               SEQUENCE LISTING

<110> CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC)

<120> Cianobacteria recombinante sobreproductora de sacarosa

<130> PCT1641.1491

<150> ES P202030042
<151> 2020-01-21

<160> 20

<170> BiSSAP 1.3.6

<210> 1
<211> 549
<212> PRT
<213> Escherichia coli


<400> 1
Met Lys Asn Ile Asn Pro Thr Gln Thr Ala Ala Trp Gln Ala Leu Gln 
1               5                   10                  15      
Lys His Phe Asp Glu Met Lys Asp Val Thr Ile Ala Asp Leu Phe Ala 
            20                  25                  30          
Lys Asp Gly Asp Arg Phe Ser Lys Phe Ser Ala Thr Phe Asp Asp Gln 
        35                  40                  45              
Met Leu Val Asp Tyr Ser Lys Asn Arg Ile Thr Glu Glu Thr Leu Ala 
    50                  55                  60                  
Lys Leu Gln Asp Leu Ala Lys Glu Cys Asp Leu Ala Gly Ala Ile Lys 
65                  70                  75                  80  
Ser Met Phe Ser Gly Glu Lys Ile Asn Arg Thr Glu Asn Arg Ala Val 
                85                  90                  95      
Leu His Val Ala Leu Arg Asn Arg Ser Asn Thr Pro Ile Leu Val Asp 
            100                 105                 110         
Gly Lys Asp Val Met Pro Glu Val Asn Ala Val Leu Glu Lys Met Lys 
        115                 120                 125             
Thr Phe Ser Glu Ala Ile Ile Ser Gly Glu Trp Lys Gly Tyr Thr Gly 
    130                 135                 140                 
Lys Ala Ile Thr Asp Val Val Asn Ile Gly Ile Gly Gly Ser Asp Leu 
145                 150                 155                 160 
Gly Pro Tyr Met Val Thr Glu Ala Leu Arg Pro Tyr Lys Asn His Leu 
                165                 170                 175     
Asn Met His Phe Val Ser Asn Val Asp Gly Thr His Ile Ala Glu Val 
            180                 185                 190         
Leu Lys Lys Val Asn Pro Glu Thr Thr Leu Phe Leu Val Ala Ser Lys 
        195                 200                 205             
Thr Phe Thr Thr Gln Glu Thr Met Thr Asn Ala His Ser Ala Arg Asp 
    210                 215                 220                 
Trp Phe Leu Lys Ala Ala Gly Asp Glu Lys His Val Ala Lys His Phe 
225                 230                 235                 240 
Ala Ala Leu Ser Thr Asn Ala Lys Ala Val Gly Glu Phe Gly Ile Asp 
                245                 250                 255     
Thr Ala Asn Met Phe Glu Phe Trp Asp Trp Val Gly Gly Arg Tyr Ser 
            260                 265                 270         
Leu Trp Ser Ala Ile Gly Leu Ser Ile Val Leu Ser Ile Gly Phe Asp 
        275                 280                 285             
Asn Phe Val Glu Leu Leu Ser Gly Ala His Ala Met Asp Lys His Phe 
    290                 295                 300                 
Ser Thr Thr Pro Ala Glu Lys Asn Leu Pro Val Leu Leu Ala Leu Ile 
305                 310                 315                 320 
Gly Ile Trp Tyr Asn Asn Phe Phe Gly Ala Glu Thr Glu Ala Ile Leu 
                325                 330                 335     
Pro Tyr Asp Gln Tyr Met His Arg Phe Ala Ala Tyr Phe Gln Gln Gly 
            340                 345                 350         
Asn Met Glu Ser Asn Gly Lys Tyr Val Asp Arg Asn Gly Asn Val Val 
        355                 360                 365             
Asp Tyr Gln Thr Gly Pro Ile Ile Trp Gly Glu Pro Gly Thr Asn Gly 
    370                 375                 380                 
Gln His Ala Phe Tyr Gln Leu Ile His Gln Gly Thr Lys Met Val Pro 
385                 390                 395                 400 
Cys Asp Phe Ile Ala Pro Ala Ile Thr His Asn Pro Leu Ser Asp His 
                405                 410                 415     
His Gln Lys Leu Leu Ser Asn Phe Phe Ala Gln Thr Glu Ala Leu Ala 
            420                 425                 430         
Phe Gly Lys Ser Arg Glu Val Val Glu Gln Glu Tyr Arg Asp Gln Gly 
        435                 440                 445             
Lys Asp Pro Ala Thr Leu Asp Tyr Val Val Pro Phe Lys Val Phe Glu 
    450                 455                 460                 
Gly Asn Arg Pro Thr Asn Ser Ile Leu Leu Arg Glu Ile Thr Pro Phe 
465                 470                 475                 480 
Ser Leu Gly Ala Leu Ile Ala Leu Tyr Glu His Lys Ile Phe Thr Gln 
                485                 490                 495     
Gly Val Ile Leu Asn Ile Phe Thr Phe Asp Gln Trp Gly Val Glu Leu 
            500                 505                 510         
Gly Lys Gln Leu Ala Asn Arg Ile Leu Pro Glu Leu Lys Asp Asp Lys 
        515                 520                 525             
Glu Ile Ser Ser His Asp Ser Ser Thr Asn Gly Leu Ile Asn Arg Tyr 
    530                 535                 540                 
Lys Ala Trp Arg Gly 
545                 

<210> 2
<211> 1650
<212> DNA
<213> Escherichia coli


<400> 2
atgaaaaaca tcaatccaac gcagaccgct gcctggcagg cactacagaa acacttcgat      60

gaaatgaaag acgttacgat cgccgatctt tttgctaaag acggcgatcg tttttctaag     120

ttctccgcaa ccttcgacga tcagatgctg gtggattact ccaaaaaccg catcactgaa     180

gagacgctgg cgaaattaca ggatctggcg aaagagtgcg atctggcggg cgcgattaag     240

tcgatgttct ctggcgagaa gatcaaccgc actgaaaacc gcgccgtgct gcacgtagcg     300

ctgcgtaacc gtagcaatac cccgattttg gttgatggca aagacgtaat gccggaagtc     360

aacgcggtgc tggagaagat gaaaaccttc tcagaagcga ttatttccgg tgagtggaaa     420

ggttataccg gcaaagcaat cactgacgta gtgaacatcg ggatcggcgg ttctgacctc     480

ggcccataca tggtgaccga agctctgcgt ccgtacaaaa accacctgaa catgcacttt     540

gtttctaacg tcgatgggac tcacatcgcg gaagtgctga aaaaagtaaa cccggaaacc     600

acgctgttct tggtagcatc taaaaccttc accactcagg aaactatgac caacgcccat     660

agcgcgcgtg actggttcct gaaagcggca ggtgatgaaa aacacgttgc aaaacacttt     720

gcggcgcttt ccaccaatgc caaagccgtt ggcgagtttg gtattgatac tgccaacatg     780

ttcgagttct gggactgggt tggcggccgt tactctttgt ggtcagcgat tggcctgtcg     840

attgttctct ccatcggctt tgataacttc gttgaactgc tttccggcgc acacgcgatg     900

gacaagcatt tctccaccac gcctgccgag aaaaacctgc ctgtactgct ggcgctgatt     960

ggcatctggt acaacaattt ctttggtgcg gaaactgaag cgattctgcc gtatgaccag    1020

tatatgcacc gtttcgcggc gtacttccag cagggcaata tggagtccaa cggtaagtat    1080

gttgaccgta acggtaacgt tgtggattac cagactggcc cgattatctg gggtgaacca    1140

ggcactaacg gtcagcacgc gttctaccag ctgatccacc agggaaccaa aatggtaccg    1200

tgcgatttca tcgctccggc tatcacccat aacccgctct ctgatcatca ccagaaactg    1260

ctgtctaact tcttcgccca gaccgaagcg ctggcgtttg gtaaatcccg cgaagtggtt    1320

gagcaggaat atcgtgatca gggtaaagat ccggcaacgc ttgactacgt ggtgccgttc    1380

aaagtattcg aaggtaaccg cccgaccaac tccatcctgc tgcgtgaaat cactccgttc    1440

agcctgggtg cgttgattgc gctgtatgag cacaaaatct ttactcaggg cgtgatcctg    1500

aacatcttca ccttcgacca gtggggcgtg gaactgggta aacagctggc gaaccgtatt    1560

ctgccagagc tgaaagatga taaagaaatc agcagccacg atagctcgac caatggtctg    1620

attaaccgct ataaagcgtg gcgcggttaa                                     1650


<210> 3
<211> 1650
<212> DNA
<213> Artificial Sequence


<220> 
<223> Secuencia de nucleótidos que codifica PGI optimizada para su
      expresión en Synechococcus elongatus

<400> 3
atgaaaaaca tcaatccaac gcagaccgct gcctggcagg cactacagaa acacttcgat      60

gaaatgaaag acgttacgat cgccgatctt tttgctaaag acggcgatcg cttttctaag     120

ttctccgcaa ccttcgacga tcagatgctg gtggattact ccaaaaaccg catcactgaa     180

gagacgctgg cgaaattaca ggatctggcg aaagagtgcg atctggcggg cgcgattaag     240

tcgatgttct cgggcgagaa gatcaaccgc actgaaaacc gcgccgtgct gcacgtggcg     300

ctgcgtaacc gcagcaatac cccgattttg gttgatggca aagacgtcat gccggaagtc     360

aacgcggtgc tggagaagat gaaaaccttc tcagaagcga ttatttccgg tgagtggaaa     420

ggttataccg gcaaagcaat cactgacgta gtgaacatcg ggatcggcgg ttcggacctc     480

ggcccataca tggtgaccga agctctgcgg ccgtacaaaa accacctgaa catgcacttt     540

gtttctaacg tcgatgggac tcacatcgcg gaagtgctga aaaaagtgaa cccggaaacc     600

acgctgttct tggtagcatc gaaaaccttc accactcagg aaactatgac caacgcccat     660

agcgcgcgtg actggttcct gaaagcggca ggtgatgaaa aacacgttgc aaaacacttt     720

gcggcgcttt ccaccaatgc caaagccgtt ggcgagtttg gtattgatac tgccaacatg     780

ttcgagttct gggactgggt tggcggccgg tactctttgt ggtcagcgat tggcctgtcg     840

attgttctct ccatcggctt tgataacttc gttgaactgc tttccggcgc acacgcgatg     900

gacaagcatt tctccaccac gcctgccgag aaaaacctgc ctgtcctgct ggcgctgatt     960

ggcatctggt acaacaattt ctttggtgcg gaaactgaag cgattctgcc gtatgaccag    1020

tatatgcacc gtttcgcggc gtacttccag cagggcaata tggagtccaa cggtaagtat    1080

gttgaccgta acggtaacgt tgtggattac cagactggcc cgattatctg gggtgaacca    1140

ggcactaacg gtcagcacgc gttctaccag ctgatccacc agggaaccaa aatggtgccg    1200

tgcgatttca tcgctccggc tatcacccat aacccgctct ctgatcatca ccagaaactg    1260

ctgtcgaact tcttcgccca gaccgaagcg ctggcgtttg gtaaatcccg cgaagtggtt    1320

gagcaggaat atcgcgatca gggtaaagat ccggcaacgc ttgactacgt ggtgccgttc    1380

aaagtattcg aaggtaaccg cccgaccaac tccatcctgc tgcgtgaaat cactccgttc    1440

agcctgggtg cgttgattgc gctgtatgag cacaaaatct ttactcaggg cgtgatcctg    1500

aacatcttca ccttcgacca gtggggcgtg gaactgggta aacagctggc gaaccgtatt    1560

ctgccagagc tgaaagatga taaagaaatc agcagccacg atagctcgac caatggtctg    1620

attaaccgct ataaagcgtg gcgcggttaa                                     1650


<210> 4
<211> 546
<212> PRT
<213> Escherichia coli


<400> 4
Met Ala Ile His Asn Arg Ala Gly Gln Pro Ala Gln Gln Ser Asp Leu 
1               5                   10                  15      
Ile Asn Val Ala Gln Leu Thr Ala Gln Tyr Tyr Val Leu Lys Pro Glu 
            20                  25                  30          
Ala Gly Asn Ala Glu His Ala Val Lys Phe Gly Thr Ser Gly His Arg 
        35                  40                  45              
Gly Ser Ala Ala Arg His Ser Phe Asn Glu Pro His Ile Leu Ala Ile 
    50                  55                  60                  
Ala Gln Ala Ile Ala Glu Glu Arg Ala Lys Asn Gly Ile Thr Gly Pro 
65                  70                  75                  80  
Cys Tyr Val Gly Lys Asp Thr His Ala Leu Ser Glu Pro Ala Phe Ile 
                85                  90                  95      
Ser Val Leu Glu Val Leu Ala Ala Asn Gly Val Asp Val Ile Val Gln 
            100                 105                 110         
Glu Asn Asn Gly Phe Thr Pro Thr Pro Ala Val Ser Asn Ala Ile Leu 
        115                 120                 125             
Val His Asn Lys Lys Gly Gly Pro Leu Ala Asp Gly Ile Val Ile Thr 
    130                 135                 140                 
Pro Ser His Asn Pro Pro Glu Asp Gly Gly Ile Lys Tyr Asn Pro Pro 
145                 150                 155                 160 
Asn Gly Gly Pro Ala Asp Thr Asn Val Thr Lys Val Val Glu Asp Arg 
                165                 170                 175     
Ala Asn Ala Leu Leu Ala Asp Gly Leu Lys Gly Val Lys Arg Ile Ser 
            180                 185                 190         
Leu Asp Glu Ala Met Ala Ser Gly His Val Lys Glu Gln Asp Leu Val 
        195                 200                 205             
Gln Pro Phe Val Glu Gly Leu Ala Asp Ile Val Asp Met Ala Ala Ile 
    210                 215                 220                 
Gln Lys Ala Gly Leu Thr Leu Gly Val Asp Pro Leu Gly Gly Ser Gly 
225                 230                 235                 240 
Ile Glu Tyr Trp Lys Arg Ile Gly Glu Tyr Tyr Asn Leu Asn Leu Thr 
                245                 250                 255     
Ile Val Asn Asp Gln Val Asp Gln Thr Phe Arg Phe Met His Leu Asp 
            260                 265                 270         
Lys Asp Gly Ala Ile Arg Met Asp Cys Ser Ser Glu Cys Ala Met Ala 
        275                 280                 285             
Gly Leu Leu Ala Leu Arg Asp Lys Phe Asp Leu Ala Phe Ala Asn Asp 
    290                 295                 300                 
Pro Asp Tyr Asp Arg His Gly Ile Val Thr Pro Ala Gly Leu Met Asn 
305                 310                 315                 320 
Pro Asn His Tyr Leu Ala Val Ala Ile Asn Tyr Leu Phe Gln His Arg 
                325                 330                 335     
Pro Gln Trp Gly Lys Asp Val Ala Val Gly Lys Thr Leu Val Ser Ser 
            340                 345                 350         
Ala Met Ile Asp Arg Val Val Asn Asp Leu Gly Arg Lys Leu Val Glu 
        355                 360                 365             
Val Pro Val Gly Phe Lys Trp Phe Val Asp Gly Leu Phe Asp Gly Ser 
    370                 375                 380                 
Phe Gly Phe Gly Gly Glu Glu Ser Ala Gly Ala Ser Phe Leu Arg Phe 
385                 390                 395                 400 
Asp Gly Thr Pro Trp Ser Thr Asp Lys Asp Gly Ile Ile Met Cys Leu 
                405                 410                 415     
Leu Ala Ala Glu Ile Thr Ala Val Thr Gly Lys Asn Pro Gln Glu His 
            420                 425                 430         
Tyr Asn Glu Leu Ala Lys Arg Phe Gly Ala Pro Ser Tyr Asn Arg Leu 
        435                 440                 445             
Gln Ala Ala Ala Thr Ser Ala Gln Lys Ala Ala Leu Ser Lys Leu Ser 
    450                 455                 460                 
Pro Glu Met Val Ser Ala Ser Thr Leu Ala Gly Asp Pro Ile Thr Ala 
465                 470                 475                 480 
Arg Leu Thr Ala Ala Pro Gly Asn Gly Ala Ser Ile Gly Gly Leu Lys 
                485                 490                 495     
Val Met Thr Asp Asn Gly Trp Phe Ala Ala Arg Pro Ser Gly Thr Glu 
            500                 505                 510         
Asp Ala Tyr Lys Ile Tyr Cys Glu Ser Phe Leu Gly Glu Glu His Arg 
        515                 520                 525             
Lys Gln Ile Glu Lys Glu Ala Val Glu Ile Val Ser Glu Val Leu Lys 
    530                 535                 540                 
Asn Ala 
545     

<210> 5
<211> 1641
<212> DNA
<213> Escherichia coli


<400> 5
atggcaatcc acaatcgtgc aggccaacct gcacaacaga gtgatttgat taacgtcgcc      60

caactgacgg cgcaatatta tgtactgaaa ccagaagcag ggaatgcgga gcacgcggtg     120

aaattcggta cttccggtca ccgtggcagt gcagcgcgcc acagctttaa cgagccgcac     180

attctggcga tcgctcaggc aattgctgaa gaacgtgcga aaaacggcat cactggccct     240

tgctatgtgg gtaaagatac tcacgccctg tccgaacctg cattcatttc cgttctggaa     300

gtgctggcag cgaacggcgt tgatgtcatt gtgcaggaaa acaatggctt caccccgacg     360

cctgccgttt ccaatgccat cctggttcac aataaaaaag gtggcccgct ggcagacggt     420

atcgtgatta caccgtccca taacccgccg gaagatggtg gaatcaaata caatccgcca     480

aatggtggcc cggctgatac caacgtcact aaagtggtgg aagacagggc caacgcactg     540

ctggccgatg gcctgaaagg cgtgaagcgt atctccctcg acgaagcgat ggcatccggt     600

catgtgaaag agcaggatct ggtgcagccg ttcgtggaag gtctggccga tatcgttgat     660

atggccgcga ttcagaaagc gggcctgacg ctgggcgttg atccgctggg cggttccggt     720

atcgaatact ggaagcgtat tggcgagtat tacaacctca acctgactat cgttaacgat     780

caggtcgatc aaaccttccg ctttatgcac cttgataaag acggcgcgat ccgtatggac     840

tgctcctccg agtgtgcgat ggcgggcctg ctggcactgc gtgataagtt cgatctggcg     900

tttgctaacg acccggatta tgaccgtcac ggtatcgtca ctccggcagg tttgatgaat     960

ccgaaccact acctggcggt ggcaatcaat tacctgttcc agcatcgtcc gcagtggggc    1020

aaagatgttg ccgtcggtaa aacgctggtt tcatctgcga tgatcgaccg tgtggtcaac    1080

gacttgggcc gtaaactggt agaagtcccg gtaggtttca aatggtttgt cgatggtctg    1140

ttcgacggca gcttcggctt tggcggcgaa gagagtgcag gggcttcctt cctgcgtttc    1200

gacggcacgc cgtggtccac cgacaaagac ggcatcatca tgtgtctgct ggcggcggaa    1260

atcaccgctg tcaccggtaa gaacccgcag gaacactaca acgaactggc aaaacgcttt    1320

ggtgcgccga gctacaaccg tttgcaggca gctgcgactt ccgcacaaaa agcggcgctg    1380

tctaagctgt ctccggaaat ggtgagcgcc agcaccctgg caggtgaccc gatcaccgcg    1440

cgcctgactg ctgctccggg caacggtgct tctattggcg gtctgaaagt gatgactgac    1500

aacggctggt tcgccgcgcg tccgtcaggc acggaagacg catataagat ctactgcgaa    1560

agcttcctcg gtgaagaaca tcgcaagcag attgagaaag aagcggttga gattgttagc    1620

gaagttctga aaaacgcgta a                                              1641


<210> 6
<211> 1641
<212> DNA
<213> Artificial Sequence


<220> 
<223> Secuencia de nucleótidos que codifica PGMT optimizada para su
      expresión en S. elongatus.

<400> 6
atggcaatcc acaatcgcgc aggccaacct gcacaacaga gtgatttgat taacgtcgcc      60

caactgacgg cgcaatatta tgtgctgaaa ccagaagcag ggaatgcgga gcacgcggtg     120

aaattcggta cttccggtca ccggggcagt gcagcgcgcc acagctttaa cgagccgcac     180

attctggcga tcgctcaggc aattgctgaa gaacgcgcga aaaacggcat cactggccct     240

tgctatgtgg gtaaagatac tcacgccctg tccgaacctg cattcatttc cgttctggaa     300

gtgctggcag cgaacggcgt tgatgtcatt gtgcaggaaa acaatggctt caccccgacg     360

cctgccgttt ccaatgccat cctggttcac aataaaaaag gtggcccgct ggcagacggt     420

atcgtgatta caccgtccca taacccgccg gaagatggtg gaatcaaata caatccgcca     480

aatggtggcc cggctgatac caacgtcact aaagtggtgg aggaccgggc caacgcactg     540

ctggccgatg gcctgaaagg cgtgaagcgt atctccctcg acgaagcgat ggcatccggt     600

catgtgaaag agcaggatct ggtgcagccg ttcgtggaag gtctggccga tatcgttgat     660

atggccgcga ttcagaaagc gggcctgacg ctgggcgttg atccgctggg cggttccggt     720

atcgaatact ggaagcgcat tggcgagtat tacaacctca acctgactat cgttaacgat     780

caggtcgatc aaaccttccg ctttatgcac cttgataaag acggcgcgat ccgtatggac     840

tgctcctccg agtgtgcgat ggcgggcctg ctggcactgc gtgataagtt cgatctggcg     900

tttgctaacg acccggatta tgaccgccac ggtatcgtca ctccggcagg tttgatgaat     960

ccgaaccact acctggcggt ggcaatcaat tacctgttcc agcatcgtcc gcagtggggc    1020

aaagatgttg ccgtcggtaa aacgctggtt tcatcggcga tgatcgaccg tgtggtcaac    1080

gacttgggcc gtaaactggt agaagtcccg gtaggtttca aatggtttgt cgatggtctg    1140

ttcgacggca gcttcggctt tggcggcgaa gagagtgcag gggcttcctt cctgcgtttc    1200

gacggcacgc cgtggtccac cgacaaagac ggcatcatca tgtgtctgct ggcggcggaa    1260

atcaccgctg tcaccggtaa gaacccgcag gaacactaca acgaactggc aaaacgcttt    1320

ggtgcgccga gctacaaccg tttgcaggca gctgcgactt ccgcacaaaa agcggcgctg    1380

tctaagctgt ctccggaaat ggtgagcgcc agcaccctgg caggtgaccc gatcaccgcg    1440

cgcctgactg ctgctccggg caacggtgct tctattggcg gtctgaaagt gatgactgac    1500

aacggctggt tcgccgcgcg tccgtcaggc acggaagatg catataagat ctactgcgaa    1560

agtttcctcg gtgaagaaca tcgcaagcag attgagaaag aagcggttga gattgttagc    1620

gaagttctga aaaacgcgta a                                              1641


<210> 7
<211> 302
<212> PRT
<213> Escherichia coli


<400> 7
Met Ala Ala Ile Asn Thr Lys Val Lys Lys Ala Val Ile Pro Val Ala 
1               5                   10                  15      
Gly Leu Gly Thr Arg Met Leu Pro Ala Thr Lys Ala Ile Pro Lys Glu 
            20                  25                  30          
Met Leu Pro Leu Val Asp Lys Pro Leu Ile Gln Tyr Val Val Asn Glu 
        35                  40                  45              
Cys Ile Ala Ala Gly Ile Thr Glu Ile Val Leu Val Thr His Ser Ser 
    50                  55                  60                  
Lys Asn Ser Ile Glu Asn His Phe Asp Thr Ser Phe Glu Leu Glu Ala 
65                  70                  75                  80  
Met Leu Glu Lys Arg Val Lys Arg Gln Leu Leu Asp Glu Val Gln Ser 
                85                  90                  95      
Ile Cys Pro Pro His Val Thr Ile Met Gln Val Arg Gln Gly Leu Ala 
            100                 105                 110         
Lys Gly Leu Gly His Ala Val Leu Cys Ala His Pro Val Val Gly Asp 
        115                 120                 125             
Glu Pro Val Ala Val Ile Leu Pro Asp Val Ile Leu Asp Glu Tyr Glu 
    130                 135                 140                 
Ser Asp Leu Ser Gln Asp Asn Leu Ala Glu Met Ile Arg Arg Phe Asp 
145                 150                 155                 160 
Glu Thr Gly His Ser Gln Ile Met Val Glu Pro Val Ala Asp Val Thr 
                165                 170                 175     
Ala Tyr Gly Val Val Asp Cys Lys Gly Val Glu Leu Ala Pro Gly Glu 
            180                 185                 190         
Ser Val Pro Met Val Gly Val Val Glu Lys Pro Lys Ala Asp Val Ala 
        195                 200                 205             
Pro Ser Asn Leu Ala Ile Val Gly Arg Tyr Val Leu Ser Ala Asp Ile 
    210                 215                 220                 
Trp Pro Leu Leu Ala Lys Thr Pro Pro Gly Ala Gly Asp Glu Ile Gln 
225                 230                 235                 240 
Leu Thr Asp Ala Ile Asp Met Leu Ile Glu Lys Glu Thr Val Glu Ala 
                245                 250                 255     
Tyr His Met Lys Gly Lys Ser His Asp Cys Gly Asn Lys Leu Gly Tyr 
            260                 265                 270         
Met Gln Ala Phe Val Glu Tyr Gly Ile Arg His Asn Thr Leu Gly Thr 
        275                 280                 285             
Glu Phe Lys Ala Trp Leu Glu Glu Glu Met Gly Ile Lys Lys 
    290                 295                 300         

<210> 8
<211> 909
<212> DNA
<213> Escherichia coli


<400> 8
atggctgcca ttaatacgaa agtcaaaaaa gccgttatcc ccgttgcggg attaggaacc      60

aggatgttgc cggcgacgaa agccatcccg aaagagatgc tgccacttgt cgataagcca     120

ttaattcaat acgtcgtgaa tgaatgtatt gcggctggca ttactgaaat tgtgctggtt     180

acacactcat ctaaaaactc tattgaaaac cactttgata ccagttttga actggaagca     240

atgctggaaa aacgtgtaaa acgtcaactg cttgatgaag tgcagtctat ttgtccaccg     300

cacgtgacta ttatgcaagt tcgtcagggt ctggcgaaag gcctgggaca cgcggtattg     360

tgtgctcacc cggtagtggg tgatgaaccg gtagctgtta ttttgcctga tgttattctg     420

gatgaatatg aatccgattt gtcacaggat aacctggcag agatgatccg ccgctttgat     480

gaaacgggtc atagccagat catggttgaa ccggttgctg atgtgaccgc atatggcgtt     540

gtggattgca aaggcgttga attagcgccg ggtgaaagcg taccgatggt tggtgtggta     600

gaaaaaccga aagcggatgt tgcgccgtct aatctcgcta ttgtgggtcg ttacgtactt     660

agcgcggata tttggccgtt gctggcaaaa acccctccgg gagctggtga tgaaattcag     720

ctcaccgacg caattgatat gctgatcgaa aaagaaacgg tggaagccta tcatatgaaa     780

gggaagagcc atgactgcgg taataaatta ggttacatgc aggccttcgt tgaatacggt     840

attcgtcata acacccttgg cacggaattt aaagcctggc ttgaagaaga gatgggcatt     900

aagaagtaa                                                             909


<210> 9
<211> 909
<212> DNA
<213> Artificial Sequence


<220> 
<223> Secuencia de nucleótidos que codifica GalU optimizada para su
      expresion en S. elongatus.

<400> 9
atggctgcca ttaatacgaa agtcaaaaaa gccgttatcc ccgttgcggg attgggaacc      60

cggatgttgc cggcgacgaa agccatcccg aaagagatgc tgccactggt cgataagcca     120

ttgattcaat acgtcgtgaa tgaatgtatt gcggctggca ttactgaaat tgtgctggtt     180

acacactcat cgaaaaactc tattgaaaac cactttgata ccagttttga actggaagca     240

atgctggaaa aacgcgtaaa acgtcaactg cttgatgaag tgcagtcgat ttgtccaccg     300

cacgtgacta ttatgcaagt tcgccagggt ctggcgaaag gcctgggaca cgcggtgttg     360

tgtgctcacc cggtcgtggg tgatgaaccg gtggctgtta ttttgcctga tgttattctg     420

gatgaatatg aatccgattt gtcacaggat aacctggcag agatgatccg ccgctttgat     480

gaaacgggtc atagccagat catggttgaa ccggttgctg atgtgaccgc atatggcgtt     540

gtggattgca aaggcgttga attagcgccg ggtgaaagcg tgccgatggt tggtgtggtc     600

gaaaaaccga aagcggatgt tgcgccgtct aatctcgcta ttgtgggtcg ttacgtactc     660

agcgcggata tttggccgtt gctggcaaaa acccctccgg gagctggtga tgaaattcag     720

ctcaccgacg caattgatat gctgatcgaa aaagaaacgg tggaagccta tcatatgaaa     780

gggaagagcc atgactgcgg taataaatta ggttacatgc aggccttcgt tgaatacggt     840

attcgtcata acacccttgg cacggaattt aaagcctggc ttgaagaaga gatgggcatt     900

aagaagtaa                                                             909


<210> 10
<211> 709
<212> PRT
<213> Synechococcus elongatus


<400> 10
Met Ala Ala Gln Asn Leu Tyr Ile Leu His Ile Gln Thr His Gly Leu 
1               5                   10                  15      
Leu Arg Gly Gln Asn Leu Glu Leu Gly Arg Asp Ala Asp Thr Gly Gly 
            20                  25                  30          
Gln Thr Lys Tyr Val Leu Glu Leu Ala Gln Ala Gln Ala Lys Ser Pro 
        35                  40                  45              
Gln Val Gln Gln Val Asp Ile Ile Thr Arg Gln Ile Thr Asp Pro Arg 
    50                  55                  60                  
Val Ser Val Gly Tyr Ser Gln Ala Ile Glu Pro Phe Ala Pro Lys Gly 
65                  70                  75                  80  
Arg Ile Val Arg Leu Pro Phe Gly Pro Lys Arg Tyr Leu Arg Lys Glu 
                85                  90                  95      
Leu Leu Trp Pro His Leu Tyr Thr Phe Ala Asp Ala Ile Leu Gln Tyr 
            100                 105                 110         
Leu Ala Gln Gln Lys Arg Thr Pro Thr Trp Ile Gln Ala His Tyr Ala 
        115                 120                 125             
Asp Ala Gly Gln Val Gly Ser Leu Leu Ser Arg Trp Leu Asn Val Pro 
    130                 135                 140                 
Leu Ile Phe Thr Gly His Ser Leu Gly Arg Ile Lys Leu Lys Lys Leu 
145                 150                 155                 160 
Leu Glu Gln Asp Trp Pro Leu Glu Glu Ile Glu Ala Gln Phe Asn Ile 
                165                 170                 175     
Gln Gln Arg Ile Asp Ala Glu Glu Met Thr Leu Thr His Ala Asp Trp 
            180                 185                 190         
Ile Val Ala Ser Thr Gln Gln Glu Val Glu Glu Gln Tyr Arg Val Tyr 
        195                 200                 205             
Asp Arg Tyr Asn Pro Glu Arg Lys Leu Val Ile Pro Pro Gly Val Asp 
    210                 215                 220                 
Thr Asp Arg Phe Arg Phe Gln Pro Leu Gly Asp Arg Gly Val Val Leu 
225                 230                 235                 240 
Gln Gln Glu Leu Ser Arg Phe Leu Arg Asp Pro Glu Lys Pro Gln Ile 
                245                 250                 255     
Leu Cys Leu Cys Arg Pro Ala Pro Arg Lys Asn Val Pro Ala Leu Val 
            260                 265                 270         
Arg Ala Phe Gly Glu His Pro Trp Leu Arg Lys Lys Ala Asn Leu Val 
        275                 280                 285             
Leu Val Leu Gly Ser Arg Gln Asp Ile Asn Gln Met Asp Arg Gly Ser 
    290                 295                 300                 
Arg Gln Val Phe Gln Glu Ile Phe His Leu Val Asp Arg Tyr Asp Leu 
305                 310                 315                 320 
Tyr Gly Ser Val Ala Tyr Pro Lys Gln His Gln Ala Asp Asp Val Pro 
                325                 330                 335     
Glu Phe Tyr Arg Leu Ala Ala His Ser Gly Gly Val Phe Val Asn Pro 
            340                 345                 350         
Ala Leu Thr Glu Pro Phe Gly Leu Thr Ile Leu Glu Ala Gly Ser Cys 
        355                 360                 365             
Gly Val Pro Val Val Ala Thr His Asp Gly Gly Pro Gln Glu Ile Leu 
    370                 375                 380                 
Lys His Cys Asp Phe Gly Thr Leu Val Asp Val Ser Arg Pro Ala Asn 
385                 390                 395                 400 
Ile Ala Thr Ala Leu Ala Thr Leu Leu Ser Asp Arg Asp Leu Trp Gln 
                405                 410                 415     
Cys Tyr His Arg Asn Gly Ile Glu Lys Val Pro Ala His Tyr Ser Trp 
            420                 425                 430         
Asp Gln His Val Asn Thr Leu Phe Glu Arg Met Glu Thr Val Ala Leu 
        435                 440                 445             
Pro Arg Arg Arg Ala Val Ser Phe Val Arg Ser Arg Lys Arg Leu Ile 
    450                 455                 460                 
Asp Ala Lys Arg Leu Val Val Ser Asp Ile Asp Asn Thr Leu Leu Gly 
465                 470                 475                 480 
Asp Arg Gln Gly Leu Glu Asn Leu Met Thr Tyr Leu Asp Gln Tyr Arg 
                485                 490                 495     
Asp His Phe Ala Phe Gly Ile Ala Thr Gly Arg Arg Leu Asp Ser Ala 
            500                 505                 510         
Gln Glu Val Leu Lys Glu Trp Gly Val Pro Ser Pro Asn Phe Trp Val 
        515                 520                 525             
Thr Ser Val Gly Ser Glu Ile His Tyr Gly Thr Asp Ala Glu Pro Asp 
    530                 535                 540                 
Ile Ser Trp Glu Lys His Ile Asn Arg Asn Trp Asn Pro Gln Arg Ile 
545                 550                 555                 560 
Arg Ala Val Met Ala Gln Leu Pro Phe Leu Glu Leu Gln Pro Glu Glu 
                565                 570                 575     
Asp Gln Thr Pro Phe Lys Val Ser Phe Phe Val Arg Asp Arg His Glu 
            580                 585                 590         
Thr Val Leu Arg Glu Val Arg Gln His Leu Arg Arg His Arg Leu Arg 
        595                 600                 605             
Leu Lys Ser Ile Tyr Ser His Gln Glu Phe Leu Asp Ile Leu Pro Leu 
    610                 615                 620                 
Ala Ala Ser Lys Gly Asp Ala Ile Arg His Leu Ser Leu Arg Trp Arg 
625                 630                 635                 640 
Ile Pro Leu Glu Asn Ile Leu Val Ala Gly Asp Ser Gly Asn Asp Glu 
                645                 650                 655     
Glu Met Leu Lys Gly His Asn Leu Gly Val Val Val Gly Asn Tyr Ser 
            660                 665                 670         
Pro Glu Leu Glu Pro Leu Arg Ser Tyr Glu Arg Val Tyr Phe Ala Glu 
        675                 680                 685             
Gly His Tyr Ala Asn Gly Ile Leu Glu Ala Leu Lys His Tyr Arg Phe 
    690                 695                 700                 
Phe Glu Ala Ile Ala 
705                 

<210> 11
<211> 2130
<212> DNA
<213> Synechococcus elongatus


<400> 11
gtggcagctc aaaatctcta cattctgcac attcagaccc atggtctgct gcgagggcag      60

aacttggaac tggggcgaga tgccgacacc ggcgggcaga ccaagtacgt cttagaactg     120

gctcaagccc aagctaaatc cccacaagtc caacaagtcg acatcatcac ccgccaaatc     180

accgaccccc gcgtcagtgt tggttacagt caggcgatcg aaccctttgc gcccaaaggt     240

cggattgtcc gtttgccttt tggccccaaa cgctacctcc gtaaagagct gctttggccc     300

catctctaca cctttgcgga tgcaattctc caatatctgg ctcagcaaaa gcgcaccccg     360

acttggattc aggcccacta tgctgatgct ggccaagtgg gatcactgct gagtcgctgg     420

ttgaatgtac cgctaatttt cacagggcat tctctggggc ggatcaagct aaaaaagctg     480

ttggagcaag actggccgct tgaggaaatt gaagcgcaat tcaatattca acagcgaatt     540

gatgcggagg agatgacgct cactcatgct gactggattg tcgccagcac tcagcaggaa     600

gtggaggagc aataccgcgt ttacgatcgc tacaacccag agcgcaagct tgtcattcca     660

ccgggtgtcg ataccgatcg cttcaggttt cagcccttgg gcgatcgcgg tgttgttctc     720

caacaggaac tgagccgctt tctgcgcgac ccagaaaaac ctcaaattct ctgcctctgt     780

cgccccgcac ctcgcaaaaa tgtaccggcg ctggtgcgag cctttggcga acatccttgg     840

ctgcgcaaaa aagccaacct tgtcttagta ctgggcagcc gccaagacat caaccagatg     900

gatcgcggca gtcggcaggt gttccaagag attttccatc tggtcgatcg ctacgacctc     960

tacggcagcg tcgcctatcc caaacagcat caggctgatg atgtgccgga gttctatcgc    1020

ctagcggctc attccggcgg ggtattcgtc aatccggcgc tgaccgaacc ttttggtttg    1080

acaattttgg aggcaggaag ctgcggcgtg ccggtggtgg caacccatga tggcggcccc    1140

caggaaattc tcaaacactg tgatttcggc actttagttg atgtcagccg acccgctaat    1200

atcgcgactg cactcgccac cctgctgagc gatcgcgatc tttggcagtg ctatcaccgc    1260

aatggcattg aaaaagttcc cgcccattac agctgggatc aacatgtcaa taccctgttt    1320

gagcgcatgg aaacggtggc tttgcctcgt cgtcgtgctg tcagtttcgt acggagtcgc    1380

aaacgcttga ttgatgccaa acgccttgtc gttagtgaca tcgacaacac actgttgggc    1440

gatcgtcaag gactcgagaa tttaatgacc tatctcgatc agtatcgcga tcattttgcc    1500

tttggaattg ccacggggcg tcgcctagac tctgcccaag aagtcttgaa agagtggggc    1560

gttccttcgc caaacttctg ggtgacttcc gtcggcagcg agattcacta tggcaccgat    1620

gctgaaccgg atatcagctg ggaaaagcat atcaatcgca actggaatcc tcagcgaatt    1680

cgggcagtaa tggcacaact accctttctt gaactgcagc cggaagagga tcaaacaccc    1740

ttcaaagtca gcttctttgt ccgcgatcgc cacgagactg tgctgcgaga agtacggcaa    1800

catcttcgcc gccatcgcct gcggctgaag tcaatctatt cccatcagga gtttcttgac    1860

attctgccgc tagctgcctc gaaaggggat gcgattcgcc acctctcact ccgctggcgg    1920

attcctcttg agaacatttt ggtggcaggc gattctggta acgatgagga aatgctcaag    1980

ggccataatc tcggcgttgt agttggcaat tactcaccgg aattggagcc actgcgcagc    2040

tacgagcgcg tctattttgc tgagggccac tatgctaatg gcattctgga agccttaaaa    2100

cactatcgct tttttgaggc gatcgcttaa                                     2130


<210> 12
<211> 2130
<212> DNA
<213> Artificial Sequence


<220> 
<223> Secuencia de nucleótidos que codifica SPS optimizada

<400> 12
atggcagctc aaaatctcta cattctgcac attcagaccc atggtctgct gcgagggcag      60

aacttggaac tggggcgaga tgccgacacc ggcgggcaga ccaagtacgt cttagaactg     120

gctcaagccc aagctaaatc cccacaagtc caacaagtcg atatcatcac ccgccaaatc     180

accgaccccc gcgtcagtgt tggttacagt caggcgatcg aaccctttgc gcccaaaggt     240

cggattgtcc gtttgccttt tggccccaaa cgctacctcc gtaaagagct gctttggccc     300

catctctaca cctttgcgga tgcaattctc caatatctgg ctcagcaaaa gcgcaccccg     360

acttggattc aggcccacta tgctgatgct ggccaagtgg gatcactgct gagtcgctgg     420

ttgaatgtac cgctaatttt cacagggcat tctctggggc ggatcaagct aaaaaagctg     480

ttggagcaag actggccgct tgaggaaatt gaagcgcaat tcaatattca acagcgaatt     540

gatgcggagg agatgacgct cactcatgct gactggattg tcgccagcac tcagcaggaa     600

gtggaggagc aataccgcgt ttacgatcgc tacaacccag agcgcaagct ggtcattcca     660

ccgggtgtcg ataccgatcg cttcaggttt cagcccttgg gcgatcgcgg tgttgttctc     720

caacaggaac tgagccgctt tctgcgcgac ccagaaaaac ctcaaattct ctgcctctgt     780

cgccccgcac ctcgcaaaaa tgtaccggcg ctggtgcgag cctttggcga acatccttgg     840

ctgcgcaaaa aagccaacct tgtcttagta ctgggcagcc gccaagacat caaccagatg     900

gatcgcggca gtcggcaggt gttccaagag attttccatc tggtcgatcg ctacgacctc     960

tacggcagcg tcgcctatcc caaacagcat caggctgatg atgtgccgga gttctatcgc    1020

ctagcggctc attccggcgg ggtattcgtc aatccggcgc tgaccgaacc ttttggtttg    1080

acaattttgg aggcaggaag ctgcggcgtg ccggtggtgg caacccatga tggcggcccc    1140

caggaaattc tcaaacactg tgatttcggc actttagttg atgtcagccg acccgctaat    1200

atcgcgactg cactcgccac cctgctgagc gatcgcgatc tttggcagtg ctatcaccgc    1260

aatggcattg aaaaagttcc cgcccattac agctgggatc aacatgtcaa taccctgttt    1320

gagcgcatgg aaacggtggc tttgcctcgt cgtcgtgctg tcagtttcgt acggagtcgc    1380

aaacgcttga ttgatgccaa acgccttgtc gttagtgaca tcgacaacac actgttgggc    1440

gatcgtcaag gactcgaaaa tttaatgacc tatctcgatc agtatcgcga tcattttgcc    1500

tttggaattg ccacggggcg tcgcctagac tctgcccaag aagtcttgaa agagtggggc    1560

gttccttcgc caaacttctg ggtgacttcc gtcggcagcg agattcacta tggcaccgat    1620

gctgaaccgg atatcagctg ggaaaagcat atcaatcgca actggaatcc tcagcgcatt    1680

cgggcagtaa tggcacaact accctttctt gaactgcaac cggaagagga tcaaacaccc    1740

ttcaaagtca gcttctttgt ccgcgatcgc cacgagactg tgctgcgaga agtacggcaa    1800

catcttcgcc gccatcgcct gcggctgaag tcaatctatt cccatcagga gtttcttgac    1860

attctgccgc tggctgcctc gaaaggggat gcgattcgcc acctctcact ccgctggcgg    1920

attcctcttg agaacatttt ggtggcaggc gattctggta acgatgagga aatgctcaag    1980

ggccataatc tcggcgttgt agttggcaat tactcaccgg aattggagcc actgcgcagc    2040

tacgagcgcg tctattttgc tgagggccac tatgctaatg gcattctgga agccttaaaa    2100

cactatcgct tttttgaggc gatcgcttaa                                     2130


<210> 13
<211> 415
<212> PRT
<213> Escherichia coli


<400> 13
Met Ala Leu Asn Ile Pro Phe Arg Asn Ala Tyr Tyr Arg Phe Ala Ser 
1               5                   10                  15      
Ser Tyr Ser Phe Leu Phe Phe Ile Ser Trp Ser Leu Trp Trp Ser Leu 
            20                  25                  30          
Tyr Ala Ile Trp Leu Lys Gly His Leu Gly Leu Thr Gly Thr Glu Leu 
        35                  40                  45              
Gly Thr Leu Tyr Ser Val Asn Gln Phe Thr Ser Ile Leu Phe Met Met 
    50                  55                  60                  
Phe Tyr Gly Ile Val Gln Asp Lys Leu Gly Leu Lys Lys Pro Leu Ile 
65                  70                  75                  80  
Trp Cys Met Ser Phe Ile Leu Val Leu Thr Gly Pro Phe Met Ile Tyr 
                85                  90                  95      
Val Tyr Glu Pro Leu Leu Gln Ser Asn Phe Ser Val Gly Leu Ile Leu 
            100                 105                 110         
Gly Ala Leu Phe Phe Gly Leu Gly Tyr Leu Ala Gly Cys Gly Leu Leu 
        115                 120                 125             
Asp Ser Phe Thr Glu Lys Met Ala Arg Asn Phe His Phe Glu Tyr Gly 
    130                 135                 140                 
Thr Ala Arg Ala Trp Gly Ser Phe Gly Tyr Ala Ile Gly Ala Phe Phe 
145                 150                 155                 160 
Ala Gly Ile Phe Phe Ser Ile Ser Pro His Ile Asn Phe Trp Leu Val 
                165                 170                 175     
Ser Leu Phe Gly Ala Val Phe Met Met Ile Asn Met Arg Phe Lys Asp 
            180                 185                 190         
Lys Asp His Gln Cys Val Ala Ala Asp Ala Gly Gly Val Lys Lys Glu 
        195                 200                 205             
Asp Phe Ile Ala Val Phe Lys Asp Arg Asn Phe Trp Val Phe Val Ile 
    210                 215                 220                 
Phe Ile Val Gly Thr Trp Ser Phe Tyr Asn Ile Phe Asp Gln Gln Leu 
225                 230                 235                 240 
Phe Pro Val Phe Tyr Ser Gly Leu Phe Glu Ser His Asp Val Gly Thr 
                245                 250                 255     
Arg Leu Tyr Gly Tyr Leu Asn Ser Phe Gln Val Val Leu Glu Ala Leu 
            260                 265                 270         
Cys Met Ala Ile Ile Pro Phe Phe Val Asn Arg Val Gly Pro Lys Asn 
        275                 280                 285             
Ala Leu Leu Ile Gly Val Val Ile Met Ala Leu Arg Ile Leu Ser Cys 
    290                 295                 300                 
Ala Leu Phe Val Asn Pro Trp Ile Ile Ser Leu Val Lys Leu Leu His 
305                 310                 315                 320 
Ala Ile Glu Val Pro Leu Cys Val Ile Ser Val Phe Lys Tyr Ser Val 
                325                 330                 335     
Ala Asn Phe Asp Lys Arg Leu Ser Ser Thr Ile Phe Leu Ile Gly Phe 
            340                 345                 350         
Gln Ile Ala Ser Ser Leu Gly Ile Val Leu Leu Ser Thr Pro Thr Gly 
        355                 360                 365             
Ile Leu Phe Asp His Ala Gly Tyr Gln Thr Val Phe Phe Ala Ile Ser 
    370                 375                 380                 
Gly Ile Val Cys Leu Met Leu Leu Phe Gly Ile Phe Phe Leu Ser Lys 
385                 390                 395                 400 
Lys Arg Glu Gln Ile Val Met Glu Thr Pro Val Pro Ser Ala Ile 
                405                 410                 415 

<210> 14
<211> 1248
<212> DNA
<213> Escherichia coli


<400> 14
atggcactga atattccatt cagaaatgcg tactatcgtt ttgcatccag ttactcattt      60

ctctttttta tttcctggtc gctgtggtgg tcgttatacg ctatttggct gaaaggacat     120

ctagggttga cagggacgga attaggtaca ctttattcgg tcaaccagtt taccagcatt     180

ctatttatga tgttctacgg catcgttcag gataaactcg gtctgaagaa accgctcatc     240

tggtgtatga gtttcatcct ggtcttgacc ggaccgttta tgatttacgt ttatgaaccg     300

ttactgcaaa gcaatttttc tgtaggtcta attctggggg cgctattttt tggcttgggg     360

tatctggcgg gatgcggttt gcttgatagc ttcaccgaaa aaatggcgcg aaattttcat     420

ttcgaatatg gaacagcgcg cgcctgggga tcttttggct atgctattgg cgcgttcttt     480

gccggcatat tttttagtat cagtccccat atcaacttct ggttggtctc gctatttggc     540

gctgtattta tgatgatcaa catgcgtttt aaagataagg atcaccagtg cgtagcggca     600

gatgcgggag gggtaaaaaa agaggatttt atcgcagttt tcaaggatcg aaacttctgg     660

gttttcgtca tatttattgt ggggacgtgg tctttctata acatttttga tcaacaactt     720

tttcctgtct tttattcagg tttattcgaa tcacacgatg taggaacgcg cctgtatggt     780

tatctcaact cattccaggt ggtactcgaa gcgctgtgca tggcgattat tcctttcttt     840

gtgaatcggg tagggccaaa aaatgcatta cttatcggag ttgtgattat ggcgttgcgt     900

atcctttcct gcgcgctgtt cgttaacccc tggattattt cattagtgaa gttgttacat     960

gccattgagg ttccactttg tgtcatatcc gtcttcaaat acagcgtggc aaactttgat    1020

aagcgcctgt cgtcgacgat ctttctgatt ggttttcaaa ttgccagttc gcttgggatt    1080

gtgctgcttt caacgccgac tgggatactc tttgaccacg caggctacca gacagttttc    1140

ttcgcaattt cgggtattgt ctgcctgatg ttgctatttg gcattttctt cttgagtaaa    1200

aaacgcgagc aaatagttat ggaaacgcct gtaccttcag caatatag                 1248


<210> 15
<211> 1248
<212> DNA
<213> Artificial Sequence


<220> 
<223> Secuencia de nucleótidos que codifica la proteína CSCB optimizada
      para su expresión en S. elongatus.

<400> 15
atggcactga atattccatt ccgaaatgcg tactatcgtt ttgcatccag ttactcgttt      60

ctctttttta tttcctggtc gctgtggtgg tcgttgtacg ctatttggct gaaaggacat     120

ctagggttga cagggacgga attaggtaca ctgtattcgg tcaaccagtt taccagcatt     180

ctatttatga tgttctacgg catcgttcag gataaactcg gtctgaagaa accgctcatc     240

tggtgtatga gtttcatcct ggtcttgacc ggaccgttta tgatttacgt ttatgaaccg     300

ttgctgcaaa gcaatttttc tgtgggtcta attctggggg cgctattttt tggcttgggg     360

tatctggcgg gatgcggttt gcttgatagc ttcaccgaaa aaatggcgcg aaattttcat     420

ttcgaatatg gaacagcgcg cgcctgggga tcttttggct atgctattgg cgcgttcttt     480

gccggcatct tttttagtat cagtccccat atcaacttct ggttggtgtc gctatttggc     540

gctgtattta tgatgatcaa catgcgtttt aaagataagg atcaccagtg cgtagcggca     600

gatgcgggag gggtcaaaaa agaggatttt atcgcagttt tcaaggatcg aaacttctgg     660

gttttcgtca tctttattgt ggggacgtgg tctttctata acatttttga tcaacaactg     720

tttcctgtct tttattcagg tttattcgaa tcgcacgatg taggaacgcg cctgtatggt     780

tatctcaact cattccaggt ggtcctcgaa gcgctgtgca tggcgattat tcctttcttt     840

gtgaatcggg tggggccaaa aaatgcatta cttatcggag ttgtgattat ggcgttgcgt     900

atcctgtcct gcgcgctgtt cgttaacccc tggattattt cattggtgaa gttgttacat     960

gccattgagg ttccactttg tgtcatctcc gtgttcaaat acagcgtggc aaactttgat    1020

aagcgcctgt cgtccacgat ctttctgatt ggttttcaaa ttgccagttc gcttgggatt    1080

gtgctgcttt cgacgccgac tgggattctc tttgaccacg caggctacca gacagttttc    1140

ttcgcaattt cgggtattgt ctgcctgatg ttgctatttg gcattttctt cttgagtaaa    1200

aaacgcgagc aaatcgttat ggaaacgcct gtaccttcag caatctag                 1248


<210> 16
<211> 360
<212> PRT
<213> Escherichia coli


<400> 16
Met Lys Pro Val Thr Leu Tyr Asp Val Ala Glu Tyr Ala Gly Val Ser 
1               5                   10                  15      
Tyr Gln Thr Val Ser Arg Val Val Asn Gln Ala Ser His Val Ser Ala 
            20                  25                  30          
Lys Thr Arg Glu Lys Val Glu Ala Ala Met Ala Glu Leu Asn Tyr Ile 
        35                  40                  45              
Pro Asn Arg Val Ala Gln Gln Leu Ala Gly Lys Gln Ser Leu Leu Ile 
    50                  55                  60                  
Gly Val Ala Thr Ser Ser Leu Ala Leu His Ala Pro Ser Gln Ile Val 
65                  70                  75                  80  
Ala Ala Ile Lys Ser Arg Ala Asp Gln Leu Gly Ala Ser Val Val Val 
                85                  90                  95      
Ser Met Val Glu Arg Ser Gly Val Glu Ala Cys Lys Ala Ala Val His 
            100                 105                 110         
Asn Leu Leu Ala Gln Arg Val Ser Gly Leu Ile Ile Asn Tyr Pro Leu 
        115                 120                 125             
Asp Asp Gln Asp Ala Ile Ala Val Glu Ala Ala Cys Thr Asn Val Pro 
    130                 135                 140                 
Ala Leu Phe Leu Asp Val Ser Asp Gln Thr Pro Ile Asn Ser Ile Ile 
145                 150                 155                 160 
Phe Ser His Glu Asp Gly Thr Arg Leu Gly Val Glu His Leu Val Ala 
                165                 170                 175     
Leu Gly His Gln Gln Ile Ala Leu Leu Ala Gly Pro Leu Ser Ser Val 
            180                 185                 190         
Ser Ala Arg Leu Arg Leu Ala Gly Trp His Lys Tyr Leu Thr Arg Asn 
        195                 200                 205             
Gln Ile Gln Pro Ile Ala Glu Arg Glu Gly Asp Trp Ser Ala Met Ser 
    210                 215                 220                 
Gly Phe Gln Gln Thr Met Gln Met Leu Asn Glu Gly Ile Val Pro Thr 
225                 230                 235                 240 
Ala Met Leu Val Ala Asn Asp Gln Met Ala Leu Gly Ala Met Arg Ala 
                245                 250                 255     
Ile Thr Glu Ser Gly Leu Arg Val Gly Ala Asp Ile Ser Val Val Gly 
            260                 265                 270         
Tyr Asp Asp Thr Glu Asp Ser Ser Cys Tyr Ile Pro Pro Leu Thr Thr 
        275                 280                 285             
Ile Lys Gln Asp Phe Arg Leu Leu Gly Gln Thr Ser Val Asp Arg Leu 
    290                 295                 300                 
Leu Gln Leu Ser Gln Gly Gln Ala Val Lys Gly Asn Gln Leu Leu Pro 
305                 310                 315                 320 
Val Ser Leu Val Lys Arg Lys Thr Thr Leu Ala Pro Asn Thr Gln Thr 
                325                 330                 335     
Ala Ser Pro Arg Ala Leu Ala Asp Ser Leu Met Gln Leu Ala Arg Gln 
            340                 345                 350         
Val Ser Arg Leu Glu Ser Gly Gln 
        355                 360 

<210> 17
<211> 1083
<212> DNA
<213> Escherichia coli


<400> 17
gtgaaaccag taacgttata cgatgtcgca gagtatgccg gtgtctctta tcagaccgtt      60

tcccgcgtgg tgaaccaggc cagccacgtt tctgcgaaaa cgcgggaaaa agtggaagcg     120

gcgatggcgg agctgaatta cattcccaac cgcgtggcac aacaactggc gggcaaacag     180

tcgttgctga ttggcgttgc cacctccagt ctggccctgc acgcgccgtc gcaaattgtc     240

gcggcgatta aatctcgcgc cgatcaactg ggtgccagcg tggtggtgtc gatggtagaa     300

cgaagcggcg tcgaagcctg taaagcggcg gtgcacaatc ttctcgcgca acgcgtcagt     360

gggctgatca ttaactatcc gctggatgac caggatgcca ttgctgtgga agctgcctgc     420

actaatgttc cggcgttatt tcttgatgtc tctgaccaga cacccatcaa cagtattatt     480

ttctcccatg aagacggtac gcgactgggc gtggagcatc tggtcgcatt gggtcaccag     540

caaatcgcgc tgttagcggg cccattaagt tctgtctcgg cgcgtctgcg tctggctggc     600

tggcataaat atctcactcg caatcaaatt cagccgatag cggaacggga aggcgactgg     660

agtgccatgt ccggttttca acaaaccatg caaatgctga atgagggcat cgttcccact     720

gcgatgctgg ttgccaacga tcagatggcg ctgggcgcaa tgcgcgccat taccgagtcc     780

gggctgcgcg ttggtgcgga tatctcggta gtgggatacg acgataccga agacagctca     840

tgttatatcc cgccgttaac caccatcaaa caggattttc gcctgctggg gcaaaccagc     900

gtggaccgct tgctgcaact ctctcagggc caggcggtga agggcaatca gctgttgccc     960

gtctcactgg tgaaaagaaa aaccaccctg gcgcccaata cgcaaaccgc ctctccccgc    1020

gcgttggccg attcattaat gcagctggca cgacaggttt cccgactgga aagcgggcag    1080

tga                                                                  1083


<210> 18
<211> 1083
<212> DNA
<213> Artificial Sequence


<220> 
<223> Secuencia de nucleótidos que codifica la proteína LacI optimizada
      para su expresión en S. elongatus.

<400> 18
atgaaaccag tgacgttgta cgatgtcgca gagtatgccg gtgtctcgta tcagaccgtt      60

tcccgcgtgg tgaaccaggc cagccacgtt tctgcgaaaa cgcgggaaaa agtggaagcg     120

gcgatggcgg agctgaatta cattcccaac cgcgtggcac aacaactggc gggcaaacag     180

tcgttgctga ttggcgttgc cacctccagt ctggccctgc acgcgccgtc gcaaattgtc     240

gcggcgatta aatcgcgcgc cgatcaactg ggtgccagcg tggtggtgtc gatggtggaa     300

cgaagcggcg tcgaagcctg taaagcggcg gtgcacaatc ttctcgcgca acgcgtcagt     360

gggctgatca ttaactatcc gctggatgac caggatgcca ttgctgtgga agctgcctgc     420

actaatgttc cggcgttgtt tcttgatgtc tcggaccaga cacccatcaa cagtattatt     480

ttctcccatg aggacggtac gcgactgggc gtggagcatc tggtcgcatt gggtcaccag     540

caaatcgcgc tgttggcggg cccattaagt tctgtctcgg cgcgcctgcg tctggctggc     600

tggcataaat atctcactcg caatcaaatt cagccgatcg cggaacggga aggcgactgg     660

agtgccatgt ccggttttca acaaaccatg caaatgctga atgagggcat cgttcccact     720

gcgatgctgg ttgccaacga tcagatggcg ctgggcgcaa tgcgcgccat taccgagtcc     780

gggctgcgcg ttggtgcgga tatctcggta gtgggatacg acgataccga agatagctca     840

tgttatatcc cgccgttaac caccatcaaa caggattttc gcctgctggg gcaaaccagc     900

gtggaccgct tgctgcaact ctcgcagggc caggcggtga agggcaatca gctgttgccc     960

gtctcactgg tgaaacgaaa aaccaccctg gcgcccaata cgcaaaccgc ctctccccgc    1020

gcgttggccg attcgttaat gcagctggca cgacaggttt cccgactgga aagcgggcag    1080

tga                                                                  1083


<210> 19
<211> 5376
<212> DNA
<213> Artificial Sequence


<220> 
<223> Secuencia de nucleótidos del Operón "A

<400> 19
aggagctcca ccgatcaagc ttttgacata agcctgttcg gttcgtaaac tgtaatgcaa       60

gtagcgtatg cgctcacgca actggtccag aaccttgacc gaacgcagcg gtggtaacgg      120

cgcagtggcg gttttcatgg cttgttatga ctgttttttt gtacagtcta tgcctcgggc      180

atccaagcag caagcgcgtt acgccgtggg tcgatgtttg atgttatgga gcagcaacga      240

tgttacgcag cagcaacgat gttacgcagc agggcagtcg ccctaaaaca aagttaggtg      300

gctcaagtat gggcatcatt cgcacatgta ggctcggccc tgaccaagtc aaatccatgc      360

gggctgctct tgatcttttc ggtcgtgagt tcggagacgt agccacctac tcccaacatc      420

agccggactc cgattacctc gggaacttgc tccgtagtaa gacattcatc gcgcttgctg      480

ccttcgacca agaagcggtt gttggcgctc tcgcggctta cgttctgccc aggtttgagc      540

agccgcgtag tgagatctat atctatgatc tcgcagtctc cggcgagcac cggaggcagg      600

gcattgccac cgcgctcatc aatctcctca agcatgaggc caacgcgctt ggtgcttatg      660

tgatctacgt gcaagcagat tacggtgacg atcccgcagt ggctctctat acaaagttgg      720

gcatacggga agaagtgatg cactttgata tcgacccaag taccgccacc taacaattcg      780

ttcaagccga gatcggcttc ccggccgcgg agttgttcgg taaattgtca caacgccgcg      840

gccggatccg gtaccctgaa atgagctgtt gacaattaat catccggctc gtataatgtg      900

tggaattgtg agcggataac aatttcacac tactagagta gtggaggtta ctaaatgaaa      960

aacatcaatc caacgcagac cgctgcctgg caggcactac agaaacactt cgatgaaatg     1020

aaagacgtta cgatcgccga tctttttgct aaagacggcg atcgcttttc taagttctcc     1080

gcaaccttcg acgatcagat gctggtggat tactccaaaa accgcatcac tgaagagacg     1140

ctggcgaaat tacaggatct ggcgaaagag tgcgatctgg cgggcgcgat taagtcgatg     1200

ttctcgggcg agaagatcaa ccgcactgaa aaccgcgccg tgctgcacgt ggcgctgcgt     1260

aaccgcagca ataccccgat tttggttgat ggcaaagacg tcatgccgga agtcaacgcg     1320

gtgctggaga agatgaaaac cttctcagaa gcgattattt ccggtgagtg gaaaggttat     1380

accggcaaag caatcactga cgtagtgaac atcgggatcg gcggttcgga cctcggccca     1440

tacatggtga ccgaagctct gcggccgtac aaaaaccacc tgaacatgca ctttgtttct     1500

aacgtcgatg ggactcacat cgcggaagtg ctgaaaaaag tgaacccgga aaccacgctg     1560

ttcttggtag catcgaaaac cttcaccact caggaaacta tgaccaacgc ccatagcgcg     1620

cgtgactggt tcctgaaagc ggcaggtgat gaaaaacacg ttgcaaaaca ctttgcggcg     1680

ctttccacca atgccaaagc cgttggcgag tttggtattg atactgccaa catgttcgag     1740

ttctgggact gggttggcgg ccggtactct ttgtggtcag cgattggcct gtcgattgtt     1800

ctctccatcg gctttgataa cttcgttgaa ctgctttccg gcgcacacgc gatggacaag     1860

catttctcca ccacgcctgc cgagaaaaac ctgcctgtcc tgctggcgct gattggcatc     1920

tggtacaaca atttctttgg tgcggaaact gaagcgattc tgccgtatga ccagtatatg     1980

caccgtttcg cggcgtactt ccagcagggc aatatggagt ccaacggtaa gtatgttgac     2040

cgtaacggta acgttgtgga ttaccagact ggcccgatta tctggggtga accaggcact     2100

aacggtcagc acgcgttcta ccagctgatc caccagggaa ccaaaatggt gccgtgcgat     2160

ttcatcgctc cggctatcac ccataacccg ctctctgatc atcaccagaa actgctgtcg     2220

aacttcttcg cccagaccga agcgctggcg tttggtaaat cccgcgaagt ggttgagcag     2280

gaatatcgcg atcagggtaa agatccggca acgcttgact acgtggtgcc gttcaaagta     2340

ttcgaaggta accgcccgac caactccatc ctgctgcgtg aaatcactcc gttcagcctg     2400

ggtgcgttga ttgcgctgta tgagcacaaa atctttactc agggcgtgat cctgaacatc     2460

ttcaccttcg accagtgggg cgtggaactg ggtaaacagc tggcgaaccg tattctgcca     2520

gagctgaaag atgataaaga aatcagcagc cacgatagct cgaccaatgg tctgattaac     2580

cgctataaag cgtggcgcgg ttaataaaat gagagtagtg gaggttacta aatggcaatc     2640

cacaatcgcg caggccaacc tgcacaacag agtgatttga ttaacgtcgc ccaactgacg     2700

gcgcaatatt atgtgctgaa accagaagca gggaatgcgg agcacgcggt gaaattcggt     2760

acttccggtc accggggcag tgcagcgcgc cacagcttta acgagccgca cattctggcg     2820

atcgctcagg caattgctga agaacgcgcg aaaaacggca tcactggccc ttgctatgtg     2880

ggtaaagata ctcacgccct gtccgaacct gcattcattt ccgttctgga agtgctggca     2940

gcgaacggcg ttgatgtcat tgtgcaggaa aacaatggct tcaccccgac gcctgccgtt     3000

tccaatgcca tcctggttca caataaaaaa ggtggcccgc tggcagacgg tatcgtgatt     3060

acaccgtccc ataacccgcc ggaagatggt ggaatcaaat acaatccgcc aaatggtggc     3120

ccggctgata ccaacgtcac taaagtggtg gaggaccggg ccaacgcact gctggccgat     3180

ggcctgaaag gcgtgaagcg tatctccctc gacgaagcga tggcatccgg tcatgtgaaa     3240

gagcaggatc tggtgcagcc gttcgtggaa ggtctggccg atatcgttga tatggccgcg     3300

attcagaaag cgggcctgac gctgggcgtt gatccgctgg gcggttccgg tatcgaatac     3360

tggaagcgca ttggcgagta ttacaacctc aacctgacta tcgttaacga tcaggtcgat     3420

caaaccttcc gctttatgca ccttgataaa gacggcgcga tccgtatgga ctgctcctcc     3480

gagtgtgcga tggcgggcct gctggcactg cgtgataagt tcgatctggc gtttgctaac     3540

gacccggatt atgaccgcca cggtatcgtc actccggcag gtttgatgaa tccgaaccac     3600

tacctggcgg tggcaatcaa ttacctgttc cagcatcgtc cgcagtgggg caaagatgtt     3660

gccgtcggta aaacgctggt ttcatcggcg atgatcgacc gtgtggtcaa cgacttgggc     3720

cgtaaactgg tagaagtccc ggtaggtttc aaatggtttg tcgatggtct gttcgacggc     3780

agcttcggct ttggcggcga agagagtgca ggggcttcct tcctgcgttt cgacggcacg     3840

ccgtggtcca ccgacaaaga cggcatcatc atgtgtctgc tggcggcgga aatcaccgct     3900

gtcaccggta agaacccgca ggaacactac aacgaactgg caaaacgctt tggtgcgccg     3960

agctacaacc gtttgcaggc agctgcgact tccgcacaaa aagcggcgct gtctaagctg     4020

tctccggaaa tggtgagcgc cagcaccctg gcaggtgacc cgatcaccgc gcgcctgact     4080

gctgctccgg gcaacggtgc ttctattggc ggtctgaaag tgatgactga caacggctgg     4140

ttcgccgcgc gtccgtcagg cacggaagat gcatataaga tctactgcga aagtttcctc     4200

ggtgaagaac atcgcaagca gattgagaaa gaagcggttg agattgttag cgaagttctg     4260

aaaaacgcgt aataaaggta gagtagtgga ggttactaaa tggctgccat taatacgaaa     4320

gtcaaaaaag ccgttatccc cgttgcggga ttgggaaccc ggatgttgcc ggcgacgaaa     4380

gccatcccga aagagatgct gccactggtc gataagccat tgattcaata cgtcgtgaat     4440

gaatgtattg cggctggcat tactgaaatt gtgctggtta cacactcatc gaaaaactct     4500

attgaaaacc actttgatac cagttttgaa ctggaagcaa tgctggaaaa acgcgtaaaa     4560

cgtcaactgc ttgatgaagt gcagtcgatt tgtccaccgc acgtgactat tatgcaagtt     4620

cgccagggtc tggcgaaagg cctgggacac gcggtgttgt gtgctcaccc ggtcgtgggt     4680

gatgaaccgg tggctgttat tttgcctgat gttattctgg atgaatatga atccgatttg     4740

tcacaggata acctggcaga gatgatccgc cgctttgatg aaacgggtca tagccagatc     4800

atggttgaac cggttgctga tgtgaccgca tatggcgttg tggattgcaa aggcgttgaa     4860

ttagcgccgg gtgaaagcgt gccgatggtt ggtgtggtcg aaaaaccgaa agcggatgtt     4920

gcgccgtcta atctcgctat tgtgggtcgt tacgtactca gcgcggatat ttggccgttg     4980

ctggcaaaaa cccctccggg agctggtgat gaaattcagc tcaccgacgc aattgatatg     5040

ctgatcgaaa aagaaacggt ggaagcctat catatgaaag ggaagagcca tgactgcggt     5100

aataaattag gttacatgca ggccttcgtt gaatacggta ttcgtcataa cacccttggc     5160

acggaattta aagcctggct tgaagaagag atgggcatta agaagtaata aaggtccagg     5220

catcaaataa aacgaaaggc tcagtcgaaa gactgggcct ttcgttttat ctgttgtttg     5280

tcggtgaacg ctctctacta gagtcacact ggctcacctt cgggtgggcc tttctgcgtt     5340

tatagtcgac ctcgaggggg ggcccggtac cttctg                               5376


<210> 20
<211> 6660
<212> DNA
<213> Artificial Sequence


<220> 
<223> Secuencia de nucleótidos del Operón "B

<400> 20
gatctgtttt tgttcctgca atgaccattg ctgaggagtt cccatgaaaa tcaagtcatc       60

gatttctgtg ctcgctgcga tattttcctg cttaaccgct gaaagtacgt ccatataaat      120

gcctctatta gttagcgcta tcgcgcgaaa agaatggtga tataaggggc atcgctgccc      180

cttcagcatc agttaaacgt atttaaatgg ccactagtag gtggggtacc ctgaaatgag      240

ctgttgacaa ttaatcatcc ggctcgtata atgtgtggaa ttgtgagcgg ataacaattt      300

cacactacta gagtagtgga ggttactaaa tggcagctca aaatctctac attctgcaca      360

ttcagaccca tggtctgctg cgagggcaga acttggaact ggggcgagat gccgacaccg      420

gcgggcagac caagtacgtc ttagaactgg ctcaagccca agctaaatcc ccacaagtcc      480

aacaagtcga tatcatcacc cgccaaatca ccgacccccg cgtcagtgtt ggttacagtc      540

aggcgatcga accctttgcg cccaaaggtc ggattgtccg tttgcctttt ggccccaaac      600

gctacctccg taaagagctg ctttggcccc atctctacac ctttgcggat gcaattctcc      660

aatatctggc tcagcaaaag cgcaccccga cttggattca ggcccactat gctgatgctg      720

gccaagtggg atcactgctg agtcgctggt tgaatgtacc gctaattttc acagggcatt      780

ctctggggcg gatcaagcta aaaaagctgt tggagcaaga ctggccgctt gaggaaattg      840

aagcgcaatt caatattcaa cagcgaattg atgcggagga gatgacgctc actcatgctg      900

actggattgt cgccagcact cagcaggaag tggaggagca ataccgcgtt tacgatcgct      960

acaacccaga gcgcaagctg gtcattccac cgggtgtcga taccgatcgc ttcaggtttc     1020

agcccttggg cgatcgcggt gttgttctcc aacaggaact gagccgcttt ctgcgcgacc     1080

cagaaaaacc tcaaattctc tgcctctgtc gccccgcacc tcgcaaaaat gtaccggcgc     1140

tggtgcgagc ctttggcgaa catccttggc tgcgcaaaaa agccaacctt gtcttagtac     1200

tgggcagccg ccaagacatc aaccagatgg atcgcggcag tcggcaggtg ttccaagaga     1260

ttttccatct ggtcgatcgc tacgacctct acggcagcgt cgcctatccc aaacagcatc     1320

aggctgatga tgtgccggag ttctatcgcc tagcggctca ttccggcggg gtattcgtca     1380

atccggcgct gaccgaacct tttggtttga caattttgga ggcaggaagc tgcggcgtgc     1440

cggtggtggc aacccatgat ggcggccccc aggaaattct caaacactgt gatttcggca     1500

ctttagttga tgtcagccga cccgctaata tcgcgactgc actcgccacc ctgctgagcg     1560

atcgcgatct ttggcagtgc tatcaccgca atggcattga aaaagttccc gcccattaca     1620

gctgggatca acatgtcaat accctgtttg agcgcatgga aacggtggct ttgcctcgtc     1680

gtcgtgctgt cagtttcgta cggagtcgca aacgcttgat tgatgccaaa cgccttgtcg     1740

ttagtgacat cgacaacaca ctgttgggcg atcgtcaagg actcgaaaat ttaatgacct     1800

atctcgatca gtatcgcgat cattttgcct ttggaattgc cacggggcgt cgcctagact     1860

ctgcccaaga agtcttgaaa gagtggggcg ttccttcgcc aaacttctgg gtgacttccg     1920

tcggcagcga gattcactat ggcaccgatg ctgaaccgga tatcagctgg gaaaagcata     1980

tcaatcgcaa ctggaatcct cagcgcattc gggcagtaat ggcacaacta ccctttcttg     2040

aactgcaacc ggaagaggat caaacaccct tcaaagtcag cttctttgtc cgcgatcgcc     2100

acgagactgt gctgcgagaa gtacggcaac atcttcgccg ccatcgcctg cggctgaagt     2160

caatctattc ccatcaggag tttcttgaca ttctgccgct ggctgcctcg aaaggggatg     2220

cgattcgcca cctctcactc cgctggcgga ttcctcttga gaacattttg gtggcaggcg     2280

attctggtaa cgatgaggaa atgctcaagg gccataatct cggcgttgta gttggcaatt     2340

actcaccgga attggagcca ctgcgcagct acgagcgcgt ctattttgct gagggccact     2400

atgctaatgg cattctggaa gccttaaaac actatcgctt ttttgaggcg atcgcttaat     2460

aaaatgagag tagtggaggt tactaaatgg cactgaatat tccattccga aatgcgtact     2520

atcgttttgc atccagttac tcgtttctct tttttatttc ctggtcgctg tggtggtcgt     2580

tgtacgctat ttggctgaaa ggacatctag ggttgacagg gacggaatta ggtacactgt     2640

attcggtcaa ccagtttacc agcattctat ttatgatgtt ctacggcatc gttcaggata     2700

aactcggtct gaagaaaccg ctcatctggt gtatgagttt catcctggtc ttgaccggac     2760

cgtttatgat ttacgtttat gaaccgttgc tgcaaagcaa tttttctgtg ggtctaattc     2820

tgggggcgct attttttggc ttggggtatc tggcgggatg cggtttgctt gatagcttca     2880

ccgaaaaaat ggcgcgaaat tttcatttcg aatatggaac agcgcgcgcc tggggatctt     2940

ttggctatgc tattggcgcg ttctttgccg gcatcttttt tagtatcagt ccccatatca     3000

acttctggtt ggtgtcgcta tttggcgctg tatttatgat gatcaacatg cgttttaaag     3060

ataaggatca ccagtgcgta gcggcagatg cgggaggggt caaaaaagag gattttatcg     3120

cagttttcaa ggatcgaaac ttctgggttt tcgtcatctt tattgtgggg acgtggtctt     3180

tctataacat ttttgatcaa caactgtttc ctgtctttta ttcaggttta ttcgaatcgc     3240

acgatgtagg aacgcgcctg tatggttatc tcaactcatt ccaggtggtc ctcgaagcgc     3300

tgtgcatggc gattattcct ttctttgtga atcgggtggg gccaaaaaat gcattactta     3360

tcggagttgt gattatggcg ttgcgtatcc tgtcctgcgc gctgttcgtt aacccctgga     3420

ttatttcatt ggtgaagttg ttacatgcca ttgaggttcc actttgtgtc atctccgtgt     3480

tcaaatacag cgtggcaaac tttgataagc gcctgtcgtc cacgatcttt ctgattggtt     3540

ttcaaattgc cagttcgctt gggattgtgc tgctttcgac gccgactggg attctctttg     3600

accacgcagg ctaccagaca gttttcttcg caatttcggg tattgtctgc ctgatgttgc     3660

tatttggcat tttcttcttg agtaaaaaac gcgagcaaat cgttatggaa acgcctgtac     3720

cttcagcaat ctagtaaagg tcgttgacac catcgaatgg tgcaaaacct ttcgcggtat     3780

ggcatgatag cgcccggaag agagtcaatt cagggtggtg aatatgaaac cagtgacgtt     3840

gtacgatgtc gcagagtatg ccggtgtctc gtatcagacc gtttcccgcg tggtgaacca     3900

ggccagccac gtttctgcga aaacgcggga aaaagtggaa gcggcgatgg cggagctgaa     3960

ttacattccc aaccgcgtgg cacaacaact ggcgggcaaa cagtcgttgc tgattggcgt     4020

tgccacctcc agtctggccc tgcacgcgcc gtcgcaaatt gtcgcggcga ttaaatcgcg     4080

cgccgatcaa ctgggtgcca gcgtggtggt gtcgatggtg gaacgaagcg gcgtcgaagc     4140

ctgtaaagcg gcggtgcaca atcttctcgc gcaacgcgtc agtgggctga tcattaacta     4200

tccgctggat gaccaggatg ccattgctgt ggaagctgcc tgcactaatg ttccggcgtt     4260

gtttcttgat gtctcggacc agacacccat caacagtatt attttctccc atgaggacgg     4320

tacgcgactg ggcgtggagc atctggtcgc attgggtcac cagcaaatcg cgctgttggc     4380

gggcccatta agttctgtct cggcgcgcct gcgtctggct ggctggcata aatatctcac     4440

tcgcaatcaa attcagccga tcgcggaacg ggaaggcgac tggagtgcca tgtccggttt     4500

tcaacaaacc atgcaaatgc tgaatgaggg catcgttccc actgcgatgc tggttgccaa     4560

cgatcagatg gcgctgggcg caatgcgcgc cattaccgag tccgggctgc gcgttggtgc     4620

ggatatctcg gtagtgggat acgacgatac cgaagatagc tcatgttata tcccgccgtt     4680

aaccaccatc aaacaggatt ttcgcctgct ggggcaaacc agcgtggacc gcttgctgca     4740

actctcgcag ggccaggcgg tgaagggcaa tcagctgttg cccgtctcac tggtgaaacg     4800

aaaaaccacc ctggcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcgtt     4860

aatgcagctg gcacgacagg tttcccgact ggaaagcggg cagtgataaa ggtccaggca     4920

tcaaataaaa cgaaaggctc agtcgaaaga ctgggccttt cgttttatct gttgtttgtc     4980

ggtgaacgct ctctactaga gtcacactgg ctcaccttcg ggtgggcctt tctgcgttta     5040

tagtcgacct cgagctagca agcttagatc gatccgtcac acgggataat accgcgccac     5100

atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa     5160

ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt     5220

cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg     5280

caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat     5340

attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt gaatgtattt     5400

agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca cctgacgtct     5460

aagaaaccat tattatcatg acattaacct ataaaaatag gcgtatcacg aggccctttc     5520

gtcttcgaat aaatacctgt gacggaagat cacttcgcag aataaataaa tcctggtgtc     5580

cctgttgata ccgggaagcc ctgggccaac ttttggcgaa aatgagacgt tgatcggcac     5640

gtaagaggtt ccaactttca ccataatgaa ataagatcac taccgggcgt attttttgag     5700

ttatcgagat tttcaggagc taaggaagct aaaatggaga aaaaaatcac tggatatacc     5760

accgttgata tatcccaatg gcatcgtaaa gaacattttg aggcatttca gtcagttgct     5820

caatgtacct ataaccagac cgttcagctg gatattacgg cctttttaaa gaccgtaaag     5880

aaaaataagc acaagtttta tccggccttt attcacattc ttgcccgcct gatgaatgct     5940

catccggaat tccgtatggc aatgaaagac ggtgagctgg tgatatggga tagtgttcac     6000

ccttgttaca ccgttttcca tgagcaaact gaaacgtttt catcgctctg gagtgaatac     6060

cacgacgatt tccggcagtt tctacacata tattcgcaag atgtggcgtg ttacggtgaa     6120

aacctggcct atttccctaa agggtttatt gagaatatgt ttttcgtctc agccaatccc     6180

tgggtgagtt tcaccagttt tgatttaaac gtggccaata tggacaactt cttcgccccc     6240

gttttcacca tgggcaaata ttatacgcaa ggcgacaagg tgctgatgcc gctggcgatt     6300

caggttcatc atgccgtttg tgatggcttc catgtcggca gaatgcttaa tgaattacaa     6360

cagtactgcg atgagtggca gggcggggcg taattttttt aaggcagtta ttggtgccct     6420

taaacgcctg gtgctacgcc tgaataagtg ataataagcg gatgaatggc agaaattcga     6480

aagcaaattc gacccggtcg tcggttcagg gcagggtcgt taaatagccg cttatgtcta     6540

ttgctggttt accggtttat tgactaccgg aagcagtgtg accgtgtgct tctcaaatgc     6600

ctgaggccag tttgctcagg ctctccccgt ggaggtaata attgacgata tgatcgacgt     6660


