                         SEQUENCE LISTING

<110>  Chiesi Farmaceutici SpA
 
<120>  Polypeptides having improved properties

<130>  NEO-416P1

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  82
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial polypeptide

<400>  1

Phe Pro Ile Pro Leu Pro Tyr Leu Trp Leu Leu Arg Ala Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Leu Ile Pro Lys Gly Gly Arg Leu Leu Pro Gln Leu 
            20                  25                  30          


Val Leu Arg Leu Val Leu Arg Leu Ser Gly Ser Gly Ser Gly Ser Gly 
        35                  40                  45              


Ser Ile Pro Ser Ser Pro Val His Leu Lys Arg Leu Lys Leu Leu Leu 
    50                  55                  60                  


Leu Leu Leu Leu Leu Ile Leu Leu Leu Ile Leu Gly Ala Leu Leu Leu 
65                  70                  75                  80  


Gly Leu 
        


<210>  2
<211>  70
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial polypeptide

<400>  2

Leu Trp Leu Cys Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile Pro 
1               5                   10                  15      


Lys Gly Gly Arg Leu Leu Pro Gln Leu Val Cys Arg Leu Val Leu Arg 
            20                  25                  30          


Leu Ser Gly Ser Gly Ile Pro Ser Ser Pro Val His Leu Lys Arg Leu 
        35                  40                  45              


Lys Leu Leu Leu Leu Leu Leu Leu Leu Ile Leu Leu Leu Ile Leu Gly 
    50                  55                  60                  


Ala Leu Leu Leu Gly Leu 
65                  70  


<210>  3
<211>  70
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial polypeptide

<400>  3

Leu Trp Leu Leu Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile Pro 
1               5                   10                  15      


Lys Gly Gly Arg Leu Leu Pro Gln Leu Val Leu Arg Leu Val Leu Arg 
            20                  25                  30          


Leu Ser Gly Ser Gly Ile Pro Ser Ser Pro Val His Leu Lys Arg Leu 
        35                  40                  45              


Lys Leu Leu Leu Leu Leu Leu Leu Leu Ile Leu Leu Leu Ile Leu Gly 
    50                  55                  60                  


Ala Leu Leu Leu Gly Leu 
65                  70  


<210>  4
<211>  70
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial polypeptide

<400>  4

Leu Trp Leu Leu Arg Ala Leu Ile Arg Arg Ile Gln Ala Leu Ile Pro 
1               5                   10                  15      


Arg Gly Gly Arg Leu Leu Pro Gln Leu Val Leu Arg Leu Val Leu Arg 
            20                  25                  30          


Leu Ser Gly Ser Gly Ile Pro Ser Ser Pro Val His Leu Arg Arg Leu 
        35                  40                  45              


Arg Leu Leu Leu Leu Leu Leu Leu Leu Ile Leu Leu Leu Ile Leu Gly 
    50                  55                  60                  


Ala Leu Leu Leu Gly Leu 
65                  70  


<210>  5
<211>  70
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial polypeptide

<400>  5

Leu Trp Leu Cys Arg Ala Leu Ile Arg Arg Ile Gln Ala Leu Ile Pro 
1               5                   10                  15      


Arg Gly Gly Arg Leu Leu Pro Gln Leu Val Cys Arg Leu Val Leu Arg 
            20                  25                  30          


Leu Ser Gly Ser Gly Ile Pro Ser Ser Pro Val His Leu Arg Arg Leu 
        35                  40                  45              


Arg Leu Leu Leu Leu Leu Leu Leu Leu Ile Leu Leu Leu Ile Leu Gly 
    50                  55                  60                  


Ala Leu Leu Leu Gly Leu 
65                  70  


<210>  6
<211>  7
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial peptide

<400>  6

Phe Pro Ile Pro Leu Pro Tyr 
1               5           


<210>  7
<211>  76
<212>  PRT
<213>  Unknown

<220>
<223>  artificial polypeptide


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  optional Phe residue

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  optional Pro residue

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  optional Ile residue

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  optional Pro residue

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  optional Leu residue

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  optional Pro residue

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  optional Tyr residue

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  residue selected from Leu, Ile and Cys

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  residue selected from Lys and Arg

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  residue selected from Lys and Arg

<220>
<221>  VARIANT
<222>  (17)..(17)
<223>  residue selected from Lys and Arg

<220>
<221>  VARIANT
<222>  (21)..(21)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  residue selected from Lys and Arg

<220>
<221>  VARIANT
<222>  (27)..(27)
<223>  residue selected from Lys and Arg

<220>
<221>  VARIANT
<222>  (28)..(28)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<220>
<221>  VARIANT
<222>  (34)..(34)
<223>  residue selected from Leu, Ile and Cys

<220>
<221>  VARIANT
<222>  (35)..(35)
<223>  residue selected from Lys and Arg

<220>
<221>  VARIANT
<222>  (39)..(39)
<223>  residue selected from Lys and Arg

<220>
<221>  VARIANT
<222>  (42)..(42)
<223>  (Gly-Ser)n with n ranging from 1 to 8

<220>
<221>  VARIANT
<222>  (43)..(43)
<223>  optional Gly residue

<220>
<221>  VARIANT
<222>  (52)..(52)
<223>  residue selected from Lys and Arg

<220>
<221>  VARIANT
<222>  (53)..(53)
<223>  residue selected from Lys and Arg

<220>
<221>  VARIANT
<222>  (54)..(54)
<223>  residue selected from Ile, Leu and nLeu

<220>
<221>  VARIANT
<222>  (55)..(55)
<223>  residue selected from Lys, Arg, His, Trp, Phe, Tyr and Orn

<220>
<221>  VARIANT
<222>  (56)..(69)
<223>  residue selected from Ile, Leu and nLeu

<220>
<221>  VARIANT
<222>  (74)..(74)
<223>  optional residue selected from Met, Met oxidized at sulfur atom, 
       Ile, Leu and nLeu

<220>
<221>  VARIANT
<222>  (75)..(75)
<223>  optional Gly residue

<220>
<221>  VARIANT
<222>  (76)..(76)
<223>  optional Leu residue

<400>  7

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Trp Leu Xaa Xaa Ala Leu Ile Glx 
1               5                   10                  15      


Glx Ile Gln Ala Xaa Ile Pro Xaa Gly Gly Xaa Xaa Leu Pro Gln Leu 
            20                  25                  30          


Val Xaa Xaa Leu Val Leu Xaa Leu Ser Xaa Xaa Ile Pro Ser Ser Pro 
        35                  40                  45              


Val His Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Gly Ala Leu Leu Xaa Xaa Xaa 
65                  70                  75      


<210>  8
<211>  76
<212>  PRT
<213>  Unknown

<220>
<223>  artificial polypeptide


<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  residue selected from Leu, Ile and Cys

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  residue selected from Lys and Arg

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  residue selected from Lys and Arg

<220>
<221>  VARIANT
<222>  (17)..(17)
<223>  residue selected from Lys and Arg

<220>
<221>  VARIANT
<222>  (21)..(21)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  residue selected from Lys and Arg

<220>
<221>  VARIANT
<222>  (27)..(27)
<223>  residue selected from Lys and Arg

<220>
<221>  VARIANT
<222>  (28)..(28)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<220>
<221>  VARIANT
<222>  (34)..(34)
<223>  residue selected from Leu, Ile and Cys

<220>
<221>  VARIANT
<222>  (35)..(35)
<223>  residue selected from Lys and Arg

<220>
<221>  VARIANT
<222>  (39)..(39)
<223>  residue selected from Lys and Arg

<220>
<221>  VARIANT
<222>  (42)..(42)
<223>  (Ser-Gly)n with n ranging from 1 to 4

<220>
<221>  VARIANT
<222>  (43)..(43)
<223>  optional Gly residue

<220>
<221>  VARIANT
<222>  (52)..(52)
<223>  residue selected from Lys and Arg

<220>
<221>  VARIANT
<222>  (53)..(53)
<223>  residue selected from Lys and Arg

<220>
<221>  VARIANT
<222>  (54)..(54)
<223>  residue selected from Ile, Leu and nLeu

<220>
<221>  VARIANT
<222>  (55)..(55)
<223>  residue selected from Lys, Arg, His, Trp, Phe, Tyr and Orn

<220>
<221>  VARIANT
<222>  (56)..(69)
<223>  residue selected from Ile, Leu and nLeu

<220>
<221>  VARIANT
<222>  (74)..(74)
<223>  optional residue selected from Met, Met oxidized at sulfur atom, 
       Ile, Leu and nLeu

<220>
<221>  VARIANT
<222>  (75)..(75)
<223>  optional Gly residue

<220>
<221>  VARIANT
<222>  (76)..(76)
<223>  optional Leu residue

<400>  8

Phe Pro Ile Pro Leu Pro Tyr Leu Trp Leu Xaa Xaa Ala Leu Ile Xaa 
1               5                   10                  15      


Xaa Ile Gln Ala Xaa Ile Pro Xaa Gly Gly Xaa Xaa Leu Pro Gln Leu 
            20                  25                  30          


Val Xaa Xaa Leu Val Leu Xaa Leu Ser Xaa Xaa Ile Pro Ser Ser Pro 
        35                  40                  45              


Val His Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Gly Ala Leu Leu Xaa Xaa Xaa 
65                  70                  75      


<210>  9
<211>  82
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial polypeptide


<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  residue selected from Leu, Ile and Cys

<220>
<221>  VARIANT
<222>  (21)..(21)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<220>
<221>  VARIANT
<222>  (28)..(28)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<220>
<221>  VARIANT
<222>  (34)..(34)
<223>  residue selected from Leu, Ile and Cys

<220>
<221>  VARIANT
<222>  (60)..(60)
<223>  residue selected from Ile, Leu and nLeu

<220>
<221>  VARIANT
<222>  (61)..(61)
<223>  residue selected from Lys, Arg, His, Trp, Phe, Tyr and Orn

<220>
<221>  VARIANT
<222>  (62)..(75)
<223>  residue selected from Ile, Leu and nLeu

<220>
<221>  VARIANT
<222>  (80)..(80)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<400>  9

Phe Pro Ile Pro Leu Pro Tyr Leu Trp Leu Xaa Arg Ala Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Xaa Ile Pro Lys Gly Gly Arg Xaa Leu Pro Gln Leu 
            20                  25                  30          


Val Xaa Arg Leu Val Leu Arg Leu Ser Gly Ser Gly Ser Gly Ser Gly 
        35                  40                  45              


Ser Ile Pro Ser Ser Pro Val His Leu Lys Arg Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Ala Leu Leu Xaa 
65                  70                  75                  80  


Gly Leu 
        


<210>  10
<211>  77
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial polypeptide


<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  residue selected from Leu, Ile and Cys

<220>
<221>  VARIANT
<222>  (21)..(21)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<220>
<221>  VARIANT
<222>  (28)..(28)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<220>
<221>  VARIANT
<222>  (34)..(34)
<223>  residue selected from Leu, Ile and Cys

<220>
<221>  VARIANT
<222>  (55)..(55)
<223>  residue selected from Ile, Leu and nLeu

<220>
<221>  VARIANT
<222>  (56)..(56)
<223>  residue selected from Lys, Arg, His, Trp, Phe, Tyr and Orn

<220>
<221>  VARIANT
<222>  (57)..(70)
<223>  residue selected from Ile, Leu and nLeu

<220>
<221>  VARIANT
<222>  (75)..(75)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<400>  10

Phe Pro Ile Pro Leu Pro Tyr Leu Trp Leu Xaa Arg Ala Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Xaa Ile Pro Lys Gly Gly Arg Xaa Leu Pro Gln Leu 
            20                  25                  30          


Val Xaa Arg Leu Val Leu Arg Leu Ser Gly Ser Gly Ile Pro Ser Ser 
        35                  40                  45              


Pro Val His Leu Lys Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Gly Ala Leu Leu Xaa Gly Leu 
65                  70                  75          


<210>  11
<211>  79
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial polypeptide


<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  residue selected from Leu, Ile and Cys

<220>
<221>  VARIANT
<222>  (21)..(21)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<220>
<221>  VARIANT
<222>  (28)..(28)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<220>
<221>  VARIANT
<222>  (34)..(34)
<223>  residue selected from Leu, Ile and Cys

<220>
<221>  VARIANT
<222>  (60)..(60)
<223>  residue selected from Ile, Leu and nLeu

<220>
<221>  VARIANT
<222>  (61)..(61)
<223>  residue selected from Lys, Arg, His, Trp, Phe, Tyr and Orn

<220>
<221>  VARIANT
<222>  (62)..(75)
<223>  residue selected from Ile, Leu and nLeu

<400>  11

Phe Pro Ile Pro Leu Pro Tyr Leu Trp Leu Xaa Arg Ala Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Xaa Ile Pro Lys Gly Gly Arg Xaa Leu Pro Gln Leu 
            20                  25                  30          


Val Xaa Arg Leu Val Leu Arg Leu Ser Gly Ser Gly Ser Gly Ser Gly 
        35                  40                  45              


Ser Ile Pro Ser Ser Pro Val His Leu Lys Arg Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Ala Leu Leu 
65                  70                  75                  


<210>  12
<211>  74
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial polypeptide


<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  residue selected from Leu, Ile and Cys

<220>
<221>  VARIANT
<222>  (21)..(21)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<220>
<221>  VARIANT
<222>  (28)..(28)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<220>
<221>  VARIANT
<222>  (34)..(34)
<223>  residue selected from Leu, Ile and Cys

<220>
<221>  VARIANT
<222>  (55)..(55)
<223>  residue selected from Ile, Leu and nLeu

<220>
<221>  VARIANT
<222>  (56)..(56)
<223>  residue selected from Lys, Arg, His, Trp, Phe, Tyr and Orn

<220>
<221>  VARIANT
<222>  (57)..(70)
<223>  residue selected from Ile, Leu and nLeu

<400>  12

Phe Pro Ile Pro Leu Pro Tyr Leu Trp Leu Xaa Arg Ala Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Xaa Ile Pro Lys Gly Gly Arg Xaa Leu Pro Gln Leu 
            20                  25                  30          


Val Xaa Arg Leu Val Leu Arg Leu Ser Gly Ser Gly Ile Pro Ser Ser 
        35                  40                  45              


Pro Val His Leu Lys Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Gly Ala Leu Leu 
65                  70                  


<210>  13
<211>  69
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial polypeptide


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  residue selected from Leu, Ile and Cys

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<220>
<221>  VARIANT
<222>  (21)..(21)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<220>
<221>  VARIANT
<222>  (27)..(27)
<223>  residue selected from Leu, Ile and Cys

<220>
<221>  VARIANT
<222>  (35)..(35)
<223>  (Gly-Ser)n with n ranging from 1 to 4

<220>
<221>  VARIANT
<222>  (36)..(36)
<223>  optional Gly residue

<220>
<221>  VARIANT
<222>  (47)..(47)
<223>  residue selected from Ile, Leu and nLeu

<220>
<221>  VARIANT
<222>  (48)..(48)
<223>  residue selected from Lys, Arg, His, Trp, Phe, Tyr and Orn

<220>
<221>  VARIANT
<222>  (49)..(62)
<223>  residue selected from Ile, Leu and nLeu

<220>
<221>  VARIANT
<222>  (67)..(67)
<223>  optional residue selected from Met, Met oxidized at sulfur atom, 
       Ile, Leu and nLeu

<220>
<221>  VARIANT
<222>  (68)..(68)
<223>  optional Gly residue

<220>
<221>  VARIANT
<222>  (69)..(69)
<223>  optional Leu residue

<400>  13

Leu Trp Leu Xaa Arg Ala Leu Ile Lys Arg Ile Gln Ala Xaa Ile Pro 
1               5                   10                  15      


Lys Gly Gly Arg Xaa Leu Pro Gln Leu Val Xaa Arg Leu Val Leu Arg 
            20                  25                  30          


Leu Ser Xaa Xaa Ile Pro Ser Ser Pro Val His Leu Lys Arg Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Ala 
    50                  55                  60                  


Leu Leu Xaa Xaa Xaa 
65                  


<210>  14
<211>  75
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial polypeptide


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  residue selected from Leu, Ile and Cys

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<220>
<221>  VARIANT
<222>  (21)..(21)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<220>
<221>  VARIANT
<222>  (27)..(27)
<223>  residue selected from Leu, Ile and Cys

<220>
<221>  VARIANT
<222>  (53)..(53)
<223>  residue selected from Ile, Leu and nLeu

<220>
<221>  VARIANT
<222>  (54)..(54)
<223>  residue selected from Lys, Arg, His, Trp, Phe, Tyr and Orn

<220>
<221>  VARIANT
<222>  (55)..(68)
<223>  residue selected from Ile, Leu and nLeu

<220>
<221>  VARIANT
<222>  (73)..(73)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<400>  14

Leu Trp Leu Xaa Arg Ala Leu Ile Lys Arg Ile Gln Ala Xaa Ile Pro 
1               5                   10                  15      


Lys Gly Gly Arg Xaa Leu Pro Gln Leu Val Xaa Arg Leu Val Leu Arg 
            20                  25                  30          


Leu Ser Gly Ser Gly Ser Gly Ser Gly Ser Ile Pro Ser Ser Pro Val 
        35                  40                  45              


His Leu Lys Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Gly Ala Leu Leu Xaa Gly Leu 
65                  70                  75  


<210>  15
<211>  70
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial polypeptide


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  residue selected from Leu, Ile and Cys

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<220>
<221>  VARIANT
<222>  (21)..(21)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<220>
<221>  VARIANT
<222>  (27)..(27)
<223>  residue selected from Leu, Ile and Cys

<220>
<221>  VARIANT
<222>  (48)..(48)
<223>  residue selected from Ile, Leu and nLeu

<220>
<221>  VARIANT
<222>  (49)..(49)
<223>  residue selected from Lys, Arg, His, Trp, Phe, Tyr and Orn

<220>
<221>  VARIANT
<222>  (50)..(63)
<223>  residue selected from Ile, Leu and nLeu

<220>
<221>  VARIANT
<222>  (68)..(68)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<400>  15

Leu Trp Leu Xaa Arg Ala Leu Ile Lys Arg Ile Gln Ala Xaa Ile Pro 
1               5                   10                  15      


Lys Gly Gly Arg Xaa Leu Pro Gln Leu Val Xaa Arg Leu Val Leu Arg 
            20                  25                  30          


Leu Ser Gly Ser Gly Ile Pro Ser Ser Pro Val His Leu Lys Arg Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly 
    50                  55                  60                  


Ala Leu Leu Xaa Gly Leu 
65                  70  


<210>  16
<211>  72
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial polypeptide


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  residue selected from Leu, Ile and Cys

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<220>
<221>  VARIANT
<222>  (21)..(21)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<220>
<221>  VARIANT
<222>  (27)..(27)
<223>  residue selected from Leu, Ile and Cys

<220>
<221>  VARIANT
<222>  (53)..(53)
<223>  residue selected from Ile, Leu and nLeu

<220>
<221>  VARIANT
<222>  (54)..(54)
<223>  residue selected from Lys, Arg, His, Trp, Phe, Tyr and Orn

<220>
<221>  VARIANT
<222>  (55)..(68)
<223>  residue selected from Ile, Leu and nLeu

<400>  16

Leu Trp Leu Xaa Arg Ala Leu Ile Lys Arg Ile Gln Ala Xaa Ile Pro 
1               5                   10                  15      


Lys Gly Gly Arg Xaa Leu Pro Gln Leu Val Xaa Arg Leu Val Leu Arg 
            20                  25                  30          


Leu Ser Gly Ser Gly Ser Gly Ser Gly Ser Ile Pro Ser Ser Pro Val 
        35                  40                  45              


His Leu Lys Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Gly Ala Leu Leu 
65                  70          


<210>  17
<211>  67
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial polypeptide


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  residue selected from Leu, Ile and Cys

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<220>
<221>  VARIANT
<222>  (21)..(21)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<220>
<221>  VARIANT
<222>  (27)..(27)
<223>  residue selected from Leu, Ile and Cys

<220>
<221>  VARIANT
<222>  (48)..(48)
<223>  residue selected from Ile, Leu and nLeu

<220>
<221>  VARIANT
<222>  (49)..(49)
<223>  residue selected from Lys, Arg, His, Trp, Phe, Tyr and Orn

<220>
<221>  VARIANT
<222>  (50)..(63)
<223>  residue selected from Ile, Leu and nLeu

<400>  17

Leu Trp Leu Xaa Arg Ala Leu Ile Lys Arg Ile Gln Ala Xaa Ile Pro 
1               5                   10                  15      


Lys Gly Gly Arg Xaa Leu Pro Gln Leu Val Xaa Arg Leu Val Leu Arg 
            20                  25                  30          


Leu Ser Gly Ser Gly Ile Pro Ser Ser Pro Val His Leu Lys Arg Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly 
    50                  55                  60                  


Ala Leu Leu 
65          


<210>  18
<211>  76
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial polypeptide


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  optional Phe residue

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  optional Pro residue

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  optional Ile residue

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  optional Pro residue

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  optional Leu residue

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  optional Pro residue

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  optional Tyr residue

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  residue selected from Leu, Ile and Cys

<220>
<221>  VARIANT
<222>  (21)..(21)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<220>
<221>  VARIANT
<222>  (28)..(28)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<220>
<221>  VARIANT
<222>  (34)..(34)
<223>  residue selected from Leu, Ile and Cys

<220>
<221>  VARIANT
<222>  (42)..(42)
<223>  (Gly-Ser)n with n ranging from 1 to 4

<220>
<221>  VARIANT
<222>  (43)..(43)
<223>  optional Gly residue

<220>
<221>  VARIANT
<222>  (54)..(54)
<223>  residue selected from Ile, Leu and nLeu

<220>
<221>  VARIANT
<222>  (55)..(55)
<223>  residue selected from Lys, Arg, His, Trp, Phe, Tyr and Orn

<220>
<221>  VARIANT
<222>  (74)..(74)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<400>  18

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Trp Leu Xaa Arg Ala Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Xaa Ile Pro Lys Gly Gly Arg Xaa Leu Pro Gln Leu 
            20                  25                  30          


Val Xaa Arg Leu Val Leu Arg Leu Ser Xaa Xaa Ile Pro Ser Ser Pro 
        35                  40                  45              


Val His Leu Lys Arg Xaa Xaa Leu Leu Leu Leu Leu Leu Leu Leu Ile 
    50                  55                  60                  


Leu Leu Leu Ile Leu Gly Ala Leu Leu Xaa Gly Leu 
65                  70                  75      


<210>  19
<211>  76
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial polypeptide


<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  residue selected from Leu, Ile and Cys

<220>
<221>  VARIANT
<222>  (21)..(21)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<220>
<221>  VARIANT
<222>  (28)..(28)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<220>
<221>  VARIANT
<222>  (34)..(34)
<223>  residue selected from Leu, Ile and Cys

<220>
<221>  VARIANT
<222>  (42)..(42)
<223>  (Gly-Ser)n with n ranging from 1 to 4

<220>
<221>  VARIANT
<222>  (43)..(43)
<223>  optional Gly residue

<220>
<221>  VARIANT
<222>  (54)..(54)
<223>  residue selected from Ile, Leu and nLeu

<220>
<221>  VARIANT
<222>  (55)..(55)
<223>  residue selected from Lys, Arg, His, Trp, Phe, Tyr and Orn

<220>
<221>  VARIANT
<222>  (74)..(74)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<400>  19

Phe Pro Ile Pro Leu Pro Tyr Leu Trp Leu Xaa Arg Ala Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Xaa Ile Pro Lys Gly Gly Arg Xaa Leu Pro Gln Leu 
            20                  25                  30          


Val Xaa Arg Leu Val Leu Arg Leu Ser Xaa Xaa Ile Pro Ser Ser Pro 
        35                  40                  45              


Val His Leu Lys Arg Xaa Xaa Leu Leu Leu Leu Leu Leu Leu Leu Ile 
    50                  55                  60                  


Leu Leu Leu Ile Leu Gly Ala Leu Leu Xaa Gly Leu 
65                  70                  75      


<210>  20
<211>  69
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial polypeptide


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  residue selected from Leu, Ile and Cys

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<220>
<221>  VARIANT
<222>  (21)..(21)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<220>
<221>  VARIANT
<222>  (27)..(27)
<223>  residue selected from Leu, Ile and Cys

<220>
<221>  VARIANT
<222>  (35)..(35)
<223>  (Gly-Ser)n with n ranging from 1 to 4

<220>
<221>  VARIANT
<222>  (36)..(36)
<223>  optional Gly residue

<220>
<221>  VARIANT
<222>  (47)..(47)
<223>  residue selected from Ile, Leu and nLeu

<220>
<221>  VARIANT
<222>  (48)..(48)
<223>  residue selected from Lys, Arg, His, Trp, Phe, Tyr and Orn

<220>
<221>  VARIANT
<222>  (67)..(67)
<223>  residue selected from Met, Met oxidized at sulfur atom, Ile, Leu 
       and nLeu

<400>  20

Leu Trp Leu Xaa Arg Ala Leu Ile Lys Arg Ile Gln Ala Xaa Ile Pro 
1               5                   10                  15      


Lys Gly Gly Arg Xaa Leu Pro Gln Leu Val Xaa Arg Leu Val Leu Arg 
            20                  25                  30          


Leu Ser Xaa Xaa Ile Pro Ser Ser Pro Val His Leu Lys Arg Xaa Xaa 
        35                  40                  45              


Leu Leu Leu Leu Leu Leu Leu Leu Ile Leu Leu Leu Ile Leu Gly Ala 
    50                  55                  60                  


Leu Leu Xaa Gly Leu 
65                  


