                         SEQUENCE LISTING

<110>  Boehringer Ingelheim International GmbH
       Medizinische Hochschule Hannover
 
<120>  Myeloid-derived growth factor for use in treating or preventing 
       fibrosis, hypertrophy or heart failure

<130>  750-3 PCT

<150>  EP20153008.6
<151>  2020-01-21

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  1

Val Ser Glu Pro Thr Thr Val Ala Phe Asp Val Arg Pro Gly Gly Val 
1               5                   10                  15      


Val His Ser Phe Ser His Asn Val Gly Pro Gly Asp Lys Tyr Thr Cys 
            20                  25                  30          


Met Phe Thr Tyr Ala Ser Gln Gly Gly Thr Asn Glu Gln Trp Gln Met 
        35                  40                  45              


Ser Leu Gly Thr Ser Glu Asp His Gln His Phe Thr Cys Thr Ile Trp 
    50                  55                  60                  


Arg Pro Gln Gly Lys Ser Tyr Leu Tyr Phe Thr Gln Phe Lys Ala Glu 
65                  70                  75                  80  


Val Arg Gly Ala Glu Ile Glu Tyr Ala Met Ala Tyr Ser Lys Ala Ala 
                85                  90                  95      


Phe Glu Arg Glu Ser Asp Val Pro Leu Lys Thr Glu Glu Phe Glu Val 
            100                 105                 110         


Thr Lys Thr Ala Val Ala His Arg Pro Gly Ala Phe Lys Ala Glu Leu 
        115                 120                 125             


Ser Lys Leu Val Ile Val Ala Lys Ala Ser Arg Thr Glu Leu 
    130                 135                 140         


<210>  2
<211>  142
<212>  PRT
<213>  Mus musculus

<400>  2

Val Ser Glu Pro Thr Thr Val Pro Phe Asp Val Arg Pro Gly Gly Val 
1               5                   10                  15      


Val His Ser Phe Ser Gln Asp Val Gly Pro Gly Asn Lys Phe Thr Cys 
            20                  25                  30          


Thr Phe Thr Tyr Ala Ser Gln Gly Gly Thr Asn Glu Gln Trp Gln Met 
        35                  40                  45              


Ser Leu Gly Thr Ser Glu Asp Ser Gln His Phe Thr Cys Thr Ile Trp 
    50                  55                  60                  


Arg Pro Gln Gly Lys Ser Tyr Leu Tyr Phe Thr Gln Phe Lys Ala Glu 
65                  70                  75                  80  


Leu Arg Gly Ala Glu Ile Glu Tyr Ala Met Ala Tyr Ser Lys Ala Ala 
                85                  90                  95      


Phe Glu Arg Glu Ser Asp Val Pro Leu Lys Ser Glu Glu Phe Glu Val 
            100                 105                 110         


Thr Lys Thr Ala Val Ser His Arg Pro Gly Ala Phe Lys Ala Glu Leu 
        115                 120                 125             


Ser Lys Leu Val Ile Val Ala Lys Ala Ala Arg Ser Glu Leu 
    130                 135                 140         


<210>  3
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Ala Pro Ser Gly Gly Trp Asn Gly Val Gly Ala Ser Leu Trp 
1               5                   10                  15      


Ala Ala Leu Leu Leu Gly Ala Val Ala Leu Arg Pro Ala Glu Ala Val 
            20                  25                  30          


Ser Glu Pro Thr Thr Val Ala Phe Asp Val Arg Pro Gly Gly Val Val 
        35                  40                  45              


His Ser Phe Ser His Asn Val Gly Pro Gly Asp Lys Tyr Thr Cys Met 
    50                  55                  60                  


Phe Thr Tyr Ala Ser Gln Gly Gly Thr Asn Glu Gln Trp Gln Met Ser 
65                  70                  75                  80  


Leu Gly Thr Ser Glu Asp His Gln His Phe Thr Cys Thr Ile Trp Arg 
                85                  90                  95      


Pro Gln Gly Lys Ser Tyr Leu Tyr Phe Thr Gln Phe Lys Ala Glu Val 
            100                 105                 110         


Arg Gly Ala Glu Ile Glu Tyr Ala Met Ala Tyr Ser Lys Ala Ala Phe 
        115                 120                 125             


Glu Arg Glu Ser Asp Val Pro Leu Lys Thr Glu Glu Phe Glu Val Thr 
    130                 135                 140                 


Lys Thr Ala Val Ala His Arg Pro Gly Ala Phe Lys Ala Glu Leu Ser 
145                 150                 155                 160 


Lys Leu Val Ile Val Ala Lys Ala Ser Arg Thr Glu Leu 
                165                 170             


<210>  4
<211>  166
<212>  PRT
<213>  Mus musculus

<400>  4

Met Ala Ala Pro Ser Gly Gly Phe Trp Thr Ala Val Val Leu Ala Ala 
1               5                   10                  15      


Ala Ala Leu Lys Leu Ala Ala Ala Val Ser Glu Pro Thr Thr Val Pro 
            20                  25                  30          


Phe Asp Val Arg Pro Gly Gly Val Val His Ser Phe Ser Gln Asp Val 
        35                  40                  45              


Gly Pro Gly Asn Lys Phe Thr Cys Thr Phe Thr Tyr Ala Ser Gln Gly 
    50                  55                  60                  


Gly Thr Asn Glu Gln Trp Gln Met Ser Leu Gly Thr Ser Glu Asp Ser 
65                  70                  75                  80  


Gln His Phe Thr Cys Thr Ile Trp Arg Pro Gln Gly Lys Ser Tyr Leu 
                85                  90                  95      


Tyr Phe Thr Gln Phe Lys Ala Glu Leu Arg Gly Ala Glu Ile Glu Tyr 
            100                 105                 110         


Ala Met Ala Tyr Ser Lys Ala Ala Phe Glu Arg Glu Ser Asp Val Pro 
        115                 120                 125             


Leu Lys Ser Glu Glu Phe Glu Val Thr Lys Thr Ala Val Ser His Arg 
    130                 135                 140                 


Pro Gly Ala Phe Lys Ala Glu Leu Ser Lys Leu Val Ile Val Ala Lys 
145                 150                 155                 160 


Ala Ala Arg Ser Glu Leu 
                165     


<210>  5
<211>  12847
<212>  DNA
<213>  Homo sapiens

<400>  5
acgtgtccct cgccgcgccc cgtctacccg cccctgccct gaggacccta gtccaacatg       60

gcggcgccca gcggagggtg gaacggcgtc ggcgcgagct tgtgggccgc gctgctccta      120

ggggccgtgg cgctgaggcc ggcggaggcg gtgtccgagc ccacgacggt ggcgtttgac      180

gtgcggcccg gcggcgtcgt gcattccttc tcccataacg tgggcccggg ggtacgtgcc      240

accgccgtcc cggatatttg agtgctggca ggcccgggga gggggcgcgg agcattgggg      300

gcggggcccg aggagggggc gcggaccgcg gaggtgggta ctgaagaagg ggtgcggatt      360

gttagggtcg gaggctgagt ggggggcgcg ggaccgtgag gccggggtca tcactggggc      420

aggactgaac tcatagggag cggggccttg tgggccccgg cggcgttgag ggggcgtgat      480

cacctgtcac ctgtcgcctg cctggagtgt ccaggcaccc ctgccctcca gacgcagagg      540

tggggagggg tcagtgatgg gagcggcagg aggctaaagg gcatctgccc tcctgggcct      600

gaaggaaatc agtcgctgca gctccgaaga gggaggaagt gctccttcct tccattgcac      660

aaggtccccc ctcaccgagg gtgtgaggcc gggccctcag ccctgtactc agcttgtcgg      720

caaagtcctt tcccctctca gcctcccttt ccccgcctgt aataacagta tctttactgt      780

tttttgacta tttcttttta gacttgcgtg cagtggcggg atctcggctc actgcatcct      840

tagccttctg ggttcaagca attcttctgc ctcagcctcc ccagtacctg ggattacaga      900

cgtgtgccac cacacccgga taattgttgt tgttgttgtt tgagatggag cctcactctg      960

tcgcccaggc tggagtgcag tggcgcgatc ttggctcact gcaacctctg cctcccaggt     1020

tcatgccatt ctcctgccgc agcctcccaa gtagctggga ctactaatct ttgtattttt     1080

agtacagatg ggatttcacc atgttagcca ggctggtctt gaactcctga ccgcaggtga     1140

cccgcccacc tcggcctccc aaagtgatgg gattacaggc gtgagccact gtgccaggcc     1200

agtttgttga ctacttcctt atagttaggt gtgatgccaa gtcctttata tgttaggccc     1260

aagttacaga tgagaaaatg cttcacataa aaaagagaaa cagagagaaa ctagaggctc     1320

agaaaagttt tcacttgtcc aggtcccatg gcaaaaccca tctctacaaa aatacgaaaa     1380

attagccagg tgtggtagca ggtgcctgta atcccaagta ctcaggaggc tgaggcagga     1440

gaatcgtttg aacccgggag gcagaagttg cagtgagctg agatcatccc acttcagcct     1500

gggcgacaga acaagactct gcttcaaaaa aaaaaaaaaa aattagtcgg gtgtggtggt     1560

tgcgtaccta ttgtctcagt tacttgagag gctgaggcaa gaggattact caaacctggg     1620

agttcgaggc tgcagtgagc tgtcattgtg cccctgcact ccagcttggg tgacagcaag     1680

accccgtctc ttaaacaaaa taaaaatttc cttctaccaa accttttttt tccttccatt     1740

ctctaggaca aatatacgtg tatgttcact tacgcctctc aaggagggac caatgaggtg     1800

agttgttcaa aattccctct agcttactgt gacagtatcc attgttgtag ggagatgttc     1860

tgtagcagac agcagggttg ggtctcacct atatcacctt acactcattg aatgactctt     1920

cctaaaccaa taaaaaggga gagtattggc attaaacagt gacgacagat tctgctgtta     1980

ttattctaca gagcaagcaa atgtctggac agaaggaggg aggggagatg ggagtctgcc     2040

atccccatga gcatctgttg ggatgttgta ttttatgtgc agtgcaacaa gttatcacag     2100

cttaggggct taaaacagca cccatttatt atctcatagc tttgtaggtc agaagtctgg     2160

gtcagctcag ttgtgtgctt cataaaacca aactcaaggt attttgggag gctgaggcgg     2220

gcagatcacc tgaggtcaaa gttcgagacc agcctggcca acatggcaaa acctcatctc     2280

tactaaaaat acaaaaatta gctgggcatg gtggcacatg cctgtagtcc cagctactca     2340

ggaggctgag gcaggagaat cacttgaacc caggagacgg aggttgcagt gagccaagat     2400

tgtgccactg cactccagcc tgggcaacag agcgagactc tgtctcaaaa aataaataat     2460

aaataaataa aggtatcaca ggcaaggcat ggtggctcat gccccatctc tacagaaaat     2520

aaaaaaatta gcccagcgtg gtggcgtgca cctgtggttc cagctacttg ggagactgag     2580

gtgggaggat cgcttgagcc caggaggtca aggctgtagt gagccgtgat tgtgctactg     2640

ggcaacagag caagaccctg tctcaaaaaa aaaaaaagtc tctgggctgg gagaagaatc     2700

ctctccttca agctcttagt tggcagaatt cagttacttg tggttcaggg accaaggtcc     2760

cggtttcctt gctggctgtt gtctccagct ggtggcagaa gagccagtaa agatgatttg     2820

ggccaggcac agtggctcat gcctataatc ccagcacttt gggaggccaa ggctggcgaa     2880

tcacctgaag tcaggagctc cagaccagcc tggccaacat ggtgaaaccc cgtctctact     2940

aaaactacaa aaattagccg ggcgagccag gcgcactggc tcatgcctgt aatcccagca     3000

ctttgggagg ccgaggcggg tggatcacaa ggtcaggaga tcgagaccat cctggctaac     3060

acggtgaaac cccgtctcta ctaaaaatac aaaaaattag ccgggtgttt tggtgggcac     3120

ctgtagtccc agctactggg gaggctgagg caggagaatg gcgtgaaccc gggaggcgga     3180

gcttgcagcg agccaagatc gcgccactgc actccatcct gggcgacaga gcgagactct     3240

gtctcaaaaa aaaaaaaaaa aaaaaaaaaa gggtgatttg aagcacatgg acacatacgc     3300

cactgctgcc cttgagggaa ctgcagggca gggaatacac gcggcctcta ggagctgaga     3360

acagcctctg gctggcagca aggaaatgaa gacttcagtc ccgcaaccaa gaggaactga     3420

aatctgccac aaccacaaga gcttggaaga ggaccttgag ctaccagtaa gagcctagcc     3480

cggtcaacac cttgagatgg gtttcgccat gttggccagg ctgatcttga actgctgacc     3540

tcaaatgatc agcctgcctc ggcctcccaa agtgctggga ttacaggtgt gagccaccgg     3600

tgcccggcct cctagagatt tttctgtatc ctatgtaaag cgcttcagtt gcatggacgt     3660

gtggagttga caatcccgta ctaatggatt gagggttact tccaacccag tccgtgaata     3720

accttggcca gggttcattg tacaagtgca gttacatctg tgggaaaacc acccagaagt     3780

gggattcatg ggtccatttt cttaaaagta aaactgggct gggcgcggtg gctcacgcct     3840

gtaatcccag cactttgaga ggccaaggca ggtggatcgc ctgaggttgg gagtttgaga     3900

ccagccttgc taagatggtg aaaccccatc tctactgaaa atacaaaagt tagcagggcg     3960

tggtggcacg cgcctgtaat cccagctact caggaggctg aggcaggaga atcgcttgaa     4020

cccacgaggc agaggttgca gtgagctgag atcgcaccac tgcactccag cctgggtgac     4080

agagcgagac tccatctcaa aaaaaaaaaa aaaagtaaaa ctgtatgttt tgagatcatg     4140

gtagatttac attcacttgt aagaaatcct acagagagat ccaagtaccg tttaaccagg     4200

ttccccggtg gtaacatcgt gcaagaggcc agtcatttta gagatggggt ctcgctatgt     4260

tgcccaggct ggtctcgaac tcttgggttc aagtgatcat cccacgttgg cctcccaaag     4320

tgctgggatt acaggcatga gccaccatgc ccagcctgca ttttccattt tgcttgtacc     4380

tgttgcagct ccaccgacaa cctggaatag tcttggtttt cacacccata tggtgtgtta     4440

gcagacagga gggcttttgc ccttctgacc tgggagaaaa aggtatctca cgatagttca     4500

gcttgtgttt atttattttt cataaatgat atgggacatc tttttttttt tttttttttt     4560

tttttttttt tgagacagag tctcgctctg tcgcccaggc tggagtgcag tggcgcgatc     4620

tcagctcact gcaagctccg cctcccgggt acacgccatt ctcctgcctt agcctcccga     4680

gtagctggga ctacaggcgc ccaccactgc gctcggctaa ttttttgtat ttttagtaga     4740

gatggggttt catcatgtta gccaggatgg tcttgatctc ctgacctcgt gatctgcctg     4800

cctcggcctc ccaaagtgct gggattacag gcgtgagcca ccgcgcccgg cctggacatc     4860

tatttatatg tttaagagtt gttcttaggc ctggcatggt ggcttatatc tgtaatctca     4920

gcactttggg aggccaaggt gggaggattg cttgaggcca ggaggttgag accagcctgg     4980

gcaatatggc aagacagtga ttctacaaaa cacaaaaatt agctgggtgt ggtcccagct     5040

acttgggagg ctgaggtggg aggatcgctt gagcccagga ggtagaggtt gcagtgaggc     5100

gagatcgtgc cactgcacgc cagcccaggc cacagagaga gactccatct caaaaacaaa     5160

caaacaaaca aacaaacagc gttgttccta tttccccatc cgtgggagcc actttggggt     5220

agttctcatt agaggcacca cttttatggg aaggatgtgg tgcaggcagg ctccctgatc     5280

acagatgaca gcaaacccca ggccaccagg agggcggggc aggggattta gtggccagcc     5340

cctgaatcgg gaggtacaga agaggtggcc tgactgtaga atcagaggca cacctagaag     5400

tctccgagag cagctgtgtg tccggggctg acccgcgctg tcttctctcc ccagcaatgg     5460

cagatgagtc tggggaccag cgaagaccac cagcacttca cctgcaccat ctggaggtga     5520

gactcggggt ggggatggca tttccggctg ccgttggcct gccctgtggc ctcaggagct     5580

gctttggaag gcagggaacg agggctgcac ccctggaggg gaagacagac cagcagggag     5640

actcatgcac gtgcaggtgg ggggtggcag ggtcgctggg gtgggagtgc tccccaagga     5700

agtgcactga tgcagagact gagaaggtct gggggagacg gggggagcct gtgcggggca     5760

aggtcccagg aaaaggagaa gcagctcaga gggtgcggag cgtggaccag ggcccaggaa     5820

ggccccaagg ggctccaccc tcccctaagg gtgagacgaa ctcaccaaag ggctttttgg     5880

caattttttt tttttttttt ttgagatgga gtctccatct tttgcccggg ctgtagtgca     5940

gtggagcaat cttggctcac tgcagcctcc gcctcctggg ttcaagcgat tctcctccct     6000

cagcctcctg agtagctggg attacaggcg tgtgccacca tgcctgaccc tttttggcaa     6060

tgtttaaaaa ctgagataaa attccataaa gcacagcatt ttaagctcac aattcagctg     6120

catggagtac tttctcagag gtgtgcagcc agacctctgc ttccagaaca ttttcatccc     6180

ctgaaaataa actctgttcc catcagagtc attctccttc ccagcacatg gcagccacgc     6240

atccccctcc tgtctctgtg gatgggcgtg tcctggacat tgcatagaaa tggggtcaaa     6300

ccttccctgt gtggcctttg gtgtctggcg tctctcactg aacgtgacgt cctcaaggct     6360

catccatgct gaggcccgtg tcagcctcat ttcttttcct ggctgagtcc tattccagag     6420

ggctccctgc aggaacatgt ggagctcaga tccccccggc tgaaggaggc aggctgaggc     6480

agggagcccc tccaggcacc aaccaggatg gagtcggggg ttgggggtgg ggcgcagatt     6540

gaagcctgtg cagaatgagg atggggtggg tggagagggc acagattgga ggctgtgtag     6600

aatgaggatg gggtgggtgg ggagggtaga ttggaggctt tgtagaatga ggatggggtg     6660

ggtggggaga gcacagattg gagactgtgt agaatgagga cagggtgggt ggggagggta     6720

tactggaggc tgtagaatga ggatgaggtg gggagggtag attggaggct gtagaatgag     6780

gatggggtgg gtggggaggg tagattggag gctgtgtaga atgagggtgg ggtgggtggg     6840

gaggatagat tggaggctgt gtagaatgag gatggggtgg gtggagagtg cacaggttgg     6900

aggctgtaga atgaggatgg ggtggggagg gtagattgga ggctgtgtag aatgaggatg     6960

gggtgggtgg agagggcaca gattggaggc tgtgtagaat gaggatgggg taggtgggga     7020

gagtagattg gatgctgtag aatgaggatg gggtggatgg gagcgtagat tggaggctgt     7080

gtagaatgag gatgggatgg gtggagaggg cacagattgg aggctgtaga atgaggatgg     7140

ggtgggtggg gagggtagat tggaggctgt gtagaatgag gacaggacgg gtggggaggg     7200

tagattggag gctgtgtaga atgaggacag gacgggtggg gagggtagat tggaggctgt     7260

agaatgagga tgaggtgggt ggggaatgta gatcggaggc tgtagaatga ggatggagtg     7320

gggtggggag agtagattgg aggctgtaga atgaggacgg agtgggaggg gaaggcacag     7380

actggaggct gtgtaaaatg aggacaggga ggaggggagg gcacagattg gaggctgtgg     7440

aatcagctag ctggggtagg aggaggagga aggtgctggg cagagtcctg gtggaactgg     7500

cggagctggt gcaggtctgg gctggggacg agctaggcag gtggcaggtg tgggagtctg     7560

tggggtagtg gctgtggagg tttggatgat gctatctccc ggggaatgtg tcccaccaga     7620

aggggcccca gctgtttccc ctcaggcagg tctttaccag catgttctct gaaggaccag     7680

cctgatggct catagccttc ttggggtgca gacatctggg aatcagacaa aagctgtgca     7740

ctctcttcca cctgcccgaa cacacatgca tctgggtcca cagcccctcc ccaagtctcc     7800

ccagacaccg cccgattctg cccctgccgc catcctctgt caggctcatg gtttatgggc     7860

ttatcccggc tccactcgcc ccactcattc tcgtaacccc actgcctaga tcccagctcg     7920

atctgggcaa ggtcatgaag ggaaggaagc cgtcaggccc cccggtgggg agggggtcgg     7980

gggcttcagg aatcttgtcc cttcttccct gatccttggc ccagaatgtc tcagcccaaa     8040

cagtgggtat ttcttgagcc tttattttgt gcagacactt tggagggaga agtccaagct     8100

atagctccac cactgcggtc aggttaaagc acgttgacaa atgggaggca gagatcaggg     8160

agtggcgacg tttaactgaa ggacagggtg tgatttgctg cctcgtgtgg gtgttgtccc     8220

gccgtgccct gcggggcgct ttacaaacag caggtgtttc tggggagatt ctcacccact     8280

ccatggaact ggctgcatca caggcaggcc aaggccccag gaggcatcag gagggtcatt     8340

gagaggagat aggccccatc agcccagaga gaccctgcag aggccgccct gtagtcttgg     8400

ggaagcccac ggtcgccatc gtctgtctgc aggccactgc cctgcatgga cccctgagtg     8460

ccagctcccc agagggcatc tgggcaggtg caggtctgga gcagttggga tggtggctgg     8520

gctcaccttg agcctgaatc ctcctgtcca acccccacaa aagctcccca ggggcatgct     8580

cagccccgga gacctgccac cccaggcctc ctcatctcag acagtgactg gaccctccct     8640

gaccagggct gttggcagtg ctagggctta aagaagaatc tagggctccc tggatacccc     8700

cgccccaccc atgcacatag aaccccagcc agggcttcca cagaaatggc ccccctgctg     8760

cccctccatc cccatcacac tctcttcaca ccagagatgc catcatcccc tgctgtcacc     8820

ttccgacacc ttctgccact ccagttcctt agaagcctcc gttagcagcc ttctagagac     8880

ctgggcagat gatcctcccc acttcttaag ttaactcctg tacttcctag tcaatgccct     8940

ctgagaagcc tttactggcc tctcattgcc cagccccagc ccccgtcgta gtacctggat     9000

tgctgtcagc aaccaagaag ccatgtgcag tgaatggaca tggggtcctg tcccagagca     9060

gctcccagcc cacaggggag agaggcgtgt ctatgaatga gctggaagaa cattctggca     9120

caaaggggcc aggcacagtg gctcacacct ctaatcacag ccctctggga ggctgaggcg     9180

agtggatcac ttgaggtcag gggttcaggc caggctggcc aacatggtga aaccatgttt     9240

ttactaaaaa taccaaaatt agtcagatgt ggtcgcgggt gcctgtactc ccagctacaa     9300

gggaggctaa ggcaggagaa tcacttaaac ccaggaggca gaggctgcag tgagtgagat     9360

tgtgccattg ccatccagcc tgggcaacag agtgagactc gtctccaaaa aaaaaaaaaa     9420

aaaaaaattc tggcacaaaa gaaagagggt ctgctgttga gagggcccca tccatccttc     9480

ccagtcagca ggtgctcgtg ctcgggaatg gcgtccatgt tgagaagcag gcacgagacc     9540

tgctgacccc agcccgagtc cctggcgggg ctccttccag ggcacacaga cccagaccca     9600

gcaggcctgg cctgactccc tcgccccctc ttcctctgca ggccccaggg gaagtcctat     9660

ctgtacttca cacagttcaa ggcagaggtg cggggcgctg agattgagta cgccatggcc     9720

tacgtgagta tcttggagtg gggcaggctc cgggtgtggc ttctgtgcac tggggcagct     9780

gtgagatgtc ctgccacaag agggctccat ggggacaggg aggagagggg acagcgaatc     9840

ctgcagaggt agggtgtgta acttgcagga acctggcaca cagacgcccc caggccaggg     9900

gcacgggggt ttggtaacct gttgctgctg gcttctcttg tatatgccag aaaagacttc     9960

tccaggccag gcgcggcggt tcacgccagt aatcccagca atttgggagg ctgaggcagg    10020

aggattgctg gaggccagga atttgattcc agcctaggca acatagcaag accctatatc    10080

taccaaaagt aaaaaaaaaa tagccaggcg tgttggcatg cacccatagt cccacctact    10140

caggaggccg cagcaggagg atcacttgag tccaggactt tgaagctgca gtgagctatg    10200

attgcactgc tgcattccag cctggacagt agagtgaggt cctggctcaa aaacaaaaaa    10260

gtctcctctc catctctagt aaaagtagaa agctttagtc tgtgcttctc tggaaagcaa    10320

actcaatcgt tttcctaatg atgagcattg aactggccct ggtaaagttt ccactcattc    10380

tttttcagtc taaagccgca tttgaaaggg aaagtgatgt ccctctgaaa actgaggaat    10440

ttgaagtgac caaaacagca ggtacggaaa gatggggatg gggtagaggt gacgccaccc    10500

ccatccaagg gtgggcaatc ggggcagttt ggagaggggg gtcagccata ggggtcctgg    10560

agactgtaga ccaggcatcc acaaactgat tctataaagg ccacctcgtc aatatcttca    10620

gctttgtggc actgtgggtt ctgtctagag ctgtgccatt gtggcacaaa gctgctgcag    10680

acagtatgtc catgcgtggg tgtggctgtg tgccactaga actttatctt agctgggcgc    10740

ggtggctcat gcctgttacc gcagctgctc aggaggctaa ggtgggagga tcattggagc    10800

ccaggaggtc aagaccagcc tgggcaacat agcgagaccc tgtctctaca aaattttttt    10860

aaaaatcagg ctgggtgcgg tggctcacgc ctgtaatccc agcactttgg gaggacgagg    10920

cgggcggaac acttgaggtc aggagttcca gaccagctgg ccaacataat gaaaccccat    10980

ctctactaaa aatgcaaaaa attagccagg cgtggtggtg cgcacctgta atcccagcta    11040

ttcaggagaa ttgctggaac ctgggaggtg gaggttgcag tgagctgaga tcatgccact    11100

gcactctagc ctggaagaca gcaagattct gtctcaaaaa gaaaaaaaat tagccgggca    11160

tggtggtgtg tacctgtagt ctcagctact taggaggctg aggtgggagg attatttgag    11220

cccaggaggt cgaggctgca ttgagctatg atcgcaccac tgcactccag cctgggcatc    11280

agagtaagac tctgtctcaa aaacaataaa cagggctggg catggtggct cacacctgta    11340

atcccagcac tttgggaggc caggagttcc agaccagcct agccaacatg gtgaaacccc    11400

ttctctacta aaaataccaa aattagccaa ggatggtggc acatgcttgt aatcccagct    11460

actcaggagg cagagacagg agaatctctt gaacttagga gcaggaggtt gcagtgagtc    11520

gagactgcac cactgcactc cagcctaggc aacagaggaa gactctcatc tcaaaaaaaa    11580

taataaattt taaaaaataa ataaatgaaa taaaacaaag tagaaaccat cagggctttg    11640

aggttgggac tgtggcatgc cgaggggagg ctgcaggggt cactgggaaa catcagggtc    11700

cttcttcggt tgcctgagca gcaccggtgt cctcaagcca cattcagctg catggcgcca    11760

atgctaagca gaaagaggaa tcggaggcgc cgagctgggg caagggtggg agccaaggga    11820

gtggacacag caggtagggc cgggagactt gggtgaagca gtggaagcca gagttctgac    11880

cctgctggag aagtgtcatg agggcctcag acaggttcac ccactgagca ggaggtcttg    11940

cagcctgacc caccctgcat cctgttcagg ccgggatcat ctccttcctg ggcttcttct    12000

ggcccctttc tgcatctctt cttgacaaca tggcacaaat gaccagggtt cttcccacct    12060

caggtctttc tgtggcttcc tgctgcctgc catctatgtt agccccaccg accttaccct    12120

ccacatcact gttttcctgt ctgtcacccg taagactttc agtgcctggg gccttttcac    12180

atgggagtct gctttggaga ctgctcccct tgcctgctta gcccccacca tgggccccac    12240

cccaaatcct ccggacttct gagaattttc aatgttgagg gcccaaccat gtgtttcttt    12300

cttgcagtgg ctcacaggcc cggggcattc aaagctgagc tgtccaagct ggtgattgtg    12360

gccaaggcat cgcgcactga gctgtgacca gcagccctgt tgcgggtggc accttctcat    12420

ctccggtgaa gctgaagggg cctgtgtccc tgaaagggcc agcacatcac tggttttcta    12480

ggagggactc ttaagttttc tacctgggct gacgttgcct tgtccggagg ggcttgcagg    12540

gtggctgaag ccctggggca gagaacagag ggtccagggc cctcctggct cccaacagct    12600

tctcagttcc cacttcctgc tgagctcttc tggactcagg atcgcagatc cggggcacaa    12660

agagggtggg gaacatgggg gctatgctgg ggaaagcagc catgctcccc ccgacctcca    12720

gccgagcatc cttcatgagc ctgcagaact gctttcctat gtttacccag gggacctcct    12780

ttcagatgaa ctgggaagag atgaaatgtt ttttcatatt taaataaata agaacattaa    12840

aaagcaa                                                              12847


<210>  6
<211>  7380
<212>  DNA
<213>  Mus musculus

<400>  6
gagcgcctgc gcattgcccc ggaagcaaga tggcagcccc cagcggaggc ttctggactg       60

cggtggtcct ggcggccgca gcgctgaaat tggccgccgc tgtgtccgag cccaccaccg      120

tgccatttga cgtgaggccc ggaggggtcg tgcattcgtt ctcccaggac gtaggacccg      180

gggtacgtgc taagcctcct gcccgggaat cgatgcctat ggacttccga tcaggtggtc      240

ctggagaccg ggtggagtgg cagaggcagg gttacctgaa gaagggacct ggctgcctcg      300

tctgtcttct gtcagtcact ccctacctgc aaggcgactt ccccttgccc atctcattgt      360

agaaaaggga atactggttg ataagagcag cggatctagg ggactggcta tacaggtcgc      420

acgtgggtta ctcactgaac ccggactaga gcgggagcac cccccaagcc ttacacgagt      480

ccatcacctc tcctttcagc gagccagcag tcagcctagc ctctgcccgc cccagcttgg      540

cttctgggac agcggtgtcc ctagtgacca tttcttgaga ccattactat agtcctgtgc      600

tttctggcag gtttgtgttg tgggcaggaa gcagtacaag cttgtatcta acaggagccc      660

cgagtactga cctcataggt gatgttctag ggatgattgc tgaaggccat ttgaccttcc      720

taggaaatca cagtgatttg agcaaagttc tgagctcctg agaggagaga gatctggtgg      780

cctctggagg gtgtactgag ggatggaacc tagagtctca catcggcaga gccagggttc      840

tgccccgccc taggcagggg ctccacccct gagccacatc cctagctcct cattagggga      900

ttctaggtgg gactccaccc ctgagtcacc ctcccaaccc ctcactgctg gattctggac      960

aggctcaacc cttgaccttc tgggcagggg ctgatgtata tctcagtcct ttttgatctg     1020

ttttacatcg ggacagcacc ttgctaagtc acccaggcta gcttatgtcc cagttcccag     1080

ttctgcgtca gcctcctgga taccagagat gatgtgcata caggaccatg cccagtatgc     1140

tagggtcttg gttctgagta ttgagatctt tgctcttcag cctcctttta tttctccttc     1200

tacagaacaa gtttacatgt acattcacct acgcttccca aggagggacc aacgaggtaa     1260

gttcctcagg gtgtcacacg actggtgtca agggaaagtg gccagactcc cgaggctcta     1320

aagtcccagt cccttgagcc tgaaggactt ctagttgcct tggcttccgc ctaatggaat     1380

cagcagccca cagtgctgat ccctgactct tagtctatgt gtaatcagtg agccaccaga     1440

gcctgggaca gtcctcaggg cagcccgtaa gctggcaaga gggccgatac ctcagcagca     1500

cccagggcat cgaggtgaac tgttatgagg ttagctgcct gtcccacaca caagttagtt     1560

cattcagtgg aaatactggt gtatccagaa ccttggacat gcatgttctg agcagagctt     1620

tccataggag caatgagtgg aagtgtctta gtgtccacgg atgggcaggg gtacacagca     1680

cctcaacagt tggaatatca cacacccgtg aacaagagcg ttgcgtatgg catggagagg     1740

gttaacagcc ctgctcgtgg catcgaatga atgagtttat tatgtacata gcaagtaagg     1800

aaaagaaatg gagaggctac agacagcaaa accatcttca gttaagtact caatgagcag     1860

aaaccagcat gcagtgacca cagaggccca aagtgggcat cggatctcct ggaactggag     1920

ttacagttgt gagccaccat gtggttgctg ggaatcaaag tcaggtcctc tgcaagagca     1980

gccagtgcta taaccaccga gccatctctg ccgatccttg gttagtgaat aagaagaaac     2040

catctgagga agcaagatgg cagtcagctg gagagcccat gggcaagccc ctaggaccta     2100

gctcccagcc tatcctctcc cctctaggca gggtttttaa gcacgtgtat gtagttggat     2160

gtgtgggtgt atgcgcgtgt gtttggctct ctgatgttag aggagcttgg gttattgagt     2220

ggttgtgagc tgtcctgtgg gtgctgggga ctgagcctgg gtattctact tagactcagt     2280

actgctgtga tgagtcacca taaccgaagc aggctgggtg gagggtgtgg attcaggctg     2340

cacctccata tcactggcat catagaagga actcaagcag ggcaggaacc tggaggcagg     2400

agctgatgca gaggcccatg agggtgctgc ttactggctt actcctcatg gcttgcttag     2460

gctgctctct tagagaaccc agagccacca gctcagagag ggctccacca acagtgggct     2520

aggctgatca ctaattaaga aaatgtcctg gaggctggtg gaaagtctga ttttatggag     2580

gtgttttctc aactaaggac tcctcctctc ctgtgactct agcttgagat gaaactgtcc     2640

aggacgagca gcacctgttc cccgaacctc tctccagcag tctgtagtta gctcctggag     2700

tggcttatgc ctgcagttgt cgttgctgcc cattaccagg ctgggccatc cctccctcca     2760

agaccatgga gagagtgcct tgagatccca cttccagaac cagtttccca gtgagctcaa     2820

ggagagtgtg acagtgacga tttctattac aaggagagcg gcactgacac cacccaagtc     2880

tagagggacc tcaaggatgc tactcagtga gagacagaga cacaagtcac gctgtgggat     2940

tccattacat gaagtatcca ggacaggagc cctgagatag aaagtggatg cgctgggcca     3000

gagagaggct tgagggaagg ctcagcatgg ggctgccttt tggactgatg gaatgttcta     3060

gatgcaaggt agtcatggct gcactgtgga cttcacacgg tgtgtgcttt aatgggaatg     3120

atccagggga tggacatttt ctactttatt ctgtgagagg ttttagggtt tggctgtgcc     3180

agagattaaa tggctataag agggcccagt agcaagtagg atggatggca gctctcttgt     3240

ggctgaggca ggaggatctg gagttcaagg tcattctcca ctttacagag agatcaagga     3300

cacaagactg tcgctaaaga aaaagcaagg tgtggacccc cttgagcagc gtttctcaga     3360

tgggctattt tcagactgca gaggctctgg gaacagcaga gccaggaatt agcaggtctg     3420

tggcgtcggc aggaaccact cagagctggc ccctggcctt ggcatgagtg cagttaggtc     3480

tcagggcttc accttgggga gaatacacac agcttgctgc agggtcccct tgtaattgac     3540

acaggtaggt cctggccatg agagcccccc ttgggaagcc aggaagggca gtgatgggcg     3600

cgtctctggg tgagggctgg cagcgagggc cgcaaatact ctgtgagaac tggctagttg     3660

ttttgtggat tttgttcttg tttttgattt ttatgtttta attttatgtg tatggttttt     3720

acttgcatta attatctgca ccagctgcat acctggtgcc tgtggagacc gaaaaaggac     3780

ttcaggtttt ctgtaactag ttacagatgg ctgggagcca ctgtgtgggt gcaggtaaca     3840

gaactctggt cctctgaaag agcagcctgt gctcttaggt acagggctgt ctctccagcc     3900

ctggctggtt tttggctttg gttttggttg attgtgttgg attgttggct tttgatagcc     3960

caggctggat ccctacactt tatgtagctg agactaaatc ctgggtgtcc tgagtgctag     4020

gtgctagggt gacagtcatt ccccattgcc catgtgcaaa ctacagacat tctctactgt     4080

gcatgcgcac accacggatc catgcaggac aattggaaac aggctgggtg gtggtcctgc     4140

gaccctgagg aagctgtcag tgagtgtgtt ggcaccaagg cactggacgg aggagggaag     4200

ggaggaggag atggcagata gcaagcaggg cctggggaat ctagagtgga gctagagccc     4260

cgtgctgtag ctgatccaca gttcccaact gaatttagac agggtcttaa ctgttgccac     4320

ttgttctcaa gatgtcttac aggtaaaaaa gtgactggat agtgccctcc accagcaggg     4380

cagtgtctgt ggctctagtg taggatacag agcctaggag ggaccatgtg tagccggcct     4440

tttgaagacc tgctaacacc tgtccttgct caccaagcct gtcctttctc cccagcaatg     4500

gcagatgagc ctggggacaa gtgaagacag ccagcacttt acctgtacca tctggaggtg     4560

agctgctgtg cacatgctgg gctagaggct cgttctctct ctccctctct ctctccctct     4620

ctctctccct ctccctctcc ctctccctct ctctctttct ccagctactt tgcatgcaca     4680

caccacagtc catgcaggac aagtaggctg ggcagtggtc ctgcgacccc aaggaagctc     4740

cagtatgtgt gctggcacca cagcactggg cagaggaggg aagagagagg aagatgtcag     4800

agagtaggca gggggctggg gaatctggtc acacaacagg aagtcaccaa aacactgctg     4860

attctattgt tcggttctgg ggaaacagaa gccaggatac caggagctca aggccagtcc     4920

tggccacaga gttagctggg ggccattctg agcttcctca gatcctgtct caaaaaccag     4980

tcttgaaaca aaaaaagaaa gtatacagca ggcaatagcc ctgaccccag agctgtcatc     5040

cgtcccttcc ccactccctg acctcagagc tgtcacccct accttcccca ctccctgacc     5100

ccagagctgt cacccgtccc tttcccactc cctgacccca gagctgtcac ccgtcccttc     5160

cccactccct gaccccagag ctgtcatccg tcccttcccc actccctgac cccagagctg     5220

tcatccgtcc cttccccact ccctgacccc agagctgtca tccgtccctt ccccactccc     5280

tgaccccaga gctgtcatcc gtcccttccc cactccctga ccccagagct gtcacccctc     5340

ccttccccac tccctgaccc cagagctgtc atccgtccct ttcccactcc ctgaccccag     5400

agctgtcatc cgtcccttcc ccaatccctg gcgcccacag aactacttct tacctctggc     5460

tttggcatcc tggagattta ccactatgga gtcccacatc accaggctct ttccggggcc     5520

tcagttgggt cctctccccc tcccccattc ctgtgctaac tctgtctttc cacaggcccc     5580

aggggaaatc ctacctctac ttcacacagt tcaaggctga gttgcgaggt gctgagatcg     5640

agtatgccat ggcctacgtg agtgtcagtc acggggaccc gaggacaaag ggacctgcaa     5700

ggccccagat accattcact gcaggggaca gggccccgtg tcactcagcc accctgttga     5760

cccctagggc tcccacccaa gttgagggga tcagcgggag gcccactatg tgggtggttc     5820

ctgcagagtg gctggaggag ccagggtggc ctcggtcagc tcctgtccct caggcagtca     5880

atgataggct cttcctcaca gtaccagtgc cctcagcagc ctcaccaagt gtgtttctgg     5940

gaaccaaggt gacagactga ggctgtccat cacctgtgat ctgacccact gcttgggctc     6000

tgctgggact actccctggg aataccacac ccgccctagc aagcatgcct gactttaggc     6060

cacagtgccc aggagacaaa actgagggga cccgagggga cttctctctc catgacgtgt     6120

gtctgctcaa gtgttctgtt ttattttagt ccaaagccgc atttgagaga gagagtgatg     6180

tccccctgaa aagtgaggag tttgaagtga ccaagacagc aggtaggtga aggtgggtcc     6240

cagcagtggg gggtacgcca ttacccagca agagccattt ggagagatct ctgtggagga     6300

gggtcctcgt gcctgtgcac tgcagatcag aaactgtctc gagaaagggc tgcaggctaa     6360

attcaagctg cttgtgggat ggactctgtg ttgaggttgt tccagccagt ttggttcaca     6420

gcatcctagt caccagtact ggtccacttt ctgttgctgt gacaacacac ctgaggcaag     6480

ctgctgcata aaacataaag gaccattcag tgcccaagtc tagaggttca agtgcaccag     6540

agcacctctg ctagactctg tgaggacctg gtgagggaga cactggcaga gccagggaag     6600

acagtccaca tccccccatg aacttactca aggcttcact ggggaattct aggcagacgc     6660

tccatgcctg caacgccccc agctccctca cagggggctg gggggagggg gatcctcaac     6720

aaggactcca ccctcaccat gcccactagc cctctttgta atttcccagt ctcctttgta     6780

gttccccatg cagggcagga tctccttgtg tcacactgcc cggctctgca gttttctatt     6840

ttcatccacc tcgcgccctg tcagacctgg cctctgtcgg acctctgtca gggtttaatt     6900

gtgcttgtgt cttgcagtgt ctcacaggcc tggggccttc aaagctgagc tctccaagct     6960

ggtgatcgta gccaaggcgg cacgctcgga gctgtgaccc tcgcctgtca agggccttca     7020

tgtccacgtt cctcaggcac actgaccggg actacttgtc tagggcactg gttcccatag     7080

gagctgccct gccctgcaca ggtcacactg tgtcactccg cagaactctc tgagcccggt     7140

cacctgtttt gccagggaag atgcagggca tgtgcggggg tgggatggaa ggacttcctg     7200

gctttcctga agtcaagatg tggtgtggtt tcccctctga gccacagatg agtgtcccca     7260

tcccaggacc actttctaac cccatccagg gcagctccac tcagaaggat gggaaaggat     7320

agaaaaaata aataaataag tagccacctt agtggtggct ctgtggggtc aggactcaga     7380


