                         SEQUENCE LISTING

<110>  ANKA Angewandte Kaffeetechnologie GmbH
 
<120>  Enzyme zum Abbau von Acrylamid

<130>  CA 2046-03WO

<140>  noch nicht bekannt
<141>  2021-01-21

<150>  EP 20152853.6
<151>  2020-01-21

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (94)..(94)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (175)..(175)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (201)..(201)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (217)..(217)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (221)..(221)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (225)..(225)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (229)..(229)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (317)..(317)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (328)..(328)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (424)..(424)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (445)..(445)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (448)..(448)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (453)..(454)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (457)..(457)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (507)..(507)
<223>  Xaa can be any naturally occurring amino acid

<400>  1

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Xaa Val Thr Gly Leu Leu Gly Ser Xaa Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Xaa Lys Leu Gly Ala Trp Xaa Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Xaa Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Xaa Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Xaa Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Xaa Gly Gly Phe Xaa Ile Glu Gln 
    210                 215                 220                 


Xaa Ile Asp His Xaa Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Xaa Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Xaa Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Xaa Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Xaa Leu Glu Xaa 
        435                 440                 445             


Leu Ala Asn Thr Xaa Xaa Phe Asp Xaa Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Xaa Glu Arg Ser Ser Ala 
            500                 505                 510         


<210>  2
<211>  513
<212>  PRT
<213>  Pseudonocardia thermophila

<400>  2

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Ser Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asp Lys Leu Gly Ala Trp Ala Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Ser Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Gly Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  3
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  3

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Ser Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Ala Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Ser Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Gly Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  4
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  4

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Ser Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asp Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Ser Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Gly Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  5
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  5

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Ser Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asp Lys Leu Gly Ala Trp Ala Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Ser Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  6
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  6

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Phe Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asp Lys Leu Gly Ala Trp Ala Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Ser Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Gly Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  7
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  7

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Arg Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asp Lys Leu Gly Ala Trp Ala Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Ser Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Gly Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  8
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  8

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Ser Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asp Lys Leu Gly Ala Trp Ala Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Ser Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ser Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  9
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  9

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Arg Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asp Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ser Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Cys Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  10
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  10

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Arg Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ser Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Cys Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  11
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  11

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Arg Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  12
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  12

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Ser Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Ser Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ser Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Cys Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  13
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  13

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


His Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Gly Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  14
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  14

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Arg Val Thr Gly Leu Leu Gly Ser Tyr Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Ile Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Phe Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Val Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu His 
        435                 440                 445             


Leu Ala Asn Thr Asp Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Pro Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  15
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  15

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Arg Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Ile Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Phe Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Val Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu His 
        435                 440                 445             


Leu Ala Asn Thr Asp Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Pro Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  16
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  16

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Tyr Val Thr Gly Leu Leu Gly Ser Tyr Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Ile Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Phe Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Val Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu His 
        435                 440                 445             


Leu Ala Asn Thr Asp Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  17
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  17

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Arg Val Thr Gly Leu Leu Gly Ser Tyr Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Phe Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Val Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu His 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  18
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  18

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Arg Val Thr Gly Leu Leu Gly Ser Tyr Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Ile Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Phe Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Val Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu His 
        435                 440                 445             


Leu Ala Asn Thr Cys Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Pro Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  19
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  19

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Tyr Val Thr Gly Leu Leu Gly Ser Tyr Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Ile Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Phe Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Val Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu His 
        435                 440                 445             


Leu Ala Asn Thr Asn Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  20
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  20

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Tyr Val Thr Gly Leu Leu Gly Ser Tyr Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Ile Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Phe Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Val Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu His 
        435                 440                 445             


Leu Ala Asn Thr Gln Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  21
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  21

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Tyr Val Thr Gly Leu Leu Gly Ser Tyr Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Ile Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Phe Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Val Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu His 
        435                 440                 445             


Leu Ala Asn Thr Glu Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  22
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  22

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Tyr Val Thr Gly Leu Leu Gly Ser Tyr Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Ile Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Phe Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Val Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu His 
        435                 440                 445             


Leu Ala Asn Thr Lys Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  23
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  23

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Arg Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Asn Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  24
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  24

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Arg Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Gly Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  25
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  25

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Arg Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Val Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  26
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  26

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Arg Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Asp Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  27
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  27

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Tyr Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  28
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  28

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Arg Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Ala Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  29
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  29

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Arg Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Pro Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  30
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  30

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Arg Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ser Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  31
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  31

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Arg Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Ile Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  32
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  32

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Arg Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Ile Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  33
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  33

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Arg Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Phe Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  34
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  34

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Arg Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu His 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  35
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  35

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Arg Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Arg Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  36
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  36

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Arg Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Gly Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  37
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  37

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Arg Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Arg Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  38
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  38

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Arg Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Arg Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  39
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  39

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Arg Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ser Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  40
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  40

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Arg Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Cys Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  41
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  41

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Arg Val Thr Gly Leu Leu Gly Ser Tyr Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asn Lys Leu Gly Ala Trp Tyr Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Ala Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  42
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  42

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Ser Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asp Lys Leu Gly Ala Trp Ala Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Thr Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Gly Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  43
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  43

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Tyr Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asp Lys Leu Gly Ala Trp Ala Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Ser Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Gly Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  44
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  44

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Ser Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asp Lys Leu Gly Ala Trp Ala Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Ser Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Ile Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Gly Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  45
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  45

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Ser Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asp Lys Leu Gly Ala Trp Ala Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Ser Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Gly Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Glu Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  46
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  46

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


His Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asp Lys Leu Gly Ala Trp Ala Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Ser Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Gly Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  47
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  47

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Ser Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asp Lys Leu Gly Ala Trp Ala Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Ala Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Ser Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Gly Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  48
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  48

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Ser Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asp Lys Leu Gly Ala Trp Ala Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Ser Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Gly Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Gln Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  49
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  49

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Ser Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asp Lys Leu Gly Ala Trp Ala Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Ser Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Val Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Gly Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  50
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  50

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Ser Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asp Lys Leu Gly Ala Trp Ala Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Ser Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Gly Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Cys Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  51
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  51

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Ser Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asp Lys Leu Gly Ala Trp Ala Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Ser Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Gly Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Lys Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  52
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  52

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Ser Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asp Lys Leu Gly Ala Trp Ala Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Ser Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Gly Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ser Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  53
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  53

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Ser Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asp Lys Leu Gly Ala Trp Ala Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Ser Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Gly Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Asn Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  54
<211>  513
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  54

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Ser Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asp Lys Leu Gly Ala Trp Ala Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Ser Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Gly Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Pro Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  55
<211>  513
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  55

Met Ser Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala 
1               5                   10                  15      


Glu Gly Arg Phe Gly Ile Pro Glu Ser Asp Leu Pro Thr Tyr His Ala 
            20                  25                  30          


Ser Val Thr Gly Leu Leu Gly Ser Trp Asn Lys Val Glu Glu Leu Tyr 
        35                  40                  45              


Ala Glu Val Ala Pro Thr Pro Pro Gln Arg Ser Trp Thr Arg Pro Asp 
    50                  55                  60                  


Ala Glu Asp Asp Lys Leu Gly Ala Trp Ala Val Gln Thr Ser Ile Thr 
65                  70                  75                  80  


Glu Thr Ser Glu Gly Pro Leu Ala Gly Arg Thr Val Ala Val Lys Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Pro Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Ser Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Ile Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met Asn Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Gly Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Asn Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glu Arg Ser Ser 
            500                 505                 510         


Ala 
    


<210>  56
<211>  509
<212>  PRT
<213>  Pseudonocardia thermophila

<400>  56

Met Ile His Met Pro Asp Pro Asp Ala Val Ala Arg Met Ala Ala Glu 
1               5                   10                  15      


Gly Arg Phe Gly Ile Pro Val Val Val Ile Cys Arg Thr Tyr His Asp 
            20                  25                  30          


Leu Gly His Arg Pro Ala Arg Leu Val Glu Gln Gly Arg Arg Ala Val 
        35                  40                  45              


Arg Gly Gly Gly Pro His Pro Ala Ala Ala Leu Val Asp Pro Pro Arg 
    50                  55                  60                  


Arg Arg Gly Arg Gln Ala Arg Arg Val Gly Gly Ala Asp Leu Asp His 
65                  70                  75                  80  


Arg Asn Leu Gly Gly Ala Ala Arg Arg Pro His Gly Arg Gly Gln Asp 
                85                  90                  95      


Asn Val Ala Val Ala Gly Val Pro Met Met Asn Gly Ser Arg Thr Leu 
            100                 105                 110         


Glu Gly Phe Val Pro Ala Glu Asp Ala Thr Val Val Ser Arg Leu Leu 
        115                 120                 125             


Ala Ala Gly Ala Thr Ile Ala Gly Lys Ser Val Cys Glu Asp Leu Cys 
    130                 135                 140                 


Phe Ser Gly Gly Ser His Thr Ser Lys Pro Gly Thr Val His Asn Pro 
145                 150                 155                 160 


Trp Asp Met Ser Arg Ser Ala Gly Gly Ser Ser Ser Gly Ser Gly Ala 
                165                 170                 175     


Leu Val Ala Ala Gly Glu Val Asp Met Ala Ile Gly Gly Asp Gln Gly 
            180                 185                 190         


Gly Ser Ile Arg Ile Pro Ser Ala Tyr Cys Gly Thr Val Gly His Lys 
        195                 200                 205             


Pro Thr His Gly Leu Val Pro Tyr Thr Gly Gly Phe Pro Ile Glu Gln 
    210                 215                 220                 


Ser Ile Asp His Leu Gly Pro Ile Thr Arg Thr Val Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Met Leu Ser Val Ile Ala Gly Arg Asp Gly Leu Asp Pro Arg Gln 
                245                 250                 255     


Pro Asp Val Val Glu Val Gln Asp Tyr Val Gly Ala Leu Ala Glu Ser 
            260                 265                 270         


Val Ser Gly Leu Arg Ile Gly Val Leu Gln Glu Gly Phe Gly His Pro 
        275                 280                 285             


Asn Ser Glu Pro Glu Val Asp Asp Thr Val Arg Ala Ala Val Gly Thr 
    290                 295                 300                 


Leu Arg Glu Ala Gly Phe Thr Val Glu Asp Val Ser Val Pro Trp His 
305                 310                 315                 320 


Leu His Ala Thr Ala Ile Trp Asp Val Leu Ala Thr Glu Gly Gly Leu 
                325                 330                 335     


Trp Gln Met Val Glu Gly Asn Ala Tyr Gly Met His Trp Lys Gly His 
            340                 345                 350         


Tyr Asp Pro Ser Leu Ile Ala Tyr Tyr Gly Arg Lys Trp Arg Glu Asp 
        355                 360                 365             


Pro Ala Gln Phe Ser Glu Thr Val Lys Leu Val Ala Leu Ala Gly Arg 
    370                 375                 380                 


Tyr Ala Leu Thr Thr Gln Tyr Gly Arg His Tyr Ala Met Ala Arg Asn 
385                 390                 395                 400 


Leu Ala Pro Lys Leu Val Ala Ala Tyr Asp Ala Ala Leu Ser Asn Tyr 
                405                 410                 415     


Asp Val Leu Val Met Pro Thr Leu Pro Met Arg Ala Thr Val Leu Pro 
            420                 425                 430         


Gly Pro Asp Ala Pro Val Glu Glu Ile Leu Ala Arg Gly Leu Glu Met 
        435                 440                 445             


Leu Ala Asn Thr Ala Pro Phe Asp Val Thr Gly His Pro Ala Cys Ser 
    450                 455                 460                 


Val Pro Ala Gly Leu Ala Asp Gly Leu Pro Val Gly Leu Met Ile Val 
465                 470                 475                 480 


Gly Lys His Phe Asp Asp Ala Thr Val Leu Lys Val Ala Asn Ala Phe 
                485                 490                 495     


Glu Gln Ala Val Gly Gly Phe Pro Thr Pro Ala Ala Glx 
            500                 505                 


