                         б

<110>  ϾƼ޹˾
 
<120>  ǶϿԭ弰;

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  738
<212>  DNA
<213>  ˹

<400>  1
caggtccaac tgcagcagcc tggggctgag ctggtgaggc ctggggcttc agtgaagctg     60

tcctgcaagg cttctggcta caccttcacc agctactgga taaactgggt gaagcagagg    120

cctggacaag gccttgagtg gatcggaaat atttatcctt ctgatagtta tactaactac    180

aatcaaaagt tcaaggacaa ggccacattg actgtagaca aatcctccag cacagcctac    240 

atgcagctca gcagcccgac atctgaggac tctgcggtct attactgtac aagatcgtgg    300

aggggtaact cctttgacta ctggggccaa ggcaccactc tcacagtctc ctcaggtgga    360

ggcggttcag gcggaggtgg ctctggcggt ggcggatcgg acattgtgat gacacagtct    420

ccatcctccc tgactgtgac agcaggagag aaggtcacta tgagctgcaa gtccagtcag    480

agtctgttaa acagtggaaa tcaaaagaac tacttgacct ggtaccagca gaaaccaggg    540

cagcctccta aactgttgat ctactgggca tccactaggg aatctggggt ccctgatcgc    600

ttcacaggca gtggatctgg aacagatttc actctcacca tcagcagtgt gcaggctgaa    660

gacctggcag tttattactg tcagaatgat tatagttatc cattcacgtt cggctcgggg    720

acaaagttgg aaataaaa                                                  738


<210>  2
<211>  246
<212>  PRT
<213>  ˹

<400>  2
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala
                5                   10                  15

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30

Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45

Gly Asn Ile Tyr Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60

Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80

Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95

Thr Arg Ser Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110

Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
        115                 120                 125

Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu
    130                 135                 140

Thr Val Thr Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln
145                 150                 155                 160

Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln
                165                 170                 175

Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr
            180                 185                 190

Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr
        195                 200                 205

Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val
    210                 215                 220

Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Phe Thr Phe Gly Ser Gly
225                 230                 235                 240

Thr Lys Leu Glu Ile Lys
                245


<210>  3
<211>  132
<212>  DNA
<213>  ˹

<400>  3
ggctccgagc tgacggacac tttgcaggcc gagaccgatc aacttgagga cgagaagagt    60

gcattgcaaa ccgaaatagc gaacttgctg aaggagaaag aaaagctcga atttatattg   120

gctgctcacc gc                                                       132


<210>  4
<211>  44
<212>  PRT
<213>  ˹

<400>  4
Gly Ser Glu Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln Leu Glu
                5                   10                  15

Asp Glu Lys Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu Lys Glu
            20                  25                  30

Lys Glu Lys Leu Glu Phe Ile Leu Ala Ala His Arg
        35                  40


<210>  5
<211>  126
<212>  DNA
<213>  ˹

<400>  5
gaaagaataa gtcgcctcga agaaaaggtg aaaacgctga aaagccaaaa cacagagttg     60

gcttcaaccg cctctctgtt gcgcgagcaa gtggcccaac tgaaacagaa ggtgttgtca    120

catgtc                                                               126


<210>  6
<211>  42
<212>  PRT
<213>  ˹

<400>  6
Glu Arg Ile Ser Arg Leu Glu Glu Lys Val Lys Thr Leu Lys Ser Gln
                5                   10                  15

Asn Thr Glu Leu Ala Ser Thr Ala Ser Leu Leu Arg Glu Gln Val Ala
            20                  25                  30

Gln Leu Lys Gln Lys Val Leu Ser His Val
        35                  40


<210>  7
<211>  366
<212>  DNA
<213>  ˹

<400>  7
caggtccaac ttgttgaatc aggcggtggc cttgtccagc cggggggttc cctcaggttg     60

agttgcgccg cttccggttc aattttctca ataaacgcta tgggttggta taggcaggcg    120

ccggggaagg gactggagct cgtagcagca attaccttcg gcggagggtc tacaaattat    180

gccgactcag tgaagggaag atttacgatt agcagagaca attcaaagaa tactctctac    240

ttgcaaatga atagccttag agccgaggac actgctgttt actattgtaa tgctgacttg    300

ctggttggtg gctttcctcg acgaaacgta tattggggcc agggcaccct cgtaacggtc    360

tccagc                                                               366


<210>  8
<211>  122
<212>  PRT
<213>  ˹

<400>  8
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
                5                   10                  15
 
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Asn
            20                  25                  30

Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45

Ala Ala Ile Thr Phe Gly Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val
    50                  55                  60

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95

Asn Ala Asp Leu Leu Val Gly Gly Phe Pro Arg Arg Asn Val Tyr Trp
            100                 105                 110

Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120


<210>  9
<211>  639
<212>  DNA
<213>  ˹

<400>  9
ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc     60

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag    120

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag    180

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg    240

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa    300

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc    360

cgggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc    420 

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg    480

cctcccgtgc tggactccga cggctccttc ttcctctata gcaagctcac cgtggacaag    540

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac    600

cactacacgc agaagagcct ctccctgtct ccgggtaaa                           639


<210>  10
<211>  232
<212>  PRT
<213>  ˹

<400>  10
Glu Pro Lys Ser Gln Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
                5                   10                  15

Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
            20                  25                  30

Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
        35                  40                  45

Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
    50                  55                  60
         
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
65                  70                  75                  80

Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
                85                  90                  95
 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
            100                 105                 110

Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
        115                 120                 125

Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
    130                 135                 140

Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
145                 150                 155                 160

Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
                165                 170                 175

Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
            180                 185                 190

Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
        195                 200                 205

Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
    210                 215                 220

Ser Leu Ser Leu Ser Pro Gly Lys
225                 230         


<210>  11
<211>  75
<212>  DNA
<213>  ˹

<400>  11
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc     60

accctttact gcaaa                                                      75


<210>  12
<211>  25
<212>  PRT
<213>  ˹

<400>  12
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
                5                   10                  15

Ser Leu Val Ile Thr Leu Tyr Cys Lys
            20                  25


<210>  13
<211>  120
<212>  DNA
<213>  ˹

<400>  13
cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     60

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     120


<210>  14
<211>  40
<212>  PRT
<213>  ˹

<400>  14
Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
                5                   10                  15

Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro
            20                  25                  30

Glu Glu Glu Glu Gly Gly Cys Glu
        35                  40


<210>  15
<211>  339
<212>  DNA
<213>  ˹

<400>  15
ctgagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag     60

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt    120

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac    180

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag    240

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac    300

acctacgacg cccttcacat gcaggccctg ccccctcgc                           339


<210>  16
<211>  113
<212>  PRT
<213>  ˹

<400>  16
Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
                5                   10                  15

Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu
            20                  25                  30

Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly
        35                  40                  45

Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60

Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu
65                  70                  75                  80

Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr
                85                  90                  95

Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro
            100                 105                 110
Arg


<210>  17
<211>  57
<212>  DNA
<213>  ˹

<400>  17
gagcccaaat ctcaggacaa aactcacaca tgcccaccgt gcccagcacc tgaactc        57       


<210>  18
<211>  19
<212>  PRT
<213>  ˹

<400>  18
Glu Pro Lys Ser Gln Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
                5                   10                  15
Pro Glu Leu


<210>  19
<211>  63
<212>  DNA
<213>  ˹

<400>  19
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg     60

ccg                                                                   63


<210>  20
<211>  21
<212>  PRT
<213>  ˹

<400>  20
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
                5                   10                  15

His Ala Ala Arg Pro
            20


<210>  21
<211>  66
<212>  DNA
<213>  ˹

<400>  21
atgctgctgc tcgtgacaag cctgctgctg tgcgagctgc cccaccctgc ctttctgctg     60 

atcccc                                                                66


<210>  22
<211>  22
<212>  PRT
<213>  ˹

<400>  22
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
                5                   10                  15

Ala Phe Leu Leu Ile Pro
            20


<210>  23
<211>  66
<212>  DNA
<213>  ˹

<400>  23
gtgaaacaga ctttgaattt tgaccttctc aagttggcgg gagacgtgga gtccaaccca     60

gggccg                                                                66


<210>  24
<211>  22
<212>  PRT
<213>  ˹

<400>  24
Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val
                5                   10                  15

Glu Ser Asn Pro Gly Pro
            20


<210>  25
<211>  135
<212>  DNA
<213>  ˹

<400>  25
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg     60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg    120

gacttcgcct gtgat                                                     135


<210>  26
<211>  45
<212>  PRT
<213>  ˹

<400>  26
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
                5                   10                  15

Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
            20                  25                  30

Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
        35                  40                  45


<210>  27
<211>  39
<212>  DNA
<213>  ˹

<400>  27
gaatcaaaat atggtcctcc ttgcccgcca tgtccggat                            45    


<210>  28
<211>  13
<212>  PRT
<213>  ˹

<400>  28
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Asp
                5                   10
