                         SEQUENCE LISTING

<110>  Ϻ꺺＼ɷ޹˾
       Ϻ꺺ҩ޹˾
        
<120>  LAG3¡弰ƱӦ

<130>  SH1903-20P450230

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  437
<212>  PRT
<213>  Artificial

<220>
<223>  LAG3-His 

<400>  1

Leu Gln Pro Gly Ala Glu Val Pro Val Val Trp Ala Gln Glu Gly Ala 
1               5                   10                  15      


Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile Pro Leu Gln Asp Leu Ser 
            20                  25                  30          


Leu Leu Arg Arg Ala Gly Val Thr Trp Gln His Gln Pro Asp Ser Gly 
        35                  40                  45              


Pro Pro Ala Ala Ala Pro Gly His Pro Leu Ala Pro Gly Pro His Pro 
    50                  55                  60                  


Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro Arg Arg Tyr Thr Val Leu 
65                  70                  75                  80  


Ser Val Gly Pro Gly Gly Leu Arg Ser Gly Arg Leu Pro Leu Gln Pro 
                85                  90                  95      


Arg Val Gln Leu Asp Glu Arg Gly Arg Gln Arg Gly Asp Phe Ser Leu 
            100                 105                 110         


Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala Gly Glu Tyr Arg Ala Ala 
        115                 120                 125             


Val His Leu Arg Asp Arg Ala Leu Ser Cys Arg Leu Arg Leu Arg Leu 
    130                 135                 140                 


Gly Gln Ala Ser Met Thr Ala Ser Pro Pro Gly Ser Leu Arg Ala Ser 
145                 150                 155                 160 


Asp Trp Val Ile Leu Asn Cys Ser Phe Ser Arg Pro Asp Arg Pro Ala 
                165                 170                 175     


Ser Val His Trp Phe Arg Asn Arg Gly Gln Gly Arg Val Pro Val Arg 
            180                 185                 190         


Glu Ser Pro His His His Leu Ala Glu Ser Phe Leu Phe Leu Pro Gln 
        195                 200                 205             


Val Ser Pro Met Asp Ser Gly Pro Trp Gly Cys Ile Leu Thr Tyr Arg 
    210                 215                 220                 


Asp Gly Phe Asn Val Ser Ile Met Tyr Asn Leu Thr Val Leu Gly Leu 
225                 230                 235                 240 


Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala Gly Ala Gly Ser Arg Val 
                245                 250                 255     


Gly Leu Pro Cys Arg Leu Pro Ala Gly Val Gly Thr Arg Ser Phe Leu 
            260                 265                 270         


Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly Pro Asp Leu Leu Val Thr 
        275                 280                 285             


Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu Glu Asp Val Ser Gln Ala 
    290                 295                 300                 


Gln Ala Gly Thr Tyr Thr Cys His Ile His Leu Gln Glu Gln Gln Leu 
305                 310                 315                 320 


Asn Ala Thr Val Thr Leu Ala Ile Ile Thr Val Thr Pro Lys Ser Phe 
                325                 330                 335     


Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu Cys Glu Val Thr Pro Val 
            340                 345                 350         


Ser Gly Gln Glu Arg Phe Val Trp Ser Ser Leu Asp Thr Pro Ser Gln 
        355                 360                 365             


Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala Gln Glu Ala Gln Leu Leu 
    370                 375                 380                 


Ser Gln Pro Trp Gln Cys Gln Leu Tyr Gln Gly Glu Arg Leu Leu Gly 
385                 390                 395                 400 


Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser Pro Gly Ala Gln Arg Ser 
                405                 410                 415     


Gly Arg Ala Pro Gly Ala Leu Pro Ala Gly His Leu Gly Ser Gly His 
            420                 425                 430         


His His His His His 
        435         


<210>  2
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  ɱ

<400>  2

Glu Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Phe Trp Val Arg Gln Thr Pro Glu Glu Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Asn Asp Gly Gly Asp Tyr Thr Asn Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Lys Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Gly Ile Tyr Tyr Asp Tyr Ala Ser Phe Gly Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  3
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  ɱ

<400>  3
gaggtgcagg tggtggagtc tgggggaggt ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cgtctggatt cactttcagt gactattaca tgttttgggt tcgccagact      120

ccggaagaga ggctggagtg ggtcgcaacc attaatgatg gtggtgatta caccaactat      180

ccagacagtg tgaaggggcg attcaccatc tccagagaca atgacaagaa caaactgtac      240

ctgcaaatga acagtctgaa gtctgaggac acagccatgt attactgtgc aagagagagt      300

gggatctact atgattacgc ttcgtttggt tactggggcc aggggactct ggtcactgtc      360

tct                                                                    363


<210>  4
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  ɱ

<400>  4

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Asn Leu 
        115 


<210>  5
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  ɱ

<400>  5
gatattgtga tgacccaggc tgcattctcc aatccagtca ctcttggaac atcagcttcc       60

atctcctgca ggtctagtaa gagtctctta tatagtaatg gcatcactta tttgtattgg      120

tatctgcaga agccaggcca gtctcctcag ctcctgattt atcagatgtc caaccttgcc      180

tcaggagtcc cagacaggtt cagtagcagt gggtcaggaa ctgatttcac actgagaatc      240

agcagagtgg aggctgagga tgtgggtgtt tattactgtg ctcaaaatct agaacttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaacgta atctg                      345


<210>  6
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  ɱ

<400>  6

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Phe Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Asn Asp Gly Gly Asp Tyr Thr Asn Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Gly Ile Tyr Tyr Asp Tyr Ala Ser Phe Gly Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  7
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  ɱ

<400>  7
caggtgcagc tggtggagag cggaggagga ctggtgaagc caggaggatc tctgaggctg       60

tcctgcgccg ctagcggctt caccttttct gactactata tgttctggat cagacaggct      120

ccaggcaagg gactggagtg ggtggctacc atcaacgacg gcggcgatta cacaaattat      180

cctgactccg tgaagggcag gtttaccatc tctcgggata acgccaagaa ttccctgtac      240

ctgcagatga acagcctgag agccgaggac acagccgtgt actattgtgc ccgcgagtct      300

ggcatctact atgattacgc ttccttcggc tattggggcc agggcaccct ggtgacagtg      360

tcctcc                                                                 366


<210>  8
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  ɱ

<400>  8

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Asn Leu 
        115 


<210>  9
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  ɱ

<400>  9
gacatcgtga tgacccagtc cccactgtct ctgtccgtga caccaggaga gcctgctagc       60

atctcttgca gatccagcaa gtccctgctg tatagcaacg gcatcaccta cctgtattgg      120

tacctgcaga agccaggcca gagcccccag ctgctgatct accagatgtc taatctggct      180

tccggagtgc ctgacaggtt ctccggaagc ggatctggaa ccgacttcac cctgaagatc      240

tctcgggtgg aggccgagga tgtgggcgtg tactattgtg ctcagaacct ggagctgcca      300

tggaccttcg gcggaggaac aaagctggag atcaagcgca atctg                      345


<210>  10
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  ɱ

<400>  10

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Arg Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Phe Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Asn Asp Gly Gly Asp Tyr Thr Asn Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Gly Ile Tyr Tyr Asp Trp Ala Ser Phe Gly Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  11
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  ɱ

<400>  11
caggtgcagc tggtggagag cggaggagga ctggtgaagc caggaggatc tctgaggctg       60

tcctgcgccg ctagcggctt ccggttttct gactactata tgttctggat cagacaggct      120

ccaggcaagg gactggagtg ggtggctacc atcaacgacg gcggcgatta cacaaattat      180

cctgactccg tgaagggcag gtttaccatc tctcgggata acgccaagaa ttccctgtac      240

ctgcagatga acagcctgag agccgaggac acagccgtgt actattgtgc ccgcgagtct      300

ggcatctact atgattgggc ttccttcggc tattggggcc agggcaccct ggtgacagtg      360

tcctcc                                                                 366


<210>  12
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  ɱ

<400>  12

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Lys Tyr Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Asn Leu 
        115 


<210>  13
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  ɱ

<400>  13
gacatcgtga tgacccagtc cccactgtct ctgtccgtga caccaggaga gcctgctagc       60

atctcttgca gatccagcaa gtccctgaag tatagcaacg gcatcaccta cctgtattgg      120

tacctgcaga agccaggcca gagcccccag ctgctgatct accagatgtc taatctggct      180

tccggagtgc ctgacaggtt ctccggaagc ggatctggaa ccgacttcac cctgaagatc      240

tctcgggtgg aggccgagga tgtgggcgtg tactattgtg cgcagaacct ggagctgcca      300

tggaccttcg gcggaggaac aaagctggag atcaagcgca atctg                      345


<210>  14
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  㶨

<400>  14

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  15
<211>  981
<212>  DNA
<213>  Artificial

<220>
<223>  㶨

<400>  15
gccagcacaa agggcccatc ggtcttcccg ctagcaccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      300

aaatatggtc ccccatgccc accatgccca gcacctgagt tcctgggggg accatcagtc      360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa      660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      840

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg      900

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc      960

ctctccctgt ctctgggtaa a                                                981


<210>  16
<211>  104
<212>  PRT
<213>  Artificial

<220>
<223>  㶨

<400>  16

Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
1               5                   10                  15      


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
            20                  25                  30          


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
        35                  40                  45              


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
65                  70                  75                  80  


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
                85                  90                  95      


Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 


<210>  17
<211>  312
<212>  DNA
<213>  Artificial

<220>
<223>  㶨

<400>  17
gctgcaccat ctgtcttcat cttcccgcca tctgatgagc agttgaaatc tggaactgcc       60

tctgttgtgt gcctgctgaa taacttctat cccagagagg ccaaagtaca gtggaaggtg      120

gataacgccc tccaatcggg taactcccag gagagtgtca cagagcagga cagcaaggac      180

agcacctaca gcctcagcag caccctgacg ctgagcaaag cagactacga gaaacacaaa      240

gtctacgcct gcgaagtcac ccatcagggc ctgagctcgc ccgtcacaaa gagcttcaac      300

aggggagagt gt                                                          312


<210>  18
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  HCDR1

<400>  18

Asp Tyr Tyr Met Phe 
1               5   


<210>  19
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  HCDR2

<400>  19

Thr Ile Asn Asp Gly Gly Asp Tyr Thr Asn Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  20
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  HCDR3

<400>  20

Glu Ser Gly Ile Tyr Tyr Asp Tyr Ala Ser Phe Gly Tyr 
1               5                   10              


<210>  21
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  HCDR3

<400>  21

Glu Ser Gly Ile Tyr Tyr Asp Trp Ala Ser Phe Gly Tyr 
1               5                   10              


<210>  22
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  LCDR1

<400>  22

Arg Ser Ser Lys Ser Leu Leu Tyr Ser Asn Gly Ile Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  23
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  LCDR1

<400>  23

Arg Ser Ser Lys Ser Leu Lys Tyr Ser Asn Gly Ile Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  24
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  LCDR2

<400>  24

Gln Met Ser Asn Leu Ala Ser 
1               5           


<210>  25
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LCDR3

<400>  25

Ala Gln Asn Leu Glu Leu Pro Trp Thr 
1               5                   


