                         SEQUENCE LISTING

<110>  ENTEROME
       Institut National de recherche pour l'agriculture, 
       l'alimentation et l'environnement (INRAE)
 
<120>  COMPOSITIONS FOR TREATING EPITHELIAL BARRIER FUNCTION DISORDERS

<130>  B378619PCT D40265

<150>  EP20305055.4
<151>  2020-01-23

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  588
<212>  PRT
<213>  firmicutes


<220>
<221>  MISC_FEATURE
<223>  MsbA1 like polypeptide sequence

<400>  1

Met Phe Gln Leu Lys Trp Val Trp Lys Gln Met Glu Gly Phe Arg Lys 
1               5                   10                  15      


Arg Tyr Ile Phe Ala Leu Phe Ser Thr Ala Leu Leu Ala Met Leu Thr 
            20                  25                  30          


Leu Gly Asn Ser Val Ile Thr Ala Ser Ile Met Asp Thr Val Phe Gln 
        35                  40                  45              


Pro Leu Thr Glu Ser Gly Val Val Thr Gln Gln Val Val His His Leu 
    50                  55                  60                  


Ala Val Leu Val Ala Val Leu Ile Gly Phe Thr Leu Phe Arg Thr Ser 
65                  70                  75                  80  


Phe Gln Tyr Leu Ser Ile Met Thr Tyr Glu Gly Cys Ser Gln Lys Leu 
                85                  90                  95      


Ile Phe Lys Leu Arg Arg Asp Leu Tyr Lys Asn Met Gln Glu Gln Asp 
            100                 105                 110         


Gln Asp Phe Phe Ser Lys Thr Arg Thr Gly Asp Leu Met Thr Arg Leu 
        115                 120                 125             


Thr Gly Asp Leu Asp Met Val Arg Phe Ala Val Ala Trp Val Val Arg 
    130                 135                 140                 


Gln Leu Ile His Cys Thr Val Leu Phe Val Thr Thr Ser Ile Val Phe 
145                 150                 155                 160 


Leu Val Thr Asp Trp Leu Phe Ala Leu Ser Met Leu Ala Val Thr Pro 
                165                 170                 175     


Ile Ile Phe Ala Leu Thr Leu Ala Phe Ser Lys Arg Val His Pro Leu 
            180                 185                 190         


Tyr Val Asp Leu Arg Glu Arg Leu Ser Leu Leu Asn Thr Gln Ala Gln 
        195                 200                 205             


Glu Asn Ile Ser Gly Asn Arg Val Val Lys Ala Phe Ala Arg Glu Asp 
    210                 215                 220                 


Tyr Glu Ile Asp Arg Phe Asp Glu Lys Asn Ala Asp Tyr Lys Lys Ala 
225                 230                 235                 240 


Asn Thr Arg Ala Ser Leu Leu Trp Leu Gln Tyr Ser Pro Tyr Ile Glu 
                245                 250                 255     


Gly Leu Ser Gln Ser Leu Ser Ile Ala Val Leu Leu Val Gly Gly Val 
            260                 265                 270         


Phe Leu Ile Thr Gly Arg Ile Ser Ile Gly Thr Phe Thr Leu Phe Asn 
        275                 280                 285             


Gly Leu Thr Trp Thr Leu Thr Asp Pro Met Arg Met Leu Gly Met His 
    290                 295                 300                 


Leu Asn Asp Leu Gln Arg Phe Phe Ala Ser Ser Asn Lys Ile Ile Glu 
305                 310                 315                 320 


Leu Tyr Tyr Ala Lys Ser Thr Ile Thr Ser Arg Pro Asp Ala Lys Lys 
                325                 330                 335     


Val Asp Thr Arg Leu Lys Gly Glu Ile Asp Phe Ser Gly Val Asp Leu 
            340                 345                 350         


Asn Leu His Gly Gln Pro Val Leu Arg His Ile Asp Leu His Ile Asn 
        355                 360                 365             


Pro Gly Glu Thr Val Ala Ile Met Gly Pro Thr Gly Ser Gly Lys Thr 
    370                 375                 380                 


Ser Leu Val Asn Leu Ile Pro Arg Phe Thr Asp Val Ser Gly Gly Thr 
385                 390                 395                 400 


Leu Thr Ile Asp Gly Thr Pro Val Gly Arg Tyr Asp Leu Gln Gly Leu 
                405                 410                 415     


Arg His Ala Ile Gly Ile Ala Thr Gln Asp Val Phe Leu Phe Ser Asp 
            420                 425                 430         


Thr Val Asp Gly Asn Ile Ala Tyr Gly Asp Ser Ser Leu Ser Glu Asp 
        435                 440                 445             


Asp Val Lys Arg Tyr Ala Lys Met Ala Asp Val Asp Phe Val Glu Lys 
    450                 455                 460                 


Leu Pro Asp Gly Phe Asp Thr Leu Ile Gly Glu Arg Gly Thr Gly Leu 
465                 470                 475                 480 


Ser Gly Gly Gln Lys Gln Arg Ile Ala Leu Ala Arg Ala Leu Ala Val 
                485                 490                 495     


Arg Pro Ser Ile Leu Ile Leu Asp Asp Thr Thr Ser Ala Val Asp Leu 
            500                 505                 510         


Glu Thr Glu Lys Tyr Ile Gln Glu Gln Leu Ala Ser Leu Asp Phe Pro 
        515                 520                 525             


Cys Thr Lys Ile Ile Val Ala Gln Arg Ile Ser Thr Thr Lys Arg Ala 
    530                 535                 540                 


Asp Lys Ile Val Ile Leu Asp Lys Gly Arg Val Val Asp Ile Gly Thr 
545                 550                 555                 560 


His Glu Glu Leu Ser Gln Arg Pro Gly Tyr Tyr Arg Glu Val Phe Leu 
                565                 570                 575     


Leu Gln Asn Gly Met Glu Glu Glu Lys Glu Val Val 
            580                 585             


<210>  2
<211>  589
<212>  PRT
<213>  Firmicutes


<220>
<221>  MISC_FEATURE
<223>  MsbA2 like polypeptide sequence

<400>  2

Ala Arg Asn Lys Phe Asp Val Asp Glu Thr Leu Glu Thr Pro Phe Asn 
1               5                   10                  15      


Ile Lys His Leu Leu Arg Ala Gly Val Tyr Ile Gly Arg His Lys Lys 
            20                  25                  30          


Lys Met Ile Leu Ser Leu Leu Phe Ser Ala Ile Ser Ala Ala Cys Ser 
        35                  40                  45              


Leu Leu Gly Pro Met Leu Ile Gln Arg Ala Ile Asp Val Ser Val Pro 
    50                  55                  60                  


Gln Lys Asp Tyr Thr Glu Leu Met Val Val Leu Ala Val Ile Met Leu 
65                  70                  75                  80  


Val Ser Ile Val Ala Ser Val Leu Phe Ala Arg Ala Arg Ser Lys Tyr 
                85                  90                  95      


Met Ile Val Val Gly Gln Glu Ile Ile Tyr Asp Ile Arg Lys Asp Leu 
            100                 105                 110         


Phe Glu His Leu Gln Lys Leu Pro Phe Gln Phe Tyr Asp Asp Arg Pro 
        115                 120                 125             


His Gly Lys Ile Leu Thr Arg Val Ile Asn Tyr Val Asn Ser Val Ser 
    130                 135                 140                 


Asp Ala Leu Ser Asn Gly Ile Ile Asn Phe Val Leu Glu Ile Phe Asn 
145                 150                 155                 160 


Leu Ile Leu Ile Ala Val Phe Met Phe Leu Cys Asp Val Arg Leu Ser 
                165                 170                 175     


Leu Ile Val Met Ala Gly Ile Pro Leu Phe Leu Val Ile Val Leu Leu 
            180                 185                 190         


Ile Lys Pro Ala Gln Arg Arg Ala Trp Gln Asp Val Ser Asn Lys Ser 
        195                 200                 205             


Ser Asn Ile Asn Ala Tyr Leu His Glu Ser Leu Asp Gly Met Lys Ile 
    210                 215                 220                 


Thr Gln Ala Phe Thr Arg Glu Glu Glu Asn Arg Gly Ile Tyr Glu Lys 
225                 230                 235                 240 


Leu Asn Lys Lys Cys Tyr Gln Thr Trp Met Lys Ala Gln Tyr Thr Ser 
                245                 250                 255     


Asn Leu Val Trp Tyr Ser Val Asp Asn Ile Ser Thr Trp Val Val Gly 
            260                 265                 270         


Ala Met Tyr Leu Ile Gly Leu Trp Met Leu Gly Pro Ala Met Gln Ile 
        275                 280                 285             


Gly Thr Leu Ile Ala Ile Ser Ser Tyr Ala Trp Arg Phe Trp Gln Pro 
    290                 295                 300                 


Ile Leu Asn Leu Ser Asn Leu Tyr Asn Thr Phe Ile Asn Ala Val Ala 
305                 310                 315                 320 


Tyr Leu Glu Arg Ile Phe Glu Met Ile Asp Glu Pro Val Thr Val Asp 
                325                 330                 335     


Asp Ala Pro Gly Ala Thr Glu Leu Pro Pro Ile Thr Gly Arg Val Thr 
            340                 345                 350         


Phe Asp Asp Val Thr Phe Ser Tyr Asp Gly Gln Ile Asn Ile Leu Glu 
        355                 360                 365             


His Phe Asn Leu Asp Val Lys Pro Gly Glu Ser Ile Ala Leu Val Gly 
    370                 375                 380                 


Pro Thr Gly Ala Gly Lys Thr Thr Val Val Asn Leu Ile Ser Arg Phe 
385                 390                 395                 400 


Tyr Asn Ile Asp Arg Gly Arg Leu Leu Leu Asp Gly His Asp Ile Ala 
                405                 410                 415     


Gln Val Thr Leu Arg Ser Leu Arg Ser Gln Met Gly Ile Met Leu Gln 
            420                 425                 430         


Asp Ser Phe Ile Phe Ser Gly Thr Ile Met Asp Asn Ile Arg Tyr Gly 
        435                 440                 445             


Arg Leu Asp Ala Thr Asp Glu Glu Val Ile Ala Ala Ala Lys Thr Val 
    450                 455                 460                 


Arg Ala Asp Glu Phe Ile Arg Glu Met Glu Asp Gly Tyr Tyr Thr Gln 
465                 470                 475                 480 


Val Asn Glu Arg Gly Ser Arg Leu Ser Gln Gly Gln Arg Gln Leu Val 
                485                 490                 495     


Ala Phe Ala Arg Thr Leu Leu Ser Asp Pro Lys Ile Leu Val Leu Asp 
            500                 505                 510         


Glu Ala Thr Ser Ser Ile Asp Ala Lys Thr Glu Arg Leu Val Gln Glu 
        515                 520                 525             


Gly Leu Asn Ala Leu Leu Lys Gly Arg Thr Ser Phe Ile Ile Ala His 
    530                 535                 540                 


Arg Leu Ser Thr Ile Lys Asn Cys Asp Arg Ile Leu Tyr Ile Ser Asn 
545                 550                 555                 560 


Lys Gly Ile Ala Glu Met Gly Thr His Gln Gln Leu Leu Glu Lys Lys 
                565                 570                 575     


Gly Tyr Tyr Tyr His Leu Tyr Thr Ala Gln Leu Glu Ser 
            580                 585                 


<210>  3
<211>  1767
<212>  DNA
<213>  Firmicutes


<220>
<221>  misc_feature
<223>  MsbA1 encoding sequence

<400>  3
atgtttcagt taaagtgggt gtggaagcag atggagggct tccgaaagcg gtacatcttt       60

gccctgttct ccacggccct gctggcgatg ctgaccctgg gcaactcagt catcaccgcc      120

agcattatgg acacggtgtt ccagccgctt accgaaagcg gtgtggtcac ccagcaggtg      180

gtgcaccatc tggcggttct ggttgcggtg ctcattgggt ttacgttgtt ccgcaccagc      240

tttcagtacc tatccattat gacctatgag ggctgttccc aaaagctaat cttcaagctc      300

cgccgggatt tgtacaagaa tatgcaggag caggaccagg acttcttctc caaaacccgc      360

accggcgacc tgatgacccg cctcaccggc gacctggata tggtccggtt tgccgtggcc      420

tgggtggtgc ggcagctgat ccactgcaca gtgctgtttg tcaccacctc cattgtgttt      480

ttggtgacag actggctctt tgccctgtcc atgctggcgg taacgcccat tatctttgcc      540

ctgacgctgg ccttctccaa gcgggtgcac cccctgtatg tggacctgcg ggagcgcctc      600

tctttgctaa acacccaggc ccaggagaac atctctggca accgggtggt aaaggccttc      660

gcccgggagg actatgagat cgaccggttc gatgagaaaa atgccgacta taaaaaggcc      720

aacaccaggg cctccctgct gtggctgcag tacagcccct atattgaggg cctgtcccag      780

tccctctcca ttgcggtgct gctggtgggg ggcgtgttcc tcatcaccgg gcgcatctca      840

attgggacct tcaccctgtt caacggcttg acctggacgc tgaccgaccc catgcgcatg      900

ttgggcatgc acctcaacga cctgcagcgt ttcttcgcca gttccaataa gattatcgag      960

ctgtactatg ccaagtccac catcacttcc cggcccgacg ccaaaaaggt ggacacccgc     1020

ctgaaggggg agatcgactt ctccggcgtg gacctgaacc tccacggcca accggtgctg     1080

cgccacattg acctgcatat caatcctggc gaaacggtgg ccattatggg gcccaccggc     1140

tctggaaaga cctcgctggt gaatttgatc ccccggttta cggacgtcag cggcggcacc     1200

ctcaccatag acggcacgcc ggtggggcgc tatgacctgc agggcctgcg ccacgctatc     1260

ggtatcgcca cccaggacgt gttcctgttt tccgacacgg tggacggcaa tatcgcctat     1320

ggcgactcct ccctctccga ggatgacgtg aagcgctatg ccaaaatggc ggatgtggac     1380

tttgtggaaa agcttcccga tggcttcgac accctcattg gcgagcgggg caccggcctt     1440

tccggcggcc agaagcagcg catcgccctg gcccgggccc tggccgtgcg gccctccatc     1500

ctcatcttgg atgacaccac cagcgccgtg gacctggaaa ccgagaagta catccaagag     1560

cagctggcca gcttggactt cccctgcacc aagatcatcg tggcccagcg catttccacc     1620

accaagcggg cggataagat cgtcattttg gataagggcc gggtagtgga catcggcacc     1680

cacgaggagc tgtcccagcg gcccggctac taccgggaag tgttcctgct gcaaaacggc     1740

atggaagagg aaaaggaggt ggtttaa                                         1767


<210>  4
<211>  1770
<212>  DNA
<213>  Firmicutes


<220>
<221>  misc_feature
<223>  Msb A2 encoding sequence

<400>  4
atggcacgca acaagtttga cgtggacgaa accctggaaa ccccatttaa cataaagcat       60

ctgctccggg ccggcgtgta cattggccgc cacaagaaaa agatgatttt gtccctgctg      120

ttctccgcca tttccgccgc ctgctctctg ctggggccca tgctcatcca gcgggccatt      180

gacgtgtccg tgccccaaaa ggactacacc gagctggtgg tgctggccgt catcatgctg      240

gtgtccattg tggcctctgt gctgttcgcc cgggcccgct ccaagtacat gattgtggtg      300

ggccaggaga ttatctacga catccgcaag gacttgttcg agcacctgca gaagctgccc      360

ttccagtttt acgatgaccg gccccacggc aagattttga cccgcgttat caactatgtc      420

aactccgtgt cggatgccct ctccaacggc atcatcaact ttgtgctgga gatcttcaac      480

ctgatcttga ttgccgtgtt catgttcctg tgcgatgtgc gcctgagcct gatcgtcatg      540

gcgggcatcc ccctgtttct ggtcatcgtg ctgctcatca agcccgccca gcgccgggcc      600

tggcaggatg tgtccaacaa gagctccaat atcaacgcct acctccacga aagcctggac      660

ggcatgaaga tcacccaggc cttcacccgg gaggaggaga accgcggcat ctacgagaag      720

ctgaacaaga agtgctatca gacctggatg aaggctcagt acacctccaa cctggtgtgg      780

tactctgtgg acaacatctc cacctgggtg gtgggcgcca tgtacctcat cggcctgtgg      840

atgctggggc ccgccatgca gattggcacc ctcattgcca tttcctccta cgcttggcgg      900

ttctggcagc ccattttgaa cctgtccaac ctgtacaaca ccttcatcaa cgcggtggcc      960

tatctggagc gcatcttcga gatgattgac gagcccgtta ctgtggacga tgcccccggc     1020

gccaccgagc tgccccccat caccggccgt gtcaccttcg atgacgtgac cttctcctat     1080

gatgggcaaa tcaacatctt agagcacttc aacctggatg taaagcccgg cgagtccatt     1140

gccctggtgg gccccaccgg cgccggcaag accactgtag tgaacttgat ctcccggttc     1200

tataacatcg acaggggacg cctgctgctg gatggccacg acatcgccca ggtgaccctc     1260

cgctcccttc gctctcaaat gggcattatg cttcaggaca gcttcatctt ctccggcacc     1320

attatggaca acatccgcta tggccgcctg gacgccaccg atgaggaggt catcgccgcg     1380

gccaagaccg tgcgcgcgga tgagttcatc cgggaaatgg aggatggcta ttacacccag     1440

gtcaacgagc ggggctcccg cctgtcccag ggccagcggc agctggtggc ctttgcccgc     1500

accctgctct ccgaccccaa gattctggtg ctggatgagg ccacctcttc catcgacgcc     1560

aaaaccgagc gcctggtgca agagggcctc aacgcccttc tgaaaggccg taccagcttt     1620

atcatcgccc accgcctttc caccatcaag aactgcgacc gcatcctgta catttccaac     1680

aagggcattg cggagatggg cacccatcag cagctgttgg agaagaaggg atattattac     1740

catctgtaca cggcccagct ggagagctga                                      1770


<210>  5
<211>  32767
<212>  DNA
<213>  Firmicutes


<220>
<221>  misc_feature
<222>  (10000)..(10000)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (17318)..(17318)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (18085)..(18085)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (23533)..(23533)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (23734)..(23734)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (31312)..(31312)
<223>  n is a, c, g, or t

<400>  5
tcggtacccg gggatcccac gtacaacgac acctagacca ctttggaagg cgcgggctat       60

ttcccgcgca gctcgcggat caggtaatcc acctgatcca aagcctgctg cttttgatgg      120

atctcctcca acaggcagca gcggcaccgc cgcagcagcc gaagccgctc cccgactgta      180

tccgatccct gttccgccag cctgacaaag tgcttcagcg tgcccagttc catcccggct      240

tgctgcaaaa accgaaacga aactgcccgc tgcagcgctt cctccccata atgccgggta      300

ccgtccggcg cctgcacccc ttgcaggagc ccattttcct catacagcct cagcagttcc      360

ggcggcagat gaaatcttct gcccgcttct aacaggtcca tgtgtctccc cccgtttctc      420

cccaaaaggg tcttgtgttg ggaagtgccc ttccactctc attatagggg acgggaagcc      480

gcctgtctaa tacccgtttt tcataaggcg caatgcttac agggcataaa aagcgctcaa      540

ccggctggac ggagggtttc cttggcaaac tgaatccact tggagaccgc cgggctgaag      600

ggctgcttgc gcttccaggc caggatgctg gtggccttca gctctggata cagggggcgg      660

caggtgattt tttccgggtc ccagaaggag agggagcccc ggatcgtaat ggaataggcc      720

agctggttat gggccacaat ggaactgatg gccggcagat tggaggtaaa gaccacattc      780

agcttgtcaa actcctctcc aaaccagcct gccagctcac tttgcacact gagcctgcgg      840

ggaagaatta aaggctggcc ggccaaatcc tgaggagtca cccggtccaa ccgggccaag      900

ggggcgtcag ggtgcatcac cgcccaccac tgctcctgcc gggccagccg gatgtattca      960

tatttttcta cgctcaccgg ctccatcagc aggccaatat ccgtcaggcc ccggtccatc     1020

ctgtcctgga tgtggtcggc agtaccggtg tacaggtcaa agcgcaccgc gggatagcgc     1080

gcgcggaacg cccggaacag cggcggcagc agctccacag aggccaggtc tccgcagccc     1140

agggaaacag tcccctcaat ccgctcgtcc tgctccgtca gttccttctc ggtcttatcc     1200

accagctcca gaatctcctc tgcccggcgg cgcagcagca ggccctcatt ggtaagggca     1260

atcttgcggg cgccccggtc aaacagtttg acccccagtt cctcctccat ctggccgatc     1320

tgccggctta aagtaggctg ggtgaggtga agcagctcgg ctgccttggt gatgctctcc     1380

tcccgtgcta ccgccaggaa ataccgcaaa acccgaattt ccacaggcct ttcccccttt     1440

ctttttcccc atcatagcag actcatgctc aaaaagcaat ctcttttcct ttcatgcttc     1500

aatggcattt caagcaggca gccttctgga ggaccgcctg ctttttccct gtgaaaaaaa     1560

gcaagcgcga accctgccgc cgctctggcg ccgtgggctg cgcgcttgct tttgcgctct     1620

attccgttat cccagaggga gctctctccc tgttcagctc tccagctggg ccgtgtacag     1680

atggtaataa tatcccttct tctccaacag ctgctgatgg gtgcccatct ccgcaatgcc     1740

cttgttggaa atgtacagga tgcggtcgca gttcttgatg gtggaaaggc ggtgggcgat     1800

gataaagctg gtacggcctt tcagaagggc gttgaggccc tcttgcacca ggcgctcggt     1860

tttggcgtcg atggaagagg tggcctcatc cagcaccaga atcttggggt cggagagcag     1920

ggtgcgggca aaggccacca gctgccgctg gccctgggac aggcgggagc cccgctcgtt     1980

gacctgggtg taatagccat cctccatttc ccggatgaac tcatccgcgc gcacggtctt     2040

ggccgcggcg atgacctcct catcggtggc gtccaggcgg ccatagcgga tgttgtccat     2100

aatggtgccg gagaagatga agctgtcctg aagcataatg cccatttgag agcgaaggga     2160

gcggagggtc acctgggcga tgtcgtggcc atccagcagc aggcgtcccc tgtcgatgtt     2220

atagaaccgg gagatcaagt tcactacagt ggtcttgccg gcgccggtgg ggcccaccag     2280

ggcaatggac tcgccgggct ttacatccag gttgaagtgc tctaagatgt tgatttgccc     2340

atcataggag aaggtcacgt catcgaaggt gacacggccg gtgatggggg gcagctcggt     2400

ggcgccgggg gcatcgtcca cagtaacggg ctcgtcaatc atctcgaaga tgcgctccag     2460

ataggccacc gcgttgatga aggtgttgta caggttggac aggttcaaaa tgggctgcca     2520

gaaccgccaa gcgtaggagg aaatggcaat gagggtgcca atctgcatgg cgggccccag     2580

catccacagg ccgatgaggt acatggcgcc caccacccag gtggagatgt tgtccacaga     2640

gtaccacacc aggttggagg tgtactgagc cttcatccag gtctgatagc acttcttgtt     2700

cagcttctcg tagatgccgc ggttctcctc ctcccgggtg aaggcctggg tgatcttcat     2760

gccgtccagg ctttcgtgga ggtaggcgtt gatattggag ctcttgttgg acacatcctg     2820

ccaggcccgg cgctgggcgg gcttgatgag cagcacgatg accagaaaca gggggatgcc     2880

cgccatgacg atcaggctca ggcgcacatc gcacaggaac atgaacacgg caatcaagat     2940

caggttgaag atctccagca caaagttgat gatgccgttg gagagggcat ccgacacgga     3000

gttgacatag ttgataacgc gggtcaaaat cttgccgtgg ggccggtcat cgtaaaactg     3060

gaagggcagc ttctgcaggt gctcgaacaa gtccttgcgg atgtcgtaga taatctcctg     3120

gcccaccaca atcatgtact tggagcgggc ccgggcgaac agcacagagg ccacaatgga     3180

caccagcatg atgacggcca gcaccaccag ctcggtgtag tccttttggg gcacggacac     3240

gtcaatggcc cgctggatga gcatgggccc cagcagagag caggcggcgg aaatggcgga     3300

gaacagcagg gacaaaatca tctttttctt gtggcggcca atgtacacgc cggcccggag     3360

cagatgcttt atgttaaatg gggtttccag ggtttcgtcc acgtcaaact tgttgcgtgc     3420

catttaaacc acctcctttt cctcttccat gccgttttgc agcaggaaca cttcccggta     3480

gtagccgggc cgctgggaca gctcctcgtg ggtgccgatg tccactaccc ggcccttatc     3540

caaaatgacg atcttatccg cccgcttggt ggtggaaatg cgctgggcca cgatgatctt     3600

ggtgcagggg aagtccaagc tggccagctg ctcttggatg tacttctcgg tttccaggtc     3660

cacggcgctg gtggtgtcat ccaagatgag gatggagggc cgcacggcca gggcccgggc     3720

cagggcgatg cgctgcttct ggccgccgga aaggccggtg ccccgctcgc caatgagggt     3780

gtcgaagcca tcgggaagct tttccacaaa gtccacatcc gccattttgg catagcgctt     3840

cacgtcatcc tcggagaggg aggagtcgcc ataggcgata ttgccgtcca ccgtgtcgga     3900

aaacaggaac acgtcctggg tggcgatacc gatagcgtgg cgcaggccct gcaggtcata     3960

gcgccccacc ggcgtgccgt ctatggtgag ggtgccgccg ctgacgtccg taaaccgggg     4020

gatcaaattc accagcgagg tctttccaga gccggtgggc cccataatgg ccaccgtttc     4080

gccaggattg atatgcaggt caatgtggcg cagcaccggt tggccgtgga ggttcaggtc     4140

cacgccggag aagtcgatct cccccttcag gcgggtgtcc acctttttgg cgtcgggccg     4200

ggaagtgatg gtggacttgg catagtacag ctcgataatc ttattggaac tggcgaagaa     4260

acgctgcagg tcgttgaggt gcatgcccaa catgcgcatg gggtcggtca gcgtccaggt     4320

caagccgttg aacagggtga aggtcccaat tgagatgcgc ccggtgatga ggaacacgcc     4380

ccccaccagc agcaccgcaa tggagaggga ctgggacagg ccctcaatat aggggctgta     4440

ctgcagccac agcagggagg ccctggtgtt ggccttttta tagtcggcat ttttctcatc     4500

gaaccggtcg atctcatagt cctcccgggc gaaggccttt accacccggt tgccagagat     4560

gttctcctgg gcctgggtgt ttagcaaaga gaggcgctcc cgcaggtcca catacagggg     4620

gtgcacccgc ttggagaagg ccagcgtcag ggcaaagata atgggcgtta ccgccagcat     4680

ggacagggca aagagccagt ctgtcaccaa aaacacaatg gaggtggtga caaacagcac     4740

tgtgcagtgg atcagctgcc gcaccaccca ggccacggca aaccggacca tatccaggtc     4800

gccggtgagg cgggtcatca ggtcgccggt gcgggttttg gagaagaagt cctggtcctg     4860

ctcctgcata ttcttgtaca aatcccggcg gagcttgaag attagctttt gggaacagcc     4920

ctcataggtc ataatggata ggtactgaaa gctggtgcgg aacaacgtaa acccaatgag     4980

caccgcaacc agaaccgcca gatggtgcac cacctgctgg gtgaccacac cgctttcggt     5040

aagcggctgg aacaccgtgt ccataatgct ggcggtgatg actgagttgc ccagggtcag     5100

catcgccagc agggccgtgg agaacagggc aaagatgtac cgctttcgga agccctccat     5160

ctgcttccac acccacttta actgaaacat acaattcctc ccttttcgcg ccgggcagcc     5220

cggcgtgcgt catgtctcct gaaaaggcga aaacctggcc tttcaggccg gcttcgggcc     5280

ctttcccctc tccggaaagg gctcgattcc aagctcccat aattatagcc ctcgctccaa     5340

aaaagggaag gggtttttcc aaaattcccc ttcggtattt cgctgaaatt ccagaggaaa     5400

attttccttt ttgcacagga gccggacaat ccctttcccg cgttccccag ccccggaaaa     5460

cagcgggctg cgaacccctt taaagggcgc cttgcccggc gcaagtcatg acccccggca     5520

aagccagggg cttgggtaat ccctagaagg gcatcgtacc ggcaagcctc tcaaggggca     5580

ctgaaaaatc cgccacttgc atcacttgcc ccacagcctg taaacgggcg ttgtttatcc     5640

aggatcaact tctttacaat agcaagttgt tgctcgcttc tcgcttcgct cgatgcttga     5700

agctaaagct tttttactct ccccagcaga gctgggggtt ctcatttcgc taaagcatac     5760

aaaataaaaa tcccccggcg aagccggggg tatttcatag acgggcaaag ccctctgtta     5820

ctagcggcac gcgcacagcg cgttggtgcg gtctgccagc cgcgatcctg ttacttgccg     5880

cccgtaaacg ggctttcatt gtttagatgt ttcccattgt catctgctcc gccatctggt     5940

cttcatccag ctggtgtttg atgtactccg caatccgttt cgtgttcttc cctgccgtgt     6000

ctacgtagta cccccggcac cagaactctc ggtttcggta tttatacttc agctccggga     6060

acctttcgta cagcattagg ctgctcttcc ctttcaggaa tcccacgaaa cttgaaacgg     6120

agtatttcgg cggtatctcc aagagcatat gcacatggtc cgggcacact tctgcctcta     6180

ctatttttat ctttttccac tcgcacagct ctctcaggat ctttcccact tcccgtcgtt     6240

tctctttgta aaataccttt ctccggtatt ttggcgcaaa tgctatagta atctaaatca     6300

cacattggcg gcatatacga caccaccggc aacaggggtt cttcctctat gtacccggct     6360

gcgccgagta cgtcggaata atcctccgtg gcgcagcctt tgatatatac ctggcatttc     6420

tgtttggtgc catcagtagt aatataaatt cggtcaacaa tcgaatgaac taaagtaaac     6480

agagcttcag gctgtgcgtc ctttgcaaac tcctcaaagg acagcagcct ttttttcatg     6540

ccattcagtt catggacgag atactgattt tcagattgag tatcctccat tcggcgcagc     6600

gcagcttcgc actttgccag ctcgtccgtc aattccttta tatcatcctg gatgaagcgt     6660

ttaagggcgt catctgcctc acgcagattt cgtacctgtg cggcaatatc cgcatttaag     6720

cgttcaatag cctttttggt ttcctggtac tctttctcgc tttggtcagt acggatcatg     6780

ctggcaaccc tgttctccaa aagttgccgg taatagtcgg aatgttcttc ttgcaggctg     6840

gagagtgagt ggataacaaa ttcatcaagc gttacaccct caaccccttt gaaggtacat     6900

tcctttgccc tcaccccagg gcaggcatac ttgaagcggg gcttgccatt cgtccagcga     6960

ttggattctg gcagtacacg cagccgtttt ccgcaaatag ggcaatacat taagccggac     7020

aacaaagcat tggtttttct atggggccgg ttatactttt ctgcaatctc atccagcata     7080

ttttgtgttt ccacccattt ccgggagctg ataaatccct catggcgacc cacagaaaca     7140

atccattcac taatgggttt cctggtaaga agctgtgaga atttgggatt gaaaaaggtg     7200

gaatcctcat cctcaacttt catctggtcg gtcttattat aagcagtaag cccatgctga     7260

ccatcaaagt cggacggttc tccaaacagg ttcccgtcat gctccagaaa atagttgtag     7320

gaatattcat ctgccacgca gtagattgga ttccgcagaa tcagccggat ggtggatgtg     7380

gtaaacttcg cgccatgctt cgtttcatat ttctcactga tgatatttgc cgtctgcaag     7440

agagaacgtg tctcccagaa ggtgctgtag atttccaata caatctcttt ttcttcctgc     7500

acagggacga gaaagctaat ggcactctta ttttttccac ttcccgttgt cacacgttgg     7560

gaagaaaagc cggtcggtgt tttgcctccc agccagcgcc catcttttgc cagctccatc     7620

aagttatcct ggatacgttc agttagaata tcgcgttcaa attctgcgat aatggccagc     7680

acctggatga tgattttgga tgtgctgatc cgcgtattga tattgttgga gcagaccaaa     7740

agcgtcacat cgtgacgctc aaagtattcc agaagccgca tgaggtcgga agttttacgg     7800

ctgattcggt ctaatttgta acaggccaca gccttgattt tccccatctc aatgtcccgg     7860

agtagccttt gaaaatctgg gcggtcggaa tagtaaccac ttaagccttt gtcctcatac     7920

cgggcaaatt cgtaatcttc cgatagagaa agctggttga tagcatagtc ggcactttgc     7980

ttaaactgaa caccaatgct atctccctta tttgtaatgc gggattttct cgcatatatg     8040

gccaccaatc tatcatcaat tcccatctgg attcttgctt tgcgtttcat attcaaatat     8100

cctcctttcc aggacggtga gaaaaccgcc cttttctcca ttattatagg aacgtcctca     8160

tttttgctca aaggtgcgat tatcttcttt caatgtagaa agcaatgctt ttaattcttc     8220

tgcgctaaag tccctcaatt cacgaacgag gaactcggcg cgtttttcag cgaactggcg     8280

cagggattgc tcgctgtctt tcccggtatg gaatacgatc tccataggct gccccctact     8340

cattggtgcc tcttgaccac ttcatagtca aaaccgggcc gctggccgca gtaagtgcag     8400

atgtcctttt ccacccggcc agggtgaacc ctgcgcaaat aataagagcc tgtgccgtag     8460

aagttgttgg cacaggccgg acaaaggcac atgattaaat ttgggggtgt ttcttcgatc     8520

aatcccacgc tgacagccag ggcgcggttg agccggcgaa tatgctgttc ctccagatgt     8580

ccgatgtacg tttccagccg ccttttatca atggtgcgga gctgctccat cagcaccaga     8640

gaaggcagct ccaggccgtt ctctgctttg agaaggtaat gggtaggcag cttggccttg     8700

gcgtccactt tgctggatat ggctgccaca atgaccgtgg ggctgtgctt gtttccagta     8760

tcattctgaa taatcaggac cgggcgataa ccttcctgct cggagccgat tccccggccc     8820

aaatcggcat agtacatatc gccgcgatga tatgttctgt tcatgcttta tgacctccct     8880

ttgaaatgca ggcggctgct gccgcctatg tagaaccgga cagcagaaca gaatgaagac     8940

cggggagaga taaaacaatc ctcttgtttt cattggcccg tcctgctgta cggctcatat     9000

ttcaaagcgt tcctatttgt cctcgacacc ccggaacact gcgggaagtc atcaaacggc     9060

tggcagctca ccagctccac ggggaatctc acccctcgcg tggttctcac gcaaccgccc     9120

ccattgcctg cgacggatca cggcagcaaa ccgcttcaac gctcggacgt taggctggac     9180

gggagtatcg ctccgctgct ggtcatggcc gtaccgggag ccgcccggta ctggcagcct     9240

gctgtttctc gctccttgct gggaagaaca aaccaaagac ctacaatttc ttttttcggt     9300

ggtgtctcgt tgttttctcc cggcagatca ccgcgcagcc gctacctggg ctttggcttt     9360

cgccaaaaca gcgggaatgt gcttgatgaa tgggtatgca gttttcaagg tgccgtgagg     9420

ccataaaaag aacctctcac cctatttgcc gttgagggtg agaggttgca caacgattat     9480

tccaaaattt ttttaagttt tttgagggcc ttcattttcc gaacatgaac agcattgcgg     9540

tacacgccaa gctcgtctgc atattgccgt tctgtctttt cctcaaagaa cagcgcttgg     9600

atcagcgcac gttcttctgg ggtaagcagg gaaagcgcgg tatgtagcct gtccacttcc     9660

agcttgtgaa gcaccacgct ctccacgctt tcctgctcat cagagaattg ctgggcattt     9720

tcatccacca gccgatccaa agaatcttcg cggcttggga tgatctgcac cacttggccc     9780

tcctttccga gaacgaaccg ctcggttttc aaatcgttct caaaatagcg cattttccgg     9840

tcgccctgca tataggcccg gtacacttca tccgtaacct caacatattg gccgcgaatc     9900

catattcttt ttttatcagc gtccacgctg ttttacctcc gatcagtctg aattgcgaga     9960

aattcagact ggtcgggcgg ccccctacaa cgtgggaatn ggggttcctc tatattgaaa    10020

aacgcacctg cagaatggga caacagcccc aacagcaagt gcgtttcctt ttagttcgtg    10080

taaatcatgg catgatggtt cagtatgaaa ggcgtaaagc cacggtgaac agcaagcgat    10140

tttttgacag cctgcgctct gtcgcattat gtcgaaacgc tttttcctcc atggcggctc    10200

cctccgtaag ccgccgatcc cgccagcgtc agggcgtcgt cagtatgagg gcataaagaa    10260

cggcggcctt gattttctca aagccgccga aaaagtaata tgggcgtgtc aataagtctg    10320

ctgcacgacg gctttttttc ttttgccatc gtccggcaga taatgaaaat attatgtttt    10380

aggttcagga tttactaatg cctttacttt cgcaatgaaa tcacagtcgg ttttgcagca    10440

gaaaacgccg ccataaaatt ttgtctgttg ttcaatcagg aaatcatcgt cgccagacat    10500

aagcaggaaa gggacagtga tccctttttg acgaatttct tcgagcaaat ccagtcctgt    10560

gccatcccgc atattataat cagaacagat tgcttcgact ttttgatgtt ccagcaatcg    10620

caacgcatct tttacccctg ttgctgtata aacctcaaaa tatttttcta aagcagaggt    10680

caaaaaacct aaaaaaccca aattgtcgtc tatgacaagc aattttctca ttaacttccc    10740

ccttctatca gctccttatt atgttcttat ctgattggtg gttagaaaat cagaattatt    10800

ttactttcct gttcagccct ttcagaatga acagcgccag aacagcacag gccagcagaa    10860

ctatgatacc aattaagacc tgaaccatgc ttgcatcgta atagccggag atattgaaaa    10920

cggccgtcat gggatatacc gtctttagct gttcggacat acttgcgaac agcccagcaa    10980

acgaataaat ttctgcaaat accagcgcca gccagtaacc ttttttcatc cgggccacca    11040

aggcgataat cggagaaatg gcaaagaaca cgccgatccc gtccagaaga tatgttttca    11100

ggtttcccaa aacaaggcca attgaaagag cttcaaagtg caaaacggcc tcaacgagaa    11160

aggtaatcgc aaaaagcaga agatagatta cgacgctgaa caccagagca agcaccattt    11220

tggagagcgt cagcttcact tcatccacgg gaatgagccg cagggatttc agggtgtcct    11280

cctgttcctc ccggcagatc atatagcttc ccagcagggc aatgaccgca ggcagcacat    11340

aaaaggtggc aagggattgg gccgctgtca taaaccatcc ggcaccgtca atatagcggc    11400

tttcatagaa cgtgaactga ccctgtgcaa agacaatcaa cgccaccatg accgttgcaa    11460

aaccggcaat ccacaagatt ttggaacggc ggagtttccg gcgctccgcc caaagtaaaa    11520

gttccatttc aaatgcacct cactttctct ttttcaaagc agccccagcc agcaggacag    11580

aagcaacgcc ccacacgcct atgcagagga atgcccccgg aatattgagt ggctgggtaa    11640

ttacgacacc cggaatatcc cgcataacaa tggcggtcat gctggacagc ggatgcaggt    11700

acatattcac catcaagagg ataaagccga ggaatgtata aaccagcgtc aggcagacgg    11760

gaagaatata ccccttctgc gctgcggcag ccgccagtat tggcagcacc gcaaaggcgg    11820

tcagcagaga gatttccata cacttccgca gaagataaag gacgctcccg ctgtcaaagg    11880

caatatagcc gggcaggacg ccggtaagga tggacgcggc tgcggtaatc agcatgaagc    11940

agaccgagta caccagcacc acagcaaatt tgctgaaaaa gtacgccatc ttattgaccg    12000

gcacaatcca gagctgtttg agcatatcat attggttttc gttatacatc agcatggtac    12060

acagcatccc cagcaccacc ggcaggataa tccacggggt atagctgaac gccgtccact    12120

tgtaaaactc gatgggttcc acgccggttc ccttaacgct tgcgaagtag aacacggcgg    12180

ccagcggcat aaacagagct gccagcagca tgagccagat aaactttctc cggcgcagct    12240

ttagaaattc aatctgtatc agtttaagca atgccctctc cccccgtaat ctgcttgaaa    12300

tagtcctcaa gggtatcatt gcagatttgg gagctgataa cagccacatc ctgcaccaca    12360

agggccttgt tgattgccgc catatccagt gcggtgtcat agagtcgcag gttatgttcg    12420

tcctgcaccg cataatccgt cacatggaac tgccgttcca aaatcagtga ggctttgggg    12480

acatccgaca cctgaagctg gatgtatttc cgatttttct tttccaaatc ctccatgctg    12540

ctttcttcca gcagtacgcc gtggtcgatg atgccaatat catccgccag aagtgcgatt    12600

tcggaaagaa tgtggctgga aatcaggatg gttttgccgc gatccacgct taaatccttg    12660

ataaaattcc gcacttcggc aatgccgatg gggtcaagcc cgttggtcgg ttcatccagg    12720

atcaaaagct ccgggtcatg caggatggcg ttggcaatgc cgagacgctg cttcataccg    12780

agagaatact tgctgaacag ctttttgtcc cggtaaggaa gccccacgac ttccagtgcg    12840

ttcttgacgg cgttgggccg gggcgtcccg cgtagcttcg caaagatttc aaggttttct    12900

gtgccggtca ggttcgggta aaagccggga gtttcgatga tagccccaat gcggggataa    12960

atgcgcttct catggccttt gatgttctgg ccgaacacat ccacttcgcc ggaagtgatt    13020

ggcgtaaggc ccaaaatcat tttcataatg gtggtcttac cggctccatt tcggcccaaa    13080

agcccgtaaa tccggcccgg cttcacatga atatccacag agctgacggc ggtttgctcg    13140

ccgtaaatct tcgtcagctt tttggtttca atcacaaagt cactcataaa gatgcctctc    13200

tttcttattc tgcttcattt ttccaaatga catagttgta aaggctgcca tccggggaat    13260

agttgatgaa cactttgaaa tcgccctttt cacagggaat gacaaattca acacggattt    13320

ggtcggagtg ttccggcaca taacaggaca cctccgggga agcgttctcc ggcagcccgc    13380

ccagcttatc ggcttcttcc ttccatgttt cctgtatcgc ctccgcagaa gtattgtcct    13440

gtacgccctg cggcagcgca ttgaagaaag tttcaaaatc tccatccatc atctggttaa    13500

agtattcggt agcttcctct gtaatggcct gctggtcggg ggcttcgctg gaagatgggg    13560

cggcctgctg gcaggcgcaa agcgaaaaag cgaacagaac acagaggaat aaactaatca    13620

atcgtttcat aggtctttcc tttcaataag attgcttttt tagagccaca acggatgcgg    13680

cggcaaatgc ggcaccgatc agaagcagcg aacctgcaca gacaagcggc gaagtatggg    13740

gcaaaacgcc ttgcatcagg ctttctacca tagctgcggc tgcttcggaa atatggggat    13800

aaatccccat cacgcttgcc agcgggtgta ttcccgtaag ataggcaggg gcaatgacta    13860

cgggaaccag ataaagcagc gttgcgccaa taggcaggat atatcctttt gacagcgtgg    13920

caagaaacac aatcggaagc atggctatgg ggatcagaag cccgcccgtc agatacaaaa    13980

ggccagcaac cattagtgtt tgggcattca gatcgggaaa gcccccagca atcagcccgc    14040

cgacaacaca taaaagaaag gtaatcaggc acagtcccac ggacatcagg atcaccacag    14100

caacttttga aaagtatagc tgcgcttttg tgataggaat gatgagcagt tctttcagcg    14160

tgtcgttctt gtgttcgtca aaaaataagg ttgtggcgaa cattcccagc acaatcggca    14220

ggaacaggct ggacaggttc ttaaacgcca gtgtgtagag gtcgccaaag ctatccatgt    14280

aggggctgct ccttgcaatg ctgcaagccc gctcaatcgc aaacgcccca aacagcagcg    14340

tcagggccaa aatacaccag acaatcttat tccgcttcca tttctggatt tcagttgcaa    14400

tgatcgtcat gcggtttcct cctttcatgg ttcccattat aagggacgaa ccttgccata    14460

accttgccga aatcttgttt taaccttgct ttgaacgcaa gaaagccctg cgcggtcaca    14520

gggctttcgg aagtatgatg gtaaaggttg taccagctcc ggggacactg gctgccgtga    14580

tggttccttt atggacgctt accagttcct tcgcaatgga gaggcccagc ccgttccctt    14640

tggcagatcg ggagtggtcg cattgataca ttcgttcaaa gatatggggg atgtcagcgg    14700

cggaaatccc tttcccgtta tcggccacca tgatttttgc ctgctgctcc gtttcggtta    14760

tggtcaggga cacttgcctt gcgtcgctgt gcgtcaggat attttgcagc aggttattga    14820

gaatacgggt gtaggcggtg ggatcaaccc ttgtcatgta ttctgtttcg ggtatctcta    14880

tctcatagga aagattgtga ttttccagca gcggcaccca gtcagccata atgttgcggg    14940

aaagctcgtt caggtcgcag acttcaaaat gaaaaatctg ctccccagca tccagcttca    15000

cccattcaaa cagggcggtc acaaagtctt tcaggtgatg ggctttttcc gtagccaccc    15060

gaatatattc ttcctgctcg gcccctgtta cgatcttgct ttccacggcc tccaaatagc    15120

ccaccagaga ggcaagcggc gtttttacat catgggaaag gcttgtcata agtcgtttat    15180

aagcctgctc ggattgcttt tgctggatca gccgggattg gctgctcata gcaatttcgt    15240

tgatgtcata acagatttgc tttgtcaggt cactttcccg cgccagcaca cggcggttca    15300

ggtttccgtt ctttatatcc gtcagggcat ctttaataag ggaaagctgg ccccggacgc    15360

ggtgaagttt tgccaaaagg taagcaatca ccagcagggc aatcaataag gccagcagca    15420

gataaatgtt cagctccatg ctcatgcctc cttattgaac cgatacccca caccccggac    15480

agtctggata taaaacggct gttctggatt tggctcaatt ttcttccgca gtttgctgat    15540

aaaagacatg atgttgctgt cgtcaaaggc atattcctcc gcccatacct gcgtgtaaat    15600

ctgcttcttg gtaaacaccc ggcctttgtt ggacgccaga aacagaagca ggtcaaattc    15660

cttgccggtc agctctaccg ggagattttg aactgtcacc gtccgattga ctttatcaat    15720

caccatatct ttcagcagca tagtggcggc ctcgttcccg gccacgggat ttaaggtggt    15780

atagcgccgg atcagggaat tgacgcgagc catcagctcg ttaatgctga aaggttttgt    15840

caggtaatcg tccgccccca gccgcaggcc agaaacttta tcttcctcat cgcttttggc    15900

ggtcagcatc agcaccggca cattatgttt ctcccggatc ttctgcaata cctgaaagcc    15960

gtccatatcc ggcatcatta catccagaat aatcagagaa caggcatcct tgttttcttc    16020

cagcagccgc aggccctcta aaccgccata cgccaccacc gcagacaaat tttcctgttc    16080

cacgcatttt ttcatcaagg cacaaagttc cttgtcatcg tctataatca aaacactatt    16140

catgtttcaa ggccctccct tgtttcgtcc tgccgtccac cggctttttg gcatctttgg    16200

ggattagcca aaccgttccc attttttcag ctcccggaat gcgtccctcg gagcaataat    16260

aattgatctg ccgtggagaa attccccatt tctcgccggc ttctcttaaa gtcatataat    16320

ccattgcaca tacctccagc acctattata cttcgctctt tcgaagaata caagccaaga    16380

aacatgaacg cctaaataag aatatgaaaa ataagtataa acgatataaa aggaacctct    16440

tgcgttatca aagcaagagg ttcctcattt ggtttaattt agccctccaa taagagcttc    16500

aactttttaa ggaccttcat tttccgaaca tgaacagcat tgcggtacac gccaagctcg    16560

tctgcatatt gccgttctgt cttttcctca aagaacagcg cctggatcag cgcacgttcc    16620

tctggagtca gcagggaaag cgcggtatgt agcctgtcca cttccagctt gtgaagcacc    16680

acgctctcca cactttcctg ctcgtcggag aattgctggg cattttcatc caccagccgg    16740

tccaaagaat cttcgcggct ggggatgatc tgcaccactt ggccctccct tccgagaacg    16800

aaccgctcgg ttttcaaatc gttctcaaaa tagcgcattt tccggtcgcc ctgcatatag    16860

gcccggtaca cttcatccgt gacctcaaca tattggccgc gaatccatat tctcttttta    16920

tcagcgtcca cgctgtttta cctccgatca gtctgaattg cgagaaattc agactggtcg    16980

ggcggccccc tacaacgtgg gaatgatagg gttcctctat atagaaaaac gcacctgcag    17040

aatgggacaa cagacccaac agcaagtgcg tttcttttta gttcgtgtaa atcatggcat    17100

aatagttcag tatgaagggc ataatatccc gttgaaaaac gggaagtttt tttgaccgta    17160

caccgtcaaa caggcggcct acgacataga atcatactcg ctgcttctaa tgagcagcgg    17220

tgtgcaggat gaccaacgca tgaaatatcc ctccagaccc aaacgtggtc tggaggggtg    17280

ggcatgacaa accaccctgc caaaacctcg tttttttnat tggcagggcc agctatacga    17340

tcctggtcag ttcacttttc tccgcactgt cagttctcta aaatttgaac tgctatgcca    17400

ttataaaact ggcataaatc cgtaaaatag aaggagaggt gaactgaaag tgcagaatga    17460

acatgaaaca cttggtgaga tcatcaagaa tgcccgcata aaagcagata ttacagtcga    17520

agatctggcc gccaaggtcg gagtaggcga gagatttata tatcgtatcg agaacgaagg    17580

caaaaagccc agctacgaca ttctctacaa gctgattcgg gaactgtcca ttttacccga    17640

tcagattttc tttccagaaa agcagattga ggattctgaa atggaaagcc ttgtccgtat    17700

gctgtataac tgcgacgagc gttctatgca gatcatcaag gcgacagtta gggcggcctt    17760

ggacagccag cccaaagagt aaaaaagagc cgatgtccgt gggaaattct cacaggttca    17820

tcggctctgc gtctatgcgt ctggctcttt gatgacaacg atatgtagtt gtttcgcctg    17880

gatcaagctc tctcgtttgc acttcgggca gtagagagga taattgatta aaaccgtatc    17940

ctctctgatt cgatcacggg ttttattccc gcagacggga caataaaccc actctgtttg    18000

ctgcatggga atcacctccg ttctcctgtt ttcaagacat ggccgagggc ttgctgcttt    18060

gcaagcccgc cggcgtgtct ttttnattta ttcttccttt tcccggaatc cccaagcctc    18120

aaaatccgta tcgtcctcct ccggctccac ttcctcggca taatcggaac cggtggcctc    18180

taccggggga ttgagcatat agggcgtaac ctgtaccggc gcttcgctct ggatcgccag    18240

caccctacgg gcagccttgc cgcaaaacac catggcggcg gcaaaggcga aatactgcac    18300

acagcttgta agataaagat tcacaatagc cagttcattt ccctgcacag ggacgccctg    18360

ctcaagctgc cgggagacat tttgatggca ggccaccaga gagacaaagg ctgtaatcag    18420

cagcaccacc gcaagagcat aaaaaactgc ggaaaggatc gttccctttt tcgagggttt    18480

cgtgattgga ttgctgtcta tctccatcat tttgccctcc tttcactgcg gggagcgttg    18540

tttctgcggg attgaggctg ggcggctcca tcttgaacgc gctctagcac ctgcagctca    18600

ccctttctca gccggaacac cacatcggcc tgcttcgcaa gttcattgga gtgggtaacg    18660

accaccacac acttgttcat cttgtgggcg ctctctttga gaatatccgt gatgtcctgg    18720

gcggtgtcct cgtccagatt gccggtaggc tcgtccgcca ggatcactgg ggcctcactt    18780

gccagggcac gggcgatggc cacccgctgc tgttggccgc cggagagttt cagcacattc    18840

cgcttggctt cttctttcgt cagccccagg cgctccagaa tgggcagcgg cggcagcttg    18900

gaagtcagcg acacgttctc tgcgggggtc aaatagtcga tcaagttgta cgcctggaaa    18960

ataaacgcca catggttttt ccggtggtcg gaaagccccg tcttggcaat gtcctgccca    19020

tcgaaataaa tctggccgct gttagggctg tccaggccgc cgatcaggga aagcagggtg    19080

gtcttgccgc agccggaagg ccccaggatg gcgtagagtt tgccctgttc catttcggcg    19140

ttgacgcctt ttaagacttt ctttttatta tcgtaggaat atcccacttg cttgatttcc    19200

atgatactca tagtgattac ctcatttcgt tattttaggg gggtggatgg tcttattcca    19260

tctgcgacaa aatctgcttg ggcttcaatc gcatagtcga gatactggac accagcaccg    19320

ccgccaccag cagaatgccg cccacgatag ccaccagcat gaaatgctcc ggggtgacga    19380

tgacattctc tgccgctttg ccgaacagcg tccccagggc gccggcaacc tgcttgctgg    19440

aaaggtaggc caacgggaag gccaccaccg caatcagcag ggtttccagc acatattgta    19500

gaatgaccgc aggcttggca atccccaccg ccagcaaaat gccggtttct cgtttccggc    19560

tgcggatgga catggagagg atgagaatta tcaaaaccat gctcaccaca gtaatcacca    19620

cgatcagcgt cgtaaccaaa gtagtcgtat ccgcaataga gctggaaatg cgctcgtaca    19680

cttcattgct cacggtgatg taataggagt tccagtcgat agaggtgctg ttctgcactt    19740

cctggacaat gctttccagc ttagcagcgt ccgaaacgaa gaagtcaacg gaagtaattc    19800

catttccatt gctggccgta tagggcgcag aaacagccga catggtatcc atatctgtaa    19860

aaatatagtt ctcgtaatcg tataaggttg agggctttgc catagttgcc tgctcgtcgt    19920

catcatccgc gatgacctca aacagaccag caatctcaca ctcaaccaac gggtcgtctg    19980

gattcccgtt tttaatttcg agcgtatcgc caagggacaa tccatatttc tcagccaagc    20040

cttcgtacaa aataattcca ctattaccct ccgttacatg gcagccttct gttaaacgca    20100

aggctccact aagaaacagt ggagaatact ccgaatcaaa gcagcctgtt ccataaaaaa    20160

ggtctgctac atattctcgt tcatccgtcc ctttcatcaa agtatcttga ttatagagat    20220

ttacgattgt ccaatgggaa gtgttatagg attctactcc gtcaatcgcg gcgatttcct    20280

caatcatttc gtctgtgaca ggctgcaggg tatagccgtt gttggcattg acagtaaaac    20340

tggcccctgt tacgccacgc agttcttccg actgctcctc ttgtgcgtct gcaatcgcca    20400

gcccggacat taccagggtg gtaatagcca agagcaggaa gaacaccagc aaggtctttt    20460

tccattttct cgcggtatgt aaaaccgctc gtattcctaa attcgttttg tggttcatat    20520

tgcgcctcct ttactccatc tgcgctaaga tttgcttggg cttcagccgc agggtagaga    20580

tgctggacac cagcactgcc gccaccagca agatacctcc cacaatggcc accaacataa    20640

agtgctccgg cgcgacgatg acattctctg ccgctttgcc gaacagcgtt cccagggcgc    20700

cggcaacctg cttgctggag aggtaggcca gcgggaaggc caccaccgcg atcagcaggg    20760

tttccagcac atactggaga atgaccgcag gtttggcaat acccaccgcc agtaaaatgc    20820

cggtttcccg tttccggctg cggatggaca tggagaggat caggataatc agaaccatgc    20880

tcacagcggt tatgacaatg ataagggtgg taatcagggt gccggtgtca gaaagggcgc    20940

tggaaatatt ctgatatact tcgtcattgg cagtaatgat aaagttgttc cagttaatag    21000

aatcaatatg ttgcacgttc tttattacat tgtctaattg agcagcgtcc tccacataga    21060

aaaaagctct ttcaattcca tcatctgagt aatttactgc caatgcctcc ataacgctgt    21120

tactacagaa agcatattga ttatagtccc aataagtaga cgcatcgtac atatttattg    21180

tgtcgtcctt gtccgccaca atgtcaaata ctcctataag ctccatctca acctctggat    21240

cgttatactc agggttaatt atccctgtga ttttgtctcc tatttttaat ccgttttttt    21300

caacgctttc ccggctgaga ataattccat ctgttacatc ctctgtaata tgagaacctt    21360

caacaagctc aaatcgtcca gatacaaata aactattaaa ttcagaatta tatgcgccat    21420

aagcataata ggcgaatccg tctgggctaa ggctaagatt attcccttct tcatcgtaca    21480

gggtaggcac accgccattt gacgcatcgt acccagtgat accttctacc gaagcgattt    21540

tttgaatcat atctttagtg atgagttctt gcgtactata agtaccatca ctgtcatttg    21600

cccaaccacc agtggataaa tttctctcta ccgtaaagct ggccccggtg gttccccgga    21660

cttcctcagc ctgttcctcc tgggcgtcgg ctatggcaag accggataac accagggtgg    21720

taatggccag gagcaggaag aacaccagca gcgtcttttt ccacttccgt gcgctatata    21780

aaatcgcccg tattcctaaa ttcatatcgc ctgcacctcc ttaactcatc tgcgacaaga    21840

tactcttggg cttcatcttc atgatcgggt aggccgccag tgcggtagag gccacacaca    21900

gcactatgcc gaaagcccac accagtgcgt aatcctcggc ggaaacaacc acctcaatct    21960

cggcaaggcc taaatcctcg ttggattctt ccgcaccttc gctttctccg gtcaagtcca    22020

ccgtttcata ggtttcgctt gtcacctggg agagcaggct gctcccgatc tgatgggaaa    22080

tggctgtgct ggttccgaag gagatcacca gggcgatagc cgccacaagg atcacttcca    22140

gcaggtattg cagcagcacc gagcctttgg aaatacccat ggccagatag acgccggttt    22200

catggattcg cccacggagc cgcagcgtca ggaacagggc cagtaccagg aaacagatca    22260

cggataccac tgcaatggcg ataaagacga tgttctgcaa gccctccaag gattccttgg    22320

cgttctgata gtcgttgtca tagcgagtca gagtgcagct ctcccaatcc acaccatcta    22380

atttctgcac atcggtcata atgcgctcca gctcgtccgg gtcgttcaca taaaaatccc    22440

cgtactggac attggtggtt ccctccgtgc cgtagagcag gaaagagacg gtggagaggt    22500

cggtgaaaac gatgttgtcg taaaggtcat aggacggggc catgccaatg gaatcctgtt    22560

cctcggtgtt ggtgaagatc ccggccaccg tcacggggat ggtcttatct ttgtcctcca    22620

catttcccag cagcatggtg tcgcccacag acaggccatt gcgctgggcg aacttctcat    22680

ggatcagcac ctggctgcct gtttcggtgg tgatggagtt gccctccacc atctcaaagc    22740

cgccatcggt gaaatagctg tcctcctggg agttggagtt ggccaccacc cgtccagcgt    22800

tctcatagcc ctccggcacc tgggcagcgc cctcggtatt gatctccaga aggtttccgt    22860

ctgcgtcaaa ataagtagcg taggtgtagg agcgcagggt gtacctgccg ctcaaaccat    22920

ccacatcaag aatctggctc accgtatcct ccgggatccc gttttccagc gtcttggcgt    22980

tgatggtgaa atagcccagc agggcttttt tgatattggc gttggctgtt tccgtggccg    23040

attgaatgga aaggcaggtc agcattaacg tagccatgac cagcagaaac gccagcagcg    23100

tgagggtctt gccctttttt cggatggaat acaggcaggc ccgtttgcac aggttcatgt    23160

ctgagccacc tcatttcctt cgagtaaaac cagtgggttc acttgtgtac ctcctaacgt    23220

agtttttcgc cggggccgtg ttaccgcccc ggtggtgctc ccgtctgctg ggaacaccct    23280

tatggtacac tacgaaggtg gagttgaggt ggagttgaga tattttttag gtggagttgg    23340

cgataaggtg taaaaaaatc ggcggccttg atttattcaa agccgccgta tagtcaaacg    23400

taggacgtga cgattacctg ctgagcaacg gcttttttct tttgccgtct ggcggggcag    23460

attaaagcga tattcgtttt tttacatctc aatcaactct tttgcatttc cagtaaatgg    23520

tacaccataa aantagacct gccaaagtaa taattccttt gttccatagc caaatattat    23580

tttgatctcc ggcaaatcgg ataaacaaat agacatattc taaccccgga aatcttaata    23640

ggcttcgcgt caataagatt atcagccata taaccccaca gactaatgtt gctatatgtt    23700

cttgcctaca tataatccct aacaaggcac acangsgatr rkaaaaagaa tgttggtggg    23760

aaatacagca caatcaattc ccatattggc atttcgtatc gcataactga cgcgcctgcc    23820

atgctaaaaa ccgcgaataa actggatatt gcaaaagcga ttatataacg taacaatacc    23880

catttgaaaa gagatttgct ttgtgcggca ataatatcaa aattactgtc tgctctcgtc    23940

tttccccatt caccaacaac gattgtgaca aaaaacggga ataccacttc aaagctgacc    24000

ggataaaaat caagcagatt tccggctatg atagaaagaa caatcatagt aaccgtaaag    24060

gccgctgata cgataaagaa atttatcccg aaaattttta cttcgctttc aattcgcgct    24120

ttcattctga cctccaaaac ttgtgtttca aaaacagcag actgccaaac acaagaccgc    24180

ttcctacaag gaaaaatcca tttgcaataa cgctccccat atcaacaaac ggccatctcg    24240

gatgcaccca tatcaaacgg actaaatcgc cggaagtaat caagtaaaat ggcattgcct    24300

ctgccgagcc tacataggtg gcattaaacc caaacaatat tgcggccaga atatagaata    24360

agcgaatgtc aatcatcccc ggtaaggcaa tcgagcaaaa gctgacaaat aaactcgttg    24420

gaactaaaga aacaaagatt gcttttatca acgggacaat acattcaatc agggaaattt    24480

caaacggagc agcaataaaa tagatcatcg tgttaagcaa aagaaaaata cactgcatgg    24540

agaaaacata tagaaatccg cccaacagct ttcccaacac atattgccat tttcgtaagg    24600

ccgatgacat cagcaaagat ttcattcctg tcttagtatc tatcggaata cgtcctgcca    24660

ataagaacat cagaccgaac aataaaacaa ggctgtcgag gctcacaatc cgataaacaa    24720

agtatgctgg ctcattcaaa aactccaacc gagctaaatt cccagcagag gggaaattgt    24780

caagtaaaga aagtgcagtc gctacgagaa gtacacccca tgtaaccaga cgcttgaact    24840

gcattttata ttcataatgg agaacagaaa acattttacg catgggcttt ccctcccata    24900

caatacacat aagcatcttc caaagtcgcc gtgacaggtg tggcctgtaa gaaaagtccg    24960

ctttcgtcca taattcgcgc agtcaatcct tggctctcat atgtcgtcga taacactacc    25020

gatttctttt gaagctcgat aagctggttt tcattttcta aatgtaggat ttttacctta    25080

tcttttaccc gttccaataa ggtggcagat gtgccagcat aaaatagatg ccctttccgc    25140

agaacagcaa gttcttcgca tagctggtga atatcttcga caatatgtgt agaaagcaaa    25200

acggtgcggc cctctcttgc atatcttgac aataggccgc ggaacctcac ccgttcttct    25260

ggatcaagac cggctgtcgg ttcgtcaaca acaagaattt gaggattgcc aatcagcgcc    25320

tgcgcgatgc caaccctccg tttcatgccg cctgaaagct gccctatttt gcgtttggaa    25380

aattccagca tttcaacttg ctccaacacg ctactgacag cttttttgtt atgaatgcct    25440

ttgagttctg ccatgtaatt tacaaagtca aatacagaaa gagaggggta catggcaagt    25500

tcctgtggca aatatccaac tcttgctctg acctcatttc cctgtttcac ggtatcaaaa    25560

ccgcaaatgc ggattgtgcc tgctgatggg gttaataccg taaccaatgc cttcatcagc    25620

gtagtttttc cggcaccatt gtgtcccaac aggccaaaaa caccgctgcc aacatgaaag    25680

ctgacatcat caagggcggt cacgccgctc ttgtattttt tagtaatgtg actaatctca    25740

atgtttgtat tcatacgctc ctccatttaa ctacaatcgt agatttatag actttaatga    25800

tacgggttac tcattgtaac ccgcaccata ttctgtacca gtatgatagg ccggataagg    25860

atagaaatgt tctctgctga attgtacgga aaaagcaacc gtaagtatca gagaaacagc    25920

cagaatagcc gttatcatcc tgtccctgat ctttgatgat tttgtggtga tccgtttgat    25980

tctacgtttt gtcaacacaa aactgagtgc gccaatccct ttaccgggtt ttgtagcttg    26040

aaccgtagac agttccagca gtcggataat agccgcagca tattctgttt ctgtgacttt    26100

tccctgcgaa aattttaagg cattgcaatc gcaatccgtt tcacaatgta gtgaaaaatc    26160

tcctttagca atccacgcaa aagggttgag ccagtttaat atgcaaacat aatcatagat    26220

acgctccaaa agaatatgtt tccgcttaat atgggtcaac tcatggataa agacagcgga    26280

taattcgcca tcggtcagct tttctataac tgttttgctc atgataattg ctgggcggat    26340

tgcgccggta acgcaaatgg ggttatccaa agtcccccaa tatagtgcag gcactttttt    26400

taagccgaca atttccgcac attgtaagca aagagcattt agacgctcag tgctacatat    26460

ctggtatcct ttcaatgccc gctttgccat tatagagcgt atcgtatcat agacgaaaag    26520

aataccgcac ccacacaccc atacccaaca ggcaatataa aatccattta accattcctg    26580

tgtttctggt gatatgagaa acacatccgg tgaaaggaat ggaacgcaaa aaaggatcat    26640

accgcaaagc ggaaaccata gcggcagcgt acaacgcaga atgtgattga taaaaagaga    26700

taaaacacaa aatataccgc caatagcaga tacaaaaata atcgcattga aaatgttacc    26760

gagtatctgc atctgttttc tcctgctgct cgatcaagct ctttagctca tgcaattcat    26820

cagacgaaag attgccgttt ttgacaaatc ccattaccat cttagacagg gaaccatcat    26880

atacgcggct tagaaaactg cggctttccg caagctggca ttcactttct gatactgctg    26940

gataatataa gtatcccttt ccttgacgtt ttgtagtcaa tgctcctttt tttaccaaac    27000

gggcaaggta tgtttgaata gtcgtcttgc tccaacctgt ttcttttaac ctgtctaata    27060

tttcgggaag tgtttgtgga gaattactcc aaacaatctt cattactcgc cactctgact    27120

ctgaaataga aagttgctgc tccataaagc gcctcctttg attgatgctg tgtagtttat    27180

tctattatag cattggaact acatagtgtc aaccattgca tagaatatct atacgtaaaa    27240

ttaaacggaa aactatgcct gtctacgcat ttaagccact gaaaagcccg ctatttcggg    27300

gtttcccggc atggtcgatg ggcaaggcag gacagattat ctaatcctcg ccagagagcg    27360

cttctaaatc tgtagggaaa tccataaaac gttgggcatg gtaactgtta gctacacacc    27420

caacgctttt tttcataaga gtttatagtg ccatcaccac aaaaatgctg taaacttcac    27480

accgttttcc gtattaacca tgttatagat aatttcgtgg tgatccagga tggttttagt    27540

gatatacagc cccaggccgc tgccgccgct gttccggttc cgggatttgt ccacccgata    27600

gaagggagtg aagatacgct ccaaatcttc ctcagcaatg tggacgccgg tattctccac    27660

ggaaaacacc tcgtcttttt gggtgacagt aatcaccgcc cccaccggcg aataggtcac    27720

ggcatttccg atcacattgg tgaacacttt ctccataagc cgacgatccc cctggtagtg    27780

gtatcccggc tggatgtcca tgcgaagctc gatctgcttg tcctccattc ggccacggaa    27840

ctgttggcag acctttcgca acatttggct gatgtccagg tcggtacgct ccaggtggaa    27900

atcgctgccg cccatccgag ccgcagaaag gatttctttc accaatgcct ccatgtcatt    27960

tgtggttttc agacaccggc gcaggtaagt atcgcggtct ttgtattcgc ccacctgata    28020

gatcatgccc tccagttgcc ccttgatgat ggcgatggga gttttcagct catgggatac    28080

agcggtgaaa aattccacgc gctgcttttc ctgttcccgt tctcgctcaa tatctttctt    28140

caactgccag tttgccgagc gcaagctggc cagcgcattg ttgagctgct ccgccatttc    28200

gttcaggctg gcggccagca caccgatctc gtcttgccgg ttgacttcac acttccaggt    28260

catgtccagg gtggtcatcc gctttgccac attgctgata ctgaccagcg gcttagagta    28320

gtaccgggaa caaactaccg ccccaatgac ggagatcaat agaatcacaa cggcaataaa    28380

ggggatgagc ttcaacagga tgtcatagga ctgcgccacc gcaaccaggg cggcattggc    28440

aaatacatgg taggtctgcc cgccttgctg gaatgtagcg gaacagctca tagagggggc    28500

agaagtgtcc atgttctcca tatcggcaaa attcacggag aacaaattat tcccataatc    28560

atcgttgatt tccaccgagg cgttgttcgt catggaaaat tccatcagac tgtccgaact    28620

ggcctcccag ccgtttcgct ccaaaaccgc caccaagtca taaaaatcgg aagtgacttg    28680

gccttccagc tccgtatggt aattcctcgg caggaaaatc atcaccatgc cgtaaatgat    28740

aatgcagcag accaccagca gcgccagcat actgaggaag gttttggcct gaatgctttg    28800

actaatcttc cttctcaatt ttatatcccg cccctctcat ggtttctatg tagtccacac    28860

ccagcttttt acggatgttc ttgatgtggg tattcacgat tttttcatcg ccaatatagt    28920

cgtagcccca aaccgtgtcc agcagccttt ccctggacac cacccggccc tggttctcca    28980

gaaggagctt caaaatctca aattccctgg tggtcaggga aacgctttct gttccaacaa    29040

ggacggtaag gctgtccgtg tccaccgtga tttccttata gcggatcacg gtattgggcg    29100

cagcgccgcc ctgttcagcc cgacgcagca ccgcttcgat atgcttcatc acaaccggca    29160

tggaaaaggg cttggtgata taatcatctg ccagagcgtc aaagcccttc atctggctat    29220

cctcatcatc caatgcggtg agcatgatga tgggaacccg gctctccttc cgcagaatct    29280

cacatacggc aaagccatca attttcggga gcattaaatc cagaagcacc aggtcgggct    29340

tgtttacccg gaactgttca attccttcca ggccatcagc agccagaacc accgtatagc    29400

ctgcgtcctc caggaacgcc ttgataatat tctgaatgga ttcttcatcc tctataatca    29460

aaatcatttt tgacatcgct tgcacctcca aaggtagtgt aacatacaaa ggtggagttt    29520

aggtggagaa gggggccttt tttgaaaaac ctctctattc atattatacc tgaactgtgt    29580

tgccagaaaa agtgtgcgag tttgaatttt gtatatcctc atagcacgag attgtatgac    29640

aggctgtttc tatttgagaa agtcaaaaat gcccctcacc caacaatatc caggcgaggg    29700

gcattagatt taactctcca ataagagctt caactttttg aggaccttca ttttccgaac    29760

gtgaacagca ttacgaaaca cgccaagctc gtctgcatat tgccgttctg tcttttcctc    29820

aaagaacagt gcctggatca gcgcacgttc ctctggagtc agcagggaaa gcgcggtatg    29880

tagcctgtcc acttccagct tgtgaagcac cacgctctcc acactttcct gctcatcgga    29940

gaattgctgg gcattttcat ccaccagccg gtccaaagaa tcttcgcggc tggggatgat    30000

ctgcaccact tggccctcct ttccgagaac gaatcgctcg gttttcaaat cgttctcaaa    30060

atagcgcatt ttccggtcgc cctgcatata ggcccggtac acttcatccg tgacctcgac    30120

aaattggccg cgaatccata ttcttttttt attagcgtcc acgctgtttt acctccgatc    30180

agtctgaatt gcgagaaatt cagactggtc aggcggcccc ctacaacgtg gaaatgatgg    30240

ggttcctcta tatagaaaaa cgcacctgca gaatgagaca acagccccaa cagcaagtgc    30300

gtttcttttt agttcgtgta aatcatggca tgatagttca gtgtgaaggg cgtaaagcca    30360

cgatgaacag caagcggctt ttttgatagc ctgcgccctg tcgcattatg tcgaaacgct    30420

ctttgtttca tggcggctcc ctcctaaagc cgccgtgtca gcgtataggc gtcactcctt    30480

tgttgagggc ataaggaacg gcggccttga tgttactcaa aaccgccgca gtaccctgaa    30540

aatccattat gggcgcacaa agctacctgc cctgcaacgg ttttttcttt ccccgtttag    30600

cggggcagga tagcttgtct tattcgtttt attcttgctc ttgtgcggct gcctctttca    30660

gccgcgaaaa gctctcatcg ctgataatgt gttcaatccg gcaagcgtcg gcctccgcag    30720

tcctggggtc aacgcctgcg gcgataagct gctcggtaaa aaagcaatgg cgctcataga    30780

ttttttcagc aacctcgcgg cccacatcgg tcagatggag aaagtgatct tcgtccattg    30840

taagaaagcc gccgtcccgc aaggtagcca ctgcatggca cacgctgggc tttgacacct    30900

ccatgtgccg ggccacatct acggagcgca ccataccgag tttcttttgg agaacaagga    30960

tggtttccag gtagtcctcc ccggacggag ttattacggg cttcataaac tctttgcgct    31020

cctttgcctg tttttgttgc aattcttccc atgcttcacg aataatcaaa gaaaacacct    31080

tggcacgccc cctttcaaga ataataggtt ctgatgttta tgcaaaagaa atcactttag    31140

tttccagcca cttgccagtt cacgctgttt ccaaaaacga ctataaattc catcttgaga    31200

aatcagttct gcgtgtgttc ctttttgcgc cactttgcca tccgatataa cgacaatctg    31260

attggcattt tttactgttg ataagcgatg tgcaatggaa atcagtgttt tnccctttgt    31320

aagctgttca atcgctgcca acagttcatg ttcattctcc gggtcaacgc tggatgttgc    31380

ttcatccagg ataatgattg gagcatcttt caaaatggct ctcgctatgg aaatacgctg    31440

cttttcaccg ccagacaaag tagagccacc ttcacccacc tttgtgttat atccttcggg    31500

caaagatacg ataaagtcat ggcattgagc cttttttgct gcctccacga tttgctcatg    31560

gcttgcatca ggattgccaa agcgaatatt attctcaatg gtatcattga aaaggtagac    31620

gctttgaaag accatgctga tatattgcat aaggctatcc gcagtgtaat tttttacatc    31680

ctgcccgtcc acaagagcct gaccttcttg aacatcccaa aagcgggcaa tcaggttgca    31740

aagggttgtt ttacctgatc ccgatggccc cacaatcgcg caggtggttc cctgtgggat    31800

aagcaaagaa acatggtcga taatttttct ggacttttca tatccgaaag atacatcccg    31860

aagctcaata tcaaaccgtt tcgggacaag tttatttgat gtcgtgtcca tctgcgggat    31920

gttagtaact tcttccagac ggtttaagcc agcggtgacg acacgggaaa gaaacgcacc    31980

atttcccatc tgctccattt cggaaaaaat gataaaggca ctgacaatca ccatgaggca    32040

ccacggcaac gataaacttc ccatcagata caaaagaacg gcggctaaca tcaaaacact    32100

gccggttatc ttgtaaacag cagagtacca tttcatcaat gccatagaag cgtgttcctg    32160

tgcaagatca gcttctttct ttttgcgaaa agaggcataa acggcatttt cgctaccatc    32220

cgcttgggaa aaggcacgaa gcaccgcaat cccccggata tattccaacg cctgagtcgt    32280

catatcttct tgcgccgcca atactttcgg cgcgtgttcc cttgcaactt gtccaatagc    32340

atgaagaatt aggatgccga caagggaacc tgcaagggta attactgcaa aaacaggaat    32400

ggaaaatagg aagaaaacga tcattaccag cgccatcaac gctccgctgg tcagatcagt    32460

gaccgccatc atggaatatt gttccaactc tgttactgtc gttgtaagta cattctgaat    32520

acttcccaaa cgctgctcgg aaaaatatcc cataggtgct tttcgcatga gggcgccaac    32580

atgaagtctg taatcacgga atatatcaaa gcccttagca ctcatggaaa tatccataag    32640

ccactgaaaa aagaaacggc ccaacacact gatacacaag acagcaagag ctttccagat    32700

cacatccatt gtcaggctgt ccagatcaga ggcaacaata taaaccgccc ataaaaccat    32760

tgccata                                                              32767


<210>  6
<211>  55
<212>  DNA
<213>  artificial

<220>
<223>  A1EcoRfw

<400>  6
ttttgaattc tttaggaggt tttttatgtt tcagttaaag tgggtgtgga agcag            55


<210>  7
<211>  51
<212>  DNA
<213>  artificial

<220>
<223>  A2XbArv

<400>  7
tttttctaga tcagctctcc agctgggccg tgtacagatg gtaataatat c                51


<210>  8
<211>  3537
<212>  DNA
<213>  Firmicutes


<220>
<221>  misc_feature
<223>  nucleotide sequence encoding the MsbA1-MsbA2 transporter

<400>  8
atgtttcagt taaagtgggt gtggaagcag atggagggct tccgaaagcg gtacatcttt       60

gccctgttct ccacggccct gctggcgatg ctgaccctgg gcaactcagt catcaccgcc      120

agcattatgg acacggtgtt ccagccgctt accgaaagcg gtgtggtcac ccagcaggtg      180

gtgcaccatc tggcggttct ggttgcggtg ctcattgggt ttacgttgtt ccgcaccagc      240

tttcagtacc tatccattat gacctatgag ggctgttccc aaaagctaat cttcaagctc      300

cgccgggatt tgtacaagaa tatgcaggag caggaccagg acttcttctc caaaacccgc      360

accggcgacc tgatgacccg cctcaccggc gacctggata tggtccggtt tgccgtggcc      420

tgggtggtgc ggcagctgat ccactgcaca gtgctgtttg tcaccacctc cattgtgttt      480

ttggtgacag actggctctt tgccctgtcc atgctggcgg taacgcccat tatctttgcc      540

ctgacgctgg ccttctccaa gcgggtgcac cccctgtatg tggacctgcg ggagcgcctc      600

tctttgctaa acacccaggc ccaggagaac atctctggca accgggtggt aaaggccttc      660

gcccgggagg actatgagat cgaccggttc gatgagaaaa atgccgacta taaaaaggcc      720

aacaccaggg cctccctgct gtggctgcag tacagcccct atattgaggg cctgtcccag      780

tccctctcca ttgcggtgct gctggtgggg ggcgtgttcc tcatcaccgg gcgcatctca      840

attgggacct tcaccctgtt caacggcttg acctggacgc tgaccgaccc catgcgcatg      900

ttgggcatgc acctcaacga cctgcagcgt ttcttcgcca gttccaataa gattatcgag      960

ctgtactatg ccaagtccac catcacttcc cggcccgacg ccaaaaaggt ggacacccgc     1020

ctgaaggggg agatcgactt ctccggcgtg gacctgaacc tccacggcca accggtgctg     1080

cgccacattg acctgcatat caatcctggc gaaacggtgg ccattatggg gcccaccggc     1140

tctggaaaga cctcgctggt gaatttgatc ccccggttta cggacgtcag cggcggcacc     1200

ctcaccatag acggcacgcc ggtggggcgc tatgacctgc agggcctgcg ccacgctatc     1260

ggtatcgcca cccaggacgt gttcctgttt tccgacacgg tggacggcaa tatcgcctat     1320

ggcgactcct ccctctccga ggatgacgtg aagcgctatg ccaaaatggc ggatgtggac     1380

tttgtggaaa agcttcccga tggcttcgac accctcattg gcgagcgggg caccggcctt     1440

tccggcggcc agaagcagcg catcgccctg gcccgggccc tggccgtgcg gccctccatc     1500

ctcatcttgg atgacaccac cagcgccgtg gacctggaaa ccgagaagta catccaagag     1560

cagctggcca gcttggactt cccctgcacc aagatcatcg tggcccagcg catttccacc     1620

accaagcggg cggataagat cgtcattttg gataagggcc gggtagtgga catcggcacc     1680

cacgaggagc tgtcccagcg gcccggctac taccgggaag tgttcctgct gcaaaacggc     1740

atggaagagg aaaaggaggt ggtttaaatg gcacgcaaca agtttgacgt ggacgaaacc     1800

ctggaaaccc catttaacat aaagcatctg ctccgggccg gcgtgtacat tggccgccac     1860

aagaaaaaga tgattttgtc cctgctgttc tccgccattt ccgccgcctg ctctctgctg     1920

gggcccatgc tcatccagcg ggccattgac gtgtccgtgc cccaaaagga ctacaccgag     1980

ctggtggtgc tggccgtcat catgctggtg tccattgtgg cctctgtgct gttcgcccgg     2040

gcccgctcca agtacatgat tgtggtgggc caggagatta tctacgacat ccgcaaggac     2100

ttgttcgagc acctgcagaa gctgcccttc cagttttacg atgaccggcc ccacggcaag     2160

attttgaccc gcgttatcaa ctatgtcaac tccgtgtcgg atgccctctc caacggcatc     2220

atcaactttg tgctggagat cttcaacctg atcttgattg ccgtgttcat gttcctgtgc     2280

gatgtgcgcc tgagcctgat cgtcatggcg ggcatccccc tgtttctggt catcgtgctg     2340

ctcatcaagc ccgcccagcg ccgggcctgg caggatgtgt ccaacaagag ctccaatatc     2400

aacgcctacc tccacgaaag cctggacggc atgaagatca cccaggcctt cacccgggag     2460

gaggagaacc gcggcatcta cgagaagctg aacaagaagt gctatcagac ctggatgaag     2520

gctcagtaca cctccaacct ggtgtggtac tctgtggaca acatctccac ctgggtggtg     2580

ggcgccatgt acctcatcgg cctgtggatg ctggggcccg ccatgcagat tggcaccctc     2640

attgccattt cctcctacgc ttggcggttc tggcagccca ttttgaacct gtccaacctg     2700

tacaacacct tcatcaacgc ggtggcctat ctggagcgca tcttcgagat gattgacgag     2760

cccgttactg tggacgatgc ccccggcgcc accgagctgc cccccatcac cggccgtgtc     2820

accttcgatg acgtgacctt ctcctatgat gggcaaatca acatcttaga gcacttcaac     2880

ctggatgtaa agcccggcga gtccattgcc ctggtgggcc ccaccggcgc cggcaagacc     2940

actgtagtga acttgatctc ccggttctat aacatcgaca ggggacgcct gctgctggat     3000

ggccacgaca tcgcccaggt gaccctccgc tcccttcgct ctcaaatggg cattatgctt     3060

caggacagct tcatcttctc cggcaccatt atggacaaca tccgctatgg ccgcctggac     3120

gccaccgatg aggaggtcat cgccgcggcc aagaccgtgc gcgcggatga gttcatccgg     3180

gaaatggagg atggctatta cacccaggtc aacgagcggg gctcccgcct gtcccagggc     3240

cagcggcagc tggtggcctt tgcccgcacc ctgctctccg accccaagat tctggtgctg     3300

gatgaggcca cctcttccat cgacgccaaa accgagcgcc tggtgcaaga gggcctcaac     3360

gcccttctga aaggccgtac cagctttatc atcgcccacc gcctttccac catcaagaac     3420

tgcgaccgca tcctgtacat ttccaacaag ggcattgcgg agatgggcac ccatcagcag     3480

ctgttggaga agaagggata ttattaccat ctgtacacgg cccagctgga gagctga        3537


<210>  9
<211>  1177
<212>  PRT
<213>  Firmicutes


<220>
<221>  MISC_FEATURE
<223>  MsbA1-MsbA2 heterodimeric transporter

<400>  9

Met Phe Gln Leu Lys Trp Val Trp Lys Gln Met Glu Gly Phe Arg Lys 
1               5                   10                  15      


Arg Tyr Ile Phe Ala Leu Phe Ser Thr Ala Leu Leu Ala Met Leu Thr 
            20                  25                  30          


Leu Gly Asn Ser Val Ile Thr Ala Ser Ile Met Asp Thr Val Phe Gln 
        35                  40                  45              


Pro Leu Thr Glu Ser Gly Val Val Thr Gln Gln Val Val His His Leu 
    50                  55                  60                  


Ala Val Leu Val Ala Val Leu Ile Gly Phe Thr Leu Phe Arg Thr Ser 
65                  70                  75                  80  


Phe Gln Tyr Leu Ser Ile Met Thr Tyr Glu Gly Cys Ser Gln Lys Leu 
                85                  90                  95      


Ile Phe Lys Leu Arg Arg Asp Leu Tyr Lys Asn Met Gln Glu Gln Asp 
            100                 105                 110         


Gln Asp Phe Phe Ser Lys Thr Arg Thr Gly Asp Leu Met Thr Arg Leu 
        115                 120                 125             


Thr Gly Asp Leu Asp Met Val Arg Phe Ala Val Ala Trp Val Val Arg 
    130                 135                 140                 


Gln Leu Ile His Cys Thr Val Leu Phe Val Thr Thr Ser Ile Val Phe 
145                 150                 155                 160 


Leu Val Thr Asp Trp Leu Phe Ala Leu Ser Met Leu Ala Val Thr Pro 
                165                 170                 175     


Ile Ile Phe Ala Leu Thr Leu Ala Phe Ser Lys Arg Val His Pro Leu 
            180                 185                 190         


Tyr Val Asp Leu Arg Glu Arg Leu Ser Leu Leu Asn Thr Gln Ala Gln 
        195                 200                 205             


Glu Asn Ile Ser Gly Asn Arg Val Val Lys Ala Phe Ala Arg Glu Asp 
    210                 215                 220                 


Tyr Glu Ile Asp Arg Phe Asp Glu Lys Asn Ala Asp Tyr Lys Lys Ala 
225                 230                 235                 240 


Asn Thr Arg Ala Ser Leu Leu Trp Leu Gln Tyr Ser Pro Tyr Ile Glu 
                245                 250                 255     


Gly Leu Ser Gln Ser Leu Ser Ile Ala Val Leu Leu Val Gly Gly Val 
            260                 265                 270         


Phe Leu Ile Thr Gly Arg Ile Ser Ile Gly Thr Phe Thr Leu Phe Asn 
        275                 280                 285             


Gly Leu Thr Trp Thr Leu Thr Asp Pro Met Arg Met Leu Gly Met His 
    290                 295                 300                 


Leu Asn Asp Leu Gln Arg Phe Phe Ala Ser Ser Asn Lys Ile Ile Glu 
305                 310                 315                 320 


Leu Tyr Tyr Ala Lys Ser Thr Ile Thr Ser Arg Pro Asp Ala Lys Lys 
                325                 330                 335     


Val Asp Thr Arg Leu Lys Gly Glu Ile Asp Phe Ser Gly Val Asp Leu 
            340                 345                 350         


Asn Leu His Gly Gln Pro Val Leu Arg His Ile Asp Leu His Ile Asn 
        355                 360                 365             


Pro Gly Glu Thr Val Ala Ile Met Gly Pro Thr Gly Ser Gly Lys Thr 
    370                 375                 380                 


Ser Leu Val Asn Leu Ile Pro Arg Phe Thr Asp Val Ser Gly Gly Thr 
385                 390                 395                 400 


Leu Thr Ile Asp Gly Thr Pro Val Gly Arg Tyr Asp Leu Gln Gly Leu 
                405                 410                 415     


Arg His Ala Ile Gly Ile Ala Thr Gln Asp Val Phe Leu Phe Ser Asp 
            420                 425                 430         


Thr Val Asp Gly Asn Ile Ala Tyr Gly Asp Ser Ser Leu Ser Glu Asp 
        435                 440                 445             


Asp Val Lys Arg Tyr Ala Lys Met Ala Asp Val Asp Phe Val Glu Lys 
    450                 455                 460                 


Leu Pro Asp Gly Phe Asp Thr Leu Ile Gly Glu Arg Gly Thr Gly Leu 
465                 470                 475                 480 


Ser Gly Gly Gln Lys Gln Arg Ile Ala Leu Ala Arg Ala Leu Ala Val 
                485                 490                 495     


Arg Pro Ser Ile Leu Ile Leu Asp Asp Thr Thr Ser Ala Val Asp Leu 
            500                 505                 510         


Glu Thr Glu Lys Tyr Ile Gln Glu Gln Leu Ala Ser Leu Asp Phe Pro 
        515                 520                 525             


Cys Thr Lys Ile Ile Val Ala Gln Arg Ile Ser Thr Thr Lys Arg Ala 
    530                 535                 540                 


Asp Lys Ile Val Ile Leu Asp Lys Gly Arg Val Val Asp Ile Gly Thr 
545                 550                 555                 560 


His Glu Glu Leu Ser Gln Arg Pro Gly Tyr Tyr Arg Glu Val Phe Leu 
                565                 570                 575     


Leu Gln Asn Gly Met Glu Glu Glu Lys Glu Val Val Met Ala Arg Asn 
            580                 585                 590         


Lys Phe Asp Val Asp Glu Thr Leu Glu Thr Pro Phe Asn Ile Lys His 
        595                 600                 605             


Leu Leu Arg Ala Gly Val Tyr Ile Gly Arg His Lys Lys Lys Met Ile 
    610                 615                 620                 


Leu Ser Leu Leu Phe Ser Ala Ile Ser Ala Ala Cys Ser Leu Leu Gly 
625                 630                 635                 640 


Pro Met Leu Ile Gln Arg Ala Ile Asp Val Ser Val Pro Gln Lys Asp 
                645                 650                 655     


Tyr Thr Glu Leu Val Val Leu Ala Val Ile Met Leu Val Ser Ile Val 
            660                 665                 670         


Ala Ser Val Leu Phe Ala Arg Ala Arg Ser Lys Tyr Met Ile Val Val 
        675                 680                 685             


Gly Gln Glu Ile Ile Tyr Asp Ile Arg Lys Asp Leu Phe Glu His Leu 
    690                 695                 700                 


Gln Lys Leu Pro Phe Gln Phe Tyr Asp Asp Arg Pro His Gly Lys Ile 
705                 710                 715                 720 


Leu Thr Arg Val Ile Asn Tyr Val Asn Ser Val Ser Asp Ala Leu Ser 
                725                 730                 735     


Asn Gly Ile Ile Asn Phe Val Leu Glu Ile Phe Asn Leu Ile Leu Ile 
            740                 745                 750         


Ala Val Phe Met Phe Leu Cys Asp Val Arg Leu Ser Leu Ile Val Met 
        755                 760                 765             


Ala Gly Ile Pro Leu Phe Leu Val Ile Val Leu Leu Ile Lys Pro Ala 
    770                 775                 780                 


Gln Arg Arg Ala Trp Gln Asp Val Ser Asn Lys Ser Ser Asn Ile Asn 
785                 790                 795                 800 


Ala Tyr Leu His Glu Ser Leu Asp Gly Met Lys Ile Thr Gln Ala Phe 
                805                 810                 815     


Thr Arg Glu Glu Glu Asn Arg Gly Ile Tyr Glu Lys Leu Asn Lys Lys 
            820                 825                 830         


Cys Tyr Gln Thr Trp Met Lys Ala Gln Tyr Thr Ser Asn Leu Val Trp 
        835                 840                 845             


Tyr Ser Val Asp Asn Ile Ser Thr Trp Val Val Gly Ala Met Tyr Leu 
    850                 855                 860                 


Ile Gly Leu Trp Met Leu Gly Pro Ala Met Gln Ile Gly Thr Leu Ile 
865                 870                 875                 880 


Ala Ile Ser Ser Tyr Ala Trp Arg Phe Trp Gln Pro Ile Leu Asn Leu 
                885                 890                 895     


Ser Asn Leu Tyr Asn Thr Phe Ile Asn Ala Val Ala Tyr Leu Glu Arg 
            900                 905                 910         


Ile Phe Glu Met Ile Asp Glu Pro Val Thr Val Asp Asp Ala Pro Gly 
        915                 920                 925             


Ala Thr Glu Leu Pro Pro Ile Thr Gly Arg Val Thr Phe Asp Asp Val 
    930                 935                 940                 


Thr Phe Ser Tyr Asp Gly Gln Ile Asn Ile Leu Glu His Phe Asn Leu 
945                 950                 955                 960 


Asp Val Lys Pro Gly Glu Ser Ile Ala Leu Val Gly Pro Thr Gly Ala 
                965                 970                 975     


Gly Lys Thr Thr Val Val Asn Leu Ile Ser Arg Phe Tyr Asn Ile Asp 
            980                 985                 990         


Arg Gly Arg Leu Leu Leu Asp Gly  His Asp Ile Ala Gln  Val Thr Leu 
        995                 1000                 1005             


Arg Ser  Leu Arg Ser Gln Met  Gly Ile Met Leu Gln  Asp Ser Phe 
    1010                 1015                 1020             


Ile Phe  Ser Gly Thr Ile Met  Asp Asn Ile Arg Tyr  Gly Arg Leu 
    1025                 1030                 1035             


Asp Ala  Thr Asp Glu Glu Val  Ile Ala Ala Ala Lys  Thr Val Arg 
    1040                 1045                 1050             


Ala Asp  Glu Phe Ile Arg Glu  Met Glu Asp Gly Tyr  Tyr Thr Gln 
    1055                 1060                 1065             


Val Asn  Glu Arg Gly Ser Arg  Leu Ser Gln Gly Gln  Arg Gln Leu 
    1070                 1075                 1080             


Val Ala  Phe Ala Arg Thr Leu  Leu Ser Asp Pro Lys  Ile Leu Val 
    1085                 1090                 1095             


Leu Asp  Glu Ala Thr Ser Ser  Ile Asp Ala Lys Thr  Glu Arg Leu 
    1100                 1105                 1110             


Val Gln  Glu Gly Leu Asn Ala  Leu Leu Lys Gly Arg  Thr Ser Phe 
    1115                 1120                 1125             


Ile Ile  Ala His Arg Leu Ser  Thr Ile Lys Asn Cys  Asp Arg Ile 
    1130                 1135                 1140             


Leu Tyr  Ile Ser Asn Lys Gly  Ile Ala Glu Met Gly  Thr His Gln 
    1145                 1150                 1155             


Gln Leu  Leu Glu Lys Lys Gly  Tyr Tyr Tyr His Leu  Tyr Thr Ala 
    1160                 1165                 1170             


Gln Leu  Glu Ser 
    1175         


