                         SEQUENCE LISTING

<110>  NantKWest
 
<120>  CAR-NK-92 CELLS TARGETING EGFR SUPER-FAMILY RECEPTORS

<130>  104077.0007US4

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FC-epsilon-RI-gamma cytoplasmic domain

<400>  1

Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser 
1               5                   10                  15      


Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu 
            20                  25                  30          


Thr Leu Lys His Glu Lys Pro Pro Gln 
        35                  40      


<210>  2
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FC-epsilon-RI-gamma cytoplasmic domain

<400>  2
ctgaagatcc aggtccgaaa ggccgccatc accagctacg agaagtctga tggcgtgtac       60

accggcctga gcaccagaaa ccaggaaacc tacgagacac tgaagcacga gaagcccccc      120

cag                                                                    123


<210>  3
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 hinge

<400>  3

Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            20                  25                  30          


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Phe Trp 
        35                  40                  45              


Val Leu Val Val Val Gly 
    50                  


<210>  4
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain

<400>  4

Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
1               5                   10                  15      


Phe Trp Val Arg 
            20  


<210>  5
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 signaling domain

<400>  5

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  6
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB signaling domain

<400>  6

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  7
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta signaling domain

<400>  7

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  8
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta

<400>  8
gtgaagttta gcagatctgc cgacgcccct gcctaccagc agggacagaa tcagctgtac       60

aacgagctga acctgggcag acgggaagag tacgacgtgc tggataagag aagaggcaga      120

gatcccgaga tgggcggcaa gccccagaga agaaagaatc cccaggaagg cctgtataac      180

gaactgcaga aagacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagaga      240

agaagaggca agggccacga tggactgtac cagggactga gcacagccac caaggatacc      300

tacgatgccc tgcacatgca ggccctgcct ccaagataa                             339


<210>  9
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IL2

<400>  9

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  10
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human er-IL2

<400>  10

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Ser Glu Lys Asp Glu Leu 
145                 150                 155                 160 


<210>  11
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCgamma/CD16

<400>  11

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp 
225                 230                 235                 240 


Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                245                 250                 


<210>  12
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FCgamma/CD16 nt

<400>  12
atgtggcagc tgctgctgcc tacagctctc ctgctgctgg tgtccgccgg catgagaacc       60

gaggatctgc ctaaggccgt ggtgttcctg gaaccccagt ggtacagagt gctggaaaag      120

gacagcgtga ccctgaagtg ccagggcgcc tacagccccg aggacaatag cacccagtgg      180

ttccacaacg agagcctgat cagcagccag gccagcagct acttcatcga cgccgccacc      240

gtggacgaca gcggcgagta tagatgccag accaacctga gcaccctgag cgaccccgtg      300

cagctggaag tgcacatcgg atggctgctg ctgcaggccc ccagatgggt gttcaaagaa      360

gaggacccca tccacctgag atgccactct tggaagaaca ccgccctgca caaagtgacc      420

tacctgcaga acggcaaggg cagaaagtac ttccaccaca acagcgactt ctacatcccc      480

aaggccaccc tgaaggactc cggctcctac ttctgcagag gcctcgtggg cagcaagaac      540

gtgtccagcg agacagtgaa catcaccatc acccagggcc tggccgtgtc taccatcagc      600

agctttttcc cacccggcta ccaggtgtcc ttctgcctcg tgatggtgct gctgttcgcc      660

gtggacaccg gcctgtactt cagcgtgaaa acaaacatca gaagcagcac ccgggactgg      720

aaggaccaca agttcaagtg gcggaaggac ccccaggaca agtga                      765


<210>  13
<211>  1125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR7

<400>  13
gccaccatga aaagcgtgct ggtggtggct ctccttgtca ttttccaggt atgcctgtgt       60

caagatgagg tcacggacga ttacatcgga gacaacacca cagtggacta cactttgttc      120

gagtctttgt gctccaagaa ggacgtgcgg aactttaaag cctggttcct ccctatcatg      180

tactccatca tttgtttcgt gggcctactg ggcaatgggc tggtcgtgtt gacctatatc      240

tatttcaaga ggctcaagac catgaccgat acctacctgc tcaacctggc ggtggcagac      300

atcctcttcc tcctgaccct tcccttctgg gcctacagcg cggccaagtc ctgggtcttc      360

ggtgtccact tttgcaagct catctttgcc atctacaaga tgagcttctt cagtggcatg      420

ctcctacttc tttgcatcag cattgaccgc tacgtggcca tcgtccaggc tgtctcagct      480

caccgccacc gtgcccgcgt ccttctcatc agcaagctgt cctgtgtggg catctggata      540

ctagccacag tgctctccat cccagagctc ctgtacagtg acctccagag gagcagcagt      600

gagcaagcga tgcgatgctc tctcatcaca gagcatgtgg aggcctttat caccatccag      660

gtggcccaga tggtgatcgg ctttctggtc cccctgctgg ccatgagctt ctgttacctt      720

gtcatcatcc gcaccctgct ccaggcacgc aactttgagc gcaacaaggc catcaaggtg      780

atcatcgctg tggtcgtggt cttcatagtc ttccagctgc cctacaatgg ggtggtcctg      840

gcccagacgg tggccaactt caacatcacc agtagcacct gtgagctcag taagcaactc      900

aacatcgcct acgacgtcac ctacagcctg gcctgcgtcc gctgctgcgt caaccctttc      960

ttgtacgcct tcatcggcgt caagttccgc aacgatctct tcaagctctt caaggacctg     1020

ggctgcctca gccaggagca gctccggcag tggtcttcct gtcggcacat ccggcgctcc     1080

tccatgagtg tggaggccga gaccaccacc accttctccc catag                     1125


<210>  14
<211>  297
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCL19

<400>  14
atggccctgc tactggccct cagcctgctg gttctctgga cttccccagc cccaactctg       60

agtggcacca atgatgctga agactgctgc ctgtctgtga cccagaaacc catccctggg      120

tacatcgtga ggaacttcca ctaccttctc atcaaggatg gctgcagggt gcctgctgta      180

gtgttcacca cactgagggg ccgccagctc tgtgcacccc cagaccagcc ctgggtagaa      240

cgcatcatcc agagactgca gaggacctca gccaagatga agcgccgcag cagttaa         297


<210>  15
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCL21

<400>  15
atggctcagt cactggctct gagcctcctt atcctggttc tggcctttgg catccccagg       60

acccaaggca gtgatggagg ggctcaggac tgttgcctca agtacagcca aaggaagatt      120

cccgccaagg ttgtccgcag ctaccggaag caggaaccaa gcttaggctg ctccatccca      180

gctatcctgt tcttgccccg caagcgctct caggcagagc tatgtgcaga cccaaaggag      240

ctctgggtgc agcagctgat gcagcatctg gacaagacac catccccaca gaaaccagcc      300

cagggctgca ggaaggacag gggggcctcc aagactggca agaaaggaaa gggctccaaa      360

ggctgcaaga ggactgagcg gtcacagacc cctaaagggc catag                      405


<210>  16
<211>  1083
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CXCR2 nt

<400>  16
atggaagatt ttaacatgga gagtgacagc tttgaagatt tctggaaagg tgaagatctt       60

agtaattaca gttacagctc taccctgccc ccttttctac tagatgccgc cccatgtgaa      120

ccagaatccc tggaaatcaa caagtatttt gtggtcatta tctatgccct ggtattcctg      180

ctgagcctgc tgggaaactc cctcgtgatg ctggtcatct tatacagcag ggtcggccgc      240

tccgtcactg atgtctacct gctgaaccta gccttggccg acctactctt tgccctgacc      300

ttgcccatct gggccgcctc caaggtgaat ggctggattt ttggcacatt cctgtgcaag      360

gtggtctcac tcctgaagga agtcaacttc tatagtggca tcctgctact ggcctgcatc      420

agtgtggacc gttacctggc cattgtccat gccacacgca cactgaccca gaagcgctac      480

ttggtcaaat tcatatgtct cagcatctgg ggtctgtcct tgctcctggc cctgcctgtc      540

ttacttttcc gaaggaccgt ctactcatcc aatgttagcc cagcctgcta tgaggacatg      600

ggcaacaata cagcaaactg gcggatgctg ttacggatcc tgccccagtc ctttggcttc      660

atcgtgccac tgctgatcat gctgttctgc tacggattca ccctgcgtac gctgtttaag      720

gcccacatgg ggcagaagca ccgggccatg cgggtcatct ttgctgtcgt cctcatcttc      780

ctgctctgct ggctgcccta caacctggtc ctgctggcag acaccctcat gaggacccag      840

gtgatccagg agacctgtga gcgccgcaat cacatcgacc gggctctgga tgccaccgag      900

attctgggca tccttcacag ctgcctcaac cccctcatct acgccttcat tggccagaag      960

tttcgccatg gactcctcaa gattctagct atacatggct tgatcagcaa ggactccctg     1020

cccaaagaca gcaggccttc ctttgttggc tcttcttcag ggcacacttc cactactctc     1080

taa                                                                   1083


<210>  17
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR2 aa

<400>  17

Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      


Gly Glu Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Thr Leu Pro Pro Phe 
            20                  25                  30          


Leu Leu Asp Ala Ala Pro Cys Glu Pro Glu Ser Leu Glu Ile Asn Lys 
        35                  40                  45              


Tyr Phe Val Val Ile Ile Tyr Ala Leu Val Phe Leu Leu Ser Leu Leu 
    50                  55                  60                  


Gly Asn Ser Leu Val Met Leu Val Ile Leu Tyr Ser Arg Val Gly Arg 
65                  70                  75                  80  


Ser Val Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ala Asp Leu Leu 
                85                  90                  95      


Phe Ala Leu Thr Leu Pro Ile Trp Ala Ala Ser Lys Val Asn Gly Trp 
            100                 105                 110         


Ile Phe Gly Thr Phe Leu Cys Lys Val Val Ser Leu Leu Lys Glu Val 
        115                 120                 125             


Asn Phe Tyr Ser Gly Ile Leu Leu Leu Ala Cys Ile Ser Val Asp Arg 
    130                 135                 140                 


Tyr Leu Ala Ile Val His Ala Thr Arg Thr Leu Thr Gln Lys Arg Tyr 
145                 150                 155                 160 


Leu Val Lys Phe Ile Cys Leu Ser Ile Trp Gly Leu Ser Leu Leu Leu 
                165                 170                 175     


Ala Leu Pro Val Leu Leu Phe Arg Arg Thr Val Tyr Ser Ser Asn Val 
            180                 185                 190         


Ser Pro Ala Cys Tyr Glu Asp Met Gly Asn Asn Thr Ala Asn Trp Arg 
        195                 200                 205             


Met Leu Leu Arg Ile Leu Pro Gln Ser Phe Gly Phe Ile Val Pro Leu 
    210                 215                 220                 


Leu Ile Met Leu Phe Cys Tyr Gly Phe Thr Leu Arg Thr Leu Phe Lys 
225                 230                 235                 240 


Ala His Met Gly Gln Lys His Arg Ala Met Arg Val Ile Phe Ala Val 
                245                 250                 255     


Val Leu Ile Phe Leu Leu Cys Trp Leu Pro Tyr Asn Leu Val Leu Leu 
            260                 265                 270         


Ala Asp Thr Leu Met Arg Thr Gln Val Ile Gln Glu Thr Cys Glu Arg 
        275                 280                 285             


Arg Asn His Ile Asp Arg Ala Leu Asp Ala Thr Glu Ile Leu Gly Ile 
    290                 295                 300                 


Leu His Ser Cys Leu Asn Pro Leu Ile Tyr Ala Phe Ile Gly Gln Lys 
305                 310                 315                 320 


Phe Arg His Gly Leu Leu Lys Ile Leu Ala Ile His Gly Leu Ile Ser 
                325                 330                 335     


Lys Asp Ser Leu Pro Lys Asp Ser Arg Pro Ser Phe Val Gly Ser Ser 
            340                 345                 350         


Ser Gly His Thr Ser Thr Thr Leu 
        355                 360 


<210>  18
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CXCL4 nt

<400>  18
atgtccctgc tcccacgccg cgcccctccg gtcagcatga ggctcctggc ggccgcgctg       60

ctcctgctgc tgctggcgct gtacaccgcg cgtgtggacg ggtccaaatg caagtgctcc      120

cggaagggac ccaagatccg ctacagcgac gtgaagaagc tggaaatgaa gccaaagtac      180

ccgcactgcg aggagaagat ggttatcatc accaccaaga gcgtgtccag gtaccgaggt      240

caggagcact gcctgcaccc caagctgcag agcaccaagc gcttcatcaa gtggtacaac      300

gcctggaacg agaagcgcag ggtctacgaa gaatag                                336


<210>  19
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL4 aa

<400>  19

Met Ser Leu Leu Pro Arg Arg Ala Pro Pro Val Ser Met Arg Leu Leu 
1               5                   10                  15      


Ala Ala Ala Leu Leu Leu Leu Leu Leu Ala Leu Tyr Thr Ala Arg Val 
            20                  25                  30          


Asp Gly Ser Lys Cys Lys Cys Ser Arg Lys Gly Pro Lys Ile Arg Tyr 
        35                  40                  45              


Ser Asp Val Lys Lys Leu Glu Met Lys Pro Lys Tyr Pro His Cys Glu 
    50                  55                  60                  


Glu Lys Met Val Ile Ile Thr Thr Lys Ser Val Ser Arg Tyr Arg Gly 
65                  70                  75                  80  


Gln Glu His Cys Leu His Pro Lys Leu Gln Ser Thr Lys Arg Phe Ile 
                85                  90                  95      


Lys Trp Tyr Asn Ala Trp Asn Glu Lys Arg Arg Val Tyr Glu Glu 
            100                 105                 110     


<210>  20
<211>  1119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD62L nt

<400>  20
atgatatttc catggaaatg tcagagcacc cagagggact tatggaacat cttcaagttg       60

tgggggtgga caatgctctg ttgtgatttc ctggcacatc atggaaccga ctgctggact      120

taccattatt ctgaaaaacc catgaactgg caaagggcta gaagattctg ccgagacaat      180

tacacagatt tagttgccat acaaaacaag gcggaaattg agtatctgga gaagactctg      240

cctttcagtc gttcttacta ctggatagga atccggaaga taggaggaat atggacgtgg      300

gtgggaacca acaaatctct tactgaagaa gcagagaact ggggagatgg tgagcccaac      360

aacaagaaga acaaggagga ctgcgtggag atctatatca agagaaacaa agatgcaggc      420

aaatggaacg atgacgcctg ccacaaacta aaggcagccc tctgttacac agcttcttgc      480

cagccctggt catgcagtgg ccatggagaa tgtgtagaaa tcatcaataa ttacacctgc      540

aactgtgatg tggggtacta tgggccccag tgtcagtttg tgattcagtg tgagcctttg      600

gaggccccag agctgggtac catggactgt actcaccctt tgggaaactt cagcttcagc      660

tcacagtgtg ccttcagctg ctctgaagga acaaacttaa ctgggattga agaaaccacc      720

tgtggaccat ttggaaactg gtcatctcca gaaccaacct gtcaagtgat tcagtgtgag      780

cctctatcag caccagattt ggggatcatg aactgtagcc atcccctggc cagcttcagc      840

tttacctctg catgtacctt catctgctca gaaggaactg agttaattgg gaagaagaaa      900

accatttgtg aatcatctgg aatctggtca aatcctagtc caatatgtca aaaattggac      960

aaaagtttct caatgattaa ggagggtgat tataaccccc tcttcattcc agtggcagtc     1020

atggttactg cattctctgg gttggcattt atcatttggc tggcaaggag attaaaaaaa     1080

ggcaagaaat ccaagagaag tatgaatgac ccatattaa                            1119


<210>  21
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD62L aa

<400>  21

Met Ile Phe Pro Trp Lys Cys Gln Ser Thr Gln Arg Asp Leu Trp Asn 
1               5                   10                  15      


Ile Phe Lys Leu Trp Gly Trp Thr Met Leu Cys Cys Asp Phe Leu Ala 
            20                  25                  30          


His His Gly Thr Asp Cys Trp Thr Tyr His Tyr Ser Glu Lys Pro Met 
        35                  40                  45              


Asn Trp Gln Arg Ala Arg Arg Phe Cys Arg Asp Asn Tyr Thr Asp Leu 
    50                  55                  60                  


Val Ala Ile Gln Asn Lys Ala Glu Ile Glu Tyr Leu Glu Lys Thr Leu 
65                  70                  75                  80  


Pro Phe Ser Arg Ser Tyr Tyr Trp Ile Gly Ile Arg Lys Ile Gly Gly 
                85                  90                  95      


Ile Trp Thr Trp Val Gly Thr Asn Lys Ser Leu Thr Glu Glu Ala Glu 
            100                 105                 110         


Asn Trp Gly Asp Gly Glu Pro Asn Asn Lys Lys Asn Lys Glu Asp Cys 
        115                 120                 125             


Val Glu Ile Tyr Ile Lys Arg Asn Lys Asp Ala Gly Lys Trp Asn Asp 
    130                 135                 140                 


Asp Ala Cys His Lys Leu Lys Ala Ala Leu Cys Tyr Thr Ala Ser Cys 
145                 150                 155                 160 


Gln Pro Trp Ser Cys Ser Gly His Gly Glu Cys Val Glu Ile Ile Asn 
                165                 170                 175     


Asn Tyr Thr Cys Asn Cys Asp Val Gly Tyr Tyr Gly Pro Gln Cys Gln 
            180                 185                 190         


Phe Val Ile Gln Cys Glu Pro Leu Glu Ala Pro Glu Leu Gly Thr Met 
        195                 200                 205             


Asp Cys Thr His Pro Leu Gly Asn Phe Ser Phe Ser Ser Gln Cys Ala 
    210                 215                 220                 


Phe Ser Cys Ser Glu Gly Thr Asn Leu Thr Gly Ile Glu Glu Thr Thr 
225                 230                 235                 240 


Cys Gly Pro Phe Gly Asn Trp Ser Ser Pro Glu Pro Thr Cys Gln Val 
                245                 250                 255     


Ile Gln Cys Glu Pro Leu Ser Ala Pro Asp Leu Gly Ile Met Asn Cys 
            260                 265                 270         


Ser His Pro Leu Ala Ser Phe Ser Phe Thr Ser Ala Cys Thr Phe Ile 
        275                 280                 285             


Cys Ser Glu Gly Thr Glu Leu Ile Gly Lys Lys Lys Thr Ile Cys Glu 
    290                 295                 300                 


Ser Ser Gly Ile Trp Ser Asn Pro Ser Pro Ile Cys Gln Lys Leu Asp 
305                 310                 315                 320 


Lys Ser Phe Ser Met Ile Lys Glu Gly Asp Tyr Asn Pro Leu Phe Ile 
                325                 330                 335     


Pro Val Ala Val Met Val Thr Ala Phe Ser Gly Leu Ala Phe Ile Ile 
            340                 345                 350         


Trp Leu Ala Arg Arg Leu Lys Lys Gly Lys Lys Ser Lys Arg Ser Met 
        355                 360                 365             


Asn Asp Pro Tyr 
    370         


<210>  22
<211>  300
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL8 nt

<400>  22
atgacttcca agctggccgt ggctctcttg gcagccttcc tgatttctgc agctctgtgt       60

gaaggtgcag ttttgccaag gagtgctaaa gaacttagat gtcagtgcat aaagacatac      120

tccaaacctt tccaccccaa atttatcaaa gaactgagag tgattgagag tggaccacac      180

tgcgccaaca cagaaattat tgtaaagctt tctgatggaa gagagctctg tctggacccc      240

aaggaaaact gggtgcagag ggttgtggag aagtttttga agagggctga gaattcataa      300


<210>  23
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL8 aa

<400>  23

Met Thr Ser Lys Leu Ala Val Ala Leu Leu Ala Ala Phe Leu Ile Ser 
1               5                   10                  15      


Ala Ala Leu Cys Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu 
            20                  25                  30          


Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe 
        35                  40                  45              


Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr 
    50                  55                  60                  


Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro 
65                  70                  75                  80  


Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala 
                85                  90                  95      


Glu Asn Ser 
            


<210>  24
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CXCL1 nt

<400>  24
atggcccgcg ctgctctctc cgccgccccc agcaatcccc ggctcctgcg agtggcactg       60

ctgctcctgc tcctggtagc cgctggccgg cgcgcagcag gagcgtccgt ggccactgaa      120

ctgcgctgcc agtgcttgca gaccctgcag ggaattcacc ccaagaacat ccaaagtgtg      180

aacgtgaagt cccccggacc ccactgcgcc caaaccgaag tcatagccac actcaagaat      240

gggcggaaag cttgcctcaa tcctgcatcc cccatagtta agaaaatcat cgaaaagatg      300

ctgaacagtg acaaatccaa ctga                                             324


<210>  25
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL1 aa

<400>  25

Met Ala Arg Ala Ala Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Gly Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Ser Val Ala Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 
        35                  40                  45              


Leu Gln Gly Ile His Pro Lys Asn Ile Gln Ser Val Asn Val Lys Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 
65                  70                  75                  80  


Gly Arg Lys Ala Cys Leu Asn Pro Ala Ser Pro Ile Val Lys Lys Ile 
                85                  90                  95      


Ile Glu Lys Met Leu Asn Ser Asp Lys Ser Asn 
            100                 105         


<210>  26
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-12 p35 nt

<400>  26
atgtggcccc ctgggtcagc ctcccagcca ccgccctcac ctgccgcggc cacaggtctg       60

catccagcgg ctcgccctgt gtccctgcag tgccggctca gcatgtgtcc agcgcgcagc      120

ctcctccttg tggctaccct ggtcctcctg gaccacctca gtttggccag aaacctcccc      180

gtggccactc cagacccagg aatgttccca tgccttcacc actcccaaaa cctgctgagg      240

gccgtcagca acatgctcca gaaggccaga caaactctag aattttaccc ttgcacttct      300

gaagagattg atcatgaaga tatcacaaaa gataaaacca gcacagtgga ggcctgttta      360

ccattggaat taaccaagaa tgagagttgc ctaaattcca gagagacctc tttcataact      420

aatgggagtt gcctggcctc cagaaagacc tcttttatga tggccctgtg ccttagtagt      480

atttatgaag acttgaagat gtaccaggtg gagttcaaga ccatgaatgc aaagcttctg      540

atggatccta agaggcagat ctttctagat caaaacatgc tggcagttat tgatgagctg      600

atgcaggccc tgaatttcaa cagtgagact gtgccacaaa aatcctccct tgaagaaccg      660

gatttttata aaactaaaat caagctctgc atacttcttc atgctttcag aattcgggca      720

gtgactattg atagagtgat gagctatctg aatgcttcct aa                         762


<210>  27
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-12 p35 aa

<400>  27

Met Trp Pro Pro Gly Ser Ala Ser Gln Pro Pro Pro Ser Pro Ala Ala 
1               5                   10                  15      


Ala Thr Gly Leu His Pro Ala Ala Arg Pro Val Ser Leu Gln Cys Arg 
            20                  25                  30          


Leu Ser Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val 
        35                  40                  45              


Leu Leu Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro 
    50                  55                  60                  


Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg 
65                  70                  75                  80  


Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr 
                85                  90                  95      


Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys 
            100                 105                 110         


Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu 
        115                 120                 125             


Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys 
    130                 135                 140                 


Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser 
145                 150                 155                 160 


Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn 
                165                 170                 175     


Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn 
            180                 185                 190         


Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser 
        195                 200                 205             


Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys 
    210                 215                 220                 


Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala 
225                 230                 235                 240 


Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
                245                 250             


<210>  28
<211>  987
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-12 p40 nt

<400>  28
atgtgtcacc agcagttggt catctcttgg ttttccctgg tttttctggc atctcccctc       60

gtggccatat gggaactgaa gaaagatgtt tatgtcgtag aattggattg gtatccggat      120

gcccctggag aaatggtggt cctcacctgt gacacccctg aagaagatgg tatcacctgg      180

accttggacc agagcagtga ggtcttaggc tctggcaaaa ccctgaccat ccaagtcaaa      240

gagtttggag atgctggcca gtacacctgt cacaaaggag gcgaggttct aagccattcg      300

ctcctgctgc ttcacaaaaa ggaagatgga atttggtcca ctgatatttt aaaggaccag      360

aaagaaccca aaaataagac ctttctaaga tgcgaggcca agaattattc tggacgtttc      420

acctgctggt ggctgacgac aatcagtact gatttgacat tcagtgtcaa aagcagcaga      480

ggctcttctg acccccaagg ggtgacgtgc ggagctgcta cactctctgc agagagagtc      540

agaggggaca acaaggagta tgagtactca gtggagtgcc aggaggacag tgcctgccca      600

gctgctgagg agagtctgcc cattgaggtc atggtggatg ccgttcacaa gctcaagtat      660

gaaaactaca ccagcagctt cttcatcagg gacatcatca aacctgaccc acccaagaac      720

ttgcagctga agccattaaa gaattctcgg caggtggagg tcagctggga gtaccctgac      780

acctggagta ctccacattc ctacttctcc ctgacattct gcgttcaggt ccagggcaag      840

agcaagagag aaaagaaaga tagagtcttc acggacaaga cctcagccac ggtcatctgc      900

cgcaaaaatg ccagcattag cgtgcgggcc caggaccgct actatagctc atcttggagc      960

gaatgggcat ctgtgccctg cagttag                                          987


<210>  29
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-12 p40 aa

<400>  29

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210>  30
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HER2 CAR (Fce)

<400>  30
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccg acatccagat gacccagagc cccagcagcc tgagcgccag cgtgggcgac      120

agagtgacca tcacctgcag agccagccag gacgtgaaca ccgccgtggc ctggtaccag      180

cagaagcccg gcaaggcccc caagctgctg atctacagcg ccagcttcct gtacagcggc      240

gtgcccagca gattcagcgg cagcagaagc ggcaccgact tcaccctgac catcagcagc      300

ctgcagcccg aggacttcgc cacctactac tgccagcagc actacaccac cccccccacc      360

ttcggccagg gcaccaaggt ggagatcaag tcctcagggg gcgggggaag tggtgggggc      420

ggcagcggcg gagggggctc aggaggaggc ggatcaggcg gatcagaggt gcagctggtg      480

gagagcggcg gcggcctggt gcagcccggc ggcagcctga gactgagctg cgccgccagc      540

ggcttcaaca tcaaggacac ctacatccac tgggtgagac aggcccccgg caagggcctg      600

gagtgggtgg ccagaatcta ccccaccaac ggctacacca gatacgccga cagcgtgaag      660

ggcagattca ccatcagcgc cgacaccagc aagaacaccg cctacctgca gatgaacagc      720

ctgagagccg aggacaccgc cgtgtactac tgcagcagat ggggcggcga cggcttctac      780

gccatggact actggggcca gggcaccctg gtgaccgtga gcagcgcggc cgcgctgagc      840

aacagcatca tgtacttcag ccacttcgtg cctgtgttcc tgcctgccaa gcctacaaca      900

acaccagccc ctagacctcc aacccctgcc cctacaattg cctctcagcc tctgtctctg      960

aggcccgaag cttgtagacc tgctgctggc ggagctgtgc acaccagagg actggatttc     1020

gcctgctttt gggtgctggt ggtcgtgggc ggagtgctgg cttgttattc tctgctggtc     1080

accgtggcct tcatcatctt ttgggtccga ctgaagatcc aggtccgaaa ggccgccatc     1140

accagctacg agaagtctga tggcgtgtac accggcctga gcaccagaaa ccaggaaacc     1200

tacgagacac tgaagcacga gaagcccccc cag                                  1233


<210>  31
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-12 single chain p40_p35 aa

<400>  31

Met Gly His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Val Pro Gly Val Gly Val Pro Gly 
                325                 330                 335     


Val Gly Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe 
            340                 345                 350         


Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met 
        355                 360                 365             


Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu 
    370                 375                 380                 


Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu 
385                 390                 395                 400 


Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser 
                405                 410                 415     


Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys 
            420                 425                 430         


Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Ser 
        435                 440                 445             


Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met 
    450                 455                 460                 


Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile 
465                 470                 475                 480 


Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln 
                485                 490                 495     


Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu 
            500                 505                 510         


Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg 
        515                 520                 525             


Val Met Ser Tyr Leu Asn Ala Ser 
    530                 535     


<210>  32
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-12 single chain p40_p35 nt

<400>  32
atgggtcacc agcagttggt catctcttgg ttttccctgg tttttctggc atctcccctc       60

gtggccatat gggaactgaa gaaagatgtt tatgtcgtag aattggattg gtatccggat      120

gcccctggag aaatggtggt cctcacctgt gacacccctg aagaagatgg tatcacctgg      180

accttggacc agagcagtga ggtcttaggc tctggcaaaa ccctgaccat ccaagtcaaa      240

gagtttggag atgctggcca gtacacctgt cacaaaggag gcgaggttct aagccattcg      300

ctcctgctgc ttcacaaaaa ggaagatgga atttggtcca ctgatatttt aaaggaccag      360

aaagaaccca aaaataagac ctttctaaga tgcgaggcca agaattattc tggacgtttc      420

acctgctggt ggctgacgac aatcagtact gatttgacat tcagtgtcaa aagcagcaga      480

ggctcttctg acccccaagg ggtgacgtgc ggagctgcta cactctctgc agagagagtc      540

agaggggaca acaaggagta tgagtactca gtggagtgcc aggaggacag tgcctgccca      600

gctgctgagg agagtctgcc cattgaggtc atggtggatg ccgttcacaa gctcaagtat      660

gaaaactaca ccagcagctt cttcatcagg gacatcatca aacctgaccc acccaagaac      720

ttgcagctga agccattaaa gaattctcgg caggtggagg tcagctggga gtaccctgac      780

acctggagta ctccacattc ctacttctcc ctgacattct gcgttcaggt ccagggcaag      840

agcaagagag aaaagaaaga tagagtcttc acggacaaga cctcagccac ggtcatctgc      900

cgcaaaaatg ccagcattag cgtgcgggcc caggaccgct actatagctc atcttggagc      960

gaatgggcat ctgtgccctg cagtgttcct ggagtagggg tacctggggt gggcgccaga     1020

aacctccccg tggccactcc agacccagga atgttcccat gccttcacca ctcccaaaac     1080

ctgctgaggg ccgtcagcaa catgctccag aaggccagac aaactctaga attttaccct     1140

tgcacttctg aagagattga tcatgaagat atcacaaaag ataaaaccag cacagtggag     1200

gcctgtttac cattggaatt aaccaagaat gagagttgcc taaattccag agagacctct     1260

ttcataacta atgggagttg cctggcctcc agaaagacct cttttatgat ggccctgtgc     1320

cttagtagta tttatgaaga ctcgaagatg taccaggtgg agttcaagac catgaatgca     1380

aagcttctga tggatcctaa gaggcagatc tttctagatc aaaacatgct ggcagttatt     1440

gatgagctga tgcaggccct gaatttcaac agtgagactg tgccacaaaa atcctccctt     1500

gaagaaccgg atttttataa aactaaaatc aagctctgca tacttcttca tgctttcaga     1560

attcgggcag tgactattga tagagtgatg agctatctga atgcttccta a              1611


<210>  33
<211>  1215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EGFR CAR (Fce)

<400>  33
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccg atattcttct tactcaatct cccgttattt tgtcagtatc cccaggtgag      120

cgagtcagct tctcttgtcg agcgtcacaa tccattggca ccaacataca ttggtaccaa      180

cagcgcacca acgggtctcc ccggctcttg attaagtacg catcagaaag tatttctggg      240

atacccagta ggttctcagg gagcgggagt ggcactgact ttaccctgtc cataaacagc      300

gttgagtctg aggacatcgc ggactactat tgtcagcaga acaacaattg gccgaccacg      360

tttggtgcgg gaacaaaact tgaactcaaa ggcggcggag gaagcggagg cggaggatct      420

gggggcggag gctctggcgg agggggatct caggtgcagc tcaaacagtc aggacctggc      480

ctcgttcagc caagccaatc actgagtata acgtgcacgg tgagcggctt tagcctgaca      540

aactatggtg tccactgggt ccgccaatct cctggaaaag gcttggagtg gctcggtgtt      600

atctggtccg gtggtaacac agactacaac acgccattca ccagtcgcct tagtattaac      660

aaggacaact ccaagtctca ggttttcttt aaaatgaact ctctgcagtc taatgatacc      720

gcaatttact actgtgcgag ggcactcacg tactatgact atgagttcgc gtattggggc      780

caagggactc tcgttactgt ctcagcggcg gccgcgctga gcaacagcat catgtacttc      840

agccacttcg tgcctgtgtt cctgcctgcc aagcctacaa caacaccagc ccctagacct      900

ccaacccctg cccctacaat tgcctctcag cctctgtctc tgaggcccga agcttgtaga      960

cctgctgctg gcggagctgt gcacaccaga ggactggatt tcgcctgctt ttgggtgctg     1020

gtggtcgtgg gcggagtgct ggcttgttat tctctgctgg tcaccgtggc cttcatcatc     1080

ttttgggtcc gactgaagat ccaggtccga aaggccgcca tcaccagcta cgagaagtct     1140

gatggcgtgt acaccggcct gagcaccaga aaccaggaaa cctacgagac actgaagcac     1200

gagaagcccc cccag                                                      1215


<210>  34
<211>  477
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TGF-beta receptor II extracellular domain nt

<400>  34
atgggtcggg ggctgctcag gggcctgtgg ccgctgcaca tcgtcctgtg gacgcgtatc       60

gccagcacga tcccaccgca cgttcagaag tcggttaata acgacatgat agtcactgac      120

aacaacggtg cagtcaagtt tccacaactg tgtaaatttt gtgatgtgag attttccacc      180

tgtgacaacc agaaatcctg catgagcaac tgcagcatca cctccatctg tgagaagcca      240

caggaagtct gtgtggctgt atggagaaag aatgacgaga acataacact agagacagtt      300

tgccatgacc ccaagctccc ctaccatgac tttattctgg aagatgctgc ttctccaaag      360

tgcattatga aggaaaaaaa aaagcctggt gagactttct tcatgtgttc ctgtagctct      420

gatgagtgca atgacaacat catcttctca gaagaatata acaccagcaa tcctgac         477


<210>  35
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGF-beta receptor II extracellular domain aa

<400>  35

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp 
145                 150                 155                 


<210>  36
<211>  933
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TGF-beta trap nt

<400>  36
atgggtcggg ggctgctcag gggcctgtgg ccgctgcaca tcgtcctgtg gacgcgtatc       60

gccagcacga tcccaccgca cgttcagaag tcggttaata acgacatgat agtcactgac      120

aacaacggtg cagtcaagtt tccacaactg tgtaaatttt gtgatgtgag attttccacc      180

tgtgacaacc agaaatcctg catgagcaac tgcagcatca cctccatctg tgagaagcca      240

caggaagtct gtgtggctgt atggagaaag aatgacgaga acataacact agagacagtt      300

tgccatgacc ccaagctccc ctaccatgac tttattctgg aagatgctgc ttctccaaag      360

tgcattatga aggaaaaaaa aaagcctggt gagactttct tcatgtgttc ctgtagctct      420

gatgagtgca atgacaacat catcttctca gaagaatata acaccagcaa tcctgacgga      480

ggtggaggaa gtggaggagg tggaagtggt ggtggaggta gtacgatccc accgcacgtt      540

cagaagtcgg ttaataacga catgatagtc actgacaaca acggtgcagt caagtttcca      600

caactgtgta aattttgtga tgtgagattt tccacctgtg acaaccagaa atcctgcatg      660

agcaactgca gcatcacctc catctgtgag aagccacagg aagtctgtgt ggctgtatgg      720

agaaagaatg acgagaacat aacactagag acagtttgcc atgaccccaa gctcccctac      780

catgacttta ttctggaaga tgctgcttct ccaaagtgca ttatgaagga aaaaaaaaag      840

cctggtgaga ctttcttcat gtgttcctgt agctctgatg agtgcaatga caacatcatc      900

ttctcagaag aatataacac cagcaatcct gac                                   933


<210>  37
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGF-beta trap aa

<400>  37

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Ile 
                165                 170                 175     


Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp 
            180                 185                 190         


Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val 
        195                 200                 205             


Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser 
    210                 215                 220                 


Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp 
225                 230                 235                 240 


Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro 
                245                 250                 255     


Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys 
            260                 265                 270         


Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys 
        275                 280                 285             


Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu 
    290                 295                 300                 


Tyr Asn Thr Ser Asn Pro Asp 
305                 310     


<210>  38
<211>  510
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  erIL-15 nt

<400>  38
atgcgcatca gcaagcccca cctgcgcagc atcagcatcc agtgctacct gtgcctgctg       60

ctgaacagcc acttcctgac cgaggccggc atccacgtgt tcatcctggg ctgcttcagc      120

gccggcctgc ccaagaccga ggccaactgg gtgaacgtga tcagcgacct gaagaagatc      180

gaggacctga tccagagcat gcacatcgac gccaccctgt acaccgagag cgacgtgcac      240

cccagctgca aggtgaccgc catgaagtgc ttcctgctgg agctgcaggt gatcagcctg      300

gagagcggcg acgccagcat ccacgacacc gtggagaacc tgatcatcct ggccaacaac      360

agcctgagca gcaacggcaa cgtgaccgag agcggctgca aggagtgcga ggagctggag      420

gagaagaaca tcaaggagtt cctgcagagc ttcgtgcaca tcgtgcagat gttcatcaac      480

accagcggct ccgagaagga cgagctgtaa                                       510


<210>  39
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  erIL-15 aa

<400>  39

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser Gly Ser Glu Lys Asp Glu Leu 
                165                 


<210>  40
<211>  807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized EGFR scFv - DNA sequence

<400>  40
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccg atattcttct tactcaatct cccgttattt tgtcagtatc cccaggtgag      120

cgagtcagct tctcttgtcg agcgtcacaa tccattggca ccaacataca ttggtaccaa      180

cagcgcacca acgggtctcc ccggctcttg attaagtacg catcagaaag tatttctggg      240

atacccagta ggttctcagg gagcgggagt ggcactgact ttaccctgtc cataaacagc      300

gttgagtctg aggacatcgc ggactactat tgtcagcaga acaacaattg gccgaccacg      360

tttggtgcgg gaacaaaact tgaactcaaa ggcggcggag gaagcggagg cggaggatct      420

gggggcggag gctctggcgg agggggatct caggtgcagc tcaaacagtc aggacctggc      480

ctcgttcagc caagccaatc actgagtata acgtgcacgg tgagcggctt tagcctgaca      540

aactatggtg tccactgggt ccgccaatct cctggaaaag gcttggagtg gctcggtgtt      600

atctggtccg gtggtaacac agactacaac acgccattca ccagtcgcct tagtattaac      660

aaggacaact ccaagtctca ggttttcttt aaaatgaact ctctgcagtc taatgatacc      720

gcaatttact actgtgcgag ggcactcacg tactatgact atgagttcgc gtattggggc      780

caagggactc tcgttactgt ctcagcg                                          807


<210>  41
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR scFv - Protein sequence

<400>  41

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ala Gln Pro Ala Asp Ile Leu Leu Thr Gln Ser Pro Val 
            20                  25                  30          


Ile Leu Ser Val Ser Pro Gly Glu Arg Val Ser Phe Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Ser Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Arg Thr Asn 
    50                  55                  60                  


Gly Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly 
65                  70                  75                  80  


Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Ser Ile Asn Ser Val Glu Ser Glu Asp Ile Ala Asp Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly Ala Gly Thr Lys Leu Glu 
        115                 120                 125             


Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys Gln Ser Gly Pro Gly 
145                 150                 155                 160 


Leu Val Gln Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly 
                165                 170                 175     


Phe Ser Leu Thr Asn Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp 
        195                 200                 205             


Tyr Asn Thr Pro Phe Thr Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser 
    210                 215                 220                 


Lys Ser Gln Val Phe Phe Lys Met Asn Ser Leu Gln Ser Asn Asp Thr 
225                 230                 235                 240 


Ala Ile Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe 
                245                 250                 255     


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
            260                 265                 


<210>  42
<211>  825
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized HER2/neu scFv - DNA sequence

<400>  42
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccg acatccagat gacccagagc cccagcagcc tgagcgccag cgtgggcgac      120

agagtgacca tcacctgcag agccagccag gacgtgaaca ccgccgtggc ctggtaccag      180

cagaagcccg gcaaggcccc caagctgctg atctacagcg ccagcttcct gtacagcggc      240

gtgcccagca gattcagcgg cagcagaagc ggcaccgact tcaccctgac catcagcagc      300

ctgcagcccg aggacttcgc cacctactac tgccagcagc actacaccac cccccccacc      360

ttcggccagg gcaccaaggt ggagatcaag tcctcagggg gcgggggaag tggtgggggc      420

ggcagcggcg gagggggctc aggaggaggc ggatcaggcg gatcagaggt gcagctggtg      480

gagagcggcg gcggcctggt gcagcccggc ggcagcctga gactgagctg cgccgccagc      540

ggcttcaaca tcaaggacac ctacatccac tgggtgagac aggcccccgg caagggcctg      600

gagtgggtgg ccagaatcta ccccaccaac ggctacacca gatacgccga cagcgtgaag      660

ggcagattca ccatcagcgc cgacaccagc aagaacaccg cctacctgca gatgaacagc      720

ctgagagccg aggacaccgc cgtgtactac tgcagcagat ggggcggcga cggcttctac      780

gccatggact actggggcca gggcaccctg gtgaccgtga gcagc                      825


<210>  43
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2/neu scFv - Protein sequence

<400>  43

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ala Gln Pro Ala Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro 
        195                 200                 205             


Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly 
                245                 250                 255     


Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            260                 265                 270         


Val Ser Ser 
        275 


