                         SEQUENCE LISTING

<110>  Celex Oncology Innovations Limited
 
<120>  MONOCLONAL ANTIBODIES AGAINST NEONATAL NAV1.5

<130>  21121PCT00

<150>  EP20152789.2
<151>  2020-01-21

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  2016
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser Phe Arg Arg Phe 
1               5                   10                  15      


Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met Ala Glu Lys Gln 
            20                  25                  30          


Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu Gly Leu Pro Glu 
        35                  40                  45              


Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala Ser Lys Lys Leu 
    50                  55                  60                  


Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile Gly Glu Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr Asn Ala Leu Tyr 
            100                 105                 110         


Val Leu Ser Pro Phe His Pro Ile Arg Arg Ala Ala Val Lys Ile Leu 
        115                 120                 125             


Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp Thr Lys Tyr Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Leu His Ala Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala Tyr Thr Thr Glu 
        195                 200                 205             


Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Ser Val Ile Ser Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp Val Met Val Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe Thr Ala Leu Asn 
        275                 280                 285             


Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val Trp Glu Ser Leu 
    290                 295                 300                 


Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu Lys Asn Gly Thr 
305                 310                 315                 320 


Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Thr Cys Pro 
                325                 330                 335     


Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro Asp His Gly Tyr 
            340                 345                 350         


Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala Leu Phe Arg Leu 
        355                 360                 365             


Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Ser 
    370                 375                 380                 


Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val Ile Phe Leu Gly 
385                 390                 395                 400 


Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr 
                405                 410                 415     


Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr Glu Glu Lys Glu Lys 
            420                 425                 430         


Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys Glu His Glu Ala Leu 
        435                 440                 445             


Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser Ser Leu Glu Met Ser 
    450                 455                 460                 


Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg Ser Lys Arg Arg Lys 
465                 470                 475                 480 


Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu Asp Arg Leu Pro Lys 
                485                 490                 495     


Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn His Leu Ser Leu Thr 
            500                 505                 510         


Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg Ser Ser Arg Gly Ser 
        515                 520                 525             


Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser Glu Ala Asp Phe Ala 
    530                 535                 540                 


Asp Asp Glu Asn Ser Thr Ala Gly Glu Ser Glu Ser His His Thr Ser 
545                 550                 555                 560 


Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser Ala Gln Gly Gln Pro 
                565                 570                 575     


Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu His Gly Lys Lys Asn 
            580                 585                 590         


Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Leu Gly Ala Gly Asp 
        595                 600                 605             


Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu Arg Pro Val Met Leu 
    610                 615                 620                 


Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu Glu Pro Gly Gly Pro 
625                 630                 635                 640 


Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp Gly Phe Glu Glu Pro 
                645                 650                 655     


Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser Val Leu Thr Ser Ala 
            660                 665                 670         


Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys Pro Pro Cys Trp Asn 
        675                 680                 685             


Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys Cys Pro Leu Trp Met 
    690                 695                 700                 


Ser Ile Lys Gln Gly Val Lys Leu Val Val Met Asp Pro Phe Thr Asp 
705                 710                 715                 720 


Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr Leu Phe Met Ala Leu 
                725                 730                 735     


Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met Leu Gln Val Gly 
            740                 745                 750         


Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Thr Phe Lys Ile 
        755                 760                 765             


Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln Gly Trp Asn Ile Phe 
    770                 775                 780                 


Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu Leu Gly Leu Ser Arg 
785                 790                 795                 800 


Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
                805                 810                 815     


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile 
            820                 825                 830         


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
        835                 840                 845             


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Asn 
    850                 855                 860                 


Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu Leu Pro Arg Trp His 
865                 870                 875                 880 


Met Met Asp Phe Phe His Ala Phe Leu Ile Ile Phe Arg Ile Leu Cys 
                885                 890                 895     


Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ser Gly Gln 
            900                 905                 910         


Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met Val Ile Gly Asn Leu 
        915                 920                 925             


Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ala 
    930                 935                 940                 


Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu Met Asn Asn Leu Gln 
945                 950                 955                 960 


Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg Phe Val Lys Arg Thr 
                965                 970                 975     


Thr Trp Asp Phe Cys Cys Gly Leu Leu Arg Gln Arg Pro Gln Lys Pro 
            980                 985                 990         


Ala Ala Leu Ala Ala Gln Gly Gln  Leu Pro Ser Cys Ile  Ala Thr Pro 
        995                 1000                 1005             


Tyr Ser  Pro Pro Pro Pro Glu  Thr Glu Lys Val Pro  Pro Thr Arg 
    1010                 1015                 1020             


Lys Glu  Thr Arg Phe Glu Glu  Gly Glu Gln Pro Gly  Gln Gly Thr 
    1025                 1030                 1035             


Pro Gly  Asp Pro Glu Pro Val  Cys Val Pro Ile Ala  Val Ala Glu 
    1040                 1045                 1050             


Ser Asp  Thr Asp Asp Gln Glu  Glu Asp Glu Glu Asn  Ser Leu Gly 
    1055                 1060                 1065             


Thr Glu  Glu Glu Ser Ser Lys  Gln Gln Glu Ser Gln  Pro Val Ser 
    1070                 1075                 1080             


Gly Gly  Pro Glu Ala Pro Pro  Asp Ser Arg Thr Trp  Ser Gln Val 
    1085                 1090                 1095             


Ser Ala  Thr Ala Ser Ser Glu  Ala Glu Ala Ser Ala  Ser Gln Ala 
    1100                 1105                 1110             


Asp Trp  Arg Gln Gln Trp Lys  Ala Glu Pro Gln Ala  Pro Gly Cys 
    1115                 1120                 1125             


Gly Glu  Thr Pro Glu Asp Ser  Cys Ser Glu Gly Ser  Thr Ala Asp 
    1130                 1135                 1140             


Met Thr  Asn Thr Ala Glu Leu  Leu Glu Gln Ile Pro  Asp Leu Gly 
    1145                 1150                 1155             


Gln Asp  Val Lys Asp Pro Glu  Asp Cys Phe Thr Glu  Gly Cys Val 
    1160                 1165                 1170             


Arg Arg  Cys Pro Cys Cys Ala  Val Asp Thr Thr Gln  Ala Pro Gly 
    1175                 1180                 1185             


Lys Val  Trp Trp Arg Leu Arg  Lys Thr Cys Tyr His  Ile Val Glu 
    1190                 1195                 1200             


His Ser  Trp Phe Glu Thr Phe  Ile Ile Phe Met Ile  Leu Leu Ser 
    1205                 1210                 1215             


Ser Gly  Ala Leu Ala Phe Glu  Asp Ile Tyr Leu Glu  Glu Arg Lys 
    1220                 1225                 1230             


Thr Ile  Lys Val Leu Leu Glu  Tyr Ala Asp Lys Met  Phe Thr Tyr 
    1235                 1240                 1245             


Val Phe  Val Leu Glu Met Leu  Leu Lys Trp Val Ala  Tyr Gly Phe 
    1250                 1255                 1260             


Lys Lys  Tyr Phe Thr Asn Ala  Trp Cys Trp Leu Asp  Phe Leu Ile 
    1265                 1270                 1275             


Val Asp  Val Ser Leu Val Ser  Leu Val Ala Asn Thr  Leu Gly Phe 
    1280                 1285                 1290             


Ala Glu  Met Gly Pro Ile Lys  Ser Leu Arg Thr Leu  Arg Ala Leu 
    1295                 1300                 1305             


Arg Pro  Leu Arg Ala Leu Ser  Arg Phe Glu Gly Met  Arg Val Val 
    1310                 1315                 1320             


Val Asn  Ala Leu Val Gly Ala  Ile Pro Ser Ile Met  Asn Val Leu 
    1325                 1330                 1335             


Leu Val  Cys Leu Ile Phe Trp  Leu Ile Phe Ser Ile  Met Gly Val 
    1340                 1345                 1350             


Asn Leu  Phe Ala Gly Lys Phe  Gly Arg Cys Ile Asn  Gln Thr Glu 
    1355                 1360                 1365             


Gly Asp  Leu Pro Leu Asn Tyr  Thr Ile Val Asn Asn  Lys Ser Gln 
    1370                 1375                 1380             


Cys Glu  Ser Leu Asn Leu Thr  Gly Glu Leu Tyr Trp  Thr Lys Val 
    1385                 1390                 1395             


Lys Val  Asn Phe Asp Asn Val  Gly Ala Gly Tyr Leu  Ala Leu Leu 
    1400                 1405                 1410             


Gln Val  Ala Thr Phe Lys Gly  Trp Met Asp Ile Met  Tyr Ala Ala 
    1415                 1420                 1425             


Val Asp  Ser Arg Gly Tyr Glu  Glu Gln Pro Gln Trp  Glu Tyr Asn 
    1430                 1435                 1440             


Leu Tyr  Met Tyr Ile Tyr Phe  Val Ile Phe Ile Ile  Phe Gly Ser 
    1445                 1450                 1455             


Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val Ile Ile  Asp Asn Phe 
    1460                 1465                 1470             


Asn Gln  Gln Lys Lys Lys Leu  Gly Gly Gln Asp Ile  Phe Met Thr 
    1475                 1480                 1485             


Glu Glu  Gln Lys Lys Tyr Tyr  Asn Ala Met Lys Lys  Leu Gly Ser 
    1490                 1495                 1500             


Lys Lys  Pro Gln Lys Pro Ile  Pro Arg Pro Leu Asn  Lys Tyr Gln 
    1505                 1510                 1515             


Gly Phe  Ile Phe Asp Ile Val  Thr Lys Gln Ala Phe  Asp Val Thr 
    1520                 1525                 1530             


Ile Met  Phe Leu Ile Cys Leu  Asn Met Val Thr Met  Met Val Glu 
    1535                 1540                 1545             


Thr Asp  Asp Gln Ser Pro Glu  Lys Ile Asn Ile Leu  Ala Lys Ile 
    1550                 1555                 1560             


Asn Leu  Leu Phe Val Ala Ile  Phe Thr Gly Glu Cys  Ile Val Lys 
    1565                 1570                 1575             


Leu Ala  Ala Leu Arg His Tyr  Tyr Phe Thr Asn Ser  Trp Asn Ile 
    1580                 1585                 1590             


Phe Asp  Phe Val Val Val Ile  Leu Ser Ile Val Gly  Thr Val Leu 
    1595                 1600                 1605             


Ser Asp  Ile Ile Gln Lys Tyr  Phe Phe Ser Pro Thr  Leu Phe Arg 
    1610                 1615                 1620             


Val Ile  Arg Leu Ala Arg Ile  Gly Arg Ile Leu Arg  Leu Ile Arg 
    1625                 1630                 1635             


Gly Ala  Lys Gly Ile Arg Thr  Leu Leu Phe Ala Leu  Met Met Ser 
    1640                 1645                 1650             


Leu Pro  Ala Leu Phe Asn Ile  Gly Leu Leu Leu Phe  Leu Val Met 
    1655                 1660                 1665             


Phe Ile  Tyr Ser Ile Phe Gly  Met Ala Asn Phe Ala  Tyr Val Lys 
    1670                 1675                 1680             


Trp Glu  Ala Gly Ile Asp Asp  Met Phe Asn Phe Gln  Thr Phe Ala 
    1685                 1690                 1695             


Asn Ser  Met Leu Cys Leu Phe  Gln Ile Thr Thr Ser  Ala Gly Trp 
    1700                 1705                 1710             


Asp Gly  Leu Leu Ser Pro Ile  Leu Asn Thr Gly Pro  Pro Tyr Cys 
    1715                 1720                 1725             


Asp Pro  Thr Leu Pro Asn Ser  Asn Gly Ser Arg Gly  Asp Cys Gly 
    1730                 1735                 1740             


Ser Pro  Ala Val Gly Ile Leu  Phe Phe Thr Thr Tyr  Ile Ile Ile 
    1745                 1750                 1755             


Ser Phe  Leu Ile Val Val Asn  Met Tyr Ile Ala Ile  Ile Leu Glu 
    1760                 1765                 1770             


Asn Phe  Ser Val Ala Thr Glu  Glu Ser Thr Glu Pro  Leu Ser Glu 
    1775                 1780                 1785             


Asp Asp  Phe Asp Met Phe Tyr  Glu Ile Trp Glu Lys  Phe Asp Pro 
    1790                 1795                 1800             


Glu Ala  Thr Gln Phe Ile Glu  Tyr Ser Val Leu Ser  Asp Phe Ala 
    1805                 1810                 1815             


Asp Ala  Leu Ser Glu Pro Leu  Arg Ile Ala Lys Pro  Asn Gln Ile 
    1820                 1825                 1830             


Ser Leu  Ile Asn Met Asp Leu  Pro Met Val Ser Gly  Asp Arg Ile 
    1835                 1840                 1845             


His Cys  Met Asp Ile Leu Phe  Ala Phe Thr Lys Arg  Val Leu Gly 
    1850                 1855                 1860             


Glu Ser  Gly Glu Met Asp Ala  Leu Lys Ile Gln Met  Glu Glu Lys 
    1865                 1870                 1875             


Phe Met  Ala Ala Asn Pro Ser  Lys Ile Ser Tyr Glu  Pro Ile Thr 
    1880                 1885                 1890             


Thr Thr  Leu Arg Arg Lys His  Glu Glu Val Ser Ala  Met Val Ile 
    1895                 1900                 1905             


Gln Arg  Ala Phe Arg Arg His  Leu Leu Gln Arg Ser  Leu Lys His 
    1910                 1915                 1920             


Ala Ser  Phe Leu Phe Arg Gln  Gln Ala Gly Ser Gly  Leu Ser Glu 
    1925                 1930                 1935             


Glu Asp  Ala Pro Glu Arg Glu  Gly Leu Ile Ala Tyr  Val Met Ser 
    1940                 1945                 1950             


Glu Asn  Phe Ser Arg Pro Leu  Gly Pro Pro Ser Ser  Ser Ser Ile 
    1955                 1960                 1965             


Ser Ser  Thr Ser Phe Pro Pro  Ser Tyr Asp Ser Val  Thr Arg Ala 
    1970                 1975                 1980             


Thr Ser  Asp Asn Leu Gln Val  Arg Gly Ser Asp Tyr  Ser His Ser 
    1985                 1990                 1995             


Glu Asp  Leu Ala Asp Phe Pro  Pro Ser Pro Asp Arg  Asp Arg Glu 
    2000                 2005                 2010             


Ser Ile  Val 
    2015     


<210>  2
<211>  2016
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser Phe Arg Arg Phe 
1               5                   10                  15      


Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met Ala Glu Lys Gln 
            20                  25                  30          


Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu Gly Leu Pro Glu 
        35                  40                  45              


Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala Ser Lys Lys Leu 
    50                  55                  60                  


Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile Gly Glu Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr Asn Ala Leu Tyr 
            100                 105                 110         


Val Leu Ser Pro Phe His Pro Ile Arg Arg Ala Ala Val Lys Ile Leu 
        115                 120                 125             


Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp Thr Lys Tyr Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Leu His Ala Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala Tyr Val Ser Glu 
        195                 200                 205             


Asn Ile Lys Leu Gly Asn Leu Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp Val Met Val Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe Thr Ala Leu Asn 
        275                 280                 285             


Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val Trp Glu Ser Leu 
    290                 295                 300                 


Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu Lys Asn Gly Thr 
305                 310                 315                 320 


Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Thr Cys Pro 
                325                 330                 335     


Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro Asp His Gly Tyr 
            340                 345                 350         


Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala Leu Phe Arg Leu 
        355                 360                 365             


Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Ser 
    370                 375                 380                 


Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val Ile Phe Leu Gly 
385                 390                 395                 400 


Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr 
                405                 410                 415     


Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr Glu Glu Lys Glu Lys 
            420                 425                 430         


Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys Glu His Glu Ala Leu 
        435                 440                 445             


Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser Ser Leu Glu Met Ser 
    450                 455                 460                 


Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg Ser Lys Arg Arg Lys 
465                 470                 475                 480 


Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu Asp Arg Leu Pro Lys 
                485                 490                 495     


Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn His Leu Ser Leu Thr 
            500                 505                 510         


Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg Ser Ser Arg Gly Ser 
        515                 520                 525             


Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser Glu Ala Asp Phe Ala 
    530                 535                 540                 


Asp Asp Glu Asn Ser Thr Ala Gly Glu Ser Glu Ser His His Thr Ser 
545                 550                 555                 560 


Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser Ala Gln Gly Gln Pro 
                565                 570                 575     


Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu His Gly Lys Lys Asn 
            580                 585                 590         


Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Leu Gly Ala Gly Asp 
        595                 600                 605             


Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu Arg Pro Val Met Leu 
    610                 615                 620                 


Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu Glu Pro Gly Gly Pro 
625                 630                 635                 640 


Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp Gly Phe Glu Glu Pro 
                645                 650                 655     


Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser Val Leu Thr Ser Ala 
            660                 665                 670         


Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys Pro Pro Cys Trp Asn 
        675                 680                 685             


Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys Cys Pro Leu Trp Met 
    690                 695                 700                 


Ser Ile Lys Gln Gly Val Lys Leu Val Val Met Asp Pro Phe Thr Asp 
705                 710                 715                 720 


Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr Leu Phe Met Ala Leu 
                725                 730                 735     


Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met Leu Gln Val Gly 
            740                 745                 750         


Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Thr Phe Lys Ile 
        755                 760                 765             


Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln Gly Trp Asn Ile Phe 
    770                 775                 780                 


Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu Leu Gly Leu Ser Arg 
785                 790                 795                 800 


Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
                805                 810                 815     


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile 
            820                 825                 830         


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
        835                 840                 845             


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Asn 
    850                 855                 860                 


Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu Leu Pro Arg Trp His 
865                 870                 875                 880 


Met Met Asp Phe Phe His Ala Phe Leu Ile Ile Phe Arg Ile Leu Cys 
                885                 890                 895     


Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ser Gly Gln 
            900                 905                 910         


Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met Val Ile Gly Asn Leu 
        915                 920                 925             


Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ala 
    930                 935                 940                 


Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu Met Asn Asn Leu Gln 
945                 950                 955                 960 


Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg Phe Val Lys Arg Thr 
                965                 970                 975     


Thr Trp Asp Phe Cys Cys Gly Leu Leu Arg Gln Arg Pro Gln Lys Pro 
            980                 985                 990         


Ala Ala Leu Ala Ala Gln Gly Gln  Leu Pro Ser Cys Ile  Ala Thr Pro 
        995                 1000                 1005             


Tyr Ser  Pro Pro Pro Pro Glu  Thr Glu Lys Val Pro  Pro Thr Arg 
    1010                 1015                 1020             


Lys Glu  Thr Arg Phe Glu Glu  Gly Glu Gln Pro Gly  Gln Gly Thr 
    1025                 1030                 1035             


Pro Gly  Asp Pro Glu Pro Val  Cys Val Pro Ile Ala  Val Ala Glu 
    1040                 1045                 1050             


Ser Asp  Thr Asp Asp Gln Glu  Glu Asp Glu Glu Asn  Ser Leu Gly 
    1055                 1060                 1065             


Thr Glu  Glu Glu Ser Ser Lys  Gln Gln Glu Ser Gln  Pro Val Ser 
    1070                 1075                 1080             


Gly Gly  Pro Glu Ala Pro Pro  Asp Ser Arg Thr Trp  Ser Gln Val 
    1085                 1090                 1095             


Ser Ala  Thr Ala Ser Ser Glu  Ala Glu Ala Ser Ala  Ser Gln Ala 
    1100                 1105                 1110             


Asp Trp  Arg Gln Gln Trp Lys  Ala Glu Pro Gln Ala  Pro Gly Cys 
    1115                 1120                 1125             


Gly Glu  Thr Pro Glu Asp Ser  Cys Ser Glu Gly Ser  Thr Ala Asp 
    1130                 1135                 1140             


Met Thr  Asn Thr Ala Glu Leu  Leu Glu Gln Ile Pro  Asp Leu Gly 
    1145                 1150                 1155             


Gln Asp  Val Lys Asp Pro Glu  Asp Cys Phe Thr Glu  Gly Cys Val 
    1160                 1165                 1170             


Arg Arg  Cys Pro Cys Cys Ala  Val Asp Thr Thr Gln  Ala Pro Gly 
    1175                 1180                 1185             


Lys Val  Trp Trp Arg Leu Arg  Lys Thr Cys Tyr His  Ile Val Glu 
    1190                 1195                 1200             


His Ser  Trp Phe Glu Thr Phe  Ile Ile Phe Met Ile  Leu Leu Ser 
    1205                 1210                 1215             


Ser Gly  Ala Leu Ala Phe Glu  Asp Ile Tyr Leu Glu  Glu Arg Lys 
    1220                 1225                 1230             


Thr Ile  Lys Val Leu Leu Glu  Tyr Ala Asp Lys Met  Phe Thr Tyr 
    1235                 1240                 1245             


Val Phe  Val Leu Glu Met Leu  Leu Lys Trp Val Ala  Tyr Gly Phe 
    1250                 1255                 1260             


Lys Lys  Tyr Phe Thr Asn Ala  Trp Cys Trp Leu Asp  Phe Leu Ile 
    1265                 1270                 1275             


Val Asp  Val Ser Leu Val Ser  Leu Val Ala Asn Thr  Leu Gly Phe 
    1280                 1285                 1290             


Ala Glu  Met Gly Pro Ile Lys  Ser Leu Arg Thr Leu  Arg Ala Leu 
    1295                 1300                 1305             


Arg Pro  Leu Arg Ala Leu Ser  Arg Phe Glu Gly Met  Arg Val Val 
    1310                 1315                 1320             


Val Asn  Ala Leu Val Gly Ala  Ile Pro Ser Ile Met  Asn Val Leu 
    1325                 1330                 1335             


Leu Val  Cys Leu Ile Phe Trp  Leu Ile Phe Ser Ile  Met Gly Val 
    1340                 1345                 1350             


Asn Leu  Phe Ala Gly Lys Phe  Gly Arg Cys Ile Asn  Gln Thr Glu 
    1355                 1360                 1365             


Gly Asp  Leu Pro Leu Asn Tyr  Thr Ile Val Asn Asn  Lys Ser Gln 
    1370                 1375                 1380             


Cys Glu  Ser Leu Asn Leu Thr  Gly Glu Leu Tyr Trp  Thr Lys Val 
    1385                 1390                 1395             


Lys Val  Asn Phe Asp Asn Val  Gly Ala Gly Tyr Leu  Ala Leu Leu 
    1400                 1405                 1410             


Gln Val  Ala Thr Phe Lys Gly  Trp Met Asp Ile Met  Tyr Ala Ala 
    1415                 1420                 1425             


Val Asp  Ser Arg Gly Tyr Glu  Glu Gln Pro Gln Trp  Glu Tyr Asn 
    1430                 1435                 1440             


Leu Tyr  Met Tyr Ile Tyr Phe  Val Ile Phe Ile Ile  Phe Gly Ser 
    1445                 1450                 1455             


Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val Ile Ile  Asp Asn Phe 
    1460                 1465                 1470             


Asn Gln  Gln Lys Lys Lys Leu  Gly Gly Gln Asp Ile  Phe Met Thr 
    1475                 1480                 1485             


Glu Glu  Gln Lys Lys Tyr Tyr  Asn Ala Met Lys Lys  Leu Gly Ser 
    1490                 1495                 1500             


Lys Lys  Pro Gln Lys Pro Ile  Pro Arg Pro Leu Asn  Lys Tyr Gln 
    1505                 1510                 1515             


Gly Phe  Ile Phe Asp Ile Val  Thr Lys Gln Ala Phe  Asp Val Thr 
    1520                 1525                 1530             


Ile Met  Phe Leu Ile Cys Leu  Asn Met Val Thr Met  Met Val Glu 
    1535                 1540                 1545             


Thr Asp  Asp Gln Ser Pro Glu  Lys Ile Asn Ile Leu  Ala Lys Ile 
    1550                 1555                 1560             


Asn Leu  Leu Phe Val Ala Ile  Phe Thr Gly Glu Cys  Ile Val Lys 
    1565                 1570                 1575             


Leu Ala  Ala Leu Arg His Tyr  Tyr Phe Thr Asn Ser  Trp Asn Ile 
    1580                 1585                 1590             


Phe Asp  Phe Val Val Val Ile  Leu Ser Ile Val Gly  Thr Val Leu 
    1595                 1600                 1605             


Ser Asp  Ile Ile Gln Lys Tyr  Phe Phe Ser Pro Thr  Leu Phe Arg 
    1610                 1615                 1620             


Val Ile  Arg Leu Ala Arg Ile  Gly Arg Ile Leu Arg  Leu Ile Arg 
    1625                 1630                 1635             


Gly Ala  Lys Gly Ile Arg Thr  Leu Leu Phe Ala Leu  Met Met Ser 
    1640                 1645                 1650             


Leu Pro  Ala Leu Phe Asn Ile  Gly Leu Leu Leu Phe  Leu Val Met 
    1655                 1660                 1665             


Phe Ile  Tyr Ser Ile Phe Gly  Met Ala Asn Phe Ala  Tyr Val Lys 
    1670                 1675                 1680             


Trp Glu  Ala Gly Ile Asp Asp  Met Phe Asn Phe Gln  Thr Phe Ala 
    1685                 1690                 1695             


Asn Ser  Met Leu Cys Leu Phe  Gln Ile Thr Thr Ser  Ala Gly Trp 
    1700                 1705                 1710             


Asp Gly  Leu Leu Ser Pro Ile  Leu Asn Thr Gly Pro  Pro Tyr Cys 
    1715                 1720                 1725             


Asp Pro  Thr Leu Pro Asn Ser  Asn Gly Ser Arg Gly  Asp Cys Gly 
    1730                 1735                 1740             


Ser Pro  Ala Val Gly Ile Leu  Phe Phe Thr Thr Tyr  Ile Ile Ile 
    1745                 1750                 1755             


Ser Phe  Leu Ile Val Val Asn  Met Tyr Ile Ala Ile  Ile Leu Glu 
    1760                 1765                 1770             


Asn Phe  Ser Val Ala Thr Glu  Glu Ser Thr Glu Pro  Leu Ser Glu 
    1775                 1780                 1785             


Asp Asp  Phe Asp Met Phe Tyr  Glu Ile Trp Glu Lys  Phe Asp Pro 
    1790                 1795                 1800             


Glu Ala  Thr Gln Phe Ile Glu  Tyr Ser Val Leu Ser  Asp Phe Ala 
    1805                 1810                 1815             


Asp Ala  Leu Ser Glu Pro Leu  Arg Ile Ala Lys Pro  Asn Gln Ile 
    1820                 1825                 1830             


Ser Leu  Ile Asn Met Asp Leu  Pro Met Val Ser Gly  Asp Arg Ile 
    1835                 1840                 1845             


His Cys  Met Asp Ile Leu Phe  Ala Phe Thr Lys Arg  Val Leu Gly 
    1850                 1855                 1860             


Glu Ser  Gly Glu Met Asp Ala  Leu Lys Ile Gln Met  Glu Glu Lys 
    1865                 1870                 1875             


Phe Met  Ala Ala Asn Pro Ser  Lys Ile Ser Tyr Glu  Pro Ile Thr 
    1880                 1885                 1890             


Thr Thr  Leu Arg Arg Lys His  Glu Glu Val Ser Ala  Met Val Ile 
    1895                 1900                 1905             


Gln Arg  Ala Phe Arg Arg His  Leu Leu Gln Arg Ser  Leu Lys His 
    1910                 1915                 1920             


Ala Ser  Phe Leu Phe Arg Gln  Gln Ala Gly Ser Gly  Leu Ser Glu 
    1925                 1930                 1935             


Glu Asp  Ala Pro Glu Arg Glu  Gly Leu Ile Ala Tyr  Val Met Ser 
    1940                 1945                 1950             


Glu Asn  Phe Ser Arg Pro Leu  Gly Pro Pro Ser Ser  Ser Ser Ile 
    1955                 1960                 1965             


Ser Ser  Thr Ser Phe Pro Pro  Ser Tyr Asp Ser Val  Thr Arg Ala 
    1970                 1975                 1980             


Thr Ser  Asp Asn Leu Gln Val  Arg Gly Ser Asp Tyr  Ser His Ser 
    1985                 1990                 1995             


Glu Asp  Leu Ala Asp Phe Pro  Pro Ser Pro Asp Arg  Asp Arg Glu 
    2000                 2005                 2010             


Ser Ile  Val 
    2015     


<210>  3
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  3

Tyr Val Ser Glu Asn Ile Lys Leu Gly Asn Leu Ser Ala Leu Arg Thr 
1               5                   10                  15      


Phe Arg Val Leu Arg Ala Leu Lys Thr Ile Ser Val Ile Pro 
            20                  25                  30  


<210>  4
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence of Homo sapiens variants


<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X is K or D

<400>  4

Tyr Val Thr Glu Phe Val Xaa Leu Gly Asn Val Ser Ala Leu Arg Thr 
1               5                   10                  15      


Phe Arg Val Leu Arg Ala Leu Lys Thr Ile Ser Val Ile Pro 
            20                  25                  30  


<210>  5
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NESO peptide sequence


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  AMIDATION

<400>  5

Val Ser Glu Asn Ile Lys Leu Gly Asn Leu Ser Ala Leu Arg Cys 
1               5                   10                  15  


<210>  6
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  6
caggttactc tgaaagwgts tg                                                22


<210>  7
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  7
ggaagatcta tagacagatg ggggtgtcgt tttggc                                 36


<210>  8
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  8
gayattgtgm tsacmcarwc tmca                                              24


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  9
ggatacagtt ggtgcagcat c                                                 21


<210>  10
<211>  357
<212>  DNA
<213>  Mus musculus

<400>  10
caggttactc tgaaagtgtc tggccctggg atattgcagc cctcccagac cctcagtctg       60

acctgttctt tttctgggtt ttcactgacc acttctggta tgggtgtgag ctggattcgt      120

caggctgcag gaaagggtct ggagtggctg gcacacattt actgggatga tgacaagcgc      180

tataacccag ccctgaagag ccggctcaca atctccaagg atacctccag caaccaagta      240

ttcctcaaca tcaccagtgt ggacactgca gatactgcca catactactg tgctcgaagg      300

gaggactatg ttacgagttt gctaagtggg gccaagggac tctggtcact gtgtttg         357


<210>  11
<211>  330
<212>  DNA
<213>  Mus musculus

<400>  11
gatattgtgc tgacccagtc tcctgcttcc ttagctgtat ctctggggca gagggccagc       60

atctcataca gggccagcaa aagtgtcagt acatctggct atagttatat gcactggaac      120

cgacagaagc caggacagcc acccagactc ctcatctatc ttgtatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acattaggga gcttacacgt      300

tcggaggggg gaccaagctg gaaatacgac                                       330


<210>  12
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  12

Gln Val Thr Leu Lys Val Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Thr Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Ala Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val 
65                  70                  75                  80  


Phe Leu Asn Ile Thr Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Glu Asp Tyr Val Thr Ser Leu Leu Ser Gly Ala Lys 
            100                 105                 110         


Gly Leu Trp Ser Leu Cys Leu 
        115                 


<210>  13
<211>  110
<212>  PRT
<213>  Mus musculus

<400>  13

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Ser Ile Ser Tyr Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Asn Arg Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ile Arg 
                85                  90                  95      


Glu Leu Thr Arg Ser Glu Gly Gly Pro Ser Trp Lys Tyr Asp 
            100                 105                 110 


<210>  14
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  14

Gly Phe Ser Leu Thr Thr Ser 
1               5           


<210>  15
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  15

Tyr Trp Asp Asp Asp 
1               5   


<210>  16
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  16

Arg Glu Asp Tyr Val Thr Ser Leu Leu 
1               5                   


<210>  17
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  17

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  18
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  18

Leu Val Ser Asn Leu Glu Ser 
1               5           


<210>  19
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  19

Gln His Ile Arg Glu Leu Thr Arg Ser Glu 
1               5                   10  


