcc aatccatgtt taaatggcgg cagttgcaag 240
gatgacatta attcctatga atgttggtgt ccctttggat ttgaaggaaa gaactgtgaa 300
ttagatgtaa catgtaacat taagaatggc agatgcgagc agttttgtaa aaatagtgct 360
gataacaagg tggtttgctc ctgtactgag ggatatcgac ttgcagaaaa ccagaagtcc 420
tgtgaaccag cagtgccatt tccatgtgga agagtttctg tttcacaaac ttctaagctc 480
acccgtgctg agactgtttt tcctgatgtg gactatgtaa attctactga agctgaaacc 540
attttggata acatcactca aagcacccaa tcatttaatg acttcactcg ggttgttggt 600
ggagaagatg ccaaaccagg tcaattccct tggcaggttg ttttgaatgg taaagttgat 660
gcattctgtg gaggctctat cgttaatgaa aaatggattg taactgctgc ccactgtgtt 720
gaaactggtg ttaaaattac agttgtcgca ggtgaacata atattgagga gacagaacat 780
acagagcaaa agcgaaatgt gattcgaatt attcctcacc acaactacaa tgcagctatt 840
aataagtaca accatgacat tgcccttctg gaactggacg aacccttagt gctaaacagc 900
tacgttacac ctatttgcat tgctgacaag gaatacacga acatcttcct caaatttgga 960
tctggctatg taagtggctg gggaagagtc ttccacaaag ggagatcagc tttagttctt 1020
cagtacctta gagttccact tgttgaccga gccacatgtc ttctgtctac aaagttcacc 1080
atctataaca acatgttctg tgctggcttc catgaaggag gtagagattc atgtcaagga 1140
gatagtgggg gaccccatgt tactgaagtg gaagggacca gtttcttaac tggaattatt 1200
agctggggtg aagagtgtgc aatgaaaggc aaatatggaa tatataccaa ggtatcccgg 1260
tatgtcaact ggattaagga aaaaacaaag ctcact                           1296

<210> 475
<211> 1296
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX T148A/R318Y/R338E/T343R
      propeptide-mature

<400> 475
gtttttcttg atcatgaaaa cgccaacaaa attctgaatc ggccaaagag gtataattca 60
ggtaaattgg aagagtttgt tcaagggaac cttgagagag aatgtatgga agaaaagtgt 120
agttttgaag aagcacgaga agtttttgaa aacactgaaa gaacaactga attttggaag 180
cagtatgttg atggagatca gtgtgagtcc aatccatgtt taaatggcgg cagttgcaag 240
gatgacatta attcctatga atgttggtgt ccctttggat ttgaaggaaa gaactgtgaa 300
ttagatgtaa catgtaacat taagaatggc agatgcgagc agttttgtaa aaatagtgct 360
gataacaagg tggtttgctc ctgtactgag ggatatcgac ttgcagaaaa ccagaagtcc 420
tgtgaaccag cagtgccatt tccatgtgga agagtttctg tttcacaaac ttctaagctc 480
acccgtgctg aggctgtttt tcctgatgtg gactatgtaa attctactga agctgaaacc 540
attttggata acatcactca aagcacccaa tcatttaatg acttcactcg ggttgttggt 600
ggagaagatg ccaaaccagg tcaattccct tggcaggttg ttttgaatgg taaagttgat 660
gcattctgtg gaggctctat cgttaatgaa aaatggattg taactgctgc ccactgtgtt 720
gaaactggtg ttaaaattac agttgtcgca ggtgaacata atattgagga gacagaacat 780
acagagcaaa agcgaaatgt gattcgaatt attcctcacc acaactacaa tgcagctatt 840
aataagtaca accatgacat tgcccttctg gaactggacg aacccttagt gctaaacagc 900
tacgttacac ctatttgcat tgctgacaag gaatacacga acatcttcct caaatttgga 960
tctggctatg taagtggctg gggaagagtc ttccacaaag ggtactcagc tttagttctt 1020
cagtacctta gagttccact tgttgaccga gccacatgtc ttgaatctac aaagttcagg 1080
atctataaca acatgttctg tgctggcttc catgaaggag gtagagattc atgtcaagga 1140
gatagtgggg gaccccatgt tactgaagtg gaagggacca gtttcttaac tggaattatt 1200
agctggggtg aagagtgtgc aatgaaaggc aaatatggaa tatataccaa ggtatcccgg 1260
tatgtcaact ggattaagga aaaaacaaag ctcact                           1296

<210> 476
<211> 1296
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX T148A/R338L propeptide-mature

<400> 476
gtttttcttg atcatgaaaa cgccaacaaa attctgaatc ggccaaagag gtataattca 60
ggtaaattgg aagagtttgt tcaagggaac cttgagagag aatgtatgga agaaaagtgt 120
agttttgaag aagcacgaga agtttttgaa aacactgaaa gaacaactga attttggaag 180
cagtatgttg atggagatca gtgtgagtcc aatccatgtt taaatggcgg cagttgcaag 240
gatgacatta attcctatga atgttggtgt ccctttggat ttgaaggaaa gaactgtgaa 300
ttagatgtaa catgtaacat taagaatggc agatgcgagc agttttgtaa aaatagtgct 360
gataacaagg tggtttgctc ctgtactgag ggatatcgac ttgcagaaaa ccagaagtcc 420
tgtgaaccag cagtgccatt tccatgtgga agagtttctg tttcacaaac ttctaagctc 480
acccgtgctg aggctgtttt tcctgatgtg gactatgtaa attctactga agctgaaacc 540
attttggata acatcactca aagcacccaa tcatttaatg acttcactcg ggttgttggt 600
ggagaagatg ccaaaccagg tcaattccct tggcaggttg ttttgaatgg taaagttgat 660
gcattctgtg gaggctctat cgttaatgaa aaatggattg taactgctgc ccactgtgtt 720
gaaactggtg ttaaaattac agttgtcgca ggtgaacata atattgagga gacagaacat 780
acagagcaaa agcgaaatgt gattcgaatt attcctcacc acaactacaa tgcagctatt 840
aataagtaca accatgacat tgcccttctg gaactggacg aacccttagt gctaaacagc 900
tacgttacac ctatttgcat tgctgacaag gaatacacga acatcttcct caaatttgga 960
tctggctatg taagtggctg gggaagagtc ttccacaaag ggagatcagc tttagttctt 1020
cagtacctta gagttccact tgttgaccga gccacatgtc ttctgtctac aaagttcacc 1080
atctataaca acatgttctg tgctggcttc catgaaggag gtagagattc atgtcaagga 1140
gatagtgggg gaccccatgt tactgaagtg gaagggacca gtttcttaac tggaattatt 1200
agctggggtg aagagtgtgc aatgaaaggc aaatatggaa tatataccaa ggtatcccgg 1260
tatgtcaact ggattaagga aaaaacaaag ctcact                           1296

<210> 477
<211> 432
<212> PRT
<213> Artificial Sequence

<220> 
<223> human wild type FIX propeptide-mature

<400> 477
Val Phe Leu Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys
 1               5                  10                  15      
Arg Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu
            20                  25                  30          
Arg Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val
        35                  40                  45              
Phe Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp
    50                  55                  60                  
Gly Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys
65                  70                  75                  80  
Asp Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly
                85                  90                  95      
Lys Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys
            100                 105                 110         
Glu Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys
        115                 120                 125             
Thr Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala
    130                 135                 140                 
Val Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu
145                 150                 155                 160 
Thr Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr
                165                 170                 175     
Glu Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe
            180                 185                 190         
Asn Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln
        195                 200                 205             
Phe Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly
    210                 215                 220                 
Gly Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val
225                 230                 235                 240 
Glu Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu
                245                 250                 255     
Glu Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro
            260                 265                 270         
His His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala
        275                 280                 285             
Leu Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro
    290                 295                 300                 
Ile Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly
305                 310                 315                 320 
Ser Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser
                325                 330                 335     
Ala Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr
            340                 345                 350         
Cys Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala
        355                 360                 365             
Gly Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly
    370                 375                 380                 
Pro His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile
385                 390                 395                 400 
Ser Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr
                405                 410                 415     
Lys Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
            420                 425                 430         


<210> 478
<211> 432
<212> PRT
<213> Artificial Sequence

<220> 
<223> human FIX R318Y/R338E/T343R propeptide-mature

<400> 478
Val Phe Leu Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys
 1               5                  10                  15      
Arg Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu
            20                  25                  30          
Arg Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val
        35                  40                  45              
Phe Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp
    50                  55                  60                  
Gly Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys
65                  70                  75                  80  
Asp Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly
                85                  90                  95      
Lys Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys
            100                 105                 110         
Glu Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys
        115                 120                 125             
Thr Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala
    130                 135                 140                 
Val Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu
145                 150                 155                 160 
Thr Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr
                165                 170                 175     
Glu Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe
            180                 185                 190         
Asn Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln
        195                 200                 205             
Phe Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly
    210                 215                 220                 
Gly Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val
225                 230                 235                 240 
Glu Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu
                245                 250                 255     
Glu Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro
            260                 265                 270         
His His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala
        275                 280                 285             
Leu Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro
    290                 295                 300                 
Ile Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly
305                 310                 315                 320 
Ser Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser
                325                 330                 335     
Ala Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr
            340                 345                 350         
Cys Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala
        355                 360                 365             
Gly Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly
    370                 375                 380                 
Pro His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile
385                 390                 395                 400 
Ser Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr
                405                 410                 415     
Lys Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
            420                 425                 430         


<210> 479
<211> 432
<212> PRT
<213> Artificial Sequence

<220> 
<223> human FIX R338L propeptide-mature

<400> 479
Val Phe Leu Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys
 1               5                  10                  15      
Arg Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu
            20                  25                  30          
Arg Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val
        35                  40                  45              
Phe Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp
    50                  55                  60                  
Gly Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys
65                  70                  75                  80  
Asp Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly
                85                  90                  95      
Lys Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys
            100                 105                 110         
Glu Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys
        115                 120                 125             
Thr Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala
    130                 135                 140                 
Val Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu
145                 150                 155                 160 
Thr Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr
                165                 170                 175     
Glu Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe
            180                 185                 190         
Asn Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln
        195                 200                 205             
Phe Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly
    210                 215                 220                 
Gly Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val
225                 230                 235                 240 
Glu Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu
                245                 250                 255     
Glu Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro
            260                 265                 270         
His His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala
        275                 280                 285             
Leu Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro
    290                 295                 300                 
Ile Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly
305                 310                 315                 320 
Ser Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser
                325                 330                 335     
Ala Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr
            340                 345                 350         
Cys Leu Leu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala
        355                 360                 365             
Gly Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly
    370                 375                 380                 
Pro His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile
385                 390                 395                 400 
Ser Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr
                405                 410                 415     
Lys Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
            420                 425                 430         


<210> 480
<211> 432
<212> PRT
<213> Artificial Sequence

<220> 
<223> human FIX T148A/R318Y/R338E/T343R
      propeptide-mature

<400> 480
Val Phe Leu Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys
 1               5                  10                  15      
Arg Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu
            20                  25                  30          
Arg Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val
        35                  40                  45              
Phe Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp
    50                  55                  60                  
Gly Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys
65                  70                  75                  80  
Asp Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly
                85                  90                  95      
Lys Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys
            100                 105                 110         
Glu Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys
        115                 120                 125             
Thr Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala
    130                 135                 140                 
Val Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu
145                 150                 155                 160 
Thr Arg Ala Glu Ala Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr
                165                 170                 175     
Glu Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe
            180                 185                 190         
Asn Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln
        195                 200                 205             
Phe Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly
    210                 215                 220                 
Gly Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val
225                 230                 235                 240 
Glu Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu
                245                 250                 255     
Glu Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro
            260                 265                 270         
His His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala
        275                 280                 285             
Leu Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro
    290                 295                 300                 
Ile Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly
305                 310                 315                 320 
Ser Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser
                325                 330                 335     
Ala Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr
            340                 345                 350         
Cys Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala
        355                 360                 365             
Gly Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly
    370                 375                 380                 
Pro His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile
385                 390                 395                 400 
Ser Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr
                405                 410                 415     
Lys Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
            420                 425                 430         


<210> 481
<211> 432
<212> PRT
<213> Artificial Sequence

<220> 
<223> human FIX T148A/R338L propeptide-mature

<400> 481
Val Phe Leu Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys
 1               5                  10                  15      
Arg Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu
            20                  25                  30          
Arg Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val
        35                  40                  45              
Phe Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp
    50                  55                  60                  
Gly Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys
65                  70                  75                  80  
Asp Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly
                85                  90                  95      
Lys Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys
            100                 105                 110         
Glu Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys
        115                 120                 125             
Thr Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala
    130                 135                 140                 
Val Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu
145                 150                 155                 160 
Thr Arg Ala Glu Ala Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr
                165                 170                 175     
Glu Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe
            180                 185                 190         
Asn Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln
        195                 200                 205             
Phe Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly
    210                 215                 220                 
Gly Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val
225                 230                 235                 240 
Glu Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu
                245                 250                 255     
Glu Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro
            260                 265                 270         
His His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala
        275                 280                 285             
Leu Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro
    290                 295                 300                 
Ile Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly
305                 310                 315                 320 
Ser Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser
                325                 330                 335     
Ala Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr
            340                 345                 350         
Cys Leu Leu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala
        355                 360                 365             
Gly Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly
    370                 375                 380                 
Pro His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile
385                 390                 395                 400 
Ser Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr
                405                 410                 415     
Lys Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
            420                 425                 430         


<210> 482
<211> 1245
<212> DNA
<213> Artificial Sequence

<220> 
<223> human WT FIX mature

<400> 482
tataattcag gtaaattgga agagtttgtt caagggaacc ttgagagaga atgtatggaa 60
gaaaagtgta gttttgaaga agcacgagaa gtttttgaaa acactgaaag aacaactgaa 120
ttttggaagc agtatgttga tggagatcag tgtgagtcca atccatgttt aaatggcggc 180
agttgcaagg atgacattaa ttcctatgaa tgttggtgtc cctttggatt tgaaggaaag 240
aactgtgaat tagatgtaac atgtaacatt aagaatggca gatgcgagca gttttgtaaa 300
aatagtgctg ataacaaggt ggtttgctcc tgtactgagg gatatcgact tgcagaaaac 360
cagaagtcct gtgaaccagc agtgccattt ccatgtggaa gagtttctgt ttcacaaact 420
tctaagctca cccgtgctga gactgttttt cctgatgtgg actatgtaaa ttctactgaa 480
gctgaaacca ttttggataa catcactcaa agcacccaat catttaatga cttcactcgg 540
gttgttggtg gagaagatgc caaaccaggt caattccctt ggcaggttgt tttgaatggt 600
aaagttgatg cattctgtgg aggctctatc gttaatgaaa aatggattgt aactgctgcc 660
cactgtgttg aaactggtgt taaaattaca gttgtcgcag gtgaacataa tattgaggag 720
acagaacata cagagcaaaa gcgaaatgtg attcgaatta ttcctcacca caactacaat 780
gcagctatta ataagtacaa ccatgacatt gcccttctgg aactggacga acccttagtg 840
ctaaacagct acgttacacc tatttgcatt gctgacaagg aatacacgaa catcttcctc 900
aaatttggat ctggctatgt aagtggctgg ggaagagtct tccacaaagg gagatcagct 960
ttagttcttc agtaccttag agttccactt gttgaccgag ccacatgtct tcgatctaca 1020
aagttcacca tctataacaa catgttctgt gctggcttcc atgaaggagg tagagattca 1080
tgtcaaggag atagtggggg accccatgtt actgaagtgg aagggaccag tttcttaact 1140
ggaattatta gctggggtga agagtgtgca atgaaaggca aatatggaat atataccaag 1200
gtatcccggt atgtcaactg gattaaggaa aaaacaaagc tcact                 1245

<210> 483
<211> 1245
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX R318Y/R338E/T343R mature

<400> 483
tataattcag gtaaattgga agagtttgtt caagggaacc ttgagagaga atgtatggaa 60
gaaaagtgta gttttgaaga agcacgagaa gtttttgaaa acactgaaag aacaactgaa 120
ttttggaagc agtatgttga tggagatcag tgtgagtcca atccatgttt aaatggcggc 180
agttgcaagg atgacattaa ttcctatgaa tgttggtgtc cctttggatt tgaaggaaag 240
aactgtgaat tagatgtaac atgtaacatt aagaatggca gatgcgagca gttttgtaaa 300
aatagtgctg ataacaaggt ggtttgctcc tgtactgagg gatatcgact tgcagaaaac 360
cagaagtcct gtgaaccagc agtgccattt ccatgtggaa gagtttctgt ttcacaaact 420
tctaagctca cccgtgctga gactgttttt cctgatgtgg actatgtaaa ttctactgaa 480
gctgaaacca ttttggataa catcactcaa agcacccaat catttaatga cttcactcgg 540
gttgttggtg gagaagatgc caaaccaggt caattccctt ggcaggttgt tttgaatggt 600
aaagttgatg cattctgtgg aggctctatc gttaatgaaa aatggattgt aactgctgcc 660
cactgtgttg aaactggtgt taaaattaca gttgtcgcag gtgaacataa tattgaggag 720
acagaacata cagagcaaaa gcgaaatgtg attcgaatta ttcctcacca caactacaat 780
gcagctatta ataagtacaa ccatgacatt gcccttctgg aactggacga acccttagtg 840
ctaaacagct acgttacacc tatttgcatt gctgacaagg aatacacgaa catcttcctc 900
aaatttggat ctggctatgt aagtggctgg ggaagagtct tccacaaagg gtactcagct 960
ttagttcttc agtaccttag agttccactt gttgaccgag ccacatgtct tgaatctaca 1020
aagttcagga tctataacaa catgttctgt gctggcttcc atgaaggagg tagagattca 1080
tgtcaaggag atagtggggg accccatgtt actgaagtgg aagggaccag tttcttaact 1140
ggaattatta gctggggtga agagtgtgca atgaaaggca aatatggaat atataccaag 1200
gtatcccggt atgtcaactg gattaaggaa aaaacaaagc tcact                 1245

<210> 484
<211> 1245
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX R338L mature

<400> 484
tataattcag gtaaattgga agagtttgtt caagggaacc ttgagagaga atgtatggaa 60
gaaaagtgta gttttgaaga agcacgagaa gtttttgaaa acactgaaag aacaactgaa 120
ttttggaagc agtatgttga tggagatcag tgtgagtcca atccatgttt aaatggcggc 180
agttgcaagg atgacattaa ttcctatgaa tgttggtgtc cctttggatt tgaaggaaag 240
aactgtgaat tagatgtaac atgtaacatt aagaatggca gatgcgagca gttttgtaaa 300
aatagtgctg ataacaaggt ggtttgctcc tgtactgagg gatatcgact tgcagaaaac 360
cagaagtcct gtgaaccagc agtgccattt ccatgtggaa gagtttctgt ttcacaaact 420
tctaagctca cccgtgctga gactgttttt cctgatgtgg actatgtaaa ttctactgaa 480
gctgaaacca ttttggataa catcactcaa agcacccaat catttaatga cttcactcgg 540
gttgttggtg gagaagatgc caaaccaggt caattccctt ggcaggttgt tttgaatggt 600
aaagttgatg cattctgtgg aggctctatc gttaatgaaa aatggattgt aactgctgcc 660
cactgtgttg aaactggtgt taaaattaca gttgtcgcag gtgaacataa tattgaggag 720
acagaacata cagagcaaaa gcgaaatgtg attcgaatta ttcctcacca caactacaat 780
gcagctatta ataagtacaa ccatgacatt gcccttctgg aactggacga acccttagtg 840
ctaaacagct acgttacacc tatttgcatt gctgacaagg aatacacgaa catcttcctc 900
aaatttggat ctggctatgt aagtggctgg ggaagagtct tccacaaagg gagatcagct 960
ttagttcttc agtaccttag agttccactt gttgaccgag ccacatgtct tctgtctaca 1020
aagttcacca tctataacaa catgttctgt gctggcttcc atgaaggagg tagagattca 1080
tgtcaaggag atagtggggg accccatgtt actgaagtgg aagggaccag tttcttaact 1140
ggaattatta gctggggtga agagtgtgca atgaaaggca aatatggaat atataccaag 1200
gtatcccggt atgtcaactg gattaaggaa aaaacaaagc tcact                 1245

<210> 485
<211> 1245
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX T148A mature

<400> 485
tataattcag gtaaattgga agagtttgtt caagggaacc ttgagagaga atgtatggaa 60
gaaaagtgta gttttgaaga agcacgagaa gtttttgaaa acactgaaag aacaactgaa 120
ttttggaagc agtatgttga tggagatcag tgtgagtcca atccatgttt aaatggcggc 180
agttgcaagg atgacattaa ttcctatgaa tgttggtgtc cctttggatt tgaaggaaag 240
aactgtgaat tagatgtaac atgtaacatt aagaatggca gatgcgagca gttttgtaaa 300
aatagtgctg ataacaaggt ggtttgctcc tgtactgagg gatatcgact tgcagaaaac 360
cagaagtcct gtgaaccagc agtgccattt ccatgtggaa gagtttctgt ttcacaaact 420
tctaagctca cccgtgctga ggctgttttt cctgatgtgg actatgtaaa ttctactgaa 480
gctgaaacca ttttggataa catcactcaa agcacccaat catttaatga cttcactcgg 540
gttgttggtg gagaagatgc caaaccaggt caattccctt ggcaggttgt tttgaatggt 600
aaagttgatg cattctgtgg aggctctatc gttaatgaaa aatggattgt aactgctgcc 660
cactgtgttg aaactggtgt taaaattaca gttgtcgcag gtgaacataa tattgaggag 720
acagaacata cagagcaaaa gcgaaatgtg attcgaatta ttcctcacca caactacaat 780
gcagctatta ataagtacaa ccatgacatt gcccttctgg aactggacga acccttagtg 840
ctaaacagct acgttacacc tatttgcatt gctgacaagg aatacacgaa catcttcctc 900
aaatttggat ctggctatgt aagtggctgg ggaagagtct tccacaaagg gagatcagct 960
ttagttcttc agtaccttag agttccactt gttgaccgag ccacatgtct tcgatctaca 1020
aagttcacca tctataacaa catgttctgt gctggcttcc atgaaggagg tagagattca 1080
tgtcaaggag atagtggggg accccatgtt actgaagtgg aagggaccag tttcttaact 1140
ggaattatta gctggggtga agagtgtgca atgaaaggca aatatggaat atataccaag 1200
gtatcccggt atgtcaactg gattaaggaa aaaacaaagc tcact                 1245

<210> 486
<211> 1245
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX T148A/R318Y/R338E/T343R mature

<400> 486
tataattcag gtaaattgga agagtttgtt caagggaacc ttgagagaga atgtatggaa 60
gaaaagtgta gttttgaaga agcacgagaa gtttttgaaa acactgaaag aacaactgaa 120
ttttggaagc agtatgttga tggagatcag tgtgagtcca atccatgttt aaatggcggc 180
agttgcaagg atgacattaa ttcctatgaa tgttggtgtc cctttggatt tgaaggaaag 240
aactgtgaat tagatgtaac atgtaacatt aagaatggca gatgcgagca gttttgtaaa 300
aatagtgctg ataacaaggt ggtttgctcc tgtactgagg gatatcgact tgcagaaaac 360
cagaagtcct gtgaaccagc agtgccattt ccatgtggaa gagtttctgt ttcacaaact 420
tctaagctca cccgtgctga ggctgttttt cctgatgtgg actatgtaaa ttctactgaa 480
gctgaaacca ttttggataa catcactcaa agcacccaat catttaatga cttcactcgg 540
gttgttggtg gagaagatgc caaaccaggt caattccctt ggcaggttgt tttgaatggt 600
aaagttgatg cattctgtgg aggctctatc gttaatgaaa aatggattgt aactgctgcc 660
cactgtgttg aaactggtgt taaaattaca gttgtcgcag gtgaacataa tattgaggag 720
acagaacata cagagcaaaa gcgaaatgtg attcgaatta ttcctcacca caactacaat 780
gcagctatta ataagtacaa ccatgacatt gcccttctgg aactggacga acccttagtg 840
ctaaacagct acgttacacc tatttgcatt gctgacaagg aatacacgaa catcttcctc 900
aaatttggat ctggctatgt aagtggctgg ggaagagtct tccacaaagg gtactcagct 960
ttagttcttc agtaccttag agttccactt gttgaccgag ccacatgtct tgaatctaca 1020
aagttcagga tctataacaa catgttctgt gctggcttcc atgaaggagg tagagattca 1080
tgtcaaggag atagtggggg accccatgtt actgaagtgg aagggaccag tttcttaact 1140
ggaattatta gctggggtga agagtgtgca atgaaaggca aatatggaat atataccaag 1200
gtatcccggt atgtcaactg gattaaggaa aaaacaaagc tcact                 1245

<210> 487
<211> 1245
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX T148A/R338L mature

<400> 487
tataattcag gtaaattgga agagtttgtt caagggaacc ttgagagaga atgtatggaa 60
gaaaagtgta gttttgaaga agcacgagaa gtttttgaaa acactgaaag aacaactgaa 120
ttttggaagc agtatgttga tggagatcag tgtgagtcca atccatgttt aaatggcggc 180
agttgcaagg atgacattaa ttcctatgaa tgttggtgtc cctttggatt tgaaggaaag 240
aactgtgaat tagatgtaac atgtaacatt aagaatggca gatgcgagca gttttgtaaa 300
aatagtgctg ataacaaggt ggtttgctcc tgtactgagg gatatcgact tgcagaaaac 360
cagaagtcct gtgaaccagc agtgccattt ccatgtggaa gagtttctgt ttcacaaact 420
tctaagctca cccgtgctga ggctgttttt cctgatgtgg actatgtaaa ttctactgaa 480
gctgaaacca ttttggataa catcactcaa agcacccaat catttaatga cttcactcgg 540
gttgttggtg gagaagatgc caaaccaggt caattccctt ggcaggttgt tttgaatggt 600
aaagttgatg cattctgtgg aggctctatc gttaatgaaa aatggattgt aactgctgcc 660
cactgtgttg aaactggtgt taaaattaca gttgtcgcag gtgaacataa tattgaggag 720
acagaacata cagagcaaaa gcgaaatgtg attcgaatta ttcctcacca caactacaat 780
gcagctatta ataagtacaa ccatgacatt gcccttctgg aactggacga acccttagtg 840
ctaaacagct acgttacacc tatttgcatt gctgacaagg aatacacgaa catcttcctc 900
aaatttggat ctggctatgt aagtggctgg ggaagagtct tccacaaagg gagatcagct 960
ttagttcttc agtaccttag agttccactt gttgaccgag ccacatgtct tctgtctaca 1020
aagttcacca tctataacaa catgttctgt gctggcttcc atgaaggagg tagagattca 1080
tgtcaaggag atagtggggg accccatgtt actgaagtgg aagggaccag tttcttaact 1140
ggaattatta gctggggtga agagtgtgca atgaaaggca aatatggaat atataccaag 1200
gtatcccggt atgtcaactg gattaaggaa aaaacaaagc tcact                 1245

<210> 488
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> human FIX R338L mature

<400> 488
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Leu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 489
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> human FIX T148A mature

<400> 489
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Ala Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 490
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> human FIX T148A/R318Y/R338E/T343R mature

<400> 490
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Ala Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Tyr Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Glu Ser Thr Lys Phe Arg Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 491
<211> 415
<212> PRT
<213> Artificial Sequence

<220> 
<223> human FIX T148A/R338L mature

<400> 491
Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg
 1               5                  10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr
    130                 135                 140                 
Arg Ala Glu Ala Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys
                325                 330                 335     
Leu Leu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr
                405                 410                 415 


<210> 492
<211> 737
<212> PRT
<213> Artificial Sequence

<220> 
<223> 10A4 capsid

<400> 492
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser
 1               5                  10                  15      
Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro
            20                  25                  30          
Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro
    50                  55                  60                  
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp
65                  70                  75                  80  
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro
        115                 120                 125             
Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg
    130                 135                 140                 
Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly
145                 150                 155                 160 
Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr
                165                 170                 175     
Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro
            180                 185                 190         
Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu
                245                 250                 255     
Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His
            260                 265                 270         
Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe
        275                 280                 285             
His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn
    290                 295                 300                 
Trp Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln
305                 310                 315                 320 
Val Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn
                325                 330                 335     
Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro
            340                 345                 350         
Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala
        355                 360                 365             
Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly
    370                 375                 380                 
Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro
385                 390                 395                 400 
Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe
                405                 410                 415     
Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp
            420                 425                 430         
Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg
        435                 440                 445             
Thr Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe
    450                 455                 460                 
Ser Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu
465                 470                 475                 480 
Pro Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp
                485                 490                 495     
Asn Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu
            500                 505                 510         
Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His
        515                 520                 525             
Lys Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe
    530                 535                 540                 
Gly Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met
545                 550                 555                 560 
Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu
                565                 570                 575     
Gln Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro
            580                 585                 590         
Thr Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp
        595                 600                 605             
Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro
    610                 615                 620                 
His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly
625                 630                 635                 640 
Leu Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro
                645                 650                 655     
Ala Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile
            660                 665                 670         
Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu
        675                 680                 685             
Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser
    690                 695                 700                 
Asn Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly
705                 710                 715                 720 
Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro
                725                 730                 735     
Leu
    


<210> 493
<211> 737
<212> PRT
<213> Artificial Sequence

<220> 
<223> 10A5 capsid

<400> 493
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser
 1               5                  10                  15      
Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro
            20                  25                  30          
Lys Ala Asn Gln Gln Lys Gln Asp Asp Ala Arg Gly Leu Val Leu Pro
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro
    50                  55                  60                  
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp
65                  70                  75                  80  
Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro
        115                 120                 125             
Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg
    130                 135                 140                 
Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly
145                 150                 155                 160 
Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr
                165                 170                 175     
Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro
            180                 185                 190         
Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu
                245                 250                 255     
Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His
            260                 265                 270         
Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe
        275                 280                 285             
His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn
    290                 295                 300                 
Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln
305                 310                 315                 320 
Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn
                325                 330                 335     
Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro
            340                 345                 350         
Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala
        355                 360                 365             
Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly
    370                 375                 380                 
Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro
385                 390                 395                 400 
Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe
                405                 410                 415     
Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp
            420                 425                 430         
Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg
        435                 440                 445             
Thr Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe
    450                 455                 460                 
Ser Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu
465                 470                 475                 480 
Pro Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp
                485                 490                 495     
Asn Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu
            500                 505                 510         
Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His
        515                 520                 525             
Lys Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe
    530                 535                 540                 
Gly Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met
545                 550                 555                 560 
Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu
                565                 570                 575     
Gln Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro
            580                 585                 590         
Thr Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp
        595                 600                 605             
Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro
    610                 615                 620                 
His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly
625                 630                 635                 640 
Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro
                645                 650                 655     
Ala Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile
            660                 665                 670         
Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu
        675                 680                 685             
Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser
    690                 695                 700                 
Asn Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly
705                 710                 715                 720 
Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro
                725                 730                 735     
Leu
    


<210> 494
<211> 737
<212> PRT
<213> Artificial Sequence

<220> 
<223> 10B1 capsid

<400> 494
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser
 1               5                  10                  15      
Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro
            20                  25                  30          
Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro
    50                  55                  60                  
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp
65                  70                  75                  80  
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro
        115                 120                 125             
Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg
    130                 135                 140                 
Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Ile Gly
145                 150                 155                 160 
Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr
                165                 170                 175     
Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro
            180                 185                 190         
Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Gly Gly
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu
                245                 250                 255     
Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His
            260                 265                 270         
Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe
        275                 280                 285             
His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn
    290                 295                 300                 
Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln
305                 310                 315                 320 
Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn
                325                 330                 335     
Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro
            340                 345                 350         
Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala
        355                 360                 365             
Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly
    370                 375                 380                 
Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro
385                 390                 395                 400 
Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr Phe
                405                 410                 415     
Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp
            420                 425                 430         
Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg
        435                 440                 445             
Thr Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe
    450                 455                 460                 
Ser Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu
465                 470                 475                 480 
Pro Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp
                485                 490                 495     
Asn Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu
            500                 505                 510         
Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His
        515                 520                 525             
Lys Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe
    530                 535                 540                 
Gly Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met
545                 550                 555                 560 
Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu
                565                 570                 575     
Gln Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro
            580                 585                 590         
Thr Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp
        595                 600                 605             
Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro
    610                 615                 620                 
His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly
625                 630                 635                 640 
Leu Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro
                645                 650                 655     
Ala Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile
            660                 665                 670         
Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu
        675                 680                 685             
Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser
    690                 695                 700                 
Asn Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly
705                 710                 715                 720 
Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro
                725                 730                 735     
Leu
    


<210> 495
<211> 737
<212> PRT
<213> Artificial Sequence

<220> 
<223> 10B3 capsid

<400> 495
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser
 1               5                  10                  15      
Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro
            20                  25                  30          
Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro
    50                  55                  60                  
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp
65                  70                  75                  80  
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro
        115                 120                 125             
Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg
    130                 135                 140                 
Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly
145                 150                 155                 160 
Lys Ala Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr
                165                 170                 175     
Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro
            180                 185                 190         
Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly Gly
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu
                245                 250                 255     
Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His
            260                 265                 270         
Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe
        275                 280                 285             
His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn
    290                 295                 300                 
Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln
305                 310                 315                 320 
Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn
                325                 330                 335     
Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro
            340                 345                 350         
Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala
        355                 360                 365             
Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly
    370                 375                 380                 
Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro
385                 390                 395                 400 
Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe
                405                 410                 415     
Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp
            420                 425                 430         
Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg
        435                 440                 445             
Thr Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe
    450                 455                 460                 
Ser Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu
465                 470                 475                 480 
Pro Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp
                485                 490                 495     
Asn Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu
            500                 505                 510         
Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His
        515                 520                 525             
Lys Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe
    530                 535                 540                 
Gly Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met
545                 550                 555                 560 
Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu
                565                 570                 575     
Gln Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro
            580                 585                 590         
Thr Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp
        595                 600                 605             
Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro
    610                 615                 620                 
His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly
625                 630                 635                 640 
Leu Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro
                645                 650                 655     
Ala Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile
            660                 665                 670         
Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu
        675                 680                 685             
Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser
    690                 695                 700                 
Asn Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly
705                 710                 715                 720 
Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro
                725                 730                 735     
Leu
    


<210> 496
<211> 737
<212> PRT
<213> Artificial Sequence

<220> 
<223> 10B5 capsid

<400> 496
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser
 1               5                  10                  15      
Glu Gly Ile Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro
            20                  25                  30          
Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro
    50                  55                  60                  
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp
65                  70                  75                  80  
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro
        115                 120                 125             
Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg
    130                 135                 140                 
Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly
145                 150                 155                 160 
Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr
                165                 170                 175     
Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro
            180                 185                 190         
Ala Gly Pro Ser Gly Leu Gly Thr Gly Thr Met Ala Ser Gly Ser Gly
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu
                245                 250                 255     
Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His
            260                 265                 270         
Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe
        275                 280                 285             
His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn
    290                 295                 300                 
Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln
305                 310                 315                 320 
Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn
                325                 330                 335     
Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro
            340                 345                 350         
Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala
        355                 360                 365             
Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly
    370                 375                 380                 
Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro
385                 390                 395                 400 
Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe
                405                 410                 415     
Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp
            420                 425                 430         
Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg
        435                 440                 445             
Thr Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe
    450                 455                 460                 
Ser Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu
465                 470                 475                 480 
Pro Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp
                485                 490                 495     
Asn Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu
            500                 505                 510         
Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His
        515                 520                 525             
Lys Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe
    530                 535                 540                 
Gly Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met
545                 550                 555                 560 
Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu
                565                 570                 575     
Gln Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro
            580                 585                 590         
Thr Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp
        595                 600                 605             
Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro
    610                 615                 620                 
His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly
625                 630                 635                 640 
Leu Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro
                645                 650                 655     
Ala Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile
            660                 665                 670         
Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu
        675                 680                 685             
Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser
    690                 695                 700                 
Asn Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly
705                 710                 715                 720 
Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro
                725                 730                 735     
Leu
    


<210> 497
<211> 737
<212> PRT
<213> Artificial Sequence

<220> 
<223> 10B6 capsid

<400> 497
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser
 1               5                  10                  15      
Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro
            20                  25                  30          
Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro
    50                  55                  60                  
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp
65                  70                  75                  80  
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro
        115                 120                 125             
Phe Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg
    130                 135                 140                 
Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly
145                 150                 155                 160 
Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr
                165                 170                 175     
Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro
            180                 185                 190         
Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu
                245                 250                 255     
Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His
            260                 265                 270         
Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe
        275                 280                 285             
His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn
    290                 295                 300                 
Trp Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln
305                 310                 315                 320 
Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn
                325                 330                 335     
Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro
            340                 345                 350         
Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala
        355                 360                 365             
Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly
    370                 375                 380                 
Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro
385                 390                 395                 400 
Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr Phe
                405                 410                 415     
Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp
            420                 425                 430         
Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg
        435                 440                 445             
Thr Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe
    450                 455                 460                 
Ser Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu
465                 470                 475                 480 
Pro Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp
                485                 490                 495     
Asn Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu
            500                 505                 510         
Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His
        515                 520                 525             
Lys Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe
    530                 535                 540                 
Gly Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met
545                 550                 555                 560 
Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu
                565                 570                 575     
Gln Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro
            580                 585                 590         
Thr Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp
        595                 600                 605             
Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro
    610                 615                 620                 
His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly
625                 630                 635                 640 
Met Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro
                645                 650                 655     
Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile
            660                 665                 670         
Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu
        675                 680                 685             
Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser
    690                 695                 700                 
Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly
705                 710                 715                 720 
Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn
                725                 730                 735     
Leu
    


<210> 498
<211> 736
<212> PRT
<213> Artificial Sequence

<220> 
<223> 10B7 capsid

<400> 498
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser
 1               5                  10                  15      
Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro
            20                  25                  30          
Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro
    50                  55                  60                  
Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp
65                  70                  75                  80  
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro
        115                 120                 125             
Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg
    130                 135                 140                 
Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly
145                 150                 155                 160 
Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr
                165                 170                 175     
Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro
            180                 185                 190         
Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu
                245                 250                 255     
Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His
            260                 265                 270         
Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe
        275                 280                 285             
His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn
    290                 295                 300                 
Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln
305                 310                 315                 320 
Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn
                325                 330                 335     
Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro
            340                 345                 350         
Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala
        355                 360                 365             
Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly
    370                 375                 380                 
Ser Gln Ala Met Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro
385                 390                 395                 400 
Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe
                405                 410                 415     
Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp
            420                 425                 430         
Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg
        435                 440                 445             
Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu Phe Ser
    450                 455                 460                 
Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Arg Asn Trp Leu Pro
465                 470                 475                 480 
Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn
                485                 490                 495     
Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn
            500                 505                 510         
Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys
        515                 520                 525             
Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly
    530                 535                 540                 
Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile
545                 550                 555                 560 
Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln
                565                 570                 575     
Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr
            580                 585                 590         
Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln
        595                 600                 605             
Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His
    610                 615                 620                 
Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu
625                 630                 635                 640 
Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala
                645                 650                 655     
Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile Thr
            660                 665                 670         
Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln
        675                 680                 685             
Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn
    690                 695                 700                 
Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val
705                 710                 715                 720 
Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu
                725                 730                 735     


<210> 499
<211> 737
<212> PRT
<213> Artificial Sequence

<220> 
<223> 18B2 capsid

<400> 499
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser
 1               5                  10                  15      
Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro
            20                  25                  30          
Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro
    50                  55                  60                  
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp
65                  70                  75                  80  
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro
        115                 120                 125             
Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg
    130                 135                 140                 
Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly
145                 150                 155                 160 
Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr
                165                 170                 175     
Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro
            180                 185                 190         
Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ser Gly Gly Gly
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu
                245                 250                 255     
Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His
            260                 265                 270         
Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe
        275                 280                 285             
His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn
    290                 295                 300                 
Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln
305                 310                 315                 320 
Val Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn
                325                 330                 335     
Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro
            340                 345                 350         
Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala
        355                 360                 365             
Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly
    370                 375                 380                 
Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro
385                 390                 395                 400 
Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe
                405                 410                 415     
Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp
            420                 425                 430         
Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg
        435                 440                 445             
Thr Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe
    450                 455                 460                 
Ser Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu
465                 470                 475                 480 
Pro Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp
                485                 490                 495     
Asn Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu
            500                 505                 510         
Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His
        515                 520                 525             
Lys Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe
    530                 535                 540                 
Gly Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met
545                 550                 555                 560 
Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu
                565                 570                 575     
Gln Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro
            580                 585                 590         
Thr Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp
        595                 600                 605             
Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro
    610                 615                 620                 
His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly
625                 630                 635                 640 
Leu Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro
                645                 650                 655     
Ala Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile
            660                 665                 670         
Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu
        675                 680                 685             
Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser
    690                 695                 700                 
Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly
705                 710                 715                 720 
Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn
                725                 730                 735     
Leu
    


<210> 500
<211> 737
<212> PRT
<213> Artificial Sequence

<220> 
<223> 18B3 capsid

<400> 500
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser
 1               5                  10                  15      
Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro
            20                  25                  30          
Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro
    50                  55                  60                  
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp
65                  70                  75                  80  
Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro
        115                 120                 125             
Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg
    130                 135                 140                 
Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly
145                 150                 155                 160 
Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr
                165                 170                 175     
Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro
            180                 185                 190         
Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ala Gly Gly Gly
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu
                245                 250                 255     
Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His
            260                 265                 270         
Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe
        275                 280                 285             
His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn
    290                 295                 300                 
Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln
305                 310                 315                 320 
Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn
                325                 330                 335     
Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro
            340                 345                 350         
Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala
        355                 360                 365             
Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly
    370                 375                 380                 
Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro
385                 390                 395                 400 
Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe
                405                 410                 415     
Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp
            420                 425                 430         
Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg
        435                 440                 445             
Thr Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe
    450                 455                 460                 
Ser Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu
465                 470                 475                 480 
Pro Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp
                485                 490                 495     
Asn Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu
            500                 505                 510         
Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His
        515                 520                 525             
Lys Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe
    530                 535                 540                 
Gly Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met
545                 550                 555                 560 
Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu
                565                 570                 575     
Gln Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro
            580                 585                 590         
Thr Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp
        595                 600                 605             
Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro
    610                 615                 620                 
His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly
625                 630                 635                 640 
Leu Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro
                645                 650                 655     
Ala Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile
            660                 665                 670         
Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu
        675                 680                 685             
Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser
    690                 695                 700                 
Asn Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly
705                 710                 715                 720 
Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro
                725                 730                 735     
Leu
    


<210> 501
<211> 145
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV2 ITR

<400> 501
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg 60
ccgcccgggg aaaccccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc 120
gagcgcgcag agagggagtg gccaa                                       145

<210> 502
<211> 143
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV1 ITR

<220> 
<223> GenBank: AF063497.1

<400> 502
ttacccctag tgatggagtt gcccactccc tctctgcgcg ctcgctcgct cggtggggcc 60
tgcggaccaa aggtccgcag acggcagagc tctgctctgc cggccccacc gagcgagcga 120
gcgcgcagag agggagtggg caa                                         143

<210> 503
<211> 134
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV3 ITR

<220> 
<223> Genbank U48704.1

<400> 503
gtgatggagt tggccactcc ctctatgcgc actcgctcgc tcggtggggc ctggcgacca 60
aaggtcgcca gacggacgtg ctttgcacgt ccggccccac cgagcgagcg agtgcgcata 120
gagggagtgg ccaa                                                   134

<210> 504
<211> 146
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV4 ITR

<400> 504
gggcaaacct agatgatgga gttggccact ccctctatgc gcgctcgctc actcactcgg 60
ccctgccggc cagaggccgg cagtctggag acctttggtc tccagggccg agtgagtgag 120
cgagcgcgca tagagggagt ggccaa                                      146

<210> 505
<211> 144
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV4 ITR

<220> 
<223> GenBank: U89790.1

<400> 505
ggcaaaccag atgatggagt tggccacatt agctatgcgc gctcgctcac tcactcggcc 60
ctggagacca aaggtctcca gactgccggc ctctggccgg cagggccgag tgagtgagcg 120
agcgcgcata gagggagtgg ccaa                                        144

<210> 506
<211> 165
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV5 ITR

<400> 506
tacaaaacct ccttgcttga gagtgtggca ctctccccct gtcgcgttcg cgcgctcgct 60
ggctcgtttg gggggcgacg gccagagggc cgtcgtctgg cagctctttg agctgccacc 120
cccccaaacg agccagcgag cgcgcgaacg cgacaggggg gagag                 165

<210> 507
<211> 167
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV5 ITR

<220> 
<223> GenBank: AF085716.1

<400> 507
tacaaaacct ccttgcttga gagtgtggca ctctcccccc tgtcgcgttc gctcgctcgc 60
tggctcgttt gggggggtgg cagctcaaag agctgccaga cgacggccct ctggccgtcg 120
cccccccaaa cgagccagcg agcgagcgaa cgcgacaggg gggagag               167

<210> 508
<211> 143
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV6 ITR

<400> 508
atacccctag tgatggagtt gcccactccc tctatgcgcg ctcgctcgct cggtggggcc 60
ggcagaggag acctctgccg tctgcggacc tttggtccgc aggccccacc gagcgagcga 120
gcgcgcatag agggagtggg caa                                         143

<210> 509
<211> 143
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV6 ITR

<220> 
<223> GenBank: AF028704.1

<400> 509
atacccctag tgatggagtt gcccactccc tctatgcgcg ctcgctcgct cggtggggcc 60
ggcagagcag agctctgccg tctgcggacc tttggtccgc aggccccacc gagcgagcga 120
gcgcgcatag agggagtggg caa                                         143

<210> 510
<211> 141
<212> DNA
<213> Artificial Sequence

<220> 
<223> R ITR

<400> 510
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60
gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120
actccatcac taggggttcc t                                           141

<210> 511
<211> 141
<212> DNA
<213> Artificial Sequence

<220> 
<223> L ITR

<400> 511
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg 60
ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc 120
gagcgcgcag ctgcctgcag g                                           141

<210> 512
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> BGH sequencing primer fwd

<400> 512
gccttctagt tgccagccat                                             20

<210> 513
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> BGH sequencing primer rev

<400> 513
ggcaccttcc agggtcaag                                              19

<210> 514
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> FIX forward PCR primer

<400> 514
atctacaaca acatgttctg cg                                          22

<210> 515
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> FIX reverse PCR primer

<400> 515
ctgatgatgc cggtcagaaa                                             20

<210> 516
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> GAPDH forward PCR primer

<400> 516
tgtgtccgtc gtggatctga                                             20

<210> 517
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> GAPDH reverse PCR primer

<400> 517
gcctgcttca ccaccttctt ga                                          22

<210> 518
<211> 1245
<212> DNA
<213> Artificial Sequence

<220> 
<223> hWT-FIX mature codon optimized for human 0.5
      optimization

<400> 518
tataattcag gcaaactgga agagtttgtg caggggaacc tggagagaga atgtatggaa 60
gaaaagtgta gttttgaaga agcacgagaa gtgtttgaaa acactgaaag aacaactgaa 120
ttttggaagc agtatgtgga tggagatcag tgtgagtcca atccatgtct gaatggcggc 180
agttgcaagg atgacattaa ttcctatgaa tgttggtgtc cctttggatt tgaaggaaag 240
aactgtgaac tggatgtgac atgtaacatt aagaatggca gatgcgagca gttttgtaaa 300
aatagtgctg ataacaaggt ggtgtgctcc tgtactgagg gatatcgact ggcagaaaac 360
cagaagtcct gtgaaccagc agtgccattt ccatgtggaa gagtgtctgt gtcacagact 420
tctaagctga cccgggctga gactgtgttt cctgatgtgg actatgtgaa ttctactgaa 480
gctgaaacca ttctggataa catcactcag agcacccagt catttaatga cttcactcgg 540
gtggtgggcg gagaagatgc caaaccaggc cagttccctt ggcaggtggt gctgaatggc 600
aaagtggatg cattctgtgg aggctctatc gtgaatgaaa aatggattgt gactgctgcc 660
cactgtgtgg aaactggcgt gaaaattaca gtggtcgcag gcgaacataa tattgaggag 720
acagaacata cagagcagaa gcgaaatgtg attcgaatta ttcctcacca caactacaat 780
gcagctatta ataagtacaa ccatgacatt gccctgctgg aactggacga acccctggtg 840
ctgaacagct acgtgacacc tatttgcatt gctgacaagg aatacaccaa catcttcctg 900
aaatttggat ctggctatgt gagtggctgg ggaagagtct tccacaaagg gagatcagct 960
ctggtgctgc agtacctgag agtgccactg gtggaccgag ccacatgtct gcgatctaca 1020
aagttcacca tctataacaa catgttctgt gctggcttcc atgaaggagg cagagattca 1080
tgtcagggag atagtggggg accccatgtg actgaagtgg aagggaccag tttcctgact 1140
ggaattatta gctggggcga agagtgtgca atgaaaggca aatatggaat ctataccaag 1200
gtgtcccggt atgtcaactg gattaaggaa aaaacaaagc tgact                 1245

<210> 519
<211> 1245
<212> DNA
<213> Artificial Sequence

<220> 
<223> hWT-FIX mature codon optimized for human 0.8
      optimization

<400> 519
tacaatagcg gcaagctgga ggagtttgtg cagggcaacc tggagagaga gtgtatggag 60
gagaagtgta gctttgagga ggcccgggag gtgtttgaga acaccgagag aaccaccgag 120
ttttggaagc agtacgtgga tggcgatcag tgtgagtcca atccatgtct gaatggcggc 180
agctgcaagg atgacatcaa ttcctacgag tgttggtgtc cctttggctt tgagggcaag 240
aactgtgagc tggatgtgac ctgtaacatc aagaatggca gatgcgagca gttttgtaag 300
aatagcgccg ataacaaggt ggtgtgctcc tgtaccgagg gctaccggct ggccgagaac 360
cagaagtcct gtgagccagc cgtgccattt ccatgtggca gagtgagcgt gagccagacc 420
agcaagctga cccgggccga gaccgtgttt cctgatgtgg actacgtgaa tagcaccgag 480
gccgagacca tcctggataa catcacccag agcacccaga gctttaatga cttcacccgg 540
gtggtgggcg gcgaggatgc caagccaggc cagttccctt ggcaggtggt gctgaatggc 600
aaggtggatg ccttctgtgg cggcagcatc gtgaatgaga agtggatcgt gaccgccgcc 660
cactgtgtgg agaccggcgt gaagatcacc gtggtggccg gcgagcacaa tatcgaggag 720
accgagcaca ccgagcagaa gcggaatgtg atccggatca tccctcacca caactacaat 780
gccgccatca ataagtacaa ccacgacatc gccctgctgg agctggacga gcccctggtg 840
ctgaacagct acgtgacccc tatctgcatc gccgacaagg agtacaccaa catcttcctg 900
aagtttggca gcggctacgt gagcggctgg ggcagagtgt tccacaaggg cagaagcgcc 960
ctggtgctgc agtacctgag agtgccactg gtggaccggg ccacctgtct gcggagcacc 1020
aagttcacca tctacaacaa catgttctgt gccggcttcc acgagggcgg cagagatagc 1080
tgtcagggcg atagcggcgg cccccacgtg accgaggtgg agggcaccag cttcctgacc 1140
ggcatcatca gctggggcga ggagtgtgcc atgaagggca agtacggcat ctacaccaag 1200
gtgtcccggt acgtgaactg gatcaaggag aagaccaagc tgacc                 1245

<210> 520
<211> 1245
<212> DNA
<213> Artificial Sequence

<220> 
<223> hWT-FIX mature codon optimized for human 1.0
      optimization

<400> 520
tacaacagcg gcaagctgga ggagttcgtg cagggcaacc tggagcggga gtgcatggag 60
gagaagtgca gcttcgagga ggcccgggag gtgttcgaga acaccgagcg gaccaccgag 120
ttctggaagc agtacgtgga cggcgaccag tgcgagagca acccctgcct gaacggcggc 180
agctgcaagg acgacatcaa cagctacgag tgctggtgcc ccttcggctt cgagggcaag 240
aactgcgagc tggacgtgac ctgcaacatc aagaacggcc ggtgcgagca gttctgcaag 300
aacagcgccg acaacaaggt ggtgtgcagc tgcaccgagg gctaccggct ggccgagaac 360
cagaagagct gcgagcccgc cgtgcccttc ccctgcggcc gggtgagcgt gagccagacc 420
agcaagctga cccgggccga gaccgtgttc cccgacgtgg actacgtgaa cagcaccgag 480
gccgagacca tcctggacaa catcacccag agcacccaga gcttcaacga cttcacccgg 540
gtggtgggcg gcgaggacgc caagcccggc cagttcccct ggcaggtggt gctgaacggc 600
aaggtggacg ccttctgcgg cggcagcatc gtgaacgaga agtggatcgt gaccgccgcc 660
cactgcgtgg agaccggcgt gaagatcacc gtggtggccg gcgagcacaa catcgaggag 720
accgagcaca ccgagcagaa gcggaacgtg atccggatca tcccccacca caactacaac 780
gccgccatca acaagtacaa ccacgacatc gccctgctgg agctggacga gcccctggtg 840
ctgaacagct acgtgacccc catctgcatc gccgacaagg agtacaccaa catcttcctg 900
aagttcggca gcggctacgt gagcggctgg ggccgggtgt tccacaaggg ccggagcgcc 960
ctggtgctgc agtacctgcg ggtgcccctg gtggaccggg ccacctgcct gcggagcacc 1020
aagttcacca tctacaacaa catgttctgc gccggcttcc acgagggcgg ccgggacagc 1080
tgccagggcg acagcggcgg cccccacgtg accgaggtgg agggcaccag cttcctgacc 1140
ggcatcatca gctggggcga ggagtgcgcc atgaagggca agtacggcat ctacaccaag 1200
gtgagccggt acgtgaactg gatcaaggag aagaccaagc tgacc                 1245

<210> 521
<211> 1245
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX R318Y/R338E/T343R -FIX mature codon
      optimized for human 0.5 optimization

<400> 521
tataattcag gcaaactgga agagtttgtg caggggaacc tggagagaga atgtatggaa 60
gaaaagtgta gttttgaaga agcacgagaa gtgtttgaaa acactgaaag aacaactgaa 120
ttttggaagc agtatgtgga tggagatcag tgtgagtcca atccatgtct gaatggcggc 180
agttgcaagg atgacattaa ttcctatgaa tgttggtgtc cctttggatt tgaaggaaag 240
aactgtgaac tggatgtgac atgtaacatt aagaatggca gatgcgagca gttttgtaaa 300
aatagtgctg ataacaaggt ggtgtgctcc tgtactgagg gatatcgact ggcagaaaac 360
cagaagtcct gtgaaccagc agtgccattt ccatgtggaa gagtgtctgt gtcacagact 420
tctaagctga cccgggctga gactgtgttt cctgatgtgg actatgtgaa ttctactgaa 480
gctgaaacca ttctggataa catcactcag agcacccagt catttaatga cttcactcgg 540
gtggtgggcg gagaagatgc caaaccaggc cagttccctt ggcaggtggt gctgaatggc 600
aaagtggatg cattctgtgg aggctctatc gtgaatgaaa aatggattgt gactgctgcc 660
cactgtgtgg aaactggcgt gaaaattaca gtggtcgcag gcgaacataa tattgaggag 720
acagaacata cagagcagaa gcgaaatgtg attcgaatta ttcctcacca caactacaat 780
gcagctatta ataagtacaa ccatgacatt gccctgctgg aactggacga acccctggtg 840
ctgaacagct acgtgacacc tatttgcatt gctgacaagg aatacaccaa catcttcctg 900
aaatttggat ctggctatgt gagtggctgg ggaagagtct tccacaaagg gtactcagct 960
ctggtgctgc agtacctgag agtgccactg gtggaccgag ccacatgtct ggagtctaca 1020
aagttccgga tctataacaa catgttctgt gctggcttcc atgaaggagg cagagattca 1080
tgtcagggag atagtggggg accccatgtg actgaagtgg aagggaccag tttcctgact 1140
ggaattatta gctggggcga agagtgtgca atgaaaggca aatatggaat ctataccaag 1200
gtgtcccggt atgtcaactg gattaaggaa aaaacaaagc tgact                 1245

<210> 522
<211> 1245
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX R318Y/R338E/T343R -FIX mature codon
      optimized for human 0.8 optimization

<400> 522
tacaatagcg gcaagctgga ggagtttgtg cagggcaacc tggagagaga gtgtatggag 60
gagaagtgta gctttgagga ggcccgggag gtgtttgaga acaccgagag aaccaccgag 120
ttttggaagc agtacgtgga tggcgatcag tgtgagtcca atccatgtct gaatggcggc 180
agctgcaagg atgacatcaa ttcctacgag tgttggtgtc cctttggctt tgagggcaag 240
aactgtgagc tggatgtgac ctgtaacatc aagaatggca gatgcgagca gttttgtaag 300
aatagcgccg ataacaaggt ggtgtgctcc tgtaccgagg gctaccggct ggccgagaac 360
cagaagtcct gtgagccagc cgtgccattt ccatgtggca gagtgagcgt gagccagacc 420
agcaagctga cccgggccga gaccgtgttt cctgatgtgg actacgtgaa tagcaccgag 480
gccgagacca tcctggataa catcacccag agcacccaga gctttaatga cttcacccgg 540
gtggtgggcg gcgaggatgc caagccaggc cagttccctt ggcaggtggt gctgaatggc 600
aaggtggatg ccttctgtgg cggcagcatc gtgaatgaga agtggatcgt gaccgccgcc 660
cactgtgtgg agaccggcgt gaagatcacc gtggtggccg gcgagcacaa tatcgaggag 720
accgagcaca ccgagcagaa gcggaatgtg atccggatca tccctcacca caactacaat 780
gccgccatca ataagtacaa ccacgacatc gccctgctgg agctggacga gcccctggtg 840
ctgaacagct acgtgacccc tatctgcatc gccgacaagg agtacaccaa catcttcctg 900
aagtttggca gcggctacgt gagcggctgg ggcagagtgt tccacaaggg ctacagcgcc 960
ctggtgctgc agtacctgag agtgccactg gtggaccggg ccacctgtct ggagagcacc 1020
aagttccgga tctacaacaa catgttctgt gccggcttcc acgagggcgg cagagatagc 1080
tgtcagggcg atagcggcgg cccccacgtg accgaggtgg agggcaccag cttcctgacc 1140
ggcatcatca gctggggcga ggagtgtgcc atgaagggca agtacggcat ctacaccaag 1200
gtgtcccggt acgtgaactg gatcaaggag aagaccaagc tgacc                 1245

<210> 523
<211> 1245
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX R318Y/R338E/T343R -FIX mature codon
      optimized for human 1.0 optimization

<400> 523
tacaacagcg gcaagctgga ggagttcgtg cagggcaacc tggagcggga gtgcatggag 60
gagaagtgca gcttcgagga ggcccgggag gtgttcgaga acaccgagcg gaccaccgag 120
ttctggaagc agtacgtgga cggcgaccag tgcgagagca acccctgcct gaacggcggc 180
agctgcaagg acgacatcaa cagctacgag tgctggtgcc ccttcggctt cgagggcaag 240
aactgcgagc tggacgtgac ctgcaacatc aagaacggcc ggtgcgagca gttctgcaag 300
aacagcgccg acaacaaggt ggtgtgcagc tgcaccgagg gctaccggct ggccgagaac 360
cagaagagct gcgagcccgc cgtgcccttc ccctgcggcc gggtgagcgt gagccagacc 420
agcaagctga cccgggccga gaccgtgttc cccgacgtgg actacgtgaa cagcaccgag 480
gccgagacca tcctggacaa catcacccag agcacccaga gcttcaacga cttcacccgg 540
gtggtgggcg gcgaggacgc caagcccggc cagttcccct ggcaggtggt gctgaacggc 600
aaggtggacg ccttctgcgg cggcagcatc gtgaacgaga agtggatcgt gaccgccgcc 660
cactgcgtgg agaccggcgt gaagatcacc gtggtggccg gcgagcacaa catcgaggag 720
accgagcaca ccgagcagaa gcggaacgtg atccggatca tcccccacca caactacaac 780
gccgccatca acaagtacaa ccacgacatc gccctgctgg agctggacga gcccctggtg 840
ctgaacagct acgtgacccc catctgcatc gccgacaagg agtacaccaa catcttcctg 900
aagttcggca gcggctacgt gagcggctgg ggccgggtgt tccacaaggg ctacagcgcc 960
ctggtgctgc agtacctgcg ggtgcccctg gtggaccggg ccacctgcct ggagagcacc 1020
aagttccgga tctacaacaa catgttctgc gccggcttcc acgagggcgg ccgggacagc 1080
tgccagggcg acagcggcgg cccccacgtg accgaggtgg agggcaccag cttcctgacc 1140
ggcatcatca gctggggcga ggagtgcgcc atgaagggca agtacggcat ctacaccaag 1200
gtgagccggt acgtgaactg gatcaaggag aagaccaagc tgacc                 1245

<210> 524
<211> 1245
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX R338L-FIX mature codon optimized for
      human 0.5 optimization

<400> 524
tataattcag gcaaactgga agagtttgtg caggggaacc tggagagaga atgtatggaa 60
gaaaagtgta gttttgaaga agcacgagaa gtgtttgaaa acactgaaag aacaactgaa 120
ttttggaagc agtatgtgga tggagatcag tgtgagtcca atccatgtct gaatggcggc 180
agttgcaagg atgacattaa ttcctatgaa tgttggtgtc cctttggatt tgaaggaaag 240
aactgtgaac tggatgtgac atgtaacatt aagaatggca gatgcgagca gttttgtaaa 300
aatagtgctg ataacaaggt ggtgtgctcc tgtactgagg gatatcgact ggcagaaaac 360
cagaagtcct gtgaaccagc agtgccattt ccatgtggaa gagtgtctgt gtcacagact 420
tctaagctga cccgggctga gactgtgttt cctgatgtgg actatgtgaa ttctactgaa 480
gctgaaacca ttctggataa catcactcag agcacccagt catttaatga cttcactcgg 540
gtggtgggcg gagaagatgc caaaccaggc cagttccctt ggcaggtggt gctgaatggc 600
aaagtggatg cattctgtgg aggctctatc gtgaatgaaa aatggattgt gactgctgcc 660
cactgtgtgg aaactggcgt gaaaattaca gtggtcgcag gcgaacataa tattgaggag 720
acagaacata cagagcagaa gcgaaatgtg attcgaatta ttcctcacca caactacaat 780
gcagctatta ataagtacaa ccatgacatt gccctgctgg aactggacga acccctggtg 840
ctgaacagct acgtgacacc tatttgcatt gctgacaagg aatacaccaa catcttcctg 900
aaatttggat ctggctatgt gagtggctgg ggaagagtct tccacaaagg gagatcagct 960
ctggtgctgc agtacctgag agtgccactg gtggaccgag ccacatgtct gctgtctaca 1020
aagttcacca tctataacaa catgttctgt gctggcttcc atgaaggagg cagagattca 1080
tgtcagggag atagtggggg accccatgtg actgaagtgg aagggaccag tttcctgact 1140
ggaattatta gctggggcga agagtgtgca atgaaaggca aatatggaat ctataccaag 1200
gtgtcccggt atgtcaactg gattaaggaa aaaacaaagc tgact                 1245

<210> 525
<211> 1245
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX R338L-FIX mature codon optimized for
      human 0.8 optimization

<400> 525
tacaatagcg gcaagctgga ggagtttgtg cagggcaacc tggagagaga gtgtatggag 60
gagaagtgta gctttgagga ggcccgggag gtgtttgaga acaccgagag aaccaccgag 120
ttttggaagc agtacgtgga tggcgatcag tgtgagtcca atccatgtct gaatggcggc 180
agctgcaagg atgacatcaa ttcctacgag tgttggtgtc cctttggctt tgagggcaag 240
aactgtgagc tggatgtgac ctgtaacatc aagaatggca gatgcgagca gttttgtaag 300
aatagcgccg ataacaaggt ggtgtgctcc tgtaccgagg gctaccggct ggccgagaac 360
cagaagtcct gtgagccagc cgtgccattt ccatgtggca gagtgagcgt gagccagacc 420
agcaagctga cccgggccga gaccgtgttt cctgatgtgg actacgtgaa tagcaccgag 480
gccgagacca tcctggataa catcacccag agcacccaga gctttaatga cttcacccgg 540
gtggtgggcg gcgaggatgc caagccaggc cagttccctt ggcaggtggt gctgaatggc 600
aaggtggatg ccttctgtgg cggcagcatc gtgaatgaga agtggatcgt gaccgccgcc 660
cactgtgtgg agaccggcgt gaagatcacc gtggtggccg gcgagcacaa tatcgaggag 720
accgagcaca ccgagcagaa gcggaatgtg atccggatca tccctcacca caactacaat 780
gccgccatca ataagtacaa ccacgacatc gccctgctgg agctggacga gcccctggtg 840
ctgaacagct acgtgacccc tatctgcatc gccgacaagg agtacaccaa catcttcctg 900
aagtttggca gcggctacgt gagcggctgg ggcagagtgt tccacaaggg cagaagcgcc 960
ctggtgctgc agtacctgag agtgccactg gtggaccggg ccacctgtct gctgagcacc 1020
aagttcacca tctacaacaa catgttctgt gccggcttcc acgagggcgg cagagatagc 1080
tgtcagggcg atagcggcgg cccccacgtg accgaggtgg agggcaccag cttcctgacc 1140
ggcatcatca gctggggcga ggagtgtgcc atgaagggca agtacggcat ctacaccaag 1200
gtgtcccggt acgtgaactg gatcaaggag aagaccaagc tgacc                 1245

<210> 526
<211> 1245
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX R338L mature codon optimized for human
      1.0 optimization

<400> 526
tacaacagcg gcaagctgga ggagttcgtg cagggcaacc tggagcggga gtgcatggag 60
gagaagtgca gcttcgagga ggcccgggag gtgttcgaga acaccgagcg gaccaccgag 120
ttctggaagc agtacgtgga cggcgaccag tgcgagagca acccctgcct gaacggcggc 180
agctgcaagg acgacatcaa cagctacgag tgctggtgcc ccttcggctt cgagggcaag 240
aactgcgagc tggacgtgac ctgcaacatc aagaacggcc ggtgcgagca gttctgcaag 300
aacagcgccg acaacaaggt ggtgtgcagc tgcaccgagg gctaccggct ggccgagaac 360
cagaagagct gcgagcccgc cgtgcccttc ccctgcggcc gggtgagcgt gagccagacc 420
agcaagctga cccgggccga gaccgtgttc cccgacgtgg actacgtgaa cagcaccgag 480
gccgagacca tcctggacaa catcacccag agcacccaga gcttcaacga cttcacccgg 540
gtggtgggcg gcgaggacgc caagcccggc cagttcccct ggcaggtggt gctgaacggc 600
aaggtggacg ccttctgcgg cggcagcatc gtgaacgaga agtggatcgt gaccgccgcc 660
cactgcgtgg agaccggcgt gaagatcacc gtggtggccg gcgagcacaa catcgaggag 720
accgagcaca ccgagcagaa gcggaacgtg atccggatca tcccccacca caactacaac 780
gccgccatca acaagtacaa ccacgacatc gccctgctgg agctggacga gcccctggtg 840
ctgaacagct acgtgacccc catctgcatc gccgacaagg agtacaccaa catcttcctg 900
aagttcggca gcggctacgt gagcggctgg ggccgggtgt tccacaaggg ccggagcgcc 960
ctggtgctgc agtacctgcg ggtgcccctg gtggaccggg ccacctgcct gctgagcacc 1020
aagttcacca tctacaacaa catgttctgc gccggcttcc acgagggcgg ccgggacagc 1080
tgccagggcg acagcggcgg cccccacgtg accgaggtgg agggcaccag cttcctgacc 1140
ggcatcatca gctggggcga ggagtgcgcc atgaagggca agtacggcat ctacaccaag 1200
gtgagccggt acgtgaactg gatcaaggag aagaccaagc tgacc                 1245

<210> 527
<211> 1296
<212> DNA
<213> Artificial Sequence

<220> 
<223> hWT-FIX codon optimized for human 0.5 optimization

<400> 527
gtgtttctgg atcatgaaaa cgccaacaaa attctgaatc ggccaaagag gtataattca 60
ggcaaactgg aagagtttgt gcaggggaac ctggagagag aatgtatgga agaaaagtgt 120
agttttgaag aagcacgaga agtgtttgaa aacactgaaa gaacaactga attttggaag 180
cagtatgtgg atggagatca gtgtgagtcc aatccatgtc tgaatggcgg cagttgcaag 240
gatgacatta attcctatga atgttggtgt ccctttggat ttgaaggaaa gaactgtgaa 300
ctggatgtga catgtaacat taagaatggc agatgcgagc agttttgtaa aaatagtgct 360
gataacaagg tggtgtgctc ctgtactgag ggatatcgac tggcagaaaa ccagaagtcc 420
tgtgaaccag cagtgccatt tccatgtgga agagtgtctg tgtcacagac ttctaagctg 480
acccgggctg agactgtgtt tcctgatgtg gactatgtga attctactga agctgaaacc 540
attctggata acatcactca gagcacccag tcatttaatg acttcactcg ggtggtgggc 600
ggagaagatg ccaaaccagg ccagttccct tggcaggtgg tgctgaatgg caaagtggat 660
gcattctgtg gaggctctat cgtgaatgaa aaatggattg tgactgctgc ccactgtgtg 720
gaaactggcg tgaaaattac agtggtcgca ggcgaacata atattgagga gacagaacat 780
acagagcaga agcgaaatgt gattcgaatt attcctcacc acaactacaa tgcagctatt 840
aataagtaca accatgacat tgccctgctg gaactggacg aacccctggt gctgaacagc 900
tacgtgacac ctatttgcat tgctgacaag gaatacacca acatcttcct gaaatttgga 960
tctggctatg tgagtggctg gggaagagtc ttccacaaag ggagatcagc tctggtgctg 1020
cagtacctga gagtgccact ggtggaccga gccacatgtc tgcgatctac aaagttcacc 1080
atctataaca acatgttctg tgctggcttc catgaaggag gcagagattc atgtcaggga 1140
gatagtgggg gaccccatgt gactgaagtg gaagggacca gtttcctgac tggaattatt 1200
agctggggcg aagagtgtgc aatgaaaggc aaatatggaa tctataccaa ggtgtcccgg 1260
tatgtcaact ggattaagga aaaaacaaag ctgact                           1296

<210> 528
<211> 1296
<212> DNA
<213> Artificial Sequence

<220> 
<223> hWT-FIX codon optimized for human 0.8 optimization

<400> 528
gtgtttctgg atcacgagaa cgccaacaag atcctgaatc ggccaaagag gtacaatagc 60
ggcaagctgg aggagtttgt gcagggcaac ctggagagag agtgtatgga ggagaagtgt 120
agctttgagg aggcccggga ggtgtttgag aacaccgaga gaaccaccga gttttggaag 180
cagtacgtgg atggcgatca gtgtgagtcc aatccatgtc tgaatggcgg cagctgcaag 240
gatgacatca attcctacga gtgttggtgt ccctttggct ttgagggcaa gaactgtgag 300
ctggatgtga cctgtaacat caagaatggc agatgcgagc agttttgtaa gaatagcgcc 360
gataacaagg tggtgtgctc ctgtaccgag ggctaccggc tggccgagaa ccagaagtcc 420
tgtgagccag ccgtgccatt tccatgtggc agagtgagcg tgagccagac cagcaagctg 480
acccgggccg agaccgtgtt tcctgatgtg gactacgtga atagcaccga ggccgagacc 540
atcctggata acatcaccca gagcacccag agctttaatg acttcacccg ggtggtgggc 600
ggcgaggatg ccaagccagg ccagttccct tggcaggtgg tgctgaatgg caaggtggat 660
gccttctgtg gcggcagcat cgtgaatgag aagtggatcg tgaccgccgc ccactgtgtg 720
gagaccggcg tgaagatcac cgtggtggcc ggcgagcaca atatcgagga gaccgagcac 780
accgagcaga agcggaatgt gatccggatc atccctcacc acaactacaa tgccgccatc 840
aataagtaca accacgacat cgccctgctg gagctggacg agcccctggt gctgaacagc 900
tacgtgaccc ctatctgcat cgccgacaag gagtacacca acatcttcct gaagtttggc 960
agcggctacg tgagcggctg gggcagagtg ttccacaagg gcagaagcgc cctggtgctg 1020
cagtacctga gagtgccact ggtggaccgg gccacctgtc tgcggagcac caagttcacc 1080
atctacaaca acatgttctg tgccggcttc cacgagggcg gcagagatag ctgtcagggc 1140
gatagcggcg gcccccacgt gaccgaggtg gagggcacca gcttcctgac cggcatcatc 1200
agctggggcg aggagtgtgc catgaagggc aagtacggca tctacaccaa ggtgtcccgg 1260
tacgtgaact ggatcaagga gaagaccaag ctgacc                           1296

<210> 529
<211> 1296
<212> DNA
<213> Artificial Sequence

<220> 
<223> hWT-FIX codon optimized for human 1.0 optimization

<400> 529
gtgttcctgg accacgagaa cgccaacaag atcctgaacc ggcccaagcg gtacaacagc 60
ggcaagctgg aggagttcgt gcagggcaac ctggagcggg agtgcatgga ggagaagtgc 120
agcttcgagg aggcccggga ggtgttcgag aacaccgagc ggaccaccga gttctggaag 180
cagtacgtgg acggcgacca gtgcgagagc aacccctgcc tgaacggcgg cagctgcaag 240
gacgacatca acagctacga gtgctggtgc cccttcggct tcgagggcaa gaactgcgag 300
ctggacgtga cctgcaacat caagaacggc cggtgcgagc agttctgcaa gaacagcgcc 360
gacaacaagg tggtgtgcag ctgcaccgag ggctaccggc tggccgagaa ccagaagagc 420
tgcgagcccg ccgtgccctt cccctgcggc cgggtgagcg tgagccagac cagcaagctg 480
acccgggccg agaccgtgtt ccccgacgtg gactacgtga acagcaccga ggccgagacc 540
atcctggaca acatcaccca gagcacccag agcttcaacg acttcacccg ggtggtgggc 600
ggcgaggacg ccaagcccgg ccagttcccc tggcaggtgg tgctgaacgg caaggtggac 660
gccttctgcg gcggcagcat cgtgaacgag aagtggatcg tgaccgccgc ccactgcgtg 720
gagaccggcg tgaagatcac cgtggtggcc ggcgagcaca acatcgagga gaccgagcac 780
accgagcaga agcggaacgt gatccggatc atcccccacc acaactacaa cgccgccatc 840
aacaagtaca accacgacat cgccctgctg gagctggacg agcccctggt gctgaacagc 900
tacgtgaccc ccatctgcat cgccgacaag gagtacacca acatcttcct gaagttcggc 960
agcggctacg tgagcggctg gggccgggtg ttccacaagg gccggagcgc cctggtgctg 1020
cagtacctgc gggtgcccct ggtggaccgg gccacctgcc tgcggagcac caagttcacc 1080
atctacaaca acatgttctg cgccggcttc cacgagggcg gccgggacag ctgccagggc 1140
gacagcggcg gcccccacgt gaccgaggtg gagggcacca gcttcctgac cggcatcatc 1200
agctggggcg aggagtgcgc catgaagggc aagtacggca tctacaccaa ggtgagccgg 1260
tacgtgaact ggatcaagga gaagaccaag ctgacc                           1296

<210> 530
<211> 1296
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX R318Y/R338E/T343R -FIX codon optimized
      for human 0.5 optimization

<400> 530
gtgtttctgg atcatgaaaa cgccaacaaa attctgaatc ggccaaagag gtataattca 60
ggcaaactgg aagagtttgt gcaggggaac ctggagagag aatgtatgga agaaaagtgt 120
agttttgaag aagcacgaga agtgtttgaa aacactgaaa gaacaactga attttggaag 180
cagtatgtgg atggagatca gtgtgagtcc aatccatgtc tgaatggcgg cagttgcaag 240
gatgacatta attcctatga atgttggtgt ccctttggat ttgaaggaaa gaactgtgaa 300
ctggatgtga catgtaacat taagaatggc agatgcgagc agttttgtaa aaatagtgct 360
gataacaagg tggtgtgctc ctgtactgag ggatatcgac tggcagaaaa ccagaagtcc 420
tgtgaaccag cagtgccatt tccatgtgga agagtgtctg tgtcacagac ttctaagctg 480
acccgggctg agactgtgtt tcctgatgtg gactatgtga attctactga agctgaaacc 540
attctggata acatcactca gagcacccag tcatttaatg acttcactcg ggtggtgggc 600
ggagaagatg ccaaaccagg ccagttccct tggcaggtgg tgctgaatgg caaagtggat 660
gcattctgtg gaggctctat cgtgaatgaa aaatggattg tgactgctgc ccactgtgtg 720
gaaactggcg tgaaaattac agtggtcgca ggcgaacata atattgagga gacagaacat 780
acagagcaga agcgaaatgt gattcgaatt attcctcacc acaactacaa tgcagctatt 840
aataagtaca accatgacat tgccctgctg gaactggacg aacccctggt gctgaacagc 900
tacgtgacac ctatttgcat tgctgacaag gaatacacca acatcttcct gaaatttgga 960
tctggctatg tgagtggctg gggaagagtc ttccacaaag ggtactcagc tctggtgctg 1020
cagtacctga gagtgccact ggtggaccga gccacatgtc tggagtctac aaagttccgg 1080
atctataaca acatgttctg tgctggcttc catgaaggag gcagagattc atgtcaggga 1140
gatagtgggg gaccccatgt gactgaagtg gaagggacca gtttcctgac tggaattatt 1200
agctggggcg aagagtgtgc aatgaaaggc aaatatggaa tctataccaa ggtgtcccgg 1260
tatgtcaact ggattaagga aaaaacaaag ctgact                           1296

<210> 531
<211> 1296
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX R318Y/R338E/T343R -FIX codon optimized
      for human 0.8 optimization

<400> 531
gtgtttctgg atcacgagaa cgccaacaag atcctgaatc ggccaaagag gtacaatagc 60
ggcaagctgg aggagtttgt gcagggcaac ctggagagag agtgtatgga ggagaagtgt 120
agctttgagg aggcccggga ggtgtttgag aacaccgaga gaaccaccga gttttggaag 180
cagtacgtgg atggcgatca gtgtgagtcc aatccatgtc tgaatggcgg cagctgcaag 240
gatgacatca attcctacga gtgttggtgt ccctttggct ttgagggcaa gaactgtgag 300
ctggatgtga cctgtaacat caagaatggc agatgcgagc agttttgtaa gaatagcgcc 360
gataacaagg tggtgtgctc ctgtaccgag ggctaccggc tggccgagaa ccagaagtcc 420
tgtgagccag ccgtgccatt tccatgtggc agagtgagcg tgagccagac cagcaagctg 480
acccgggccg agaccgtgtt tcctgatgtg gactacgtga atagcaccga ggccgagacc 540
atcctggata acatcaccca gagcacccag agctttaatg acttcacccg ggtggtgggc 600
ggcgaggatg ccaagccagg ccagttccct tggcaggtgg tgctgaatgg caaggtggat 660
gccttctgtg gcggcagcat cgtgaatgag aagtggatcg tgaccgccgc ccactgtgtg 720
gagaccggcg tgaagatcac cgtggtggcc ggcgagcaca atatcgagga gaccgagcac 780
accgagcaga agcggaatgt gatccggatc atccctcacc acaactacaa tgccgccatc 840
aataagtaca accacgacat cgccctgctg gagctggacg agcccctggt gctgaacagc 900
tacgtgaccc ctatctgcat cgccgacaag gagtacacca acatcttcct gaagtttggc 960
agcggctacg tgagcggctg gggcagagtg ttccacaagg gctacagcgc cctggtgctg 1020
cagtacctga gagtgccact ggtggaccgg gccacctgtc tggagagcac caagttccgg 1080
atctacaaca acatgttctg tgccggcttc cacgagggcg gcagagatag ctgtcagggc 1140
gatagcggcg gcccccacgt gaccgaggtg gagggcacca gcttcctgac cggcatcatc 1200
agctggggcg aggagtgtgc catgaagggc aagtacggca tctacaccaa ggtgtcccgg 1260
tacgtgaact ggatcaagga gaagaccaag ctgacc                           1296

<210> 532
<211> 1296
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX R318Y/R338E/T343R -FIX codon optimized
      for human 1.0 optimization

<400> 532
gtgttcctgg accacgagaa cgccaacaag atcctgaacc ggcccaagcg gtacaacagc 60
ggcaagctgg aggagttcgt gcagggcaac ctggagcggg agtgcatgga ggagaagtgc 120
agcttcgagg aggcccggga ggtgttcgag aacaccgagc ggaccaccga gttctggaag 180
cagtacgtgg acggcgacca gtgcgagagc aacccctgcc tgaacggcgg cagctgcaag 240
gacgacatca acagctacga gtgctggtgc cccttcggct tcgagggcaa gaactgcgag 300
ctggacgtga cctgcaacat caagaacggc cggtgcgagc agttctgcaa gaacagcgcc 360
gacaacaagg tggtgtgcag ctgcaccgag ggctaccggc tggccgagaa ccagaagagc 420
tgcgagcccg ccgtgccctt cccctgcggc cgggtgagcg tgagccagac cagcaagctg 480
acccgggccg agaccgtgtt ccccgacgtg gactacgtga acagcaccga ggccgagacc 540
atcctggaca acatcaccca gagcacccag agcttcaacg acttcacccg ggtggtgggc 600
ggcgaggacg ccaagcccgg ccagttcccc tggcaggtgg tgctgaacgg caaggtggac 660
gccttctgcg gcggcagcat cgtgaacgag aagtggatcg tgaccgccgc ccactgcgtg 720
gagaccggcg tgaagatcac cgtggtggcc ggcgagcaca acatcgagga gaccgagcac 780
accgagcaga agcggaacgt gatccggatc atcccccacc acaactacaa cgccgccatc 840
aacaagtaca accacgacat cgccctgctg gagctggacg agcccctggt gctgaacagc 900
tacgtgaccc ccatctgcat cgccgacaag gagtacacca acatcttcct gaagttcggc 960
agcggctacg tgagcggctg gggccgggtg ttccacaagg gctacagcgc cctggtgctg 1020
cagtacctgc gggtgcccct ggtggaccgg gccacctgcc tggagagcac caagttccgg 1080
atctacaaca acatgttctg cgccggcttc cacgagggcg gccgggacag ctgccagggc 1140
gacagcggcg gcccccacgt gaccgaggtg gagggcacca gcttcctgac cggcatcatc 1200
agctggggcg aggagtgcgc catgaagggc aagtacggca tctacaccaa ggtgagccgg 1260
tacgtgaact ggatcaagga gaagaccaag ctgacc                           1296

<210> 533
<211> 1296
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX R338L-FIX codon optimized for human 0.5
      optimization

<400> 533
gtgtttctgg atcatgaaaa cgccaacaaa attctgaatc ggccaaagag gtataattca 60
ggcaaactgg aagagtttgt gcaggggaac ctggagagag aatgtatgga agaaaagtgt 120
agttttgaag aagcacgaga agtgtttgaa aacactgaaa gaacaactga attttggaag 180
cagtatgtgg atggagatca gtgtgagtcc aatccatgtc tgaatggcgg cagttgcaag 240
gatgacatta attcctatga atgttggtgt ccctttggat ttgaaggaaa gaactgtgaa 300
ctggatgtga catgtaacat taagaatggc agatgcgagc agttttgtaa aaatagtgct 360
gataacaagg tggtgtgctc ctgtactgag ggatatcgac tggcagaaaa ccagaagtcc 420
tgtgaaccag cagtgccatt tccatgtgga agagtgtctg tgtcacagac ttctaagctg 480
acccgggctg agactgtgtt tcctgatgtg gactatgtga attctactga agctgaaacc 540
attctggata acatcactca gagcacccag tcatttaatg acttcactcg ggtggtgggc 600
ggagaagatg ccaaaccagg ccagttccct tggcaggtgg tgctgaatgg caaagtggat 660
gcattctgtg gaggctctat cgtgaatgaa aaatggattg tgactgctgc ccactgtgtg 720
gaaactggcg tgaaaattac agtggtcgca ggcgaacata atattgagga gacagaacat 780
acagagcaga agcgaaatgt gattcgaatt attcctcacc acaactacaa tgcagctatt 840
aataagtaca accatgacat tgccctgctg gaactggacg aacccctggt gctgaacagc 900
tacgtgacac ctatttgcat tgctgacaag gaatacacca acatcttcct gaaatttgga 960
tctggctatg tgagtggctg gggaagagtc ttccacaaag ggagatcagc tctggtgctg 1020
cagtacctga gagtgccact ggtggaccga gccacatgtc tgctgtctac aaagttcacc 1080
atctataaca acatgttctg tgctggcttc catgaaggag gcagagattc atgtcaggga 1140
gatagtgggg gaccccatgt gactgaagtg gaagggacca gtttcctgac tggaattatt 1200
agctggggcg aagagtgtgc aatgaaaggc aaatatggaa tctataccaa ggtgtcccgg 1260
tatgtcaact ggattaagga aaaaacaaag ctgact                           1296

<210> 534
<211> 1296
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX R338L-FIX codon optimized for human 0.8
      optimization

<400> 534
gtgtttctgg atcacgagaa cgccaacaag atcctgaatc ggccaaagag gtacaatagc 60
ggcaagctgg aggagtttgt gcagggcaac ctggagagag agtgtatgga ggagaagtgt 120
agctttgagg aggcccggga ggtgtttgag aacaccgaga gaaccaccga gttttggaag 180
cagtacgtgg atggcgatca gtgtgagtcc aatccatgtc tgaatggcgg cagctgcaag 240
gatgacatca attcctacga gtgttggtgt ccctttggct ttgagggcaa gaactgtgag 300
ctggatgtga cctgtaacat caagaatggc agatgcgagc agttttgtaa gaatagcgcc 360
gataacaagg tggtgtgctc ctgtaccgag ggctaccggc tggccgagaa ccagaagtcc 420
tgtgagccag ccgtgccatt tccatgtggc agagtgagcg tgagccagac cagcaagctg 480
acccgggccg agaccgtgtt tcctgatgtg gactacgtga atagcaccga ggccgagacc 540
atcctggata acatcaccca gagcacccag agctttaatg acttcacccg ggtggtgggc 600
ggcgaggatg ccaagccagg ccagttccct tggcaggtgg tgctgaatgg caaggtggat 660
gccttctgtg gcggcagcat cgtgaatgag aagtggatcg tgaccgccgc ccactgtgtg 720
gagaccggcg tgaagatcac cgtggtggcc ggcgagcaca atatcgagga gaccgagcac 780
accgagcaga agcggaatgt gatccggatc atccctcacc acaactacaa tgccgccatc 840
aataagtaca accacgacat cgccctgctg gagctggacg agcccctggt gctgaacagc 900
tacgtgaccc ctatctgcat cgccgacaag gagtacacca acatcttcct gaagtttggc 960
agcggctacg tgagcggctg gggcagagtg ttccacaagg gcagaagcgc cctggtgctg 1020
cagtacctga gagtgccact ggtggaccgg gccacctgtc tgctgagcac caagttcacc 1080
atctacaaca acatgttctg tgccggcttc cacgagggcg gcagagatag ctgtcagggc 1140
gatagcggcg gcccccacgt gaccgaggtg gagggcacca gcttcctgac cggcatcatc 1200
agctggggcg aggagtgtgc catgaagggc aagtacggca tctacaccaa ggtgtcccgg 1260
tacgtgaact ggatcaagga gaagaccaag ctgacc                           1296

<210> 535
<211> 1296
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX R338L-FIX codon optimized for human 1.0
      optimization

<400> 535
gtgttcctgg accacgagaa cgccaacaag atcctgaacc ggcccaagcg gtacaacagc 60
ggcaagctgg aggagttcgt gcagggcaac ctggagcggg agtgcatgga ggagaagtgc 120
agcttcgagg aggcccggga ggtgttcgag aacaccgagc ggaccaccga gttctggaag 180
cagtacgtgg acggcgacca gtgcgagagc aacccctgcc tgaacggcgg cagctgcaag 240
gacgacatca acagctacga gtgctggtgc cccttcggct tcgagggcaa gaactgcgag 300
ctggacgtga cctgcaacat caagaacggc cggtgcgagc agttctgcaa gaacagcgcc 360
gacaacaagg tggtgtgcag ctgcaccgag ggctaccggc tggccgagaa ccagaagagc 420
tgcgagcccg ccgtgccctt cccctgcggc cgggtgagcg tgagccagac cagcaagctg 480
acccgggccg agaccgtgtt ccccgacgtg gactacgtga acagcaccga ggccgagacc 540
atcctggaca acatcaccca gagcacccag agcttcaacg acttcacccg ggtggtgggc 600
ggcgaggacg ccaagcccgg ccagttcccc tggcaggtgg tgctgaacgg caaggtggac 660
gccttctgcg gcggcagcat cgtgaacgag aagtggatcg tgaccgccgc ccactgcgtg 720
gagaccggcg tgaagatcac cgtggtggcc ggcgagcaca acatcgagga gaccgagcac 780
accgagcaga agcggaacgt gatccggatc atcccccacc acaactacaa cgccgccatc 840
aacaagtaca accacgacat cgccctgctg gagctggacg agcccctggt gctgaacagc 900
tacgtgaccc ccatctgcat cgccgacaag gagtacacca acatcttcct gaagttcggc 960
agcggctacg tgagcggctg gggccgggtg ttccacaagg gccggagcgc cctggtgctg 1020
cagtacctgc gggtgcccct ggtggaccgg gccacctgcc tgctgagcac caagttcacc 1080
atctacaaca acatgttctg cgccggcttc cacgagggcg gccgggacag ctgccagggc 1140
gacagcggcg gcccccacgt gaccgaggtg gagggcacca gcttcctgac cggcatcatc 1200
agctggggcg aggagtgcgc catgaagggc aagtacggca tctacaccaa ggtgagccgg 1260
tacgtgaact ggatcaagga gaagaccaag ctgacc                           1296

<210> 536
<211> 2821
<212> DNA
<213> Artificial Sequence

<220> 
<223> hFIXss-Pro-mini Intron-Pro-human wild type FIX
      optimized 0.5

<400> 536
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta 60
ggatatctac tcagtgctga atgtacaggt ttgtttcctt ttttaaaata cattgagtat 120
gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat 180
gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactggttc 240
tttgttagct aggttttctt cttcttcatt tttaaaacta aatagatcga caatgcttat 300
gatgcattta tgtttaataa acactgttca gttcatgatt tggtcatgta attcctgtta 360
gaaaacattc atctccttgg tttaaaaaaa ttaaaagtgg gaaaacaaag aaatagcaga 420
atatagtgaa aaaaaataac cacattattt ttgtttggac ttaccacttt gaaatcaaaa 480
tgggaaacaa aagcacaaac aatggcctta tttacacaaa aagtctgatt ttaagatata 540
tgacatttca aggtttcaga agtatgtaat gaggtgtgtc tctaattttt taaattatat 600
atcttcaatt taaagtttta gttaaaacat aaagattaac ctttcattag caagctgtta 660
gttatcacca aagcttttca tggattagga aaaaatcatt ttgtctctat gtcaaacatc 720
ttggagttga tatttgggga aacacaatac tcagttgagt tccctagggg agaaaagcaa 780
gcttaagaat tgacataaag agtaggaagt tagctaatgc aacatatatc actttgtttt 840
ttcacaacta cagtgacttt atgtatttcc cagaggaagg catacaggga agaaattatc 900
ccatttggac aaacagcatg ttctcacagg aagcatttat cacacttact tgtcaacttt 960
ctagaatcaa atctagtagc tgacagtacc aggatcaggg gtgccaaccc taagcacccc 1020
cagaaagctg actggccctg tggttcccac tccagacatg atgtcagctg tgaaatcgac 1080
gtcgctggac cataattagg cttctgttct tcaggagaca tttgttcaaa gtcatttggg 1140
caaccatatt ctgaaaacag cccagccagg gtgatggatc actttgcaaa gatcctcaat 1200
gagctatttt caagtgatga caaagtgtga agttaaccgc tcatttgaga actttctttt 1260
tcatccaaag taaattcaaa tatgattaga aatctgacct tttattactg gaattctctt 1320
gactaaaagt aaaattgaat tttaattcct aaatctccat gtgtatacag tactgtggga 1380
acatcacaga ttttggctcc atgccctaaa gagaaattgg ctttcagatt atttggatta 1440
aaaacaaaga ctttcttaag agatgtaaaa ttttcatgat gttttctttt ttgctaaaac 1500
taaagaatta ttcttttaca tttcagtgtt tctggatcat gaaaacgcca acaaaattct 1560
gaatcggcca aagaggtata attcaggcaa actggaagag tttgtgcagg ggaacctgga 1620
gagagaatgt atggaagaaa agtgtagttt tgaagaagca cgagaagtgt ttgaaaacac 1680
tgaaagaaca actgaatttt ggaagcagta tgtggatgga gatcagtgtg agtccaatcc 1740
atgtctgaat ggcggcagtt gcaaggatga cattaattcc tatgaatgtt ggtgtccctt 1800
tggatttgaa ggaaagaact gtgaactgga tgtgacatgt aacattaaga atggcagatg 1860
cgagcagttt tgtaaaaata gtgctgataa caaggtggtg tgctcctgta ctgagggata 1920
tcgactggca gaaaaccaga agtcctgtga accagcagtg ccatttccat gtggaagagt 1980
gtctgtgtca cagacttcta agctgacccg ggctgagact gtgtttcctg atgtggacta 2040
tgtgaattct actgaagctg aaaccattct ggataacatc actcagagca cccagtcatt 2100
taatgacttc actcgggtgg tgggcggaga agatgccaaa ccaggccagt tcccttggca 2160
ggtggtgctg aatggcaaag tggatgcatt ctgtggaggc tctatcgtga atgaaaaatg 2220
gattgtgact gctgcccact gtgtggaaac tggcgtgaaa attacagtgg tcgcaggcga 2280
acataatatt gaggagacag aacatacaga gcagaagcga aatgtgattc gaattattcc 2340
tcaccacaac tacaatgcag ctattaataa gtacaaccat gacattgccc tgctggaact 2400
ggacgaaccc ctggtgctga acagctacgt gacacctatt tgcattgctg acaaggaata 2460
caccaacatc ttcctgaaat ttggatctgg ctatgtgagt ggctggggaa gagtcttcca 2520
caaagggaga tcagctctgg tgctgcagta cctgagagtg ccactggtgg accgagccac 2580
atgtctgcga tctacaaagt tcaccatcta taacaacatg ttctgtgctg gcttccatga 2640
aggaggcaga gattcatgtc agggagatag tgggggaccc catgtgactg aagtggaagg 2700
gaccagtttc ctgactggaa ttattagctg gggcgaagag tgtgcaatga aaggcaaata 2760
tggaatctat accaaggtgt cccggtatgt caactggatt aaggaaaaaa caaagctgac 2820
t                                                                 2821

<210> 537
<211> 2821
<212> DNA
<213> Artificial Sequence

<220> 
<223> hFIXss-Pro-mini Intron-Pro-human wild type FIX
      optimized 0.8

<400> 537
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta 60
ggatatctac tcagtgctga atgtacaggt ttgtttcctt ttttaaaata cattgagtat 120
gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat 180
gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactggttc 240
tttgttagct aggttttctt cttcttcatt tttaaaacta aatagatcga caatgcttat 300
gatgcattta tgtttaataa acactgttca gttcatgatt tggtcatgta attcctgtta 360
gaaaacattc atctccttgg tttaaaaaaa ttaaaagtgg gaaaacaaag aaatagcaga 420
atatagtgaa aaaaaataac cacattattt ttgtttggac ttaccacttt gaaatcaaaa 480
tgggaaacaa aagcacaaac aatggcctta tttacacaaa aagtctgatt ttaagatata 540
tgacatttca aggtttcaga agtatgtaat gaggtgtgtc tctaattttt taaattatat 600
atcttcaatt taaagtttta gttaaaacat aaagattaac ctttcattag caagctgtta 660
gttatcacca aagcttttca tggattagga aaaaatcatt ttgtctctat gtcaaacatc 720
ttggagttga tatttgggga aacacaatac tcagttgagt tccctagggg agaaaagcaa 780
gcttaagaat tgacataaag agtaggaagt tagctaatgc aacatatatc actttgtttt 840
ttcacaacta cagtgacttt atgtatttcc cagaggaagg catacaggga agaaattatc 900
ccatttggac aaacagcatg ttctcacagg aagcatttat cacacttact tgtcaacttt 960
ctagaatcaa atctagtagc tgacagtacc aggatcaggg gtgccaaccc taagcacccc 1020
cagaaagctg actggccctg tggttcccac tccagacatg atgtcagctg tgaaatcgac 1080
gtcgctggac cataattagg cttctgttct tcaggagaca tttgttcaaa gtcatttggg 1140
caaccatatt ctgaaaacag cccagccagg gtgatggatc actttgcaaa gatcctcaat 1200
gagctatttt caagtgatga caaagtgtga agttaaccgc tcatttgaga actttctttt 1260
tcatccaaag taaattcaaa tatgattaga aatctgacct tttattactg gaattctctt 1320
gactaaaagt aaaattgaat tttaattcct aaatctccat gtgtatacag tactgtggga 1380
acatcacaga ttttggctcc atgccctaaa gagaaattgg ctttcagatt atttggatta 1440
aaaacaaaga ctttcttaag agatgtaaaa ttttcatgat gttttctttt ttgctaaaac 1500
taaagaatta ttcttttaca tttcagtgtt tctggatcac gagaacgcca acaagatcct 1560
gaatcggcca aagaggtaca atagcggcaa gctggaggag tttgtgcagg gcaacctgga 1620
gagagagtgt atggaggaga agtgtagctt tgaggaggcc cgggaggtgt ttgagaacac 1680
cgagagaacc accgagtttt ggaagcagta cgtggatggc gatcagtgtg agtccaatcc 1740
atgtctgaat ggcggcagct gcaaggatga catcaattcc tacgagtgtt ggtgtccctt 1800
tggctttgag ggcaagaact gtgagctgga tgtgacctgt aacatcaaga atggcagatg 1860
cgagcagttt tgtaagaata gcgccgataa caaggtggtg tgctcctgta ccgagggcta 1920
ccggctggcc gagaaccaga agtcctgtga gccagccgtg ccatttccat gtggcagagt 1980
gagcgtgagc cagaccagca agctgacccg ggccgagacc gtgtttcctg atgtggacta 2040
cgtgaatagc accgaggccg agaccatcct ggataacatc acccagagca cccagagctt 2100
taatgacttc acccgggtgg tgggcggcga ggatgccaag ccaggccagt tcccttggca 2160
ggtggtgctg aatggcaagg tggatgcctt ctgtggcggc agcatcgtga atgagaagtg 2220
gatcgtgacc gccgcccact gtgtggagac cggcgtgaag atcaccgtgg tggccggcga 2280
gcacaatatc gaggagaccg agcacaccga gcagaagcgg aatgtgatcc ggatcatccc 2340
tcaccacaac tacaatgccg ccatcaataa gtacaaccac gacatcgccc tgctggagct 2400
ggacgagccc ctggtgctga acagctacgt gacccctatc tgcatcgccg acaaggagta 2460
caccaacatc ttcctgaagt ttggcagcgg ctacgtgagc ggctggggca gagtgttcca 2520
caagggcaga agcgccctgg tgctgcagta cctgagagtg ccactggtgg accgggccac 2580
ctgtctgcgg agcaccaagt tcaccatcta caacaacatg ttctgtgccg gcttccacga 2640
gggcggcaga gatagctgtc agggcgatag cggcggcccc cacgtgaccg aggtggaggg 2700
caccagcttc ctgaccggca tcatcagctg gggcgaggag tgtgccatga agggcaagta 2760
cggcatctac accaaggtgt cccggtacgt gaactggatc aaggagaaga ccaagctgac 2820
c                                                                 2821

<210> 538
<211> 2821
<212> DNA
<213> Artificial Sequence

<220> 
<223> hFIXss-Pro-mini Intron-Pro-human wild type FIX
      optimized 1.0

<400> 538
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta 60
ggatatctac tcagtgctga atgtacaggt ttgtttcctt ttttaaaata cattgagtat 120
gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat 180
gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactggttc 240
tttgttagct aggttttctt cttcttcatt tttaaaacta aatagatcga caatgcttat 300
gatgcattta tgtttaataa acactgttca gttcatgatt tggtcatgta attcctgtta 360
gaaaacattc atctccttgg tttaaaaaaa ttaaaagtgg gaaaacaaag aaatagcaga 420
atatagtgaa aaaaaataac cacattattt ttgtttggac ttaccacttt gaaatcaaaa 480
tgggaaacaa aagcacaaac aatggcctta tttacacaaa aagtctgatt ttaagatata 540
tgacatttca aggtttcaga agtatgtaat gaggtgtgtc tctaattttt taaattatat 600
atcttcaatt taaagtttta gttaaaacat aaagattaac ctttcattag caagctgtta 660
gttatcacca aagcttttca tggattagga aaaaatcatt ttgtctctat gtcaaacatc 720
ttggagttga tatttgggga aacacaatac tcagttgagt tccctagggg agaaaagcaa 780
gcttaagaat tgacataaag agtaggaagt tagctaatgc aacatatatc actttgtttt 840
ttcacaacta cagtgacttt atgtatttcc cagaggaagg catacaggga agaaattatc 900
ccatttggac aaacagcatg ttctcacagg aagcatttat cacacttact tgtcaacttt 960
ctagaatcaa atctagtagc tgacagtacc aggatcaggg gtgccaaccc taagcacccc 1020
cagaaagctg actggccctg tggttcccac tccagacatg atgtcagctg tgaaatcgac 1080
gtcgctggac cataattagg cttctgttct tcaggagaca tttgttcaaa gtcatttggg 1140
caaccatatt ctgaaaacag cccagccagg gtgatggatc actttgcaaa gatcctcaat 1200
gagctatttt caagtgatga caaagtgtga agttaaccgc tcatttgaga actttctttt 1260
tcatccaaag taaattcaaa tatgattaga aatctgacct tttattactg gaattctctt 1320
gactaaaagt aaaattgaat tttaattcct aaatctccat gtgtatacag tactgtggga 1380
acatcacaga ttttggctcc atgccctaaa gagaaattgg ctttcagatt atttggatta 1440
aaaacaaaga ctttcttaag agatgtaaaa ttttcatgat gttttctttt ttgctaaaac 1500
taaagaatta ttcttttaca tttcagtgtt cctggaccac gagaacgcca acaagatcct 1560
gaaccggccc aagcggtaca acagcggcaa gctggaggag ttcgtgcagg gcaacctgga 1620
gcgggagtgc atggaggaga agtgcagctt cgaggaggcc cgggaggtgt tcgagaacac 1680
cgagcggacc accgagttct ggaagcagta cgtggacggc gaccagtgcg agagcaaccc 1740
ctgcctgaac ggcggcagct gcaaggacga catcaacagc tacgagtgct ggtgcccctt 1800
cggcttcgag ggcaagaact gcgagctgga cgtgacctgc aacatcaaga acggccggtg 1860
cgagcagttc tgcaagaaca gcgccgacaa caaggtggtg tgcagctgca ccgagggcta 1920
ccggctggcc gagaaccaga agagctgcga gcccgccgtg cccttcccct gcggccgggt 1980
gagcgtgagc cagaccagca agctgacccg ggccgagacc gtgttccccg acgtggacta 2040
cgtgaacagc accgaggccg agaccatcct ggacaacatc acccagagca cccagagctt 2100
caacgacttc acccgggtgg tgggcggcga ggacgccaag cccggccagt tcccctggca 2160
ggtggtgctg aacggcaagg tggacgcctt ctgcggcggc agcatcgtga acgagaagtg 2220
gatcgtgacc gccgcccact gcgtggagac cggcgtgaag atcaccgtgg tggccggcga 2280
gcacaacatc gaggagaccg agcacaccga gcagaagcgg aacgtgatcc ggatcatccc 2340
ccaccacaac tacaacgccg ccatcaacaa gtacaaccac gacatcgccc tgctggagct 2400
ggacgagccc ctggtgctga acagctacgt gacccccatc tgcatcgccg acaaggagta 2460
caccaacatc ttcctgaagt tcggcagcgg ctacgtgagc ggctggggcc gggtgttcca 2520
caagggccgg agcgccctgg tgctgcagta cctgcgggtg cccctggtgg accgggccac 2580
ctgcctgcgg agcaccaagt tcaccatcta caacaacatg ttctgcgccg gcttccacga 2640
gggcggccgg gacagctgcc agggcgacag cggcggcccc cacgtgaccg aggtggaggg 2700
caccagcttc ctgaccggca tcatcagctg gggcgaggag tgcgccatga agggcaagta 2760
cggcatctac accaaggtga gccggtacgt gaactggatc aaggagaaga ccaagctgac 2820
c                                                                 2821

<210> 539
<211> 2821
<212> DNA
<213> Artificial Sequence

<220> 
<223> hFIXss-Pro-mini Intron-Pro-human FIX
      R318Y/R338E/T343R optimized 0.5

<400> 539
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta 60
ggatatctac tcagtgctga atgtacaggt ttgtttcctt ttttaaaata cattgagtat 120
gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat 180
gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactggttc 240
tttgttagct aggttttctt cttcttcatt tttaaaacta aatagatcga caatgcttat 300
gatgcattta tgtttaataa acactgttca gttcatgatt tggtcatgta attcctgtta 360
gaaaacattc atctccttgg tttaaaaaaa ttaaaagtgg gaaaacaaag aaatagcaga 420
atatagtgaa aaaaaataac cacattattt ttgtttggac ttaccacttt gaaatcaaaa 480
tgggaaacaa aagcacaaac aatggcctta tttacacaaa aagtctgatt ttaagatata 540
tgacatttca aggtttcaga agtatgtaat gaggtgtgtc tctaattttt taaattatat 600
atcttcaatt taaagtttta gttaaaacat aaagattaac ctttcattag caagctgtta 660
gttatcacca aagcttttca tggattagga aaaaatcatt ttgtctctat gtcaaacatc 720
ttggagttga tatttgggga aacacaatac tcagttgagt tccctagggg agaaaagcaa 780
gcttaagaat tgacataaag agtaggaagt tagctaatgc aacatatatc actttgtttt 840
ttcacaacta cagtgacttt atgtatttcc cagaggaagg catacaggga agaaattatc 900
ccatttggac aaacagcatg ttctcacagg aagcatttat cacacttact tgtcaacttt 960
ctagaatcaa atctagtagc tgacagtacc aggatcaggg gtgccaaccc taagcacccc 1020
cagaaagctg actggccctg tggttcccac tccagacatg atgtcagctg tgaaatcgac 1080
gtcgctggac cataattagg cttctgttct tcaggagaca tttgttcaaa gtcatttggg 1140
caaccatatt ctgaaaacag cccagccagg gtgatggatc actttgcaaa gatcctcaat 1200
gagctatttt caagtgatga caaagtgtga agttaaccgc tcatttgaga actttctttt 1260
tcatccaaag taaattcaaa tatgattaga aatctgacct tttattactg gaattctctt 1320
gactaaaagt aaaattgaat tttaattcct aaatctccat gtgtatacag tactgtggga 1380
acatcacaga ttttggctcc atgccctaaa gagaaattgg ctttcagatt atttggatta 1440
aaaacaaaga ctttcttaag agatgtaaaa ttttcatgat gttttctttt ttgctaaaac 1500
taaagaatta ttcttttaca tttcagtgtt tctggatcat gaaaacgcca acaaaattct 1560
gaatcggcca aagaggtata attcaggcaa actggaagag tttgtgcagg ggaacctgga 1620
gagagaatgt atggaagaaa agtgtagttt tgaagaagca cgagaagtgt ttgaaaacac 1680
tgaaagaaca actgaatttt ggaagcagta tgtggatgga gatcagtgtg agtccaatcc 1740
atgtctgaat ggcggcagtt gcaaggatga cattaattcc tatgaatgtt ggtgtccctt 1800
tggatttgaa ggaaagaact gtgaactgga tgtgacatgt aacattaaga atggcagatg 1860
cgagcagttt tgtaaaaata gtgctgataa caaggtggtg tgctcctgta ctgagggata 1920
tcgactggca gaaaaccaga agtcctgtga accagcagtg ccatttccat gtggaagagt 1980
gtctgtgtca cagacttcta agctgacccg ggctgagact gtgtttcctg atgtggacta 2040
tgtgaattct actgaagctg aaaccattct ggataacatc actcagagca cccagtcatt 2100
taatgacttc actcgggtgg tgggcggaga agatgccaaa ccaggccagt tcccttggca 2160
ggtggtgctg aatggcaaag tggatgcatt ctgtggaggc tctatcgtga atgaaaaatg 2220
gattgtgact gctgcccact gtgtggaaac tggcgtgaaa attacagtgg tcgcaggcga 2280
acataatatt gaggagacag aacatacaga gcagaagcga aatgtgattc gaattattcc 2340
tcaccacaac tacaatgcag ctattaataa gtacaaccat gacattgccc tgctggaact 2400
ggacgaaccc ctggtgctga acagctacgt gacacctatt tgcattgctg acaaggaata 2460
caccaacatc ttcctgaaat ttggatctgg ctatgtgagt ggctggggaa gagtcttcca 2520
caaagggtac tcagctctgg tgctgcagta cctgagagtg ccactggtgg accgagccac 2580
atgtctggag tctacaaagt tccggatcta taacaacatg ttctgtgctg gcttccatga 2640
aggaggcaga gattcatgtc agggagatag tgggggaccc catgtgactg aagtggaagg 2700
gaccagtttc ctgactggaa ttattagctg gggcgaagag tgtgcaatga aaggcaaata 2760
tggaatctat accaaggtgt cccggtatgt caactggatt aaggaaaaaa caaagctgac 2820
t                                                                 2821

<210> 540
<211> 2821
<212> DNA
<213> Artificial Sequence

<220> 
<223> hFIXss-Pro-mini Intron-Pro-human FIX
      R318Y/R338E/T343R optimized 0.8

<400> 540
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta 60
ggatatctac tcagtgctga atgtacaggt ttgtttcctt ttttaaaata cattgagtat 120
gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat 180
gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactggttc 240
tttgttagct aggttttctt cttcttcatt tttaaaacta aatagatcga caatgcttat 300
gatgcattta tgtttaataa acactgttca gttcatgatt tggtcatgta attcctgtta 360
gaaaacattc atctccttgg tttaaaaaaa ttaaaagtgg gaaaacaaag aaatagcaga 420
atatagtgaa aaaaaataac cacattattt ttgtttggac ttaccacttt gaaatcaaaa 480
tgggaaacaa aagcacaaac aatggcctta tttacacaaa aagtctgatt ttaagatata 540
tgacatttca aggtttcaga agtatgtaat gaggtgtgtc tctaattttt taaattatat 600
atcttcaatt taaagtttta gttaaaacat aaagattaac ctttcattag caagctgtta 660
gttatcacca aagcttttca tggattagga aaaaatcatt ttgtctctat gtcaaacatc 720
ttggagttga tatttgggga aacacaatac tcagttgagt tccctagggg agaaaagcaa 780
gcttaagaat tgacataaag agtaggaagt tagctaatgc aacatatatc actttgtttt 840
ttcacaacta cagtgacttt atgtatttcc cagaggaagg catacaggga agaaattatc 900
ccatttggac aaacagcatg ttctcacagg aagcatttat cacacttact tgtcaacttt 960
ctagaatcaa atctagtagc tgacagtacc aggatcaggg gtgccaaccc taagcacccc 1020
cagaaagctg actggccctg tggttcccac tccagacatg atgtcagctg tgaaatcgac 1080
gtcgctggac cataattagg cttctgttct tcaggagaca tttgttcaaa gtcatttggg 1140
caaccatatt ctgaaaacag cccagccagg gtgatggatc actttgcaaa gatcctcaat 1200
gagctatttt caagtgatga caaagtgtga agttaaccgc tcatttgaga actttctttt 1260
tcatccaaag taaattcaaa tatgattaga aatctgacct tttattactg gaattctctt 1320
gactaaaagt aaaattgaat tttaattcct aaatctccat gtgtatacag tactgtggga 1380
acatcacaga ttttggctcc atgccctaaa gagaaattgg ctttcagatt atttggatta 1440
aaaacaaaga ctttcttaag agatgtaaaa ttttcatgat gttttctttt ttgctaaaac 1500
taaagaatta ttcttttaca tttcagtgtt tctggatcac gagaacgcca acaagatcct 1560
gaatcggcca aagaggtaca atagcggcaa gctggaggag tttgtgcagg gcaacctgga 1620
gagagagtgt atggaggaga agtgtagctt tgaggaggcc cgggaggtgt ttgagaacac 1680
cgagagaacc accgagtttt ggaagcagta cgtggatggc gatcagtgtg agtccaatcc 1740
atgtctgaat ggcggcagct gcaaggatga catcaattcc tacgagtgtt ggtgtccctt 1800
tggctttgag ggcaagaact gtgagctgga tgtgacctgt aacatcaaga atggcagatg 1860
cgagcagttt tgtaagaata gcgccgataa caaggtggtg tgctcctgta ccgagggcta 1920
ccggctggcc gagaaccaga agtcctgtga gccagccgtg ccatttccat gtggcagagt 1980
gagcgtgagc cagaccagca agctgacccg ggccgagacc gtgtttcctg atgtggacta 2040
cgtgaatagc accgaggccg agaccatcct ggataacatc acccagagca cccagagctt 2100
taatgacttc acccgggtgg tgggcggcga ggatgccaag ccaggccagt tcccttggca 2160
ggtggtgctg aatggcaagg tggatgcctt ctgtggcggc agcatcgtga atgagaagtg 2220
gatcgtgacc gccgcccact gtgtggagac cggcgtgaag atcaccgtgg tggccggcga 2280
gcacaatatc gaggagaccg agcacaccga gcagaagcgg aatgtgatcc ggatcatccc 2340
tcaccacaac tacaatgccg ccatcaataa gtacaaccac gacatcgccc tgctggagct 2400
ggacgagccc ctggtgctga acagctacgt gacccctatc tgcatcgccg acaaggagta 2460
caccaacatc ttcctgaagt ttggcagcgg ctacgtgagc ggctggggca gagtgttcca 2520
caagggctac agcgccctgg tgctgcagta cctgagagtg ccactggtgg accgggccac 2580
ctgtctggag agcaccaagt tccggatcta caacaacatg ttctgtgccg gcttccacga 2640
gggcggcaga gatagctgtc agggcgatag cggcggcccc cacgtgaccg aggtggaggg 2700
caccagcttc ctgaccggca tcatcagctg gggcgaggag tgtgccatga agggcaagta 2760
cggcatctac accaaggtgt cccggtacgt gaactggatc aaggagaaga ccaagctgac 2820
c                                                                 2821

<210> 541
<211> 2821
<212> DNA
<213> Artificial Sequence

<220> 
<223> hFIXss-Pro-mini Intron-Pro-human FIX
      R318Y/R338E/T343R optimized 1.0

<400> 541
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta 60
ggatatctac tcagtgctga atgtacaggt ttgtttcctt ttttaaaata cattgagtat 120
gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat 180
gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactggttc 240
tttgttagct aggttttctt cttcttcatt tttaaaacta aatagatcga caatgcttat 300
gatgcattta tgtttaataa acactgttca gttcatgatt tggtcatgta attcctgtta 360
gaaaacattc atctccttgg tttaaaaaaa ttaaaagtgg gaaaacaaag aaatagcaga 420
atatagtgaa aaaaaataac cacattattt ttgtttggac ttaccacttt gaaatcaaaa 480
tgggaaacaa aagcacaaac aatggcctta tttacacaaa aagtctgatt ttaagatata 540
tgacatttca aggtttcaga agtatgtaat gaggtgtgtc tctaattttt taaattatat 600
atcttcaatt taaagtttta gttaaaacat aaagattaac ctttcattag caagctgtta 660
gttatcacca aagcttttca tggattagga aaaaatcatt ttgtctctat gtcaaacatc 720
ttggagttga tatttgggga aacacaatac tcagttgagt tccctagggg agaaaagcaa 780
gcttaagaat tgacataaag agtaggaagt tagctaatgc aacatatatc actttgtttt 840
ttcacaacta cagtgacttt atgtatttcc cagaggaagg catacaggga agaaattatc 900
ccatttggac aaacagcatg ttctcacagg aagcatttat cacacttact tgtcaacttt 960
ctagaatcaa atctagtagc tgacagtacc aggatcaggg gtgccaaccc taagcacccc 1020
cagaaagctg actggccctg tggttcccac tccagacatg atgtcagctg tgaaatcgac 1080
gtcgctggac cataattagg cttctgttct tcaggagaca tttgttcaaa gtcatttggg 1140
caaccatatt ctgaaaacag cccagccagg gtgatggatc actttgcaaa gatcctcaat 1200
gagctatttt caagtgatga caaagtgtga agttaaccgc tcatttgaga actttctttt 1260
tcatccaaag taaattcaaa tatgattaga aatctgacct tttattactg gaattctctt 1320
gactaaaagt aaaattgaat tttaattcct aaatctccat gtgtatacag tactgtggga 1380
acatcacaga ttttggctcc atgccctaaa gagaaattgg ctttcagatt atttggatta 1440
aaaacaaaga ctttcttaag agatgtaaaa ttttcatgat gttttctttt ttgctaaaac 1500
taaagaatta ttcttttaca tttcagtgtt cctggaccac gagaacgcca acaagatcct 1560
gaaccggccc aagcggtaca acagcggcaa gctggaggag ttcgtgcagg gcaacctgga 1620
gcgggagtgc atggaggaga agtgcagctt cgaggaggcc cgggaggtgt tcgagaacac 1680
cgagcggacc accgagttct ggaagcagta cgtggacggc gaccagtgcg agagcaaccc 1740
ctgcctgaac ggcggcagct gcaaggacga catcaacagc tacgagtgct ggtgcccctt 1800
cggcttcgag ggcaagaact gcgagctgga cgtgacctgc aacatcaaga acggccggtg 1860
cgagcagttc tgcaagaaca gcgccgacaa caaggtggtg tgcagctgca ccgagggcta 1920
ccggctggcc gagaaccaga agagctgcga gcccgccgtg cccttcccct gcggccgggt 1980
gagcgtgagc cagaccagca agctgacccg ggccgagacc gtgttccccg acgtggacta 2040
cgtgaacagc accgaggccg agaccatcct ggacaacatc acccagagca cccagagctt 2100
caacgacttc acccgggtgg tgggcggcga ggacgccaag cccggccagt tcccctggca 2160
ggtggtgctg aacggcaagg tggacgcctt ctgcggcggc agcatcgtga acgagaagtg 2220
gatcgtgacc gccgcccact gcgtggagac cggcgtgaag atcaccgtgg tggccggcga 2280
gcacaacatc gaggagaccg agcacaccga gcagaagcgg aacgtgatcc ggatcatccc 2340
ccaccacaac tacaacgccg ccatcaacaa gtacaaccac gacatcgccc tgctggagct 2400
ggacgagccc ctggtgctga acagctacgt gacccccatc tgcatcgccg acaaggagta 2460
caccaacatc ttcctgaagt tcggcagcgg ctacgtgagc ggctggggcc gggtgttcca 2520
caagggctac agcgccctgg tgctgcagta cctgcgggtg cccctggtgg accgggccac 2580
ctgcctggag agcaccaagt tccggatcta caacaacatg ttctgcgccg gcttccacga 2640
gggcggccgg gacagctgcc agggcgacag cggcggcccc cacgtgaccg aggtggaggg 2700
caccagcttc ctgaccggca tcatcagctg gggcgaggag tgcgccatga agggcaagta 2760
cggcatctac accaaggtga gccggtacgt gaactggatc aaggagaaga ccaagctgac 2820
c                                                                 2821

<210> 542
<211> 2821
<212> DNA
<213> Artificial Sequence

<220> 
<223> hFIXss-Pro-mini Intron-Pro-human FIX R338L
      optimized 0.5

<400> 542
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta 60
ggatatctac tcagtgctga atgtacaggt ttgtttcctt ttttaaaata cattgagtat 120
gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat 180
gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactggttc 240
tttgttagct aggttttctt cttcttcatt tttaaaacta aatagatcga caatgcttat 300
gatgcattta tgtttaataa acactgttca gttcatgatt tggtcatgta attcctgtta 360
gaaaacattc atctccttgg tttaaaaaaa ttaaaagtgg gaaaacaaag aaatagcaga 420
atatagtgaa aaaaaataac cacattattt ttgtttggac ttaccacttt gaaatcaaaa 480
tgggaaacaa aagcacaaac aatggcctta tttacacaaa aagtctgatt ttaagatata 540
tgacatttca aggtttcaga agtatgtaat gaggtgtgtc tctaattttt taaattatat 600
atcttcaatt taaagtttta gttaaaacat aaagattaac ctttcattag caagctgtta 660
gttatcacca aagcttttca tggattagga aaaaatcatt ttgtctctat gtcaaacatc 720
ttggagttga tatttgggga aacacaatac tcagttgagt tccctagggg agaaaagcaa 780
gcttaagaat tgacataaag agtaggaagt tagctaatgc aacatatatc actttgtttt 840
ttcacaacta cagtgacttt atgtatttcc cagaggaagg catacaggga agaaattatc 900
ccatttggac aaacagcatg ttctcacagg aagcatttat cacacttact tgtcaacttt 960
ctagaatcaa atctagtagc tgacagtacc aggatcaggg gtgccaaccc taagcacccc 1020
cagaaagctg actggccctg tggttcccac tccagacatg atgtcagctg tgaaatcgac 1080
gtcgctggac cataattagg cttctgttct tcaggagaca tttgttcaaa gtcatttggg 1140
caaccatatt ctgaaaacag cccagccagg gtgatggatc actttgcaaa gatcctcaat 1200
gagctatttt caagtgatga caaagtgtga agttaaccgc tcatttgaga actttctttt 1260
tcatccaaag taaattcaaa tatgattaga aatctgacct tttattactg gaattctctt 1320
gactaaaagt aaaattgaat tttaattcct aaatctccat gtgtatacag tactgtggga 1380
acatcacaga ttttggctcc atgccctaaa gagaaattgg ctttcagatt atttggatta 1440
aaaacaaaga ctttcttaag agatgtaaaa ttttcatgat gttttctttt ttgctaaaac 1500
taaagaatta ttcttttaca tttcagtgtt tctggatcat gaaaacgcca acaaaattct 1560
gaatcggcca aagaggtata attcaggcaa actggaagag tttgtgcagg ggaacctgga 1620
gagagaatgt atggaagaaa agtgtagttt tgaagaagca cgagaagtgt ttgaaaacac 1680
tgaaagaaca actgaatttt ggaagcagta tgtggatgga gatcagtgtg agtccaatcc 1740
atgtctgaat ggcggcagtt gcaaggatga cattaattcc tatgaatgtt ggtgtccctt 1800
tggatttgaa ggaaagaact gtgaactgga tgtgacatgt aacattaaga atggcagatg 1860
cgagcagttt tgtaaaaata gtgctgataa caaggtggtg tgctcctgta ctgagggata 1920
tcgactggca gaaaaccaga agtcctgtga accagcagtg ccatttccat gtggaagagt 1980
gtctgtgtca cagacttcta agctgacccg ggctgagact gtgtttcctg atgtggacta 2040
tgtgaattct actgaagctg aaaccattct ggataacatc actcagagca cccagtcatt 2100
taatgacttc actcgggtgg tgggcggaga agatgccaaa ccaggccagt tcccttggca 2160
ggtggtgctg aatggcaaag tggatgcatt ctgtggaggc tctatcgtga atgaaaaatg 2220
gattgtgact gctgcccact gtgtggaaac tggcgtgaaa attacagtgg tcgcaggcga 2280
acataatatt gaggagacag aacatacaga gcagaagcga aatgtgattc gaattattcc 2340
tcaccacaac tacaatgcag ctattaataa gtacaaccat gacattgccc tgctggaact 2400
ggacgaaccc ctggtgctga acagctacgt gacacctatt tgcattgctg acaaggaata 2460
caccaacatc ttcctgaaat ttggatctgg ctatgtgagt ggctggggaa gagtcttcca 2520
caaagggaga tcagctctgg tgctgcagta cctgagagtg ccactggtgg accgagccac 2580
atgtctgctg tctacaaagt tcaccatcta taacaacatg ttctgtgctg gcttccatga 2640
aggaggcaga gattcatgtc agggagatag tgggggaccc catgtgactg aagtggaagg 2700
gaccagtttc ctgactggaa ttattagctg gggcgaagag tgtgcaatga aaggcaaata 2760
tggaatctat accaaggtgt cccggtatgt caactggatt aaggaaaaaa caaagctgac 2820
t                                                                 2821

<210> 543
<211> 2821
<212> DNA
<213> Artificial Sequence

<220> 
<223> hFIXss-Pro-mini Intron-Pro-human FIX R338L
      optimized 0.8

<400> 543
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta 60
ggatatctac tcagtgctga atgtacaggt ttgtttcctt ttttaaaata cattgagtat 120
gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat 180
gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactggttc 240
tttgttagct aggttttctt cttcttcatt tttaaaacta aatagatcga caatgcttat 300
gatgcattta tgtttaataa acactgttca gttcatgatt tggtcatgta attcctgtta 360
gaaaacattc atctccttgg tttaaaaaaa ttaaaagtgg gaaaacaaag aaatagcaga 420
atatagtgaa aaaaaataac cacattattt ttgtttggac ttaccacttt gaaatcaaaa 480
tgggaaacaa aagcacaaac aatggcctta tttacacaaa aagtctgatt ttaagatata 540
tgacatttca aggtttcaga agtatgtaat gaggtgtgtc tctaattttt taaattatat 600
atcttcaatt taaagtttta gttaaaacat aaagattaac ctttcattag caagctgtta 660
gttatcacca aagcttttca tggattagga aaaaatcatt ttgtctctat gtcaaacatc 720
ttggagttga tatttgggga aacacaatac tcagttgagt tccctagggg agaaaagcaa 780
gcttaagaat tgacataaag agtaggaagt tagctaatgc aacatatatc actttgtttt 840
ttcacaacta cagtgacttt atgtatttcc cagaggaagg catacaggga agaaattatc 900
ccatttggac aaacagcatg ttctcacagg aagcatttat cacacttact tgtcaacttt 960
ctagaatcaa atctagtagc tgacagtacc aggatcaggg gtgccaaccc taagcacccc 1020
cagaaagctg actggccctg tggttcccac tccagacatg atgtcagctg tgaaatcgac 1080
gtcgctggac cataattagg cttctgttct tcaggagaca tttgttcaaa gtcatttggg 1140
caaccatatt ctgaaaacag cccagccagg gtgatggatc actttgcaaa gatcctcaat 1200
gagctatttt caagtgatga caaagtgtga agttaaccgc tcatttgaga actttctttt 1260
tcatccaaag taaattcaaa tatgattaga aatctgacct tttattactg gaattctctt 1320
gactaaaagt aaaattgaat tttaattcct aaatctccat gtgtatacag tactgtggga 1380
acatcacaga ttttggctcc atgccctaaa gagaaattgg ctttcagatt atttggatta 1440
aaaacaaaga ctttcttaag agatgtaaaa ttttcatgat gttttctttt ttgctaaaac 1500
taaagaatta ttcttttaca tttcagtgtt tctggatcac gagaacgcca acaagatcct 1560
gaatcggcca aagaggtaca atagcggcaa gctggaggag tttgtgcagg gcaacctgga 1620
gagagagtgt atggaggaga agtgtagctt tgaggaggcc cgggaggtgt ttgagaacac 1680
cgagagaacc accgagtttt ggaagcagta cgtggatggc gatcagtgtg agtccaatcc 1740
atgtctgaat ggcggcagct gcaaggatga catcaattcc tacgagtgtt ggtgtccctt 1800
tggctttgag ggcaagaact gtgagctgga tgtgacctgt aacatcaaga atggcagatg 1860
cgagcagttt tgtaagaata gcgccgataa caaggtggtg tgctcctgta ccgagggcta 1920
ccggctggcc gagaaccaga agtcctgtga gccagccgtg ccatttccat gtggcagagt 1980
gagcgtgagc cagaccagca agctgacccg ggccgagacc gtgtttcctg atgtggacta 2040
cgtgaatagc accgaggccg agaccatcct ggataacatc acccagagca cccagagctt 2100
taatgacttc acccgggtgg tgggcggcga ggatgccaag ccaggccagt tcccttggca 2160
ggtggtgctg aatggcaagg tggatgcctt ctgtggcggc agcatcgtga atgagaagtg 2220
gatcgtgacc gccgcccact gtgtggagac cggcgtgaag atcaccgtgg tggccggcga 2280
gcacaatatc gaggagaccg agcacaccga gcagaagcgg aatgtgatcc ggatcatccc 2340
tcaccacaac tacaatgccg ccatcaataa gtacaaccac gacatcgccc tgctggagct 2400
ggacgagccc ctggtgctga acagctacgt gacccctatc tgcatcgccg acaaggagta 2460
caccaacatc ttcctgaagt ttggcagcgg ctacgtgagc ggctggggca gagtgttcca 2520
caagggcaga agcgccctgg tgctgcagta cctgagagtg ccactggtgg accgggccac 2580
ctgtctgctg agcaccaagt tcaccatcta caacaacatg ttctgtgccg gcttccacga 2640
gggcggcaga gatagctgtc agggcgatag cggcggcccc cacgtgaccg aggtggaggg 2700
caccagcttc ctgaccggca tcatcagctg gggcgaggag tgtgccatga agggcaagta 2760
cggcatctac accaaggtgt cccggtacgt gaactggatc aaggagaaga ccaagctgac 2820
c                                                                 2821

<210> 544
<211> 2821
<212> DNA
<213> Artificial Sequence

<220> 
<223> hFIXss-Pro-mini Intron-Pro-human FIX R338L
      optimized 1.0

<400> 544
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta 60
ggatatctac tcagtgctga atgtacaggt ttgtttcctt ttttaaaata cattgagtat 120
gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat 180
gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactggttc 240
tttgttagct aggttttctt cttcttcatt tttaaaacta aatagatcga caatgcttat 300
gatgcattta tgtttaataa acactgttca gttcatgatt tggtcatgta attcctgtta 360
gaaaacattc atctccttgg tttaaaaaaa ttaaaagtgg gaaaacaaag aaatagcaga 420
atatagtgaa aaaaaataac cacattattt ttgtttggac ttaccacttt gaaatcaaaa 480
tgggaaacaa aagcacaaac aatggcctta tttacacaaa aagtctgatt ttaagatata 540
tgacatttca aggtttcaga agtatgtaat gaggtgtgtc tctaattttt taaattatat 600
atcttcaatt taaagtttta gttaaaacat aaagattaac ctttcattag caagctgtta 660
gttatcacca aagcttttca tggattagga aaaaatcatt ttgtctctat gtcaaacatc 720
ttggagttga tatttgggga aacacaatac tcagttgagt tccctagggg agaaaagcaa 780
gcttaagaat tgacataaag agtaggaagt tagctaatgc aacatatatc actttgtttt 840
ttcacaacta cagtgacttt atgtatttcc cagaggaagg catacaggga agaaattatc 900
ccatttggac aaacagcatg ttctcacagg aagcatttat cacacttact tgtcaacttt 960
ctagaatcaa atctagtagc tgacagtacc aggatcaggg gtgccaaccc taagcacccc 1020
cagaaagctg actggccctg tggttcccac tccagacatg atgtcagctg tgaaatcgac 1080
gtcgctggac cataattagg cttctgttct tcaggagaca tttgttcaaa gtcatttggg 1140
caaccatatt ctgaaaacag cccagccagg gtgatggatc actttgcaaa gatcctcaat 1200
gagctatttt caagtgatga caaagtgtga agttaaccgc tcatttgaga actttctttt 1260
tcatccaaag taaattcaaa tatgattaga aatctgacct tttattactg gaattctctt 1320
gactaaaagt aaaattgaat tttaattcct aaatctccat gtgtatacag tactgtggga 1380
acatcacaga ttttggctcc atgccctaaa gagaaattgg ctttcagatt atttggatta 1440
aaaacaaaga ctttcttaag agatgtaaaa ttttcatgat gttttctttt ttgctaaaac 1500
taaagaatta ttcttttaca tttcagtgtt cctggaccac gagaacgcca acaagatcct 1560
gaaccggccc aagcggtaca acagcggcaa gctggaggag ttcgtgcagg gcaacctgga 1620
gcgggagtgc atggaggaga agtgcagctt cgaggaggcc cgggaggtgt tcgagaacac 1680
cgagcggacc accgagttct ggaagcagta cgtggacggc gaccagtgcg agagcaaccc 1740
ctgcctgaac ggcggcagct gcaaggacga catcaacagc tacgagtgct ggtgcccctt 1800
cggcttcgag ggcaagaact gcgagctgga cgtgacctgc aacatcaaga acggccggtg 1860
cgagcagttc tgcaagaaca gcgccgacaa caaggtggtg tgcagctgca ccgagggcta 1920
ccggctggcc gagaaccaga agagctgcga gcccgccgtg cccttcccct gcggccgggt 1980
gagcgtgagc cagaccagca agctgacccg ggccgagacc gtgttccccg acgtggacta 2040
cgtgaacagc accgaggccg agaccatcct ggacaacatc acccagagca cccagagctt 2100
caacgacttc acccgggtgg tgggcggcga ggacgccaag cccggccagt tcccctggca 2160
ggtggtgctg aacggcaagg tggacgcctt ctgcggcggc agcatcgtga acgagaagtg 2220
gatcgtgacc gccgcccact gcgtggagac cggcgtgaag atcaccgtgg tggccggcga 2280
gcacaacatc gaggagaccg agcacaccga gcagaagcgg aacgtgatcc ggatcatccc 2340
ccaccacaac tacaacgccg ccatcaacaa gtacaaccac gacatcgccc tgctggagct 2400
ggacgagccc ctggtgctga acagctacgt gacccccatc tgcatcgccg acaaggagta 2460
caccaacatc ttcctgaagt tcggcagcgg ctacgtgagc ggctggggcc gggtgttcca 2520
caagggccgg agcgccctgg tgctgcagta cctgcgggtg cccctggtgg accgggccac 2580
ctgcctgctg agcaccaagt tcaccatcta caacaacatg ttctgcgccg gcttccacga 2640
gggcggccgg gacagctgcc agggcgacag cggcggcccc cacgtgaccg aggtggaggg 2700
caccagcttc ctgaccggca tcatcagctg gggcgaggag tgcgccatga agggcaagta 2760
cggcatctac accaaggtga gccggtacgt gaactggatc aaggagaaga ccaagctgac 2820
c                                                                 2821

<210> 545
<211> 2821
<212> DNA
<213> Artificial Sequence

<220> 
<223> mouse optimized hFIXss-Pro-mini Intron-Pro-human
      wild type FIX optimized 0.5

<400> 545
atgcagcgcg tgaacatgat tatggccgag agccctggcc tgatcaccat ctgcctgctg 60
ggctacctgc tgagcgccga gtgtacaggt ttgtttcctt ttttaaaata cattgagtat 120
gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat 180
gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactggttc 240
tttgttagct aggttttctt cttcttcatt tttaaaacta aatagatcga caatgcttat 300
gatgcattta tgtttaataa acactgttca gttcatgatt tggtcatgta attcctgtta 360
gaaaacattc atctccttgg tttaaaaaaa ttaaaagtgg gaaaacaaag aaatagcaga 420
atatagtgaa aaaaaataac cacattattt ttgtttggac ttaccacttt gaaatcaaaa 480
tgggaaacaa aagcacaaac aatggcctta tttacacaaa aagtctgatt ttaagatata 540
tgacatttca aggtttcaga agtatgtaat gaggtgtgtc tctaattttt taaattatat 600
atcttcaatt taaagtttta gttaaaacat aaagattaac ctttcattag caagctgtta 660
gttatcacca aagcttttca tggattagga aaaaatcatt ttgtctctat gtcaaacatc 720
ttggagttga tatttgggga aacacaatac tcagttgagt tccctagggg agaaaagcaa 780
gcttaagaat tgacataaag agtaggaagt tagctaatgc aacatatatc actttgtttt 840
ttcacaacta cagtgacttt atgtatttcc cagaggaagg catacaggga agaaattatc 900
ccatttggac aaacagcatg ttctcacagg aagcatttat cacacttact tgtcaacttt 960
ctagaatcaa atctagtagc tgacagtacc aggatcaggg gtgccaaccc taagcacccc 1020
cagaaagctg actggccctg tggttcccac tccagacatg atgtcagctg tgaaatcgac 1080
gtcgctggac cataattagg cttctgttct tcaggagaca tttgttcaaa gtcatttggg 1140
caaccatatt ctgaaaacag cccagccagg gtgatggatc actttgcaaa gatcctcaat 1200
gagctatttt caagtgatga caaagtgtga agttaaccgc tcatttgaga actttctttt 1260
tcatccaaag taaattcaaa tatgattaga aatctgacct tttattactg gaattctctt 1320
gactaaaagt aaaattgaat tttaattcct aaatctccat gtgtatacag tactgtggga 1380
acatcacaga ttttggctcc atgccctaaa gagaaattgg ctttcagatt atttggatta 1440
aaaacaaaga ctttcttaag agatgtaaaa ttttcatgat gttttctttt ttgctaaaac 1500
taaagaatta ttcttttaca tttcagtgtt tctggatcat gaaaacgcca acaaaattct 1560
gaatcggcca aagaggtata attcaggcaa actggaagag tttgtgcagg ggaacctgga 1620
gagagaatgt atggaagaaa agtgtagttt tgaagaagca cgagaagtgt ttgaaaacac 1680
tgaaagaaca actgaatttt ggaagcagta tgtggatgga gatcagtgtg agtccaatcc 1740
atgtctgaat ggcggcagtt gcaaggatga cattaattcc tatgaatgtt ggtgtccctt 1800
tggatttgaa ggaaagaact gtgaactgga tgtgacatgt aacattaaga atggcagatg 1860
cgagcagttt tgtaaaaata gtgctgataa caaggtggtg tgctcctgta ctgagggata 1920
tcgactggca gaaaaccaga agtcctgtga accagcagtg ccatttccat gtggaagagt 1980
gtctgtgtca cagacttcta agctgacccg ggctgagact gtgtttcctg atgtggacta 2040
tgtgaattct actgaagctg aaaccattct ggataacatc actcagagca cccagtcatt 2100
taatgacttc actcgggtgg tgggcggaga agatgccaaa ccaggccagt tcccttggca 2160
ggtggtgctg aatggcaaag tggatgcatt ctgtggaggc tctatcgtga atgaaaaatg 2220
gattgtgact gctgcccact gtgtggaaac tggcgtgaaa attacagtgg tcgcaggcga 2280
acataatatt gaggagacag aacatacaga gcagaagcga aatgtgattc gaattattcc 2340
tcaccacaac tacaatgcag ctattaataa gtacaaccat gacattgccc tgctggaact 2400
ggacgaaccc ctggtgctga acagctacgt gacacctatt tgcattgctg acaaggaata 2460
caccaacatc ttcctgaaat ttggatctgg ctatgtgagt ggctggggaa gagtcttcca 2520
caaagggaga tcagctctgg tgctgcagta cctgagagtg ccactggtgg accgagccac 2580
atgtctgcga tctacaaagt tcaccatcta taacaacatg ttctgtgctg gcttccatga 2640
aggaggcaga gattcatgtc agggagatag tgggggaccc catgtgactg aagtggaagg 2700
gaccagtttc ctgactggaa ttattagctg gggcgaagag tgtgcaatga aaggcaaata 2760
tggaatctat accaaggtgt cccggtatgt caactggatt aaggaaaaaa caaagctgac 2820
t                                                                 2821

<210> 546
<211> 2821
<212> DNA
<213> Artificial Sequence

<220> 
<223> mouse optimized hFIXss-Pro-mini Intron-Pro-human
      wild type FIX optimized 0.8

<400> 546
atgcagcgcg tgaacatgat tatggccgag agccctggcc tgatcaccat ctgcctgctg 60
ggctacctgc tgagcgccga gtgtacaggt ttgtttcctt ttttaaaata cattgagtat 120
gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat 180
gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactggttc 240
tttgttagct aggttttctt cttcttcatt tttaaaacta aatagatcga caatgcttat 300
gatgcattta tgtttaataa acactgttca gttcatgatt tggtcatgta attcctgtta 360
gaaaacattc atctccttgg tttaaaaaaa ttaaaagtgg gaaaacaaag aaatagcaga 420
atatagtgaa aaaaaataac cacattattt ttgtttggac ttaccacttt gaaatcaaaa 480
tgggaaacaa aagcacaaac aatggcctta tttacacaaa aagtctgatt ttaagatata 540
tgacatttca aggtttcaga agtatgtaat gaggtgtgtc tctaattttt taaattatat 600
atcttcaatt taaagtttta gttaaaacat aaagattaac ctttcattag caagctgtta 660
gttatcacca aagcttttca tggattagga aaaaatcatt ttgtctctat gtcaaacatc 720
ttggagttga tatttgggga aacacaatac tcagttgagt tccctagggg agaaaagcaa 780
gcttaagaat tgacataaag agtaggaagt tagctaatgc aacatatatc actttgtttt 840
ttcacaacta cagtgacttt atgtatttcc cagaggaagg catacaggga agaaattatc 900
ccatttggac aaacagcatg ttctcacagg aagcatttat cacacttact tgtcaacttt 960
ctagaatcaa atctagtagc tgacagtacc aggatcaggg gtgccaaccc taagcacccc 1020
cagaaagctg actggccctg tggttcccac tccagacatg atgtcagctg tgaaatcgac 1080
gtcgctggac cataattagg cttctgttct tcaggagaca tttgttcaaa gtcatttggg 1140
caaccatatt ctgaaaacag cccagccagg gtgatggatc actttgcaaa gatcctcaat 1200
gagctatttt caagtgatga caaagtgtga agttaaccgc tcatttgaga actttctttt 1260
tcatccaaag taaattcaaa tatgattaga aatctgacct tttattactg gaattctctt 1320
gactaaaagt aaaattgaat tttaattcct aaatctccat gtgtatacag tactgtggga 1380
acatcacaga ttttggctcc atgccctaaa gagaaattgg ctttcagatt atttggatta 1440
aaaacaaaga ctttcttaag agatgtaaaa ttttcatgat gttttctttt ttgctaaaac 1500
taaagaatta ttcttttaca tttcagtgtt tctggatcac gagaacgcca acaagatcct 1560
gaatcggcca aagaggtaca atagcggcaa gctggaggag tttgtgcagg gcaacctgga 1620
gagagagtgt atggaggaga agtgtagctt tgaggaggcc cgggaggtgt ttgagaacac 1680
cgagagaacc accgagtttt ggaagcagta cgtggatggc gatcagtgtg agtccaatcc 1740
atgtctgaat ggcggcagct gcaaggatga catcaattcc tacgagtgtt ggtgtccctt 1800
tggctttgag ggcaagaact gtgagctgga tgtgacctgt aacatcaaga atggcagatg 1860
cgagcagttt tgtaagaata gcgccgataa caaggtggtg tgctcctgta ccgagggcta 1920
ccggctggcc gagaaccaga agtcctgtga gccagccgtg ccatttccat gtggcagagt 1980
gagcgtgagc cagaccagca agctgacccg ggccgagacc gtgtttcctg atgtggacta 2040
cgtgaatagc accgaggccg agaccatcct ggataacatc acccagagca cccagagctt 2100
taatgacttc acccgggtgg tgggcggcga ggatgccaag ccaggccagt tcccttggca 2160
ggtggtgctg aatggcaagg tggatgcctt ctgtggcggc agcatcgtga atgagaagtg 2220
gatcgtgacc gccgcccact gtgtggagac cggcgtgaag atcaccgtgg tggccggcga 2280
gcacaatatc gaggagaccg agcacaccga gcagaagcgg aatgtgatcc ggatcatccc 2340
tcaccacaac tacaatgccg ccatcaataa gtacaaccac gacatcgccc tgctggagct 2400
ggacgagccc ctggtgctga acagctacgt gacccctatc tgcatcgccg acaaggagta 2460
caccaacatc ttcctgaagt ttggcagcgg ctacgtgagc ggctggggca gagtgttcca 2520
caagggcaga agcgccctgg tgctgcagta cctgagagtg ccactggtgg accgggccac 2580
ctgtctgcgg agcaccaagt tcaccatcta caacaacatg ttctgtgccg gcttccacga 2640
gggcggcaga gatagctgtc agggcgatag cggcggcccc cacgtgaccg aggtggaggg 2700
caccagcttc ctgaccggca tcatcagctg gggcgaggag tgtgccatga agggcaagta 2760
cggcatctac accaaggtgt cccggtacgt gaactggatc aaggagaaga ccaagctgac 2820
c                                                                 2821

<210> 547
<211> 2821
<212> DNA
<213> Artificial Sequence

<220> 
<223> mouse optimized hFIXss-Pro-mini Intron-Pro-human
      wild type FIX optimized 1.0

<400> 547
atgcagcgcg tgaacatgat tatggccgag agccctggcc tgatcaccat ctgcctgctg 60
ggctacctgc tgagcgccga gtgtacaggt ttgtttcctt ttttaaaata cattgagtat 120
gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat 180
gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactggttc 240
tttgttagct aggttttctt cttcttcatt tttaaaacta aatagatcga caatgcttat 300
gatgcattta tgtttaataa acactgttca gttcatgatt tggtcatgta attcctgtta 360
gaaaacattc atctccttgg tttaaaaaaa ttaaaagtgg gaaaacaaag aaatagcaga 420
atatagtgaa aaaaaataac cacattattt ttgtttggac ttaccacttt gaaatcaaaa 480
tgggaaacaa aagcacaaac aatggcctta tttacacaaa aagtctgatt ttaagatata 540
tgacatttca aggtttcaga agtatgtaat gaggtgtgtc tctaattttt taaattatat 600
atcttcaatt taaagtttta gttaaaacat aaagattaac ctttcattag caagctgtta 660
gttatcacca aagcttttca tggattagga aaaaatcatt ttgtctctat gtcaaacatc 720
ttggagttga tatttgggga aacacaatac tcagttgagt tccctagggg agaaaagcaa 780
gcttaagaat tgacataaag agtaggaagt tagctaatgc aacatatatc actttgtttt 840
ttcacaacta cagtgacttt atgtatttcc cagaggaagg catacaggga agaaattatc 900
ccatttggac aaacagcatg ttctcacagg aagcatttat cacacttact tgtcaacttt 960
ctagaatcaa atctagtagc tgacagtacc aggatcaggg gtgccaaccc taagcacccc 1020
cagaaagctg actggccctg tggttcccac tccagacatg atgtcagctg tgaaatcgac 1080
gtcgctggac cataattagg cttctgttct tcaggagaca tttgttcaaa gtcatttggg 1140
caaccatatt ctgaaaacag cccagccagg gtgatggatc actttgcaaa gatcctcaat 1200
gagctatttt caagtgatga caaagtgtga agttaaccgc tcatttgaga actttctttt 1260
tcatccaaag taaattcaaa tatgattaga aatctgacct tttattactg gaattctctt 1320
gactaaaagt aaaattgaat tttaattcct aaatctccat gtgtatacag tactgtggga 1380
acatcacaga ttttggctcc atgccctaaa gagaaattgg ctttcagatt atttggatta 1440
aaaacaaaga ctttcttaag agatgtaaaa ttttcatgat gttttctttt ttgctaaaac 1500
taaagaatta ttcttttaca tttcagtgtt cctggaccac gagaacgcca acaagatcct 1560
gaaccggccc aagcggtaca acagcggcaa gctggaggag ttcgtgcagg gcaacctgga 1620
gcgggagtgc atggaggaga agtgcagctt cgaggaggcc cgggaggtgt tcgagaacac 1680
cgagcggacc accgagttct ggaagcagta cgtggacggc gaccagtgcg agagcaaccc 1740
ctgcctgaac ggcggcagct gcaaggacga catcaacagc tacgagtgct ggtgcccctt 1800
cggcttcgag ggcaagaact gcgagctgga cgtgacctgc aacatcaaga acggccggtg 1860
cgagcagttc tgcaagaaca gcgccgacaa caaggtggtg tgcagctgca ccgagggcta 1920
ccggctggcc gagaaccaga agagctgcga gcccgccgtg cccttcccct gcggccgggt 1980
gagcgtgagc cagaccagca agctgacccg ggccgagacc gtgttccccg acgtggacta 2040
cgtgaacagc accgaggccg agaccatcct ggacaacatc acccagagca cccagagctt 2100
caacgacttc acccgggtgg tgggcggcga ggacgccaag cccggccagt tcccctggca 2160
ggtggtgctg aacggcaagg tggacgcctt ctgcggcggc agcatcgtga acgagaagtg 2220
gatcgtgacc gccgcccact gcgtggagac cggcgtgaag atcaccgtgg tggccggcga 2280
gcacaacatc gaggagaccg agcacaccga gcagaagcgg aacgtgatcc ggatcatccc 2340
ccaccacaac tacaacgccg ccatcaacaa gtacaaccac gacatcgccc tgctggagct 2400
ggacgagccc ctggtgctga acagctacgt gacccccatc tgcatcgccg acaaggagta 2460
caccaacatc ttcctgaagt tcggcagcgg ctacgtgagc ggctggggcc gggtgttcca 2520
caagggccgg agcgccctgg tgctgcagta cctgcgggtg cccctggtgg accgggccac 2580
ctgcctgcgg agcaccaagt tcaccatcta caacaacatg ttctgcgccg gcttccacga 2640
gggcggccgg gacagctgcc agggcgacag cggcggcccc cacgtgaccg aggtggaggg 2700
caccagcttc ctgaccggca tcatcagctg gggcgaggag tgcgccatga agggcaagta 2760
cggcatctac accaaggtga gccggtacgt gaactggatc aaggagaaga ccaagctgac 2820
c                                                                 2821

<210> 548
<211> 2821
<212> DNA
<213> Artificial Sequence

<220> 
<223> mouse optimized hFIXss-Pro-mini Intron-Pro-human
      FIX R318Y/R338E/T343R optimized 0.5

<400> 548
atgcagcgcg tgaacatgat tatggccgag agccctggcc tgatcaccat ctgcctgctg 60
ggctacctgc tgagcgccga gtgtacaggt ttgtttcctt ttttaaaata cattgagtat 120
gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat 180
gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactggttc 240
tttgttagct aggttttctt cttcttcatt tttaaaacta aatagatcga caatgcttat 300
gatgcattta tgtttaataa acactgttca gttcatgatt tggtcatgta attcctgtta 360
gaaaacattc atctccttgg tttaaaaaaa ttaaaagtgg gaaaacaaag aaatagcaga 420
atatagtgaa aaaaaataac cacattattt ttgtttggac ttaccacttt gaaatcaaaa 480
tgggaaacaa aagcacaaac aatggcctta tttacacaaa aagtctgatt ttaagatata 540
tgacatttca aggtttcaga agtatgtaat gaggtgtgtc tctaattttt taaattatat 600
atcttcaatt taaagtttta gttaaaacat aaagattaac ctttcattag caagctgtta 660
gttatcacca aagcttttca tggattagga aaaaatcatt ttgtctctat gtcaaacatc 720
ttggagttga tatttgggga aacacaatac tcagttgagt tccctagggg agaaaagcaa 780
gcttaagaat tgacataaag agtaggaagt tagctaatgc aacatatatc actttgtttt 840
ttcacaacta cagtgacttt atgtatttcc cagaggaagg catacaggga agaaattatc 900
ccatttggac aaacagcatg ttctcacagg aagcatttat cacacttact tgtcaacttt 960
ctagaatcaa atctagtagc tgacagtacc aggatcaggg gtgccaaccc taagcacccc 1020
cagaaagctg actggccctg tggttcccac tccagacatg atgtcagctg tgaaatcgac 1080
gtcgctggac cataattagg cttctgttct tcaggagaca tttgttcaaa gtcatttggg 1140
caaccatatt ctgaaaacag cccagccagg gtgatggatc actttgcaaa gatcctcaat 1200
gagctatttt caagtgatga caaagtgtga agttaaccgc tcatttgaga actttctttt 1260
tcatccaaag taaattcaaa tatgattaga aatctgacct tttattactg gaattctctt 1320
gactaaaagt aaaattgaat tttaattcct aaatctccat gtgtatacag tactgtggga 1380
acatcacaga ttttggctcc atgccctaaa gagaaattgg ctttcagatt atttggatta 1440
aaaacaaaga ctttcttaag agatgtaaaa ttttcatgat gttttctttt ttgctaaaac 1500
taaagaatta ttcttttaca tttcagtgtt tctggatcat gaaaacgcca acaaaattct 1560
gaatcggcca aagaggtata attcaggcaa actggaagag tttgtgcagg ggaacctgga 1620
gagagaatgt atggaagaaa agtgtagttt tgaagaagca cgagaagtgt ttgaaaacac 1680
tgaaagaaca actgaatttt ggaagcagta tgtggatgga gatcagtgtg agtccaatcc 1740
atgtctgaat ggcggcagtt gcaaggatga cattaattcc tatgaatgtt ggtgtccctt 1800
tggatttgaa ggaaagaact gtgaactgga tgtgacatgt aacattaaga atggcagatg 1860
cgagcagttt tgtaaaaata gtgctgataa caaggtggtg tgctcctgta ctgagggata 1920
tcgactggca gaaaaccaga agtcctgtga accagcagtg ccatttccat gtggaagagt 1980
gtctgtgtca cagacttcta agctgacccg ggctgagact gtgtttcctg atgtggacta 2040
tgtgaattct actgaagctg aaaccattct ggataacatc actcagagca cccagtcatt 2100
taatgacttc actcgggtgg tgggcggaga agatgccaaa ccaggccagt tcccttggca 2160
ggtggtgctg aatggcaaag tggatgcatt ctgtggaggc tctatcgtga atgaaaaatg 2220
gattgtgact gctgcccact gtgtggaaac tggcgtgaaa attacagtgg tcgcaggcga 2280
acataatatt gaggagacag aacatacaga gcagaagcga aatgtgattc gaattattcc 2340
tcaccacaac tacaatgcag ctattaataa gtacaaccat gacattgccc tgctggaact 2400
ggacgaaccc ctggtgctga acagctacgt gacacctatt tgcattgctg acaaggaata 2460
caccaacatc ttcctgaaat ttggatctgg ctatgtgagt ggctggggaa gagtcttcca 2520
caaagggtac tcagctctgg tgctgcagta cctgagagtg ccactggtgg accgagccac 2580
atgtctggag tctacaaagt tccggatcta taacaacatg ttctgtgctg gcttccatga 2640
aggaggcaga gattcatgtc agggagatag tgggggaccc catgtgactg aagtggaagg 2700
gaccagtttc ctgactggaa ttattagctg gggcgaagag tgtgcaatga aaggcaaata 2760
tggaatctat accaaggtgt cccggtatgt caactggatt aaggaaaaaa caaagctgac 2820
t                                                                 2821

<210> 549
<211> 2821
<212> DNA
<213> Artificial Sequence

<220> 
<223> mouse optimized hFIXss-Pro-mini Intron-Pro-human
      FIX R318Y/R338E/T343R optimized 0.8

<400> 549
atgcagcgcg tgaacatgat tatggccgag agccctggcc tgatcaccat ctgcctgctg 60
ggctacctgc tgagcgccga gtgtacaggt ttgtttcctt ttttaaaata cattgagtat 120
gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat 180
gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactggttc 240
tttgttagct aggttttctt cttcttcatt tttaaaacta aatagatcga caatgcttat 300
gatgcattta tgtttaataa acactgttca gttcatgatt tggtcatgta attcctgtta 360
gaaaacattc atctccttgg tttaaaaaaa ttaaaagtgg gaaaacaaag aaatagcaga 420
atatagtgaa aaaaaataac cacattattt ttgtttggac ttaccacttt gaaatcaaaa 480
tgggaaacaa aagcacaaac aatggcctta tttacacaaa aagtctgatt ttaagatata 540
tgacatttca aggtttcaga agtatgtaat gaggtgtgtc tctaattttt taaattatat 600
atcttcaatt taaagtttta gttaaaacat aaagattaac ctttcattag caagctgtta 660
gttatcacca aagcttttca tggattagga aaaaatcatt ttgtctctat gtcaaacatc 720
ttggagttga tatttgggga aacacaatac tcagttgagt tccctagggg agaaaagcaa 780
gcttaagaat tgacataaag agtaggaagt tagctaatgc aacatatatc actttgtttt 840
ttcacaacta cagtgacttt atgtatttcc cagaggaagg catacaggga agaaattatc 900
ccatttggac aaacagcatg ttctcacagg aagcatttat cacacttact tgtcaacttt 960
ctagaatcaa atctagtagc tgacagtacc aggatcaggg gtgccaaccc taagcacccc 1020
cagaaagctg actggccctg tggttcccac tccagacatg atgtcagctg tgaaatcgac 1080
gtcgctggac cataattagg cttctgttct tcaggagaca tttgttcaaa gtcatttggg 1140
caaccatatt ctgaaaacag cccagccagg gtgatggatc actttgcaaa gatcctcaat 1200
gagctatttt caagtgatga caaagtgtga agttaaccgc tcatttgaga actttctttt 1260
tcatccaaag taaattcaaa tatgattaga aatctgacct tttattactg gaattctctt 1320
gactaaaagt aaaattgaat tttaattcct aaatctccat gtgtatacag tactgtggga 1380
acatcacaga ttttggctcc atgccctaaa gagaaattgg ctttcagatt atttggatta 1440
aaaacaaaga ctttcttaag agatgtaaaa ttttcatgat gttttctttt ttgctaaaac 1500
taaagaatta ttcttttaca tttcagtgtt tctggatcac gagaacgcca acaagatcct 1560
gaatcggcca aagaggtaca atagcggcaa gctggaggag tttgtgcagg gcaacctgga 1620
gagagagtgt atggaggaga agtgtagctt tgaggaggcc cgggaggtgt ttgagaacac 1680
cgagagaacc accgagtttt ggaagcagta cgtggatggc gatcagtgtg agtccaatcc 1740
atgtctgaat ggcggcagct gcaaggatga catcaattcc tacgagtgtt ggtgtccctt 1800
tggctttgag ggcaagaact gtgagctgga tgtgacctgt aacatcaaga atggcagatg 1860
cgagcagttt tgtaagaata gcgccgataa caaggtggtg tgctcctgta ccgagggcta 1920
ccggctggcc gagaaccaga agtcctgtga gccagccgtg ccatttccat gtggcagagt 1980
gagcgtgagc cagaccagca agctgacccg ggccgagacc gtgtttcctg atgtggacta 2040
cgtgaatagc accgaggccg agaccatcct ggataacatc acccagagca cccagagctt 2100
taatgacttc acccgggtgg tgggcggcga ggatgccaag ccaggccagt tcccttggca 2160
ggtggtgctg aatggcaagg tggatgcctt ctgtggcggc agcatcgtga atgagaagtg 2220
gatcgtgacc gccgcccact gtgtggagac cggcgtgaag atcaccgtgg tggccggcga 2280
gcacaatatc gaggagaccg agcacaccga gcagaagcgg aatgtgatcc ggatcatccc 2340
tcaccacaac tacaatgccg ccatcaataa gtacaaccac gacatcgccc tgctggagct 2400
ggacgagccc ctggtgctga acagctacgt gacccctatc tgcatcgccg acaaggagta 2460
caccaacatc ttcctgaagt ttggcagcgg ctacgtgagc ggctggggca gagtgttcca 2520
caagggctac agcgccctgg tgctgcagta cctgagagtg ccactggtgg accgggccac 2580
ctgtctggag agcaccaagt tccggatcta caacaacatg ttctgtgccg gcttccacga 2640
gggcggcaga gatagctgtc agggcgatag cggcggcccc cacgtgaccg aggtggaggg 2700
caccagcttc ctgaccggca tcatcagctg gggcgaggag tgtgccatga agggcaagta 2760
cggcatctac accaaggtgt cccggtacgt gaactggatc aaggagaaga ccaagctgac 2820
c                                                                 2821

<210> 550
<211> 2821
<212> DNA
<213> Artificial Sequence

<220> 
<223> mouse optimized hFIXss-Pro-mini Intron-Pro-human
      FIX R318Y/R338E/T343R optimized 1.0

<400> 550
atgcagcgcg tgaacatgat tatggccgag agccctggcc tgatcaccat ctgcctgctg 60
ggctacctgc tgagcgccga gtgtacaggt ttgtttcctt ttttaaaata cattgagtat 120
gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat 180
gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactggttc 240
tttgttagct aggttttctt cttcttcatt tttaaaacta aatagatcga caatgcttat 300
gatgcattta tgtttaataa acactgttca gttcatgatt tggtcatgta attcctgtta 360
gaaaacattc atctccttgg tttaaaaaaa ttaaaagtgg gaaaacaaag aaatagcaga 420
atatagtgaa aaaaaataac cacattattt ttgtttggac ttaccacttt gaaatcaaaa 480
tgggaaacaa aagcacaaac aatggcctta tttacacaaa aagtctgatt ttaagatata 540
tgacatttca aggtttcaga agtatgtaat gaggtgtgtc tctaattttt taaattatat 600
atcttcaatt taaagtttta gttaaaacat aaagattaac ctttcattag caagctgtta 660
gttatcacca aagcttttca tggattagga aaaaatcatt ttgtctctat gtcaaacatc 720
ttggagttga tatttgggga aacacaatac tcagttgagt tccctagggg agaaaagcaa 780
gcttaagaat tgacataaag agtaggaagt tagctaatgc aacatatatc actttgtttt 840
ttcacaacta cagtgacttt atgtatttcc cagaggaagg catacaggga agaaattatc 900
ccatttggac aaacagcatg ttctcacagg aagcatttat cacacttact tgtcaacttt 960
ctagaatcaa atctagtagc tgacagtacc aggatcaggg gtgccaaccc taagcacccc 1020
cagaaagctg actggccctg tggttcccac tccagacatg atgtcagctg tgaaatcgac 1080
gtcgctggac cataattagg cttctgttct tcaggagaca tttgttcaaa gtcatttggg 1140
caaccatatt ctgaaaacag cccagccagg gtgatggatc actttgcaaa gatcctcaat 1200
gagctatttt caagtgatga caaagtgtga agttaaccgc tcatttgaga actttctttt 1260
tcatccaaag taaattcaaa tatgattaga aatctgacct tttattactg gaattctctt 1320
gactaaaagt aaaattgaat tttaattcct aaatctccat gtgtatacag tactgtggga 1380
acatcacaga ttttggctcc atgccctaaa gagaaattgg ctttcagatt atttggatta 1440
aaaacaaaga ctttcttaag agatgtaaaa ttttcatgat gttttctttt ttgctaaaac 1500
taaagaatta ttcttttaca tttcagtgtt cctggaccac gagaacgcca acaagatcct 1560
gaaccggccc aagcggtaca acagcggcaa gctggaggag ttcgtgcagg gcaacctgga 1620
gcgggagtgc atggaggaga agtgcagctt cgaggaggcc cgggaggtgt tcgagaacac 1680
cgagcggacc accgagttct ggaagcagta cgtggacggc gaccagtgcg agagcaaccc 1740
ctgcctgaac ggcggcagct gcaaggacga catcaacagc tacgagtgct ggtgcccctt 1800
cggcttcgag ggcaagaact gcgagctgga cgtgacctgc aacatcaaga acggccggtg 1860
cgagcagttc tgcaagaaca gcgccgacaa caaggtggtg tgcagctgca ccgagggcta 1920
ccggctggcc gagaaccaga agagctgcga gcccgccgtg cccttcccct gcggccgggt 1980
gagcgtgagc cagaccagca agctgacccg ggccgagacc gtgttccccg acgtggacta 2040
cgtgaacagc accgaggccg agaccatcct ggacaacatc acccagagca cccagagctt 2100
caacgacttc acccgggtgg tgggcggcga ggacgccaag cccggccagt tcccctggca 2160
ggtggtgctg aacggcaagg tggacgcctt ctgcggcggc agcatcgtga acgagaagtg 2220
gatcgtgacc gccgcccact gcgtggagac cggcgtgaag atcaccgtgg tggccggcga 2280
gcacaacatc gaggagaccg agcacaccga gcagaagcgg aacgtgatcc ggatcatccc 2340
ccaccacaac tacaacgccg ccatcaacaa gtacaaccac gacatcgccc tgctggagct 2400
ggacgagccc ctggtgctga acagctacgt gacccccatc tgcatcgccg acaaggagta 2460
caccaacatc ttcctgaagt tcggcagcgg ctacgtgagc ggctggggcc gggtgttcca 2520
caagggctac agcgccctgg tgctgcagta cctgcgggtg cccctggtgg accgggccac 2580
ctgcctggag agcaccaagt tccggatcta caacaacatg ttctgcgccg gcttccacga 2640
gggcggccgg gacagctgcc agggcgacag cggcggcccc cacgtgaccg aggtggaggg 2700
caccagcttc ctgaccggca tcatcagctg gggcgaggag tgcgccatga agggcaagta 2760
cggcatctac accaaggtga gccggtacgt gaactggatc aaggagaaga ccaagctgac 2820
c                                                                 2821

<210> 551
<211> 2821
<212> DNA
<213> Artificial Sequence

<220> 
<223> mouse optimized hFIXss-Pro-mini Intron-Pro-human
      FIX R338L optimized 0.5

<400> 551
atgcagcgcg tgaacatgat tatggccgag agccctggcc tgatcaccat ctgcctgctg 60
ggctacctgc tgagcgccga gtgtacaggt ttgtttcctt ttttaaaata cattgagtat 120
gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat 180
gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactggttc 240
tttgttagct aggttttctt cttcttcatt tttaaaacta aatagatcga caatgcttat 300
gatgcattta tgtttaataa acactgttca gttcatgatt tggtcatgta attcctgtta 360
gaaaacattc atctccttgg tttaaaaaaa ttaaaagtgg gaaaacaaag aaatagcaga 420
atatagtgaa aaaaaataac cacattattt ttgtttggac ttaccacttt gaaatcaaaa 480
tgggaaacaa aagcacaaac aatggcctta tttacacaaa aagtctgatt ttaagatata 540
tgacatttca aggtttcaga agtatgtaat gaggtgtgtc tctaattttt taaattatat 600
atcttcaatt taaagtttta gttaaaacat aaagattaac ctttcattag caagctgtta 660
gttatcacca aagcttttca tggattagga aaaaatcatt ttgtctctat gtcaaacatc 720
ttggagttga tatttgggga aacacaatac tcagttgagt tccctagggg agaaaagcaa 780
gcttaagaat tgacataaag agtaggaagt tagctaatgc aacatatatc actttgtttt 840
ttcacaacta cagtgacttt atgtatttcc cagaggaagg catacaggga agaaattatc 900
ccatttggac aaacagcatg ttctcacagg aagcatttat cacacttact tgtcaacttt 960
ctagaatcaa atctagtagc tgacagtacc aggatcaggg gtgccaaccc taagcacccc 1020
cagaaagctg actggccctg tggttcccac tccagacatg atgtcagctg tgaaatcgac 1080
gtcgctggac cataattagg cttctgttct tcaggagaca tttgttcaaa gtcatttggg 1140
caaccatatt ctgaaaacag cccagccagg gtgatggatc actttgcaaa gatcctcaat 1200
gagctatttt caagtgatga caaagtgtga agttaaccgc tcatttgaga actttctttt 1260
tcatccaaag taaattcaaa tatgattaga aatctgacct tttattactg gaattctctt 1320
gactaaaagt aaaattgaat tttaattcct aaatctccat gtgtatacag tactgtggga 1380
acatcacaga ttttggctcc atgccctaaa gagaaattgg ctttcagatt atttggatta 1440
aaaacaaaga ctttcttaag agatgtaaaa ttttcatgat gttttctttt ttgctaaaac 1500
taaagaatta ttcttttaca tttcagtgtt tctggatcat gaaaacgcca acaaaattct 1560
gaatcggcca aagaggtata attcaggcaa actggaagag tttgtgcagg ggaacctgga 1620
gagagaatgt atggaagaaa agtgtagttt tgaagaagca cgagaagtgt ttgaaaacac 1680
tgaaagaaca actgaatttt ggaagcagta tgtggatgga gatcagtgtg agtccaatcc 1740
atgtctgaat ggcggcagtt gcaaggatga cattaattcc tatgaatgtt ggtgtccctt 1800
tggatttgaa ggaaagaact gtgaactgga tgtgacatgt aacattaaga atggcagatg 1860
cgagcagttt tgtaaaaata gtgctgataa caaggtggtg tgctcctgta ctgagggata 1920
tcgactggca gaaaaccaga agtcctgtga accagcagtg ccatttccat gtggaagagt 1980
gtctgtgtca cagacttcta agctgacccg ggctgagact gtgtttcctg atgtggacta 2040
tgtgaattct actgaagctg aaaccattct ggataacatc actcagagca cccagtcatt 2100
taatgacttc actcgggtgg tgggcggaga agatgccaaa ccaggccagt tcccttggca 2160
ggtggtgctg aatggcaaag tggatgcatt ctgtggaggc tctatcgtga atgaaaaatg 2220
gattgtgact gctgcccact gtgtggaaac tggcgtgaaa attacagtgg tcgcaggcga 2280
acataatatt gaggagacag aacatacaga gcagaagcga aatgtgattc gaattattcc 2340
tcaccacaac tacaatgcag ctattaataa gtacaaccat gacattgccc tgctggaact 2400
ggacgaaccc ctggtgctga acagctacgt gacacctatt tgcattgctg acaaggaata 2460
caccaacatc ttcctgaaat ttggatctgg ctatgtgagt ggctggggaa gagtcttcca 2520
caaagggaga tcagctctgg tgctgcagta cctgagagtg ccactggtgg accgagccac 2580
atgtctgctg tctacaaagt tcaccatcta taacaacatg ttctgtgctg gcttccatga 2640
aggaggcaga gattcatgtc agggagatag tgggggaccc catgtgactg aagtggaagg 2700
gaccagtttc ctgactggaa ttattagctg gggcgaagag tgtgcaatga aaggcaaata 2760
tggaatctat accaaggtgt cccggtatgt caactggatt aaggaaaaaa caaagctgac 2820
t                                                                 2821

<210> 552
<211> 2821
<212> DNA
<213> Artificial Sequence

<220> 
<223> mouse optimized hFIXss-Pro-mini Intron-Pro-human
      FIX R338L optimized 0.8

<400> 552
atgcagcgcg tgaacatgat tatggccgag agccctggcc tgatcaccat ctgcctgctg 60
ggctacctgc tgagcgccga gtgtacaggt ttgtttcctt ttttaaaata cattgagtat 120
gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat 180
gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactggttc 240
tttgttagct aggttttctt cttcttcatt tttaaaacta aatagatcga caatgcttat 300
gatgcattta tgtttaataa acactgttca gttcatgatt tggtcatgta attcctgtta 360
gaaaacattc atctccttgg tttaaaaaaa ttaaaagtgg gaaaacaaag aaatagcaga 420
atatagtgaa aaaaaataac cacattattt ttgtttggac ttaccacttt gaaatcaaaa 480
tgggaaacaa aagcacaaac aatggcctta tttacacaaa aagtctgatt ttaagatata 540
tgacatttca aggtttcaga agtatgtaat gaggtgtgtc tctaattttt taaattatat 600
atcttcaatt taaagtttta gttaaaacat aaagattaac ctttcattag caagctgtta 660
gttatcacca aagcttttca tggattagga aaaaatcatt ttgtctctat gtcaaacatc 720
ttggagttga tatttgggga aacacaatac tcagttgagt tccctagggg agaaaagcaa 780
gcttaagaat tgacataaag agtaggaagt tagctaatgc aacatatatc actttgtttt 840
ttcacaacta cagtgacttt atgtatttcc cagaggaagg catacaggga agaaattatc 900
ccatttggac aaacagcatg ttctcacagg aagcatttat cacacttact tgtcaacttt 960
ctagaatcaa atctagtagc tgacagtacc aggatcaggg gtgccaaccc taagcacccc 1020
cagaaagctg actggccctg tggttcccac tccagacatg atgtcagctg tgaaatcgac 1080
gtcgctggac cataattagg cttctgttct tcaggagaca tttgttcaaa gtcatttggg 1140
caaccatatt ctgaaaacag cccagccagg gtgatggatc actttgcaaa gatcctcaat 1200
gagctatttt caagtgatga caaagtgtga agttaaccgc tcatttgaga actttctttt 1260
tcatccaaag taaattcaaa tatgattaga aatctgacct tttattactg gaattctctt 1320
gactaaaagt aaaattgaat tttaattcct aaatctccat gtgtatacag tactgtggga 1380
acatcacaga ttttggctcc atgccctaaa gagaaattgg ctttcagatt atttggatta 1440
aaaacaaaga ctttcttaag agatgtaaaa ttttcatgat gttttctttt ttgctaaaac 1500
taaagaatta ttcttttaca tttcagtgtt tctggatcac gagaacgcca acaagatcct 1560
gaatcggcca aagaggtaca atagcggcaa gctggaggag tttgtgcagg gcaacctgga 1620
gagagagtgt atggaggaga agtgtagctt tgaggaggcc cgggaggtgt ttgagaacac 1680
cgagagaacc accgagtttt ggaagcagta cgtggatggc gatcagtgtg agtccaatcc 1740
atgtctgaat ggcggcagct gcaaggatga catcaattcc tacgagtgtt ggtgtccctt 1800
tggctttgag ggcaagaact gtgagctgga tgtgacctgt aacatcaaga atggcagatg 1860
cgagcagttt tgtaagaata gcgccgataa caaggtggtg tgctcctgta ccgagggcta 1920
ccggctggcc gagaaccaga agtcctgtga gccagccgtg ccatttccat gtggcagagt 1980
gagcgtgagc cagaccagca agctgacccg ggccgagacc gtgtttcctg atgtggacta 2040
cgtgaatagc accgaggccg agaccatcct ggataacatc acccagagca cccagagctt 2100
taatgacttc acccgggtgg tgggcggcga ggatgccaag ccaggccagt tcccttggca 2160
ggtggtgctg aatggcaagg tggatgcctt ctgtggcggc agcatcgtga atgagaagtg 2220
gatcgtgacc gccgcccact gtgtggagac cggcgtgaag atcaccgtgg tggccggcga 2280
gcacaatatc gaggagaccg agcacaccga gcagaagcgg aatgtgatcc ggatcatccc 2340
tcaccacaac tacaatgccg ccatcaataa gtacaaccac gacatcgccc tgctggagct 2400
ggacgagccc ctggtgctga acagctacgt gacccctatc tgcatcgccg acaaggagta 2460
caccaacatc ttcctgaagt ttggcagcgg ctacgtgagc ggctggggca gagtgttcca 2520
caagggcaga agcgccctgg tgctgcagta cctgagagtg ccactggtgg accgggccac 2580
ctgtctgctg agcaccaagt tcaccatcta caacaacatg ttctgtgccg gcttccacga 2640
gggcggcaga gatagctgtc agggcgatag cggcggcccc cacgtgaccg aggtggaggg 2700
caccagcttc ctgaccggca tcatcagctg gggcgaggag tgtgccatga agggcaagta 2760
cggcatctac accaaggtgt cccggtacgt gaactggatc aaggagaaga ccaagctgac 2820
c                                                                 2821

<210> 553
<211> 2821
<212> DNA
<213> Artificial Sequence

<220> 
<223> mouse optimized hFIXss-Pro-mini Intron-Pro-human
      FIX R338L optimized 1.0

<400> 553
atgcagcgcg tgaacatgat tatggccgag agccctggcc tgatcaccat ctgcctgctg 60
ggctacctgc tgagcgccga gtgtacaggt ttgtttcctt ttttaaaata cattgagtat 120
gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat 180
gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactggttc 240
tttgttagct aggttttctt cttcttcatt tttaaaacta aatagatcga caatgcttat 300
gatgcattta tgtttaataa acactgttca gttcatgatt tggtcatgta attcctgtta 360
gaaaacattc atctccttgg tttaaaaaaa ttaaaagtgg gaaaacaaag aaatagcaga 420
atatagtgaa aaaaaataac cacattattt ttgtttggac ttaccacttt gaaatcaaaa 480
tgggaaacaa aagcacaaac aatggcctta tttacacaaa aagtctgatt ttaagatata 540
tgacatttca aggtttcaga agtatgtaat gaggtgtgtc tctaattttt taaattatat 600
atcttcaatt taaagtttta gttaaaacat aaagattaac ctttcattag caagctgtta 660
gttatcacca aagcttttca tggattagga aaaaatcatt ttgtctctat gtcaaacatc 720
ttggagttga tatttgggga aacacaatac tcagttgagt tccctagggg agaaaagcaa 780
gcttaagaat tgacataaag agtaggaagt tagctaatgc aacatatatc actttgtttt 840
ttcacaacta cagtgacttt atgtatttcc cagaggaagg catacaggga agaaattatc 900
ccatttggac aaacagcatg ttctcacagg aagcatttat cacacttact tgtcaacttt 960
ctagaatcaa atctagtagc tgacagtacc aggatcaggg gtgccaaccc taagcacccc 1020
cagaaagctg actggccctg tggttcccac tccagacatg atgtcagctg tgaaatcgac 1080
gtcgctggac cataattagg cttctgttct tcaggagaca tttgttcaaa gtcatttggg 1140
caaccatatt ctgaaaacag cccagccagg gtgatggatc actttgcaaa gatcctcaat 1200
gagctatttt caagtgatga caaagtgtga agttaaccgc tcatttgaga actttctttt 1260
tcatccaaag taaattcaaa tatgattaga aatctgacct tttattactg gaattctctt 1320
gactaaaagt aaaattgaat tttaattcct aaatctccat gtgtatacag tactgtggga 1380
acatcacaga ttttggctcc atgccctaaa gagaaattgg ctttcagatt atttggatta 1440
aaaacaaaga ctttcttaag agatgtaaaa ttttcatgat gttttctttt ttgctaaaac 1500
taaagaatta ttcttttaca tttcagtgtt cctggaccac gagaacgcca acaagatcct 1560
gaaccggccc aagcggtaca acagcggcaa gctggaggag ttcgtgcagg gcaacctgga 1620
gcgggagtgc atggaggaga agtgcagctt cgaggaggcc cgggaggtgt tcgagaacac 1680
cgagcggacc accgagttct ggaagcagta cgtggacggc gaccagtgcg agagcaaccc 1740
ctgcctgaac ggcggcagct gcaaggacga catcaacagc tacgagtgct ggtgcccctt 1800
cggcttcgag ggcaagaact gcgagctgga cgtgacctgc aacatcaaga acggccggtg 1860
cgagcagttc tgcaagaaca gcgccgacaa caaggtggtg tgcagctgca ccgagggcta 1920
ccggctggcc gagaaccaga agagctgcga gcccgccgtg cccttcccct gcggccgggt 1980
gagcgtgagc cagaccagca agctgacccg ggccgagacc gtgttccccg acgtggacta 2040
cgtgaacagc accgaggccg agaccatcct ggacaacatc acccagagca cccagagctt 2100
caacgacttc acccgggtgg tgggcggcga ggacgccaag cccggccagt tcccctggca 2160
ggtggtgctg aacggcaagg tggacgcctt ctgcggcggc agcatcgtga acgagaagtg 2220
gatcgtgacc gccgcccact gcgtggagac cggcgtgaag atcaccgtgg tggccggcga 2280
gcacaacatc gaggagaccg agcacaccga gcagaagcgg aacgtgatcc ggatcatccc 2340
ccaccacaac tacaacgccg ccatcaacaa gtacaaccac gacatcgccc tgctggagct 2400
ggacgagccc ctggtgctga acagctacgt gacccccatc tgcatcgccg acaaggagta 2460
caccaacatc ttcctgaagt tcggcagcgg ctacgtgagc ggctggggcc gggtgttcca 2520
caagggccgg agcgccctgg tgctgcagta cctgcgggtg cccctggtgg accgggccac 2580
ctgcctgctg agcaccaagt tcaccatcta caacaacatg ttctgcgccg gcttccacga 2640
gggcggccgg gacagctgcc agggcgacag cggcggcccc cacgtgaccg aggtggaggg 2700
caccagcttc ctgaccggca tcatcagctg gggcgaggag tgcgccatga agggcaagta 2760
cggcatctac accaaggtga gccggtacgt gaactggatc aaggagaaga ccaagctgac 2820
c                                                                 2821

<210> 554
<211> 252
<212> DNA
<213> Artificial Sequence

<220> 
<223> hybrid liver specific promoter (HLP)

<400> 554
tgtttgctgc ttgcaatgtt tgcccatttt agggtggaca caggacgctg tggtttctga 60
gccagggggc gactcagatc ccagccagtg gacttagccc ctgtttgctc ctccgataac 120
tggggtgacc ttggttaata ttcaccagca gcctcccccg ttgcccctct ggatccactg 180
cttaaatacg gacgaggaca gggccctgtc tcctcagctt caggcaccac cactgacctg 240
ggacagtgaa tc                                                     252

<210> 555
<211> 4761
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV vector

<400> 555
gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg 60
acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg 120
gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag 180
ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg 240
gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct 300
cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac 360
agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact 420
catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga 480
tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt 540
cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct 600
gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc 660
taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc 720
ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc 780
tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg 840
ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt 900
cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg 960
agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg 1020
gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt 1080
atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag 1140
gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt 1200
gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta 1260
ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt 1320
cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc 1380
cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca 1440
acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc 1500
cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg 1560
accatgatta cgccaagctt gcatgcctgc aggcagctgc gcgctcgctc gctcactgag 1620
gccgcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag 1680
agagggagtg gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtaaag 1740
atctgatatc atcgatcgcg atgcattaat taagcggccg aggctcagag gcacacagga 1800
gtttctgggc tcaccctgcc cccttccaac ccctcagttc ccatcctcca gcagctgttt 1860
gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc tactcatgtc cctaaaatgg 1920
gcaaacattg caagcagcaa acagcaaaca cacagccctc cctgcctgct gaccttggag 1980
ctggggcaga ggtcagagac ctctctgggc ccatgccacc tccaacatcc actcgacccc 2040
ttggaatttc ggtggagagg agcagaggtt gtcctggcgt ggtttaggta gtgtgagagg 2100
ggtacccggg gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga 2160
gggccagcta agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg 2220
gacacaggac gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg 2280
aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag 2340
ccagtggact tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca 2400
ccagcagcct cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc 2460
cctgtctcct cagcttcagg caccaccact gacctgggac agtgaatgat ccccctgatc 2520
tgcggcctcg acggtatcga taagcttgat atcgaattct agtcgtcgac cactttcaca 2580
atctgctagc aaaggttgcc acctgaaaga tggatttcca aggttaattc attggaattg 2640
aaaattaaca gccccccccc cccccccctg cagatctcga gccgaattcc tgcagcccgg 2700
gggatcagcc tcgactgtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt 2760
gccttccttg accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat 2820
tgcatcgcat tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag 2880
caagggggag gattgggaag acaatagcag gcatgctggg gatgcggtgg gctctatggc 2940
ttctgaggcg gaaagaacca gctggggctc gagatccact agactagtgt acacgcgtga 3000
tatcagatct gttacgtaga taagtagcat ggcgggttaa tcattaacta caaggaaccc 3060
ctagtgatgg agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga 3120
ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc 3180
agctgcctgc aggtcgactc tagaggatcc ccgggtaccg agctcgaatt cactggccgt 3240
cgttttacaa cgtcgtgact gggaaaaccc tggcgttacc caacttaatc gccttgcagc 3300
acatccccct ttcgccagct ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca 3360
acagttgcgc agcctgaatg gcgaatggcg cctgatgcgg tattttctcc ttacgcatct 3420
gtgcggtatt tcacaccgca tacgtcaaag caaccatagt acgcgccctg tagcggcgca 3480
ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc cagcgcttag 3540
cgcccgctcc tttcgctttc ttcccttcct ttctcgccac gttcgccggc tttccccgtc 3600
aagctctaaa tcgggggctc cctttagggt tccgatttag tgctttacgg cacctcgacc 3660
ccaaaaaact tgatttgggt gatggttcac gtagtgggcc atcgccctga tagacggttt 3720
ttcgcccttt gacgttggag tccacgttct ttaatagtgg actcttgttc caaactggaa 3780
caacactcaa ctctatctcg ggctattctt ttgatttata agggattttg ccgatttcgg 3840
tctattggtt aaaaaatgag ctgatttaac aaaaatttaa cgcgaatttt aacaaaatat 3900
taacgtttac aattttatgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa 3960
gccagccccg acacccgcca acacccgctg acgcgccctg acgggcttgt ctgctcccgg 4020
catccgctta cagacaagct gtgaccgtct ccgggagctg catgtgtcag aggttttcac 4080
cgtcatcacc gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt ttataggtta 4140
atgtcatgat aataatggtt tcttagacgt caggtggcac ttttcgggga aatgtgcgcg 4200
gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat 4260
aaccctgata aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc 4320
gtgtcgccct tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa 4380
cgctggtgaa agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac 4440
tggatctcaa cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga 4500
tgagcacttt taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag 4560
agcaactcgg tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca 4620
cagaaaagca tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca 4680
tgagtgataa cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa 4740
ccgctttttt gcacaacatg g                                           4761

<210> 556
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> FIX fwd sequencing primer

<400> 556
atctacaaca acatgttctg cg                                          22

<210> 557
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> FIX rev sequencing primer

<400> 557
ctgatgatgc cggtcagaaa                                             20

<210> 558
<211> 1299
<212> DNA
<213> Artificial Sequence

<220> 
<223> human wild type FIX propeptide-mature mouse
      optimized

<400> 558
gtgttcctgg accacgagaa cgccaacaag atcctgaaca gacccaagag atacaacagc 60
ggcaagctgg aagagttcgt gcagggcaac ctggaacgcg agtgcatgga agagaagtgc 120
agcttcgaag aggccagaga ggtgttcgag aacaccgaga gaaccaccga gttctggaag 180
cagtacgtgg acggcgacca gtgcgagagc aacccttgtc tgaacggcgg cagctgcaag 240
gacgacatca acagctacga gtgctggtgc cccttcggct tcgagggcaa gaactgcgag 300
ctggacgtga cctgcaacat caagaacggc agatgcgagc agttctgcaa gaacagcgcc 360
gacaacaagg tcgtgtgctc ctgcaccgag ggctacagac tggccgagaa ccagaagtcc 420
tgcgagcccg ctgtgccttt cccatgcgga agagtgtccg tgtcccagac cagcaagctg 480
accagagccg agacagtgtt ccccgacgtg gactacgtga acagcaccga ggccgagaca 540
atcctggaca acatcaccca gagcacccag tccttcaacg acttcaccag agtcgtgggc 600
ggcgaggatg ctaagcctgg ccagttcccg tggcaggtgg tgctgaacgg aaaggtggac 660
gccttctgcg gcggctccat cgtgaacgag aagtggatcg tgacagccgc ccactgcgtg 720
gaaaccggcg tgaagatcac agtggtggcc ggcgagcaca acatcgagga aaccgagcac 780
acagagcaga aaagaaacgt gatcaggatc atcccccacc acaactacaa cgccgccatc 840
aacaagtaca accacgatat cgccctgctg gaactggacg agcccctggt gctgaatagc 900
tacgtgaccc ccatctgtat cgccgacaaa gagtacacca acatctttct gaagttcggc 960
agcggctacg tgtccggctg gggcagagtg tttcacaagg gcagatccgc tctggtgctg 1020
cagtacctga gagtgcctct ggtggacaga gccacctgtc tgagaagcac caagttcacc 1080
atctacaaca acatgttctg cgctggcttc cacgagggcg gcagagactc ttgtcagggc 1140
gattctggcg gccctcacgt gacagaggtg gaaggcacca gctttctgac cggcatcatc 1200
agctggggcg aggaatgcgc catgaagggg aagtacggca tctacaccaa ggtgtccaga 1260
tacgtgaact ggatcaaaga aaagaccaag ctgacataa                        1299

<210> 559
<211> 1299
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX R338L propeptide-mature mouse optimized

<400> 559
gtgttcctgg accacgagaa cgccaacaag atcctgaaca gacccaagag atacaacagc 60
ggcaagctgg aagagttcgt gcagggcaac ctggaacgcg agtgcatgga agagaagtgc 120
agcttcgaag aggccagaga ggtgttcgag aacaccgaga gaaccaccga gttctggaag 180
cagtacgtgg acggcgacca gtgcgagagc aacccttgtc tgaacggcgg cagctgcaag 240
gacgacatca acagctacga gtgctggtgc cccttcggct tcgagggcaa gaactgcgag 300
ctggacgtga cctgcaacat caagaacggc agatgcgagc agttctgcaa gaacagcgcc 360
gacaacaagg tcgtgtgctc ctgcaccgag ggctacagac tggccgagaa ccagaagtcc 420
tgcgagcccg ctgtgccttt cccatgcgga agagtgtccg tgtcccagac cagcaagctg 480
accagagccg agacagtgtt ccccgacgtg gactacgtga acagcaccga ggccgagaca 540
atcctggaca acatcaccca gagcacccag tccttcaacg acttcaccag agtcgtgggc 600
ggcgaggatg ctaagcctgg ccagttcccg tggcaggtgg tgctgaacgg aaaggtggac 660
gccttctgcg gcggctccat cgtgaacgag aagtggatcg tgacagccgc ccactgcgtg 720
gaaaccggcg tgaagatcac agtggtggcc ggcgagcaca acatcgagga aaccgagcac 780
acagagcaga aaagaaacgt gatcaggatc atcccccacc acaactacaa cgccgccatc 840
aacaagtaca accacgatat cgccctgctg gaactggacg agcccctggt gctgaatagc 900
tacgtgaccc ccatctgtat cgccgacaaa gagtacacca acatctttct gaagttcggc 960
agcggctacg tgtccggctg gggcagagtg tttcacaagg gcagatccgc tctggtgctg 1020
cagtacctga gagtgcctct ggtggacaga gccacctgtc tgctgagcac caagttcacc 1080
atctacaaca acatgttctg cgctggcttc cacgagggcg gcagagactc ttgtcagggc 1140
gattctggcg gccctcacgt gacagaggtg gaaggcacca gctttctgac cggcatcatc 1200
agctggggcg aggaatgcgc catgaagggg aagtacggca tctacaccaa ggtgtccaga 1260
tacgtgaact ggatcaaaga aaagaccaag ctgacataa                        1299

<210> 560
<211> 1299
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX R318Y/R338E/T343R propeptide-mature
      mouse optimized

<400> 560
gtgttcctgg accacgagaa cgccaacaag atcctgaaca gacccaagag atacaacagc 60
ggcaagctgg aagagttcgt gcagggcaac ctggaacgcg agtgcatgga agagaagtgc 120
agcttcgaag aggccagaga ggtgttcgag aacaccgaga gaaccaccga gttctggaag 180
cagtacgtgg acggcgacca gtgcgagagc aacccttgtc tgaacggcgg cagctgcaag 240
gacgacatca acagctacga gtgctggtgc cccttcggct tcgagggcaa gaactgcgag 300
ctggacgtga cctgcaacat caagaacggc agatgcgagc agttctgcaa gaacagcgcc 360
gacaacaagg tcgtgtgctc ctgcaccgag ggctacagac tggccgagaa ccagaagtcc 420
tgcgagcccg ctgtgccttt cccatgcgga agagtgtccg tgtcccagac cagcaagctg 480
accagagccg agacagtgtt ccccgacgtg gactacgtga acagcaccga ggccgagaca 540
atcctggaca acatcaccca gagcacccag tccttcaacg acttcaccag agtcgtgggc 600
ggcgaggatg ctaagcctgg ccagttcccg tggcaggtgg tgctgaacgg aaaggtggac 660
gccttctgcg gcggctccat cgtgaacgag aagtggatcg tgacagccgc ccactgcgtg 720
gaaaccggcg tgaagatcac agtggtggcc ggcgagcaca acatcgagga aaccgagcac 780
acagagcaga aaagaaacgt gatcaggatc atcccccacc acaactacaa cgccgccatc 840
aacaagtaca accacgatat cgccctgctg gaactggacg agcccctggt gctgaatagc 900
tacgtgaccc ccatctgtat cgccgacaaa gagtacacca acatctttct gaagttcggc 960
agcggctacg tgtccggctg gggcagagtg tttcacaagg gctactccgc tctggtgctg 1020
cagtacctga gagtgcctct ggtggacaga gccacctgtc tggaaagcac caagttcaga 1080
atctacaaca acatgttctg cgctggcttc cacgagggcg gcagagactc ttgtcagggc 1140
gattctggcg gccctcacgt gacagaggtg gaaggcacca gctttctgac cggcatcatc 1200
agctggggcg aggaatgcgc catgaagggg aagtacggca tctacaccaa ggtgtccaga 1260
tacgtgaact ggatcaaaga aaagaccaag ctgacataa                        1299

<210>  561
<211>  736
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LK03

<400>  561
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      

Glu Gly Ile Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro 
            20                  25                  30          

Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              

Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  

Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  

Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      

Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         

Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             

Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 

Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 

Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     

Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         

Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             

Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 

Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 

Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     

Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         

Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             

Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 

Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 

Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     

Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         

Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             

Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 

Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 

Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     

Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         

Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             

Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 

Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 

Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     

Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         

Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             

Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 

Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 

Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     

Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         

Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             

Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 

Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 

Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     

Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         

Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             

Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 

Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 

Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735

<210> 562
<211> 1857
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX R318Y/R338E/T343R optimized 1

<220> 
<221> intron         
<222> (1)...(163)

<220> 
<221> propeptide
<222> (164)...(214)

<220> 
<221> exon           
<222> (215)...(1459)

<220> 
<221> cloning vector
<222> (1468)...(1857)

<400> 562
gtatacagta ctgtgggaac atcacagatt ttggctccat gccctaaaga gaaattggct 60
ttcagattat ttggattaaa aacaaagact ttcttaagag atgtaaaatt ttcatgatgt 120
tttctttttt gctaaaacta aagaattatt cttttacatt tcagtttttc ttgaccatga 180
gaatgccaac aagatcctca acagacccaa gaggtacaac tcaggaaagt tggaagagtt 240
tgtgcagggc aacctggaga gagaatgcat ggaagaaaaa tgctcctttg aggaagccag 300
agaagtcttt gagaacactg agaggaccac tgaattctgg aagcaatatg tggatgggga 360
ccagtgtgaa agcaaccctt gcctcaatgg aggttcctgc aaggatgaca tcaacagcta 420
tgagtgctgg tgcccctttg gatttgaggg aaagaactgt gaacttgatg tgacctgtaa 480
catcaagaat gggagatgtg aacaattctg caagaactca gcagacaaca aggtggtctg 540
ctcctgcact gaggggtaca gacttgcaga aaaccagaaa agctgtgagc cagctgtccc 600
cttcccttgt gggagagtgt cagtgtctca aacctccaag ctgaccagag ctgaaactgt 660
gttccctgat gtggactatg tgaactccac tgaagcagaa accatcttgg acaacattac 720
ccagtccact cagagcttca atgacttcac cagagtggtg ggaggagaag atgccaagcc 780
tggccagttc ccttggcaag tggtcctcaa tggcaaagtg gatgccttct gtgggggctc 840
cattgtcaat gagaagtgga ttgtgactgc tgcccactgt gtggagactg gtgtcaagat 900
cactgtggtg gctggagaac acaacataga agagacagag cacactgagc agaagaggaa 960
tgtcatcagg atcattccac accacaacta caatgcagcc atcaacaagt acaaccatga 1020
cattgccttg ctggagctgg atgaaccact ggtgctgaac tcctatgtga cccccatttg 1080
cattgctgac aaggagtaca ccaacatttt cctgaagttt ggctcaggat atgtctcagg 1140
ctggggaaga gtgttccaca agggctactc agccctggtg ctgcagtacc tgagggtccc 1200
cctggtggac agagccacct gtctggaatc caccaagttc aggatctaca acaacatgtt 1260
ctgtgctgga ttccatgaag ggggcaggga cagctgccag ggagactcag gaggccccca 1320
tgtcactgaa gtggagggta cctccttcct gactggcatt atcagctggg gagaagaatg 1380
tgctatgaag gggaaatatg gaatctacac caaagtgtcc agatatgtga actggatcaa 1440
ggaaaagact aagctgacct aatgaaagat ggatttccaa ggttaattca ttggaattga 1500
aaattaacag cccccccccc ccccccctgc agatctcgag ccgaattcct gcagcccggg 1560
ggatcagcct cgactgtgcc ttctagttgc cagccatctg ttgtttgccc ctcccccgtg 1620
ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa tgaggaaatt 1680
gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg gcaggacagc 1740
aagggggagg attgggaaga caatagcagg catgctgggg atgcggtggg ctctatggct 1800
tctgaggcgg aaagaaccag ctggggctcg agatccacta gactagtgta cacgcgt    1857

<210> 563
<211> 1857
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX R318Y/R338E/T343R optimized 2

<220> 
<221> intron         
<222> (1)...(163)

<220> 
<221> propeptide
<222> (164)...(214)

<220> 
<221> exon           
<222> (215)...(1459)

<220> 
<221> cloning vector
<222> (1468)...(1857)

<400> 563
gtatacagta ctgtgggaac atcacagatt ttggctccat gccctaaaga gaaattggct 60
ttcagattat ttggattaaa aacaaagact ttcttaagag atgtaaaatt ttcatgatgt 120
tttctttttt gctaaaacta aagaattatt cttttacatt tcagtttttc ttgaccatga 180
aaatgccaac aagatcctca acaggcctaa gagatacaac tcaggaaagc tggaagaatt 240
tgtccagggc aacctggaaa gggaatgcat ggaagaaaag tgctcctttg aggaagccag 300
agaagtgttt gagaacactg aaaggaccac tgagttctgg aagcagtatg tggatggaga 360
tcagtgtgaa tccaacccct gcctcaatgg gggctcctgc aaagatgaca tcaactctta 420
tgagtgctgg tgcccttttg gatttgaggg caaaaactgt gaactggatg tgacctgtaa 480
tatcaagaat ggaagatgtg aacaattctg caagaactca gcagacaaca aagtggtctg 540
cagctgtact gaaggttaca gactggctga aaaccagaag tcctgtgaac cagcagtgcc 600
cttcccctgt ggaagagtct cagtcagcca gacctccaag ctgaccagag cagaaactgt 660
gttccctgat gtggattatg tgaacagcac tgaagctgaa accatcctgg acaacatcac 720
ccagtcaact cagtccttta atgatttcac cagagtagtg ggaggggaag atgcaaagcc 780
tggacagttc ccttggcaag tggtgctgaa tggcaaagtg gatgccttct gtgggggaag 840
cattgtgaat gagaagtgga ttgtgactgc tgcccactgt gtggagactg gtgtcaagat 900
tactgtggtg gcaggagaac acaacattga ggaaacagaa cacactgagc aaaagaggaa 960
tgtgataagg attatccccc accacaacta caatgcagcc atcaacaagt acaaccatga 1020
cattgccctg ctggagcttg atgaaccact ggtgctgaac tcatatgtga ccccaatctg 1080
cattgctgac aaggagtaca ccaacatctt cctgaagttt ggatcaggct atgtgtcagg 1140
ctggggaaga gtgttccaca agggctactc agccctggtg ctgcaatacc ttagagtgcc 1200
tctggtggac agagccactt gcttggagtc caccaagttc aggatctaca acaacatgtt 1260
ctgtgctggt ttccatgagg gaggcagaga cagctgccaa ggggactcag gaggacccca 1320
tgtcactgaa gtggagggaa ccagcttcct cactgggatc atctcctggg gagaagagtg 1380
tgccatgaag gggaaatatg ggatctacac caaagtctcc agatatgtca actggatcaa 1440
ggaaaagacc aagctcacct gatgaaagat ggatttccaa ggttaattca ttggaattga 1500
aaattaacag cccccccccc ccccccctgc agatctcgag ccgaattcct gcagcccggg 1560
ggatcagcct cgactgtgcc ttctagttgc cagccatctg ttgtttgccc ctcccccgtg 1620
ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa tgaggaaatt 1680
gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg gcaggacagc 1740
aagggggagg attgggaaga caatagcagg catgctgggg atgcggtggg ctctatggct 1800
tctgaggcgg aaagaaccag ctggggctcg agatccacta gactagtgta cacgcgt    1857

<210> 564
<211> 1857
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX R318Y/R338E/T343R optimized 3

<220> 
<221> intron         
<222> (1)...(163)

<220> 
<221> propeptide
<222> (164)...(214)

<220> 
<221> exon           
<222> (215)...(1459)

<220> 
<221> cloning vector
<222> (1468)...(1857)

<400> 564
gtatacagta ctgtgggaac atcacagatt ttggctccat gccctaaaga gaaattggct 60
ttcagattat ttggattaaa aacaaagact ttcttaagag atgtaaaatt ttcatgatgt 120
tttctttttt gctaaaacta aagaattatt cttttacatt tcagtttttc ttgaccatga 180
gaatgccaac aagatcttga acaggcccaa gagatacaac tcaggaaagc tggaagagtt 240
tgtgcagggg aacctggaga gagaatgcat ggaagaaaag tgctcctttg aggaagccag 300
agaagtgttt gaaaacactg agagaaccac tgagttctgg aaacaatatg tggatgggga 360
ccagtgtgaa agcaacccct gcctcaatgg aggctcctgc aaagatgaca ttaactccta 420
tgagtgctgg tgcccttttg gctttgaagg gaagaactgt gaattggatg tcacttgcaa 480
catcaagaat gggagatgtg aacagttctg caagaactca gctgacaaca aggtggtctg 540
ctcctgcact gaagggtaca ggctggcaga gaaccaaaaa tcctgtgaac cagcagtgcc 600
cttcccttgt gggagggtgt cagtcagcca aacctccaag ctgactaggg ctgaaactgt 660
gttccctgat gtggactatg tcaacagcac tgaggctgaa acaattctgg acaacatcac 720
ccagagcacc cagtccttta atgacttcac cagagtggtg ggaggagagg atgccaagcc 780
tggccagttc ccttggcaag tggtgctgaa tggaaaagtg gatgccttct gtggtggatc 840
cattgtcaat gagaaatgga ttgtgactgc tgcccactgt gtggagactg gagtcaagat 900
cacagtggtg gcaggagagc acaacattga ggaaactgag cacactgagc agaagaggaa 960
tgtcattagg atcatccccc accacaacta caatgctgcc attaacaagt acaaccatga 1020
cattgccctg cttgaactgg atgagcctct ggtcctcaac tcctatgtga cccccatctg 1080
cattgctgac aaggagtaca ccaacatctt cctcaagttt ggctcaggat atgtgtcagg 1140
ctggggcaga gtgttccaca aaggctactc agccttggtg ctgcaatacc tgagagtgcc 1200
cctggtggac agagccacct gtttggaatc cactaagttc aggatctaca acaacatgtt 1260
ctgtgctggc ttccatgagg gtggaagaga ctcctgccag ggagactctg gtggtcccca 1320
tgtcactgaa gtggaaggaa cctcattcct cactggcatc atcagctggg gtgaagagtg 1380
tgccatgaag gggaagtatg gcatctacac caaggtgtcc agatatgtga actggatcaa 1440
ggaaaagacc aagctgacct aatgaaagat ggatttccaa ggttaattca ttggaattga 1500
aaattaacag cccccccccc ccccccctgc agatctcgag ccgaattcct gcagcccggg 1560
ggatcagcct cgactgtgcc ttctagttgc cagccatctg ttgtttgccc ctcccccgtg 1620
ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa tgaggaaatt 1680
gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg gcaggacagc 1740
aagggggagg attgggaaga caatagcagg catgctgggg atgcggtggg ctctatggct 1800
tctgaggcgg aaagaaccag ctggggctcg agatccacta gactagtgta cacgcgt    1857

<210> 565
<211> 1858
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX R318Y/R338E/T343R non-optimized

<220> 
<221> intron         
<222> (1)...(163)

<220> 
<221> propeptide
<222> (164)...(214)

<220> 
<221> exon           
<222> (215)...(1459)

<220> 
<221> cloning vector
<222> (1468)...(1858)

<400> 565
gtatacagta ctgtgggaac atcacagatt ttggctccat gccctaaaga gaaattggct 60
ttcagattat ttggattaaa aacaaagact ttcttaagag atgtaaaatt ttcatgatgt 120
tttctttttt gctaaaacta aagaattatt cttttacatt tcagtttttc ttgatcatga 180
aaacgccaac aaaattctga atcggccaaa gaggtataat tcaggtaaat tggaagagtt 240
tgttcaaggg aaccttgaga gagaatgtat ggaagaaaag tgtagttttg aagaagcacg 300
agaagttttt gaaaacactg aaagaacaac tgaattttgg aagcagtatg ttgatggaga 360
tcagtgtgag tccaatccat gtttaaatgg cggcagttgc aaggatgaca ttaattccta 420
tgaatgttgg tgtccctttg gatttgaagg aaagaactgt gaattagatg taacatgtaa 480
cattaagaat ggcagatgcg agcagttttg taaaaatagt gctgataaca aggtggtttg 540
ctcctgtact gagggatatc gacttgcaga aaaccagaag tcctgtgaac cagcagtgcc 600
atttccatgt ggaagagttt ctgtttcaca aacttctaag ctcacccgtg ctgagactgt 660
ttttcctgat gtggactatg taaattctac tgaagctgaa accattttgg ataacatcac 720
tcaaagcacc caatcattta atgacttcac tcgggttgtt ggtggagaag atgccaaacc 780
aggtcaattc ccttggcagg ttgttttgaa tggtaaagtt gatgcattct gtggaggctc 840
tatcgttaat gaaaaatgga ttgtaactgc tgcccactgt gttgaaactg gtgttaaaat 900
tacagttgtc gcaggtgaac ataatattga ggagacagaa catacagagc aaaagcgaaa 960
tgtgattcga attattcctc accacaacta caatgcagct attaataagt acaaccatga 1020
cattgccctt ctggaactgg acgaaccctt agtgctaaac agctacgtta cacctatttg 1080
cattgctgac aaggaataca cgaacatctt cctcaaattt ggatctggct atgtaagtgg 1140
ctggggaaga gtcttccaca aagggtattc agctttagtt cttcagtacc ttagagttcc 1200
acttgttgac cgagccacat gtcttgaatc tacaaagttc agaatctata acaacatgtt 1260
ctgtgctggc ttccatgaag gaggtagaga ttcatgtcaa ggagatagtg ggggacccca 1320
tgttactgaa gtggaaggga ccagtttctt aactggaatt attagctggg gtgaagagtg 1380
tgcaatgaaa ggcaaatatg gaatatatac caaggtatcc cggtatgtca actggattaa 1440
ggaaaaaaca aagctcactt aatgaaagat ggatttccaa ggttaattca ttggaattga 1500
aaattaacag cccccccccc cccccccctg cagatctcga gccgaattcc tgcagcccgg 1560
gggatcagcc tcgactgtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt 1620
gccttccttg accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat 1680
tgcatcgcat tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag 1740
caagggggag gattgggaag acaatagcag gcatgctggg gatgcggtgg gctctatggc 1800
ttctgaggcg gaaagaacca gctggggctc gagatccact agactagtgt acacgcgt   1858

<210> 566
<211> 1857
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX R318Y/R338E/T343R optimized

<220> 
<221> intron         
<222> (1)...(163)

<220> 
<221> propeptide
<222> (164)...(214)

<220> 
<221> exon           
<222> (215)...(1459)

<220> 
<221> cloning vector
<222> (1468)...(1857)

<400> 566
gtatacagta ctgtgggaac atcacagatt ttggctccat gccctaaaga gaaattggct 60
ttcagattat ttggattaaa aacaaagact ttcttaagag atgtaaaatt ttcatgatgt 120
tttctttttt gctaaaacta aagaattatt cttttacatt tcagtttttc ttgatcatga 180
aaatgccaac aaaattctga ataggccaaa gaggtataat tcaggcaaat tggaagagtt 240
tgtgcaaggg aaccttgaga gagaatgtat ggaagaaaag tgtagttttg aagaagcaag 300
ggaagtgttt gaaaacactg aaagaacaac tgaattttgg aagcagtatg ttgatggaga 360
tcagtgtgag tccaatccat gtttaaatgg aggcagttgc aaggatgaca ttaattccta 420
tgaatgttgg tgtccctttg gatttgaagg aaagaactgt gaattagatg taacatgtaa 480
cattaagaat ggcagatgtg agcagttttg taaaaatagt gctgataaca aggtggtttg 540
ctcctgtact gagggatata ggcttgcaga aaaccagaag tcctgtgaac cagcagtgcc 600
atttccatgt ggaagagtgt ctgtgtcaca aacttctaag ctcaccagag ctgagactgt 660
ttttcctgat gtggactatg taaattctac tgaagctgaa accattttgg ataacatcac 720
tcaaagcacc caatcattta atgacttcac tagagttgtg ggtggagaag atgccaagcc 780
aggtcaattc ccttggcaag ttgttttgaa tggtaaagtt gatgcattct gtggaggctc 840
tattgttaat gaaaaatgga ttgtaactgc tgcccactgt gttgaaactg gtgttaaaat 900
tacagtggtg gcaggggaac ataatattga ggagacagaa catacagagc aaaagaggaa 960
tgtgattaga attattcctc accacaacta caatgcagct attaataagt acaaccatga 1020
cattgccctt ctggaactgg atgaaccctt agtgctaaac agctatgtta cacctatttg 1080
cattgctgac aaggaataca ccaacatctt cctcaaattt ggatctggct atgtaagtgg 1140
ctggggaaga gtgttccaca aagggtattc agctttagtt cttcagtacc ttagagtgcc 1200
acttgttgac agagccacat gtcttgaatc tacaaagttc agaatctata acaacatgtt 1260
ctgtgctggc ttccatgaag gaggtagaga ttcatgtcaa ggagatagtg ggggacccca 1320
tgttactgaa gtggaaggaa ccagtttctt aactggaatt attagctggg gtgaagagtg 1380
tgcaatgaaa ggcaaatatg gaatatatac caaggtatcc agatatgtca actggattaa 1440
ggaaaaaaca aagctcactt aatgaaagat ggatttccaa ggttaattca ttggaattga 1500
aaattaacag cccccccccc ccccccctgc agatctcgag ccgaattcct gcagcccggg 1560
ggatcagcct cgactgtgcc ttctagttgc cagccatctg ttgtttgccc ctcccccgtg 1620
ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa tgaggaaatt 1680
gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg gcaggacagc 1740
aagggggagg attgggaaga caatagcagg catgctgggg atgcggtggg ctctatggct 1800
tctgaggcgg aaagaaccag ctggggctcg agatccacta gactagtgta cacgcgt    1857


<210> 567
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Forward primer

<400> 567

atctacaaca acatgttctg cg                                          22


<210> 568
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reverse primer

<400> 568

ctgatgatgc cggtcagaaa                                             20


<210> 569
<211> 1245
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX R318Y/R338E/T343R mature optimized 1

<400> 569
tacaactcag gaaagttgga agagtttgtg cagggcaacc tggagagaga atgcatggaa 60
gaaaaatgct cctttgagga agccagagaa gtctttgaga acactgagag gaccactgaa 120
ttctggaagc aatatgtgga tggggaccag tgtgaaagca acccttgcct caatggaggt 180
tcctgcaagg atgacatcaa cagctatgag tgctggtgcc cctttggatt tgagggaaag 240
aactgtgaac ttgatgtgac ctgtaacatc aagaatggga gatgtgaaca attctgcaag 300
aactcagcag acaacaaggt ggtctgctcc tgcactgagg ggtacagact tgcagaaaac 360
cagaaaagct gtgagccagc tgtccccttc ccttgtggga gagtgtcagt gtctcaaacc 420
tccaagctga ccagagctga aactgtgttc cctgatgtgg actatgtgaa ctccactgaa 480
gcagaaacca tcttggacaa cattacccag tccactcaga gcttcaatga cttcaccaga 540
gtggtgggag gagaagatgc caagcctggc cagttccctt ggcaagtggt cctcaatggc 600
aaagtggatg ccttctgtgg gggctccatt gtcaatgaga agtggattgt gactgctgcc 660
cactgtgtgg agactggtgt caagatcact gtggtggctg gagaacacaa catagaagag 720
acagagcaca ctgagcagaa gaggaatgtc atcaggatca ttccacacca caactacaat 780
gcagccatca acaagtacaa ccatgacatt gccttgctgg agctggatga accactggtg 840
ctgaactcct atgtgacccc catttgcatt gctgacaagg agtacaccaa cattttcctg 900
aagtttggct caggatatgt ctcaggctgg ggaagagtgt tccacaaggg ctactcagcc 960
ctggtgctgc agtacctgag ggtccccctg gtggacagag ccacctgtct ggaatccacc 1020
aagttcagga tctacaacaa catgttctgt gctggattcc atgaaggggg cagggacagc 1080
tgccagggag actcaggagg cccccatgtc actgaagtgg agggtacctc cttcctgact 1140
ggcattatca gctggggaga agaatgtgct atgaagggga aatatggaat ctacaccaaa 1200
gtgtccagat atgtgaactg gatcaaggaa aagactaagc tgacc                 1245

<210> 570
<211> 1245
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX R318Y/R338E/T343R mature optimized 2

<400> 570
tacaactcag gaaagctgga agaatttgtc cagggcaacc tggaaaggga atgcatggaa 60
gaaaagtgct cctttgagga agccagagaa gtgtttgaga acactgaaag gaccactgag 120
ttctggaagc agtatgtgga tggagatcag tgtgaatcca acccctgcct caatgggggc 180
tcctgcaaag atgacatcaa ctcttatgag tgctggtgcc cttttggatt tgagggcaaa 240
aactgtgaac tggatgtgac ctgtaatatc aagaatggaa gatgtgaaca attctgcaag 300
aactcagcag acaacaaagt ggtctgcagc tgtactgaag gttacagact ggctgaaaac 360
cagaagtcct gtgaaccagc agtgcccttc ccctgtggaa gagtctcagt cagccagacc 420
tccaagctga ccagagcaga aactgtgttc cctgatgtgg attatgtgaa cagcactgaa 480
gctgaaacca tcctggacaa catcacccag tcaactcagt cctttaatga tttcaccaga 540
gtagtgggag gggaagatgc aaagcctgga cagttccctt ggcaagtggt gctgaatggc 600
aaagtggatg ccttctgtgg gggaagcatt gtgaatgaga agtggattgt gactgctgcc 660
cactgtgtgg agactggtgt caagattact gtggtggcag gagaacacaa cattgaggaa 720
acagaacaca ctgagcaaaa gaggaatgtg ataaggatta tcccccacca caactacaat 780
gcagccatca acaagtacaa ccatgacatt gccctgctgg agcttgatga accactggtg 840
ctgaactcat atgtgacccc aatctgcatt gctgacaagg agtacaccaa catcttcctg 900
aagtttggat caggctatgt gtcaggctgg ggaagagtgt tccacaaggg ctactcagcc 960
ctggtgctgc aataccttag agtgcctctg gtggacagag ccacttgctt ggagtccacc 1020
aagttcagga tctacaacaa catgttctgt gctggtttcc atgagggagg cagagacagc 1080
tgccaagggg actcaggagg accccatgtc actgaagtgg agggaaccag cttcctcact 1140
gggatcatct cctggggaga agagtgtgcc atgaagggga aatatgggat ctacaccaaa 1200
gtctccagat atgtcaactg gatcaaggaa aagaccaagc tcacc                 1245

<210> 571
<211> 1245
<212> DNA
<213> Artificial Sequence

<220> 
<223> human FIX R318Y/R338E/T343R mature optimized 3

<400> 571
tacaactcag gaaagctgga agagtttgtg caggggaacc tggagagaga atgcatggaa 60
gaaaagtgct cctttgagga agccagagaa gtgtttgaaa acactgagag aaccactgag 120
ttctggaaac aatatgtgga tggggaccag tgtgaaagca acccctgcct caatggaggc 180
tcctgcaaag atgacattaa ctcctatgag tgctggtgcc cttttggctt tgaagggaag 240
aactgtgaat tggatgtcac ttgcaacatc aagaatggga gatgtgaaca gttctgcaag 300
aactcagctg acaacaaggt ggtctgctcc tgcactgaag ggtacaggct ggcagagaac 360
caaaaatcct gtgaaccagc agtgcccttc ccttgtggga gggtgtcagt cagccaaacc 420
tccaagctga ctagggctga aactgtgttc cctgatgtgg actatgtcaa cagcactgag 480
gctgaaacaa ttctggacaa catcacccag agcacccagt cctttaatga cttcaccaga 540
gtggtgggag gagaggatgc caagcctggc cagttccctt ggcaagtggt gctgaatgga 600
aaagtggatg ccttctgtgg tggatccatt gtcaatgaga aatggattgt gactgctgcc 660
cactgtgtgg agactggagt caagatcaca gtggtggcag gagagcacaa cattgaggaa 720
actgagcaca ctgagcagaa gaggaatgtc attaggatca tcccccacca caactacaat 780
gctgccatta acaagtacaa ccatgacatt gccctgcttg aactggatga gcctctggtc 840
ctcaactcct atgtgacccc catctgcatt gctgacaagg agtacaccaa catcttcctc 900
aagtttggct caggatatgt gtcaggctgg ggcagagtgt tccacaaagg ctactcagcc 960
ttggtgctgc aatacctgag agtgcccctg gtggacagag ccacctgttt ggaatccact 1020
aagttcagga tctacaacaa catgttctgt gctggcttcc atgagggtgg aagagactcc 1080
tgccagggag actctggtgg tccccatgtc actgaagtgg aaggaacctc attcctcact 1140
ggcatcatca gctggggtga agagtgtgcc atgaagggga agtatggcat ctacaccaag 1200
gtgtccagat atgtgaactg gatcaaggaa aagaccaagc tgacc                 1245

<210> 572
<211> 7585
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV-hFIX (R318Y/R338E/T343R) optimized 1

<220> 
<221> repeat_region  
<222> (1597)...(1715)
<223> ITR

<220> 
<221> enhancer       
<222> (1781)...(2101)
<223> ApoE/C1

<220> 
<221> promoter       
<222> (2111)...(2503)
<223> huSerpin A antitrypsin liver specific promoter
      (partial)

<220> 
<221> misc_feature   
<222> (2598)...(2603)
<223> kozak


<220> 
<221> sig_peptide    
<222> (2604)...(2687)
<223> FIX signal sequence


<220> 
<221> misc_feature 
<222> (2688)...(2690) 
<223> FIX propeptide sequence


<220> 
<221> intron         
<222> (2691)...(4128)
<223> FIX partial intron 1


<220> 
<221> misc_feature 
<222> (4129)...(4179) 
<223> FIX propeptide sequence


<220> 
<221> misc_feature 
<222> (4180)...(5424) 
<223> FIX Zymogen


<220> 
<221> polyA_signal   
<222> (5539)...(5763)
<223> bovine growth hormone polyadenylation signal


<220> 
<221> repeat_region  
<222> (5877)...(6006)
<223> ITR

<400> 572
gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg 60
acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg 120
gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag 180
ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg 240
gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct 300
cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac 360
agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact 420
catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga 480
tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt 540
cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct 600
gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc 660
taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc 720
ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc 780
tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg 840
ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt 900
cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg 960
agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg 1020
gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt 1080
atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag 1140
gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt 1200
gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta 1260
ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt 1320
cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc 1380
cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca 1440
acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc 1500
cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg 1560
accatgatta cgccaagctt gcatgcctgc aggcagctgc gcgctcgctc gctcactgag 1620
gccgcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag 1680
agagggagtg gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtaaag 1740
atctgatatc atcgatcgcg atgcattaat taagcggccg aggctcagag gcacacagga 1800
gtttctgggc tcaccctgcc cccttccaac ccctcagttc ccatcctcca gcagctgttt 1860
gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc tactcatgtc cctaaaatgg 1920
gcaaacattg caagcagcaa acagcaaaca cacagccctc cctgcctgct gaccttggag 1980
ctggggcaga ggtcagagac ctctctgggc ccatgccacc tccaacatcc actcgacccc 2040
ttggaatttc ggtggagagg agcagaggtt gtcctggcgt ggtttaggta gtgtgagagg 2100
ggtacccggg gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga 2160
gggccagcta agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg 2220
gacacaggac gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg 2280
aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag 2340
ccagtggact tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca 2400
ccagcagcct cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc 2460
cctgtctcct cagcttcagg caccaccact gacctgggac agtgaatgat ccccctgatc 2520
tgcggcctcg acggtatcga taagcttgat atcgaattct agtcgtcgac cactttcaca 2580
atctgctagc aaaggttgcc accatgcagc gcgtgaacat gatcatggca gaatcaccag 2640
gcctcatcac catctgcctt ttaggatatc tactcagtgc tgaatgtaca ggtttgtttc 2700
cttttttaaa atacattgag tatgcttgcc ttttagatat agaaatatct gatgctgtct 2760
tcttcactaa attttgatta catgatttga cagcaatatt gaagagtcta acagccagca 2820
cgcaggttgg taagtactgg ttctttgtta gctaggtttt cttcttcttc atttttaaaa 2880
ctaaatagat cgacaatgct tatgatgcat ttatgtttaa taaacactgt tcagttcatg 2940
atttggtcat gtaattcctg ttagaaaaca ttcatctcct tggtttaaaa aaattaaaag 3000
tgggaaaaca aagaaatagc agaatatagt gaaaaaaaat aaccacatta tttttgtttg 3060
gacttaccac tttgaaatca aaatgggaaa caaaagcaca aacaatggcc ttatttacac 3120
aaaaagtctg attttaagat atatgacatt tcaaggtttc agaagtatgt aatgaggtgt 3180
gtctctaatt ttttaaatta tatatcttca atttaaagtt ttagttaaaa cataaagatt 3240
aacctttcat tagcaagctg ttagttatca ccaaagcttt tcatggatta ggaaaaaatc 3300
attttgtctc tatgtcaaac atcttggagt tgatatttgg ggaaacacaa tactcagttg 3360
agttccctag gggagaaaag caagcttaag aattgacata aagagtagga agttagctaa 3420
tgcaacatat atcactttgt tttttcacaa ctacagtgac tttatgtatt tcccagagga 3480
aggcatacag ggaagaaatt atcccatttg gacaaacagc atgttctcac aggaagcatt 3540
tatcacactt acttgtcaac tttctagaat caaatctagt agctgacagt accaggatca 3600
ggggtgccaa ccctaagcac ccccagaaag ctgactggcc ctgtggttcc cactccagac 3660
atgatgtcag ctgtgaaatc gacgtcgctg gaccataatt aggcttctgt tcttcaggag 3720
acatttgttc aaagtcattt gggcaaccat attctgaaaa cagcccagcc agggtgatgg 3780
atcactttgc aaagatcctc aatgagctat tttcaagtga tgacaaagtg tgaagttaac 3840
cgctcatttg agaactttct ttttcatcca aagtaaattc aaatatgatt agaaatctga 3900
ccttttatta ctggaattct cttgactaaa agtaaaattg aattttaatt cctaaatctc 3960
catgtgtata cagtactgtg ggaacatcac agattttggc tccatgccct aaagagaaat 4020
tggctttcag attatttgga ttaaaaacaa agactttctt aagagatgta aaattttcat 4080
gatgttttct tttttgctaa aactaaagaa ttattctttt acatttcagt ttttcttgac 4140
catgagaatg ccaacaagat cctcaacaga cccaagaggt acaactcagg aaagttggaa 4200
gagtttgtgc agggcaacct ggagagagaa tgcatggaag aaaaatgctc ctttgaggaa 4260
gccagagaag tctttgagaa cactgagagg accactgaat tctggaagca atatgtggat 4320
ggggaccagt gtgaaagcaa cccttgcctc aatggaggtt cctgcaagga tgacatcaac 4380
agctatgagt gctggtgccc ctttggattt gagggaaaga actgtgaact tgatgtgacc 4440
tgtaacatca agaatgggag atgtgaacaa ttctgcaaga actcagcaga caacaaggtg 4500
gtctgctcct gcactgaggg gtacagactt gcagaaaacc agaaaagctg tgagccagct 4560
gtccccttcc cttgtgggag agtgtcagtg tctcaaacct ccaagctgac cagagctgaa 4620
actgtgttcc ctgatgtgga ctatgtgaac tccactgaag cagaaaccat cttggacaac 4680
attacccagt ccactcagag cttcaatgac ttcaccagag tggtgggagg agaagatgcc 4740
aagcctggcc agttcccttg gcaagtggtc ctcaatggca aagtggatgc cttctgtggg 4800
ggctccattg tcaatgagaa gtggattgtg actgctgccc actgtgtgga gactggtgtc 4860
aagatcactg tggtggctgg agaacacaac atagaagaga cagagcacac tgagcagaag 4920
aggaatgtca tcaggatcat tccacaccac aactacaatg cagccatcaa caagtacaac 4980
catgacattg ccttgctgga gctggatgaa ccactggtgc tgaactccta tgtgaccccc 5040
atttgcattg ctgacaagga gtacaccaac attttcctga agtttggctc aggatatgtc 5100
tcaggctggg gaagagtgtt ccacaagggc tactcagccc tggtgctgca gtacctgagg 5160
gtccccctgg tggacagagc cacctgtctg gaatccacca agttcaggat ctacaacaac 5220
atgttctgtg ctggattcca tgaagggggc agggacagct gccagggaga ctcaggaggc 5280
ccccatgtca ctgaagtgga gggtacctcc ttcctgactg gcattatcag ctggggagaa 5340
gaatgtgcta tgaaggggaa atatggaatc tacaccaaag tgtccagata tgtgaactgg 5400
atcaaggaaa agactaagct gacctaatga aagatggatt tccaaggtta attcattgga 5460
attgaaaatt aacagccccc cccccccccc cctgcagatc tcgagccgaa ttcctgcagc 5520
ccgggggatc agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc 5580
ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg 5640
aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg 5700
acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta 5760
tggcttctga ggcggaaaga accagctggg gctcgagatc cactagacta gtgtacacgc 5820
gtgatatcag atctgttacg tagataagta gcatggcggg ttaatcatta actacaagga 5880
acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg 5940
gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc 6000
gcgcagctgc ctgcaggtcg actctagagg atccccgggt accgagctcg aattcactgg 6060
ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg 6120
cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt 6180
cccaacagtt gcgcagcctg aatggcgaat ggcgcctgat gcggtatttt ctccttacgc 6240
atctgtgcgg tatttcacac cgcatacgtc aaagcaacca tagtacgcgc cctgtagcgg 6300
cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc 6360
ttagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc 6420
cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc 6480
gaccccaaaa aacttgattt gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg 6540
gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact 6600
ggaacaacac tcaactctat ctcgggctat tcttttgatt tataagggat tttgccgatt 6660
tcggtctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa 6720
atattaacgt ttacaatttt atggtgcact ctcagtacaa tctgctctga tgccgcatag 6780
ttaagccagc cccgacaccc gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc 6840
ccggcatccg cttacagaca agctgtgacc gtctccggga gctgcatgtg tcagaggttt 6900
tcaccgtcat caccgaaacg cgcgagacga aagggcctcg tgatacgcct atttttatag 6960
gttaatgtca tgataataat ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg 7020
cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga 7080
caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat 7140
ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca 7200
gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc 7260
gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca 7320
atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg 7380
caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca 7440
gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata 7500
accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag 7560
ctaaccgctt ttttgcacaa catgg                                       7585



<210> 573
<211> 7585
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV-hFIX (R318Y/R338E/T343R) optimized 2

<220> 
<221> repeat_region  
<222> (1597)...(1715)
<223> ITR

<220> 
<221> enhancer       
<222> (1781)...(2101)
<223> ApoE/C1

<220> 
<221> promoter       
<222> (2111)...(2503)
<223> huSerpin A antitrypsin liver specific promoter
      (partial)

<220> 
<221> misc_feature   
<222> (2598)...(2603)
<223> kozak


<220> 
<221> sig_peptide    
<222> (2604)...(2687)
<223> FIX signal sequence


<220> 
<221> misc_feature 
<222> (2688)...(2690) 
<223> FIX propeptide sequence


<220> 
<221> intron         
<222> (2691)...(4128)
<223> FIX partial intron 1


<220> 
<221> misc_feature 
<222> (4129)...(4179) 
<223> FIX propeptide sequence


<220> 
<221> misc_feature 
<222> (4180)...(5424) 
<223> FIX Zymogen


<220> 
<221> polyA_signal   
<222> (5539)...(5763)
<223> bovine growth hormone polyadenylation signal


<220> 
<221> repeat_region  
<222> (5877)...(6006)
<223> ITR

<400> 573
gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg 60
acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg 120
gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag 180
ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg 240
gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct 300
cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac 360
agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact 420
catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga 480
tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt 540
cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct 600
gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc 660
taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc 720
ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc 780
tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg 840
ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt 900
cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg 960
agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg 1020
gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt 1080
atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag 1140
gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt 1200
gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta 1260
ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt 1320
cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc 1380
cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca 1440
acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc 1500
cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg 1560
accatgatta cgccaagctt gcatgcctgc aggcagctgc gcgctcgctc gctcactgag 1620
gccgcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag 1680
agagggagtg gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtaaag 1740
atctgatatc atcgatcgcg atgcattaat taagcggccg aggctcagag gcacacagga 1800
gtttctgggc tcaccctgcc cccttccaac ccctcagttc ccatcctcca gcagctgttt 1860
gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc tactcatgtc cctaaaatgg 1920
gcaaacattg caagcagcaa acagcaaaca cacagccctc cctgcctgct gaccttggag 1980
ctggggcaga ggtcagagac ctctctgggc ccatgccacc tccaacatcc actcgacccc 2040
ttggaatttc ggtggagagg agcagaggtt gtcctggcgt ggtttaggta gtgtgagagg 2100
ggtacccggg gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga 2160
gggccagcta agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg 2220
gacacaggac gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg 2280
aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag 2340
ccagtggact tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca 2400
ccagcagcct cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc 2460
cctgtctcct cagcttcagg caccaccact gacctgggac agtgaatgat ccccctgatc 2520
tgcggcctcg acggtatcga taagcttgat atcgaattct agtcgtcgac cactttcaca 2580
atctgctagc aaaggttgcc accatgcagc gcgtgaacat gatcatggca gaatcaccag 2640
gcctcatcac catctgcctt ttaggatatc tactcagtgc tgaatgtaca ggtttgtttc 2700
cttttttaaa atacattgag tatgcttgcc ttttagatat agaaatatct gatgctgtct 2760
tcttcactaa attttgatta catgatttga cagcaatatt gaagagtcta acagccagca 2820
cgcaggttgg taagtactgg ttctttgtta gctaggtttt cttcttcttc atttttaaaa 2880
ctaaatagat cgacaatgct tatgatgcat ttatgtttaa taaacactgt tcagttcatg 2940
atttggtcat gtaattcctg ttagaaaaca ttcatctcct tggtttaaaa aaattaaaag 3000
tgggaaaaca aagaaatagc agaatatagt gaaaaaaaat aaccacatta tttttgtttg 3060
gacttaccac tttgaaatca aaatgggaaa caaaagcaca aacaatggcc ttatttacac 3120
aaaaagtctg attttaagat atatgacatt tcaaggtttc agaagtatgt aatgaggtgt 3180
gtctctaatt ttttaaatta tatatcttca atttaaagtt ttagttaaaa cataaagatt 3240
aacctttcat tagcaagctg ttagttatca ccaaagcttt tcatggatta ggaaaaaatc 3300
attttgtctc tatgtcaaac atcttggagt tgatatttgg ggaaacacaa tactcagttg 3360
agttccctag gggagaaaag caagcttaag aattgacata aagagtagga agttagctaa 3420
tgcaacatat atcactttgt tttttcacaa ctacagtgac tttatgtatt tcccagagga 3480
aggcatacag ggaagaaatt atcccatttg gacaaacagc atgttctcac aggaagcatt 3540
tatcacactt acttgtcaac tttctagaat caaatctagt agctgacagt accaggatca 3600
ggggtgccaa ccctaagcac ccccagaaag ctgactggcc ctgtggttcc cactccagac 3660
atgatgtcag ctgtgaaatc gacgtcgctg gaccataatt aggcttctgt tcttcaggag 3720
acatttgttc aaagtcattt gggcaaccat attctgaaaa cagcccagcc agggtgatgg 3780
atcactttgc aaagatcctc aatgagctat tttcaagtga tgacaaagtg tgaagttaac 3840
cgctcatttg agaactttct ttttcatcca aagtaaattc aaatatgatt agaaatctga 3900
ccttttatta ctggaattct cttgactaaa agtaaaattg aattttaatt cctaaatctc 3960
catgtgtata cagtactgtg ggaacatcac agattttggc tccatgccct aaagagaaat 4020
tggctttcag attatttgga ttaaaaacaa agactttctt aagagatgta aaattttcat 4080
gatgttttct tttttgctaa aactaaagaa ttattctttt acatttcagt ttttcttgac 4140
catgaaaatg ccaacaagat cctcaacagg cctaagagat acaactcagg aaagctggaa 4200
gaatttgtcc agggcaacct ggaaagggaa tgcatggaag aaaagtgctc ctttgaggaa 4260
gccagagaag tgtttgagaa cactgaaagg accactgagt tctggaagca gtatgtggat 4320
ggagatcagt gtgaatccaa cccctgcctc aatgggggct cctgcaaaga tgacatcaac 4380
tcttatgagt gctggtgccc ttttggattt gagggcaaaa actgtgaact ggatgtgacc 4440
tgtaatatca agaatggaag atgtgaacaa ttctgcaaga actcagcaga caacaaagtg 4500
gtctgcagct gtactgaagg ttacagactg gctgaaaacc agaagtcctg tgaaccagca 4560
gtgcccttcc cctgtggaag agtctcagtc agccagacct ccaagctgac cagagcagaa 4620
actgtgttcc ctgatgtgga ttatgtgaac agcactgaag ctgaaaccat cctggacaac 4680
atcacccagt caactcagtc ctttaatgat ttcaccagag tagtgggagg ggaagatgca 4740
aagcctggac agttcccttg gcaagtggtg ctgaatggca aagtggatgc cttctgtggg 4800
ggaagcattg tgaatgagaa gtggattgtg actgctgccc actgtgtgga gactggtgtc 4860
aagattactg tggtggcagg agaacacaac attgaggaaa cagaacacac tgagcaaaag 4920
aggaatgtga taaggattat cccccaccac aactacaatg cagccatcaa caagtacaac 4980
catgacattg ccctgctgga gcttgatgaa ccactggtgc tgaactcata tgtgacccca 5040
atctgcattg ctgacaagga gtacaccaac atcttcctga agtttggatc aggctatgtg 5100
tcaggctggg gaagagtgtt ccacaagggc tactcagccc tggtgctgca ataccttaga 5160
gtgcctctgg tggacagagc cacttgcttg gagtccacca agttcaggat ctacaacaac 5220
atgttctgtg ctggtttcca tgagggaggc agagacagct gccaagggga ctcaggagga 5280
ccccatgtca ctgaagtgga gggaaccagc ttcctcactg ggatcatctc ctggggagaa 5340
gagtgtgcca tgaaggggaa atatgggatc tacaccaaag tctccagata tgtcaactgg 5400
atcaaggaaa agaccaagct cacctaatga aagatggatt tccaaggtta attcattgga 5460
attgaaaatt aacagccccc cccccccccc cctgcagatc tcgagccgaa ttcctgcagc 5520
ccgggggatc agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc 5580
ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg 5640
aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg 5700
acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta 5760
tggcttctga ggcggaaaga accagctggg gctcgagatc cactagacta gtgtacacgc 5820
gtgatatcag atctgttacg tagataagta gcatggcggg ttaatcatta actacaagga 5880
acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg 5940
gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc 6000
gcgcagctgc ctgcaggtcg actctagagg atccccgggt accgagctcg aattcactgg 6060
ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg 6120
cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt 6180
cccaacagtt gcgcagcctg aatggcgaat ggcgcctgat gcggtatttt ctccttacgc 6240
atctgtgcgg tatttcacac cgcatacgtc aaagcaacca tagtacgcgc cctgtagcgg 6300
cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc 6360
ttagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc 6420
cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc 6480
gaccccaaaa aacttgattt gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg 6540
gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact 6600
ggaacaacac tcaactctat ctcgggctat tcttttgatt tataagggat tttgccgatt 6660
tcggtctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa 6720
atattaacgt ttacaatttt atggtgcact ctcagtacaa tctgctctga tgccgcatag 6780
ttaagccagc cccgacaccc gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc 6840
ccggcatccg cttacagaca agctgtgacc gtctccggga gctgcatgtg tcagaggttt 6900
tcaccgtcat caccgaaacg cgcgagacga aagggcctcg tgatacgcct atttttatag 6960
gttaatgtca tgataataat ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg 7020
cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga 7080
caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat 7140
ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca 7200
gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc 7260
gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca 7320
atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg 7380
caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca 7440
gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata 7500
accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag 7560
ctaaccgctt ttttgcacaa catgg                                       7585



<210> 574
<211> 7585
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV-hFIX (R318Y/R338E/T343R) optimized 3

<220> 
<221> repeat_region  
<222> (1597)...(1715)
<223> ITR

<220> 
<221> enhancer       
<222> (1781)...(2101)
<223> ApoE/C1

<220> 
<221> promoter       
<222> (2111)...(2503)
<223> huSerpin A antitrypsin liver specific promoter
      (partial)

<220> 
<221> misc_feature   
<222> (2598)...(2603)
<223> kozak


<220> 
<221> sig_peptide    
<222> (2604)...(2687)
<223> FIX signal sequence


<220> 
<221> misc_feature 
<222> (2688)...(2690) 
<223> FIX propeptide sequence


<220> 
<221> intron         
<222> (2691)...(4128)
<223> FIX partial intron 1


<220> 
<221> misc_feature 
<222> (4129)...(4179) 
<223> FIX propeptide sequence


<220> 
<221> misc_feature 
<222> (4180)...(5424) 
<223> FIX Zymogen


<220> 
<221> polyA_signal   
<222> (5539)...(5763)
<223> bovine growth hormone polyadenylation signal


<220> 
<221> repeat_region  
<222> (5877)...(6006)
<223> ITR

<400> 574
gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg 60
acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg 120
gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag 180
ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg 240
gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct 300
cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac 360
agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact 420
catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga 480
tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt 540
cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct 600
gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc 660
taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc 720
ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc 780
tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg 840
ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt 900
cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg 960
agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg 1020
gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt 1080
atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag 1140
gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt 1200
gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta 1260
ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt 1320
cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc 1380
cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca 1440
acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc 1500
cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg 1560
accatgatta cgccaagctt gcatgcctgc aggcagctgc gcgctcgctc gctcactgag 1620
gccgcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag 1680
agagggagtg gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtaaag 1740
atctgatatc atcgatcgcg atgcattaat taagcggccg aggctcagag gcacacagga 1800
gtttctgggc tcaccctgcc cccttccaac ccctcagttc ccatcctcca gcagctgttt 1860
gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc tactcatgtc cctaaaatgg 1920
gcaaacattg caagcagcaa acagcaaaca cacagccctc cctgcctgct gaccttggag 1980
ctggggcaga ggtcagagac ctctctgggc ccatgccacc tccaacatcc actcgacccc 2040
ttggaatttc ggtggagagg agcagaggtt gtcctggcgt ggtttaggta gtgtgagagg 2100
ggtacccggg gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga 2160
gggccagcta agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg 2220
gacacaggac gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg 2280
aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag 2340
ccagtggact tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca 2400
ccagcagcct cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc 2460
cctgtctcct cagcttcagg caccaccact gacctgggac agtgaatgat ccccctgatc 2520
tgcggcctcg acggtatcga taagcttgat atcgaattct agtcgtcgac cactttcaca 2580
atctgctagc aaaggttgcc accatgcagc gcgtgaacat gatcatggca gaatcaccag 2640
gcctcatcac catctgcctt ttaggatatc tactcagtgc tgaatgtaca ggtttgtttc 2700
cttttttaaa atacattgag tatgcttgcc ttttagatat agaaatatct gatgctgtct 2760
tcttcactaa attttgatta catgatttga cagcaatatt gaagagtcta acagccagca 2820
cgcaggttgg taagtactgg ttctttgtta gctaggtttt cttcttcttc atttttaaaa 2880
ctaaatagat cgacaatgct tatgatgcat ttatgtttaa taaacactgt tcagttcatg 2940
atttggtcat gtaattcctg ttagaaaaca ttcatctcct tggtttaaaa aaattaaaag 3000
tgggaaaaca aagaaatagc agaatatagt gaaaaaaaat aaccacatta tttttgtttg 3060
gacttaccac tttgaaatca aaatgggaaa caaaagcaca aacaatggcc ttatttacac 3120
aaaaagtctg attttaagat atatgacatt tcaaggtttc agaagtatgt aatgaggtgt 3180
gtctctaatt ttttaaatta tatatcttca atttaaagtt ttagttaaaa cataaagatt 3240
aacctttcat tagcaagctg ttagttatca ccaaagcttt tcatggatta ggaaaaaatc 3300
attttgtctc tatgtcaaac atcttggagt tgatatttgg ggaaacacaa tactcagttg 3360
agttccctag gggagaaaag caagcttaag aattgacata aagagtagga agttagctaa 3420
tgcaacatat atcactttgt tttttcacaa ctacagtgac tttatgtatt tcccagagga 3480
aggcatacag ggaagaaatt atcccatttg gacaaacagc atgttctcac aggaagcatt 3540
tatcacactt acttgtcaac tttctagaat caaatctagt agctgacagt accaggatca 3600
ggggtgccaa ccctaagcac ccccagaaag ctgactggcc ctgtggttcc cactccagac 3660
atgatgtcag ctgtgaaatc gacgtcgctg gaccataatt aggcttctgt tcttcaggag 3720
acatttgttc aaagtcattt gggcaaccat attctgaaaa cagcccagcc agggtgatgg 3780
atcactttgc aaagatcctc aatgagctat tttcaagtga tgacaaagtg tgaagttaac 3840
cgctcatttg agaactttct ttttcatcca aagtaaattc aaatatgatt agaaatctga 3900
ccttttatta ctggaattct cttgactaaa agtaaaattg aattttaatt cctaaatctc 3960
catgtgtata cagtactgtg ggaacatcac agattttggc tccatgccct aaagagaaat 4020
tggctttcag attatttgga ttaaaaacaa agactttctt aagagatgta aaattttcat 4080
gatgttttct tttttgctaa aactaaagaa ttattctttt acatttcagt ttttcttgac 4140
catgagaatg ccaacaagat cttgaacagg cccaagagat acaactcagg aaagctggaa 4200
gagtttgtgc aggggaacct ggagagagaa tgcatggaag aaaagtgctc ctttgaggaa 4260
gccagagaag tgtttgaaaa cactgagaga accactgagt tctggaaaca atatgtggat 4320
ggggaccagt gtgaaagcaa cccctgcctc aatggaggct cctgcaaaga tgacattaac 4380
tcctatgagt gctggtgccc ttttggcttt gaagggaaga actgtgaatt ggatgtcact 4440
tgcaacatca agaatgggag atgtgaacag ttctgcaaga actcagctga caacaaggtg 4500
gtctgctcct gcactgaagg gtacaggctg gcagagaacc aaaaatcctg tgaaccagca 4560
gtgcccttcc cttgtgggag ggtgtcagtc agccaaacct ccaagctgac tagggctgaa 4620
actgtgttcc ctgatgtgga ctatgtcaac agcactgagg ctgaaacaat tctggacaac 4680
atcacccaga gcacccagtc ctttaatgac ttcaccagag tggtgggagg agaggatgcc 4740
aagcctggcc agttcccttg gcaagtggtg ctgaatggaa aagtggatgc cttctgtggt 4800
ggatccattg tcaatgagaa atggattgtg actgctgccc actgtgtgga gactggagtc 4860
aagatcacag tggtggcagg agagcacaac attgaggaaa ctgagcacac tgagcagaag 4920
aggaatgtca ttaggatcat cccccaccac aactacaatg ctgccattaa caagtacaac 4980
catgacattg ccctgcttga actggatgag cctctggtcc tcaactccta tgtgaccccc 5040
atctgcattg ctgacaagga gtacaccaac atcttcctca agtttggctc aggatatgtg 5100
tcaggctggg gcagagtgtt ccacaaaggc tactcagcct tggtgctgca atacctgaga 5160
gtgcccctgg tggacagagc cacctgtttg gaatccacta agttcaggat ctacaacaac 5220
atgttctgtg ctggcttcca tgagggtgga agagactcct gccagggaga ctctggtggt 5280
ccccatgtca ctgaagtgga aggaacctca ttcctcactg gcatcatcag ctggggtgaa 5340
gagtgtgcca tgaaggggaa gtatggcatc tacaccaagg tgtccagata tgtgaactgg 5400
atcaaggaaa agaccaagct gacctaatga aagatggatt tccaaggtta attcattgga 5460
attgaaaatt aacagccccc cccccccccc cctgcagatc tcgagccgaa ttcctgcagc 5520
ccgggggatc agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc 5580
ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg 5640
aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg 5700
acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta 5760
tggcttctga ggcggaaaga accagctggg gctcgagatc cactagacta gtgtacacgc 5820
gtgatatcag atctgttacg tagataagta gcatggcggg ttaatcatta actacaagga 5880
acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg 5940
gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc 6000
gcgcagctgc ctgcaggtcg actctagagg atccccgggt accgagctcg aattcactgg 6060
ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg 6120
cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt 6180
cccaacagtt gcgcagcctg aatggcgaat ggcgcctgat gcggtatttt ctccttacgc 6240
atctgtgcgg tatttcacac cgcatacgtc aaagcaacca tagtacgcgc cctgtagcgg 6300
cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc 6360
ttagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc 6420
cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc 6480
gaccccaaaa aacttgattt gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg 6540
gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact 6600
ggaacaacac tcaactctat ctcgggctat tcttttgatt tataagggat tttgccgatt 6660
tcggtctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa 6720
atattaacgt ttacaatttt atggtgcact ctcagtacaa tctgctctga tgccgcatag 6780
ttaagccagc cccgacaccc gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc 6840
ccggcatccg cttacagaca agctgtgacc gtctccggga gctgcatgtg tcagaggttt 6900
tcaccgtcat caccgaaacg cgcgagacga aagggcctcg tgatacgcct atttttatag 6960
gttaatgtca tgataataat ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg 7020
cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga 7080
caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat 7140
ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca 7200
gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc 7260
gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca 7320
atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg 7380
caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca 7440
gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata 7500
accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag 7560
ctaaccgctt ttttgcacaa catgg                                       7585


<210> 575
<211> 7585
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV-hFIX (R318Y/R338E/T343R) optimized

<220> 
<221> repeat_region  
<222> (1597)...(1715)
<223> ITR

<220> 
<221> enhancer       
<222> (1781)...(2101)
<223> ApoE/C1

<220> 
<221> promoter       
<222> (2111)...(2503)
<223> huSerpin A antitrypsin liver specific promoter
      (partial)

<220> 
<221> misc_feature   
<222> (2598)...(2603)
<223> kozak


<220> 
<221> sig_peptide    
<222> (2604)...(2687)
<223> FIX signal sequence


<220> 
<221> misc_feature 
<222> (2688)...(2690) 
<223> FIX propeptide sequence


<220> 
<221> intron         
<222> (2691)...(4128)
<223> FIX partial intron 1


<220> 
<221> misc_feature 
<222> (4129)...(4179) 
<223> FIX propeptide sequence


<220> 
<221> misc_feature 
<222> (4180)...(5424) 
<223> FIX Zymogen


<220> 
<221> polyA_signal   
<222> (5539)...(5763)
<223> bovine growth hormone polyadenylation signal


<220> 
<221> repeat_region  
<222> (5877)...(6006)
<223> ITR

<400> 575
gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg 60
acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg 120
gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag 180
ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg 240
gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct 300
cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac 360
agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact 420
catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga 480
tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt 540
cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct 600
gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc 660
taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc 720
ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc 780
tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg 840
ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt 900
cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg 960
agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg 1020
gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt 1080
atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag 1140
gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt 1200
gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta 1260
ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt 1320
cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc 1380
cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca 1440
acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc 1500
cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg 1560
accatgatta cgccaagctt gcatgcctgc aggcagctgc gcgctcgctc gctcactgag 1620
gccgcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag 1680
agagggagtg gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtaaag 1740
atctgatatc atcgatcgcg atgcattaat taagcggccg aggctcagag gcacacagga 1800
gtttctgggc tcaccctgcc cccttccaac ccctcagttc ccatcctcca gcagctgttt 1860
gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc tactcatgtc cctaaaatgg 1920
gcaaacattg caagcagcaa acagcaaaca cacagccctc cctgcctgct gaccttggag 1980
ctggggcaga ggtcagagac ctctctgggc ccatgccacc tccaacatcc actcgacccc 2040
ttggaatttc ggtggagagg agcagaggtt gtcctggcgt ggtttaggta gtgtgagagg 2100
ggtacccggg gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga 2160
gggccagcta agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg 2220
gacacaggac gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg 2280
aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag 2340
ccagtggact tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca 2400
ccagcagcct cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc 2460
cctgtctcct cagcttcagg caccaccact gacctgggac agtgaatgat ccccctgatc 2520
tgcggcctcg acggtatcga taagcttgat atcgaattct agtcgtcgac cactttcaca 2580
atctgctagc aaaggttgcc accatgcagc gcgtgaacat gatcatggca gaatcaccag 2640
gcctcatcac catctgcctt ttaggatatc tactcagtgc tgaatgtaca ggtttgtttc 2700
cttttttaaa atacattgag tatgcttgcc ttttagatat agaaatatct gatgctgtct 2760
tcttcactaa attttgatta catgatttga cagcaatatt gaagagtcta acagccagca 2820
cgcaggttgg taagtactgg ttctttgtta gctaggtttt cttcttcttc atttttaaaa 2880
ctaaatagat cgacaatgct tatgatgcat ttatgtttaa taaacactgt tcagttcatg 2940
atttggtcat gtaattcctg ttagaaaaca ttcatctcct tggtttaaaa aaattaaaag 3000
tgggaaaaca aagaaatagc agaatatagt gaaaaaaaat aaccacatta tttttgtttg 3060
gacttaccac tttgaaatca aaatgggaaa caaaagcaca aacaatggcc ttatttacac 3120
aaaaagtctg attttaagat atatgacatt tcaaggtttc agaagtatgt aatgaggtgt 3180
gtctctaatt ttttaaatta tatatcttca atttaaagtt ttagttaaaa cataaagatt 3240
aacctttcat tagcaagctg ttagttatca ccaaagcttt tcatggatta ggaaaaaatc 3300
attttgtctc tatgtcaaac atcttggagt tgatatttgg ggaaacacaa tactcagttg 3360
agttccctag gggagaaaag caagcttaag aattgacata aagagtagga agttagctaa 3420
tgcaacatat atcactttgt tttttcacaa ctacagtgac tttatgtatt tcccagagga 3480
aggcatacag ggaagaaatt atcccatttg gacaaacagc atgttctcac aggaagcatt 3540
tatcacactt acttgtcaac tttctagaat caaatctagt agctgacagt accaggatca 3600
ggggtgccaa ccctaagcac ccccagaaag ctgactggcc ctgtggttcc cactccagac 3660
atgatgtcag ctgtgaaatc gacgtcgctg gaccataatt aggcttctgt tcttcaggag 3720
acatttgttc aaagtcattt gggcaaccat attctgaaaa cagcccagcc agggtgatgg 3780
atcactttgc aaagatcctc aatgagctat tttcaagtga tgacaaagtg tgaagttaac 3840
cgctcatttg agaactttct ttttcatcca aagtaaattc aaatatgatt agaaatctga 3900
ccttttatta ctggaattct cttgactaaa agtaaaattg aattttaatt cctaaatctc 3960
catgtgtata cagtactgtg ggaacatcac agattttggc tccatgccct aaagagaaat 4020
tggctttcag attatttgga ttaaaaacaa agactttctt aagagatgta aaattttcat 4080
gatgttttct tttttgctaa aactaaagaa ttattctttt acatttcagt ttttcttgat 4140
catgaaaatg ccaacaaaat tctgaatagg ccaaagaggt ataattcagg caaattggaa 4200
gagtttgtgc aagggaacct tgagagagaa tgtatggaag aaaagtgtag ttttgaagaa 4260
gcaagggaag tgtttgaaaa cactgaaaga acaactgaat tttggaagca gtatgttgat 4320
ggagatcagt gtgagtccaa tccatgttta aatggaggca gttgcaagga tgacattaat 4380
tcctatgaat gttggtgtcc ctttggattt gaaggaaaga actgtgaatt agatgtaaca 4440
tgtaacatta agaatggcag atgtgagcag ttttgtaaaa atagtgctga taacaaggtg 4500
gtttgctcct gtactgaggg atataggctt gcagaaaacc agaagtcctg tgaaccagca 4560
gtgccatttc catgtggaag agtgtctgtg tcacaaactt ctaagctcac cagagctgag 4620
actgtttttc ctgatgtgga ctatgtaaat tctactgaag ctgaaaccat tttggataac 4680
atcactcaaa gcacccaatc atttaatgac ttcactagag ttgtgggtgg agaagatgcc 4740
aagccaggtc aattcccttg gcaagttgtt ttgaatggta aagttgatgc attctgtgga 4800
ggctctattg ttaatgaaaa atggattgta actgctgccc actgtgttga aactggtgtt 4860
aaaattacag tggtggcagg ggaacataat attgaggaga cagaacatac agagcaaaag 4920
aggaatgtga ttagaattat tcctcaccac aactacaatg cagctattaa taagtacaac 4980
catgacattg cccttctgga actggatgaa cccttagtgc taaacagcta tgttacacct 5040
atttgcattg ctgacaagga atacaccaac atcttcctca aatttggatc tggctatgta 5100
agtggctggg gaagagtgtt ccacaaaggg tattcagctt tagttcttca gtaccttaga 5160
gtgccacttg ttgacagagc cacatgtctt gaatctacaa agttcagaat ctataacaac 5220
atgttctgtg ctggcttcca tgaaggaggt agagattcat gtcaaggaga tagtggggga 5280
ccccatgtta ctgaagtgga aggaaccagt ttcttaactg gaattattag ctggggtgaa 5340
gagtgtgcaa tgaaaggcaa atatggaata tataccaagg tatccagata tgtcaactgg 5400
attaaggaaa aaacaaagct cacttaatga aagatggatt tccaaggtta attcattgga 5460
attgaaaatt aacagccccc cccccccccc cctgcagatc tcgagccgaa ttcctgcagc 5520
ccgggggatc agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc 5580
ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg 5640
aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg 5700
acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta 5760
tggcttctga ggcggaaaga accagctggg gctcgagatc cactagacta gtgtacacgc 5820
gtgatatcag atctgttacg tagataagta gcatggcggg ttaatcatta actacaagga 5880
acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg 5940
gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc 6000
gcgcagctgc ctgcaggtcg actctagagg atccccgggt accgagctcg aattcactgg 6060
ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg 6120
cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt 6180
cccaacagtt gcgcagcctg aatggcgaat ggcgcctgat gcggtatttt ctccttacgc 6240
atctgtgcgg tatttcacac cgcatacgtc aaagcaacca tagtacgcgc cctgtagcgg 6300
cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc 6360
ttagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc 6420
cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc 6480
gaccccaaaa aacttgattt gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg 6540
gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact 6600
ggaacaacac tcaactctat ctcgggctat tcttttgatt tataagggat tttgccgatt 6660
tcggtctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa 6720
atattaacgt ttacaatttt atggtgcact ctcagtacaa tctgctctga tgccgcatag 6780
ttaagccagc cccgacaccc gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc 6840
ccggcatccg cttacagaca agctgtgacc gtctccggga gctgcatgtg tcagaggttt 6900
tcaccgtcat caccgaaacg cgcgagacga aagggcctcg tgatacgcct atttttatag 6960
gttaatgtca tgataataat ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg 7020
cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga 7080
caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat 7140
ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca 7200
gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc 7260
gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca 7320
atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg 7380
caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca 7440
gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata 7500
accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag 7560
ctaaccgctt ttttgcacaa catgg                                       7585



