                         SEQUENCE LISTING

<110>  ϺͨѧҽѧԺ
 
<120>  һάԼذе㼰Ӧ

<130>  P20406151CF

<150>  2020100767292
<151>  2020-01-23

<150>  2020112126398
<151>  2020-11-03

<160>  162   

<170>  PatentIn version 3.5

<210>  1
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LF2-VH

<400>  1

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Pro Met Asn Trp Val Arg Gln Ser His Val Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Glu Leu Leu Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Arg Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  2
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LF3-VH

<400>  2

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Pro Met Asn Trp Val Lys Gln Thr His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Asp Glu Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Arg Pro Phe Asp Phe Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  3
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LF7-VH

<400>  3

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Pro Met Asn Trp Val Arg Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Ser Tyr Asn Gly Gly Ala Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Ile Val His 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Arg Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  4
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LF15-VH

<400>  4

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Glu Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Phe Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Gly Gly Gly Asn Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  5
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LF16-VH

<400>  5

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Asp Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Gly Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Pro Thr Thr Gly Phe Val Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  6
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFm1-VH

<400>  6

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Glu Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Gly Ala Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Gln Leu Leu Gly Phe Ala Ser Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  7
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hLF101-104-VH

<400>  7

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Pro Met Asn Trp Val Arg Gln Ala Pro Gly Gln Asn Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Arg Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Arg Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  8
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hLF105-108-VH

<400>  8

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Pro Met Asn Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Arg Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  9
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hLF109-112-VH

<400>  9

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Pro Met Asn Trp Val Arg Gln Ala Pro Gly Gln Asn Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Arg Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  10
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hLF-113-116-VH

<400>  10

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Pro Met Asn Trp Val Arg Gln Ala Pro Gly Lys Asn Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Arg Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  11
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hLF-N55S-VH

<400>  11

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Pro Met Asn Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Tyr Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Arg Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  12
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hLF-N55D-VH

<400>  12

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Pro Met Asn Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Tyr Asp Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Arg Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  13
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hLF-N55Q-VH

<400>  13

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Pro Met Asn Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Tyr Gln Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Arg Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  14
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hLF-G56A-VH

<400>  14

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Pro Met Asn Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Tyr Asn Ala Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Arg Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  15
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hLF-G56V-VH

<400>  15

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Pro Met Asn Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Tyr Asn Val Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Arg Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  16
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LF2/LF3-VL

<400>  16

Asp Ile Gln Met Thr Gln Thr Ser Ser Ser Phe Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Asn Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Gln 
            100                 105     


<210>  17
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LF7-VL

<400>  17

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asp Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg 
            100                 105         


<210>  18
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LF11-VL

<400>  18

Asp Ile Val Ile Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Arg Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Phe Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  19
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LF15-VL

<400>  19

Asp Ile Gln Met Thr Gln Thr Ser Ser Tyr Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Thr Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Ile Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 
            100                 105     


<210>  20
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LF16-VL

<400>  20

Asp Ile Gln Met Thr Gln Thr Ser Ser Ser Phe Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  21
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFm1-VL

<400>  21

Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Asn Ile Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Thr Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Asp Arg Phe Thr Tyr Leu Asp Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Val Ser Tyr Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Tyr Cys Leu Gln Ser 
                85                  90                  95      


Ser Tyr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  22
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hLF101\105\109\113\N55-G56 MUTANT-VL

<400>  22

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Asn Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  23
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hLF102\106\110\114-VL

<400>  23

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Asn Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  24
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hLF103\107\111\115-VL

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Asn Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  25
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hLF104\108\112\116-VL

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Asn Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LF2/3/7/11 HCDR1

<400>  26

Gly Tyr Ser Phe Thr Gly Tyr Pro 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LF2/3/11/15/hLF101-116 HCDR2

<400>  27

Ile Asn Pro Tyr Asn Gly Gly Thr 
1               5               


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LF2/7/hLF101-116 HCDR3

<400>  28

Ala Arg Gly Gly Val Arg Pro Phe Ala Tyr 
1               5                   10  


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LF3/11 HCDR3

<400>  29

Ala Arg Gly Gly Val Arg Pro Phe Asp Phe 
1               5                   10  


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LF7 HCDR2

<400>  30

Ile Asn Ser Tyr Asn Gly Gly Ala 
1               5               


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LF15 HCDR1

<400>  31

Gly Tyr Ser Phe Thr Gly Tyr Thr 
1               5               


<210>  32
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LF15 HCDR3

<400>  32

Ser Arg Gly Gly Gly Asn Ser Trp Phe Ala Tyr 
1               5                   10      


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LF16 HCDR1

<400>  33

Gly Tyr Ala Phe Thr Gly Tyr Thr 
1               5               


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LF16 HCDR2

<400>  34

Ile Asn Gly Tyr Asn Gly Gly Thr 
1               5               


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LF16 HCDR3

<400>  35

Ala Arg Gly Gly Pro Thr Thr Gly Phe Val Tyr 
1               5                   10      


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFm1 HCDR1

<400>  36

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFm1 HCDR2

<400>  37

Ile Asn Pro Asn Asn Gly Gly Ala 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFm1 HCDR3

<400>  38

Gly Gln Leu Leu Gly Phe Ala Ser 
1               5               


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hLF101 HCDR1

<400>  39

Gly Tyr Thr Phe Thr Gly Tyr Pro 
1               5               


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hLF-N55S HCDR2

<400>  40

Ile Asn Pro Tyr Ser Gly Gly Thr 
1               5               


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hLF-N55D HCDR2

<400>  41

Ile Asn Pro Tyr Asp Gly Gly Thr 
1               5               


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hLF-N55Q HCDR2

<400>  42

Ile Asn Pro Tyr Gln Gly Gly Thr 
1               5               


<210>  43
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hLF-G56A HCDR2

<400>  43

Ile Asn Pro Tyr Asn Ala Gly Thr 
1               5               


<210>  44
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hLF-G56V HCDR2

<400>  44

Ile Asn Pro Tyr Asn Val Gly Thr 
1               5               


<210>  45
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LF2/3/16/hLF101-116 LCDR1

<400>  45

Glu Asp Ile Tyr Asn Arg 
1               5       


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LF2/3/16/hLF101-116 LCDR3

<400>  46

Gln Gln Tyr Trp Ser Thr Pro Thr 
1               5               


<210>  47
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LF7 LCDR1

<400>  47

Gln Asn Val Asp Thr Asn 
1               5       


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LF7 LCDR3

<400>  48

Gln Gln Tyr Asp Ser Tyr Pro Tyr Thr 
1               5                   


<210>  49
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LF11 LCDR1

<400>  49

Ser Ser Val Ser Tyr 
1               5   


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LF11 LCDR3

<400>  50

Gln Gln Trp Ser Ser Tyr Pro Pro Thr 
1               5                   


<210>  51
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LF15 LCDR1

<400>  51

Asp His Ile Asn Asn Trp 
1               5       


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LF15 LCDR3

<400>  52

Gln Gln Tyr Trp Ser Ile Pro Thr 
1               5               


<210>  53
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFm1 HCDR1

<400>  53

Gln Ser Leu Leu Asn Ser Asp Arg Phe Thr Tyr 
1               5                   10      


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFm1 LCDR3

<400>  54

Leu Gln Ser Ser Tyr Leu Pro Tyr Thr 
1               5                   


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Postn-F

<400>  55
ggggttgtca ctgtgaactg                                                   20


<210>  56
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Postn-R

<400>  56
cggctgctct aaatgatgaa                                                   20


<210>  57
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Col 4a1-F

<400>  57
ctggcacaaa agggacgag                                                    19


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Col 4a1-R

<400>  58
acgtggccga gaatttcacc                                                   20


<210>  59
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Col 5a3-F

<400>  59
ggcaaagatg gtattccagg acc                                               23


<210>  60
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Col 5a3-R

<400>  60
tgcttccttt gtgaccaggc atc                                               23


<210>  61
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse S100a4-F

<400>  61
agctcaagga gctactgacc ag                                                22


<210>  62
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse S100a4-R

<400>  62
gctgtccaag ttgctcatca cc                                                22


<210>  63
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Col 5a2-F

<400>  63
gtggcatagg agagaaaggt gc                                                22


<210>  64
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Col 5a2-R

<400>  64
gccaactaag cctctaggac ca                                                22


<210>  65
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Des-F

<400>  65
gtggatgcag ccactctagc                                                   20


<210>  66
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Des-R

<400>  66
ttagccgcga tggtctcata c                                                 21


<210>  67
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Acta2-F

<400>  67
tgctgacaga ggcaccactg aa                                                22


<210>  68
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Acta2-R

<400>  68
cagttgtacg tccagaggca tag                                               23


<210>  69
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Col 1a2-F

<400>  69
ttctgtgggt cctgctggga aa                                                22


<210>  70
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Col 1a2-R

<400>  70
ttgtcacctc ggatgccttg ag                                                22


<210>  71
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Col 7a1-F

<400>  71
caggcattgg tgccagtgaa ca                                                22


<210>  72
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Col 7a1-R

<400>  72
tggacctcca tcctcacagt ca                                                22


<210>  73
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Loxl2-F

<400>  73
attaacccca actatgaagt gcc                                               23


<210>  74
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Loxl2-R

<400>  74
ctgtctcctc actgaaggct c                                                 21


<210>  75
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse FN1-F

<400>  75
ccaggtcgaa aagggtatat ggg                                               23


<210>  76
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse FN1-R

<400>  76
cggttatccc tacttctcca gg                                                22


<210>  77
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Col 24a1-F

<400>  77
ccaggtcgaa aagggtatat ggg                                               23


<210>  78
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Col 24a1-R

<400>  78
cggttatccc tacttctcca gg                                                22


<210>  79
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Col 28a1-F

<400>  79
gcctggtctt aaaggagaac ctg                                               23


<210>  80
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Col 28a1-R

<400>  80
agccatcacc tttgagtcct gg                                                22


<210>  81
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 18sRNA-F

<400>  81
ttgactcaac acgggaaacc                                                   20


<210>  82
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 18sRNA-R

<400>  82
agacaaatcg ctccaccaac                                                   20


<210>  83
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Timp1-F

<400>  83
ggagagtgtc tgcggatact tc                                                22


<210>  84
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Timp1-R

<400>  84
gcaggtagtg atgtgcaaga gtc                                               23


<210>  85
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Postn -F

<400>  85
cagcaaacca ccttcacgga tc                                                22


<210>  86
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Postn-R

<400>  86
ttaaggaggc gctgaaccat gc                                                22


<210>  87
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Col 4a1 -F

<400>  87
tgttgacggc ttacctggag ac                                                22


<210>  88
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Col 4a1-R

<400>  88
ggtagaccaa ctccaggctc tc                                                22


<210>  89
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Col 8a1-F

<400>  89
aggaagccgt acccaagaaa gg                                                22


<210>  90
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Col 8a1-R

<400>  90
ggtatcccat gacctggcaa ac                                                22


<210>  91
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Col 3a1-F

<400>  91
cccactatta ttttggcaca acag                                              24


<210>  92
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Col 3a1-R

<400>  92
aacggatcct gagtcacaga ca                                                22


<210>  93
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Col 1a1-F

<400>  93
tagggtctag acatgttcag ctttgt                                            26


<210>  94
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Col 1a1-R

<400>  94
gtgattggtg ggatgtcttc gt                                                22


<210>  95
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Col 5a2-F

<400>  95
taggaactga tggtactcct gg                                                22


<210>  96
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Col 5a2-R

<400>  96
ggcctatcgg accctgaata c                                                 21


<210>  97
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Col 5a3-F

<400>  97
gtggccgtca gcatagatgg                                                   20


<210>  98
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Col 5a3-R

<400>  98
tgaatgtctc cctcgaaagt ctt                                               23


<210>  99
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Col 7a1-F

<400>  99
ttacgccgct gacattgtgt t                                                 21


<210>  100
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Col 7a1-R

<400>  100
accagccctt cgagaaagc                                                    19


<210>  101
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Des-F

<400>  101
tccagtccta cacctgcgag at                                                22


<210>  102
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Des-R

<400>  102
cgcaatgttg tcctggtagc ca                                                22


<210>  103
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human FN1-F

<400>  103
gagctgcacc tgtcttggga ac                                                22


<210>  104
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human FN1-R

<400>  104
ggagcaaatg gcaccgagat a                                                 21


<210>  105
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human 18sRNA-F

<400>  105
gagcggtcgg cgtcccccaa cttc                                              24


<210>  106
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human 18sRNA-R

<400>  106
gcgcgtgcag ccccggacat ctaa                                              24


<210>  107
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pear1-F

<400>  107
gctactgtct gctccttcag ttccc                                             25


<210>  108
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pear1-KO-R

<400>  108
ctcctacata gttggcagtg tttgg                                             25


<210>  109
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pear1-WT-R

<400>  109
gagggaaggg ttgtgtcagg                                                   20


<210>  110
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPear1-WT-F

<400>  110
gcagtgggct gatttcttc                                                    19


<210>  111
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPear1-KI-LD-R

<400>  111
tgctacagtt gactccccat                                                   20


<210>  112
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPear1-KI-RD-F

<400>  112
ggcagtttgg agaaggttg                                                    19


<210>  113
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPear1-WT-R

<400>  113
ccaaccccag ctacagtta                                                    19


<210>  114
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR1

<400>  114

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser 
            20                  25  


<210>  115
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR1

<400>  115

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser 
            20                  25  


<210>  116
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR1

<400>  116

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  117
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR2

<400>  117

Met Asn Trp Val Lys Gln Ser His Gly Glu Asn Leu Glu Trp Ile Gly 
1               5                   10                  15      


Val 
    


<210>  118
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR2

<400>  118

Met Asn Trp Val Lys Gln Ser His Gly Glu Ser Leu Glu Trp Ile Gly 
1               5                   10                  15      


Asp 
    


<210>  119
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR2

<400>  119

Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Asp Trp Ile Gly 
1               5                   10                  15      


Val 
    


<210>  120
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR2

<400>  120

Met Asn Trp Val Lys Gln Thr His Gly Lys Asn Leu Glu Trp Ile Gly 
1               5                   10                  15      


Leu 
    


<210>  121
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR2

<400>  121

Met Asn Trp Val Arg Gln Ala Pro Gly Lys Asn Leu Glu Trp Met Gly 
1               5                   10                  15      


Val 
    


<210>  122
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR2

<400>  122

Met Asn Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Met Gly 
1               5                   10                  15      


Val 
    


<210>  123
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR2

<400>  123

Met Asn Trp Val Arg Gln Ala Pro Gly Gln Asn Leu Glu Trp Met Gly 
1               5                   10                  15      


Val 
    


<210>  124
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR2

<400>  124

Met Asn Trp Val Arg Gln Ser His Gly Lys Asn Leu Glu Trp Ile Gly 
1               5                   10                  15      


Val 
    


<210>  125
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR2

<400>  125

Met Asn Trp Val Arg Gln Ser His Val Lys Asn Leu Glu Trp Ile Gly 
1               5                   10                  15      


Val 
    


<210>  126
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR3

<400>  126

Ser Tyr Asn Gln Lys Phe Lys Gly Arg Val Thr Leu Thr Val Asp Lys 
1               5                   10                  15      


Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  127
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR3

<400>  127

Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys 
1               5                   10                  15      


Ser Phe Ser Thr Ala Tyr Met Glu Ile Leu Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Tyr Cys 
        35              


<210>  128
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR3

<400>  128

Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys 
1               5                   10                  15      


Ser Ser Asn Ile Val His Met Glu Leu Leu Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Tyr Cys 
        35              


<210>  129
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR3

<400>  129

Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Ile Glu Leu Leu Ser Leu Thr Ser Asp Asp 
            20                  25                  30          


Ser Ala Val Tyr Tyr Cys 
        35              


<210>  130
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR3

<400>  130

Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Asp Glu 
            20                  25                  30          


Ser Ala Val Tyr Tyr Cys 
        35              


<210>  131
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR3

<400>  131

Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Ile Tyr Tyr Cys 
        35              


<210>  132
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR3

<400>  132

Ser Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp Lys 
1               5                   10                  15      


Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  133
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR3

<400>  133

Ser Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp Thr 
1               5                   10                  15      


Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  134
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR3

<400>  134

Ser Tyr Asn Gln Lys Phe Lys Gly Arg Val Thr Leu Thr Arg Asp Lys 
1               5                   10                  15      


Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  135
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR3

<400>  135

Thr Tyr Asn Gln Lys Phe Glu Gly Lys Ala Thr Leu Thr Val Asp Lys 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Tyr Cys 
        35              


<210>  136
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR4

<400>  136

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  137
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR4

<400>  137

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  138
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR1

<400>  138

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
            20                  25      


<210>  139
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR1

<400>  139

Asp Ile Gln Met Thr Gln Thr Ser Ser Ser Phe Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
            20                  25      


<210>  140
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR1

<400>  140

Asp Ile Gln Met Thr Gln Thr Ser Ser Tyr Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys Lys Ala Ser 
            20                  25      


<210>  141
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR1

<400>  141

Asp Ile Val Ile Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Arg 
            20                  25      


<210>  142
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR1

<400>  142

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser 
            20                  25      


<210>  143
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR1

<400>  143

Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Asn Ile Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Thr 
            20                  25      


<210>  144
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR2

<400>  144

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      


Ser 
    


<210>  145
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR2

<400>  145

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      


Ser 
    


<210>  146
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR2

<400>  146

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
1               5                   10                  15      


Ser 
    


<210>  147
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR2

<400>  147

Leu Asp Trp Tyr Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  148
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR2

<400>  148

Met Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  149
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR2

<400>  149

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  150
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR3

<400>  150

Lys Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala 
            20                  25                  30          


Thr Tyr Phe Cys 
        35      


<210>  151
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR3

<400>  151

Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr Glu Asp Val Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  152
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR3

<400>  152

Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Asn Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  153
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR3

<400>  153

Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Asn Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr Glu Asp Val Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  154
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR3

<400>  154

Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Asn Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  155
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR3

<400>  155

Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Tyr Ser Leu Thr Ile Thr Ser Leu Gln Thr Glu Asp Val Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  156
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR3

<400>  156

Tyr Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly 
            20                  25                  30          


Leu Tyr Tyr Cys 
        35      


<210>  157
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR3

<400>  157

Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala 
            20                  25                  30          


Glu Tyr Phe Cys 
        35      


<210>  158
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR4

<400>  158

Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
1               5                   10  


<210>  159
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR4

<400>  159

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  160
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR4

<400>  160

Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg 
1               5                   10  


<210>  161
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR4

<400>  161

Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 
1               5                   10  


<210>  162
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR4

<400>  162

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


