                         SEQUENCE LISTING

<110>  MedImmune Limited
 
<120>  Anti-avb8 integrin antibodies for use in treating kidney disease

<130>  AVB8-201-US-PSP

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HCDR1

<400>  1

Arg Tyr Trp Met Ser 
1               5   


<210>  2
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  2

Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Ser Ser Leu 
1               5                   10                  15  


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3

<400>  3

Leu Ile Thr Thr Glu Asp Tyr 
1               5           


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1

<400>  4

Lys Ala Ser Gln Asp Ile Asn Ser Tyr Leu Ser 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2

<400>  5

Tyr Ala Asn Arg Leu Val Asp 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  6

Leu Gln Tyr Asp Glu Phe Pro Tyr Thr 
1               5                   


<210>  7
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH region

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Val Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Ser Ser Leu 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Leu Ile Thr Thr Glu Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  8
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL region

<400>  8

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1

<400>  9

Arg Ser Trp Ile Ser 
1               5   


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1

<400>  10

Lys Ala Ser Gln Asp Ile Asn Lys Tyr Leu Ser 
1               5                   10      


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  11

Leu Gln Tyr Asp Val Phe Pro Tyr Thr 
1               5                   


<210>  12
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH region

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Val Phe Ser Arg Ser 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Ser Ser Leu 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Leu Ile Thr Thr Glu Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  13
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL region

<400>  13

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Val Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  14
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH region

<400>  14
gaggtgcagc tggtggaaag cggcggagga ctggtgcagc ctggcggcag cctgagactg       60

agctgcgccg tgtccggctt cgtgttcagc cggagctgga tcagctgggt ccgccaggcc      120

ccagggaagg gcctggaatg gatcggcgag atcaaccccg acagcagcac catcaactac      180

accagcagcc tgaaggaccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc catcctcatc      300

accaccgagg actactgggg ccagggcacc accgtgaccg tgtcctct                   348


<210>  15
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL region

<400>  15
gacatccagc tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacatgca aggccagcca ggacatcaac aagtacctga gctggttcca gcagaagccc      120

ggcaaggccc ccaagagcct gatctactac gccaaccggc tggtggacgg cgtgcccagc      180

agattttctg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgcctgcag tacgacgtgt tcccctacac cttcggcgga      300

ggcaccaagg tggaaatcaa g                                                321


<210>  16
<211>  769
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Cys Gly Ser Ala Leu Ala Phe Phe Thr Ala Ala Phe Val Cys Leu 
1               5                   10                  15      


Gln Asn Asp Arg Arg Gly Pro Ala Ser Phe Leu Trp Ala Ala Trp Val 
            20                  25                  30          


Phe Ser Leu Val Leu Gly Leu Gly Gln Gly Glu Asp Asn Arg Cys Ala 
        35                  40                  45              


Ser Ser Asn Ala Ala Ser Cys Ala Arg Cys Leu Ala Leu Gly Pro Glu 
    50                  55                  60                  


Cys Gly Trp Cys Val Gln Glu Asp Phe Ile Ser Gly Gly Ser Arg Ser 
65                  70                  75                  80  


Glu Arg Cys Asp Ile Val Ser Asn Leu Ile Ser Lys Gly Cys Ser Val 
                85                  90                  95      


Asp Ser Ile Glu Tyr Pro Ser Val His Val Ile Ile Pro Thr Glu Asn 
            100                 105                 110         


Glu Ile Asn Thr Gln Val Thr Pro Gly Glu Val Ser Ile Gln Leu Arg 
        115                 120                 125             


Pro Gly Ala Glu Ala Asn Phe Met Leu Lys Val His Pro Leu Lys Lys 
    130                 135                 140                 


Tyr Pro Val Asp Leu Tyr Tyr Leu Val Asp Val Ser Ala Ser Met His 
145                 150                 155                 160 


Asn Asn Ile Glu Lys Leu Asn Ser Val Gly Asn Asp Leu Ser Arg Lys 
                165                 170                 175     


Met Ala Phe Phe Ser Arg Asp Phe Arg Leu Gly Phe Gly Ser Tyr Val 
            180                 185                 190         


Asp Lys Thr Val Ser Pro Tyr Ile Ser Ile His Pro Glu Arg Ile His 
        195                 200                 205             


Asn Gln Cys Ser Asp Tyr Asn Leu Asp Cys Met Pro Pro His Gly Tyr 
    210                 215                 220                 


Ile His Val Leu Ser Leu Thr Glu Asn Ile Thr Glu Phe Glu Lys Ala 
225                 230                 235                 240 


Val His Arg Gln Lys Ile Ser Gly Asn Ile Asp Thr Pro Glu Gly Gly 
                245                 250                 255     


Phe Asp Ala Met Leu Gln Ala Ala Val Cys Glu Ser His Ile Gly Trp 
            260                 265                 270         


Arg Lys Glu Ala Lys Arg Leu Leu Leu Val Met Thr Asp Gln Thr Ser 
        275                 280                 285             


His Leu Ala Leu Asp Ser Lys Leu Ala Gly Ile Val Val Pro Asn Asp 
    290                 295                 300                 


Gly Asn Cys His Leu Lys Asn Asn Val Tyr Val Lys Ser Thr Thr Met 
305                 310                 315                 320 


Glu His Pro Ser Leu Gly Gln Leu Ser Glu Lys Leu Ile Asp Asn Asn 
                325                 330                 335     


Ile Asn Val Ile Phe Ala Val Gln Gly Lys Gln Phe His Trp Tyr Lys 
            340                 345                 350         


Asp Leu Leu Pro Leu Leu Pro Gly Thr Ile Ala Gly Glu Ile Glu Ser 
        355                 360                 365             


Lys Ala Ala Asn Leu Asn Asn Leu Val Val Glu Ala Tyr Gln Lys Leu 
    370                 375                 380                 


Ile Ser Glu Val Lys Val Gln Val Glu Asn Gln Val Gln Gly Ile Tyr 
385                 390                 395                 400 


Phe Asn Ile Thr Ala Ile Cys Pro Asp Gly Ser Arg Lys Pro Gly Met 
                405                 410                 415     


Glu Gly Cys Arg Asn Val Thr Ser Asn Asp Glu Val Leu Phe Asn Val 
            420                 425                 430         


Thr Val Thr Met Lys Lys Cys Asp Val Thr Gly Gly Lys Asn Tyr Ala 
        435                 440                 445             


Ile Ile Lys Pro Ile Gly Phe Asn Glu Thr Ala Lys Ile His Ile His 
    450                 455                 460                 


Arg Asn Cys Ser Cys Gln Cys Glu Asp Asn Arg Gly Pro Lys Gly Lys 
465                 470                 475                 480 


Cys Val Asp Glu Thr Phe Leu Asp Ser Lys Cys Phe Gln Cys Asp Glu 
                485                 490                 495     


Asn Lys Cys His Phe Asp Glu Asp Gln Phe Ser Ser Glu Ser Cys Lys 
            500                 505                 510         


Ser His Lys Asp Gln Pro Val Cys Ser Gly Arg Gly Val Cys Val Cys 
        515                 520                 525             


Gly Lys Cys Ser Cys His Lys Ile Lys Leu Gly Lys Val Tyr Gly Lys 
    530                 535                 540                 


Tyr Cys Glu Lys Asp Asp Phe Ser Cys Pro Tyr His His Gly Asn Leu 
545                 550                 555                 560 


Cys Ala Gly His Gly Glu Cys Glu Ala Gly Arg Cys Gln Cys Phe Ser 
                565                 570                 575     


Gly Trp Glu Gly Asp Arg Cys Gln Cys Pro Ser Ala Ala Ala Gln His 
            580                 585                 590         


Cys Val Asn Ser Lys Gly Gln Val Cys Ser Gly Arg Gly Thr Cys Val 
        595                 600                 605             


Cys Gly Arg Cys Glu Cys Thr Asp Pro Arg Ser Ile Gly Arg Phe Cys 
    610                 615                 620                 


Glu His Cys Pro Thr Cys Tyr Thr Ala Cys Lys Glu Asn Trp Asn Cys 
625                 630                 635                 640 


Met Gln Cys Leu His Pro His Asn Leu Ser Gln Ala Ile Leu Asp Gln 
                645                 650                 655     


Cys Lys Thr Ser Cys Ala Leu Met Glu Gln Gln His Tyr Val Asp Gln 
            660                 665                 670         


Thr Ser Glu Cys Phe Ser Ser Pro Ser Tyr Leu Arg Ile Phe Phe Ile 
        675                 680                 685             


Ile Phe Ile Val Thr Phe Leu Ile Gly Leu Leu Lys Val Leu Ile Ile 
    690                 695                 700                 


Arg Gln Val Ile Leu Gln Trp Asn Ser Asn Lys Ile Lys Ser Ser Ser 
705                 710                 715                 720 


Asp Tyr Arg Val Ser Ala Ser Lys Lys Asp Lys Leu Ile Leu Gln Ser 
                725                 730                 735     


Val Cys Thr Arg Ala Val Thr Tyr Arg Arg Glu Lys Pro Glu Glu Ile 
            740                 745                 750         


Lys Met Asp Ile Ser Lys Leu Asn Ala His Glu Thr Phe Arg Cys Asn 
        755                 760                 765             


Phe 
    


<210>  17
<211>  8787
<212>  DNA
<213>  Homo sapiens

<400>  17
ggcgggtgct tctagggcgc tcccagagcc gcctccccct gttgctggca tcccgagctt       60

cctcccttgc cagccaggac gctgccgact tgtctttgcc cgctgctccg cagacggggc      120

tgcaaagctg caactaatgg tgttggcctc cctgcccacc tgtggaagca actgcgctga      180

ttgatgcgcc acagactttt ttcccctcga cctcgccggc gtcccctccc acagatccag      240

catcacccag tgaatgtaca ttagggtggt ttccccccca gcttcgggct ttgtttgggt      300

ttgattgtgt ttggctcttc gctaagctga tttatgcagc agaagcccca ccggctggag      360

agaaacaaaa gctcttttct ttgtcccgga gcaggctgcg gagcccttgc agagccctct      420

ctccagtcgc cgccggggcc cttggccgtc gaaggaggtg cttctcgcgg agaccgcggg      480

acccgccgtg ccgagccggg agggccgcag gggccctgag atgccgagcg gtgcccgggc      540

ccgcttacct gcaccgcttg ctccgagccg cggggtccgc ctgctaggcc tgcggaaaac      600

gtcctagcga cactcggccc gcgggccccg aggtgcgccc gggaggcgcg agcccgcgtc      660

cggaaggcag tcaggcggcg ggcgcggggc gggctgtttt gcattatgtg cggctcggcc      720

ctggcttttt ttaccgctgc atttgtctgc ctgcaaaacg accggcgagg tcccgcctcg      780

ttcctctggg cagcctgggt gttttcactt gttcttggac tgggccaagg tgaagacaat      840

agatgtgcat cttcaaatgc agcatcctgt gccaggtgcc ttgcgctggg tccagaatgt      900

ggatggtgtg ttcaagagga tttcatttca ggtggatcaa gaagtgaacg ttgtgatatt      960

gtttccaatt taataagcaa aggctgctca gttgattcaa tagaataccc atctgtgcat     1020

gttataatac ccactgaaaa tgaaattaat acccaggtga caccaggaga agtgtctatc     1080

cagctgcgtc caggagccga agctaatttt atgctgaaag ttcatcctct gaagaaatat     1140

cctgtggatc tttattatct tgttgatgtc tcagcatcaa tgcacaataa tatagaaaaa     1200

ttaaattccg ttggaaacga tttatctaga aaaatggcat ttttctcccg tgactttcgt     1260

cttggatttg gctcatacgt tgataaaaca gtttcaccat acattagcat ccaccccgaa     1320

aggattcata atcaatgcag tgactacaat ttagactgca tgcctcccca tggatacatc     1380

catgtgctgt ctttgacaga gaacatcact gagtttgaga aagcagttca tagacagaag     1440

atctctggaa acatagatac accagaagga ggttttgacg ccatgcttca ggcagctgtc     1500

tgtgaaagtc atatcggatg gcgaaaagag gctaaaagat tgctgctggt gatgacagat     1560

cagacgtctc atctcgctct tgatagcaaa ttggcaggca tagtggtgcc caatgacgga     1620

aactgtcatc tgaaaaacaa cgtctatgtc aaatcgacaa ccatggaaca cccctcacta     1680

ggccaacttt cagagaaatt aatagacaac aacattaatg tcatctttgc agttcaagga     1740

aaacaatttc attggtataa ggatcttcta cccctcttgc caggcaccat tgctggtgaa     1800

atagaatcaa aggctgcaaa cctcaataat ttggtagtgg aagcctatca gaagctcatt     1860

tcagaagtga aagttcaggt ggaaaaccag gtacaaggca tctattttaa cattaccgcc     1920

atctgtccag atgggtccag aaagccaggc atggaaggat gcagaaacgt gacgagcaat     1980

gatgaagttc ttttcaatgt aacagttaca atgaaaaaat gtgatgtcac aggaggaaaa     2040

aactatgcaa taatcaaacc tattggtttt aatgaaaccg ctaaaattca tatacacaga     2100

aactgcagct gtcagtgtga ggacaacaga ggacctaaag gaaagtgtgt agatgaaact     2160

tttctagatt ccaagtgttt ccagtgtgat gagaataaat gtcattttga tgaagatcag     2220

ttttcttctg agagttgcaa gtcacacaag gatcagcctg tttgcagtgg tcgaggagtt     2280

tgtgtttgtg ggaaatgttc atgtcacaaa attaagcttg gaaaagtgta tggaaaatac     2340

tgtgaaaagg atgacttttc ttgtccatat caccatggaa atctgtgtgc tgggcatgga     2400

gagtgtgaag caggcagatg ccaatgcttc agtggctggg aaggtgatcg atgccagtgc     2460

ccttcagcag cagcccagca ctgtgtcaat tcaaagggcc aagtgtgcag tggaagaggc     2520

acgtgtgtgt gtggaaggtg tgagtgcacc gatcccagga gcatcggccg cttctgtgaa     2580

cactgcccca cctgttatac agcctgcaag gaaaactgga attgtatgca atgccttcac     2640

cctcacaatt tgtctcaggc tatacttgat cagtgcaaaa cctcatgtgc tctcatggaa     2700

caacagcatt atgtcgacca aacttcagaa tgtttctcca gcccaagcta cttgagaata     2760

tttttcatca ttttcatagt tacattcttg attgggttgc ttaaagtcct gatcattaga     2820

caggtgatac tacaatggaa tagtaataaa attaagtcct catcagatta cagagtgtca     2880

gcctcaaaaa aggataagtt gattctgcaa agtgtttgca caagagcagt cacctaccga     2940

cgtgagaagc ctgaagaaat aaaaatggat atcagcaaat taaatgctca tgaaactttc     3000

aggtgcaact tctaaaaaaa gatttttaaa cacttaatgg gaaactggaa ttgttaataa     3060

ttgctcctaa agattataat tttaaaagtc acaggaggag acaaattgct cacggtcatg     3120

ccagttgctg gttgtacact cgaacgaaga ctgacaagta tcctcatcat gatgtgactc     3180

acatagctgc tgactttttc agagaaaaat gtgtcttact actgtttgag actagtgtcg     3240

ttgtagcact ttactgtaat atataactta tttagatcag catagaatgt agatcctctg     3300

aagagcactg attacacttt acaggtacct gttatcccta cgcttcccag agagaacaat     3360

gctgtgagag agtttagcat tgtgtcacta caagggtaca gtaatccctg cactggacat     3420

gtgaggaaaa aaataatctg gcaagtatat tctaaggttg ccaaacactt caacagttgg     3480

tggttgaata gacaagaaca gctagatgaa taaatgattc gtgtttcact ctttcaagag     3540

gtgaacagat acaaccttaa tcttaaaaga ttattgcttt ttaaagtgtg tagttttatg     3600

catgtgtgtt tatggtttgc ttatttttgc aagatggata ctaattccag cattctctcc     3660

tctttgcctt tatgttttgt tttctttttt acaggataag tttatgtatg tcacagatga     3720

ctggattaat taagtgctaa gttactactg ccataaaaaa ctaataatac aatgtcactt     3780

tatcagaata ctagttttaa aagctgaatg ttaatagggg acactgtaaa gtatcatcaa     3840

aacctgaata gcttcattgt gcacaagtgt ggagttttgt atcctcttac ctggtaaact     3900

gaagggattg tttggccatt tcatttatct tatcattaat tcacaagata gttagaaatt     3960

ctgcctcaag caaagtacca cattttgaat gttttcttag attttgattg caagtagata     4020

tcagcatttt ttaaatgaaa agctatatta tcttctccct tcaaggcagc ctaaggatgt     4080

tctttcccag aatcactcca acccttcttg ccagaattca taaaagtaca aaattggaga     4140

atagatgata tcttagaaat aagctttttt tttttttttt tttttttttg agacggagtt     4200

tcactcttgt cacccaggct gaagtgcaat ggcgcaatta gggttcactg caacctctgc     4260

ctcccgggtt caagcagttc tcctgcctca gcctcctgag tagctgggat tacaggcatc     4320

caccaccgtg cccagctaat ttttgtattt ttagtagaga cggggttttg ccatgttgga     4380

caggttgatc tcaaactcct gacctcaggt gatctaccct cctcggcctc ccagagtgtt     4440

gggattacag gcatgagcca ccatgccagg ctgctaattc tcctttttag tgagttaggg     4500

aactgagcct cagaaaactt aaacgatttc tcagaaaaca ctcaagtgat aaagtggcca     4560

cattggaaag gagtttttat cttctcattg tcaggccagt gttcattgca caatatcatg     4620

ctacctcttg aatctttaaa atattcaatt ggcaaatgtt tttcaatgtg atttactcat     4680

gtcttaagtg tatgaggaaa gttcaaagca aaatagaaag gaataattca aactgaattg     4740

tccataatca gcttccagtc tttcatgcta atcagcttct taagagactg aagtatggca     4800

tacctacagg ggaattcctt cgcaccatag cctgtatgaa cagtgttccc tggagttctc     4860

cagtgctcag cttgagacct tgatacacgg gccatgagcc ctgtcttccc caatggaaat     4920

ttatttacac ttaccttatc cctatggact tagtctgatt ttattggcta ggagtctaac     4980

agtcctgtgt ggatatacag ttttgcccat gacaacaaag gaatctatcc gaaatatctt     5040

tttttttata ataaacttcc aagatttgct gtcttccagc acttgagtta aagtactaga     5100

tactgcattt tgatgaagac taaccccatc tcatattcta ccctaaagag aactgaaaaa     5160

cctataataa gttgttctgg agccaataaa cacagcagct ctgttagatg tcctctacag     5220

ccaagcactt tcaatgctaa cttgaactgc atttccttcc tcaaatgaga gattgacata     5280

attcagtact gtgagtcact tgtataagaa acctttgatc actaaaaata atgtaaaaat     5340

tgggtttagt agcctaatac acataacgtt cttcttaaaa aggaaaatgg atggatgcct     5400

gacaaccctc caaaagaaaa aagtgtaaga tagccattaa gatgatgaca atttttgaaa     5460

tgaacattat gatatttatg aacaataaac aaatttccgt atggaatgaa ttatccaaaa     5520

agagtataac aaaatgaaat ccttaaaaat ccagagttta tatttttttt ataccctcac     5580

ttgtttgcac taactttata gtggaccaag gctgttacca taggaaggga caaacttcct     5640

tgtaggcaac tcagtgttag acgatgattg tggttatgct tgcaaagtct tgtgcttatc     5700

ttttttgttt ttacttaaaa agctaatttt taaagattgt agggcttgta ttttacttga     5760

ataattgata tcttcctgtg taatgatttg tgagatgaga attaatattt gactagttag     5820

aattaattaa atggtaaggg aacacagggt actcttaggt taaataatgt atgcaaatag     5880

agtctatttt caactaatat ggccacagga gccttttgag attcattgat attaaacaca     5940

attaatgaaa ttttaaattg ttaacagaat tgagaacttg aacaacactt ttagtactgc     6000

agcatttttg tgccctaaag tatgtaatga tttataaatg tgccatacat acactacaac     6060

ataacatttg ctttgttatg cattttattt ctctggggac accattgcac tgcagtgcac     6120

acgtatttat aaacatttgt tatatttttg gaaacttgct aatatttatt aagtcataga     6180

cttttctgga ggacttaaaa attcactaaa aatctgatta tgtcttaaat gttcagttta     6240

tctttggttt attaaaataa aaaaaaaatc taagattaaa cacagtagat atctctggag     6300

gcaattttcc aaaactcaac attaaaattt gtggatgcat gagatgcaat ccttcaaaga     6360

atgaatctga aatatatttt taatatttac ttaatatcca ctgaagatat ctttatgcaa     6420

gacaagagtc agccatcaga cactgaaata tattatgata gattatgaag aattttctct     6480

gtagaattat attcttcctg gaacctggta gagtagatta gactcaaagg ctttttcttc     6540

cttttcttac tcctgttttt tccactcact cttcccaaga gatttcctaa agcttcaagc     6600

ttaataagcc taatagtgaa aaataactga atttaatggt ataatgaagt tcttcatttc     6660

cagacatctt taattgatct taaagctcat ttgagtcttt gcccctgaac aaagacagac     6720

ccattaaaat ctaagaattc taaattttca caactgtttg agcttctttt cattttgaag     6780

gatttggaat atatatgttt tcataaaagt atcaagtgaa atatagttac atgggagctc     6840

aatcatgtgc agattgcatt ctgttatgtt gactcaatat ttaatttaca actatcctta     6900

tttatattga cctcaagaac tccattttat gcaatgcaga ccactgagat atagctaaca     6960

ttctttcaaa taattttcct tttcttttat aattcctcta tagcaaattt ttatgtataa     7020

ctgattatac atatccatat ttatatttca ttgattccaa gacatcactt tttcaattta     7080

acatctctga aattgtgaca tttcttgcaa ctgttggcac ttcagatgca gtgtttaaaa     7140

ttatgcttga ataaatatta cactaatcca actttaccta aatgtttatg catctaggca     7200

aattttgttt tcttataaag atttgagagc ccatttatga caaaatatga aggcgaaatt     7260

taaggacaac tgagtcacgc acaactcaac atggagccta actgattatc agctcagatc     7320

ccgcatatct tgagtttaca aaagctcttt caggtcccca tttatacttt acgtgagtgc     7380

gaatgatttc agcaaaccct aacttaacta acaagaatgg gtaggtatgt ctacgtttca     7440

ttaacaaatt tttattattt ttattctatt atatgagatc cttttatatt atcatctcac     7500

ttttaaacaa aattaactgg aaaaatatta catggaactg tcatagttag gttttgcagc     7560

atcttacatg tcttgtatca atggcaggag aaaaatatga taaaaacaat cagtgctgtg     7620

aaaaacaact ttcttctaga gtcctcttac tttttattct tctttatcat ttgtgggttt     7680

ttcccccttg gctctgatca ctttaacttc aagcttatgt aacgactgtt ataaaactgc     7740

atatttaaat tatttgaatt atatgaaata attgttcagc tatctgggca gctgttaatg     7800

taaacctgag agtaataaca ctactctttt atctacctgg aatacttttc tgcataaaat     7860

ttatctttgt aagctaactc tattaatcag gtttcttcta gcctctgcaa cctacttcag     7920

ttagaattgt ctaatactgc tctattaatc aggtttctag cctctacaac ctacttcagt     7980

taaaattgtc taatacagca atatttaaaa aaaaaacact gcaattgtca aggatggaaa     8040

atgtgtgatt tgtgtaaaca atttttacca actttacatt ttcctacaga taaatgtgaa     8100

attttgataa gaagtctacg caatgacaag tatggtacat aaattttatt aagaatattg     8160

agtataaagt actttaattc taaattataa gaaaatatac atttgcacat attaatatag     8220

aaattcattt tgtgtatatt taacatagct tttaaactat tttacattag ctacttcatt     8280

atggtttctt gaacttctga aaaaaattag aaatgtatta aacttatcag taacataaaa     8340

acttattttg tttcacctaa cgaatactgc gtttgtaaaa ataaatttaa tatagaatat     8400

atttttaaat taaatatttg aatataaaat agctctaaga aagaagcaaa ttatcactga     8460

acatatttct tattatttct ggctttgaat tatacgtaac ttaaattgtc ttaaatgata     8520

cagaatattg gagaatatga tactttcaca taatatacta tgaacctgtt catataactc     8580

tgattgacta ctaacttctg ttttatgtat ttattaaaga gctgacactg tagtttgtgg     8640

tgagatgttt atttttctaa cagagcttat aacagttagg acaaggcatt taattaatgc     8700

atcattctgt ttagtagtag gtgttaatca atatgaaatt ctctgtttta aaataaaaat     8760

gtaaaaatct aagaataaaa aaaaaaa                                         8787


<210>  18
<211>  1048
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Phe Pro Pro Arg Arg Arg Leu Arg Leu Gly Pro Arg Gly Leu 
1               5                   10                  15      


Pro Leu Leu Leu Ser Gly Leu Leu Leu Pro Leu Cys Arg Ala Phe Asn 
            20                  25                  30          


Leu Asp Val Asp Ser Pro Ala Glu Tyr Ser Gly Pro Glu Gly Ser Tyr 
        35                  40                  45              


Phe Gly Phe Ala Val Asp Phe Phe Val Pro Ser Ala Ser Ser Arg Met 
    50                  55                  60                  


Phe Leu Leu Val Gly Ala Pro Lys Ala Asn Thr Thr Gln Pro Gly Ile 
65                  70                  75                  80  


Val Glu Gly Gly Gln Val Leu Lys Cys Asp Trp Ser Ser Thr Arg Arg 
                85                  90                  95      


Cys Gln Pro Ile Glu Phe Asp Ala Thr Gly Asn Arg Asp Tyr Ala Lys 
            100                 105                 110         


Asp Asp Pro Leu Glu Phe Lys Ser His Gln Trp Phe Gly Ala Ser Val 
        115                 120                 125             


Arg Ser Lys Gln Asp Lys Ile Leu Ala Cys Ala Pro Leu Tyr His Trp 
    130                 135                 140                 


Arg Thr Glu Met Lys Gln Glu Arg Glu Pro Val Gly Thr Cys Phe Leu 
145                 150                 155                 160 


Gln Asp Gly Thr Lys Thr Val Glu Tyr Ala Pro Cys Arg Ser Gln Asp 
                165                 170                 175     


Ile Asp Ala Asp Gly Gln Gly Phe Cys Gln Gly Gly Phe Ser Ile Asp 
            180                 185                 190         


Phe Thr Lys Ala Asp Arg Val Leu Leu Gly Gly Pro Gly Ser Phe Tyr 
        195                 200                 205             


Trp Gln Gly Gln Leu Ile Ser Asp Gln Val Ala Glu Ile Val Ser Lys 
    210                 215                 220                 


Tyr Asp Pro Asn Val Tyr Ser Ile Lys Tyr Asn Asn Gln Leu Ala Thr 
225                 230                 235                 240 


Arg Thr Ala Gln Ala Ile Phe Asp Asp Ser Tyr Leu Gly Tyr Ser Val 
                245                 250                 255     


Ala Val Gly Asp Phe Asn Gly Asp Gly Ile Asp Asp Phe Val Ser Gly 
            260                 265                 270         


Val Pro Arg Ala Ala Arg Thr Leu Gly Met Val Tyr Ile Tyr Asp Gly 
        275                 280                 285             


Lys Asn Met Ser Ser Leu Tyr Asn Phe Thr Gly Glu Gln Met Ala Ala 
    290                 295                 300                 


Tyr Phe Gly Phe Ser Val Ala Ala Thr Asp Ile Asn Gly Asp Asp Tyr 
305                 310                 315                 320 


Ala Asp Val Phe Ile Gly Ala Pro Leu Phe Met Asp Arg Gly Ser Asp 
                325                 330                 335     


Gly Lys Leu Gln Glu Val Gly Gln Val Ser Val Ser Leu Gln Arg Ala 
            340                 345                 350         


Ser Gly Asp Phe Gln Thr Thr Lys Leu Asn Gly Phe Glu Val Phe Ala 
        355                 360                 365             


Arg Phe Gly Ser Ala Ile Ala Pro Leu Gly Asp Leu Asp Gln Asp Gly 
    370                 375                 380                 


Phe Asn Asp Ile Ala Ile Ala Ala Pro Tyr Gly Gly Glu Asp Lys Lys 
385                 390                 395                 400 


Gly Ile Val Tyr Ile Phe Asn Gly Arg Ser Thr Gly Leu Asn Ala Val 
                405                 410                 415     


Pro Ser Gln Ile Leu Glu Gly Gln Trp Ala Ala Arg Ser Met Pro Pro 
            420                 425                 430         


Ser Phe Gly Tyr Ser Met Lys Gly Ala Thr Asp Ile Asp Lys Asn Gly 
        435                 440                 445             


Tyr Pro Asp Leu Ile Val Gly Ala Phe Gly Val Asp Arg Ala Ile Leu 
    450                 455                 460                 


Tyr Arg Ala Arg Pro Val Ile Thr Val Asn Ala Gly Leu Glu Val Tyr 
465                 470                 475                 480 


Pro Ser Ile Leu Asn Gln Asp Asn Lys Thr Cys Ser Leu Pro Gly Thr 
                485                 490                 495     


Ala Leu Lys Val Ser Cys Phe Asn Val Arg Phe Cys Leu Lys Ala Asp 
            500                 505                 510         


Gly Lys Gly Val Leu Pro Arg Lys Leu Asn Phe Gln Val Glu Leu Leu 
        515                 520                 525             


Leu Asp Lys Leu Lys Gln Lys Gly Ala Ile Arg Arg Ala Leu Phe Leu 
    530                 535                 540                 


Tyr Ser Arg Ser Pro Ser His Ser Lys Asn Met Thr Ile Ser Arg Gly 
545                 550                 555                 560 


Gly Leu Met Gln Cys Glu Glu Leu Ile Ala Tyr Leu Arg Asp Glu Ser 
                565                 570                 575     


Glu Phe Arg Asp Lys Leu Thr Pro Ile Thr Ile Phe Met Glu Tyr Arg 
            580                 585                 590         


Leu Asp Tyr Arg Thr Ala Ala Asp Thr Thr Gly Leu Gln Pro Ile Leu 
        595                 600                 605             


Asn Gln Phe Thr Pro Ala Asn Ile Ser Arg Gln Ala His Ile Leu Leu 
    610                 615                 620                 


Asp Cys Gly Glu Asp Asn Val Cys Lys Pro Lys Leu Glu Val Ser Val 
625                 630                 635                 640 


Asp Ser Asp Gln Lys Lys Ile Tyr Ile Gly Asp Asp Asn Pro Leu Thr 
                645                 650                 655     


Leu Ile Val Lys Ala Gln Asn Gln Gly Glu Gly Ala Tyr Glu Ala Glu 
            660                 665                 670         


Leu Ile Val Ser Ile Pro Leu Gln Ala Asp Phe Ile Gly Val Val Arg 
        675                 680                 685             


Asn Asn Glu Ala Leu Ala Arg Leu Ser Cys Ala Phe Lys Thr Glu Asn 
    690                 695                 700                 


Gln Thr Arg Gln Val Val Cys Asp Leu Gly Asn Pro Met Lys Ala Gly 
705                 710                 715                 720 


Thr Gln Leu Leu Ala Gly Leu Arg Phe Ser Val His Gln Gln Ser Glu 
                725                 730                 735     


Met Asp Thr Ser Val Lys Phe Asp Leu Gln Ile Gln Ser Ser Asn Leu 
            740                 745                 750         


Phe Asp Lys Val Ser Pro Val Val Ser His Lys Val Asp Leu Ala Val 
        755                 760                 765             


Leu Ala Ala Val Glu Ile Arg Gly Val Ser Ser Pro Asp His Val Phe 
    770                 775                 780                 


Leu Pro Ile Pro Asn Trp Glu His Lys Glu Asn Pro Glu Thr Glu Glu 
785                 790                 795                 800 


Asp Val Gly Pro Val Val Gln His Ile Tyr Glu Leu Arg Asn Asn Gly 
                805                 810                 815     


Pro Ser Ser Phe Ser Lys Ala Met Leu His Leu Gln Trp Pro Tyr Lys 
            820                 825                 830         


Tyr Asn Asn Asn Thr Leu Leu Tyr Ile Leu His Tyr Asp Ile Asp Gly 
        835                 840                 845             


Pro Met Asn Cys Thr Ser Asp Met Glu Ile Asn Pro Leu Arg Ile Lys 
    850                 855                 860                 


Ile Ser Ser Leu Gln Thr Thr Glu Lys Asn Asp Thr Val Ala Gly Gln 
865                 870                 875                 880 


Gly Glu Arg Asp His Leu Ile Thr Lys Arg Asp Leu Ala Leu Ser Glu 
                885                 890                 895     


Gly Asp Ile His Thr Leu Gly Cys Gly Val Ala Gln Cys Leu Lys Ile 
            900                 905                 910         


Val Cys Gln Val Gly Arg Leu Asp Arg Gly Lys Ser Ala Ile Leu Tyr 
        915                 920                 925             


Val Lys Ser Leu Leu Trp Thr Glu Thr Phe Met Asn Lys Glu Asn Gln 
    930                 935                 940                 


Asn His Ser Tyr Ser Leu Lys Ser Ser Ala Ser Phe Asn Val Ile Glu 
945                 950                 955                 960 


Phe Pro Tyr Lys Asn Leu Pro Ile Glu Asp Ile Thr Asn Ser Thr Leu 
                965                 970                 975     


Val Thr Thr Asn Val Thr Trp Gly Ile Gln Pro Ala Pro Met Pro Val 
            980                 985                 990         


Pro Val Trp Val Ile Ile Leu Ala  Val Leu Ala Gly Leu  Leu Leu Leu 
        995                 1000                 1005             


Ala Val  Leu Val Phe Val Met  Tyr Arg Met Gly Phe  Phe Lys Arg 
    1010                 1015                 1020             


Val Arg  Pro Pro Gln Glu Glu  Gln Glu Arg Glu Gln  Leu Gln Pro 
    1025                 1030                 1035             


His Glu  Asn Gly Glu Gly Asn  Ser Glu Thr 
    1040                 1045             


<210>  19
<211>  3147
<212>  DNA
<213>  Homo sapiens

<400>  19
atggcttttc cgccgcggcg acggctgcgc ctcggtcccc gcggcctccc gcttcttctc       60

tcgggactcc tgctacctct gtgccgcgcc ttcaacctag acgtggacag tcctgccgag      120

tactctggcc ccgagggaag ttacttcggc ttcgccgtgg atttcttcgt gcccagcgcg      180

tcttcccgga tgtttcttct cgtgggagct cccaaagcaa acaccaccca gcctgggatt      240

gtggaaggag ggcaggtcct caaatgtgac tggtcttcta cccgccggtg ccagccaatt      300

gaatttgatg caacaggcaa tagagattat gccaaggatg atccattgga atttaagtcc      360

catcagtggt ttggagcatc tgtgaggtcg aaacaggata aaattttggc ctgtgcccca      420

ttgtaccatt ggagaactga gatgaaacag gagcgagagc ctgttggaac atgctttctt      480

caagatggaa caaagactgt tgagtatgct ccatgtagat cacaagatat tgatgctgat      540

ggacagggat tttgtcaagg aggattcagc attgatttta ctaaagctga cagagtactt      600

cttggtggtc ctggtagctt ttattggcaa ggtcagctta tttcggatca agtggcagaa      660

atcgtatcta aatacgaccc caatgtttac agcatcaagt ataataacca attagcaact      720

cggactgcac aagctatttt tgatgacagc tatttgggtt attctgtggc tgtcggagat      780

ttcaatggtg atggcataga tgactttgtt tcaggagttc caagagcagc aaggactttg      840

ggaatggttt atatttatga tgggaagaac atgtcctcct tatacaattt tactggcgag      900

cagatggctg catatttcgg attttctgta gctgccactg acattaatgg agatgattat      960

gcagatgtgt ttattggagc acctctcttc atggatcgtg gctctgatgg caaactccaa     1020

gaggtggggc aggtctcagt gtctctacag agagcttcag gagacttcca gacgacaaag     1080

ctgaatggat ttgaggtctt tgcacggttt ggcagtgcca tagctccttt gggagatctg     1140

gaccaggatg gtttcaatga tattgcaatt gctgctccat atgggggtga agataaaaaa     1200

ggaattgttt atatcttcaa tggaagatca acaggcttga acgcagtccc atctcaaatc     1260

cttgaagggc agtgggctgc tcgaagcatg ccaccaagct ttggctattc aatgaaagga     1320

gccacagata tagacaaaaa tggatatcca gacttaattg taggagcttt tggtgtagat     1380

cgagctatct tatacagggc cagaccagtt atcactgtaa atgctggtct tgaagtgtac     1440

cctagcattt taaatcaaga caataaaacc tgctcactgc ctggaacagc tctcaaagtt     1500

tcctgtttta atgttaggtt ctgcttaaag gcagatggca aaggagtact tcccaggaaa     1560

cttaatttcc aggtggaact tcttttggat aaactcaagc aaaagggagc aattcgacga     1620

gcactgtttc tctacagcag gtccccaagt cactccaaga acatgactat ttcaaggggg     1680

ggactgatgc agtgtgagga attgatagcg tatctgcggg atgaatctga atttagagac     1740

aaactcactc caattactat ttttatggaa tatcggttgg attatagaac agctgctgat     1800

acaacaggct tgcaacccat tcttaaccag ttcacgcctg ctaacattag tcgacaggct     1860

cacattctac ttgactgtgg tgaagacaat gtctgtaaac ccaagctgga agtttctgta     1920

gatagtgatc aaaagaagat ctatattggg gatgacaacc ctctgacatt gattgttaag     1980

gctcagaatc aaggagaagg tgcctacgaa gctgagctca tcgtttccat tccactgcag     2040

gctgatttca tcggggttgt ccgaaacaat gaagccttag caagactttc ctgtgcattt     2100

aagacagaaa accaaactcg ccaggtggta tgtgaccttg gaaacccaat gaaggctgga     2160

actcaactct tagctggtct tcgtttcagt gtgcaccagc agtcagagat ggatacttct     2220

gtgaaatttg acttacaaat ccaaagctca aatctatttg acaaagtaag cccagttgta     2280

tctcacaaag ttgatcttgc tgttttagct gcagttgaga taagaggagt ctcgagtcct     2340

gatcatgtct ttcttccgat tccaaactgg gagcacaagg agaaccctga gactgaagaa     2400

gatgttgggc cagttgttca gcacatctat gagctgagaa acaatggtcc aagttcattc     2460

agcaaggcaa tgctccatct tcagtggcct tacaaatata ataataacac tctgttgtat     2520

atccttcatt atgatattga tggaccaatg aactgcactt cagatatgga gatcaaccct     2580

ttgagaatta agatctcatc tttgcaaaca actgaaaaga atgacacggt tgccgggcaa     2640

ggtgagcggg accatctcat cactaagcgg gatcttgccc tcagtgaagg agatattcac     2700

actttgggtt gtggagttgc tcagtgcttg aagattgtct gccaagttgg gagattagac     2760

agaggaaaga gtgcaatctt gtacgtaaag tcattactgt ggactgagac ttttatgaat     2820

aaagaaaatc agaatcattc ctattctctg aagtcgtctg cttcatttaa tgtcatagag     2880

tttccttata agaatcttcc aattgaggat atcaccaact ccacattggt taccactaat     2940

gtcacctggg gcattcagcc agcgcccatg cctgtgcctg tgtgggtgat cattttagca     3000

gttctagcag gattgttgct actggctgtt ttggtatttg taatgtacag gatgggcttt     3060

tttaaacggg tccggccacc tcaagaagaa caagaaaggg agcagcttca acctcatgaa     3120

aatggtgaag gaaactcaga aacttaa                                         3147


<210>  20
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH region

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Asn Leu Ser Cys Ala Val Ser Gly Phe Val Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Ser Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Cys Leu Ile Thr Thr Glu Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  21
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH region

<400>  21
gaagtgcagc tggtggagtc tggaggtggc ctggtgcagc ctggaggatc cctgaacctc       60

tcctgtgcag tctcaggatt cgtttttagt agatactgga tgagttgggt ccggcaggct      120

ccagggaaag ggctagaatg gattggagaa attaatccag atagcagtac gataaactat      180

acgtcatctc taaaggataa attcatcatc tccagagaca acgccaaaaa tacgttgtac      240

ctgcaaatga acaaagtgag atctgaggac acagcccttt attactgtgc atgtcttatt      300

actacggagg actactgggg tcaaggaacc tcagtcaccg tctcctca                   348


<210>  22
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL region

<400>  22

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Pro Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  23
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL region

<400>  23
gaaattgtgc tgactcagtc tccatcttcc atgtatgcat ctctaggaga gagagtcact       60

atcccttgca aggcgagtca ggacattaat agctatttaa gctggttcca gcagaaacca      120

gggaaatctc ctaagaccct gatctattat gcaaacagat tggtagatgg ggtcccatca      180

aggttcagtg gcagtggatc tgggcaagat tattctctca ccatcagcag cctggagtat      240

gaagatatgg gaatttatta ttgtctacag tatgatgagt ttccgtacac gttcggagga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  24
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH region

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Val Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Ser Ser Leu 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Ile Thr Thr Glu Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  25
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL region

<400>  25

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Arg Leu Val Asp Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  26
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2-23

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Val Phe Ser Arg Tyr 
            20                  25                  30          


Trp Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Ser Ser Leu 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Leu Ile Thr Thr Glu Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  27
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2-33

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Val Phe Ser Arg Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Ser Ser Leu 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Leu Ile Thr Thr Glu Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  28
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2-25

<400>  28

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Val Phe Ser Arg Ser 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Ser Ser Leu 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Leu Ile Thr Thr Glu Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  29
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P1-21

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Val Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Ser Ser Leu 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Leu Ile Thr Asp Glu Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  30
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P1-35

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Val Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Ser Ser Leu 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Phe Ile Thr Thr Glu Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  31
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C941

<400>  31

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  32
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P1-42

<400>  32

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  33
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2-16

<400>  33

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  34
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2-19

<400>  34

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Val Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  35
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2-36

<400>  35

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Val Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  36
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2-14

<400>  36

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ala Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


