                         SEQUENCE LISTING

<110>  The Regents of the University of California
 
<120>  Compositions and Methods for Altering Gamma Delta T Cell Activity

<130>  081906-1233908 (239110WO)

<150>  US 62/961,563
<151>  2020-01-15

<160>  414   

<170>  PatentIn version 3.5

<210>  1
<211>  697
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Arg Leu Val Ala Val Cys Arg Asp Gly Glu Glu Glu Phe Pro 
1               5                   10                  15      


Phe Glu Arg Arg Gln Ile Pro Leu Tyr Ile Asp Asp Thr Leu Thr Met 
            20                  25                  30          


Val Met Glu Phe Pro Asp Asn Val Leu Asn Leu Asp Gly His Gln Asn 
        35                  40                  45              


Asn Gly Ala Gln Leu Lys Gln Phe Ile Gln Arg His Gly Met Leu Lys 
    50                  55                  60                  


Gln Gln Asp Leu Ser Ile Ala Met Val Val Thr Ser Arg Glu Val Leu 
65                  70                  75                  80  


Ser Ala Leu Ser Gln Leu Val Pro Cys Val Gly Cys Arg Arg Ser Val 
                85                  90                  95      


Glu Arg Leu Phe Ser Gln Leu Val Glu Ser Gly Asn Pro Ala Leu Glu 
            100                 105                 110         


Pro Leu Thr Val Gly Pro Lys Gly Val Leu Ser Val Thr Arg Ser Cys 
        115                 120                 125             


Met Thr Asp Ala Lys Lys Leu Tyr Thr Leu Phe Tyr Val His Gly Ser 
    130                 135                 140                 


Lys Leu Asn Asp Met Ile Asp Ala Ile Pro Lys Ser Lys Lys Asn Lys 
145                 150                 155                 160 


Arg Cys Gln Leu His Ser Leu Asp Thr His Lys Pro Lys Pro Leu Gly 
                165                 170                 175     


Gly Cys Trp Met Asp Val Trp Glu Leu Met Ser Gln Glu Cys Arg Asp 
            180                 185                 190         


Glu Val Val Leu Ile Asp Ser Ser Cys Leu Leu Glu Thr Leu Glu Thr 
        195                 200                 205             


Tyr Leu Arg Lys His Arg Phe Cys Thr Asp Cys Lys Asn Lys Val Leu 
    210                 215                 220                 


Arg Ala Tyr Asn Ile Leu Ile Gly Glu Leu Asp Cys Ser Lys Glu Lys 
225                 230                 235                 240 


Gly Tyr Cys Ala Ala Leu Tyr Glu Gly Leu Arg Cys Cys Pro His Glu 
                245                 250                 255     


Arg His Ile His Val Cys Cys Glu Thr Asp Phe Ile Ala His Leu Leu 
            260                 265                 270         


Gly Arg Ala Glu Pro Glu Phe Ala Gly Gly Arg Arg Glu Arg His Ala 
        275                 280                 285             


Lys Thr Ile Asp Ile Ala Gln Glu Glu Val Leu Thr Cys Leu Gly Ile 
    290                 295                 300                 


His Leu Tyr Glu Arg Leu His Arg Ile Trp Gln Lys Leu Arg Ala Glu 
305                 310                 315                 320 


Glu Gln Thr Trp Gln Met Leu Phe Tyr Leu Gly Val Asp Ala Leu Arg 
                325                 330                 335     


Lys Ser Phe Glu Met Thr Val Glu Lys Val Gln Gly Ile Ser Arg Leu 
            340                 345                 350         


Glu Gln Leu Cys Glu Glu Phe Ser Glu Glu Glu Arg Val Arg Glu Leu 
        355                 360                 365             


Lys Gln Glu Lys Lys Arg Gln Lys Arg Lys Asn Arg Arg Lys Asn Lys 
    370                 375                 380                 


Cys Val Cys Asp Ile Pro Thr Pro Leu Gln Thr Ala Asp Glu Lys Glu 
385                 390                 395                 400 


Val Ser Gln Glu Lys Glu Thr Asp Phe Ile Glu Asn Ser Ser Cys Lys 
                405                 410                 415     


Ala Cys Gly Ser Thr Glu Asp Gly Asn Thr Cys Val Glu Val Ile Val 
            420                 425                 430         


Thr Asn Glu Asn Thr Ser Cys Thr Cys Pro Ser Ser Gly Asn Leu Leu 
        435                 440                 445             


Gly Ser Pro Lys Ile Lys Lys Gly Leu Ser Pro His Cys Asn Gly Ser 
    450                 455                 460                 


Asp Cys Gly Tyr Ser Ser Ser Met Glu Gly Ser Glu Thr Gly Ser Arg 
465                 470                 475                 480 


Glu Gly Ser Asp Val Ala Cys Thr Glu Gly Ile Cys Asn His Asp Glu 
                485                 490                 495     


His Gly Asp Asp Ser Cys Val His His Cys Glu Asp Lys Glu Asp Asp 
            500                 505                 510         


Gly Asp Ser Cys Val Glu Cys Trp Ala Asn Ser Glu Glu Asn Asp Thr 
        515                 520                 525             


Lys Gly Lys Asn Lys Lys Lys Lys Lys Lys Ser Lys Ile Leu Lys Cys 
    530                 535                 540                 


Asp Glu His Ile Gln Lys Leu Gly Ser Cys Ile Thr Asp Pro Gly Asn 
545                 550                 555                 560 


Arg Glu Thr Ser Gly Asn Thr Met His Thr Val Phe His Arg Asp Lys 
                565                 570                 575     


Thr Lys Asp Thr His Pro Glu Ser Cys Cys Ser Ser Glu Lys Gly Gly 
            580                 585                 590         


Gln Pro Leu Pro Trp Phe Glu His Arg Lys Asn Val Pro Gln Phe Ala 
        595                 600                 605             


Glu Pro Thr Glu Thr Leu Phe Gly Pro Asp Ser Gly Lys Gly Ala Lys 
    610                 615                 620                 


Ser Leu Val Glu Leu Leu Asp Glu Ser Glu Cys Thr Ser Asp Glu Glu 
625                 630                 635                 640 


Ile Phe Ile Ser Gln Asp Glu Ile Gln Ser Phe Met Ala Asn Asn Gln 
                645                 650                 655     


Ser Phe Tyr Ser Asn Arg Glu Gln Tyr Arg Gln His Leu Lys Glu Lys 
            660                 665                 670         


Phe Asn Lys Tyr Cys Arg Leu Asn Asp His Lys Arg Pro Ile Cys Ser 
        675                 680                 685             


Gly Trp Leu Thr Thr Ala Gly Ala Asn 
    690                 695         


<210>  2
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2

Xaa Asp Thr Lys Gly Lys Asn Lys Lys Lys Lys Lys Lys Ser Lys Ile 
1               5                   10                  15      


Leu Lys Cys Asp Glu His Ile Gln Lys Leu Gly Ser Cys Ile Thr Asp 
            20                  25                  30          


Pro Gly Asn Arg Glu Thr Ser Gly Asn Thr Met His Thr Val Phe His 
        35                  40                  45              


Arg Asp Lys Thr Lys Asp Thr His Pro Glu Ser Cys Cys Ser Ser Glu 
    50                  55                  60                  


Lys Gly Gly Gln Pro Leu Pro Trp Phe Glu His Arg Lys Asn Val Pro 
65                  70                  75                  80  


Gln Phe Ala Glu Pro Thr Glu Thr Leu Phe Gly Pro Asp Ser Gly Lys 
                85                  90                  95      


Gly Ala Lys Ser Leu Val Glu Leu Leu Val Ser Ile Pro Cys Gly Leu 
            100                 105                 110         


Thr Val His Asn Cys Leu Gly Thr Gly Trp Met Trp Glu Gly Ile Val 
        115                 120                 125             


Phe Glu Gly Leu Arg 
    130             


<210>  3
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Arg Leu Val Ala Val Cys Arg Asp Gly Glu Glu Glu Phe Pro 
1               5                   10                  15      


Phe Glu Arg Arg Gln Ile Pro Leu Tyr Ile Asp Asp Thr Leu Thr Met 
            20                  25                  30          


Val Met Glu Phe Pro Asp Asn Val Leu Asn Leu Asp Gly His Gln Asn 
        35                  40                  45              


Asn Gly Ala Gln Leu Lys Gln Phe Ile Gln Arg His Gly Met Leu Lys 
    50                  55                  60                  


Gln Gln Asp Leu Ser Ile Ala Met Val Val Thr Ser Arg Glu Val Leu 
65                  70                  75                  80  


Ser Ala Leu Ser Gln Leu Val Pro Cys Val Gly Cys Arg Arg Ser Val 
                85                  90                  95      


Glu Arg Leu Phe Ser Gln Leu Val Glu Ser Gly Asn Pro Ala Leu Glu 
            100                 105                 110         


Pro Leu Thr Val Gly Pro Lys Gly Val Leu Ser Val Thr Arg Ser Cys 
        115                 120                 125             


Met Thr Asp Ala Lys Lys Leu Tyr Thr Leu Phe Tyr Val His Gly Ser 
    130                 135                 140                 


Lys Leu Asn Asp Met Ile Asp Ala Ile Pro Lys Ser Lys Lys 
145                 150                 155             


<210>  4
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Arg Leu Val Ala Val Cys Arg Asp Gly Glu Glu Glu Phe Pro 
1               5                   10                  15      


Phe Glu Arg Arg Gln Ile Pro Leu Tyr Ile Asp Asp Thr Leu Thr Val 
            20                  25                  30          


Ser Gly Pro Gly Arg Ala Gly Pro Ala Ala Pro Leu Ala Ala Val Ser 
        35                  40                  45              


Pro Pro Pro Pro Pro Pro Gly Arg Ala Leu Arg Thr Gly Glu Arg Val 
    50                  55                  60                  


Cys Cys Asn Ser 
65              


<210>  5
<211>  1447
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala His Ser Lys Thr Arg Thr Asn Asp Gly Lys Ile Thr Tyr Pro 
1               5                   10                  15      


Pro Gly Val Lys Glu Ile Ser Asp Lys Ile Ser Lys Glu Glu Met Val 
            20                  25                  30          


Arg Arg Leu Lys Met Val Val Lys Thr Phe Met Asp Met Asp Gln Asp 
        35                  40                  45              


Ser Glu Glu Glu Lys Glu Leu Tyr Leu Asn Leu Ala Leu His Leu Ala 
    50                  55                  60                  


Ser Asp Phe Phe Leu Lys His Pro Asp Lys Asp Val Arg Leu Leu Val 
65                  70                  75                  80  


Ala Cys Cys Leu Ala Asp Ile Phe Arg Ile Tyr Ala Pro Glu Ala Pro 
                85                  90                  95      


Tyr Thr Ser Pro Asp Lys Leu Lys Asp Ile Phe Met Phe Ile Thr Arg 
            100                 105                 110         


Gln Leu Lys Gly Leu Glu Asp Thr Lys Ser Pro Gln Phe Asn Arg Tyr 
        115                 120                 125             


Phe Tyr Leu Leu Glu Asn Ile Ala Trp Val Lys Ser Tyr Asn Ile Cys 
    130                 135                 140                 


Phe Glu Leu Glu Asp Ser Asn Glu Ile Phe Thr Gln Leu Tyr Arg Thr 
145                 150                 155                 160 


Leu Phe Ser Val Ile Asn Asn Gly His Asn Gln Lys Val His Met His 
                165                 170                 175     


Met Val Asp Leu Met Ser Ser Ile Ile Cys Glu Gly Asp Thr Val Ser 
            180                 185                 190         


Gln Glu Leu Leu Asp Thr Val Leu Val Asn Leu Val Pro Ala His Lys 
        195                 200                 205             


Asn Leu Asn Lys Gln Ala Tyr Asp Leu Ala Lys Ala Leu Leu Lys Arg 
    210                 215                 220                 


Thr Ala Gln Ala Ile Glu Pro Tyr Ile Thr Asn Phe Phe Asn Gln Val 
225                 230                 235                 240 


Leu Met Leu Gly Lys Thr Ser Ile Ser Asp Leu Ser Glu His Val Phe 
                245                 250                 255     


Asp Leu Ile Leu Glu Leu Tyr Asn Ile Asp Ser His Leu Leu Leu Ser 
            260                 265                 270         


Val Leu Pro Gln Leu Glu Phe Lys Leu Lys Ser Asn Asp Asn Glu Glu 
        275                 280                 285             


Arg Leu Gln Val Val Lys Leu Leu Ala Lys Met Phe Gly Ala Lys Asp 
    290                 295                 300                 


Ser Glu Leu Ala Ser Gln Asn Lys Pro Leu Trp Gln Cys Tyr Leu Gly 
305                 310                 315                 320 


Arg Phe Asn Asp Ile His Val Pro Ile Arg Leu Glu Cys Val Lys Phe 
                325                 330                 335     


Ala Ser His Cys Leu Met Asn His Pro Asp Leu Ala Lys Asp Leu Thr 
            340                 345                 350         


Glu Tyr Leu Lys Val Arg Ser His Asp Pro Glu Glu Ala Ile Arg His 
        355                 360                 365             


Asp Val Ile Val Ser Ile Val Thr Ala Ala Lys Lys Asp Ile Leu Leu 
    370                 375                 380                 


Val Asn Asp His Leu Leu Asn Phe Val Arg Glu Arg Thr Leu Asp Lys 
385                 390                 395                 400 


Arg Trp Arg Val Arg Lys Glu Ala Met Met Gly Leu Ala Gln Ile Tyr 
                405                 410                 415     


Lys Lys Tyr Ala Leu Gln Ser Ala Ala Gly Lys Asp Ala Ala Lys Gln 
            420                 425                 430         


Ile Ala Trp Ile Lys Asp Lys Leu Leu His Ile Tyr Tyr Gln Asn Ser 
        435                 440                 445             


Ile Asp Asp Arg Leu Leu Val Glu Arg Ile Phe Ala Gln Tyr Met Val 
    450                 455                 460                 


Pro His Asn Leu Glu Thr Thr Glu Arg Met Lys Cys Leu Tyr Tyr Leu 
465                 470                 475                 480 


Tyr Ala Thr Leu Asp Leu Asn Ala Val Lys Ala Leu Asn Glu Met Trp 
                485                 490                 495     


Lys Cys Gln Asn Leu Leu Arg His Gln Val Lys Asp Leu Leu Asp Leu 
            500                 505                 510         


Ile Lys Gln Pro Lys Thr Asp Ala Ser Val Lys Ala Ile Phe Ser Lys 
        515                 520                 525             


Val Met Val Ile Thr Arg Asn Leu Pro Asp Pro Gly Lys Ala Gln Asp 
    530                 535                 540                 


Phe Met Lys Lys Phe Thr Gln Val Leu Glu Asp Asp Glu Lys Ile Arg 
545                 550                 555                 560 


Lys Gln Leu Glu Val Leu Val Ser Pro Thr Cys Ser Cys Lys Gln Ala 
                565                 570                 575     


Glu Gly Cys Val Arg Glu Ile Thr Lys Lys Leu Gly Asn Pro Lys Gln 
            580                 585                 590         


Pro Thr Asn Pro Phe Leu Glu Met Ile Lys Phe Leu Leu Glu Arg Ile 
        595                 600                 605             


Ala Pro Val His Ile Asp Thr Glu Ser Ile Ser Ala Leu Ile Lys Gln 
    610                 615                 620                 


Val Asn Lys Ser Ile Asp Gly Thr Ala Asp Asp Glu Asp Glu Gly Val 
625                 630                 635                 640 


Pro Thr Asp Gln Ala Ile Arg Ala Gly Leu Glu Leu Leu Lys Val Leu 
                645                 650                 655     


Ser Phe Thr His Pro Ile Ser Phe His Ser Ala Glu Thr Phe Glu Ser 
            660                 665                 670         


Leu Leu Ala Cys Leu Lys Met Asp Asp Glu Lys Val Ala Glu Ala Ala 
        675                 680                 685             


Leu Gln Ile Phe Lys Asn Thr Gly Ser Lys Ile Glu Glu Asp Phe Pro 
    690                 695                 700                 


His Ile Arg Ser Ala Leu Leu Pro Val Leu His His Lys Ser Lys Lys 
705                 710                 715                 720 


Gly Pro Pro Arg Gln Ala Lys Tyr Ala Ile His Cys Ile His Ala Ile 
                725                 730                 735     


Phe Ser Ser Lys Glu Thr Gln Phe Ala Gln Ile Phe Glu Pro Leu His 
            740                 745                 750         


Lys Ser Leu Asp Pro Ser Asn Leu Glu His Leu Ile Thr Pro Leu Val 
        755                 760                 765             


Thr Ile Gly His Ile Ala Leu Leu Ala Pro Asp Gln Phe Ala Ala Pro 
    770                 775                 780                 


Leu Lys Ser Leu Val Ala Thr Phe Ile Val Lys Asp Leu Leu Met Asn 
785                 790                 795                 800 


Asp Arg Leu Pro Gly Lys Lys Thr Thr Lys Leu Trp Val Pro Asp Glu 
                805                 810                 815     


Glu Val Ser Pro Glu Thr Met Val Lys Ile Gln Ala Ile Lys Met Met 
            820                 825                 830         


Val Arg Trp Leu Leu Gly Met Lys Asn Asn His Ser Lys Ser Gly Thr 
        835                 840                 845             


Ser Thr Leu Arg Leu Leu Thr Thr Ile Leu His Ser Asp Gly Asp Leu 
    850                 855                 860                 


Thr Glu Gln Gly Lys Ile Ser Lys Pro Asp Met Ser Arg Leu Arg Leu 
865                 870                 875                 880 


Ala Ala Gly Ser Ala Ile Val Lys Leu Ala Gln Glu Pro Cys Tyr His 
                885                 890                 895     


Glu Ile Ile Thr Leu Glu Gln Tyr Gln Leu Cys Ala Leu Ala Ile Asn 
            900                 905                 910         


Asp Glu Cys Tyr Gln Val Arg Gln Val Phe Ala Gln Lys Leu His Lys 
        915                 920                 925             


Gly Leu Ser Arg Leu Arg Leu Pro Leu Glu Tyr Met Ala Ile Cys Ala 
    930                 935                 940                 


Leu Cys Ala Lys Asp Pro Val Lys Glu Arg Arg Ala His Ala Arg Gln 
945                 950                 955                 960 


Cys Leu Val Lys Asn Ile Asn Val Arg Arg Glu Tyr Leu Lys Gln His 
                965                 970                 975     


Ala Ala Val Ser Glu Lys Leu Leu Ser Leu Leu Pro Glu Tyr Val Val 
            980                 985                 990         


Pro Tyr Thr Ile His Leu Leu Ala  His Asp Pro Asp Tyr  Val Lys Val 
        995                 1000                 1005             


Gln Asp  Ile Glu Gln Leu Lys  Asp Val Lys Glu Cys  Leu Trp Phe 
    1010                 1015                 1020             


Val Leu  Glu Ile Leu Met Ala  Lys Asn Glu Asn Asn  Ser His Ala 
    1025                 1030                 1035             


Phe Ile  Arg Lys Met Val Glu  Asn Ile Lys Gln Thr  Lys Asp Ala 
    1040                 1045                 1050             


Gln Gly  Pro Asp Asp Ala Lys  Met Asn Glu Lys Leu  Tyr Thr Val 
    1055                 1060                 1065             


Cys Asp  Val Ala Met Asn Ile  Ile Met Ser Lys Ser  Thr Thr Tyr 
    1070                 1075                 1080             


Ser Leu  Glu Ser Pro Lys Asp  Pro Val Leu Pro Ala  Arg Phe Phe 
    1085                 1090                 1095             


Thr Gln  Pro Asp Lys Asn Phe  Ser Asn Thr Lys Asn  Tyr Leu Pro 
    1100                 1105                 1110             


Pro Glu  Met Lys Ser Phe Phe  Thr Pro Gly Lys Pro  Lys Thr Thr 
    1115                 1120                 1125             


Asn Val  Leu Gly Ala Val Asn  Lys Pro Leu Ser Ser  Ala Gly Lys 
    1130                 1135                 1140             


Gln Ser  Gln Thr Lys Ser Ser  Arg Met Glu Thr Val  Ser Asn Ala 
    1145                 1150                 1155             


Ser Ser  Ser Ser Asn Pro Ser  Ser Pro Gly Arg Ile  Lys Gly Arg 
    1160                 1165                 1170             


Leu Asp  Ser Ser Glu Met Asp  His Ser Glu Asn Glu  Asp Tyr Thr 
    1175                 1180                 1185             


Met Ser  Ser Pro Leu Pro Gly  Lys Lys Ser Asp Lys  Arg Asp Asp 
    1190                 1195                 1200             


Ser Asp  Leu Val Arg Ser Glu  Leu Glu Lys Pro Arg  Gly Arg Lys 
    1205                 1210                 1215             


Lys Thr  Pro Val Thr Glu Gln  Glu Glu Lys Leu Gly  Met Asp Asp 
    1220                 1225                 1230             


Leu Thr  Lys Leu Val Gln Glu  Gln Lys Pro Lys Gly  Ser Gln Arg 
    1235                 1240                 1245             


Ser Arg  Lys Arg Gly His Thr  Ala Ser Glu Ser Asp  Glu Gln Gln 
    1250                 1255                 1260             


Trp Pro  Glu Glu Lys Arg Leu  Lys Glu Asp Ile Leu  Glu Asn Glu 
    1265                 1270                 1275             


Asp Glu  Gln Asn Ser Pro Pro  Lys Lys Gly Lys Arg  Gly Arg Pro 
    1280                 1285                 1290             


Pro Lys  Pro Leu Gly Gly Gly  Thr Pro Lys Glu Glu  Pro Thr Met 
    1295                 1300                 1305             


Lys Thr  Ser Lys Lys Gly Ser  Lys Lys Lys Ser Gly  Pro Pro Ala 
    1310                 1315                 1320             


Pro Glu  Glu Glu Glu Glu Glu  Glu Arg Gln Ser Gly  Asn Thr Glu 
    1325                 1330                 1335             


Gln Lys  Ser Lys Ser Lys Gln  His Arg Val Ser Arg  Arg Ala Gln 
    1340                 1345                 1350             


Gln Arg  Ala Glu Ser Pro Glu  Ser Ser Ala Ile Glu  Ser Thr Gln 
    1355                 1360                 1365             


Ser Thr  Pro Gln Lys Gly Arg  Gly Arg Pro Ser Lys  Thr Pro Ser 
    1370                 1375                 1380             


Pro Ser  Gln Pro Lys Lys Asn  Val Arg Val Gly Arg  Ser Lys Gln 
    1385                 1390                 1395             


Ala Ala  Thr Lys Glu Asn Asp  Ser Ser Glu Glu Val  Asp Val Phe 
    1400                 1405                 1410             


Gln Gly  Ser Ser Pro Val Asp  Asp Ile Pro Gln Glu  Glu Thr Glu 
    1415                 1420                 1425             


Glu Glu  Glu Val Ser Thr Val  Asn Val Arg Arg Arg  Ser Ala Lys 
    1430                 1435                 1440             


Arg Glu  Arg Arg 
    1445         


<210>  6
<211>  1391
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala His Ser Lys Thr Arg Thr Asn Asp Gly Lys Ile Thr Tyr Pro 
1               5                   10                  15      


Pro Gly Val Lys Glu Ile Ser Asp Lys Ile Ser Lys Glu Glu Met Val 
            20                  25                  30          


Arg Arg Leu Lys Met Val Val Lys Thr Phe Met Asp Met Asp Gln Asp 
        35                  40                  45              


Ser Glu Glu Glu Lys Glu Leu Tyr Leu Asn Leu Ala Leu His Leu Ala 
    50                  55                  60                  


Ser Asp Phe Phe Leu Lys His Pro Asp Lys Asp Val Arg Leu Leu Val 
65                  70                  75                  80  


Ala Cys Cys Leu Ala Asp Ile Phe Arg Ile Tyr Ala Pro Glu Ala Pro 
                85                  90                  95      


Tyr Thr Ser Pro Asp Lys Leu Lys Asp Ile Phe Met Phe Ile Thr Arg 
            100                 105                 110         


Gln Leu Lys Gly Leu Glu Asp Thr Lys Ser Pro Gln Phe Asn Arg Tyr 
        115                 120                 125             


Phe Tyr Leu Leu Glu Asn Ile Ala Trp Val Lys Ser Tyr Asn Ile Cys 
    130                 135                 140                 


Phe Glu Leu Glu Asp Ser Asn Glu Ile Phe Thr Gln Leu Tyr Arg Thr 
145                 150                 155                 160 


Leu Phe Ser Val Ile Asn Asn Gly His Asn Gln Lys Val His Met His 
                165                 170                 175     


Met Val Asp Leu Met Ser Ser Ile Ile Cys Glu Gly Asp Thr Val Ser 
            180                 185                 190         


Gln Glu Leu Leu Asp Thr Val Leu Val Asn Leu Val Pro Ala His Lys 
        195                 200                 205             


Asn Leu Asn Lys Gln Ala Tyr Asp Leu Ala Lys Ala Leu Leu Lys Arg 
    210                 215                 220                 


Thr Ala Gln Ala Ile Glu Pro Tyr Ile Thr Asn Phe Phe Asn Gln Val 
225                 230                 235                 240 


Leu Met Leu Gly Lys Thr Ser Ile Ser Asp Leu Ser Glu His Val Phe 
                245                 250                 255     


Asp Leu Ile Leu Glu Leu Tyr Asn Ile Asp Ser His Leu Leu Leu Ser 
            260                 265                 270         


Val Leu Pro Gln Leu Glu Phe Lys Leu Lys Ser Asn Asp Asn Glu Glu 
        275                 280                 285             


Arg Leu Gln Val Val Lys Leu Leu Ala Lys Met Phe Gly Ala Lys Asp 
    290                 295                 300                 


Ser Glu Leu Ala Ser Gln Asn Lys Pro Leu Trp Gln Cys Tyr Leu Gly 
305                 310                 315                 320 


Arg Phe Asn Asp Ile His Val Pro Ile Arg Leu Glu Cys Val Lys Phe 
                325                 330                 335     


Ala Ser His Cys Leu Met Asn His Pro Asp Leu Ala Lys Asp Leu Thr 
            340                 345                 350         


Glu Tyr Leu Lys Val Arg Ser His Asp Pro Glu Glu Ala Ile Arg His 
        355                 360                 365             


Asp Val Ile Val Ser Ile Val Thr Ala Ala Lys Lys Asp Ile Leu Leu 
    370                 375                 380                 


Val Asn Asp His Leu Leu Asn Phe Val Arg Glu Arg Thr Leu Asp Lys 
385                 390                 395                 400 


Arg Trp Arg Val Arg Lys Glu Ala Met Met Gly Leu Ala Gln Ile Tyr 
                405                 410                 415     


Lys Lys Tyr Ala Leu Gln Ser Ala Ala Gly Lys Asp Ala Ala Lys Gln 
            420                 425                 430         


Ile Ala Trp Ile Lys Asp Lys Leu Leu His Ile Tyr Tyr Gln Asn Ser 
        435                 440                 445             


Ile Asp Asp Arg Leu Leu Val Glu Arg Ile Phe Ala Gln Tyr Met Val 
    450                 455                 460                 


Pro His Asn Leu Glu Thr Thr Glu Arg Met Lys Cys Leu Tyr Tyr Leu 
465                 470                 475                 480 


Tyr Ala Thr Leu Asp Leu Asn Ala Val Lys Ala Leu Asn Glu Met Trp 
                485                 490                 495     


Lys Cys Gln Asn Leu Leu Arg His Gln Val Lys Asp Leu Leu Asp Leu 
            500                 505                 510         


Ile Lys Gln Pro Lys Thr Asp Ala Ser Val Lys Ala Ile Phe Ser Lys 
        515                 520                 525             


Val Met Val Ile Thr Arg Asn Leu Pro Asp Pro Gly Lys Ala Gln Asp 
    530                 535                 540                 


Phe Met Lys Lys Phe Thr Gln Val Leu Glu Asp Asp Glu Lys Ile Arg 
545                 550                 555                 560 


Lys Gln Leu Glu Val Leu Val Ser Pro Thr Cys Ser Cys Lys Gln Ala 
                565                 570                 575     


Glu Gly Cys Val Arg Glu Ile Thr Lys Lys Leu Gly Asn Pro Lys Gln 
            580                 585                 590         


Pro Thr Asn Pro Phe Leu Glu Met Ile Lys Phe Leu Leu Glu Arg Ile 
        595                 600                 605             


Ala Pro Val His Ile Asp Thr Glu Ser Ile Ser Ala Leu Ile Lys Gln 
    610                 615                 620                 


Val Asn Lys Ser Ile Asp Gly Thr Ala Asp Asp Glu Asp Glu Gly Val 
625                 630                 635                 640 


Pro Thr Asp Gln Ala Ile Arg Ala Gly Leu Glu Leu Leu Lys Val Leu 
                645                 650                 655     


Ser Phe Thr His Pro Ile Ser Phe His Ser Ala Glu Thr Phe Glu Ser 
            660                 665                 670         


Leu Leu Ala Cys Leu Lys Met Asp Asp Glu Lys Val Ala Glu Ala Ala 
        675                 680                 685             


Leu Gln Ile Phe Lys Asn Thr Gly Ser Lys Ile Glu Glu Asp Phe Pro 
    690                 695                 700                 


His Ile Arg Ser Ala Leu Leu Pro Val Leu His His Lys Ser Lys Lys 
705                 710                 715                 720 


Gly Pro Pro Arg Gln Ala Lys Tyr Ala Ile His Cys Ile His Ala Ile 
                725                 730                 735     


Phe Ser Ser Lys Glu Thr Gln Phe Ala Gln Ile Phe Glu Pro Leu His 
            740                 745                 750         


Lys Ser Leu Asp Pro Ser Asn Leu Glu His Leu Ile Thr Pro Leu Val 
        755                 760                 765             


Thr Ile Gly His Ile Ala Leu Leu Ala Pro Asp Gln Phe Ala Ala Pro 
    770                 775                 780                 


Leu Lys Ser Leu Val Ala Thr Phe Ile Val Lys Asp Leu Leu Met Asn 
785                 790                 795                 800 


Asp Arg Leu Pro Gly Lys Lys Thr Thr Lys Leu Trp Val Pro Asp Glu 
                805                 810                 815     


Glu Val Ser Pro Glu Thr Met Val Lys Ile Gln Ala Ile Lys Met Met 
            820                 825                 830         


Val Arg Trp Leu Leu Gly Met Lys Asn Asn His Ser Lys Ser Gly Thr 
        835                 840                 845             


Ser Thr Leu Arg Leu Leu Thr Thr Ile Leu His Ser Asp Gly Asp Leu 
    850                 855                 860                 


Thr Glu Gln Gly Lys Ile Ser Lys Pro Asp Met Ser Arg Leu Arg Leu 
865                 870                 875                 880 


Ala Ala Gly Ser Ala Ile Val Lys Leu Ala Gln Glu Pro Cys Tyr His 
                885                 890                 895     


Glu Ile Ile Thr Leu Glu Gln Tyr Gln Leu Cys Ala Leu Ala Ile Asn 
            900                 905                 910         


Asp Glu Cys Tyr Gln Val Arg Gln Val Phe Ala Gln Lys Leu His Lys 
        915                 920                 925             


Gly Leu Ser Arg Leu Arg Leu Pro Leu Glu Tyr Met Ala Ile Cys Ala 
    930                 935                 940                 


Leu Cys Ala Lys Asp Pro Val Lys Glu Arg Arg Ala His Ala Arg Gln 
945                 950                 955                 960 


Cys Leu Val Lys Asn Ile Asn Val Arg Arg Glu Tyr Leu Lys Gln His 
                965                 970                 975     


Ala Ala Val Ser Glu Lys Leu Leu Ser Leu Leu Pro Glu Tyr Val Val 
            980                 985                 990         


Pro Tyr Thr Ile His Leu Leu Ala  His Asp Pro Asp Tyr  Val Lys Val 
        995                 1000                 1005             


Gln Asp  Ile Glu Gln Leu Lys  Asp Val Lys Glu Cys  Leu Trp Phe 
    1010                 1015                 1020             


Val Leu  Glu Ile Leu Met Ala  Lys Asn Glu Asn Asn  Ser His Ala 
    1025                 1030                 1035             


Phe Ile  Arg Lys Met Val Glu  Asn Ile Lys Gln Thr  Lys Asp Ala 
    1040                 1045                 1050             


Gln Gly  Pro Asp Asp Ala Lys  Met Asn Glu Lys Leu  Tyr Thr Val 
    1055                 1060                 1065             


Cys Asp  Val Ala Met Asn Ile  Ile Met Ser Lys Ser  Thr Thr Tyr 
    1070                 1075                 1080             


Ser Leu  Glu Ser Pro Lys Asp  Pro Val Leu Pro Ala  Arg Phe Phe 
    1085                 1090                 1095             


Thr Gln  Pro Asp Lys Asn Phe  Ser Asn Thr Lys Asn  Tyr Leu Pro 
    1100                 1105                 1110             


Pro Glu  Met Lys Ser Phe Phe  Thr Pro Gly Lys Pro  Lys Thr Thr 
    1115                 1120                 1125             


Asn Val  Leu Gly Ala Val Asn  Lys Pro Leu Ser Ser  Ala Gly Lys 
    1130                 1135                 1140             


Gln Ser  Gln Thr Lys Ser Ser  Arg Met Glu Thr Val  Ser Asn Ala 
    1145                 1150                 1155             


Ser Ser  Ser Ser Asn Pro Ser  Ser Pro Gly Arg Ile  Lys Gly Arg 
    1160                 1165                 1170             


Leu Asp  Ser Ser Glu Met Asp  His Ser Glu Asn Glu  Asp Tyr Thr 
    1175                 1180                 1185             


Met Ser  Ser Pro Leu Pro Gly  Lys Lys Ser Asp Lys  Arg Asp Asp 
    1190                 1195                 1200             


Ser Asp  Leu Val Arg Ser Glu  Leu Glu Lys Pro Arg  Gly Arg Lys 
    1205                 1210                 1215             


Lys Thr  Pro Val Thr Glu Gln  Glu Glu Lys Leu Gly  Met Asp Asp 
    1220                 1225                 1230             


Leu Thr  Lys Leu Val Gln Glu  Gln Lys Pro Lys Gly  Ser Gln Arg 
    1235                 1240                 1245             


Ser Arg  Lys Arg Gly His Thr  Ala Ser Glu Ser Asp  Glu Gln Gln 
    1250                 1255                 1260             


Trp Pro  Glu Glu Lys Arg Leu  Lys Glu Asp Ile Leu  Glu Asn Glu 
    1265                 1270                 1275             


Asp Glu  Gln Asn Ser Pro Pro  Lys Lys Gly Lys Arg  Gly Arg Pro 
    1280                 1285                 1290             


Pro Lys  Pro Leu Gly Gly Gly  Thr Pro Lys Glu Glu  Pro Thr Met 
    1295                 1300                 1305             


Lys Thr  Ser Lys Lys Gly Ser  Lys Lys Lys Ser Gly  Pro Pro Ala 
    1310                 1315                 1320             


Pro Glu  Glu Glu Glu Glu Glu  Glu Arg Gln Ser Gly  Asn Thr Glu 
    1325                 1330                 1335             


Gln Lys  Ser Lys Ser Lys Gln  His Arg Val Ser Arg  Arg Ala Gln 
    1340                 1345                 1350             


Gln Arg  Ala Glu Ser Pro Glu  Ser Ser Ala Ile Glu  Ser Thr Gln 
    1355                 1360                 1365             


Ser Thr  Pro Gln Lys Gly Arg  Gly Arg Pro Ser Lys  Thr Pro Ser 
    1370                 1375                 1380             


Pro Ser  Gln Pro Lys Lys Asn  Val 
    1385                 1390     


<210>  7
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  7

Ile Lys Gln Thr Lys Asp Ala Gln Gly Pro Asp Asp Ala Lys Met Asn 
1               5                   10                  15      


Glu Lys Leu Tyr Thr Val Cys Asp Val Ala Met Asn Ile Ile Met Ser 
            20                  25                  30          


Lys Ser Thr Thr Tyr Ser Leu Glu Ser Pro Lys Asp Pro Val Leu Pro 
        35                  40                  45              


Ala Arg Phe Phe Thr Gln Pro Asp Lys Asn Phe Ser Asn Thr Lys Asn 
    50                  55                  60                  


Tyr Leu Pro Pro Glu Met Lys Ser Phe Phe Thr Pro Gly Lys Pro Lys 
65                  70                  75                  80  


Thr Thr Asn Val Leu Gly Ala Val Asn Lys Pro Leu Ser Ser Ala Gly 
                85                  90                  95      


Lys Gln Ser Gln Thr Lys Ser Ser Arg Met Glu Thr Val Ser Asn Ala 
            100                 105                 110         


Ser Ser Ser Ser Asn Pro Ser Ser Pro Gly Arg Ile Lys Gly Arg Leu 
        115                 120                 125             


Asp Ser Ser Glu Met Asp His Ser Glu Asn Glu Asp Tyr Thr Met Ser 
    130                 135                 140                 


Ser Pro Leu Pro Gly Lys Lys Ser Asp Lys Arg Asp Asp Ser Asp Leu 
145                 150                 155                 160 


Ser Glu Leu Glu Lys Pro Arg Gly Arg Lys Lys Thr Pro Val Thr Glu 
                165                 170                 175     


Gln Glu Glu Lys Leu Gly Met Asp Asp Leu Thr Lys Leu Val Gln Glu 
            180                 185                 190         


Gln Lys Pro Lys Gly Ser Gln Arg Ser Arg Lys Arg Gly His Thr Ala 
        195                 200                 205             


Ser Glu Ser Asp Glu Gln Gln Trp Pro Glu Glu Lys Arg Leu Lys Glu 
    210                 215                 220                 


Asp Ile Leu Glu Asn Glu Asp Glu Gln Asn Ser Pro Pro Lys Lys Gly 
225                 230                 235                 240 


Lys Arg Gly Arg Pro Pro Lys Pro Leu Gly Gly Gly Thr Pro Lys Glu 
                245                 250                 255     


Glu Pro Thr Met Lys Thr Ser Lys Lys Gly Ser Lys Lys Lys Ser Gly 
            260                 265                 270         


Pro Pro Ala Pro Glu Glu Glu Glu Glu Glu Glu Arg Gln Ser Gly Asn 
        275                 280                 285             


Thr Glu Gln Lys Ser Lys Ser Lys Gln His Arg Val Ser Arg 
    290                 295                 300         


<210>  8
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  8

Glu Gly Asp Thr Gly Gly Pro Ala Val Trp Lys Thr Arg Leu Arg Cys 
1               5                   10                  15      


Ala Leu Asn Lys Ser Ser Glu Phe Lys Glu Val Pro Glu Arg Gly Arg 
            20                  25                  30          


Met Asp Val Ala Glu Pro Tyr Lys Val Tyr Gln Leu Leu Pro Pro Gly 
        35                  40                  45              


Ile Val Ser Gly Gln Pro Gly Thr Gln Lys Val Pro Ser Lys Arg Gln 
    50                  55                  60                  


His Ser Ser Val Ser Ser Glu Arg Lys Glu Glu Glu Asp Ala Met Gln 
65                  70                  75                  80  


Asn Cys Thr Leu Ser Pro Ser Val Leu Gln Asp Ser Leu Asn Asn Glu 
                85                  90                  95      


Glu Glu Gly Ala Ser Gly Gly Ala Val His Ser Asp Ile Gly Ser Ser 
            100                 105                 110         


Ser Ser Ser Ser Ser Pro Glu Pro Gln Glu Val Thr Asp Thr Thr Glu 
        115                 120                 125             


Ala Pro Phe Gln Gly Asp Gln Arg Ser Leu Glu Phe Leu Leu Pro Pro 
    130                 135                 140                 


Glu Pro Asp Leu Val Arg Tyr Phe Gln Gly Leu Gly Pro Pro Pro Lys 
145                 150                 155                 160 


Phe Gln Val Thr Leu Asn Phe Trp Glu Glu Ser His Gly Ser Ser His 
                165                 170                 175     


Thr Pro Gln Asn Leu Ile Thr Val Lys Met Glu Gln Ala Phe Ala Arg 
            180                 185                 190         


Tyr Leu Leu Glu Gln Thr Pro Glu Gln Gln Ala Ala Ile Leu Ser Leu 
        195                 200                 205             


Val 
    


<210>  9
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Ser Gly Arg Ala Arg Cys Thr Arg Lys Leu Arg Asn Trp Val 
1               5                   10                  15      


Val Glu Gln Val Glu Ser Gly Gln Phe Pro Gly Val Cys Trp Asp Asp 
            20                  25                  30          


Thr Ala Lys Thr Met Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln 
        35                  40                  45              


Asp Phe Arg Glu Asp Gln Asp Ala Ala Phe Phe Lys Ala Trp Ala Ile 
    50                  55                  60                  


Phe Lys Gly Lys Tyr Lys Glu Gly Asp Thr Gly Gly Pro Ala Val Trp 
65                  70                  75                  80  


Lys Thr Arg Leu Arg Cys Ala Leu Asn Lys Ser Ser Glu Phe Lys Glu 
                85                  90                  95      


Val Pro Glu Arg Gly Arg Met Asp Val Ala Glu Pro Tyr Lys Val Tyr 
            100                 105                 110         


Gln Leu Leu Pro Pro Gly Ile Val Ser Gly Gln Pro Gly Thr Gln Lys 
        115                 120                 125             


Val Pro Ser Lys Arg Gln His Ser Ser Val Ser Ser Glu Arg Lys Glu 
    130                 135                 140                 


Glu Glu Asp Ala Met Gln Asn Cys Thr Leu Ser Pro Ser Val Leu Gln 
145                 150                 155                 160 


Asp Ser Leu Asn Asn Glu Glu Glu Gly Ala Ser Gly Gly Ala Val His 
                165                 170                 175     


Ser Asp Ile Gly Ser Ser Ser Ser Ser Ser Ser Pro Glu Pro Gln Glu 
            180                 185                 190         


Val Thr Asp Thr Thr Glu Ala Pro Phe Gln Gly Asp Gln Arg Ser Leu 
        195                 200                 205             


Glu Phe Leu Leu Pro Pro Glu Pro Asp Tyr Ser Leu Leu Leu Thr Phe 
    210                 215                 220                 


Ile Tyr Asn Gly Arg Val Val Gly Glu Ala Gln Val Gln Ser Leu Asp 
225                 230                 235                 240 


Cys Arg Leu Val Ala Glu Pro Ser Gly Ser Glu Ser Ser Met Glu Gln 
                245                 250                 255     


Val Leu Phe Pro Lys Pro Gly Pro Leu Glu Pro Thr Gln Arg Leu Leu 
            260                 265                 270         


Ser Gln Leu Glu Arg Gly Ile Leu Val Ala Ser Asn Pro Arg Gly Leu 
        275                 280                 285             


Phe Val Gln Arg Leu Cys Pro Ile Pro Ile Ser Trp Asn Ala Pro Gln 
    290                 295                 300                 


Ala Pro Pro Gly Pro Gly Pro His Leu Leu Pro Ser Asn Glu Cys Val 
305                 310                 315                 320 


Glu Leu Phe Arg Thr Ala Tyr Phe Cys Arg Asp Leu Val Arg Tyr Phe 
                325                 330                 335     


Gln Gly Leu Gly Pro Pro Pro Lys Phe Gln Val Thr Leu Asn Phe Trp 
            340                 345                 350         


Glu Glu Ser His Gly Ser Ser His Thr Pro Gln Asn Leu Ile Thr Val 
        355                 360                 365             


Lys Met Glu Gln Ala Phe Ala Arg Tyr Leu Leu Glu Gln Thr Pro Glu 
    370                 375                 380                 


Gln Gln Ala Ala Ile Leu Ser Leu Val 
385                 390             


<210>  10
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Ser Gly Arg Ala Arg Cys Thr Arg Lys Leu Arg Asn Trp Val 
1               5                   10                  15      


Val Glu Gln Val Glu Ser Gly Gln Phe Pro Gly Val Cys Trp Asp Asp 
            20                  25                  30          


Thr Ala Lys Thr Met Phe Arg Ile Pro Trp Lys His Ala Gly Leu Gly 
        35                  40                  45              


Asn Ile 
    50  


<210>  11
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Asp Val Ala Glu Pro Tyr Lys Val Tyr Gln Leu Leu Pro Pro Gly 
1               5                   10                  15      


Ile Val Ser Gly Gln Pro Gly Thr Gln Lys Val Pro Ser Lys Arg Gln 
            20                  25                  30          


His Ser Ser Val Ser Ser Glu Arg Lys Glu Glu Glu Asp Ala Met Gln 
        35                  40                  45              


Asn Cys Thr Leu Ser Pro Ser Val Leu Gln Asp Ser Leu Asn Asn Glu 
    50                  55                  60                  


Glu Glu Gly Ala Ser Gly Gly Ala Val His Ser Asp Ile Gly Ser Ser 
65                  70                  75                  80  


Ser Ser Ser Ser Ser Pro Glu Pro Gln Glu Val Thr Asp Thr Thr Glu 
                85                  90                  95      


Ala Pro Phe Gln Gly Asp Gln Arg Ser Leu Glu Phe Leu Leu Pro Pro 
            100                 105                 110         


Glu Pro Asp Tyr Ser Leu Leu Leu Thr Phe Ile Tyr Asn Gly Arg Val 
        115                 120                 125             


Val Gly Glu Ala Gln Val Gln Ser Leu Asp Cys Arg Leu Val Ala Glu 
    130                 135                 140                 


Pro Ser Gly Ser Glu Ser Ser Met Glu Gln Val Leu Phe Pro Lys Pro 
145                 150                 155                 160 


Gly Pro Leu Glu Pro Thr Gln Arg Leu Leu Ser Gln Leu Glu Arg Gly 
                165                 170                 175     


Ile Leu Val Ala Ser Asn Pro Arg Gly Leu Phe Val Gln Arg Leu Cys 
            180                 185                 190         


Pro Ile Pro Ile Ser Trp Asn Ala Pro Gln Ala Pro Pro Gly Pro Gly 
        195                 200                 205             


Pro His Leu Leu Pro Ser Asn Glu Cys Val Glu Leu Phe Arg Thr Ala 
    210                 215                 220                 


Tyr Phe Cys Arg Asp Pro Pro Cys Ser Leu Cys Met Ala Leu Leu Arg 
225                 230                 235                 240 


Leu Cys Val Ala Tyr Pro Val Trp Pro Tyr Ala Gln Pro Gly Ser Tyr 
                245                 250                 255     


Leu Ala Ala Leu Leu Gln Pro Arg Gln Trp Lys Arg Trp Phe Arg Leu 
            260                 265                 270         


Gly Gln Val Leu Ser Gly Pro Gly Pro Pro Thr Glu Val Pro Gly Asn 
        275                 280                 285             


Thr Glu Phe Leu Gly Arg Glu Pro Trp Leu Gln Pro Tyr Ser Thr Glu 
    290                 295                 300                 


Ser Tyr His Ser Glu Asp Gly Ala Gly Leu Cys Pro Ile Leu Ala Gly 
305                 310                 315                 320 


Ala Asp Ser Arg Ala Ala Gly Ser His Ser Val Pro Gly Val Glu Pro 
                325                 330                 335     


Gly Gly Pro Ile Phe His Leu Thr Ser Leu Phe Phe Leu Ser Pro Leu 
            340                 345                 350         


Lys 
    


<210>  12
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Ser Gly Arg Ala Arg Cys Thr Arg Lys Leu Arg Asn Trp Val 
1               5                   10                  15      


Val Glu Gln Val Glu Ser Gly Gln Phe Pro Gly Val Cys Trp Asp Asp 
            20                  25                  30          


Thr Ala Lys Thr Met Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln 
        35                  40                  45              


Asp Phe Arg Glu Asp Gln Asp Ala Ala Phe Phe Lys Ala Trp Ala Ile 
    50                  55                  60                  


Phe Lys Gly Lys Tyr Lys Glu Gly Asp Thr Gly Gly Pro Ala Val Trp 
65                  70                  75                  80  


Lys Thr Arg Leu Arg Cys Ala Leu Asn Lys Ser Ser Glu Phe Lys Glu 
                85                  90                  95      


Val Pro Glu Arg Gly Arg Met Asp Val Ala Glu Pro Tyr Lys Val Tyr 
            100                 105                 110         


Gln Leu Leu Pro Pro Gly Ile Val Ser Gly Gln Pro Gly Thr Gln Lys 
        115                 120                 125             


Val Pro Ser Lys Arg Gln His Ser Ser Val Ser Ser Glu Arg Lys Glu 
    130                 135                 140                 


Glu Glu Asp Ala Met Gln Asn Cys Thr Leu Ser Pro Ser Val Leu Gln 
145                 150                 155                 160 


Asp Ser Leu Asn Asn Glu Glu Glu Gly Ala Ser Gly Gly Ala Val His 
                165                 170                 175     


Ser Asp Ile Gly Ser Ser Ser Ser Ser Ser Ser Pro Glu Pro Gln Glu 
            180                 185                 190         


Val Thr Asp Thr Thr Glu Ala Pro Phe Gln Gly Asp Gln Arg Ser Leu 
        195                 200                 205             


Glu Phe Leu Leu Pro Pro Glu Pro Ala Pro Gly Arg Ala Val Leu Ser 
    210                 215                 220                 


Pro Asp Tyr Ser Leu Leu Leu Thr Phe Ile Tyr Asn Gly Arg Val Val 
225                 230                 235                 240 


Gly Glu Ala Gln Val Gln Ser Leu Asp Cys Arg Leu Val Ala Glu Pro 
                245                 250                 255     


Ser Gly Ser Glu Ser Ser Met Glu Gln Val Leu 
            260                 265         


<210>  13
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Ser Gly Arg Ala Arg Cys Thr Arg Lys Leu Arg Asn Trp Val 
1               5                   10                  15      


Val Glu Gln Val Glu Ser Gly Gln Phe Pro Gly Val Cys Trp Asp Asp 
            20                  25                  30          


Thr Ala Lys Thr Met Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln 
        35                  40                  45              


Asp Phe Arg Glu Asp Gln Asp Ala Ala Phe Phe Lys Ala Trp Ala Ile 
    50                  55                  60                  


Phe Lys Gly Lys Tyr Lys Glu Gly Asp Thr Gly Gly Pro Ala Val Trp 
65                  70                  75                  80  


Lys Thr Arg Leu Arg Cys Ala Leu Asn Lys Ser Ser Glu Phe Lys Glu 
                85                  90                  95      


Val Pro Glu Arg Gly Arg Met Asp Val Ala Glu Pro Tyr Lys Val Tyr 
            100                 105                 110         


Gln Leu Leu Pro Pro Gly Ile Val Ser Gly Gln Pro Gly Thr Gln Lys 
        115                 120                 125             


Val Pro Ser Lys Arg Gln His Ser Ser Val Ser Ser Glu Arg Lys Glu 
    130                 135                 140                 


Glu Glu Asp Ala Met Gln Asn Cys Thr Leu Ser Pro Ser Val Leu Gln 
145                 150                 155                 160 


Asp Ser Leu Asn Asn Leu Gln Thr Gln Leu Arg Pro Pro Phe Lys Gly 
                165                 170                 175     


Ile Arg Gly 
            


<210>  14
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Glu Ala Gln Gly Val Ala Glu Gly Ala Gly Pro Gly Ala Ala Ser 
1               5                   10                  15      


Gly Val Pro His Pro Ala Ala Leu Ala Pro Ala Ala Ala Pro Thr Leu 
            20                  25                  30          


Ala Pro Ala Ser Val Ala Ala Ala Ala Ser Gln Phe Thr Leu Leu Val 
        35                  40                  45              


Met Gln Pro Cys Ala Gly Gln Asp Glu Ala Ala Ala Pro Gly Gly Ser 
    50                  55                  60                  


Val Gly Ala Gly Lys Pro Val Arg Tyr Leu Cys Glu Gly Ala Gly Asp 
65                  70                  75                  80  


Gly Glu Glu Glu Ala Gly Glu Asp Glu Ala Asp Leu Leu Asp Thr Ser 
                85                  90                  95      


Asp Pro Pro Gly Gly Gly Glu Ser Ala Ala Ser Leu Glu Asp Leu Glu 
            100                 105                 110         


Asp Glu Glu Thr His Ser Gly Gly Glu Gly Ser Ser Gly Gly Ala Arg 
        115                 120                 125             


Arg Arg Gly Ser Gly Gly Gly Ser Met Ser Lys Thr Cys Thr Tyr Glu 
    130                 135                 140                 


Gly Cys Ser Glu Thr Thr Ser Gln Val Ala Lys Gln Arg Lys Pro Trp 
145                 150                 155                 160 


Met Cys Lys Lys His Arg Asn Lys Met Tyr Lys Asp Lys Tyr Lys Lys 
                165                 170                 175     


Lys Lys Ser Asp Gln Ala Leu Asn Cys Gly Gly Thr Ala Ser Thr Gly 
            180                 185                 190         


Ser Ala Gly Asn Val Lys Leu Glu Glu Ser Ala Asp Asn Ile Leu Ser 
        195                 200                 205             


Ile Val Lys Gln Arg Thr Gly Ser Phe Gly Asp Arg Pro Ala Arg Pro 
    210                 215                 220                 


Thr Leu Leu Glu Gln Val Leu Asn Gln Lys Arg Leu Ser Leu Leu Arg 
225                 230                 235                 240 


Ser Pro Glu Val Val Gln Phe Leu Gln Lys Gln Gln Gln Leu Leu Asn 
                245                 250                 255     


Gln Gln Val Leu Glu Gln Arg Gln Gln Gln Phe Pro Gly Thr Ser Met 
            260                 265                 270         


<210>  15
<211>  557
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val 
1               5                   10                  15      


Ala Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser 
            20                  25                  30          


Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg 
        35                  40                  45              


Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp 
    50                  55                  60                  


Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln 
65                  70                  75                  80  


Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val 
                85                  90                  95      


Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser 
            100                 105                 110         


Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile 
        115                 120                 125             


Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile 
    130                 135                 140                 


His Ile Ser Pro Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly 
145                 150                 155                 160 


Leu Ser Phe Thr Tyr Ser Leu Val Ile Trp Lys Asn Ser Ser Gly Val 
                165                 170                 175     


Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu 
            180                 185                 190         


Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr 
        195                 200                 205             


Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr 
    210                 215                 220                 


Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln 
225                 230                 235                 240 


Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr 
                245                 250                 255     


Phe Gln Val Gln Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn 
            260                 265                 270         


His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr 
        275                 280                 285             


Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu 
    290                 295                 300                 


Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu 
305                 310                 315                 320 


Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val 
                325                 330                 335     


Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala 
            340                 345                 350         


Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile 
        355                 360                 365             


Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile 
    370                 375                 380                 


Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr 
385                 390                 395                 400 


Val Tyr Cys Val Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn 
                405                 410                 415     


Lys Ser Ser Val Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly 
            420                 425                 430         


Asn Thr Ser Lys Ile Trp Leu Ile Val Gly Ile Cys Ile Ala Leu Phe 
        435                 440                 445             


Ala Leu Pro Phe Val Ile Tyr Ala Ala Lys Val Phe Leu Arg Cys Ile 
    450                 455                 460                 


Asn Tyr Val Phe Phe Pro Ser Leu Lys Pro Ser Ser Ser Ile Asp Glu 
465                 470                 475                 480 


Tyr Phe Ser Glu Gln Pro Leu Lys Asn Leu Leu Leu Ser Thr Ser Glu 
                485                 490                 495     


Glu Gln Ile Glu Lys Cys Phe Ile Ile Glu Asn Ile Ser Thr Ile Ala 
            500                 505                 510         


Thr Val Glu Glu Thr Asn Gln Thr Asp Glu Asp His Lys Lys Tyr Ser 
        515                 520                 525             


Ser Gln Thr Ser Gln Asp Ser Gly Asn Tyr Ser Asn Glu Asp Glu Ser 
    530                 535                 540                 


Glu Ser Lys Thr Ser Glu Glu Leu Gln Gln Asp Phe Val 
545                 550                 555         


<210>  16
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val 
1               5                   10                  15      


Ala Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser 
            20                  25                  30          


Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg 
        35                  40                  45              


Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp 
    50                  55                  60                  


Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln 
65                  70                  75                  80  


Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val 
                85                  90                  95      


Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser 
            100                 105                 110         


Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Val Glu Asn 
        115                 120                 125             


Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln Asn Gln Asn 
    130                 135                 140                 


Tyr Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr Phe Gln Val 
145                 150                 155                 160 


Gln Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn His Leu Tyr 
                165                 170                 175     


Lys Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr 
            180                 185                 


<210>  17
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val 
1               5                   10                  15      


Ala Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser 
            20                  25                  30          


Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg 
        35                  40                  45              


Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp 
    50                  55                  60                  


Tyr Gln Asn 
65          


<210>  18
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val 
1               5                   10                  15      


Ala Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser 
            20                  25                  30          


Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg 
        35                  40                  45              


Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp 
    50                  55                  60                  


Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln 
65                  70                  75                  80  


Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val 
                85                  90                  95      


Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser 
            100                 105                 110         


Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile 
        115                 120                 125             


Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile 
    130                 135                 140                 


His Ile Ser Pro Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly 
145                 150                 155                 160 


Leu Ser Phe Thr Tyr Ser Leu Val Ile Trp Lys Asn Ser Ser Gly Val 
                165                 170                 175     


Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu 
            180                 185                 190         


Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr 
        195                 200                 205             


Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr 
    210                 215                 220                 


Val Cys Ile Leu Gly Gly Arg Gly Arg Trp Ile Thr 
225                 230                 235     


<210>  19
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val 
1               5                   10                  15      


Ala Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser 
            20                  25                  30          


Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg 
        35                  40                  45              


Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp 
    50                  55                  60                  


Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln 
65                  70                  75                  80  


Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val 
                85                  90                  95      


Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser 
            100                 105                 110         


Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Gly Lys Asp 
        115                 120                 125             


<210>  20
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val 
1               5                   10                  15      


Ala Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser 
            20                  25                  30          


Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg 
        35                  40                  45              


Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp 
    50                  55                  60                  


Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln 
65                  70                  75                  80  


Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val 
                85                  90                  95      


Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser 
            100                 105                 110         


Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile 
        115                 120                 125             


Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile 
    130                 135                 140                 


His Ile Ser Pro Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly 
145                 150                 155                 160 


Leu Ser Phe Thr Tyr Ser Leu Val Ile Trp Lys Asn Ser Ser Gly Val 
                165                 170                 175     


Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu 
            180                 185                 190         


Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr 
        195                 200                 205             


Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr 
    210                 215                 220                 


Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln 
225                 230                 235                 240 


Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr 
                245                 250                 255     


Phe Gln Val Gln Trp Leu His Leu Tyr Phe Arg Arg Pro Arg 
            260                 265                 270 


<210>  21
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln Asn Ile Thr Ser Thr 
1               5                   10                  15      


Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val Tyr Glu Glu Ile Lys 
            20                  25                  30          


Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser Ser Trp Tyr Glu Val 
        35                  40                  45              


Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile Gly Pro Pro Glu Val 
    50                  55                  60                  


His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile His Ile Ser Pro Gly 
65                  70                  75                  80  


Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly Leu Ser Phe Thr Tyr 
                85                  90                  95      


Ser Leu Val Ile Trp Lys Asn Ser Ser Gly Val Glu Glu Arg Ile Glu 
            100                 105                 110         


Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu Ser Pro Glu Thr Thr 
        115                 120                 125             


Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr Ser Trp Lys Ile Gly 
    130                 135                 140                 


Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr Val Glu Asn Glu Leu 
145                 150                 155                 160 


Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln Asn Gln Asn Tyr Val 
                165                 170                 175     


Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr Phe Gln Val Gln Trp 
            180                 185                 190         


Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn His Leu Tyr Lys Trp 
        195                 200                 205             


Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr Thr Gln Cys Val Phe 
    210                 215                 220                 


Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu Leu Arg Val Gln Ala 
225                 230                 235                 240 


Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu Glu Ile Lys Phe Asp 
                245                 250                 255     


Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val Phe Asn Ile Arg Ser 
            260                 265                 270         


Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala Pro Lys Gln Ser Gly 
        275                 280                 285             


Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile Tyr Glu Ile Ile Phe 
    290                 295                 300                 


Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile Ile Glu Lys Lys Thr 
305                 310                 315                 320 


Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr Val Tyr Cys Val Lys 
                325                 330                 335     


Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn Lys Ser Ser Val Phe 
            340                 345                 350         


Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly Asn Thr Ser Lys Ile 
        355                 360                 365             


Trp Leu Ile Val Gly Ile Cys Ile Ala Leu Phe Ala Leu Pro Phe Val 
    370                 375                 380                 


Ile Tyr Ala Ala Lys Val Phe Leu Arg Cys Ile Asn Tyr Val Phe Phe 
385                 390                 395                 400 


Pro Ser Leu Lys Pro Ser Ser Ser Ile Asp Glu Tyr Phe Ser Glu Gln 
                405                 410                 415     


Pro Leu Lys Asn Leu Leu Leu Ser Thr Ser Glu Glu Gln Ile Glu Lys 
            420                 425                 430         


Cys Phe Ile Ile Glu Asn Ile Ser Thr Ile Ala Thr Val Glu Glu Thr 
        435                 440                 445             


Asn Gln Thr Asp Glu Asp His Lys Lys Tyr Ser Ser Gln Thr Ser Gln 
    450                 455                 460                 


Asp Ser Gly Asn Tyr Ser Asn Glu Asp Glu Ser Glu Ser Lys Thr Ser 
465                 470                 475                 480 


Glu Glu Leu Gln Gln Asp Phe Val 
                485             


<210>  22
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Val Thr Arg Ala Gly Ala Gly Thr Ala Val Ala Gly Ala Val Val 
1               5                   10                  15      


Val Ala Leu Leu Ser Ala Ala Leu Ala Leu Tyr Gly Pro Pro Leu Asp 
            20                  25                  30          


Ala Val Leu Glu Arg Ala Phe Ser Leu Arg Lys Ala His Ser Ile Lys 
        35                  40                  45              


Asp Met Glu Asn Thr Leu Gln Leu Val Arg Asn Ile Ile Pro Pro Leu 
    50                  55                  60                  


Ser Ser Thr Lys His Lys Gly Gln Asp Gly Arg Ile Gly Val Val Gly 
65                  70                  75                  80  


Gly Cys Gln Glu Tyr Thr Gly Ala Pro Tyr Phe Ala Ala Ile Ser Ala 
                85                  90                  95      


Leu Lys Val Gly Ala Asp Leu Ser His Val Phe Cys Ala Ser Ala Ala 
            100                 105                 110         


Ala Pro Val Ile Lys Ala Tyr Ser Pro Glu Leu Ile Val His Pro Val 
        115                 120                 125             


Leu Asp Ser Pro Asn Ala Val His Glu Val Glu Lys Trp Leu Pro Arg 
    130                 135                 140                 


Leu His Ala Leu Val Val Gly Pro Gly Leu Gly Arg Asp Asp Ala Leu 
145                 150                 155                 160 


Leu Arg Asn Val Gln Gly Ile Leu Glu Val Ser Lys Ala Arg Asp Ile 
                165                 170                 175     


Pro Val Val Ile Asp Ala Asp Gly Leu Trp Leu Val Ala Gln Gln Pro 
            180                 185                 190         


Ala Leu Ile His Gly Tyr Arg Lys Ala Val Leu Thr Pro Asn His Val 
        195                 200                 205             


Glu Phe Ser Arg Leu Tyr Asp Ala Val Leu Arg Gly Pro Met Asp Ser 
    210                 215                 220                 


Asp Asp Ser His Gly Ser Val Leu Arg Leu Ser Gln Ala Leu Gly Asn 
225                 230                 235                 240 


Val Thr Val Val Gln Lys Gly Glu Arg Asp Ile Leu Ser Asn Gly Gln 
                245                 250                 255     


Gln Val Leu Val Cys Ser Gln Glu Gly Ser Ser Arg Arg Cys Gly Gly 
            260                 265                 270         


Gln Gly Asp Leu Leu Ser Gly Ser Leu Gly Val Leu Val His Trp Ala 
        275                 280                 285             


Leu Leu Ala Gly Pro Gln Lys Thr Asn Gly Gly Ile Ser Asp Leu Lys 
    290                 295                 300                 


Leu Thr Ile Trp Gly Pro Glu Ile Glu Thr Gly Val Lys Thr Arg Ala 
305                 310                 315                 320 


Gln Gly Ser Cys Gly Pro Arg Thr Thr Thr Pro Thr Ser Pro His Leu 
                325                 330                 335     


Leu Leu Ser Pro Ser Pro Gln Val Gln Pro Ser Pro Gly Gly Arg Val 
            340                 345                 350         


Trp Arg Leu Leu Ser His Gln Ala Val Gln Pro Pro Ser Leu Pro Glu 
        355                 360                 365             


Ala Arg Ser Leu His His His Leu Arg His Asp Arg Arg Gly Gly Gly 
    370                 375                 380                 


Arg Leu Gln Gln Ala Leu 
385                 390 


<210>  23
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Leu Pro Asp Gly Pro Gly Ser Ser Leu Trp Gly Asn Pro Gly Leu 
1               5                   10                  15      


Gln Thr Ser Asp Ser Pro Asn Ala Val His Glu Val Glu Lys Trp Leu 
            20                  25                  30          


Pro Arg Leu His Ala Leu Val Val Gly Pro Gly Leu Gly Arg Asp Asp 
        35                  40                  45              


Ala Leu Leu Arg Asn Val Gln Gly Ile Leu Glu Val Ser Lys Ala Arg 
    50                  55                  60                  


Asp Ile Pro Val Val Ile Asp Ala Asp Gly Leu Trp Leu Val Ala Gln 
65                  70                  75                  80  


Gln Pro Ala Leu Ile His Gly Tyr Arg Lys Ala Val Leu Thr Pro Asn 
                85                  90                  95      


His Val Glu Phe Ser Arg Leu Tyr Asp Ala Val Leu Arg Gly Pro Met 
            100                 105                 110         


Asp Ser Asp Asp Ser His Gly Ser Val Leu Arg Leu Ser Gln Ala Leu 
        115                 120                 125             


Gly Asn Val Thr Val Val Gln Lys Gly Glu Arg Asp Ile Leu Ser Asn 
    130                 135                 140                 


Gly Gln Gln Val Leu Val Cys Ser Gln Glu Gly Ser Ser Arg Arg Cys 
145                 150                 155                 160 


Gly Gly Gln Gly Asp Leu Leu Ser Gly Ser Leu Gly Val Leu Val His 
                165                 170                 175     


Trp Ala Leu Leu Ala Gly Pro Gln Lys Thr Asn Gly Ser Ser Pro Leu 
            180                 185                 190         


Leu Val Ala Ala Phe Gly Ala Cys Ser Leu Thr Arg Gln Cys Asn His 
        195                 200                 205             


Gln Ala Phe Gln Lys His Gly Arg Ser Thr Thr Thr Ser Asp Met Ile 
    210                 215                 220                 


Ala Glu Val Gly Ala Ala Phe Ser Lys Leu Phe Glu Thr 
225                 230                 235         


<210>  24
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Thr Asp Val Asn 
1               5                   10                  15      


Thr His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg Gly 
        35                  40                  45              


Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Thr Asn Asn Glu Lys 
    50                  55                  60                  


Val Val Val Lys Ile Leu Lys Pro Val Lys Lys Lys Lys Ile Lys Arg 
65                  70                  75                  80  


Glu Ile Lys Ile Leu Glu Asn Leu Arg Gly Gly Pro Asn Ile Ile Thr 
                85                  90                  95      


Leu Ala Asp Ile Val Lys Asp Pro Val Ser Arg Thr Pro Ala Leu Val 
            100                 105                 110         


Phe Glu His Val Asn Asn Thr Asp Phe Lys Gln Leu Tyr Gln Thr Leu 
        115                 120                 125             


Thr Asp Tyr Asp Ile Arg Phe Tyr Met Tyr Glu Ile Leu Lys Ala Leu 
    130                 135                 140                 


Asp Tyr Cys His Ser Met Gly Ile Met His Arg Asp Val Lys Pro His 
145                 150                 155                 160 


Asn Val Met Ile Asp His Glu His Arg Lys Leu Arg Leu Ile Asp Trp 
                165                 170                 175     


Gly Leu Ala Glu Phe Tyr His Pro Gly Gln Glu Tyr Asn Val Arg Val 
            180                 185                 190         


Ala Ser Arg Tyr Phe Lys Gly Pro Glu Leu Leu Val Asp Tyr Gln Met 
        195                 200                 205             


Tyr Asp Tyr Ser Leu Asp Met Trp Ser Leu Gly Cys Met Leu Ala Ser 
    210                 215                 220                 


Met Ile Phe Arg Lys Glu Pro Phe Phe His Gly His Asp Asn Tyr Asp 
225                 230                 235                 240 


Gln Leu Val Arg Ile Ala Lys Val Leu Gly Thr Glu Asp Leu Tyr Asp 
                245                 250                 255     


Tyr Ile Asp Lys Tyr Asn Ile Glu Leu Asp Pro Arg Phe Asn Asp Ile 
            260                 265                 270         


Leu Gly Arg His Ser Arg Lys Arg Trp Glu Arg Phe Val His Ser Glu 
        275                 280                 285             


Asn Gln His Leu Val Ser Pro Glu Ala Leu Asp Phe Leu Asp Lys Leu 
    290                 295                 300                 


Leu Arg Tyr Asp His Gln Ser Arg Leu Thr Ala Arg Glu Ala Met Glu 
305                 310                 315                 320 


His Pro Tyr Phe Tyr Thr Val Val Lys Asp Gln Ala Arg Met Gly Ser 
                325                 330                 335     


Ser Ser Met Pro Gly Gly Ser Thr Pro Val Ser Ser Ala Asn Met Met 
            340                 345                 350         


Ser Gly Ile Ser Ser Val Pro Thr Pro Ser Pro Leu Gly Pro Leu Ala 
        355                 360                 365             


Gly Ser Pro Val Ile Ala Ala Ala Asn Pro Leu Gly Met Pro Val Pro 
    370                 375                 380                 


Ala Ala Ala Gly Ala Gln Gln 
385                 390     


<210>  25
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Tyr Glu Ile Leu Lys Ala Leu Asp Tyr Cys His Ser Met Gly Ile 
1               5                   10                  15      


Met His Arg Asp Val Lys Pro His Asn Val Met Ile Asp His Glu His 
            20                  25                  30          


Arg Lys Leu Arg Leu Ile Asp Trp Gly Leu Ala Glu Phe Tyr His Pro 
        35                  40                  45              


Gly Gln Glu Tyr Asn Val Arg Val Ala Ser Arg Tyr Phe Lys Gly Pro 
    50                  55                  60                  


Glu Leu Leu Val Asp Tyr Gln Met Tyr Asp Tyr Ser Leu Asp Met Trp 
65                  70                  75                  80  


Ser Leu Gly Cys Met Leu Ala Ser Met Ile Phe Arg Lys Glu Pro Phe 
                85                  90                  95      


Phe His Gly His Asp Asn Tyr Asp Gln Leu Val Arg Ile Ala Lys Val 
            100                 105                 110         


Leu Gly Thr Glu Asp Leu Tyr Asp Tyr Ile Asp Lys Tyr Asn Ile Glu 
        115                 120                 125             


Leu Asp Pro Arg Phe Asn Asp Ile Leu Gly Arg His Ser Arg Lys Arg 
    130                 135                 140                 


Trp Glu Arg Phe Val His Ser Glu Asn Gln His Leu Val Ser Pro Glu 
145                 150                 155                 160 


Ala Leu Asp Phe Leu Asp Lys Leu Leu Arg Tyr Asp His Gln Ser Arg 
                165                 170                 175     


Leu Thr Ala Arg Glu Ala Met Glu His Pro Tyr Phe Tyr Thr Val Val 
            180                 185                 190         


Lys Asp Gln Ala Arg Met Gly Ser Ser Ser Met Pro Gly Gly Ser Thr 
        195                 200                 205             


Pro Val Ser Ser Ala Asn Met Met Ser Gly Ile Ser Ser Val Pro Thr 
    210                 215                 220                 


Pro Ser Pro Leu Gly Pro Leu Ala Gly Ser Pro Val Ile Ala Ala Ala 
225                 230                 235                 240 


Asn Pro Leu Gly Met Pro Val Pro Ala Ala Ala Gly Ala Gln Gln 
                245                 250                 255 


<210>  26
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Thr Asp Val Asn 
1               5                   10                  15      


Thr His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg Gly 
        35                  40                  45              


Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Thr Asn Asn Glu Lys 
    50                  55                  60                  


Val Val Val Lys Ile Leu Lys Pro Val Lys Lys Lys Lys Ile Lys Arg 
65                  70                  75                  80  


Glu Ile Lys Ile Leu Glu Asn Leu Arg Gly Gly Pro Asn Ile Ile Thr 
                85                  90                  95      


Leu Ala Asp Ile Val Lys Asp Pro Val Ser Arg Thr Pro Ala Leu Val 
            100                 105                 110         


Phe Glu His Val Asn Asn Thr Asp Phe Lys Gln Leu Tyr Gln Thr Leu 
        115                 120                 125             


Thr Asp Tyr Asp Ile Arg Phe Tyr Met Tyr Glu Ile Leu Lys Ala Leu 
    130                 135                 140                 


Asp Tyr Cys His Ser Met Gly Ile Met His Arg Asp Val Lys Pro His 
145                 150                 155                 160 


Asn Val Met Ile Asp His Glu His Arg Lys Leu Arg Leu Ile Asp Trp 
                165                 170                 175     


Gly Leu Ala Glu Phe Tyr His Pro Gly Gln Glu Tyr Asn Val Arg Val 
            180                 185                 190         


Ala Ser Arg Tyr Phe Lys Gly Pro Glu Leu Leu Val Asp Tyr Gln Met 
        195                 200                 205             


Tyr Asp Tyr Ser Leu Asp Met Trp Ser Leu Gly Cys Met Leu Ala Ser 
    210                 215                 220                 


Met Ile Phe Arg Lys Glu Pro Phe Phe His Gly His Asp Asn Tyr Asp 
225                 230                 235                 240 


Gln Leu Val Arg Ile Ala Lys Val Leu Gly Thr Glu Asp Leu Tyr Asp 
                245                 250                 255     


Tyr Ile Asp Lys Tyr Asn Ile Glu Leu Asp Pro Arg Phe Asn Asp Ile 
            260                 265                 270         


Leu Gly Arg His Ser Arg Lys Arg Trp Glu Arg Phe Val His Ser Glu 
        275                 280                 285             


Asn Gln His Leu Val Ser Pro Glu Ala Leu Asp Phe Leu Asp Lys Leu 
    290                 295                 300                 


Leu Arg Tyr Asp His Gln Ser Arg Leu Thr Ala Arg Glu Ala Met Glu 
305                 310                 315                 320 


His Pro Tyr Phe Tyr Thr Val Val Lys Asp Gln Ala Arg Met Gly Ser 
                325                 330                 335     


Ser Ser Met Pro Gly Gly Ser Thr Pro Val Ser Ser Ala Asn Met Met 
            340                 345                 350         


Ser Glu Met Lys Phe Cys Arg Val Ala Gln Ala Gly Leu Glu Leu Leu 
        355                 360                 365             


Ser Ser Thr Val Tyr Pro Pro Trp Pro Pro Lys Val Leu Arg Leu Glu 
    370                 375                 380                 


Ala 
385 


<210>  27
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Tyr Glu Ile Leu Lys Ala Leu Asp Tyr Cys His Ser Met Gly Ile 
1               5                   10                  15      


Met His Arg Asp Val Lys Pro His Asn Val Met Ile Asp His Glu His 
            20                  25                  30          


Arg Lys Leu Arg Leu Ile Asp Trp Gly Leu Ala 
        35                  40              


<210>  28
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Thr Asp Val Asn 
1               5                   10                  15      


Thr His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg Gly 
        35                  40                  45              


Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Thr Asn Asn Glu Lys 
    50                  55                  60                  


Val Val Val Lys Ile Leu Lys Pro Val Lys Lys Lys Lys Ile Lys Arg 
65                  70                  75                  80  


Glu Ile Lys Ile Leu Glu Asn Leu Arg Gly Gly Pro Asn Ile Ile Thr 
                85                  90                  95      


Leu Ala Asp Ile Val Lys Asp Pro Val Ala Lys Arg Leu Ile Ala Leu 
            100                 105                 110         


Glu Thr Glu Met Cys 
        115         


<210>  29
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Thr Asp Val Asn 
1               5                   10                  15      


Thr His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg Gly 
        35                  40                  45              


Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Thr Asn Asn Glu Lys 
    50                  55                  60                  


Val Val Val Lys Ile Leu Lys Pro Val Lys Lys Lys Lys Ile Lys Arg 
65                  70                  75                  80  


Glu Ile Lys Ile Leu Glu Asn Leu Arg Gly Gly Pro Asn Ile Ile Thr 
                85                  90                  95      


Leu Ala Asp Ile Val Lys Asp Pro Val Ser Arg Thr Pro Ala Leu Val 
            100                 105                 110         


Phe Glu His Val Asn Asn Thr Asp Phe Lys Gln Leu Tyr Gln Thr Leu 
        115                 120                 125             


Thr Asp Tyr Asp Ile 
    130             


<210>  30
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Thr Asp Val Asn 
1               5                   10                  15      


Thr His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg Gly 
        35                  40                  45              


Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Thr Asn Asn Glu Lys 
    50                  55                  60                  


Val Val Val Lys Ile Leu Lys Pro Val Lys 
65                  70                  


<210>  31
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Thr Asp Val Asn 
1               5                   10                  15      


Thr His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg Gly 
        35                  40                  45              


Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Thr Asn Asn Glu Lys 
    50                  55                  60                  


Val Val Val Lys Ile Leu Lys Pro Val Lys Lys Lys Lys Ile Lys Arg 
65                  70                  75                  80  


Glu Ile Lys Ile Leu Glu Asn Leu Arg Gly Gly Pro Asn Ile Ile Thr 
                85                  90                  95      


Leu Ala Asp Ile Val Lys Asp Pro Val Ser Arg Thr Pro Ala Leu Val 
            100                 105                 110         


Phe Glu His Val Asn Asn Thr Asp Phe Lys Gln Leu Tyr Gln Thr Leu 
        115                 120                 125             


Thr Asp Tyr Asp Ile Arg Phe Tyr Met Tyr Glu Ile Leu Lys Ala Leu 
    130                 135                 140                 


Asp Tyr Cys His Ser Met Gly Ile Met His Arg Asp Val Lys Pro His 
145                 150                 155                 160 


Asn Val Met Ile Asp His Glu His Arg Lys Leu Arg Leu Ile Asp Trp 
                165                 170                 175     


Gly Leu Ala Glu Phe Tyr His Pro Gly Gln Glu Tyr Asn Val Arg Val 
            180                 185                 190         


Ala Ser Arg Tyr Phe Lys Gly Pro Glu Leu Leu Val Asp Tyr Gln 
        195                 200                 205         


<210>  32
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Thr Asp Val Asn 
1               5                   10                  15      


Thr His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg Gly 
        35                  40                  45              


Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Thr Asn Asn Glu Lys 
    50                  55                  60                  


Val Val Val Lys Ile Leu Lys Tyr Leu Leu Phe Thr Thr Ala Thr Thr 
65                  70                  75                  80  


Ala Asn Pro Ala Ser Gln Lys Tyr Ala Ile Ala Arg Ser Ile Thr Gln 
                85                  90                  95      


Ser Ile Thr Arg Ser Val Thr Gln Ser Asn Val Glu Thr Thr Asn His 
            100                 105                 110         


Leu Lys Leu Ala Val His Pro Val Ser Gly Arg Phe Asn Asp Gly Leu 
        115                 120                 125             


Met Cys Leu Pro Gln Lys Cys Lys Val Phe His Ser Ile Pro Val His 
    130                 135                 140                 


Cys Trp Gly Ala Ser His Ala Leu 
145                 150         


<210>  33
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Thr Asp Val Asn 
1               5                   10                  15      


Thr His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg Gly 
        35                  40                  45              


Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Thr Asn Asn Glu Lys 
    50                  55                  60                  


Val Val Val Lys Ile Leu Lys Ser Arg Thr Pro Ala Leu Val Phe Glu 
65                  70                  75                  80  


His Val Asn Asn Thr Asp Phe Lys Gln Leu Tyr Gln Thr Leu Thr Asp 
                85                  90                  95      


Tyr Asp Ile Arg Phe Tyr Met Tyr Glu Ile Leu Lys Ala Leu Asp Tyr 
            100                 105                 110         


Cys His Ser Met Gly Ile Met His Arg Asp Val Lys Pro His Asn Val 
        115                 120                 125             


Met Ile Asp 
    130     


<210>  34
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Thr Asp Val Asn 
1               5                   10                  15      


Thr His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg Gly 
        35                  40                  45              


Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Thr Asn Asn Glu Lys 
    50                  55                  60                  


Val Val Val Lys Ile Leu Lys Val Ser Thr Arg Asp Asn Phe Arg Gly 
65                  70                  75                  80  


Ile Trp Asn Ile Asp Phe 
                85      


<210>  35
<211>  363
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Thr Asp Val Asn 
1               5                   10                  15      


Thr His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg Gly 
        35                  40                  45              


Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Thr Asn Asn Glu Lys 
    50                  55                  60                  


Val Val Val Lys Ile Leu Lys Pro Val Lys Lys Lys Lys Ile Lys Arg 
65                  70                  75                  80  


Glu Ile Lys Ile Leu Glu Asn Leu Arg Gly Gly Pro Asn Ile Ile Thr 
                85                  90                  95      


Leu Ala Asp Ile Val Lys Asp Pro Val Ser Arg Thr Pro Ala Leu Val 
            100                 105                 110         


Phe Glu His Val Asn Asn Thr Asp Phe Lys Gln Leu Tyr Gln Thr Leu 
        115                 120                 125             


Thr Asp Tyr Asp Ile Arg Phe Tyr Met Tyr Glu Ile Leu Lys Leu Arg 
    130                 135                 140                 


Leu Ile Asp Trp Gly Leu Ala Glu Phe Tyr His Pro Gly Gln Glu Tyr 
145                 150                 155                 160 


Asn Val Arg Val Ala Ser Arg Tyr Phe Lys Gly Pro Glu Leu Leu Val 
                165                 170                 175     


Asp Tyr Gln Met Tyr Asp Tyr Ser Leu Asp Met Trp Ser Leu Gly Cys 
            180                 185                 190         


Met Leu Ala Ser Met Ile Phe Arg Lys Glu Pro Phe Phe His Gly His 
        195                 200                 205             


Asp Asn Tyr Asp Gln Leu Val Arg Ile Ala Lys Val Leu Gly Thr Glu 
    210                 215                 220                 


Asp Leu Tyr Asp Tyr Ile Asp Lys Tyr Asn Ile Glu Leu Asp Pro Arg 
225                 230                 235                 240 


Phe Asn Asp Ile Leu Gly Arg His Ser Arg Lys Arg Trp Glu Arg Phe 
                245                 250                 255     


Val His Ser Glu Asn Gln His Leu Val Ser Pro Glu Ala Leu Asp Phe 
            260                 265                 270         


Leu Asp Lys Leu Leu Arg Tyr Asp His Gln Ser Arg Leu Thr Ala Arg 
        275                 280                 285             


Glu Ala Met Glu His Pro Tyr Phe Tyr Thr Val Val Lys Asp Gln Ala 
    290                 295                 300                 


Arg Met Gly Ser Ser Ser Met Pro Gly Gly Ser Thr Pro Val Ser Ser 
305                 310                 315                 320 


Ala Asn Met Met Ser Gly Ile Ser Ser Val Pro Thr Pro Ser Pro Leu 
                325                 330                 335     


Gly Pro Leu Ala Gly Ser Pro Val Ile Ala Ala Ala Asn Pro Leu Gly 
            340                 345                 350         


Met Pro Val Pro Ala Ala Ala Gly Ala Gln Gln 
        355                 360             


<210>  36
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Thr Asp Val Asn 
1               5                   10                  15      


Thr His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg Gly 
        35                  40                  45              


Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Thr Asn Asn Glu Lys 
    50                  55                  60                  


Val Val Val Lys Ile Leu Lys Pro Val Lys Lys Lys Lys Ile Lys Arg 
65                  70                  75                  80  


Glu Ile Lys Ile Leu Glu Asn Leu Arg Gly Gly Pro Asn Ile Ile Thr 
                85                  90                  95      


Leu Ala Asp Ile Val Lys Asp Pro Val Gln Leu Tyr Gln Thr Leu Thr 
            100                 105                 110         


Asp Tyr Asp Ile Arg Phe Tyr Met Tyr Glu Ile Leu Lys Ala Leu Asp 
        115                 120                 125             


Tyr Cys His Ser Met Gly Ile Met His Arg Asp Val Lys Pro His Asn 
    130                 135                 140                 


Val Met Ile Asp His Glu His Arg Lys Leu Arg Leu Ile Asp Trp Gly 
145                 150                 155                 160 


Leu Ala Glu Phe Tyr His Pro Gly Gln Glu Tyr Asn Val Arg Val Ala 
                165                 170                 175     


Ser Arg Tyr Phe Lys Gly Pro Glu Leu Leu Val Asp Tyr Gln Met Tyr 
            180                 185                 190         


Asp Tyr Ser Leu Asp Met Trp Ser Leu Gly Cys Met Leu Ala Ser Met 
        195                 200                 205             


Ile Phe Arg Lys Glu Pro Phe Phe His Gly His Asp Asn Tyr Asp Gln 
    210                 215                 220                 


Leu Val Arg Ile Ala Lys Val Leu Gly Thr Glu Asp Leu Tyr Asp Tyr 
225                 230                 235                 240 


Ile Asp Lys Tyr Asn Ile Glu Leu Asp Pro Arg Phe Asn Asp Ile Leu 
                245                 250                 255     


Gly Arg His Ser Arg Lys Arg Trp Glu Arg Phe Val His Ser Glu Asn 
            260                 265                 270         


Gln His Leu Val Ser Pro Glu Ala Leu Asp Phe Leu Asp Lys Leu Leu 
        275                 280                 285             


Arg Tyr Asp His Gln Ser Arg Leu Thr Ala Arg Glu Ala Met Glu His 
    290                 295                 300                 


Pro Tyr Phe Tyr Thr Val Val Lys Asp Gln Ala Arg Met Gly Ser Ser 
305                 310                 315                 320 


Ser Met Pro Gly Gly Ser Thr Pro Val Ser Ser Ala Asn Met Met Ser 
                325                 330                 335     


Gly Ile Ser Ser Val Pro Thr Pro Ser Pro Leu Gly Pro Leu Ala Gly 
            340                 345                 350         


Ser Pro Val Ile Ala Ala Ala Asn Pro Leu Gly Met Pro Val Pro Ala 
        355                 360                 365             


Ala Ala Gly Ala Gln Gln 
    370                 


<210>  37
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Thr Asp Val Asn 
1               5                   10                  15      


Thr His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg Gly 
        35                  40                  45              


Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Thr Asn Asn Glu Lys 
    50                  55                  60                  


Val Val Val Lys Ile Leu Lys Tyr Leu Gln Asn Thr Trp His Ser Ala 
65                  70                  75                  80  


Arg Arg Arg Ile Gln Arg Arg Met 
                85              


<210>  38
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Thr Asp Val Asn 
1               5                   10                  15      


Thr His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly 
        


<210>  39
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Thr Asp Val Asn 
1               5                   10                  15      


Thr His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg Gly 
        35                  40                  45              


Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Thr Asn Asn Glu Lys 
    50                  55                  60                  


Val Val Val Lys Ile Leu Lys Pro Val Lys Lys Lys Lys Ile Lys Arg 
65                  70                  75                  80  


Glu Ile Lys Ile Leu Glu Asn Leu Arg Gly Gly Pro Asn Ile Ile Thr 
                85                  90                  95      


Leu Ala Asp Ile Val Lys Asp Pro Val Ser Arg Thr Pro Ala Leu Val 
            100                 105                 110         


Phe Glu His Val Asn Asn Thr Asp Phe Lys Gln Leu Tyr Gln Thr Leu 
        115                 120                 125             


Thr Asp Tyr Asp Ile Arg Phe Tyr Met Tyr Glu Ile Leu Lys Ala Leu 
    130                 135                 140                 


Asp Tyr Cys His Ser Met Gly Ile Met His Arg Asp Val Lys Pro His 
145                 150                 155                 160 


Asn Val Met Ile Asp His Glu His Arg Lys Leu Arg Leu Ile Asp Trp 
                165                 170                 175     


Gly Leu Ala Glu Phe Tyr His Pro Gly Gln Glu Tyr Asn Val Arg Val 
            180                 185                 190         


Ala Ser Arg Tyr Phe Lys Gly Pro Glu Leu Leu Val Asp Tyr Gln Met 
        195                 200                 205             


Tyr Asp Tyr Ser Leu Asp Met Trp Ser Leu Gly Cys Met Leu Ala Ser 
    210                 215                 220                 


Met Ile Phe Arg Lys Glu Pro Phe Phe His Gly His Asp Asn Tyr Asp 
225                 230                 235                 240 


Gln Val Ile Tyr Val Ile Pro Ile Glu Lys Cys Thr Gly Leu Met Gln 
                245                 250                 255     


<210>  40
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  40

Asp Tyr Ile Asp Lys Tyr Asn Ile Glu Leu Asp Pro Arg Phe Asn Asp 
1               5                   10                  15      


Ile Leu Gly Arg His Ser Arg Lys Arg Trp Glu Arg Phe Val His Ser 
            20                  25                  30          


Glu Asn Gln His Leu Val Ser Pro Glu Ala Leu Asp Phe Leu Asp Lys 
        35                  40                  45              


Leu Leu Arg Tyr Asp His Gln Ser Arg Leu Thr Ala Arg Glu Ala Met 
    50                  55                  60                  


Glu His Pro Tyr Phe Tyr Thr Val Val Lys Asp Gln Ala Arg Met Gly 
65                  70                  75                  80  


Ser Ser Ser Met Pro Gly Gly Ser Thr Pro Val Ser Ser Ala Asn Met 
                85                  90                  95      


Met Ser Glu Pro Gln Phe Glu Gly Gln Arg Asp Ile His His Ala Ala 
            100                 105                 110         


Val Arg Leu Gly Gln Leu 
        115             


<210>  41
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Thr Asp Val Asn 
1               5                   10                  15      


Thr His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg Gly 
        35                  40                  45              


Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Thr Asn Asn Glu Lys 
    50                  55                  60                  


Val Val Val Lys Ile Leu Lys Pro Val Lys Lys Lys Lys Ile Lys Arg 
65                  70                  75                  80  


Glu Ile Lys Ile Leu Glu Asn Leu Arg Gly Gly Pro Asn Ile Ile Thr 
                85                  90                  95      


Leu Ala Asp Ile Val Lys Asp Pro Val Ala Leu Asp Tyr Cys His Ser 
            100                 105                 110         


Met Gly Ile Met His Arg Asp Val Lys Pro His Asn Val Met Ile Asp 
        115                 120                 125             


His Glu His Arg Lys Leu Arg Leu Ile Asp Trp Gly Leu Ala Glu Phe 
    130                 135                 140                 


Tyr His Pro Gly Gln Glu Tyr Asn Val Arg Val Ala Ser Arg Tyr Phe 
145                 150                 155                 160 


Lys Gly Pro Glu Leu Leu Val Asp Tyr Gln Met Tyr Asp Tyr Ser Leu 
                165                 170                 175     


Asp Met Trp Ser Leu Gly Cys Met Leu Ala Ser Met Ile Phe Arg Lys 
            180                 185                 190         


Glu Pro Phe Phe His Gly His Asp Asn Tyr Asp Gln Leu Val Arg Ile 
        195                 200                 205             


Ala Lys Val Leu Gly Thr Glu Asp Leu Tyr Asp Tyr Ile Asp Lys Tyr 
    210                 215                 220                 


Asn Ile Glu Leu Asp Pro Arg Phe Asn Asp Ile Leu Gly Arg His Ser 
225                 230                 235                 240 


Arg Lys Arg Trp Glu Arg Phe Val His Ser Glu Asn Gln His Leu Val 
                245                 250                 255     


Ser Pro Glu Ala Leu Asp Phe Leu Asp Lys Leu Leu Arg Tyr Asp His 
            260                 265                 270         


Gln Ser Arg Leu Thr Ala Arg Glu Ala Met Glu His Pro Tyr Phe Tyr 
        275                 280                 285             


Thr Val Val Lys Asp Gln Ala Arg Met Gly Ser Ser Ser Met Pro Gly 
    290                 295                 300                 


Gly Ser Thr Pro Val Ser Ser Ala Asn Met Met Ser Gly Ile Ser Ser 
305                 310                 315                 320 


Val Pro Thr Pro Ser Pro Leu Gly Pro Leu Ala Gly Ser Pro Val Ile 
                325                 330                 335     


Ala Ala Ala Asn Pro Leu Gly Met Pro Val Pro Ala Ala Ala Gly Ala 
            340                 345                 350         


Gln Gln 
        


<210>  42
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Thr Asp Val Asn 
1               5                   10                  15      


Thr His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg Gly 
        35                  40                  45              


Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Thr Asn Asn Glu Lys 
    50                  55                  60                  


Val Val Val Lys Ile Leu Lys Pro Val Lys Lys Lys Lys Ile Lys Arg 
65                  70                  75                  80  


Glu Ile Lys Ile Leu Glu Asn Leu Arg Gly Gly Pro 
                85                  90          


<210>  43
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Thr Asp Val Asn 
1               5                   10                  15      


Thr His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg Gly 
        35                  40                  45              


Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Thr Asn Asn Glu Lys 
    50                  55                  60                  


Val Val Val Lys Ile Leu Lys Ser Gln Val Leu Glu Gly Leu Lys Trp 
65                  70                  75                  80  


Glu Asp Arg Leu Ser Leu Glu Val Glu Gly Cys Thr Asp Leu 
                85                  90                  


<210>  44
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Thr Asp Val Asn 
1               5                   10                  15      


Thr His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg Gly 
        35                  40                  45              


Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Thr Asn Asn Glu Lys 
    50                  55                  60                  


Val Val Val Lys Ile Leu Lys Pro Val Lys Lys Lys Lys Ile Lys Arg 
65                  70                  75                  80  


Glu Ile Lys Ile Leu Glu Asn Leu Arg Gly Gly Pro Asn Ile Ile Thr 
                85                  90                  95      


Leu Ala Asp Ile Val Lys Asp Pro Val Ser Arg Thr Pro Ala Leu Val 
            100                 105                 110         


Phe Glu His Val Asn Asn Thr Asp Phe Lys Gln Leu Tyr Gln Thr Leu 
        115                 120                 125             


Thr Asp Tyr Asp Ile Arg Phe Tyr Met Tyr Glu Ile Leu Lys Ala Leu 
    130                 135                 140                 


Asp Tyr Cys His Ser Met Gly Ile Met His Arg Asp Val Lys Pro His 
145                 150                 155                 160 


Asn Val Met Ile Asp His Glu His Arg Lys Met Tyr Asp Tyr Ser Leu 
                165                 170                 175     


Asp Met Trp Ser Leu Gly Cys Met Leu Ala Ser Met Ile Phe Arg Lys 
            180                 185                 190         


Glu Pro Phe Phe His Gly His Asp Asn Tyr Asp Gln Leu Val Arg Ile 
        195                 200                 205             


Ala Lys Val Leu Gly Thr Glu Asp Leu Tyr Asp Tyr Ile Asp Lys Tyr 
    210                 215                 220                 


Asn Ile Glu Leu Asp Pro Arg Phe Asn Asp Ile Leu Gly Arg His Ser 
225                 230                 235                 240 


Arg Lys Arg Trp Glu Arg Phe Val His Ser Glu Asn Gln His Leu Val 
                245                 250                 255     


Ser Pro Glu Ala Leu Asp Phe Leu Asp Lys Leu Leu Arg Tyr Asp His 
            260                 265                 270         


Gln Ser Arg Leu Thr Ala Arg Glu Ala Met Glu His Pro Tyr Phe Tyr 
        275                 280                 285             


Thr Val Val Lys Asp Gln Ala Arg Met Gly Ser Ser Ser Met Pro Gly 
    290                 295                 300                 


Gly Ser Thr Pro Val Ser Ser Ala Asn Met Met Ser Gly Ile Ser Ser 
305                 310                 315                 320 


Val Pro Thr Pro Ser Pro Leu Gly Pro Leu Ala Gly Ser Pro Val Ile 
                325                 330                 335     


Ala Ala Ala Asn Pro Leu Gly Met Pro Val Pro Ala Ala Ala Gly Ala 
            340                 345                 350         


Gln Gln 
        


<210>  45
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Thr Asp Val Asn 
1               5                   10                  15      


Thr His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg Gly 
        35                  40                  45              


Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Thr Asn Asn Glu Lys 
    50                  55                  60                  


Val Val Val Lys Ile Leu Lys Pro Val Lys Lys Lys Lys Ile Lys Arg 
65                  70                  75                  80  


Glu Ile Lys Ile Leu Glu Asn Leu Arg Gly Gly Pro Asn Ile Ile Thr 
                85                  90                  95      


Leu Ala Asp Ile Val Lys Asp Pro Val Ser Arg Thr Pro Ala Leu Val 
            100                 105                 110         


Phe Glu His Val Asn Asn Thr Asp Phe Lys Gln Leu Tyr Gln Thr Leu 
        115                 120                 125             


Thr Asp Tyr Asp Ile Arg Phe Tyr Met Tyr Glu Ile Leu Lys Ala Leu 
    130                 135                 140                 


Asp Tyr Cys His Ser Met Gly Ile Met His Arg Asp Val Lys Pro His 
145                 150                 155                 160 


Asn Val Met Ile Asp His Glu His Arg Lys Leu Arg Leu Ile Asp Trp 
                165                 170                 175     


Gly Leu Ala Glu Phe Tyr His Pro Gly Gln Glu Tyr Asn Val Arg Val 
            180                 185                 190         


Ala Ser Arg Tyr Phe Lys Gly Pro Glu Leu Leu Val Asp Tyr Gln Met 
        195                 200                 205             


Tyr Asp Tyr Ser Leu Asp Met Trp Ser Leu Gly Cys Met Leu Ala Ser 
    210                 215                 220                 


Met Ile Phe Arg Lys Glu Pro Phe Phe His Gly His Asp Asn Tyr Asp 
225                 230                 235                 240 


Gln Leu Val Arg Ile Ala Lys Val Leu Gly Thr Glu Asp Leu Tyr Asp 
                245                 250                 255     


Tyr Ile Asp Lys Tyr Asn Ile Glu Leu Asp Pro Arg Phe Asn Asp Ile 
            260                 265                 270         


Leu Gly Arg His Ser Arg Lys Arg Trp Glu Arg Phe Val His Ser Glu 
        275                 280                 285             


Asn Gln His Leu Val Ser Pro Glu Ala Leu Asp Phe Leu Asp Lys Leu 
    290                 295                 300                 


Leu Arg Tyr Asp His Gln Ser Arg Leu Thr Ala Arg Glu Ala Met Glu 
305                 310                 315                 320 


His Pro Tyr Phe Tyr Thr Val Val Lys Asp Gln Ala Arg Met Gly Ser 
                325                 330                 335     


Ser Ser Met Pro Gly Gly Ser Thr Pro Val Ser Ser Ala Asn Met Met 
            340                 345                 350         


Ser Ala Leu Phe Phe Gln Gly Phe Leu Gln Cys Gln Pro Leu His Pro 
        355                 360                 365             


Leu Asp Leu Trp Gln Ala His Gln 
    370                 375     


<210>  46
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Thr Asp Val Asn 
1               5                   10                  15      


Thr His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg Gly 
        35                  40                  45              


Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Thr Asn Asn Glu Lys 
    50                  55                  60                  


Val Val Val Lys Ile Leu Lys Pro Val Lys Lys Lys Lys Ile Lys Arg 
65                  70                  75                  80  


Glu Ile Lys Ile Leu Glu Asn Leu Arg Gly Gly Pro Asn Ile Ile Thr 
                85                  90                  95      


Leu Ala Asp Ile Val Lys Asp Pro Val Ser Arg Thr Pro Ala Leu Val 
            100                 105                 110         


Phe Glu His Val Asn Asn Thr Asp Phe Lys Gln Leu Tyr Gln Thr Leu 
        115                 120                 125             


Thr Asp Tyr Asp Ile Arg Phe Tyr Met Tyr Glu Ile Leu Lys Ala Leu 
    130                 135                 140                 


<210>  47
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Glu Pro Trp Pro Cys Ser Pro Gly Gly Gly Gly Gly Thr Arg Ala 
1               5                   10                  15      


Arg His Val Ile Ile Asn Val Gly Gly Cys Arg Val Arg Leu Ala Trp 
            20                  25                  30          


Ala Ala Leu Ala Arg Cys Pro Leu Ala Arg Leu Glu Arg Leu Arg Ala 
        35                  40                  45              


Cys Arg Gly His Asp Asp Leu Leu Arg Val Cys Asp Asp Tyr Asp Val 
    50                  55                  60                  


Ser Arg Asp Glu Phe Phe Phe Asp Arg Ser Pro Cys Ala Phe Arg Ala 
65                  70                  75                  80  


Ile Val Ala Leu Leu Arg Ala Gly Lys Leu Arg Leu Leu Arg Gly Pro 
                85                  90                  95      


Cys Ala Leu Ala Phe Arg Asp Glu Leu Ala Tyr Trp Gly Ile Asp Glu 
            100                 105                 110         


Ala Arg Leu Glu Arg Cys Cys Leu Arg Arg Leu Arg Arg Arg Glu Glu 
        115                 120                 125             


Glu Ala Ala Glu Ala Arg Ala Gly Pro Thr Glu Arg Gly Ala Gln Gly 
    130                 135                 140                 


Ser Pro Ala Arg Ala Leu Gly Pro Arg Gly Arg Leu Gln Arg Gly Arg 
145                 150                 155                 160 


Arg Arg Leu Arg Asp Val Val Asp Asn Pro His Ser Gly Leu Ala Gly 
                165                 170                 175     


Lys Leu Phe Ala Cys Val Ser Val Ser Phe Val Ala Val Thr Ala Val 
            180                 185                 190         


Gly Leu Cys Leu Ser Thr Met Pro Asp Ile Arg Ala Glu Glu Glu Arg 
        195                 200                 205             


Gly Glu Cys Ser Pro Lys Cys Arg Ser Leu Phe Val Leu Glu Thr Val 
    210                 215                 220                 


Cys Val Ala Trp Phe Ser Phe Glu Phe Leu Leu Arg Ser Leu Gln Ala 
225                 230                 235                 240 


Glu Ser Lys Cys Ala Phe Leu Arg Ala Pro Leu Asn Ile Ile Asp Ile 
                245                 250                 255     


Leu Ala Leu Leu Pro Phe Tyr Val Ser Leu Leu Leu Gly Leu Ala Ala 
            260                 265                 270         


Gly Pro Gly Gly Thr Lys Leu Leu Glu Arg Ala Gly Leu Val Leu Arg 
        275                 280                 285             


Leu Leu Arg Ala Leu Arg Val Leu Tyr Val Met Arg Leu Ala Arg His 
    290                 295                 300                 


Ser Leu Gly Leu Arg Ser Leu Gly Leu Thr Met Arg Arg Cys Ala Arg 
305                 310                 315                 320 


Glu Phe Gly Leu Leu Leu Leu Phe Leu Cys Val Ala Met Ala Leu Phe 
                325                 330                 335     


Ala Pro Leu Val His Leu Ala Glu Arg Glu Leu Gly Ala Arg Arg Asp 
            340                 345                 350         


Phe Ser Ser Val Pro Ala Ser Tyr Trp Trp Ala Val Ile Ser Met Thr 
        355                 360                 365             


Thr Val Gly Tyr Gly Asp Met Val Pro Arg Ser Leu Pro Gly Gln Val 
    370                 375                 380                 


Val Ala Leu Ser Ser Ile Leu Ser Gly Ile Leu Leu Met Ala Phe Pro 
385                 390                 395                 400 


Val Thr Ser Ile Phe His Thr Phe Ser Arg Ser Tyr Ser Glu Leu Lys 
                405                 410                 415     


Glu Gln Gln Gln Arg Ala Ala Ser Pro Glu Pro Ala Leu Gln Glu Asp 
            420                 425                 430         


Ser Thr His Ser Ala Thr Ala Thr Glu Asp Ser Ser Gln Gly Pro Asp 
        435                 440                 445             


Ser Ala Gly Leu Ala Asp Asp Ser Ala Asp Ala Leu Trp Val Arg Ala 
    450                 455                 460                 


Gly Arg 
465     


<210>  48
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ala Gln Glu Lys Met Glu Leu Asp Leu Glu Leu Pro Pro Gly Thr 
1               5                   10                  15      


Gly Gly Ser Pro Ala Glu Gly Gly Gly Ser Gly Gly Gly Gly Gly Leu 
            20                  25                  30          


Arg Arg Ser Asn Ser Ala Pro Leu Ile His Gly Leu Ser Asp Thr Ser 
        35                  40                  45              


Pro Val Phe Gln Ala Glu Ala Pro Ser Ala Arg Arg Asn Ser Thr Thr 
    50                  55                  60                  


Phe Pro Ser Arg His Gly Leu Leu Leu Pro Ala Ser Pro Val Arg Met 
65                  70                  75                  80  


His Ser Ser Arg Leu His Gln Ile Lys Gln Glu Glu Gly Met Asp Leu 
                85                  90                  95      


Ile Asn Arg Glu Thr Val His Glu Arg Glu Val Gln Thr Ala Met Gln 
            100                 105                 110         


Ile Ser His Ser Trp Glu Glu Ser Phe Ser Leu Ser Asp Asn Asp Val 
        115                 120                 125             


Glu Lys Ser Ala Ser Pro Lys Arg Ile Asp Phe Ile Pro Val Ser Pro 
    130                 135                 140                 


Ala Pro Ser Pro Thr Arg Gly Ile Gly Lys Gln Cys Phe Ser Pro Ser 
145                 150                 155                 160 


Leu Gln Ser Phe Val Ser Ser Asn Gly Leu Pro Pro Ser Pro Ile Pro 
                165                 170                 175     


Ser Pro Thr Thr Arg Phe Thr Thr Arg Arg Ser Gln Ser Pro Ile Asn 
            180                 185                 190         


Cys Ile Arg Pro Ser Val Leu Gly Pro Leu Lys Arg Lys Cys Glu Met 
        195                 200                 205             


Glu Thr Glu Tyr Gln Pro Lys Arg Phe Phe Gln Gly Ile Thr Asn Met 
    210                 215                 220                 


Leu Ser Ser Asp Val Ala Gln Leu Ser Asp Pro Gly Val Cys Val Ser 
225                 230                 235                 240 


Ser Asp Thr Leu Asp Gly Asn Ser Ser Ser Ala Gly Ser Ser Cys Asn 
                245                 250                 255     


Ser Pro Ala Lys Val Ser Thr Thr Thr Asp Ser Pro Val Ser Pro Ala 
            260                 265                 270         


Gln Ala Ala Ser Pro Phe Ile Pro Leu Asp Glu Leu Ser Ser Lys 
        275                 280                 285         


<210>  49
<211>  3065
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Glu Glu Lys Gln Gln Ile Ile Leu Ala Asn Gln Asp Gly Gly Thr 
1               5                   10                  15      


Val Ala Gly Ala Ala Pro Thr Phe Phe Val Ile Leu Lys Gln Pro Gly 
            20                  25                  30          


Asn Gly Lys Thr Asp Gln Gly Ile Leu Val Thr Asn Gln Asp Ala Cys 
        35                  40                  45              


Ala Leu Ala Ser Ser Val Ser Ser Pro Val Lys Ser Lys Gly Lys Ile 
    50                  55                  60                  


Cys Leu Pro Ala Asp Cys Thr Val Gly Gly Ile Thr Val Thr Leu Asp 
65                  70                  75                  80  


Asn Asn Ser Met Trp Asn Glu Phe Tyr His Arg Ser Thr Glu Met Ile 
                85                  90                  95      


Leu Thr Lys Gln Gly Arg Arg Met Phe Pro Tyr Cys Arg Tyr Trp Ile 
            100                 105                 110         


Thr Gly Leu Asp Ser Asn Leu Lys Tyr Ile Leu Val Met Asp Ile Ser 
        115                 120                 125             


Pro Val Asp Asn His Arg Tyr Lys Trp Asn Gly Arg Trp Trp Glu Pro 
    130                 135                 140                 


Ser Gly Lys Ala Glu Pro His Val Leu Gly Arg Val Phe Ile His Pro 
145                 150                 155                 160 


Glu Ser Pro Ser Thr Gly His Tyr Trp Met His Gln Pro Val Ser Phe 
                165                 170                 175     


Tyr Lys Leu Lys Leu Thr Asn Asn Thr Leu Asp Gln Glu Gly His Ile 
            180                 185                 190         


Ile Leu His Ser Met His Arg Tyr Leu Pro Arg Leu His Leu Val Pro 
        195                 200                 205             


Ala Glu Lys Ala Val Glu Val Ile Gln Leu Asn Gly Pro Gly Val His 
    210                 215                 220                 


Thr Phe Thr Phe Pro Gln Thr Glu Phe Phe Ala Val Thr Ala Tyr Gln 
225                 230                 235                 240 


Asn Ile Gln Ile Thr Gln Leu Lys Ile Asp Tyr Asn Pro Phe Ala Lys 
                245                 250                 255     


Gly Phe Arg Asp Asp Gly Leu Asn Asn Lys Pro Gln Arg Asp Gly Lys 
            260                 265                 270         


Gln Lys Asn Ser Ser Asp Gln Glu Gly Asn Asn Ile Ser Ser Ser Ser 
        275                 280                 285             


Gly His Arg Val Arg Leu Thr Glu Gly Gln Gly Ser Glu Ile Gln Pro 
    290                 295                 300                 


Gly Asp Leu Asp Pro Leu Ser Arg Gly His Glu Thr Ser Gly Lys Gly 
305                 310                 315                 320 


Leu Glu Lys Thr Ser Leu Asn Ile Lys Arg Asp Phe Leu Gly Phe Met 
                325                 330                 335     


Asp Thr Asp Ser Ala Leu Ser Glu Val Pro Gln Leu Lys Gln Glu Ile 
            340                 345                 350         


Ser Glu Cys Leu Ile Ala Ser Ser Phe Glu Asp Asp Ser Arg Val Ala 
        355                 360                 365             


Ser Pro Leu Asp Gln Asn Gly Ser Phe Asn Val Val Ile Lys Glu Glu 
    370                 375                 380                 


Pro Leu Asp Asp Tyr Asp Tyr Glu Leu Gly Glu Cys Pro Glu Gly Val 
385                 390                 395                 400 


Thr Val Lys Gln Glu Glu Thr Asp Glu Glu Thr Asp Val Tyr Ser Asn 
                405                 410                 415     


Ser Asp Asp Asp Pro Ile Leu Glu Lys Gln Leu Lys Arg His Asn Lys 
            420                 425                 430         


Val Asp Asn Pro Glu Ala Asp His Leu Ser Ser Lys Trp Leu Pro Ser 
        435                 440                 445             


Ser Pro Ser Gly Val Ala Lys Ala Lys Met Phe Lys Leu Asp Thr Gly 
    450                 455                 460                 


Lys Met Pro Val Val Tyr Leu Glu Pro Cys Ala Val Thr Arg Ser Thr 
465                 470                 475                 480 


Val Lys Ile Ser Glu Leu Pro Asp Asn Met Leu Ser Thr Ser Arg Lys 
                485                 490                 495     


Asp Lys Ser Ser Met Leu Ala Glu Leu Glu Tyr Leu Pro Thr Tyr Ile 
            500                 505                 510         


Glu Asn Ser Asn Glu Thr Ala Phe Cys Leu Gly Lys Glu Ser Glu Asn 
        515                 520                 525             


Gly Leu Arg Lys His Ser Pro Asp Leu Arg Val Val Gln Lys Tyr Pro 
    530                 535                 540                 


Leu Leu Lys Glu Pro Gln Trp Lys Tyr Pro Asp Ile Ser Asp Ser Ile 
545                 550                 555                 560 


Ser Thr Glu Arg Ile Leu Asp Asp Ser Lys Asp Ser Val Gly Asp Ser 
                565                 570                 575     


Leu Ser Gly Lys Glu Asp Leu Gly Arg Lys Arg Thr Thr Met Leu Lys 
            580                 585                 590         


Ile Ala Thr Ala Ala Lys Val Val Asn Ala Asn Gln Asn Ala Ser Pro 
        595                 600                 605             


Asn Val Pro Gly Lys Arg Gly Arg Pro Arg Lys Leu Lys Leu Cys Lys 
    610                 615                 620                 


Ala Gly Arg Pro Pro Lys Asn Thr Gly Lys Ser Leu Ile Ser Thr Lys 
625                 630                 635                 640 


Asn Thr Pro Val Ser Pro Gly Ser Thr Phe Pro Asp Val Lys Pro Asp 
                645                 650                 655     


Leu Glu Asp Val Asp Gly Val Leu Phe Val Ser Phe Glu Ser Lys Glu 
            660                 665                 670         


Ala Leu Asp Ile His Ala Val Asp Gly Thr Thr Glu Glu Ser Ser Ser 
        675                 680                 685             


Leu Gln Ala Ser Thr Thr Asn Asp Ser Gly Tyr Arg Ala Arg Ile Ser 
    690                 695                 700                 


Gln Leu Glu Lys Glu Leu Ile Glu Asp Leu Lys Thr Leu Arg His Lys 
705                 710                 715                 720 


Gln Val Ile His Pro Gly Leu Gln Glu Val Gly Leu Lys Leu Asn Ser 
                725                 730                 735     


Val Asp Pro Thr Met Ser Ile Asp Leu Lys Tyr Leu Gly Val Gln Leu 
            740                 745                 750         


Pro Leu Ala Pro Ala Thr Ser Phe Pro Phe Trp Asn Leu Thr Gly Thr 
        755                 760                 765             


Asn Pro Ala Ser Pro Asp Ala Gly Phe Pro Phe Val Ser Arg Thr Gly 
    770                 775                 780                 


Lys Thr Asn Asp Phe Thr Lys Ile Lys Gly Trp Arg Gly Lys Phe His 
785                 790                 795                 800 


Ser Ala Ser Ala Ser Arg Asn Glu Gly Gly Asn Ser Glu Ser Ser Leu 
                805                 810                 815     


Lys Asn Arg Ser Ala Phe Cys Ser Asp Lys Leu Asp Glu Tyr Leu Glu 
            820                 825                 830         


Asn Glu Gly Lys Leu Met Glu Thr Ser Met Gly Phe Ser Ser Asn Ala 
        835                 840                 845             


Pro Thr Ser Pro Val Val Tyr Gln Leu Pro Thr Lys Ser Thr Ser Tyr 
    850                 855                 860                 


Val Arg Thr Leu Asp Ser Val Leu Lys Lys Gln Ser Thr Ile Ser Pro 
865                 870                 875                 880 


Ser Thr Ser Tyr Ser Leu Lys Pro His Ser Val Pro Pro Val Ser Arg 
                885                 890                 895     


Lys Ala Lys Ser Gln Asn Arg Gln Ala Thr Phe Ser Gly Arg Thr Lys 
            900                 905                 910         


Ser Ser Tyr Lys Ser Ile Leu Pro Tyr Pro Val Ser Pro Lys Gln Lys 
        915                 920                 925             


Tyr Ser His Val Ile Leu Gly Asp Lys Val Thr Lys Asn Ser Ser Gly 
    930                 935                 940                 


Ile Ile Ser Glu Asn Gln Ala Asn Asn Phe Val Val Pro Thr Leu Asp 
945                 950                 955                 960 


Glu Asn Ile Phe Pro Lys Gln Ile Ser Leu Arg Gln Ala Gln Gln Gln 
                965                 970                 975     


Gln Gln Gln Gln Gln Gly Ser Arg Pro Pro Gly Leu Ser Lys Ser Gln 
            980                 985                 990         


Val Lys Leu Met Asp Leu Glu Asp  Cys Ala Leu Trp Glu  Gly Lys Pro 
        995                 1000                 1005             


Arg Thr  Tyr Ile Thr Glu Glu  Arg Ala Asp Val Ser  Leu Thr Thr 
    1010                 1015                 1020             


Leu Leu  Thr Ala Gln Ala Ser  Leu Lys Thr Lys Pro  Ile His Thr 
    1025                 1030                 1035             


Ile Ile  Arg Lys Arg Ala Pro  Pro Cys Asn Asn Asp  Phe Cys Arg 
    1040                 1045                 1050             


Leu Gly  Cys Val Cys Ser Ser  Leu Ala Leu Glu Lys  Arg Gln Pro 
    1055                 1060                 1065             


Ala His  Cys Arg Arg Pro Asp  Cys Met Phe Gly Cys  Thr Cys Leu 
    1070                 1075                 1080             


Lys Arg  Lys Val Val Leu Val  Lys Gly Gly Ser Lys  Thr Lys His 
    1085                 1090                 1095             


Phe Gln  Arg Lys Ala Ala His  Arg Asp Pro Val Phe  Tyr Asp Thr 
    1100                 1105                 1110             


Leu Gly  Glu Glu Ala Arg Glu  Glu Glu Glu Gly Ile  Arg Glu Glu 
    1115                 1120                 1125             


Glu Glu  Gln Leu Lys Glu Lys  Lys Lys Arg Lys Lys  Leu Glu Tyr 
    1130                 1135                 1140             


Thr Ile  Cys Glu Thr Glu Pro  Glu Gln Pro Val Arg  His Tyr Pro 
    1145                 1150                 1155             


Leu Trp  Val Lys Val Glu Gly  Glu Val Asp Pro Glu  Pro Val Tyr 
    1160                 1165                 1170             


Ile Pro  Thr Pro Ser Val Ile  Glu Pro Met Lys Pro  Leu Leu Leu 
    1175                 1180                 1185             


Pro Gln  Pro Glu Val Leu Ser  Pro Thr Val Lys Gly  Lys Leu Leu 
    1190                 1195                 1200             


Thr Gly  Ile Lys Ser Pro Arg  Ser Tyr Thr Pro Lys  Pro Asn Pro 
    1205                 1210                 1215             


Val Ile  Arg Glu Glu Asp Lys  Asp Pro Val Tyr Leu  Tyr Phe Glu 
    1220                 1225                 1230             


Ser Met  Met Thr Cys Ala Arg  Val Arg Val Tyr Glu  Arg Lys Lys 
    1235                 1240                 1245             


Glu Asp  Gln Arg Gln Pro Ser  Ser Ser Ser Ser Pro  Ser Pro Ser 
    1250                 1255                 1260             


Phe Gln  Gln Gln Thr Ser Cys  His Ser Ser Pro Glu  Asn His Asn 
    1265                 1270                 1275             


Asn Ala  Lys Glu Pro Asp Ser  Glu Gln Gln Pro Leu  Lys Gln Leu 
    1280                 1285                 1290             


Thr Cys  Asp Leu Glu Asp Asp  Ser Asp Lys Leu Gln  Glu Lys Ser 
    1295                 1300                 1305             


Trp Lys  Ser Ser Cys Asn Glu  Gly Glu Ser Ser Ser  Thr Ser Tyr 
    1310                 1315                 1320             


Met His  Gln Arg Ser Pro Gly  Gly Pro Thr Lys Leu  Ile Glu Ile 
    1325                 1330                 1335             


Ile Ser  Asp Cys Asn Trp Glu  Glu Asp Arg Asn Lys  Ile Leu Ser 
    1340                 1345                 1350             


Ile Leu  Ser Gln His Ile Asn  Ser Asn Met Pro Gln  Ser Leu Lys 
    1355                 1360                 1365             


Val Gly  Ser Phe Ile Ile Glu  Leu Ala Ser Gln Arg  Lys Ser Arg 
    1370                 1375                 1380             


Gly Glu  Lys Asn Pro Pro Val  Tyr Ser Ser Arg Val  Lys Ile Ser 
    1385                 1390                 1395             


Met Pro  Ser Cys Gln Asp Gln  Asp Asp Met Ala Glu  Lys Ser Gly 
    1400                 1405                 1410             


Ser Glu  Thr Pro Asp Gly Pro  Leu Ser Pro Gly Lys  Met Glu Asp 
    1415                 1420                 1425             


Ile Ser  Pro Val Gln Thr Asp  Ala Leu Asp Ser Val  Arg Glu Arg 
    1430                 1435                 1440             


Leu His  Gly Gly Lys Gly Leu  Pro Phe Tyr Ala Gly  Leu Ser Pro 
    1445                 1450                 1455             


Ala Gly  Lys Leu Val Ala Tyr  Lys Arg Lys Pro Ser  Ser Ser Thr 
    1460                 1465                 1470             


Ser Gly  Leu Ile Gln Val Ala  Ser Asn Ala Lys Val  Ala Ala Ser 
    1475                 1480                 1485             


Arg Lys  Pro Arg Thr Leu Leu  Pro Ser Thr Ser Asn  Ser Lys Met 
    1490                 1495                 1500             


Ala Ser  Ser Ser Gly Thr Ala  Thr Asn Arg Pro Gly  Lys Asn Leu 
    1505                 1510                 1515             


Lys Ala  Phe Val Pro Ala Lys  Arg Pro Ile Ala Ala  Arg Pro Ser 
    1520                 1525                 1530             


Pro Gly  Gly Val Phe Thr Gln  Phe Val Met Ser Lys  Val Gly Ala 
    1535                 1540                 1545             


Leu Gln  Gln Lys Ile Pro Gly  Val Ser Thr Pro Gln  Thr Leu Ala 
    1550                 1555                 1560             


Gly Thr  Gln Lys Phe Ser Ile  Arg Pro Ser Pro Val  Met Val Val 
    1565                 1570                 1575             


Thr Pro  Val Val Ser Ser Glu  Pro Val Gln Val Cys  Ser Pro Val 
    1580                 1585                 1590             


Thr Ala  Ala Val Thr Thr Thr  Thr Pro Gln Val Phe  Leu Glu Asn 
    1595                 1600                 1605             


Thr Thr  Ala Val Thr Pro Met  Thr Ala Ile Ser Asp  Val Glu Thr 
    1610                 1615                 1620             


Lys Glu  Thr Thr Tyr Ser Ser  Gly Ala Thr Thr Thr  Gly Val Val 
    1625                 1630                 1635             


Glu Val  Ser Glu Thr Asn Thr  Ser Thr Ser Val Thr  Ser Thr Gln 
    1640                 1645                 1650             


Ser Thr  Ala Thr Val Asn Leu  Thr Lys Thr Thr Gly  Ile Thr Thr 
    1655                 1660                 1665             


Pro Val  Ala Ser Val Ala Phe  Pro Lys Ser Leu Val  Ala Ser Pro 
    1670                 1675                 1680             


Ser Thr  Ile Thr Leu Pro Val  Ala Ser Thr Ala Ser  Thr Ser Leu 
    1685                 1690                 1695             


Val Val  Val Thr Ala Ala Ala  Ser Ser Ser Met Val  Thr Thr Pro 
    1700                 1705                 1710             


Thr Ser  Ser Leu Gly Ser Val  Pro Ile Ile Leu Ser  Gly Ile Asn 
    1715                 1720                 1725             


Gly Ser  Pro Pro Val Ser Gln  Arg Pro Glu Asn Ala  Ala Gln Ile 
    1730                 1735                 1740             


Pro Val  Ala Thr Pro Gln Val  Ser Pro Asn Thr Val  Lys Arg Ala 
    1745                 1750                 1755             


Gly Pro  Arg Leu Leu Leu Ile  Pro Val Gln Gln Gly  Ser Pro Thr 
    1760                 1765                 1770             


Leu Arg  Pro Val Ser Asn Thr  Gln Leu Gln Gly His  Arg Met Val 
    1775                 1780                 1785             


Leu Gln  Pro Val Arg Ser Pro  Ser Gly Met Asn Leu  Phe Arg His 
    1790                 1795                 1800             


Pro Asn  Gly Gln Ile Val Gln  Leu Leu Pro Leu His  Gln Leu Arg 
    1805                 1810                 1815             


Gly Ser  Asn Thr Gln Pro Asn  Leu Gln Pro Val Met  Phe Arg Asn 
    1820                 1825                 1830             


Pro Gly  Ser Val Met Gly Ile  Arg Leu Pro Ala Pro  Ser Lys Pro 
    1835                 1840                 1845             


Ser Glu  Thr Pro Pro Ser Ser  Thr Ser Ser Ser Ala  Phe Ser Val 
    1850                 1855                 1860             


Met Asn  Pro Val Ile Gln Ala  Val Gly Ser Ser Ser  Ala Val Asn 
    1865                 1870                 1875             


Val Ile  Thr Gln Ala Pro Ser  Leu Leu Ser Ser Gly  Ala Ser Phe 
    1880                 1885                 1890             


Val Ser  Gln Ala Gly Thr Leu  Thr Leu Arg Ile Ser  Pro Pro Glu 
    1895                 1900                 1905             


Pro Gln  Ser Phe Ala Ser Lys  Thr Gly Ser Glu Thr  Lys Ile Thr 
    1910                 1915                 1920             


Tyr Ser  Ser Gly Gly Gln Pro  Val Gly Thr Ala Ser  Leu Ile Pro 
    1925                 1930                 1935             


Leu Gln  Ser Gly Ser Phe Ala  Leu Leu Gln Leu Pro  Gly Gln Lys 
    1940                 1945                 1950             


Pro Val  Pro Ser Ser Ile Leu  Gln His Val Ala Ser  Leu Gln Met 
    1955                 1960                 1965             


Lys Arg  Glu Ser Gln Asn Pro  Asp Gln Lys Asp Glu  Thr Asn Ser 
    1970                 1975                 1980             


Ile Lys  Arg Glu Gln Glu Thr  Lys Lys Val Leu Gln  Ser Glu Gly 
    1985                 1990                 1995             


Glu Ala  Val Asp Pro Glu Ala  Asn Val Ile Lys Gln  Asn Ser Gly 
    2000                 2005                 2010             


Ala Ala  Thr Ser Glu Glu Thr  Leu Asn Asp Ser Leu  Glu Asp Arg 
    2015                 2020                 2025             


Gly Asp  His Leu Asp Glu Glu  Cys Leu Pro Glu Glu  Gly Cys Ala 
    2030                 2035                 2040             


Thr Val  Lys Pro Ser Glu His  Ser Cys Ile Thr Gly  Ser His Thr 
    2045                 2050                 2055             


Asp Gln  Asp Tyr Lys Asp Val  Asn Glu Glu Tyr Gly  Ala Arg Asn 
    2060                 2065                 2070             


Arg Lys  Ser Ser Lys Glu Lys  Val Ala Val Leu Glu  Val Arg Thr 
    2075                 2080                 2085             


Ile Ser  Glu Lys Ala Ser Asn  Lys Thr Val Gln Asn  Leu Ser Lys 
    2090                 2095                 2100             


Val Gln  His Gln Lys Leu Gly  Asp Val Lys Val Glu  Gln Gln Lys 
    2105                 2110                 2115             


Gly Phe  Asp Asn Pro Glu Glu  Asn Ser Ser Glu Phe  Pro Val Thr 
    2120                 2125                 2130             


Phe Lys  Glu Glu Ser Lys Phe  Glu Leu Ser Gly Ser  Lys Val Met 
    2135                 2140                 2145             


Glu Gln  Gln Ser Asn Leu Gln  Pro Glu Ala Lys Glu  Lys Glu Cys 
    2150                 2155                 2160             


Gly Asp  Ser Leu Glu Lys Asp  Arg Glu Arg Trp Arg  Lys His Leu 
    2165                 2170                 2175             


Lys Gly  Pro Leu Thr Arg Lys  Cys Val Gly Ala Ser  Gln Glu Cys 
    2180                 2185                 2190             


Lys Lys  Glu Ala Asp Glu Gln  Leu Ile Lys Glu Thr  Lys Thr Cys 
    2195                 2200                 2205             


Gln Glu  Asn Ser Asp Val Phe  Gln Gln Glu Gln Gly  Ile Ser Asp 
    2210                 2215                 2220             


Leu Leu  Gly Lys Ser Gly Ile  Thr Glu Asp Ala Arg  Val Leu Lys 
    2225                 2230                 2235             


Thr Glu  Cys Asp Ser Trp Ser  Arg Ile Ser Asn Pro  Ser Ala Phe 
    2240                 2245                 2250             


Ser Ile  Val Pro Arg Arg Ala  Ala Lys Ser Ser Arg  Gly Asn Gly 
    2255                 2260                 2265             


His Phe  Gln Gly His Leu Leu  Leu Pro Gly Glu Gln  Ile Gln Pro 
    2270                 2275                 2280             


Lys Gln  Glu Lys Lys Gly Gly  Arg Ser Ser Ala Asp  Phe Thr Val 
    2285                 2290                 2295             


Leu Asp  Leu Glu Glu Asp Asp  Glu Asp Asp Asn Glu  Lys Thr Asp 
    2300                 2305                 2310             


Asp Ser  Ile Asp Glu Ile Val  Asp Val Val Ser Asp  Tyr Gln Ser 
    2315                 2320                 2325             


Glu Glu  Val Asp Asp Val Glu  Lys Asn Asn Cys Val  Glu Tyr Ile 
    2330                 2335                 2340             


Glu Asp  Asp Glu Glu His Val  Asp Ile Glu Thr Val  Glu Glu Leu 
    2345                 2350                 2355             


Ser Glu  Glu Ile Asn Val Ala  His Leu Lys Thr Thr  Ala Ala His 
    2360                 2365                 2370             


Thr Gln  Ser Phe Lys Gln Pro  Ser Cys Thr His Ile  Ser Ala Asp 
    2375                 2380                 2385             


Glu Lys  Ala Ala Glu Arg Ser  Arg Lys Ala Pro Pro  Ile Pro Leu 
    2390                 2395                 2400             


Lys Leu  Lys Pro Asp Tyr Trp  Ser Asp Lys Leu Gln  Lys Glu Ala 
    2405                 2410                 2415             


Glu Ala  Phe Ala Tyr Tyr Arg  Arg Thr His Thr Ala  Asn Glu Arg 
    2420                 2425                 2430             


Arg Arg  Arg Gly Glu Met Arg  Asp Leu Phe Glu Lys  Leu Lys Ile 
    2435                 2440                 2445             


Thr Leu  Gly Leu Leu His Ser  Ser Lys Val Ser Lys  Ser Leu Ile 
    2450                 2455                 2460             


Leu Thr  Arg Ala Phe Ser Glu  Ile Gln Gly Leu Thr  Asp Gln Ala 
    2465                 2470                 2475             


Asp Lys  Leu Ile Gly Gln Lys  Asn Leu Leu Thr Arg  Lys Arg Asn 
    2480                 2485                 2490             


Ile Leu  Ile Arg Lys Val Ser  Ser Leu Ser Gly Lys  Thr Glu Glu 
    2495                 2500                 2505             


Val Val  Leu Lys Lys Leu Glu  Tyr Ile Tyr Ala Lys  Gln Gln Ala 
    2510                 2515                 2520             


Leu Glu  Ala Gln Lys Arg Lys  Lys Lys Met Gly Ser  Asp Glu Phe 
    2525                 2530                 2535             


Asp Ile  Ser Pro Arg Ile Ser  Lys Gln Gln Glu Gly  Ser Ser Ala 
    2540                 2545                 2550             


Ser Ser  Val Asp Leu Gly Gln  Met Phe Ile Asn Asn  Arg Arg Gly 
    2555                 2560                 2565             


Lys Pro  Leu Ile Leu Ser Arg  Lys Lys Asp Gln Ala  Thr Glu Asn 
    2570                 2575                 2580             


Thr Ser  Pro Leu Asn Thr Pro  His Thr Ser Ala Asn  Leu Val Met 
    2585                 2590                 2595             


Thr Pro  Gln Gly Gln Leu Leu  Thr Leu Lys Gly Pro  Leu Phe Ser 
    2600                 2605                 2610             


Gly Pro  Val Val Ala Val Ser  Pro Asp Leu Leu Glu  Ser Asp Leu 
    2615                 2620                 2625             


Lys Pro  Gln Val Ala Gly Ser  Ala Val Ala Leu Pro  Glu Asn Asp 
    2630                 2635                 2640             


Asp Leu  Phe Met Met Pro Arg  Ile Val Asn Val Thr  Ser Leu Ala 
    2645                 2650                 2655             


Thr Glu  Gly Gly Leu Val Asp  Met Gly Gly Ser Lys  Tyr Pro His 
    2660                 2665                 2670             


Glu Val  Pro Asp Ser Lys Pro  Ser Asp His Leu Lys  Asp Thr Val 
    2675                 2680                 2685             


Arg Asn  Glu Asp Asn Ser Leu  Glu Asp Lys Gly Arg  Ile Ser Ser 
    2690                 2695                 2700             


Arg Gly  Asn Arg Asp Gly Arg  Val Thr Leu Gly Pro  Thr Gln Val 
    2705                 2710                 2715             


Phe Leu  Ala Asn Lys Asp Ser  Gly Tyr Pro Gln Ile  Val Asp Val 
    2720                 2725                 2730             


Ser Asn  Met Gln Lys Ala Gln  Glu Phe Leu Pro Lys  Lys Ile Ser 
    2735                 2740                 2745             


Gly Asp  Met Arg Gly Ile Gln  Tyr Lys Trp Lys Glu  Ser Glu Ser 
    2750                 2755                 2760             


Arg Gly  Glu Arg Val Lys Ser  Lys Asp Ser Ser Phe  His Lys Leu 
    2765                 2770                 2775             


Lys Met  Lys Asp Leu Lys Asp  Ser Ser Ile Glu Met  Glu Leu Arg 
    2780                 2785                 2790             


Lys Val  Thr Ser Ala Ile Glu  Glu Ala Ala Leu Asp  Ser Ser Glu 
    2795                 2800                 2805             


Leu Leu  Thr Asn Met Glu Asp  Glu Asp Asp Thr Asp  Glu Thr Leu 
    2810                 2815                 2820             


Thr Ser  Leu Leu Asn Glu Ile  Ala Phe Leu Asn Gln  Gln Leu Asn 
    2825                 2830                 2835             


Asp Asp  Ser Val Gly Leu Ala  Glu Leu Pro Ser Ser  Met Asp Thr 
    2840                 2845                 2850             


Glu Phe  Pro Gly Asp Ala Arg  Arg Ala Phe Ile Ser  Lys Val Pro 
    2855                 2860                 2865             


Pro Gly  Ser Arg Ala Thr Phe  Gln Val Glu His Leu  Gly Thr Gly 
    2870                 2875                 2880             


Leu Lys  Glu Leu Pro Asp Val  Gln Gly Glu Ser Asp  Ser Ile Ser 
    2885                 2890                 2895             


Pro Leu  Leu Leu His Leu Glu  Asp Asp Asp Phe Ser  Glu Asn Glu 
    2900                 2905                 2910             


Lys Gln  Leu Ala Glu Pro Ala  Ser Glu Pro Asp Val  Leu Lys Ile 
    2915                 2920                 2925             


Val Ile  Asp Ser Glu Ile Lys  Asp Ser Leu Leu Ser  Asn Lys Lys 
    2930                 2935                 2940             


Ala Ile  Asp Gly Gly Lys Asn  Thr Ser Gly Leu Pro  Ala Glu Pro 
    2945                 2950                 2955             


Glu Ser  Val Ser Ser Pro Pro  Thr Leu His Met Lys  Thr Gly Leu 
    2960                 2965                 2970             


Glu Asn  Ser Asn Ser Thr Asp  Thr Leu Trp Arg Pro  Met Pro Lys 
    2975                 2980                 2985             


Leu Ala  Pro Leu Gly Leu Lys  Val Ala Asn Pro Ser  Ser Asp Ala 
    2990                 2995                 3000             


Asp Gly  Gln Ser Leu Lys Val  Met Pro Cys Leu Ala  Pro Ile Ala 
    3005                 3010                 3015             


Ala Lys  Val Gly Ser Val Gly  His Lys Met Asn Leu  Thr Gly Asn 
    3020                 3025                 3030             


Asp Gln  Glu Gly Arg Glu Ser  Lys Val Met Pro Thr  Leu Ala Pro 
    3035                 3040                 3045             


Val Val  Ala Lys Leu Gly Asn  Ser Gly Ala Ser Pro  Ser Ser Ala 
    3050                 3055                 3060             


Gly Lys  
    3065 


<210>  50
<211>  1138
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Glu Glu Lys Gln Gln Ile Ile Leu Ala Asn Gln Asp Gly Gly Thr 
1               5                   10                  15      


Val Ala Gly Ala Ala Pro Thr Phe Phe Val Ile Leu Lys Gln Pro Gly 
            20                  25                  30          


Asn Gly Lys Thr Asp Gln Gly Ile Leu Val Thr Asn Gln Asp Ala Cys 
        35                  40                  45              


Ala Leu Ala Ser Ser Val Ser Ser Pro Val Lys Ser Lys Gly Lys Ile 
    50                  55                  60                  


Cys Leu Pro Ala Asp Cys Thr Val Gly Gly Ile Thr Val Thr Leu Asp 
65                  70                  75                  80  


Asn Asn Ser Met Trp Asn Glu Phe Tyr His Arg Ser Thr Glu Met Ile 
                85                  90                  95      


Leu Thr Lys Gln Gly Arg Arg Met Phe Pro Tyr Cys Arg Tyr Trp Ile 
            100                 105                 110         


Thr Gly Leu Asp Ser Asn Leu Lys Tyr Ile Leu Val Met Asp Ile Ser 
        115                 120                 125             


Pro Val Asp Asn His Arg Tyr Lys Trp Asn Gly Arg Trp Trp Glu Pro 
    130                 135                 140                 


Ser Gly Lys Ala Glu Pro His Val Leu Gly Arg Val Phe Ile His Pro 
145                 150                 155                 160 


Glu Ser Pro Ser Thr Gly His Tyr Trp Met His Gln Pro Val Ser Phe 
                165                 170                 175     


Tyr Lys Leu Lys Leu Thr Asn Asn Thr Leu Asp Gln Glu Gly His Ile 
            180                 185                 190         


Ile Leu His Ser Met His Arg Tyr Leu Pro Arg Leu His Leu Val Pro 
        195                 200                 205             


Ala Glu Lys Ala Val Glu Val Ile Gln Leu Asn Gly Pro Gly Val His 
    210                 215                 220                 


Thr Phe Thr Phe Pro Gln Thr Glu Phe Phe Ala Val Thr Ala Tyr Gln 
225                 230                 235                 240 


Asn Ile Gln Ile Thr Gln Leu Lys Ile Asp Tyr Asn Pro Phe Ala Lys 
                245                 250                 255     


Gly Phe Arg Asp Asp Gly Leu Asn Asn Lys Pro Gln Arg Asp Gly Lys 
            260                 265                 270         


Gln Lys Asn Ser Ser Asp Gln Glu Gly Asn Asn Ile Ser Ser Ser Ser 
        275                 280                 285             


Gly His Arg Val Arg Leu Thr Glu Gly Gln Gly Ser Glu Ile Gln Pro 
    290                 295                 300                 


Gly Asp Leu Asp Pro Leu Ser Arg Gly His Glu Thr Ser Gly Lys Gly 
305                 310                 315                 320 


Leu Glu Lys Thr Ser Leu Asn Ile Lys Arg Asp Phe Leu Gly Phe Met 
                325                 330                 335     


Asp Thr Asp Ser Ala Leu Ser Glu Val Pro Gln Leu Lys Gln Glu Ile 
            340                 345                 350         


Ser Glu Cys Leu Ile Ala Ser Ser Phe Glu Asp Asp Ser Arg Val Ala 
        355                 360                 365             


Ser Pro Leu Asp Gln Asn Gly Ser Phe Asn Val Val Ile Lys Glu Glu 
    370                 375                 380                 


Pro Leu Asp Asp Tyr Asp Tyr Glu Leu Gly Glu Cys Pro Glu Gly Val 
385                 390                 395                 400 


Thr Val Lys Gln Glu Glu Thr Asp Glu Glu Thr Asp Val Tyr Ser Asn 
                405                 410                 415     


Ser Asp Asp Asp Pro Ile Leu Glu Lys Gln Leu Lys Arg His Asn Lys 
            420                 425                 430         


Val Asp Asn Pro Glu Ala Asp His Leu Ser Ser Lys Trp Leu Pro Ser 
        435                 440                 445             


Ser Pro Ser Gly Val Ala Lys Ala Lys Met Phe Lys Leu Asp Thr Gly 
    450                 455                 460                 


Lys Met Pro Val Val Tyr Leu Glu Pro Cys Ala Val Thr Arg Ser Thr 
465                 470                 475                 480 


Val Lys Ile Ser Glu Leu Pro Asp Asn Met Leu Ser Thr Ser Arg Lys 
                485                 490                 495     


Asp Lys Ser Ser Met Leu Ala Glu Leu Glu Tyr Leu Pro Thr Tyr Ile 
            500                 505                 510         


Glu Asn Ser Asn Glu Thr Ala Phe Cys Leu Gly Lys Glu Ser Glu Asn 
        515                 520                 525             


Gly Leu Arg Lys His Ser Pro Asp Leu Arg Val Val Gln Lys Tyr Pro 
    530                 535                 540                 


Leu Leu Lys Glu Pro Gln Trp Lys Tyr Pro Asp Ile Ser Asp Ser Ile 
545                 550                 555                 560 


Ser Thr Glu Arg Ile Leu Asp Asp Ser Lys Asp Ser Val Gly Asp Ser 
                565                 570                 575     


Leu Ser Gly Lys Glu Asp Leu Gly Arg Lys Arg Thr Thr Met Leu Lys 
            580                 585                 590         


Ile Ala Thr Ala Ala Lys Val Val Asn Ala Asn Gln Asn Ala Ser Pro 
        595                 600                 605             


Asn Val Pro Gly Lys Arg Gly Arg Pro Arg Lys Leu Lys Leu Cys Lys 
    610                 615                 620                 


Ala Gly Arg Pro Pro Lys Asn Thr Gly Lys Ser Leu Ile Ser Thr Lys 
625                 630                 635                 640 


Asn Thr Pro Val Ser Pro Gly Ser Thr Phe Pro Asp Val Lys Pro Asp 
                645                 650                 655     


Leu Glu Asp Val Asp Gly Val Leu Phe Val Ser Phe Glu Ser Lys Glu 
            660                 665                 670         


Ala Leu Asp Ile His Ala Val Asp Gly Thr Thr Glu Glu Ser Ser Ser 
        675                 680                 685             


Leu Gln Ala Ser Thr Thr Asn Asp Ser Gly Tyr Arg Ala Arg Ile Ser 
    690                 695                 700                 


Gln Leu Glu Lys Glu Leu Ile Glu Asp Leu Lys Thr Leu Arg His Lys 
705                 710                 715                 720 


Gln Val Ile His Pro Gly Leu Gln Glu Val Gly Leu Lys Leu Asn Ser 
                725                 730                 735     


Val Asp Pro Thr Met Ser Ile Asp Leu Lys Tyr Leu Gly Val Gln Leu 
            740                 745                 750         


Pro Leu Ala Pro Ala Thr Ser Phe Pro Phe Trp Asn Leu Thr Gly Thr 
        755                 760                 765             


Asn Pro Ala Ser Pro Asp Ala Gly Phe Pro Phe Val Ser Arg Thr Gly 
    770                 775                 780                 


Lys Thr Asn Asp Phe Thr Lys Ile Lys Gly Trp Arg Gly Lys Phe His 
785                 790                 795                 800 


Ser Ala Ser Ala Ser Arg Asn Glu Gly Gly Asn Ser Glu Ser Ser Leu 
                805                 810                 815     


Lys Asn Arg Ser Ala Phe Cys Ser Asp Lys Leu Asp Glu Tyr Leu Glu 
            820                 825                 830         


Asn Glu Gly Lys Leu Met Glu Thr Ser Met Gly Phe Ser Ser Asn Ala 
        835                 840                 845             


Pro Thr Ser Pro Val Val Tyr Gln Leu Pro Thr Lys Ser Thr Ser Tyr 
    850                 855                 860                 


Val Arg Thr Leu Asp Ser Val Leu Lys Lys Gln Ser Thr Ile Ser Pro 
865                 870                 875                 880 


Ser Thr Ser Tyr Ser Leu Lys Pro His Ser Val Pro Pro Val Ser Arg 
                885                 890                 895     


Lys Ala Lys Ser Gln Asn Arg Gln Ala Thr Phe Ser Gly Arg Thr Lys 
            900                 905                 910         


Ser Ser Tyr Lys Ser Ile Leu Pro Tyr Pro Val Ser Pro Lys Gln Lys 
        915                 920                 925             


Tyr Ser His Val Ile Leu Gly Asp Lys Val Thr Lys Asn Ser Ser Gly 
    930                 935                 940                 


Ile Ile Ser Glu Asn Gln Ala Asn Asn Phe Val Val Pro Thr Leu Asp 
945                 950                 955                 960 


Glu Asn Ile Phe Pro Lys Gln Ile Ser Leu Arg Gln Ala Gln Gln Gln 
                965                 970                 975     


Gln Gln Gln Gln Gln Gly Ser Arg Pro Pro Gly Leu Ser Lys Ser Gln 
            980                 985                 990         


Val Lys Leu Met Asp Leu Glu Asp  Cys Ala Leu Trp Glu  Gly Lys Pro 
        995                 1000                 1005             


Arg Thr  Tyr Ile Thr Glu Glu  Arg Ala Asp Val Ser  Leu Thr Thr 
    1010                 1015                 1020             


Leu Leu  Thr Ala Gln Ala Ser  Leu Lys Thr Lys Pro  Ile His Thr 
    1025                 1030                 1035             


Ile Ile  Arg Lys Arg Ala Pro  Pro Cys Asn Asn Asp  Phe Cys Arg 
    1040                 1045                 1050             


Leu Gly  Cys Val Cys Ser Ser  Leu Ala Leu Glu Lys  Arg Gln Pro 
    1055                 1060                 1065             


Ala His  Cys Arg Arg Pro Asp  Cys Met Phe Gly Cys  Thr Cys Leu 
    1070                 1075                 1080             


Lys Arg  Lys Val Val Leu Val  Lys Gly Gly Ser Lys  Thr Lys His 
    1085                 1090                 1095             


Phe Gln  Arg Lys Ala Ala His  Arg Asp Pro Val Phe  Tyr Asp Thr 
    1100                 1105                 1110             


Leu Gly  Glu Glu Ala Arg Glu  Glu Glu Glu Gly Ile  Arg Glu Glu 
    1115                 1120                 1125             


Glu Glu  Gln Leu Lys Glu Lys  Lys Lys Arg 
    1130                 1135             


<210>  51
<211>  2856
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Glu Glu Lys Gln Gln Ile Ile Leu Ala Asn Gln Asp Gly Gly Thr 
1               5                   10                  15      


Val Ala Gly Ala Ala Pro Thr Phe Phe Val Ile Leu Lys Gln Pro Gly 
            20                  25                  30          


Asn Gly Lys Thr Asp Gln Gly Ile Leu Val Thr Asn Gln Asp Ala Cys 
        35                  40                  45              


Ala Leu Ala Ser Ser Val Ser Ser Pro Val Lys Ser Lys Gly Lys Ile 
    50                  55                  60                  


Cys Leu Pro Ala Asp Cys Thr Val Gly Gly Ile Thr Val Thr Leu Asp 
65                  70                  75                  80  


Asn Asn Ser Met Trp Asn Glu Phe Tyr His Arg Ser Thr Glu Met Ile 
                85                  90                  95      


Leu Thr Lys Gln Gly Arg Arg Met Phe Pro Tyr Cys Arg Tyr Trp Ile 
            100                 105                 110         


Thr Gly Leu Asp Ser Asn Leu Lys Tyr Ile Leu Val Met Asp Ile Ser 
        115                 120                 125             


Pro Val Asp Asn His Arg Tyr Lys Trp Asn Gly Arg Trp Trp Glu Pro 
    130                 135                 140                 


Ser Gly Lys Ala Glu Pro His Val Leu Gly Arg Val Phe Ile His Pro 
145                 150                 155                 160 


Glu Ser Pro Ser Thr Gly His Tyr Trp Met His Gln Pro Val Ser Phe 
                165                 170                 175     


Tyr Lys Leu Lys Leu Thr Asn Asn Thr Leu Asp Gln Glu Gly His Ile 
            180                 185                 190         


Ile Leu His Ser Met His Arg Tyr Leu Pro Arg Leu His Leu Val Pro 
        195                 200                 205             


Ala Glu Lys Ala Val Glu Val Ile Gln Leu Asn Gly Pro Gly Val His 
    210                 215                 220                 


Thr Phe Thr Phe Pro Gln Thr Glu Phe Phe Ala Val Thr Ala Tyr Gln 
225                 230                 235                 240 


Asn Ile Gln Ile Thr Gln Leu Lys Ile Asp Tyr Asn Pro Phe Ala Lys 
                245                 250                 255     


Gly Phe Arg Asp Asp Gly Leu Asn Asn Lys Pro Gln Arg Asp Gly Lys 
            260                 265                 270         


Gln Lys Asn Ser Ser Asp Gln Glu Gly Asn Asn Ile Ser Ser Ser Ser 
        275                 280                 285             


Gly His Arg Val Arg Leu Thr Glu Gly Gln Gly Ser Glu Ile Gln Pro 
    290                 295                 300                 


Gly Asp Leu Asp Pro Leu Ser Arg Gly His Glu Thr Ser Gly Lys Gly 
305                 310                 315                 320 


Leu Glu Lys Thr Ser Leu Asn Ile Lys Arg Asp Phe Leu Gly Phe Met 
                325                 330                 335     


Asp Thr Asp Ser Ala Leu Ser Glu Val Pro Gln Leu Lys Gln Glu Ile 
            340                 345                 350         


Ser Glu Cys Leu Ile Ala Ser Ser Phe Glu Asp Asp Ser Arg Val Ala 
        355                 360                 365             


Ser Pro Leu Asp Gln Asn Gly Ser Phe Asn Val Val Ile Lys Glu Glu 
    370                 375                 380                 


Pro Leu Asp Asp Tyr Asp Tyr Glu Leu Gly Glu Cys Pro Glu Gly Val 
385                 390                 395                 400 


Thr Val Lys Gln Glu Glu Thr Asp Glu Glu Thr Asp Val Tyr Ser Asn 
                405                 410                 415     


Ser Asp Asp Asp Pro Ile Leu Glu Lys Gln Leu Lys Arg His Asn Lys 
            420                 425                 430         


Val Asp Asn Pro Glu Ala Asp His Leu Ser Ser Lys Trp Leu Pro Ser 
        435                 440                 445             


Ser Pro Ser Gly Val Ala Lys Ala Lys Met Phe Lys Leu Asp Thr Gly 
    450                 455                 460                 


Lys Met Pro Val Val Tyr Leu Glu Pro Cys Ala Val Thr Arg Ser Thr 
465                 470                 475                 480 


Val Lys Ile Ser Glu Leu Pro Asp Asn Met Leu Ser Thr Ser Arg Lys 
                485                 490                 495     


Asp Lys Ser Ser Met Leu Ala Glu Leu Glu Tyr Leu Pro Thr Tyr Ile 
            500                 505                 510         


Glu Asn Ser Asn Glu Thr Ala Phe Cys Leu Gly Lys Glu Ser Glu Asn 
        515                 520                 525             


Gly Leu Arg Lys His Ser Pro Asp Leu Arg Val Val Gln Lys Tyr Pro 
    530                 535                 540                 


Leu Leu Lys Glu Pro Gln Trp Lys Tyr Pro Asp Ile Ser Asp Ser Ile 
545                 550                 555                 560 


Ser Thr Glu Arg Ile Leu Asp Asp Ser Lys Asp Ser Val Gly Asp Ser 
                565                 570                 575     


Leu Ser Gly Lys Glu Asp Leu Gly Arg Lys Arg Thr Thr Met Leu Lys 
            580                 585                 590         


Ile Ala Thr Ala Ala Lys Val Val Asn Ala Asn Gln Asn Ala Ser Pro 
        595                 600                 605             


Asn Val Pro Gly Lys Arg Gly Arg Pro Arg Lys Leu Lys Leu Cys Lys 
    610                 615                 620                 


Ala Gly Arg Pro Pro Lys Asn Thr Gly Lys Ser Leu Ile Ser Thr Lys 
625                 630                 635                 640 


Asn Thr Pro Val Ser Pro Gly Ser Thr Phe Pro Asp Val Lys Pro Asp 
                645                 650                 655     


Leu Glu Asp Val Asp Gly Val Leu Phe Val Ser Phe Glu Ser Lys Glu 
            660                 665                 670         


Ala Leu Asp Ile His Ala Val Asp Gly Thr Thr Glu Glu Ser Ser Ser 
        675                 680                 685             


Leu Gln Ala Ser Thr Thr Asn Asp Ser Gly Tyr Arg Ala Arg Ile Ser 
    690                 695                 700                 


Gln Leu Glu Lys Glu Leu Ile Glu Asp Leu Lys Thr Leu Arg His Lys 
705                 710                 715                 720 


Gln Val Ile His Pro Gly Leu Gln Glu Val Gly Leu Lys Leu Asn Ser 
                725                 730                 735     


Val Asp Pro Thr Met Ser Ile Asp Leu Lys Tyr Leu Gly Val Gln Leu 
            740                 745                 750         


Pro Leu Ala Pro Ala Thr Ser Phe Pro Phe Trp Asn Leu Thr Gly Thr 
        755                 760                 765             


Asn Pro Ala Ser Pro Asp Ala Gly Phe Pro Phe Val Ser Arg Thr Gly 
    770                 775                 780                 


Lys Thr Asn Asp Phe Thr Lys Ile Lys Gly Trp Arg Gly Lys Phe His 
785                 790                 795                 800 


Ser Ala Ser Ala Ser Arg Asn Glu Gly Gly Asn Ser Glu Ser Ser Leu 
                805                 810                 815     


Lys Asn Arg Ser Ala Phe Cys Ser Asp Lys Leu Asp Glu Tyr Leu Glu 
            820                 825                 830         


Asn Glu Gly Lys Leu Met Glu Thr Ser Met Gly Phe Ser Ser Asn Ala 
        835                 840                 845             


Pro Thr Ser Pro Val Val Tyr Gln Leu Pro Thr Lys Ser Thr Ser Tyr 
    850                 855                 860                 


Val Arg Thr Leu Asp Ser Val Leu Lys Lys Gln Ser Thr Ile Ser Pro 
865                 870                 875                 880 


Ser Thr Ser Tyr Ser Leu Lys Pro His Ser Val Pro Pro Val Ser Arg 
                885                 890                 895     


Lys Ala Lys Ser Gln Asn Arg Gln Ala Thr Phe Ser Gly Arg Thr Lys 
            900                 905                 910         


Ser Ser Tyr Lys Ser Ile Leu Pro Tyr Pro Val Ser Pro Lys Gln Lys 
        915                 920                 925             


Tyr Ser His Val Ile Leu Gly Asp Lys Val Thr Lys Asn Ser Ser Gly 
    930                 935                 940                 


Ile Ile Ser Glu Asn Gln Ala Asn Asn Phe Val Val Pro Thr Leu Asp 
945                 950                 955                 960 


Glu Asn Ile Phe Pro Lys Gln Ile Ser Leu Arg Gln Ala Gln Gln Gln 
                965                 970                 975     


Gln Gln Gln Gln Gln Gly Ser Arg Pro Pro Gly Leu Ser Lys Ser Gln 
            980                 985                 990         


Val Lys Leu Met Asp Leu Glu Asp  Cys Ala Leu Trp Glu  Gly Lys Pro 
        995                 1000                 1005             


Arg Thr  Tyr Ile Thr Glu Glu  Arg Ala Asp Val Ser  Leu Thr Thr 
    1010                 1015                 1020             


Leu Leu  Thr Ala Gln Ala Ser  Leu Lys Thr Lys Pro  Ile His Thr 
    1025                 1030                 1035             


Ile Ile  Arg Lys Arg Ala Pro  Pro Cys Asn Asn Asp  Phe Cys Arg 
    1040                 1045                 1050             


Leu Gly  Cys Val Cys Ser Ser  Leu Ala Leu Glu Lys  Arg Gln Pro 
    1055                 1060                 1065             


Ala His  Cys Arg Arg Pro Asp  Cys Met Phe Gly Cys  Thr Cys Leu 
    1070                 1075                 1080             


Lys Arg  Lys Val Val Leu Val  Lys Gly Gly Ser Lys  Thr Lys His 
    1085                 1090                 1095             


Phe Gln  Arg Lys Ala Ala His  Arg Asp Pro Val Phe  Tyr Asp Thr 
    1100                 1105                 1110             


Leu Gly  Glu Glu Ala Arg Glu  Glu Glu Glu Gly Ile  Arg Glu Glu 
    1115                 1120                 1125             


Glu Glu  Gln Leu Lys Glu Lys  Lys Lys Arg Lys Lys  Leu Glu Tyr 
    1130                 1135                 1140             


Thr Ile  Cys Glu Thr Glu Pro  Glu Gln Pro Val Arg  His Tyr Pro 
    1145                 1150                 1155             


Leu Trp  Val Lys Val Glu Gly  Glu Val Asp Pro Glu  Pro Val Tyr 
    1160                 1165                 1170             


Ile Pro  Thr Pro Ser Val Ile  Glu Pro Met Lys Pro  Leu Leu Leu 
    1175                 1180                 1185             


Pro Gln  Pro Glu Val Leu Ser  Pro Thr Val Lys Gly  Lys Leu Leu 
    1190                 1195                 1200             


Thr Gly  Ile Lys Ser Pro Arg  Ser Tyr Thr Pro Lys  Pro Asn Pro 
    1205                 1210                 1215             


Val Ile  Arg Glu Glu Asp Lys  Asp Pro Val Tyr Leu  Tyr Phe Glu 
    1220                 1225                 1230             


Ser Met  Met Thr Cys Ala Arg  Val Arg Val Tyr Glu  Arg Lys Lys 
    1235                 1240                 1245             


Glu Asp  Gln Arg Gln Pro Ser  Ser Ser Ser Ser Pro  Ser Pro Ser 
    1250                 1255                 1260             


Phe Gln  Gln Gln Thr Ser Cys  His Ser Ser Pro Glu  Asn His Asn 
    1265                 1270                 1275             


Asn Ala  Lys Glu Pro Asp Ser  Glu Gln Gln Pro Leu  Lys Gln Leu 
    1280                 1285                 1290             


Thr Cys  Asp Leu Glu Asp Asp  Ser Asp Lys Leu Gln  Glu Lys Ser 
    1295                 1300                 1305             


Trp Lys  Ser Ser Cys Asn Glu  Gly Glu Ser Ser Ser  Thr Ser Tyr 
    1310                 1315                 1320             


Met His  Gln Arg Ser Pro Gly  Gly Pro Thr Lys Leu  Ile Glu Ile 
    1325                 1330                 1335             


Ile Ser  Asp Cys Asn Trp Glu  Glu Asp Arg Asn Lys  Ile Leu Ser 
    1340                 1345                 1350             


Ile Leu  Ser Gln His Ile Asn  Ser Asn Met Pro Gln  Ser Leu Lys 
    1355                 1360                 1365             


Val Gly  Ser Phe Ile Ile Glu  Leu Ala Ser Gln Arg  Lys Ser Arg 
    1370                 1375                 1380             


Gly Glu  Lys Asn Pro Pro Val  Tyr Ser Ser Arg Val  Lys Ile Ser 
    1385                 1390                 1395             


Met Pro  Ser Cys Gln Asp Gln  Asp Asp Met Ala Glu  Lys Ser Gly 
    1400                 1405                 1410             


Ser Glu  Thr Pro Asp Gly Pro  Leu Ser Pro Gly Lys  Met Glu Asp 
    1415                 1420                 1425             


Ile Ser  Pro Val Gln Thr Asp  Ala Leu Asp Ser Val  Arg Glu Arg 
    1430                 1435                 1440             


Leu His  Gly Gly Lys Gly Leu  Pro Phe Tyr Ala Gly  Leu Ser Pro 
    1445                 1450                 1455             


Ala Gly  Lys Leu Val Ala Tyr  Lys Arg Lys Pro Ser  Ser Ser Thr 
    1460                 1465                 1470             


Ser Gly  Leu Ile Gln Val Ala  Ser Asn Ala Lys Val  Ala Ala Ser 
    1475                 1480                 1485             


Arg Lys  Pro Arg Thr Leu Leu  Pro Ser Thr Ser Asn  Ser Lys Met 
    1490                 1495                 1500             


Ala Ser  Ser Ser Gly Thr Ala  Thr Asn Arg Pro Gly  Lys Asn Leu 
    1505                 1510                 1515             


Lys Ala  Phe Val Pro Ala Lys  Arg Pro Ile Glu Asn  Ala Ala Gln 
    1520                 1525                 1530             


Ile Pro  Val Ala Thr Pro Gln  Val Ser Pro Asn Thr  Val Lys Arg 
    1535                 1540                 1545             


Ala Gly  Pro Arg Leu Leu Leu  Ile Pro Val Gln Gln  Gly Ser Pro 
    1550                 1555                 1560             


Thr Leu  Arg Pro Val Ser Asn  Thr Gln Leu Gln Gly  His Arg Met 
    1565                 1570                 1575             


Val Leu  Gln Pro Val Arg Ser  Pro Ser Gly Met Asn  Leu Phe Arg 
    1580                 1585                 1590             


His Pro  Asn Gly Gln Ile Val  Gln Leu Leu Pro Leu  His Gln Leu 
    1595                 1600                 1605             


Arg Gly  Ser Asn Thr Gln Pro  Asn Leu Gln Pro Val  Met Phe Arg 
    1610                 1615                 1620             


Asn Pro  Gly Ser Val Met Gly  Ile Arg Leu Pro Ala  Pro Ser Lys 
    1625                 1630                 1635             


Pro Ser  Glu Thr Pro Pro Ser  Ser Thr Ser Ser Ser  Ala Phe Ser 
    1640                 1645                 1650             


Val Met  Asn Pro Val Ile Gln  Ala Val Gly Ser Ser  Ser Ala Val 
    1655                 1660                 1665             


Asn Val  Ile Thr Gln Ala Pro  Ser Leu Leu Ser Ser  Gly Ala Ser 
    1670                 1675                 1680             


Phe Val  Ser Gln Ala Gly Thr  Leu Thr Leu Arg Ile  Ser Pro Pro 
    1685                 1690                 1695             


Glu Pro  Gln Ser Phe Ala Ser  Lys Thr Gly Ser Glu  Thr Lys Ile 
    1700                 1705                 1710             


Thr Tyr  Ser Ser Gly Gly Gln  Pro Val Gly Thr Ala  Ser Leu Ile 
    1715                 1720                 1725             


Pro Leu  Gln Ser Gly Ser Phe  Ala Leu Leu Gln Leu  Pro Gly Gln 
    1730                 1735                 1740             


Lys Pro  Val Pro Ser Ser Ile  Leu Gln His Val Ala  Ser Leu Gln 
    1745                 1750                 1755             


Met Lys  Arg Glu Ser Gln Asn  Pro Asp Gln Lys Asp  Glu Thr Asn 
    1760                 1765                 1770             


Ser Ile  Lys Arg Glu Gln Glu  Thr Lys Lys Val Leu  Gln Ser Glu 
    1775                 1780                 1785             


Gly Glu  Ala Val Asp Pro Glu  Ala Asn Val Ile Lys  Gln Asn Ser 
    1790                 1795                 1800             


Gly Ala  Ala Thr Ser Glu Glu  Thr Leu Asn Asp Ser  Leu Glu Asp 
    1805                 1810                 1815             


Arg Gly  Asp His Leu Asp Glu  Glu Cys Leu Pro Glu  Glu Gly Cys 
    1820                 1825                 1830             


Ala Thr  Val Lys Pro Ser Glu  His Ser Cys Ile Thr  Gly Ser His 
    1835                 1840                 1845             


Thr Asp  Gln Asp Tyr Lys Asp  Val Asn Glu Glu Tyr  Gly Ala Arg 
    1850                 1855                 1860             


Asn Arg  Lys Ser Ser Lys Glu  Lys Val Ala Val Leu  Glu Val Arg 
    1865                 1870                 1875             


Thr Ile  Ser Glu Lys Ala Ser  Asn Lys Thr Val Gln  Asn Leu Ser 
    1880                 1885                 1890             


Lys Val  Gln His Gln Lys Leu  Gly Asp Val Lys Val  Glu Gln Gln 
    1895                 1900                 1905             


Lys Gly  Phe Asp Asn Pro Glu  Glu Asn Ser Ser Glu  Phe Pro Val 
    1910                 1915                 1920             


Thr Phe  Lys Glu Glu Ser Lys  Phe Glu Leu Ser Gly  Ser Lys Val 
    1925                 1930                 1935             


Met Glu  Gln Gln Ser Asn Leu  Gln Pro Glu Ala Lys  Glu Lys Glu 
    1940                 1945                 1950             


Cys Gly  Asp Ser Leu Glu Lys  Asp Arg Glu Arg Trp  Arg Lys His 
    1955                 1960                 1965             


Leu Lys  Gly Pro Leu Thr Arg  Lys Cys Val Gly Ala  Ser Gln Glu 
    1970                 1975                 1980             


Cys Lys  Lys Glu Ala Asp Glu  Gln Leu Ile Lys Glu  Thr Lys Thr 
    1985                 1990                 1995             


Cys Gln  Glu Asn Ser Asp Val  Phe Gln Gln Glu Gln  Gly Ile Ser 
    2000                 2005                 2010             


Asp Leu  Leu Gly Lys Ser Gly  Ile Thr Glu Asp Ala  Arg Val Leu 
    2015                 2020                 2025             


Lys Thr  Glu Cys Asp Ser Trp  Ser Arg Ile Ser Asn  Pro Ser Ala 
    2030                 2035                 2040             


Phe Ser  Ile Val Pro Arg Arg  Ala Ala Lys Ser Ser  Arg Gly Asn 
    2045                 2050                 2055             


Gly His  Phe Gln Gly His Leu  Leu Leu Pro Gly Glu  Gln Ile Gln 
    2060                 2065                 2070             


Pro Lys  Gln Glu Lys Lys Gly  Gly Arg Ser Ser Ala  Asp Phe Thr 
    2075                 2080                 2085             


Val Leu  Asp Leu Glu Glu Asp  Asp Glu Asp Asp Asn  Glu Lys Thr 
    2090                 2095                 2100             


Asp Asp  Ser Ile Asp Glu Ile  Val Asp Val Val Ser  Asp Tyr Gln 
    2105                 2110                 2115             


Ser Glu  Glu Val Asp Asp Val  Glu Lys Asn Asn Cys  Val Glu Tyr 
    2120                 2125                 2130             


Ile Glu  Asp Asp Glu Glu His  Val Asp Ile Glu Thr  Val Glu Glu 
    2135                 2140                 2145             


Leu Ser  Glu Glu Ile Asn Val  Ala His Leu Lys Thr  Thr Ala Ala 
    2150                 2155                 2160             


His Thr  Gln Ser Phe Lys Gln  Pro Ser Cys Thr His  Ile Ser Ala 
    2165                 2170                 2175             


Asp Glu  Lys Ala Ala Glu Arg  Ser Arg Lys Ala Pro  Pro Ile Pro 
    2180                 2185                 2190             


Leu Lys  Leu Lys Pro Asp Tyr  Trp Ser Asp Lys Leu  Gln Lys Glu 
    2195                 2200                 2205             


Ala Glu  Ala Phe Ala Tyr Tyr  Arg Arg Thr His Thr  Ala Asn Glu 
    2210                 2215                 2220             


Arg Arg  Arg Arg Gly Glu Met  Arg Asp Leu Phe Glu  Lys Leu Lys 
    2225                 2230                 2235             


Ile Thr  Leu Gly Leu Leu His  Ser Ser Lys Val Ser  Lys Ser Leu 
    2240                 2245                 2250             


Ile Leu  Thr Arg Ala Phe Ser  Glu Ile Gln Gly Leu  Thr Asp Gln 
    2255                 2260                 2265             


Ala Asp  Lys Leu Ile Gly Gln  Lys Asn Leu Leu Thr  Arg Lys Arg 
    2270                 2275                 2280             


Asn Ile  Leu Ile Arg Lys Val  Ser Ser Leu Ser Gly  Lys Thr Glu 
    2285                 2290                 2295             


Glu Val  Val Leu Lys Lys Leu  Glu Tyr Ile Tyr Ala  Lys Gln Gln 
    2300                 2305                 2310             


Ala Leu  Glu Ala Gln Lys Arg  Lys Lys Lys Met Gly  Ser Asp Glu 
    2315                 2320                 2325             


Phe Asp  Ile Ser Pro Arg Ile  Ser Lys Gln Gln Glu  Gly Ser Ser 
    2330                 2335                 2340             


Ala Ser  Ser Val Asp Leu Gly  Gln Met Phe Ile Asn  Asn Arg Arg 
    2345                 2350                 2355             


Gly Lys  Pro Leu Ile Leu Ser  Arg Lys Lys Asp Gln  Ala Thr Glu 
    2360                 2365                 2370             


Asn Thr  Ser Pro Leu Asn Thr  Pro His Thr Ser Ala  Asn Leu Val 
    2375                 2380                 2385             


Met Thr  Pro Gln Gly Gln Leu  Leu Thr Leu Lys Gly  Pro Leu Phe 
    2390                 2395                 2400             


Ser Gly  Pro Val Val Ala Val  Ser Pro Asp Leu Leu  Glu Ser Asp 
    2405                 2410                 2415             


Leu Lys  Pro Gln Val Ala Gly  Ser Ala Val Ala Leu  Pro Glu Asn 
    2420                 2425                 2430             


Asp Asp  Leu Phe Met Met Pro  Arg Ile Val Asn Val  Thr Ser Leu 
    2435                 2440                 2445             


Ala Thr  Glu Gly Gly Leu Val  Asp Met Gly Gly Ser  Lys Tyr Pro 
    2450                 2455                 2460             


His Glu  Val Pro Asp Ser Lys  Pro Ser Asp His Leu  Lys Asp Thr 
    2465                 2470                 2475             


Val Arg  Asn Glu Asp Asn Ser  Leu Glu Asp Lys Gly  Arg Ile Ser 
    2480                 2485                 2490             


Ser Arg  Gly Asn Arg Asp Gly  Arg Val Thr Leu Gly  Pro Thr Gln 
    2495                 2500                 2505             


Val Phe  Leu Ala Asn Lys Asp  Ser Gly Tyr Pro Gln  Ile Val Asp 
    2510                 2515                 2520             


Val Ser  Asn Met Gln Lys Ala  Gln Glu Phe Leu Pro  Lys Lys Ile 
    2525                 2530                 2535             


Ser Gly  Asp Met Arg Gly Ile  Gln Tyr Lys Trp Lys  Glu Ser Glu 
    2540                 2545                 2550             


Ser Arg  Gly Glu Arg Val Lys  Ser Lys Asp Ser Ser  Phe His Lys 
    2555                 2560                 2565             


Leu Lys  Met Lys Asp Leu Lys  Asp Ser Ser Ile Glu  Met Glu Leu 
    2570                 2575                 2580             


Arg Lys  Val Thr Ser Ala Ile  Glu Glu Ala Ala Leu  Asp Ser Ser 
    2585                 2590                 2595             


Glu Leu  Leu Thr Asn Met Glu  Asp Glu Asp Asp Thr  Asp Glu Thr 
    2600                 2605                 2610             


Leu Thr  Ser Leu Leu Asn Glu  Ile Ala Phe Leu Asn  Gln Gln Leu 
    2615                 2620                 2625             


Asn Asp  Asp Ser Val Gly Leu  Ala Glu Leu Pro Ser  Ser Met Asp 
    2630                 2635                 2640             


Thr Glu  Phe Pro Gly Asp Ala  Arg Arg Ala Phe Ile  Ser Lys Val 
    2645                 2650                 2655             


Pro Pro  Gly Ser Arg Ala Thr  Phe Gln Val Glu His  Leu Gly Thr 
    2660                 2665                 2670             


Gly Leu  Lys Glu Leu Pro Asp  Val Gln Gly Glu Ser  Asp Ser Ile 
    2675                 2680                 2685             


Ser Pro  Leu Leu Leu His Leu  Glu Asp Asp Asp Phe  Ser Glu Asn 
    2690                 2695                 2700             


Glu Lys  Gln Leu Ala Glu Pro  Ala Ser Glu Pro Asp  Val Leu Lys 
    2705                 2710                 2715             


Ile Val  Ile Asp Ser Glu Ile  Lys Asp Ser Leu Leu  Ser Asn Lys 
    2720                 2725                 2730             


Lys Ala  Ile Asp Gly Gly Lys  Asn Thr Ser Gly Leu  Pro Ala Glu 
    2735                 2740                 2745             


Pro Glu  Ser Val Ser Ser Pro  Pro Thr Leu His Met  Lys Thr Gly 
    2750                 2755                 2760             


Leu Glu  Asn Ser Asn Ser Thr  Asp Thr Leu Trp Arg  Pro Met Pro 
    2765                 2770                 2775             


Lys Leu  Ala Pro Leu Gly Leu  Lys Val Ala Asn Pro  Ser Ser Asp 
    2780                 2785                 2790             


Ala Asp  Gly Gln Ser Leu Lys  Val Met Pro Cys Leu  Ala Pro Ile 
    2795                 2800                 2805             


Ala Ala  Lys Val Gly Ser Val  Gly His Lys Met Asn  Leu Thr Gly 
    2810                 2815                 2820             


Asn Asp  Gln Glu Gly Arg Glu  Ser Lys Val Met Pro  Thr Leu Ala 
    2825                 2830                 2835             


Pro Val  Val Ala Lys Leu Gly  Asn Ser Gly Ala Ser  Pro Ser Ser 
    2840                 2845                 2850             


Ala Gly  Lys 
    2855     


<210>  52
<211>  1174
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  52

Xaa Leu Thr Cys Asp Leu Glu Asp Asp Ser Asp Lys Leu Gln Glu Lys 
1               5                   10                  15      


Ser Trp Lys Ser Ser Cys Asn Glu Gly Glu Ser Ser Ser Thr Ser Tyr 
            20                  25                  30          


Met His Gln Arg Ser Pro Gly Gly Pro Thr Lys Leu Ile Glu Ile Ile 
        35                  40                  45              


Ser Asp Cys Asn Trp Glu Glu Asp Arg Asn Lys Ile Leu Ser Ile Leu 
    50                  55                  60                  


Ser Gln His Ile Asn Ser Asn Met Pro Gln Ser Leu Lys Val Asn Gly 
65                  70                  75                  80  


Lys Ser Tyr Pro Gln Ala Lys Leu Leu Leu Gly Gln Met Gly Ala Leu 
                85                  90                  95      


His Pro Ala Asn Arg Leu Ala Ala Tyr Ile Thr Gly Arg Leu Arg Pro 
            100                 105                 110         


Ser Val Leu Asp Leu Ser Thr Leu Ser Thr Val Ile Ser Lys Val Ala 
        115                 120                 125             


Ser Asn Ala Lys Val Ala Ala Ser Arg Lys Pro Arg Thr Leu Leu Pro 
    130                 135                 140                 


Ser Thr Ser Asn Ser Lys Met Ala Ser Ser Ser Gly Thr Ala Thr Asn 
145                 150                 155                 160 


Arg Pro Gly Lys Asn Leu Lys Ala Phe Val Pro Ala Lys Arg Pro Ile 
                165                 170                 175     


Ala Ala Arg Pro Ser Pro Gly Gly Val Phe Thr Gln Phe Val Met Ser 
            180                 185                 190         


Lys Val Gly Ala Leu Gln Gln Lys Ile Pro Gly Val Ser Thr Pro Gln 
        195                 200                 205             


Thr Leu Ala Gly Thr Gln Lys Phe Ser Ile Arg Pro Ser Pro Val Met 
    210                 215                 220                 


Val Val Thr Pro Val Val Ser Ser Glu Pro Val Gln Val Cys Ser Pro 
225                 230                 235                 240 


Val Thr Ala Ala Val Thr Thr Thr Thr Pro Gln Val Phe Leu Glu Asn 
                245                 250                 255     


Thr Thr Ala Val Thr Pro Met Thr Ala Ile Ser Asp Val Glu Thr Lys 
            260                 265                 270         


Glu Thr Thr Tyr Ser Ser Gly Ala Thr Thr Thr Gly Val Val Glu Val 
        275                 280                 285             


Ser Glu Thr Asn Thr Ser Thr Ser Val Thr Ser Thr Gln Ser Thr Ala 
    290                 295                 300                 


Thr Val Asn Leu Thr Lys Thr Thr Gly Ile Thr Thr Pro Val Ala Ser 
305                 310                 315                 320 


Val Ala Phe Pro Lys Ser Leu Val Ala Ser Pro Ser Thr Ile Thr Leu 
                325                 330                 335     


Pro Val Ala Ser Thr Ala Ser Thr Ser Leu Val Val Val Thr Ala Ala 
            340                 345                 350         


Ala Ser Ser Ser Met Val Thr Thr Pro Thr Ser Ser Leu Gly Ser Val 
        355                 360                 365             


Pro Ile Ile Leu Ser Gly Ile Asn Gly Ser Pro Pro Val Ser Gln Arg 
    370                 375                 380                 


Pro Glu Asn Ala Ala Gln Ile Pro Val Ala Thr Pro Gln Val Ser Pro 
385                 390                 395                 400 


Asn Thr Val Lys Arg Ala Gly Pro Arg Leu Leu Leu Ile Pro Val Gln 
                405                 410                 415     


Gln Gly Ser Pro Thr Leu Arg Pro Val Ser Asn Thr Gln Leu Gln Gly 
            420                 425                 430         


His Arg Met Val Leu Gln Pro Val Arg Ser Pro Ser Gly Met Asn Leu 
        435                 440                 445             


Phe Arg His Pro Asn Gly Gln Ile Val Gln Leu Leu Pro Leu His Gln 
    450                 455                 460                 


Leu Arg Gly Ser Asn Thr Gln Pro Asn Leu Gln Pro Val Met Phe Arg 
465                 470                 475                 480 


Asn Pro Gly Ser Val Met Gly Ile Arg Leu Pro Ala Pro Ser Lys Pro 
                485                 490                 495     


Ser Glu Thr Pro Pro Ser Ser Thr Ser Ser Ser Ala Phe Ser Val Met 
            500                 505                 510         


Asn Pro Val Ile Gln Ala Val Gly Ser Ser Ser Ala Val Asn Val Ile 
        515                 520                 525             


Thr Gln Ala Pro Ser Leu Leu Ser Ser Gly Ala Ser Phe Val Ser Gln 
    530                 535                 540                 


Ala Gly Thr Leu Thr Leu Arg Ile Ser Pro Pro Glu Pro Gln Ser Phe 
545                 550                 555                 560 


Ala Ser Lys Thr Gly Ser Glu Thr Lys Ile Thr Tyr Ser Ser Gly Gly 
                565                 570                 575     


Gln Pro Val Gly Thr Ala Ser Leu Ile Pro Leu Gln Ser Gly Ser Phe 
            580                 585                 590         


Ala Leu Leu Gln Leu Pro Gly Gln Lys Pro Val Pro Ser Ser Ile Leu 
        595                 600                 605             


Gln His Val Ala Ser Leu Gln Met Lys Arg Glu Ser Gln Asn Pro Asp 
    610                 615                 620                 


Gln Lys Asp Glu Thr Asn Ser Ile Lys Arg Glu Gln Glu Thr Lys Lys 
625                 630                 635                 640 


Val Leu Gln Ser Glu Gly Glu Ala Val Asp Pro Glu Ala Asn Val Ile 
                645                 650                 655     


Lys Gln Asn Ser Gly Ala Ala Thr Ser Glu Glu Thr Leu Asn Asp Ser 
            660                 665                 670         


Leu Glu Asp Arg Gly Asp His Leu Asp Glu Glu Cys Leu Pro Glu Glu 
        675                 680                 685             


Gly Cys Ala Thr Val Lys Pro Ser Glu His Ser Cys Ile Thr Gly Ser 
    690                 695                 700                 


His Thr Asp Gln Asp Tyr Lys Asp Val Asn Glu Glu Tyr Gly Ala Arg 
705                 710                 715                 720 


Asn Arg Lys Ser Ser Lys Glu Lys Val Ala Val Leu Glu Val Arg Thr 
                725                 730                 735     


Ile Ser Glu Lys Ala Ser Asn Lys Thr Val Gln Asn Leu Ser Lys Val 
            740                 745                 750         


Gln His Gln Lys Leu Gly Asp Val Lys Val Glu Gln Gln Lys Gly Phe 
        755                 760                 765             


Asp Asn Pro Glu Glu Asn Ser Ser Glu Phe Pro Val Thr Phe Lys Glu 
    770                 775                 780                 


Glu Ser Lys Phe Glu Leu Ser Gly Ser Lys Val Met Glu Gln Gln Ser 
785                 790                 795                 800 


Asn Leu Gln Pro Glu Ala Lys Glu Lys Glu Cys Gly Asp Ser Leu Glu 
                805                 810                 815     


Lys Asp Arg Glu Arg Trp Arg Lys His Leu Lys Gly Pro Leu Thr Arg 
            820                 825                 830         


Lys Cys Val Gly Ala Ser Gln Glu Cys Lys Lys Glu Ala Asp Glu Gln 
        835                 840                 845             


Leu Ile Lys Glu Thr Lys Thr Cys Gln Glu Asn Ser Asp Val Phe Gln 
    850                 855                 860                 


Gln Glu Gln Gly Ile Ser Asp Leu Leu Gly Lys Ser Gly Ile Thr Glu 
865                 870                 875                 880 


Asp Ala Arg Val Leu Lys Thr Glu Cys Asp Ser Trp Ser Arg Ile Ser 
                885                 890                 895     


Asn Pro Ser Ala Phe Ser Ile Val Pro Arg Arg Ala Ala Lys Ser Ser 
            900                 905                 910         


Arg Gly Asn Gly His Phe Gln Gly His Leu Leu Leu Pro Gly Glu Gln 
        915                 920                 925             


Ile Gln Pro Lys Gln Glu Lys Lys Gly Gly Arg Ser Ser Ala Asp Phe 
    930                 935                 940                 


Thr Val Leu Asp Leu Glu Glu Asp Asp Glu Asp Asp Asn Glu Lys Thr 
945                 950                 955                 960 


Asp Asp Ser Ile Asp Glu Ile Val Asp Val Val Ser Asp Tyr Gln Ser 
                965                 970                 975     


Glu Glu Val Asp Asp Val Glu Lys Asn Asn Cys Val Glu Tyr Ile Glu 
            980                 985                 990         


Asp Asp Glu Glu His Val Asp Ile  Glu Thr Val Glu Glu  Leu Ser Glu 
        995                 1000                 1005             


Glu Ile  Asn Val Ala His Leu  Lys Thr Thr Ala Ala  His Thr Gln 
    1010                 1015                 1020             


Ser Phe  Lys Gln Pro Ser Cys  Thr His Ile Ser Ala  Asp Glu Lys 
    1025                 1030                 1035             


Ala Ala  Glu Arg Ser Arg Lys  Ala Pro Pro Ile Pro  Leu Lys Leu 
    1040                 1045                 1050             


Lys Pro  Asp Tyr Trp Ser Asp  Lys Leu Gln Lys Glu  Ala Glu Ala 
    1055                 1060                 1065             


Phe Ala  Tyr Tyr Arg Arg Thr  His Thr Ala Asn Glu  Arg Arg Arg 
    1070                 1075                 1080             


Arg Gly  Glu Met Arg Asp Leu  Phe Glu Lys Leu Lys  Ile Thr Leu 
    1085                 1090                 1095             


Gly Leu  Leu His Ser Ser Lys  Val Ser Lys Ser Leu  Ile Leu Thr 
    1100                 1105                 1110             


Arg Ala  Phe Ser Glu Ile Gln  Gly Leu Thr Asp Gln  Ala Asp Lys 
    1115                 1120                 1125             


Leu Ile  Gly Gln Lys Asn Leu  Leu Thr Arg Lys Arg  Asn Ile Leu 
    1130                 1135                 1140             


Ile Arg  Lys Val Ser Ser Leu  Ser Gly Lys Thr Glu  Glu Val Val 
    1145                 1150                 1155             


Leu Lys  Lys Leu Glu Tyr Ile  Tyr Ala Lys Gln Gln  Ala Leu Glu 
    1160                 1165                 1170             


Ala 
    


<210>  53
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Lys Phe Leu Phe Leu Phe Phe Leu Arg Gln Ser Leu Thr Leu Ser 
1               5                   10                  15      


Pro Arg Leu Glu Cys Ser Gly Ala Val Leu Ala His Cys Lys Leu Cys 
            20                  25                  30          


Leu Pro Gly Leu Arg His Cys Pro Ala Pro Ala Thr Arg Glu Ala Glu 
        35                  40                  45              


Ala Arg Glu Trp Leu Glu Thr Arg Ser Arg Arg Leu Gln 
    50                  55                  60      


<210>  54
<211>  1086
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Glu Glu Lys Gln Gln Ile Ile Leu Ala Asn Gln Asp Gly Gly Thr 
1               5                   10                  15      


Val Ala Gly Ala Ala Pro Thr Phe Phe Val Ile Leu Lys Gln Pro Gly 
            20                  25                  30          


Asn Gly Lys Thr Asp Gln Gly Ile Leu Val Thr Asn Gln Asp Ala Cys 
        35                  40                  45              


Ala Leu Ala Ser Ser Val Ser Ser Pro Val Lys Ser Lys Gly Lys Ile 
    50                  55                  60                  


Cys Leu Pro Ala Asp Cys Thr Val Gly Gly Ile Thr Val Thr Leu Asp 
65                  70                  75                  80  


Asn Asn Ser Met Trp Asn Glu Phe Tyr His Arg Ser Thr Glu Met Ile 
                85                  90                  95      


Leu Thr Lys Gln Gly Arg Arg Met Phe Pro Tyr Cys Arg Tyr Trp Ile 
            100                 105                 110         


Thr Gly Leu Asp Ser Asn Leu Lys Tyr Ile Leu Val Met Asp Ile Ser 
        115                 120                 125             


Pro Val Asp Asn His Arg Tyr Lys Trp Asn Gly Arg Trp Trp Glu Pro 
    130                 135                 140                 


Ser Gly Lys Ala Glu Pro His Val Leu Gly Arg Val Phe Ile His Pro 
145                 150                 155                 160 


Glu Ser Pro Ser Thr Gly His Tyr Trp Met His Gln Pro Val Ser Phe 
                165                 170                 175     


Tyr Lys Leu Lys Leu Thr Asn Asn Thr Leu Asp Gln Glu Gly His Ile 
            180                 185                 190         


Ile Leu His Ser Met His Arg Tyr Leu Pro Arg Leu His Leu Val Pro 
        195                 200                 205             


Ala Glu Lys Ala Val Glu Val Ile Gln Leu Asn Gly Pro Gly Val His 
    210                 215                 220                 


Thr Phe Thr Phe Pro Gln Thr Glu Phe Phe Ala Val Thr Ala Tyr Gln 
225                 230                 235                 240 


Asn Ile Gln Ile Thr Gln Leu Lys Ile Asp Tyr Asn Pro Phe Ala Lys 
                245                 250                 255     


Gly Phe Arg Asp Asp Gly Leu Asn Asn Lys Pro Gln Arg Asp Gly Lys 
            260                 265                 270         


Gln Lys Asn Ser Ser Asp Gln Glu Gly Asn Asn Ile Ser Ser Ser Ser 
        275                 280                 285             


Gly His Arg Val Arg Leu Thr Glu Gly Gln Gly Ser Glu Ile Gln Pro 
    290                 295                 300                 


Gly Asp Leu Asp Pro Leu Ser Arg Gly His Glu Thr Ser Gly Lys Gly 
305                 310                 315                 320 


Leu Glu Lys Thr Ser Leu Asn Ile Lys Arg Asp Phe Leu Gly Phe Met 
                325                 330                 335     


Asp Thr Asp Ser Ala Leu Ser Glu Val Pro Gln Leu Lys Gln Glu Ile 
            340                 345                 350         


Ser Glu Cys Leu Ile Ala Ser Ser Phe Glu Asp Asp Ser Arg Val Ala 
        355                 360                 365             


Ser Pro Leu Asp Gln Asn Gly Ser Phe Asn Val Val Ile Lys Glu Glu 
    370                 375                 380                 


Pro Leu Asp Asp Tyr Asp Tyr Glu Leu Gly Glu Cys Pro Glu Gly Val 
385                 390                 395                 400 


Thr Val Lys Gln Glu Glu Thr Asp Glu Glu Thr Asp Val Tyr Ser Asn 
                405                 410                 415     


Ser Asp Asp Asp Pro Ile Leu Glu Lys Gln Leu Lys Arg His Asn Lys 
            420                 425                 430         


Val Asp Asn Pro Glu Ala Asp His Leu Ser Ser Lys Trp Leu Pro Ser 
        435                 440                 445             


Ser Pro Ser Gly Val Ala Lys Ala Lys Met Phe Lys Leu Asp Thr Gly 
    450                 455                 460                 


Lys Met Pro Val Val Tyr Leu Glu Pro Cys Ala Val Thr Arg Ser Thr 
465                 470                 475                 480 


Val Lys Ile Ser Glu Leu Pro Asp Asn Met Leu Ser Thr Ser Arg Lys 
                485                 490                 495     


Asp Lys Ser Ser Met Leu Ala Glu Leu Glu Tyr Leu Pro Thr Tyr Ile 
            500                 505                 510         


Glu Asn Ser Asn Glu Thr Ala Phe Cys Leu Gly Lys Glu Ser Glu Asn 
        515                 520                 525             


Gly Leu Arg Lys His Ser Pro Asp Leu Arg Val Val Gln Lys Tyr Pro 
    530                 535                 540                 


Leu Leu Lys Glu Pro Gln Trp Lys Tyr Pro Asp Ile Ser Asp Ser Ile 
545                 550                 555                 560 


Ser Thr Glu Arg Ile Leu Asp Asp Ser Lys Asp Ser Val Gly Asp Ser 
                565                 570                 575     


Leu Ser Gly Lys Glu Asp Leu Gly Arg Lys Arg Thr Thr Met Leu Lys 
            580                 585                 590         


Ile Ala Thr Ala Ala Lys Val Val Asn Ala Asn Gln Asn Ala Ser Pro 
        595                 600                 605             


Asn Val Pro Gly Lys Arg Gly Arg Pro Arg Lys Leu Lys Leu Cys Lys 
    610                 615                 620                 


Ala Gly Arg Pro Pro Lys Asn Thr Gly Lys Ser Leu Ile Ser Thr Lys 
625                 630                 635                 640 


Asn Thr Pro Val Ser Pro Gly Ser Thr Phe Pro Asp Val Lys Pro Asp 
                645                 650                 655     


Leu Glu Asp Val Asp Gly Val Leu Phe Val Ser Phe Glu Ser Lys Glu 
            660                 665                 670         


Ala Leu Asp Ile His Ala Val Asp Gly Thr Thr Glu Glu Ser Ser Ser 
        675                 680                 685             


Leu Gln Ala Ser Thr Thr Asn Asp Ser Gly Tyr Arg Ala Arg Ile Ser 
    690                 695                 700                 


Gln Leu Glu Lys Glu Leu Ile Glu Asp Leu Lys Thr Leu Arg His Lys 
705                 710                 715                 720 


Gln Val Ile His Pro Gly Leu Gln Glu Val Gly Leu Lys Leu Asn Ser 
                725                 730                 735     


Val Asp Pro Thr Met Ser Ile Asp Leu Lys Tyr Leu Gly Val Gln Leu 
            740                 745                 750         


Pro Leu Ala Pro Ala Thr Ser Phe Pro Phe Trp Asn Leu Thr Gly Thr 
        755                 760                 765             


Asn Pro Ala Ser Pro Asp Ala Gly Phe Pro Phe Val Ser Arg Thr Gly 
    770                 775                 780                 


Lys Thr Asn Asp Phe Thr Lys Ile Lys Gly Trp Arg Gly Lys Phe His 
785                 790                 795                 800 


Ser Ala Ser Ala Ser Arg Asn Glu Gly Gly Asn Ser Glu Ser Ser Leu 
                805                 810                 815     


Lys Asn Arg Ser Ala Phe Cys Ser Asp Lys Leu Asp Glu Tyr Leu Glu 
            820                 825                 830         


Asn Glu Gly Lys Leu Met Glu Thr Ser Met Gly Phe Ser Ser Asn Ala 
        835                 840                 845             


Pro Thr Ser Pro Val Val Tyr Gln Leu Pro Thr Lys Ser Thr Ser Tyr 
    850                 855                 860                 


Val Arg Thr Leu Asp Ser Val Leu Lys Lys Gln Ser Thr Ile Ser Pro 
865                 870                 875                 880 


Ser Thr Ser Tyr Ser Leu Lys Pro His Ser Val Pro Pro Val Ser Arg 
                885                 890                 895     


Lys Ala Lys Ser Gln Asn Arg Gln Ala Thr Phe Ser Gly Arg Thr Lys 
            900                 905                 910         


Ser Ser Tyr Lys Ser Ile Leu Pro Tyr Pro Val Ser Pro Lys Gln Lys 
        915                 920                 925             


Tyr Ser His Val Ile Leu Gly Asp Lys Val Thr Lys Asn Ser Ser Gly 
    930                 935                 940                 


Ile Ile Ser Glu Asn Gln Ala Asn Asn Phe Val Val Pro Thr Leu Asp 
945                 950                 955                 960 


Glu Asn Ile Phe Pro Lys Gln Ile Ser Leu Arg Gln Ala Gln Gln Gln 
                965                 970                 975     


Gln Gln Gln Gln Gln Gly Ser Arg Pro Pro Gly Leu Ser Lys Ser Gln 
            980                 985                 990         


Val Lys Leu Met Asp Leu Glu Asp  Cys Ala Leu Trp Glu  Gly Lys Pro 
        995                 1000                 1005             


Arg Thr  Tyr Ile Thr Glu Glu  Arg Ala Asp Val Ser  Leu Thr Thr 
    1010                 1015                 1020             


Leu Leu  Thr Ala Gln Ala Ser  Leu Lys Thr Lys Pro  Ile His Thr 
    1025                 1030                 1035             


Ile Ile  Arg Lys Arg Ala Pro  Pro Cys Asn Asn Asp  Phe Cys Arg 
    1040                 1045                 1050             


Leu Gly  Cys Val Cys Ser Ser  Leu Ala Leu Glu Lys  Arg Gln Pro 
    1055                 1060                 1065             


Ala His  Cys Arg Arg Pro Asp  Cys Met Phe Gly Cys  Thr Cys Leu 
    1070                 1075                 1080             


Lys Arg  Lys 
    1085     


<210>  55
<211>  83
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  55

Xaa Asp Gln Glu Gly Asn Asn Ile Ser Ser Ser Ser Gly His Arg Val 
1               5                   10                  15      


Arg Leu Thr Glu Gly Gln Gly Ser Glu Ile Gln Pro Gly Asp Leu Asp 
            20                  25                  30          


Pro Leu Ser Arg Gly His Glu Thr Ser Gly Lys Gly Leu Glu Lys Thr 
        35                  40                  45              


Ser Leu Asn Ile Lys Arg Asp Phe Leu Gly Phe Met Asp Thr Asp Ser 
    50                  55                  60                  


Ala Leu Ser Glu Val Pro Gln Leu Lys Gln Glu Ile Ser Glu Trp Tyr 
65                  70                  75                  80  


Ser Phe Ala 
            


<210>  56
<211>  706
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Asn Glu Ser Lys Pro Gly Asp Ser Gln Asn Leu Ala Cys Val Phe 
1               5                   10                  15      


Cys Arg Lys His Asp Asp Cys Pro Asn Lys Tyr Gly Glu Lys Lys Thr 
            20                  25                  30          


Lys Glu Lys Trp Asn Leu Thr Val His Tyr Tyr Cys Leu Leu Met Ser 
        35                  40                  45              


Ser Gly Ile Trp Gln Arg Gly Lys Glu Glu Glu Gly Val Tyr Gly Phe 
    50                  55                  60                  


Leu Ile Glu Asp Ile Arg Lys Glu Val Asn Arg Ala Ser Lys Leu Lys 
65                  70                  75                  80  


Cys Cys Val Cys Lys Lys Asn Gly Ala Ser Ile Gly Cys Val Ala Pro 
                85                  90                  95      


Arg Cys Lys Arg Ser Tyr His Phe Pro Cys Gly Leu Gln Arg Glu Cys 
            100                 105                 110         


Ile Phe Gln Phe Thr Gly Asn Phe Ala Ser Phe Cys Trp Asp His Arg 
        115                 120                 125             


Pro Val Gln Ile Ile Thr Ser Asn Asn Tyr Arg Glu Ser Leu Pro Cys 
    130                 135                 140                 


Thr Ile Cys Leu Glu Phe Ile Glu Pro Ile Pro Ser Tyr Asn Ile Leu 
145                 150                 155                 160 


Arg Ser Pro Cys Cys Lys Asn Ala Trp Phe His Arg Asp Cys Leu Gln 
                165                 170                 175     


Val Gln Ala Ile Asn Ala Gly Val Phe Phe Phe Arg Cys Thr Ile Cys 
            180                 185                 190         


Asn Asn Ser Asp Ile Phe Gln Lys Glu Met Leu Arg Met Gly Ile His 
        195                 200                 205             


Ile Pro Glu Lys Asp Ala Ser Trp Glu Leu Glu Glu Asn Ala Tyr Gln 
    210                 215                 220                 


Glu Leu Leu Gln His Tyr Glu Arg Cys Asp Val Arg Arg Cys Arg Cys 
225                 230                 235                 240 


Lys Glu Gly Arg Asp Tyr Asn Ala Pro Asp Ser Lys Trp Glu Ile Lys 
                245                 250                 255     


Arg Cys Gln Cys Cys Gly Ser Ser Gly Thr His Leu Ala Cys Ser Ser 
            260                 265                 270         


Leu Arg Ser Trp Glu Gln Asn Trp Glu Cys Leu Glu Cys Arg Gly Ile 
        275                 280                 285             


Ile Tyr Asn Ser Gly Glu Phe Gln Lys Ala Lys Lys His Val Leu Pro 
    290                 295                 300                 


Asn Ser Asn Asn Val Gly Ile Thr Asp Cys Leu Leu Glu Glu Ser Ser 
305                 310                 315                 320 


Pro Lys Leu Pro Arg Gln Ser Pro Gly Ser Gln Ser Lys Asp Leu Leu 
                325                 330                 335     


Arg Gln Gly Ser Lys Phe Arg Arg Asn Val Ser Thr Leu Leu Ile Glu 
            340                 345                 350         


Leu Gly Phe Gln Ile Lys Lys Lys Thr Lys Arg Leu Tyr Ile Asn Lys 
        355                 360                 365             


Ala Asn Ile Trp Asn Ser Ala Leu Asp Ala Phe Arg Asn Arg Asn Phe 
    370                 375                 380                 


Asn Pro Ser Tyr Ala Ile Glu Val Ala Tyr Val Ile Glu Asn Asp Asn 
385                 390                 395                 400 


Phe Gly Ser Glu His Pro Gly Ser Lys Gln Glu Phe Leu Ser Leu Leu 
                405                 410                 415     


Met Gln His Leu Glu Asn Ser Ser Leu Phe Glu Gly Ser Leu Ser Lys 
            420                 425                 430         


Asn Leu Ser Leu Asn Ser Gln Ala Leu Lys Glu Asn Leu Tyr Tyr Glu 
        435                 440                 445             


Ala Gly Lys Met Leu Ala Ile Ser Leu Val His Gly Gly Pro Ser Pro 
    450                 455                 460                 


Gly Phe Phe Ser Lys Thr Leu Phe Asn Cys Leu Val Tyr Gly Pro Glu 
465                 470                 475                 480 


Asn Thr Gln Pro Ile Leu Asp Asp Val Ser Asp Phe Asp Val Ala Gln 
                485                 490                 495     


Ile Ile Ile Arg Ile Asn Thr Ala Thr Thr Val Ala Asp Leu Lys Ser 
            500                 505                 510         


Ile Ile Asn Glu Cys Tyr Asn Tyr Leu Glu Leu Ile Gly Cys Leu Arg 
        515                 520                 525             


Leu Ile Thr Thr Leu Ser Asp Lys Tyr Met Leu Val Lys Asp Ile Leu 
    530                 535                 540                 


Gly Tyr His Val Ile Gln Arg Val His Thr Pro Phe Glu Ser Phe Lys 
545                 550                 555                 560 


Gln Gly Leu Lys Thr Leu Gly Val Leu Glu Lys Ile Gln Ala Tyr Pro 
                565                 570                 575     


Glu Ala Phe Cys Ser Ile Leu Cys His Lys Pro Glu Ser Leu Ser Ala 
            580                 585                 590         


Lys Ile Leu Ser Glu Leu Phe Thr Val His Thr Leu Pro Asp Val Lys 
        595                 600                 605             


Ala Leu Gly Phe Trp Asn Ser Tyr Leu Gln Ala Val Glu Asp Gly Lys 
    610                 615                 620                 


Ser Thr Thr Thr Met Glu Asp Ile Leu Ile Phe Ala Thr Gly Cys Ser 
625                 630                 635                 640 


Ser Ile Pro Pro Ala Gly Phe Lys Pro Thr Pro Ser Ile Glu Cys Leu 
                645                 650                 655     


His Val Asp Phe Pro Val Gly Asn Lys Cys Asn Asn Cys Leu Ala Ile 
            660                 665                 670         


Pro Ile Thr Asn Thr Tyr Lys Glu Phe Gln Glu Asn Met Asp Phe Thr 
        675                 680                 685             


Ile Arg Asn Thr Leu Arg Leu Glu Lys Glu Glu Ser Ser His Tyr Ile 
    690                 695                 700                 


Gly His 
705     


<210>  57
<211>  660
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ser Ser Gly Ile Trp Gln Arg Gly Lys Glu Glu Glu Gly Val Tyr 
1               5                   10                  15      


Gly Phe Leu Ile Glu Asp Ile Arg Lys Glu Val Asn Arg Ala Ser Lys 
            20                  25                  30          


Leu Lys Cys Cys Val Cys Lys Lys Asn Gly Ala Ser Ile Gly Cys Val 
        35                  40                  45              


Ala Pro Arg Cys Lys Arg Ser Tyr His Phe Pro Cys Gly Leu Gln Arg 
    50                  55                  60                  


Glu Cys Ile Phe Gln Phe Thr Gly Asn Phe Ala Ser Phe Cys Trp Asp 
65                  70                  75                  80  


His Arg Pro Val Gln Ile Ile Thr Ser Asn Asn Tyr Arg Glu Ser Leu 
                85                  90                  95      


Pro Cys Thr Ile Cys Leu Glu Phe Ile Glu Pro Ile Pro Ser Tyr Asn 
            100                 105                 110         


Ile Leu Arg Ser Pro Cys Cys Lys Asn Ala Trp Phe His Arg Asp Cys 
        115                 120                 125             


Leu Gln Val Gln Ala Ile Asn Ala Gly Val Phe Phe Phe Arg Cys Thr 
    130                 135                 140                 


Ile Cys Asn Asn Ser Asp Ile Phe Gln Lys Glu Met Leu Arg Met Gly 
145                 150                 155                 160 


Ile His Ile Pro Glu Lys Asp Ala Ser Trp Glu Leu Glu Glu Asn Ala 
                165                 170                 175     


Tyr Gln Glu Leu Leu Gln His Tyr Glu Arg Cys Asp Val Arg Arg Cys 
            180                 185                 190         


Arg Cys Lys Glu Gly Arg Asp Tyr Asn Ala Pro Asp Ser Lys Trp Glu 
        195                 200                 205             


Ile Lys Arg Cys Gln Cys Cys Gly Ser Ser Gly Thr His Leu Ala Cys 
    210                 215                 220                 


Ser Ser Leu Arg Ser Trp Glu Gln Asn Trp Glu Cys Leu Glu Cys Arg 
225                 230                 235                 240 


Gly Ile Ile Tyr Asn Ser Gly Glu Phe Gln Lys Ala Lys Lys His Val 
                245                 250                 255     


Leu Pro Asn Ser Asn Asn Val Gly Ile Thr Asp Cys Leu Leu Glu Glu 
            260                 265                 270         


Ser Ser Pro Lys Leu Pro Arg Gln Ser Pro Gly Ser Gln Ser Lys Asp 
        275                 280                 285             


Leu Leu Arg Gln Gly Ser Lys Phe Arg Arg Asn Val Ser Thr Leu Leu 
    290                 295                 300                 


Ile Glu Leu Gly Phe Gln Ile Lys Lys Lys Thr Lys Arg Leu Tyr Ile 
305                 310                 315                 320 


Asn Lys Ala Asn Ile Trp Asn Ser Ala Leu Asp Ala Phe Arg Asn Arg 
                325                 330                 335     


Asn Phe Asn Pro Ser Tyr Ala Ile Glu Val Ala Tyr Val Ile Glu Asn 
            340                 345                 350         


Asp Asn Phe Gly Ser Glu His Pro Gly Ser Lys Gln Glu Phe Leu Ser 
        355                 360                 365             


Leu Leu Met Gln His Leu Glu Asn Ser Ser Leu Phe Glu Gly Ser Leu 
    370                 375                 380                 


Ser Lys Asn Leu Ser Leu Asn Ser Gln Ala Leu Lys Glu Asn Leu Tyr 
385                 390                 395                 400 


Tyr Glu Ala Gly Lys Met Leu Ala Ile Ser Leu Val His Gly Gly Pro 
                405                 410                 415     


Ser Pro Gly Phe Phe Ser Lys Thr Leu Phe Asn Cys Leu Val Tyr Gly 
            420                 425                 430         


Pro Glu Asn Thr Gln Pro Ile Leu Asp Asp Val Ser Asp Phe Asp Val 
        435                 440                 445             


Ala Gln Ile Ile Ile Arg Ile Asn Thr Ala Thr Thr Val Ala Asp Leu 
    450                 455                 460                 


Lys Ser Ile Ile Asn Glu Cys Tyr Asn Tyr Leu Glu Leu Ile Gly Cys 
465                 470                 475                 480 


Leu Arg Leu Ile Thr Thr Leu Ser Asp Lys Tyr Met Leu Val Lys Asp 
                485                 490                 495     


Ile Leu Gly Tyr His Val Ile Gln Arg Val His Thr Pro Phe Glu Ser 
            500                 505                 510         


Phe Lys Gln Gly Leu Lys Thr Leu Gly Val Leu Glu Lys Ile Gln Ala 
        515                 520                 525             


Tyr Pro Glu Ala Phe Cys Ser Ile Leu Cys His Lys Pro Glu Ser Leu 
    530                 535                 540                 


Ser Ala Lys Ile Leu Ser Glu Leu Phe Thr Val His Thr Leu Pro Asp 
545                 550                 555                 560 


Val Lys Ala Leu Gly Phe Trp Asn Ser Tyr Leu Gln Ala Val Glu Asp 
                565                 570                 575     


Gly Lys Ser Thr Thr Thr Met Glu Asp Ile Leu Ile Phe Ala Thr Gly 
            580                 585                 590         


Cys Ser Ser Ile Pro Pro Ala Gly Phe Lys Pro Thr Pro Ser Ile Glu 
        595                 600                 605             


Cys Leu His Val Asp Phe Pro Val Gly Asn Lys Cys Asn Asn Cys Leu 
    610                 615                 620                 


Ala Ile Pro Ile Thr Asn Thr Tyr Lys Glu Phe Gln Glu Asn Met Asp 
625                 630                 635                 640 


Phe Thr Ile Arg Asn Thr Leu Arg Leu Glu Lys Glu Glu Ser Ser His 
                645                 650                 655     


Tyr Ile Gly His 
            660 


<210>  58
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Asn Glu Ser Lys Pro Gly Asp Ser Gln Asn Leu Ala Cys Val Phe 
1               5                   10                  15      


Cys Arg Lys His Asp Asp Cys Pro Asn Lys Tyr Gly Glu Lys Lys Thr 
            20                  25                  30          


Lys Glu Lys Trp Asn Leu Thr Val His Tyr Tyr Cys Leu Leu Met Ser 
        35                  40                  45              


Ser Gly Ile Trp Gln Arg Gly Lys Glu Glu Glu Gly Val Tyr Gly Phe 
    50                  55                  60                  


Leu Ile Glu Asp Ile Arg Lys Glu Val Asn Arg Ala Ser Lys Leu Lys 
65                  70                  75                  80  


Cys Cys Val Cys Lys Lys Asn Gly Ala Ser Ile Gly Cys Val Ala Pro 
                85                  90                  95      


Arg Cys Lys Arg Ser Tyr His Phe Pro Cys Gly Leu Gln Arg Glu Cys 
            100                 105                 110         


Ile Phe Gln Phe Thr Gly Asn Phe Ala Ser Phe Cys Trp Asp His Arg 
        115                 120                 125             


Pro Val Gln Ile Ile Thr Ser Asn Asn Tyr Arg Glu Ser Leu Pro Cys 
    130                 135                 140                 


Thr Ile Cys Leu Glu Phe Ile Glu Pro Ile Pro Ser Tyr Asn Ile Leu 
145                 150                 155                 160 


Arg Ser Pro Cys Cys Lys Asn Ala Trp Phe His Arg Asp Cys Leu Gln 
                165                 170                 175     


<210>  59
<211>  101
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  59

Xaa Cys Arg Cys Lys Glu Gly Arg Asp Tyr Asn Ala Pro Asp Ser Lys 
1               5                   10                  15      


Trp Glu Ile Lys Arg Cys Gln Cys Cys Gly Ser Ser Gly Thr His Leu 
            20                  25                  30          


Ala Cys Ser Ser Leu Arg Ser Trp Glu Gln Asn Trp Glu Cys Leu Glu 
        35                  40                  45              


Cys Arg Gly Ile Ile Tyr Asn Ser Gly Glu Phe Gln Lys Ala Lys Lys 
    50                  55                  60                  


His Val Leu Pro Asn Ser Asn Asn Val Gly Ile Thr Asp Cys Leu Leu 
65                  70                  75                  80  


Glu Glu Ser Ser Pro Lys Leu Pro Arg Gln Ser Pro Gly Ser Gln Ser 
                85                  90                  95      


Lys Asp Leu Leu Arg 
            100     


<210>  60
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Asn Glu Ser Lys Pro Gly Asp Ser Gln Asn Leu Ala Cys Val Phe 
1               5                   10                  15      


Cys Arg Lys His Asp Asp Cys Pro Asn Lys Tyr Gly Glu Lys Lys Thr 
            20                  25                  30          


Lys Glu Lys Trp Asn Leu Thr Val His Tyr Tyr Cys Leu Leu Met Ser 
        35                  40                  45              


Ser Gly Ile Trp Gln Arg Gly Lys Glu Glu Glu Gly Val Tyr Gly Phe 
    50                  55                  60                  


Leu Ile Glu Asp Ile Arg Lys Glu Val Asn Arg Ala Ser Lys Leu Lys 
65                  70                  75                  80  


Cys Cys Val Cys Lys Lys Asn Gly Ala Ser Ile Gly Cys Val Ala Pro 
                85                  90                  95      


Arg Cys Lys Arg Ser Tyr His Phe Pro Cys Gly Leu Gln Arg Glu Cys 
            100                 105                 110         


Ile Phe Gln Phe Thr Gly Asn Phe Ala Ser Phe Cys Trp Asp His Arg 
        115                 120                 125             


Pro Val Gln Ile Ile Thr Ser Asn Asn Tyr Arg Glu Ser Leu Pro Cys 
    130                 135                 140                 


Thr Ile Cys Leu Glu Phe Ile Glu Pro Ile Pro Ser Tyr Asn Ile Leu 
145                 150                 155                 160 


Arg Ser Pro Cys Cys Lys Asn Ala Trp Phe His Arg Asp Cys Leu Gln 
                165                 170                 175     


Val Gln Ala Ile Asn Ala Gly Val Phe Phe Phe Arg Cys Thr Ile Cys 
            180                 185                 190         


Asn Asn Ser Asp Ile Phe Gln Lys Glu Met Leu Arg Met Gly Ile His 
        195                 200                 205             


Ile Pro Glu Lys Asp Ala Ser Trp Glu Leu Glu Glu Asn Ala Tyr Gln 
    210                 215                 220                 


Glu Leu Leu Gln His Tyr Glu Arg Cys Asp Val Arg Arg Cys Arg Cys 
225                 230                 235                 240 


Lys Glu Gly Arg Asp Tyr Asn Ala Pro Asp Ser Lys Trp Glu Ile Lys 
                245                 250                 255     


Arg Cys Gln Cys Cys Gly Ser Ser Gly Thr His Leu Ala Cys Ser Ser 
            260                 265                 270         


Leu Arg Ser Trp Glu Gln Asn Trp Glu Cys Leu Glu Cys Arg Gly Ile 
        275                 280                 285             


Ile Tyr Asn Ser Gly Glu Phe Gln Lys Ala Lys Lys His Val Leu Pro 
    290                 295                 300                 


Asn Ser Asn Asn Val Gly Ile Thr Asp Cys Leu Leu Glu Glu Ser Ser 
305                 310                 315                 320 


Pro Lys Leu Pro Arg Gln Ser Pro Gly Ser Gln Ser Lys Asp Leu Leu 
                325                 330                 335     


Arg Asn Lys Val Ser Leu Cys Tyr Pro Gly Trp Ser Thr Val Ala 
            340                 345                 350     


<210>  61
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Asn Glu Ser Lys Pro Gly Asp Ser Gln Asn Leu Ala Cys Val Phe 
1               5                   10                  15      


Cys Arg Lys His Asp Asp Cys Pro Asn Lys Tyr Gly Glu Lys Lys Thr 
            20                  25                  30          


Lys Glu Lys Trp Asn Leu Thr Val His Tyr Tyr Cys Leu Leu Met Ser 
        35                  40                  45              


Ser Gly Ile Trp Gln Arg Gly Lys Glu Glu Glu Gly Val Tyr Gly Phe 
    50                  55                  60                  


Leu Ile Glu Asp Ile Arg Lys Glu Val Asn Arg Ala Ser Lys Leu Lys 
65                  70                  75                  80  


Cys Cys Val Cys Lys Lys Asn Gly Ala Ser Ile Gly Cys Val Ala Pro 
                85                  90                  95      


Arg Cys Lys Arg Ser Tyr His Phe Pro Cys Gly Leu Gln Arg Glu Cys 
            100                 105                 110         


Ile Phe Gln Phe Thr Gly Asn Phe Ala 
        115                 120     


<210>  62
<211>  736
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Leu Ile Pro Ala Leu Gln Ile Ser Asp Ser Glu Ser Val Gly Leu 
1               5                   10                  15      


Glu Asp Gly Ile Glu Gln Ser Ala Tyr Leu Thr Glu Ser Lys Met Asn 
            20                  25                  30          


Glu Ser Lys Pro Gly Asp Ser Gln Asn Leu Ala Cys Val Phe Cys Arg 
        35                  40                  45              


Lys His Asp Asp Cys Pro Asn Lys Tyr Gly Glu Lys Lys Thr Lys Glu 
    50                  55                  60                  


Lys Trp Asn Leu Thr Val His Tyr Tyr Cys Leu Leu Met Ser Ser Gly 
65                  70                  75                  80  


Ile Trp Gln Arg Gly Lys Glu Glu Glu Gly Val Tyr Gly Phe Leu Ile 
                85                  90                  95      


Glu Asp Ile Arg Lys Glu Val Asn Arg Ala Ser Lys Leu Lys Cys Cys 
            100                 105                 110         


Val Cys Lys Lys Asn Gly Ala Ser Ile Gly Cys Val Ala Pro Arg Cys 
        115                 120                 125             


Lys Arg Ser Tyr His Phe Pro Cys Gly Leu Gln Arg Glu Cys Ile Phe 
    130                 135                 140                 


Gln Phe Thr Gly Asn Phe Ala Ser Phe Cys Trp Asp His Arg Pro Val 
145                 150                 155                 160 


Gln Ile Ile Thr Ser Asn Asn Tyr Arg Glu Ser Leu Pro Cys Thr Ile 
                165                 170                 175     


Cys Leu Glu Phe Ile Glu Pro Ile Pro Ser Tyr Asn Ile Leu Arg Ser 
            180                 185                 190         


Pro Cys Cys Lys Asn Ala Trp Phe His Arg Asp Cys Leu Gln Val Gln 
        195                 200                 205             


Ala Ile Asn Ala Gly Val Phe Phe Phe Arg Cys Thr Ile Cys Asn Asn 
    210                 215                 220                 


Ser Asp Ile Phe Gln Lys Glu Met Leu Arg Met Gly Ile His Ile Pro 
225                 230                 235                 240 


Glu Lys Asp Ala Ser Trp Glu Leu Glu Glu Asn Ala Tyr Gln Glu Leu 
                245                 250                 255     


Leu Gln His Tyr Glu Arg Cys Asp Val Arg Arg Cys Arg Cys Lys Glu 
            260                 265                 270         


Gly Arg Asp Tyr Asn Ala Pro Asp Ser Lys Trp Glu Ile Lys Arg Cys 
        275                 280                 285             


Gln Cys Cys Gly Ser Ser Gly Thr His Leu Ala Cys Ser Ser Leu Arg 
    290                 295                 300                 


Ser Trp Glu Gln Asn Trp Glu Cys Leu Glu Cys Arg Gly Ile Ile Tyr 
305                 310                 315                 320 


Asn Ser Gly Glu Phe Gln Lys Ala Lys Lys His Val Leu Pro Asn Ser 
                325                 330                 335     


Asn Asn Val Gly Ile Thr Asp Cys Leu Leu Glu Glu Ser Ser Pro Lys 
            340                 345                 350         


Leu Pro Arg Gln Ser Pro Gly Ser Gln Ser Lys Asp Leu Leu Arg Gln 
        355                 360                 365             


Gly Ser Lys Phe Arg Arg Asn Val Ser Thr Leu Leu Ile Glu Leu Gly 
    370                 375                 380                 


Phe Gln Ile Lys Lys Lys Thr Lys Arg Leu Tyr Ile Asn Lys Ala Asn 
385                 390                 395                 400 


Ile Trp Asn Ser Ala Leu Asp Ala Phe Arg Asn Arg Asn Phe Asn Pro 
                405                 410                 415     


Ser Tyr Ala Ile Glu Val Ala Tyr Val Ile Glu Asn Asp Asn Phe Gly 
            420                 425                 430         


Ser Glu His Pro Gly Ser Lys Gln Glu Phe Leu Ser Leu Leu Met Gln 
        435                 440                 445             


His Leu Glu Asn Ser Ser Leu Phe Glu Gly Ser Leu Ser Lys Asn Leu 
    450                 455                 460                 


Ser Leu Asn Ser Gln Ala Leu Lys Glu Asn Leu Tyr Tyr Glu Ala Gly 
465                 470                 475                 480 


Lys Met Leu Ala Ile Ser Leu Val His Gly Gly Pro Ser Pro Gly Phe 
                485                 490                 495     


Phe Ser Lys Thr Leu Phe Asn Cys Leu Val Tyr Gly Pro Glu Asn Thr 
            500                 505                 510         


Gln Pro Ile Leu Asp Asp Val Ser Asp Phe Asp Val Ala Gln Ile Ile 
        515                 520                 525             


Ile Arg Ile Asn Thr Ala Thr Thr Val Ala Asp Leu Lys Ser Ile Ile 
    530                 535                 540                 


Asn Glu Cys Tyr Asn Tyr Leu Glu Leu Ile Gly Cys Leu Arg Leu Ile 
545                 550                 555                 560 


Thr Thr Leu Ser Asp Lys Tyr Met Leu Val Lys Asp Ile Leu Gly Tyr 
                565                 570                 575     


His Val Ile Gln Arg Val His Thr Pro Phe Glu Ser Phe Lys Gln Gly 
            580                 585                 590         


Leu Lys Thr Leu Gly Val Leu Glu Lys Ile Gln Ala Tyr Pro Glu Ala 
        595                 600                 605             


Phe Cys Ser Ile Leu Cys His Lys Pro Glu Ser Leu Ser Ala Lys Ile 
    610                 615                 620                 


Leu Ser Glu Leu Phe Thr Val His Thr Leu Pro Asp Val Lys Ala Leu 
625                 630                 635                 640 


Gly Phe Trp Asn Ser Tyr Leu Gln Ala Val Glu Asp Gly Lys Ser Thr 
                645                 650                 655     


Thr Thr Met Glu Asp Ile Leu Ile Phe Ala Thr Gly Cys Ser Ser Ile 
            660                 665                 670         


Pro Pro Ala Gly Phe Lys Pro Thr Pro Ser Ile Glu Cys Leu His Val 
        675                 680                 685             


Asp Phe Pro Val Gly Asn Lys Cys Asn Asn Cys Leu Ala Ile Pro Ile 
    690                 695                 700                 


Thr Asn Thr Tyr Lys Glu Phe Gln Glu Asn Met Asp Phe Thr Ile Arg 
705                 710                 715                 720 


Asn Thr Leu Arg Leu Glu Lys Glu Glu Ser Ser His Tyr Ile Gly His 
                725                 730                 735     


<210>  63
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Asn Glu Ser Lys Pro Gly Asp Ser Gln Asn Leu Ala Cys Val Phe 
1               5                   10                  15      


Cys Arg Lys His Asp Asp Cys Pro Asn Lys Tyr Gly Glu Lys Lys Thr 
            20                  25                  30          


Lys Glu Lys Trp Asn Leu Thr Val His Tyr Tyr Cys Leu Leu Met Ser 
        35                  40                  45              


Ser Gly Ile Trp Gln Arg Gly Lys Glu Glu Glu Gly Val Tyr Gly Phe 
    50                  55                  60                  


Leu Ile Glu Asp Ile Arg Lys Glu Val Asn Arg Ala Ser Lys Leu Lys 
65                  70                  75                  80  


Cys Cys Val Cys Lys Lys Asn Gly Ala Ser Ile Gly Cys Val Ala Pro 
                85                  90                  95      


Arg Cys Lys Arg Ser Tyr His Phe Pro Cys Gly Leu Gln Arg Glu Cys 
            100                 105                 110         


Ile Phe Gln Phe Thr Gly Asn Phe Ala Ser Phe Cys Trp Asp His Arg 
        115                 120                 125             


Pro Val Gln 
    130     


<210>  64
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Asn Glu Ser Lys Pro Gly Asp Ser Gln Asn Leu Ala Cys Val Phe 
1               5                   10                  15      


Cys Arg Lys His Asp Asp Cys Pro Asn Lys Tyr Gly Glu Lys Lys Thr 
            20                  25                  30          


Lys Glu Lys Trp Asn Leu Thr Val His Tyr Tyr Cys Leu Leu Met Ser 
        35                  40                  45              


Ser Gly Ile Trp Gln Arg Gly Lys Glu Glu Glu Gly Val Tyr Gly Phe 
    50                  55                  60                  


Leu Ile Glu Asp Ile Arg Lys Glu Val Asn Arg Ala Ser Lys Leu 
65                  70                  75                  


<210>  65
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  65

Xaa Glu Val Leu Val Val Arg Thr Leu Gly Phe Ile Glu Thr Val Tyr 
1               5                   10                  15      


Ser Lys Trp Glu Ile Lys Arg Cys Gln Cys Cys Gly Ser Ser Gly Thr 
            20                  25                  30          


His Leu Ala Cys Ser Ser Leu Arg Ser Trp Glu Gln Asn Trp Glu Cys 
        35                  40                  45              


Leu Glu Cys Arg Gly Ile Ile Tyr Asn Ser Gly Glu Phe Gln Lys Ala 
    50                  55                  60                  


Lys Lys His Val Leu Pro Asn Ser Asn Asn Val Gly Ile Thr Asp Cys 
65                  70                  75                  80  


Leu Leu Glu Glu Ser Ser Pro Lys Leu Pro Arg Gln Ser Pro Gly Ser 
                85                  90                  95      


Gln Ser Lys Asp Leu Leu Arg Gln Gly Ser Lys Phe Arg Arg Asn Val 
            100                 105                 110         


Ser Thr Leu Leu Ile Glu Leu Gly Phe Gln Ile 
        115                 120             


<210>  66
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Lys Phe Pro Ala Ser Val Leu Ala Ser Val Phe Leu Phe Val Ala 
1               5                   10                  15      


Glu Thr Thr Ala Ala Leu Ser Leu Ser Ser Thr Tyr Arg Ser Gly Gly 
            20                  25                  30          


Asp Arg Met Trp Gln Ala Leu Thr Leu Leu Phe Ser Leu Leu Pro Cys 
        35                  40                  45              


Ala Leu Val Gln Leu Thr Leu Leu Phe Val His Arg Asp Leu Ser Arg 
    50                  55                  60                  


Asp Arg Pro Leu Val Leu Leu Leu His Leu Leu Gln Leu Gly Pro Leu 
65                  70                  75                  80  


Phe Arg Cys Phe Glu Val Phe Cys Ile Tyr Phe Gln Ser Gly Asn Asn 
                85                  90                  95      


Glu Glu Pro Tyr Val Ser Ile Thr Lys Lys Arg Gln Met Pro Lys Asn 
            100                 105                 110         


Gly Leu Ser Glu Glu Ile Glu Lys Glu Val Gly Gln Ala Glu Gly Lys 
        115                 120                 125             


Leu Ile Thr His Arg Ser Ala Phe Ser Arg Ala Ser Val Ile Gln Ala 
    130                 135                 140                 


Phe Leu Gly Ser Ala Pro Gln Leu Thr Leu Gln Leu Tyr Ile Ser Val 
145                 150                 155                 160 


Met Gln Gln Asp Val Thr Val Gly Arg Ser Leu Leu Met Thr Ile Ser 
                165                 170                 175     


Leu Leu Ser Ile Val Tyr Gly Ala Leu Arg Cys Asn Ile Leu Ala Ile 
            180                 185                 190         


Lys Ile Lys Tyr Asp Glu Tyr Glu Val Lys Val Lys Pro Leu Ala Tyr 
        195                 200                 205             


Val Cys Ile Phe Leu Trp Arg Ser Phe Glu Ile Ala Thr Arg Val Val 
    210                 215                 220                 


Val Leu Val Leu Phe Thr Ser Val Leu Lys Thr Trp Val Val Val Ile 
225                 230                 235                 240 


Ile Leu Ile Asn Phe Phe Ser Phe Phe Leu Tyr Pro Trp Ile Leu Phe 
                245                 250                 255     


Trp Cys Ser Gly Ser Pro Phe Pro Glu Asn Ile Glu Lys Ala Leu Ser 
            260                 265                 270         


Arg Val Gly Thr Thr Ile Val Leu Cys Phe Leu Thr Leu Leu Tyr Thr 
        275                 280                 285             


Gly Ile Asn Met Phe Cys Trp Ser Ala Val Gln Leu Lys Ile Asp Ser 
    290                 295                 300                 


Pro Asp Leu Ile Ser Lys Ser His Asn Trp Tyr Gln Leu Leu Val Tyr 
305                 310                 315                 320 


Tyr Met Ile Arg Phe Ile Glu Asn Ala Ile Leu Leu Leu Leu Trp Tyr 
                325                 330                 335     


Leu Phe Lys Thr Asp Ile Tyr Met Tyr Val Cys Ala Pro Leu Leu Val 
            340                 345                 350         


Leu Gln Leu Leu Ile Gly Tyr Cys Thr Ala Ile Leu Phe Met Leu Val 
        355                 360                 365             


Phe Tyr Gln Phe Phe His Pro Cys Lys Lys Leu Phe Ser Ser Ser Val 
    370                 375                 380                 


Ser Glu Gly Phe Gln Arg Trp Leu Arg Cys Phe Cys Trp Ala Cys Arg 
385                 390                 395                 400 


Gln Gln Lys Pro Cys Glu Pro Ile Gly Lys Glu Asp Leu Gln Ser Ser 
                405                 410                 415     


Arg Asp Arg Asp Glu Thr Pro Ser Ser Ser Lys Thr Ser Pro Glu Pro 
            420                 425                 430         


Gly Gln Phe Leu Asn Ala Glu Asp Leu Cys Ser Ala 
        435                 440                 


<210>  67
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Leu Cys Tyr Val Thr Arg Pro Asp Ala Val Leu Met Glu Val Glu 
1               5                   10                  15      


Val Glu Ala Lys Ala Asn Gly Glu Asp Cys Leu Asn Gln Val Cys Arg 
            20                  25                  30          


Arg Leu Gly Ile Ile Glu Val Asp Tyr Phe Gly Leu Gln Phe Thr Gly 
        35                  40                  45              


Ser Lys Gly Glu Ser Leu Trp Leu Asn Leu Arg Asn Arg Ile Ser Gln 
    50                  55                  60                  


Gln Met Asp Gly Leu Ala Pro Tyr Arg Leu Lys Leu Arg Val Lys Phe 
65                  70                  75                  80  


Phe Val Glu Pro His Leu Ile Leu Gln Glu Gln Thr Arg His Ile Phe 
                85                  90                  95      


Phe Leu His Ile Lys Glu Ala Leu Leu Ala Gly His Leu Leu Cys Ser 
            100                 105                 110         


Pro Glu Gln Ala Val Glu Leu Ser Ala Leu Leu Ala Gln Thr Lys Phe 
        115                 120                 125             


Gly Asp Tyr Asn Gln Asn Thr Ala Lys Tyr Asn Tyr Glu Glu Leu Cys 
    130                 135                 140                 


Ala Lys Glu Leu Ser Ser Ala Thr Leu Asn Ser Ile Val Ala Lys His 
145                 150                 155                 160 


Lys Glu Leu Glu Gly Thr Ser Gln Ala Ser Ala Glu Tyr Gln Val Leu 
                165                 170                 175     


Gln Ile Val Ser Ala Met Glu Asn Tyr Gly Ile Glu Trp His Ser Val 
            180                 185                 190         


Arg Asp Ser Glu Gly Gln Lys Leu Leu Ile Gly Val Gly Pro Glu Gly 
        195                 200                 205             


Ile Ser Ile Cys Lys Asp Asp Phe Ser Pro Ile Asn Arg Ile Ala Tyr 
    210                 215                 220                 


Pro Val Val Gln Met Ala Thr Gln Ser Gly Lys Asn Val Tyr Leu Thr 
225                 230                 235                 240 


Val Thr Lys Glu Ser Gly Asn Ser Ile Val Leu Leu Phe Lys Met Ile 
                245                 250                 255     


Ser Thr Arg Ala Ala Ser Gly Leu Tyr Arg Ala Ile Thr Glu Thr His 
            260                 265                 270         


Ala Phe Tyr Arg Cys Asp Thr Val Thr Ser Ala Val Met Met Gln Tyr 
        275                 280                 285             


Ser Arg Asp Leu Lys Gly His Leu Ala Ser Leu Phe Leu Asn Glu Asn 
    290                 295                 300                 


Ile Asn Leu Gly Lys Lys Tyr Val Phe Asp Ile Lys Arg Thr Ser Lys 
305                 310                 315                 320 


Glu Val Tyr Asp His Ala Arg Arg Ala Leu Tyr Asn Ala Gly Val Val 
                325                 330                 335     


Asp Leu Val Ser Arg Asn Asn Gln Ser Pro Ser His Ser Pro Leu Lys 
            340                 345                 350         


Ser Ser Glu Ser Ser Met Asn Cys Ser Ser Cys Glu Gly Leu Ser Cys 
        355                 360                 365             


Gln Gln Thr Arg Val Leu Gln Glu Lys Leu Arg Lys Leu Lys Glu Ala 
    370                 375                 380                 


Met Leu Cys Met Val Cys Cys Glu Glu Glu Ile Asn Ser Thr Phe Cys 
385                 390                 395                 400 


Pro Cys Gly His Thr Val Cys Cys Glu Ser Cys Ala Ala Gln Leu Gln 
                405                 410                 415     


Ser Cys Pro Val Cys Arg Ser Arg Val Glu His Val Gln His Val Tyr 
            420                 425                 430         


Leu Pro Thr His Thr Ser Leu Leu Asn Leu Thr Val Ile 
        435                 440                 445 


<210>  68
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Glu Asn Tyr Gly Ile Glu Trp His Ser Val Arg Asp Ser Glu Gly 
1               5                   10                  15      


Gln Lys Leu Leu Ile Gly Val Gly Pro Glu Gly Ile Ser Ile Cys Lys 
            20                  25                  30          


Asp Asp Phe Ser Pro Ile Asn Arg Ile Ala Tyr Pro Val Val Gln Met 
        35                  40                  45              


Ala Thr Gln Ser Gly Lys Asn Val Tyr Leu Thr Val Thr Lys Glu Ser 
    50                  55                  60                  


Gly Asn Ser Ile Val Leu Leu Phe Lys Met Ile Ser Thr Arg Ala Ala 
65                  70                  75                  80  


Ser Gly Leu Tyr Arg Ala Ile Thr Glu Thr His Ala Phe Tyr Arg Cys 
                85                  90                  95      


Asp Thr Val Thr Ser Ala Val Met Met Gln Tyr Ser Arg Asp Leu Lys 
            100                 105                 110         


Gly His Leu Ala Ser Leu Phe Leu Asn Glu Asn Ile Asn Leu Gly Lys 
        115                 120                 125             


Lys Tyr Val Phe Asp Ile Lys Arg Thr Ser Lys Glu Val Tyr Asp His 
    130                 135                 140                 


Ala Arg Arg Ala Leu Tyr Asn Ala Gly Val Val Asp Leu Val Ser Arg 
145                 150                 155                 160 


Asn Asn Gln Ser Pro Ser His Ser Pro Leu Lys Ser Ser Glu Ser Ser 
                165                 170                 175     


Met Asn Cys Ser Ser Cys Glu Gly Leu Ser Cys Gln Gln Thr Arg Val 
            180                 185                 190         


Leu Gln Glu Lys Leu Arg Lys Leu Lys Glu Ala Met Leu Cys Met Val 
        195                 200                 205             


Cys Cys Glu Glu Glu Ile Asn Ser Thr Phe Cys Pro Cys Gly His Thr 
    210                 215                 220                 


Val Cys Cys Glu Ser Cys Ala Ala Gln Leu Gln Ser Cys Pro Val Cys 
225                 230                 235                 240 


Arg Ser Arg Val Glu His Val Gln His Val Tyr Leu Pro Thr His Thr 
                245                 250                 255     


Ser Leu Leu Asn Leu Thr Val Ile 
            260                 


<210>  69
<211>  749
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Ala Leu Pro Leu Leu Pro Gly Asn Ser Phe Asn Arg Asn Val Gly 
1               5                   10                  15      


Lys Glu Lys Phe His Lys Ser Gln His Trp Gly Phe Cys Asn Asn Val 
            20                  25                  30          


Met Met Leu Val Ser Asp Glu Lys Pro Gly Ile Gly Gly Glu Pro Leu 
        35                  40                  45              


Leu Gly Gln Lys Ile Lys Pro Lys Cys Ser Ile Tyr Pro Lys Gly Asp 
    50                  55                  60                  


Gly Ser Asp Val Pro Ser Trp Val Ala Phe Asp Lys Gln Val Leu Ser 
65                  70                  75                  80  


Phe Asp Ala Tyr Leu Glu Glu Glu Val Leu Asp Lys Ser Gln Thr Asn 
                85                  90                  95      


Tyr Arg Ile Arg Tyr Tyr Lys Ile Tyr Phe Tyr Pro Glu Asp Asp Thr 
            100                 105                 110         


Ile Gln Val Asn Glu Pro Glu Val Lys Asn Ser Gly Leu Leu Gln Gly 
        115                 120                 125             


Thr Ser Ile Arg Arg His Arg Ile Thr Leu Pro Pro Pro Asp Glu Asp 
    130                 135                 140                 


Gln Phe Tyr Thr Val Tyr His Phe Asn Val Gly Thr Glu Val Val Phe 
145                 150                 155                 160 


Tyr Gly Arg Thr Phe Lys Ile Tyr Asp Cys Asp Ala Phe Thr Arg Asn 
                165                 170                 175     


Phe Leu Arg Lys Ile Gly Val Lys Val Asn Pro Pro Val Gln Cys Pro 
            180                 185                 190         


Glu Asp Pro Tyr Met Lys Ile Arg Arg Glu Val Val Glu His Val Glu 
        195                 200                 205             


Pro Leu Arg Pro Tyr Glu Ser Leu Asp Thr Leu Lys Gln Phe Leu Gln 
    210                 215                 220                 


Tyr His Gly Lys Ile Leu Cys Phe Phe Cys Leu Trp Asp Asp Ser Val 
225                 230                 235                 240 


Ser Met Phe Gly Asp Arg Arg Glu Leu Ile Leu His Tyr Phe Leu Cys 
                245                 250                 255     


Asp Asp Thr Ile Glu Ile Lys Glu Leu Leu Pro His Ser Ser Gly Arg 
            260                 265                 270         


Asp Ala Leu Lys Met Phe Leu Arg Arg Ser Lys Leu Pro Lys Asn Cys 
        275                 280                 285             


Pro Pro Arg Val Tyr Gln Pro Gly Gln Ile Thr Asp Arg Ala Val Leu 
    290                 295                 300                 


Asn Ser Tyr Gly Asp Phe Ile Lys Asn Gln Ala Asp Gly Tyr Leu Phe 
305                 310                 315                 320 


Asp Arg Tyr Lys Leu Gly Lys Val Asp Gln Glu Phe Tyr Lys Asp Ser 
                325                 330                 335     


Asp Leu Ser Leu Gly Val Thr Ile Asn Val Trp Gly Arg Lys Val Leu 
            340                 345                 350         


Leu Tyr Asp Cys Asp Glu Phe Thr Lys Ser Tyr Tyr Lys Ser Lys Tyr 
        355                 360                 365             


Gly Ile Glu Asn Phe Thr Ser Val Ser Cys Lys Pro Pro Ser Pro Pro 
    370                 375                 380                 


Pro Lys Ile Glu Arg Lys Phe Pro Pro Tyr Asn Gly Phe Gly Ser Glu 
385                 390                 395                 400 


Glu Asp Ser Leu Arg Asn Cys Ile Asp Leu Lys Pro Thr Pro His Arg 
                405                 410                 415     


Arg Asn Phe Lys Lys Phe Met Glu Lys Asp Ser Tyr Gly Ser Lys Ser 
            420                 425                 430         


Asn Ile Leu Arg Phe Phe Ala Lys Leu Val Thr Asp Lys Cys Val Asp 
        435                 440                 445             


Leu Asp Arg Met Phe Val Ile Ser Tyr Tyr Leu Gly Asp Asp Thr Ile 
    450                 455                 460                 


Ser Val Phe Glu Pro Ile Glu Arg Asn Ser Gly Ile Ala Gly Gly Met 
465                 470                 475                 480 


Phe Leu Lys Arg Ser Arg Val Lys Lys Pro Gly Gln Glu Val Phe Lys 
                485                 490                 495     


Ser Glu Leu Ser Glu Tyr Ile Lys Ala Glu Glu Leu Tyr Ile Gly Val 
            500                 505                 510         


Thr Val Asn Val Asn Gly Tyr Leu Phe Arg Leu Leu Asn Ala Asp Glu 
        515                 520                 525             


Tyr Thr Leu Asn Tyr Met Glu Gln Asn Thr Asp Lys Tyr Pro Phe Ser 
    530                 535                 540                 


Asn Leu Lys Leu Ala Leu Gln Lys Leu Lys Gln Glu Glu Gly Lys Ser 
545                 550                 555                 560 


Arg Glu Leu Lys Gln Val Phe Lys Ala Ala Asp Ser Lys His Thr Asn 
                565                 570                 575     


Met Val Asp Tyr Asn Thr Phe Arg Asp Ile Leu Met Ser Leu Thr Val 
            580                 585                 590         


Gly Asn Leu Ala Glu Gln Glu Phe Val Thr Ile Ala Arg His Tyr Arg 
        595                 600                 605             


Val Pro Glu Gly Thr Cys Ser Asp Met Asp Phe Leu Ile Ala Leu Ala 
    610                 615                 620                 


His Glu Lys Phe Lys Lys Asn Met Phe Glu Asn Phe Asp Thr Phe Ile 
625                 630                 635                 640 


Tyr Ser Cys Val Tyr Glu Asp Arg Glu Lys Lys Asn Val Leu Pro Thr 
                645                 650                 655     


Lys Asp Ile Lys Arg Leu Cys Lys Ser Ser Arg Leu Pro Leu Ser Asp 
            660                 665                 670         


Asp Leu Leu Glu Ser Leu Leu Ser Arg Phe Glu Asp Ser Glu Lys Gln 
        675                 680                 685             


Ile Asp Tyr Lys Ser Phe Phe Ser Ala Leu Asn Trp Arg Lys Asn Pro 
    690                 695                 700                 


Val Pro Glu Leu Gln Pro Ala Ser Tyr Leu Lys Glu Arg Cys Glu Asp 
705                 710                 715                 720 


Val Trp Leu Gly Met Pro Ser Pro Ile Pro Ala Lys Tyr Ile Asp Tyr 
                725                 730                 735     


Trp Thr Phe Leu Lys Asp Ala Phe Gly Leu Glu Glu Glu 
            740                 745                 


<210>  70
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Gly Arg Thr Ser Lys Asp Lys Arg Asp Val Tyr Tyr Arg Leu Ala 
1               5                   10                  15      


Lys Glu Asn Gly Trp Arg Ala Arg Ser Ala Phe Lys Leu Leu Gln Leu 
            20                  25                  30          


Asp Lys Glu Phe Gln Leu Phe Gln Gly Val Thr Arg Ala Val Asp Leu 
        35                  40                  45              


Cys Ala Ala Pro Gly Ser Trp Ser Gln Val Leu Ser Gln Lys Ile Gly 
    50                  55                  60                  


Gly Gln Gly Ser Gly His Val Val Ala Val Asp Leu Gln Ala Met Ala 
65                  70                  75                  80  


Pro Leu Pro Gly Val Val Gln Ile Gln Gly Asp Ile Thr Gln Leu Ser 
                85                  90                  95      


Thr Ala Lys Glu Ile Ile Gln His Phe Lys Gly Cys Pro Ala Asp Leu 
            100                 105                 110         


Val Val Cys Asp Gly Ala Pro Asp Val Thr Gly Leu His Asp Val Asp 
        115                 120                 125             


Glu Tyr Met Gln Ala Gln Leu Leu Leu Ala Ala Leu Asn Ile Ala Thr 
    130                 135                 140                 


His Val Leu Lys Pro Gly Gly Cys Phe Val Ala Lys Ile Phe Arg Gly 
145                 150                 155                 160 


Arg Asp Val Thr Leu Leu Tyr Ser Gln Leu Gln Val Phe Phe Ser Ser 
                165                 170                 175     


Val Leu Cys Ala Lys Pro Arg Ser Ser Arg Asn Ser Ser Ile Glu Ala 
            180                 185                 190         


Phe Ala Val Cys Gln Gly Tyr Asp Pro Pro Glu Gly Phe Ile Pro Asp 
        195                 200                 205             


Leu Ser Lys Pro Leu Leu Asp His Ser Tyr Asp Phe Asn Gln Leu Asp 
    210                 215                 220                 


Gly Pro Thr Arg Ile Ile Val Pro Phe Val Thr Cys Gly Asp Leu Ser 
225                 230                 235                 240 


Ser Tyr Asp Ser Asp Arg Ser Tyr Pro Leu Asp Leu Glu Gly Gly Ser 
                245                 250                 255     


Glu Tyr Lys Tyr Thr Pro Pro Thr Gln Pro Pro Ile Ser Pro Pro Tyr 
            260                 265                 270         


Gln Glu Ala Cys Thr Leu Lys Arg Lys Gly Gln Leu Ala Lys Glu Ile 
        275                 280                 285             


Arg Pro Gln Asp Cys Pro Ile Ser Arg Val Asp Thr Phe Pro Gln Pro 
    290                 295                 300                 


Leu Ala Ala Pro Gln Cys His Thr Leu Leu Ala Pro Glu Met Glu Asp 
305                 310                 315                 320 


Asn Glu Met Ser Cys Ser Pro 
                325         


<210>  71
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Gly Arg Thr Ser Lys Asp Lys Arg Asp Val Tyr Tyr Arg Leu Ala 
1               5                   10                  15      


Lys Glu Asn Gly Trp Arg Ala Arg Ser Ala Phe Lys Leu Leu Gln Leu 
            20                  25                  30          


Asp Lys Glu Phe Gln Leu Phe Gln Gly Val Thr Arg Ala Val Asp Leu 
        35                  40                  45              


Cys Ala Ala Pro Gly Ser Trp Ser Gln Val Leu Ser Gln Lys Ile Gly 
    50                  55                  60                  


Gly Gln Gly Ser Gly His Val Val Ala Val Asp Leu Gln Ala Met Ala 
65                  70                  75                  80  


Pro Leu Pro Gly Val Val Gln Ile Gln Gly Asp Ile Thr Gln Leu Ser 
                85                  90                  95      


Thr Ala Lys Glu Ile Ile Gln His Phe Lys Gly Cys Pro Ala Asp Leu 
            100                 105                 110         


Val Val Cys Asp Gly Ala Pro Asp Val Thr Gly Leu His Asp Val Asp 
        115                 120                 125             


Glu Tyr Met Gln Ala Gln Leu Leu Leu Ala Ala Leu Asn Ile Ala Thr 
    130                 135                 140                 


His Val Leu Lys Pro Gly Gly Cys Phe Val Ala Lys Ile Phe Arg Gly 
145                 150                 155                 160 


Arg Asp Val Thr Leu Leu Tyr Ser Gln Leu Gln Val Phe Phe Ser Ser 
                165                 170                 175     


Val Leu Cys Ala Lys Pro Arg Ser Ser Arg Asn Ser Ser Ile Glu Ala 
            180                 185                 190         


Phe Ala Val Cys Gln Gly Tyr Asp Pro Pro Glu Gly Phe Ile Pro Asp 
        195                 200                 205             


Leu Ser Lys Pro Leu Leu Asp His Ser Tyr Asp Pro Asp Phe Asn Gln 
    210                 215                 220                 


Leu Asp Gly Pro Thr Arg Ile Ile Val Pro Phe Val Thr Cys Gly Asp 
225                 230                 235                 240 


Leu Ser Ser Tyr Asp Ser Asp Arg Ser Tyr Pro Leu Asp Leu Glu Gly 
                245                 250                 255     


Gly Ser Glu Tyr Lys Tyr Thr Pro Pro Thr Gln Pro Pro Ile Ser Pro 
            260                 265                 270         


Pro Tyr Gln Glu Ala Cys Thr Leu Lys Arg Lys Gly Gln Leu Ala Lys 
        275                 280                 285             


Glu Ile Arg Pro Gln Asp Cys Pro Ile Ser Arg Val Asp Thr Phe Pro 
    290                 295                 300                 


Gln Pro Leu Ala Ala Pro Gln Cys His Thr Leu Leu Ala Pro Glu Met 
305                 310                 315                 320 


Glu Asp Asn Glu Met Ser Cys Ser Pro 
                325                 


<210>  72
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Ala Leu Asn Ile Ala Thr His Val Leu Lys Pro Gly Gly Cys Phe 
1               5                   10                  15      


Val Ala Lys Ile Phe Arg Gly Arg Asp Val Thr Leu Leu Tyr Ser Gln 
            20                  25                  30          


Leu Gln Val Phe Phe Ser Ser Val Leu Cys Ala Lys Pro Arg Ser Ser 
        35                  40                  45              


Arg Asn Ser Ser Ile Glu Ala Phe Ala Val Cys Gln Gly Tyr Asp Pro 
    50                  55                  60                  


Pro Glu Gly Phe Ile Pro Asp Leu Ser Lys Pro Leu Leu Asp His Ser 
65                  70                  75                  80  


Tyr Asp Pro Asp Phe Asn Gln Leu Asp Gly Pro Thr Arg Ile Ile Val 
                85                  90                  95      


Pro Phe Val Thr Cys Gly Asp Leu Ser Ser Tyr Asp Ser Asp Arg Ser 
            100                 105                 110         


Tyr Pro Leu Asp Leu Glu Gly Gly Ser Glu Tyr Lys Tyr Thr Pro Pro 
        115                 120                 125             


Thr Gln Pro Pro Ile Ser Pro Pro Tyr Gln Glu Ala Cys Thr Leu Lys 
    130                 135                 140                 


Arg Lys Gly Gln Leu Ala Lys Glu Ile Arg Pro Gln Asp Cys Pro Ile 
145                 150                 155                 160 


Ser Arg Val Asp Thr Phe Pro Gln Pro Leu Ala Ala Pro Gln Cys His 
                165                 170                 175     


Thr Leu Leu Ala Pro Glu Met Glu Asp Asn Glu Met Ser Cys Ser Pro 
            180                 185                 190         


<210>  73
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Lys Met Ala Ser Ser Leu Ala Phe Leu Leu Leu Asn Phe His Val 
1               5                   10                  15      


Ser Leu Leu Leu Val Gln Leu Leu Thr Pro Cys Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Ala Leu Gly Ser Asn Leu His Val Glu Val Lys Gly Tyr Glu Asp Gly 
145                 150                 155                 160 


Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln 
                165                 170                 175     


Ile Gln Trp Ser Asn Ala Lys Gly Glu Asn Ile Pro Ala Val Glu Ala 
            180                 185                 190         


Pro Val Val Ala Asp Gly Val Gly Leu Tyr Glu Val Ala Ala Ser Val 
        195                 200                 205             


Ile Met Arg Gly Gly Ser Gly Glu Gly Val Ser Cys Ile Ile Arg Asn 
    210                 215                 220                 


Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro 
225                 230                 235                 240 


Phe Phe Arg Ser Ala Gln Pro Trp Ile Ala Ala Leu Ala Gly Thr Leu 
                245                 250                 255     


Pro Ile Leu Leu Leu Leu Leu Ala Gly Ala Ser Tyr Phe Leu Trp Arg 
            260                 265                 270         


Gln Gln Lys Glu Ile Thr Ala Leu Ser Ser Glu Ile Glu Ser Glu Gln 
        275                 280                 285             


Glu Met Lys Glu Met Gly Tyr Ala Ala Thr Glu Arg Glu Ile Ser Leu 
    290                 295                 300                 


Arg Glu Ser Leu Gln Glu Glu Leu Lys Arg Lys Lys Ile Gln Tyr Leu 
305                 310                 315                 320 


Thr Arg Gly Glu Glu Ser Ser Ser Asp Thr Asn Lys Ser Ala 
                325                 330                 


<210>  74
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Gly Ile Pro Arg Ala Gln Phe Ser Val Leu Gly Pro Ser Gly Pro 
1               5                   10                  15      


Ile Leu Ala Met Val Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe 
            20                  25                  30          


Pro Thr Met Ser Ala Glu Thr Met Glu Leu Lys Trp Val Ser Ser Ser 
        35                  40                  45              


Leu Arg Gln Val Val Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp 
    50                  55                  60                  


Arg Gln Ser Ala Pro Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly 
65                  70                  75                  80  


Ile Thr Ala Gly Lys Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser 
                85                  90                  95      


Asp Ser Gly Lys Tyr Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu 
            100                 105                 110         


Lys Ala Leu Val Glu Leu Lys Val Ala Ala Leu Gly Ser Asn Leu His 
        115                 120                 125             


Val Glu Val Lys Gly Tyr Glu Asp Gly Gly Ile His Leu Glu Cys Arg 
    130                 135                 140                 


Ser Thr Gly Trp Tyr Pro Gln Pro Gln Ile Gln Trp Ser Asn Ala Lys 
145                 150                 155                 160 


Gly Glu Asn Ile Pro Ala Val Glu Ala Pro Val Val Ala Asp Gly Val 
                165                 170                 175     


Gly Leu Tyr Glu Val Ala Ala Ser Val Ile Met Arg Gly Gly Ser Gly 
            180                 185                 190         


Glu Gly Val Ser Cys Ile Ile Arg Asn Ser Leu Leu Gly Leu Glu Lys 
        195                 200                 205             


Thr Ala Ser Ile Ser Ile Ala Asp Pro Phe Phe Arg Ser Ala Gln Pro 
    210                 215                 220                 


Trp Ile Ala Ala Leu Ala Gly Thr Leu Pro Ile Leu Leu Leu Leu Leu 
225                 230                 235                 240 


Ala Gly Ala Ser Tyr Phe Leu Trp Arg Gln Gln Lys Glu Ile Thr Ala 
                245                 250                 255     


Leu Ser Ser Glu Ile Glu Ser Glu Gln Glu Met Lys Glu Met Gly Tyr 
            260                 265                 270         


Ala Ala Thr Glu Arg Glu Ile Ser Leu Arg Glu Ser Leu Gln Glu Glu 
        275                 280                 285             


Leu Lys Arg Lys Lys Ile Gln Tyr Leu Thr Arg Gly Glu Glu Ser Ser 
    290                 295                 300                 


Ser Asp Thr Asn Lys Ser Ala 
305                 310     


<210>  75
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Val Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe Pro Thr Met 
1               5                   10                  15      


Ser Ala Glu Thr Met Glu Leu Lys Trp Val Ser Ser Ser Leu Arg Gln 
            20                  25                  30          


Val Val Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp Arg Gln Ser 
        35                  40                  45              


Ala Pro Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala 
    50                  55                  60                  


Gly Lys Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly 
65                  70                  75                  80  


Lys Tyr Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu 
                85                  90                  95      


Val Glu Leu Lys Val Ala Ala Leu Gly Ser Asn Leu His Val Glu Val 
            100                 105                 110         


Lys Gly Tyr Glu Asp Gly Gly Ile His Leu Glu Cys Arg Ser Thr Gly 
        115                 120                 125             


Trp Tyr Pro Gln Pro Gln Ile Gln Trp Ser Asn Ala Lys Gly Glu Asn 
    130                 135                 140                 


Ile Pro Ala Val Glu Ala Pro Val Val Ala Asp Gly Val Gly Leu Tyr 
145                 150                 155                 160 


Glu Val Ala Ala Ser Val Ile Met Arg Gly Gly Ser Gly Glu Gly Val 
                165                 170                 175     


Ser Cys Ile Ile Arg Asn Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser 
            180                 185                 190         


Ile Ser Ile Ala 
        195     


<210>  76
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Val Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe Pro Thr Met 
1               5                   10                  15      


Ser Ala Glu Thr Met Glu Leu Lys Trp Val Ser Ser Ser Leu Arg Gln 
            20                  25                  30          


Val Val Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp Arg Gln Ser 
        35                  40                  45              


Ala Pro Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala 
    50                  55                  60                  


Gly Lys Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly 
65                  70                  75                  80  


Lys Tyr Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu 
                85                  90                  95      


Val Glu Leu Lys Val Ala Ala Leu Gly Ser Asn Leu His Val Glu Val 
            100                 105                 110         


Lys Gly Tyr 
        115 


<210>  77
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  77

Arg Gly Gly Ser Gly Glu Gly Val Ser Cys Ile Ile Arg Asn Ser Leu 
1               5                   10                  15      


Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro Phe Phe 
            20                  25                  30          


Arg Ser Ala Gln Pro Trp Ile Ala Ala Leu Ala Gly Thr Leu Pro Ile 
        35                  40                  45              


Leu Leu Leu Leu Leu Ala Gly Ala Ser Tyr Phe Leu Trp Arg Gln Gln 
    50                  55                  60                  


Lys Glu Ile Thr Ala Leu Ser Ser Glu Ile Glu Ser Glu Gln Glu Met 
65                  70                  75                  80  


Lys Glu Met Gly Tyr Ala Ala Thr Glu Arg Glu Ile Ser Leu Arg Glu 
                85                  90                  95      


Ser Leu Gln Glu Glu Leu Lys Arg Lys Lys Ile Gln Tyr Leu Thr Arg 
            100                 105                 110         


Glu Trp Leu 
        115 


<210>  78
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Lys Met Ala Ser Ser Leu Ala Phe Leu Leu Leu Asn Phe His Val 
1               5                   10                  15      


Ser Leu Leu Leu Val Gln Leu Leu Thr Pro Cys Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Asp Pro Phe Phe Arg Ser Ala Gln Pro Trp Ile Ala Ala Leu Ala Gly 
145                 150                 155                 160 


<210>  79
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Lys Met Ala Ser Ser Leu Ala Phe Leu Leu Leu Asn Phe His Val 
1               5                   10                  15      


Ser Leu Leu Leu Val Gln Leu Leu Thr Pro Cys Ser Gly Leu Cys Ser 
            20                  25                  30          


Pro Leu Gly Ser Leu Tyr Leu Ala Phe Pro Val 
        35                  40              


<210>  80
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Val Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe Pro Thr Met 
1               5                   10                  15      


Ser Ala Glu Thr Met Glu Leu Lys Trp Val Ser Ser Ser Leu Arg Gln 
            20                  25                  30          


Val Val Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp Arg Gln Ser 
        35                  40                  45              


Ala Pro Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala 
    50                  55                  60                  


Gly Lys Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly 
65                  70                  75                  80  


Lys Tyr Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu 
                85                  90                  95      


Val Glu Leu Lys Val Ala Ala Leu Gly Ser Asn Leu His Val Glu Val 
            100                 105                 110         


Lys Gly Tyr Glu Asp Gly Gly Ile His Leu Glu Cys Arg Ser Thr Gly 
        115                 120                 125             


Trp Tyr Pro Gln Pro Gln Ile Gln Trp Ser Asn Ala Lys Gly Glu Asn 
    130                 135                 140                 


Ile Pro Ala Val Glu Ala Pro Val Val Ala Asp Gly Val Gly Leu Tyr 
145                 150                 155                 160 


Glu Val Ala Ala Ser Val Ile Met Arg Gly Gly Ser Gly Glu Gly Val 
                165                 170                 175     


Ser Cys Ile Ile Arg Asn Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser 
            180                 185                 190         


Ile Ser Ile Ala Asp Pro Phe Phe Arg Ser Ala Gln Pro Trp Ile Ala 
        195                 200                 205             


Ala Leu Ala Gly Thr Leu Pro Ile Leu Leu Leu Leu Leu Ala Gly Ala 
    210                 215                 220                 


Ser Tyr Phe Leu Trp Arg Gln Gln Lys Glu Ile Thr Ala Leu Ser Ser 
225                 230                 235                 240 


Glu Ile Glu Ser Glu Gln Glu Met Lys Glu Met Gly Tyr Ala Ala Thr 
                245                 250                 255     


Glu Arg Glu Ile Ser Leu Arg Glu Ser Leu Gln Glu Glu Leu Lys Arg 
            260                 265                 270         


Lys Lys Ile Gln Tyr Leu Thr Arg Gly Glu Glu Ser Ser Ser Asp Thr 
        275                 280                 285             


Asn Lys Ser Ala 
    290         


<210>  81
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val 
1               5                   10                  15      


Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Ala Leu Gly Ser Asp Leu His Val Asp Val Lys Gly Tyr Lys Asp Gly 
145                 150                 155                 160 


Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln 
                165                 170                 175     


Ile Gln Trp Ser Asn Asn Lys Gly Glu Asn Ile Pro Thr Val Glu Ala 
            180                 185                 190         


Pro Val Val Ala Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val 
        195                 200                 205             


Ile Met Arg Gly Ser Ser Gly Glu Gly Val Ser Cys Thr Ile Arg Ser 
    210                 215                 220                 


Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro 
225                 230                 235                 240 


Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala Ala Leu Ala Gly Thr Leu 
                245                 250                 255     


Pro Val Leu Leu Leu Leu Leu Gly Gly Ala Gly Tyr Phe Leu Trp Gln 
            260                 265                 270         


Gln Gln Glu Glu Lys Lys Thr Gln Phe Arg Lys Lys Lys Arg Glu Gln 
        275                 280                 285             


Glu Leu Arg Glu Met Ala Trp Ser Thr Met Lys Gln Glu Gln Ser Thr 
    290                 295                 300                 


Arg Val Lys Leu Leu Glu Glu Leu Arg Trp Arg Ser Ile Gln Tyr Ala 
305                 310                 315                 320 


Ser Arg Gly Glu Arg His Ser Ala Tyr Asn Glu Trp Lys Lys Ala Leu 
                325                 330                 335     


Phe Lys Pro Ala Asp Val Ile Leu Asp Pro Lys Thr Ala Asn Pro Ile 
            340                 345                 350         


Leu Leu Val Ser Glu Asp Gln Arg Ser Val Gln Arg Ala Lys Glu Pro 
        355                 360                 365             


Gln Asp Leu Pro Asp Asn Pro Glu Arg Phe Asn Trp His Tyr Cys Val 
    370                 375                 380                 


Leu Gly Cys Glu Ser Phe Ile Ser Gly Arg His Tyr Trp Glu Val Glu 
385                 390                 395                 400 


Val Gly Asp Arg Lys Glu Trp His Ile Gly Val Cys Ser Lys Asn Val 
                405                 410                 415     


Gln Arg Lys Gly Trp Val Lys Met Thr Pro Glu Asn Gly Phe Trp Thr 
            420                 425                 430         


Met Gly Leu Thr Asp Gly Asn Lys Tyr Arg Thr Leu Thr Glu Pro Arg 
        435                 440                 445             


Thr Asn Leu Lys Leu Pro Lys Pro Pro Lys Lys Val Gly Val Phe Leu 
    450                 455                 460                 


Asp Tyr Glu Thr Gly Asp Ile Ser Phe Tyr Asn Ala Val Asp Gly Ser 
465                 470                 475                 480 


His Ile His Thr Phe Leu Asp Val Ser Phe Ser Glu Ala Leu Tyr Pro 
                485                 490                 495     


Val Phe Arg Ile Leu Thr Leu Glu Pro Thr Ala Leu Thr Ile Cys Pro 
            500                 505                 510         


Ala 
    


<210>  82
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val 
1               5                   10                  15      


Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met 
        35                  40              


<210>  83
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val 
1               5                   10                  15      


Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Ala Leu Gly Ser Asp Leu His Val Asp Val Lys Gly Tyr Lys Asp Gly 
145                 150                 155                 160 


Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln 
                165                 170                 175     


Ile Gln Trp Ser Asn Asn Lys Gly Glu Asn Ile Pro Thr Val Glu Ala 
            180                 185                 190         


Pro Val Val Ala Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val 
        195                 200                 205             


Ile Met Arg Gly Ser Ser Gly Glu Gly Val Ser Cys Thr Ile Arg Ser 
    210                 215                 220                 


Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro 
225                 230                 235                 240 


Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala Ala Leu Ala Gly Thr Leu 
                245                 250                 255     


Pro Val Leu Leu Leu Leu Leu Gly Gly Ala Gly Tyr Phe Leu Trp Gln 
            260                 265                 270         


Gln Gln Glu Glu Lys Lys Thr Gln Phe Arg Lys Lys Lys Arg Glu Gln 
        275                 280                 285             


Glu Leu Arg Glu Met Ala Trp Ser Thr Met Lys Gln Glu Gln Ser Thr 
    290                 295                 300                 


Arg Val Lys Leu Leu Glu Glu Leu Arg Trp Arg Ser Ile Gln Tyr Ala 
305                 310                 315                 320 


Ser Arg Gly Glu Arg His Ser Ala Tyr Asn Glu Trp Lys Lys Ala Leu 
                325                 330                 335     


Phe Lys Pro Gly Glu Glu Met Leu Gln Met Arg Leu His Phe Val Lys 
            340                 345                 350         


<210>  84
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val 
1               5                   10                  15      


Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser 
        115                 


<210>  85
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val 
1               5                   10                  15      


Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val Ile Met Arg Gly 
145                 150                 155                 160 


Ser Ser Gly Glu Gly Val Ser Cys Thr Ile Arg Ser Ser Leu Leu Gly 
                165                 170                 175     


Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro Phe Phe Arg Ser 
            180                 185                 190         


Ala Gln Arg Trp Ile Ala Ala Leu Ala Gly Thr Leu Pro Val Leu Leu 
        195                 200                 205             


Leu Leu Leu Gly Gly Ala Gly Tyr Phe Leu Trp Gln Gln Gln Glu Glu 
    210                 215                 220                 


Lys Lys Thr Gln Phe Arg Lys Lys Lys Arg Glu Gln Glu Leu Arg Glu 
225                 230                 235                 240 


Met Ala Trp Ser Thr Met Lys Gln Glu Gln Ser Thr Arg Val Lys Leu 
                245                 250                 255     


Leu Glu Glu Leu Arg Trp Arg Ser Ile Gln Tyr Ala Ser Arg Gly Glu 
            260                 265                 270         


Arg His Ser Ala Tyr Asn Glu Trp Lys Lys Ala Leu Phe Lys Pro Ala 
        275                 280                 285             


Asp Val Ile Leu Asp Pro Lys Thr Ala Asn Pro Ile Leu Leu Val Ser 
    290                 295                 300                 


Glu Asp Gln Arg Ser Val Gln Arg Ala Lys Glu Pro Gln Asp Leu Pro 
305                 310                 315                 320 


Asp Asn Pro Glu Arg Phe Asn Trp His Tyr Cys Val Leu Gly Cys Glu 
                325                 330                 335     


Ser Phe Ile Ser Gly Arg His Tyr Trp Glu Val Glu Val Gly Asp Arg 
            340                 345                 350         


Lys Glu Trp His Ile Gly Val Cys Ser Lys Asn Val Gln Arg Lys Gly 
        355                 360                 365             


Trp Val Lys Met Thr Pro Glu Asn Gly Phe Trp Thr Met Gly Leu Thr 
    370                 375                 380                 


Asp Gly Asn Lys Tyr Arg Thr Leu Thr Glu Pro Arg Thr Asn Leu Lys 
385                 390                 395                 400 


Leu Pro Lys Pro Pro Lys Lys Val Gly Val Phe Leu Asp Tyr Glu Thr 
                405                 410                 415     


Gly Asp Ile Ser Phe Tyr Asn Ala Val Asp Gly Ser His Ile His Thr 
            420                 425                 430         


Phe Leu Asp Val Ser Phe Ser Glu Ala Leu Tyr Pro Val Phe Arg Ile 
        435                 440                 445             


Leu Thr Leu Glu Pro Thr Ala Leu Thr Ile Cys Pro Ala 
    450                 455                 460     


<210>  86
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val 
1               5                   10                  15      


Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Ala Leu Gly Ser Asp Leu His Val Asp Val Lys Gly Tyr Lys Asp Gly 
145                 150                 155                 160 


Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln 
                165                 170                 175     


Ile Gln Trp Ser Asn Asn Lys Gly Glu Asn Ile Pro Thr Val Glu Ala 
            180                 185                 190         


Pro Val Val Ala Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val 
        195                 200                 205             


Ile Met Arg Gly Ser Ser Gly Glu Gly Val Ser Cys Thr Ile Arg Ser 
    210                 215                 220                 


Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro 
225                 230                 235                 240 


Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala Ala Leu Ala Gly Thr Leu 
                245                 250                 255     


Pro Val Leu Leu Leu Leu Leu Gly Gly Ala Gly Tyr Phe Leu Trp Gln 
            260                 265                 270         


Gln Gln Glu Glu Lys Lys Thr Gln Phe Arg Lys Lys Lys Arg Glu Gln 
        275                 280                 285             


Glu Leu Arg Glu Met Ala Trp Ser Thr Met Lys Gln Glu Gln Ser Thr 
    290                 295                 300                 


Arg Val Lys Leu Leu Glu Glu Leu Arg Trp Arg Ser Ile Gln Tyr Ala 
305                 310                 315                 320 


Ser Arg Gly Glu Arg His Ser Ala Tyr Asn Glu Trp Lys Lys Ala Leu 
                325                 330                 335     


Phe Lys Pro Gly Pro Pro Ile Gly Gln Thr Gln Gln Gln Thr Arg Gly 
            340                 345                 350         


Gln Gly Ser Pro Val Ala Leu Ser Gln Glu Ser Ala Gln Arg Thr Asp 
        355                 360                 365             


Ser Trp Gly Pro Glu Glu Gly Gly Glu Ser 
    370                 375             


<210>  87
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val 
1               5                   10                  15      


Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro 
                85                  90          


<210>  88
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Glu Ser Ala Ala Ala Leu His Phe Ser Arg Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Ala Gln Phe Ile Val 
            20                  25                  30          


Val Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr 
        35                  40                  45              


Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val 
    50                  55                  60                  


Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly 
65                  70                  75                  80  


Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr 
                85                  90                  95      


Thr Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile 
            100                 105                 110         


His Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln 
        115                 120                 125             


Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Val Ala Gly 
    130                 135                 140                 


Leu Gly Ser Lys Pro Leu Ile Ser Met Arg Gly His Glu Asp Gly Gly 
145                 150                 155                 160 


Ile Arg Leu Glu Cys Ile Ser Arg Gly Trp Tyr Pro Lys Pro Leu Thr 
                165                 170                 175     


Val Trp Arg Asp Pro Tyr Gly Gly Val Ala Pro Ala Leu Lys Glu Val 
            180                 185                 190         


Ser Met Pro Asp Ala Asp Gly Leu Phe Met Val Thr Thr Ala Val Ile 
        195                 200                 205             


Ile Arg Asp Lys Ser Val Arg Asn Met Ser Cys Ser Ile Asn Asn Thr 
    210                 215                 220                 


Leu Leu Gly Gln Lys Lys Glu Ser Val Ile Phe Ile Pro Glu Ser Phe 
225                 230                 235                 240 


Met Pro Ser Val Ser Pro Cys Ala Val Ala Leu Pro Ile Ile Val Val 
                245                 250                 255     


Ile Leu Met Ile Pro Ile Ala Val Cys Ile Tyr Trp Ile Asn Lys Leu 
            260                 265                 270         


Gln Lys Glu Lys Lys Ile Leu Ser Gly Glu Lys Glu Phe Glu Arg Glu 
        275                 280                 285             


Thr Arg Glu Ile Ala Leu Lys Glu Leu Glu Lys Glu Arg Val Gln Lys 
    290                 295                 300                 


Glu Glu Glu Leu Gln Val Lys Glu Lys Leu Gln Glu Glu Leu Arg Trp 
305                 310                 315                 320 


Arg Arg Thr Phe Leu His Ala Val Asp Val Val Leu Asp Pro Asp Thr 
                325                 330                 335     


Ala His Pro Asp Leu Phe Leu Ser Glu Asp Arg Arg Ser Val Arg Arg 
            340                 345                 350         


Cys Pro Phe Arg His Leu Gly Glu Ser Val Pro Asp Asn Pro Glu Arg 
        355                 360                 365             


Phe Asp Ser Gln Pro Cys Val Leu Gly Arg Glu Ser Phe Ala Ser Gly 
    370                 375                 380                 


Lys His Tyr Trp Glu Val Glu Val Glu Asn Val Ile Glu Trp Thr Val 
385                 390                 395                 400 


Gly Val Cys Arg Asp Ser Val Glu Arg Lys Gly Glu Val Leu Leu Ile 
                405                 410                 415     


Pro Gln Asn Gly Phe Trp Thr Leu Glu Met His Lys Gly Gln Tyr Arg 
            420                 425                 430         


Ala Val Ser Ser Pro Asp Arg Ile Leu Pro Leu Lys Glu Ser Leu Cys 
        435                 440                 445             


Arg Val Gly Val Phe Leu Asp Tyr Glu Ala Gly Asp Val Ser Phe Tyr 
    450                 455                 460                 


Asn Met Arg Asp Arg Ser His Ile Tyr Thr Cys Pro Arg Ser Ala Phe 
465                 470                 475                 480 


Ser Val Pro Val Arg Pro Phe Phe Arg Leu Gly Cys Glu Asp Ser Pro 
                485                 490                 495     


Ile Phe Ile Cys Pro Ala Leu Thr Gly Ala Asn Gly Val Thr Val Pro 
            500                 505                 510         


Glu Glu Gly Leu Thr Leu His Arg Val Gly Thr His Gln Ser Leu 
        515                 520                 525         


<210>  89
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Glu Ser Ala Ala Ala Leu His Phe Ser Arg Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Ala Gln Phe Ile Val 
            20                  25                  30          


Val Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr 
        35                  40                  45              


Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val 
    50                  55                  60                  


Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly 
65                  70                  75                  80  


Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr 
                85                  90                  95      


Thr Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile 
            100                 105                 110         


His Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln 
        115                 120                 125             


Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Val Ala Glu 
    130                 135                 140                 


Leu Leu Glu Ala Glu Val Tyr 
145                 150     


<210>  90
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Glu Ser Ala Ala Ala Leu His Phe Ser Arg Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Ala Gln Phe Ile Val 
            20                  25                  30          


Val Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr 
        35                  40                  45              


Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val 
    50                  55                  60                  


Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly 
65                  70                  75                  80  


Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr 
                85                  90                  95      


Thr Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile 
            100                 105                 110         


His Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln 
        115                 120                 125             


Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Val Ala Gly 
    130                 135                 140                 


Leu Gly Ser Lys Pro Leu Ile Ser Met Arg Gly His Glu Asp Gly Gly 
145                 150                 155                 160 


Ile Arg Leu Glu Cys Ile Ser Arg Gly Trp Tyr Pro Lys Pro Leu Thr 
                165                 170                 175     


Val Trp Arg Asp Pro Tyr Gly Gly Val Ala Pro Ala Leu Lys Glu Val 
            180                 185                 190         


Ser Met Pro Asp Ala Asp Gly Leu Phe Met Val Thr Thr Ala Val Ile 
        195                 200                 205             


Ile Arg Asp Lys Ser Val Arg Asn Met Ser Cys Ser Ile Asn Asn Thr 
    210                 215                 220                 


Leu Leu Gly Gln Lys Lys Glu Ser Val Ile Phe Ile Pro Glu Ser Phe 
225                 230                 235                 240 


Met Pro Ser Val Ser Pro Cys Ala Val Ala Leu Pro Ile Ile Val Val 
                245                 250                 255     


Ile Leu Met Ile Pro Ile Ala Val Cys Ile Tyr Trp Ile Asn Lys Leu 
            260                 265                 270         


Gln Lys Glu Lys Lys Ile Leu Ser Gly Glu Lys Glu Phe Glu Arg Glu 
        275                 280                 285             


Thr Arg Glu Ile Ala Leu Lys Glu Leu Glu Lys Glu Arg Val Gln Lys 
    290                 295                 300                 


Glu Glu Glu Leu Gln Val Lys Glu Lys Leu Gln Glu Glu Leu Arg Trp 
305                 310                 315                 320 


Arg Arg Thr Phe Leu His Ala Gly Pro Val 
                325                 330 


<210>  91
<211>  78
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  91

Xaa Ile Ile Val Val Ile Leu Met Ile Pro Ile Ala Val Cys Ile Tyr 
1               5                   10                  15      


Trp Ile Asn Lys Leu Gln Lys Glu Lys Lys Ile Leu Ser Gly Glu Lys 
            20                  25                  30          


Glu Phe Glu Arg Glu Thr Arg Glu Ile Ala Leu Lys Glu Leu Glu Lys 
        35                  40                  45              


Glu Arg Val Gln Lys Glu Glu Glu Leu Gln Val Lys Glu Lys Leu Gln 
    50                  55                  60                  


Glu Glu Leu Arg Trp Arg Arg Thr Phe Leu His Ala Gly Trp 
65                  70                  75              


<210>  92
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Glu Val Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val 
1               5                   10                  15      


Tyr Lys Gly Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg 
            20                  25                  30          


Gly Arg Thr Thr Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala 
        35                  40                  45              


Leu Val Ile His Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys 
    50                  55                  60                  


Tyr Phe Gln Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val 
65                  70                  75                  80  


Val Ala Gly Leu Gly Ser 
                85      


<210>  93
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Glu Ser Ala Ala Ala Leu His Phe Ser Arg Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Ala Gln Phe Ile Val 
            20                  25                  30          


Val Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr 
        35                  40                  45              


Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val 
    50                  55                  60                  


Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly 
65                  70                  75                  80  


Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr 
                85                  90                  95      


Thr Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile 
            100                 105                 110         


His Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln 
        115                 120                 125             


Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Val Ala Gly 
    130                 135                 140                 


Leu Gly Ser Lys Pro Leu Ile Ser Met Arg Gly His Glu Asp Gly Gly 
145                 150                 155                 160 


Ile Arg Leu Glu Cys Ile Ser Arg Gly Trp Tyr Pro Lys Pro Leu Thr 
                165                 170                 175     


Val Trp Arg Asp Pro Tyr Gly Gly Val Ala Pro Ala Leu Lys Glu Val 
            180                 185                 190         


Ser Met Pro Asp Ala Asp Gly Leu Phe Met Val Thr Thr Ala Val Ile 
        195                 200                 205             


Ile Arg Asp Lys Ser Val Arg Asn Met Ser Cys Ser Ile Asn Asn Thr 
    210                 215                 220                 


Leu Leu Gly Gln Lys Lys Glu Ser Val Ile Phe Ile Pro Glu Ser Phe 
225                 230                 235                 240 


Met Pro Ser Val Ser Pro Cys Ala Val Ala Leu Pro Ile Ile Val Val 
                245                 250                 255     


Ile Leu Met Ile Pro Ile Ala Val Cys Ile Tyr Trp Ile Asn Lys Leu 
            260                 265                 270         


Gln Lys Glu Lys Lys Ile Leu Ser Gly Glu Lys Glu Phe Glu Arg Glu 
        275                 280                 285             


Thr Arg Glu Ile Ala Leu Lys Glu Leu Glu Lys Glu Arg Val Gln Lys 
    290                 295                 300                 


Glu Glu Glu Leu Gln Val Lys Glu Lys Leu Gln Glu Glu Leu Arg Trp 
305                 310                 315                 320 


Arg Arg Thr Phe Leu His Ala Glu Leu Gln Phe Phe Ser Asn 
                325                 330                 


<210>  94
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Glu Val Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val 
1               5                   10                  15      


Tyr Lys Gly Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg 
            20                  25                  30          


Gly Arg Thr Thr Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala 
        35                  40                  45              


Leu Val Ile His Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys 
    50                  55                  60                  


Tyr Phe Gln Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val 
65                  70                  75                  80  


Val Ala Gly Leu Gly Ser Lys Pro Leu Ile Ser Met Arg Gly His Glu 
                85                  90                  95      


Asp Gly Gly Ile Arg Leu Glu Cys Ile Ser Arg Gly Trp Tyr Pro Lys 
            100                 105                 110         


Pro Leu Thr Val Trp Arg Asp Pro Tyr Gly Gly Val Ala Pro Ala Leu 
        115                 120                 125             


Lys Glu Val Ser Met Pro Asp Ala Asp Gly Leu Phe Met Val Thr Thr 
    130                 135                 140                 


Ala Val Ile Ile Arg Asp Lys Ser Val Arg Asn Met Ser Cys Ser Ile 
145                 150                 155                 160 


Asn Asn Thr Leu Leu Gly Gln Lys Lys Glu Ser Val Ile Phe Ile Pro 
                165                 170                 175     


Glu Ser Phe Met Pro Ser Val Ser Pro Cys Ala Val Ala Leu Pro Ile 
            180                 185                 190         


Ile Val Val Ile Leu Met Ile Pro Ile Ala Val Cys Ile Tyr Trp Ile 
        195                 200                 205             


Asn Lys Leu Gln Lys Glu Lys Lys Ile Leu Ser Gly Glu Lys Glu Phe 
    210                 215                 220                 


Glu Arg Glu Thr Arg Glu Ile Ala Leu Lys Glu Leu Glu Lys Glu Arg 
225                 230                 235                 240 


Val Gln Lys Glu Glu Glu Leu Gln Val Lys Glu Lys Leu Gln Glu Glu 
                245                 250                 255     


Leu Arg Trp Arg Arg Thr Phe Leu His Ala Val Asp Val Val Leu Asp 
            260                 265                 270         


Pro Asp Thr Ala His Pro Asp Leu Phe Leu Ser Glu Asp Arg Arg Ser 
        275                 280                 285             


Val Arg Arg Cys Pro Phe Arg His Leu Gly Glu Ser Val Pro Asp Asn 
    290                 295                 300                 


Pro Glu Arg Phe Asp Ser Gln Pro Cys Val Leu Gly Arg Glu Ser Phe 
305                 310                 315                 320 


Ala Ser Gly Lys His Tyr Trp Glu Val Glu Val Glu Asn Val Ile Glu 
                325                 330                 335     


Trp Thr Val Gly Val Cys Arg Asp Ser Val Glu Arg Lys Gly Glu Val 
            340                 345                 350         


Leu Leu Ile Pro Gln Asn Gly Phe Trp Thr Leu Glu Met His Lys Gly 
        355                 360                 365             


Gln Tyr Arg Ala Val Ser Ser Pro Asp Arg Ile Leu Pro Leu Lys Glu 
    370                 375                 380                 


Ser Leu Cys Arg Val Gly Val Phe Leu Asp Tyr Glu Ala Gly Asp Val 
385                 390                 395                 400 


Ser Phe Tyr Asn Met Arg Asp Arg Ser His Ile Tyr Thr Cys Pro Arg 
                405                 410                 415     


Ser Ala Phe Ser Val Pro Val Arg Pro Phe Phe Arg Leu Gly Cys Glu 
            420                 425                 430         


Asp Ser Pro Ile Phe Ile Cys Pro Ala Leu Thr Gly Ala Asn Gly Val 
        435                 440                 445             


Thr Val Pro Glu Glu Gly Leu Thr Leu His Arg Val Gly Thr His Gln 
    450                 455                 460                 


Ser Leu 
465     


<210>  95
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Lys Glu Val Val Tyr Trp Ser Pro Lys Lys Val Ala Asp Trp Leu 
1               5                   10                  15      


Leu Glu Asn Ala Met Pro Glu Tyr Cys Glu Pro Leu Glu His Phe Thr 
            20                  25                  30          


Gly Gln Asp Leu Ile Asn Leu Thr Gln Glu Asp Phe Lys Lys Pro Pro 
        35                  40                  45              


Leu Cys Arg Val Ser Ser Asp Asn Gly Gln Arg Leu Leu Asp Met Ile 
    50                  55                  60                  


Glu Thr Leu Lys Met Glu His His Leu Glu Ala His Lys Asn Gly His 
65                  70                  75                  80  


Ala Asn Gly His Leu Asn Ile Gly Val Asp Ile Pro Thr Pro Asp Gly 
                85                  90                  95      


Ser Phe Ser Ile Lys Ile Lys Pro Asn Gly Met Pro Asn Gly Tyr Arg 
            100                 105                 110         


Lys Glu Met Ile Lys Ile Pro Met Pro Glu Leu Glu Arg Ser Gln Tyr 
        115                 120                 125             


Pro Met Glu Trp Gly Lys Thr Phe Leu Ala Phe Leu Tyr Ala Leu Ser 
    130                 135                 140                 


Cys Phe Val Leu Thr Thr Val Met Ile Ser Val Val His Glu Arg Val 
145                 150                 155                 160 


Pro Pro Lys Glu Val Gln Pro Pro Leu Pro Asp Thr Phe Phe Asp His 
                165                 170                 175     


Phe Asn Arg Val Gln Trp Ala Phe Ser Ile Cys Glu Ile Asn Gly Met 
            180                 185                 190         


Ile Leu Val Gly Leu Trp Leu Ile Gln Trp Leu Leu Leu Lys Tyr Lys 
        195                 200                 205             


Asp Val Gly Asn Glu Ser Arg Val Val Met Ile Phe Leu Ser Ile Val 
    210                 215                 220                 


His Pro Val Leu Leu Leu Gly Ser Ile Ala Gly Phe Leu Ser Leu Ser 
225                 230                 235                 240 


Leu 
    


<210>  96
<211>  413
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Lys Glu Val Val Tyr Trp Ser Pro Lys Lys Val Ala Asp Trp Leu 
1               5                   10                  15      


Leu Glu Asn Ala Met Pro Glu Tyr Cys Glu Pro Leu Glu His Phe Thr 
            20                  25                  30          


Gly Gln Asp Leu Ile Asn Leu Thr Gln Glu Asp Phe Lys Lys Pro Pro 
        35                  40                  45              


Leu Cys Arg Val Ser Ser Asp Asn Gly Gln Arg Leu Leu Asp Met Ile 
    50                  55                  60                  


Glu Thr Leu Lys Met Glu His His Leu Glu Ala His Lys Asn Gly His 
65                  70                  75                  80  


Ala Asn Gly His Leu Asn Ile Gly Val Asp Ile Pro Thr Pro Asp Gly 
                85                  90                  95      


Ser Phe Ser Ile Lys Ile Lys Pro Asn Gly Met Pro Asn Gly Tyr Arg 
            100                 105                 110         


Lys Glu Met Ile Lys Ile Pro Met Pro Glu Leu Glu Arg Ser Gln Tyr 
        115                 120                 125             


Pro Met Glu Trp Gly Lys Thr Phe Leu Ala Phe Leu Tyr Ala Leu Ser 
    130                 135                 140                 


Cys Phe Val Leu Thr Thr Val Met Ile Ser Val Val His Glu Arg Val 
145                 150                 155                 160 


Pro Pro Lys Glu Val Gln Pro Pro Leu Pro Asp Thr Phe Phe Asp His 
                165                 170                 175     


Phe Asn Arg Val Gln Trp Ala Phe Ser Ile Cys Glu Ile Asn Gly Met 
            180                 185                 190         


Ile Leu Val Gly Leu Trp Leu Ile Gln Trp Leu Leu Leu Lys Tyr Lys 
        195                 200                 205             


Ser Ile Ile Ser Arg Arg Phe Phe Cys Ile Val Gly Thr Leu Tyr Leu 
    210                 215                 220                 


Tyr Arg Cys Ile Thr Met Tyr Val Thr Thr Leu Pro Val Pro Gly Met 
225                 230                 235                 240 


His Phe Asn Cys Ser Pro Lys Leu Phe Gly Asp Trp Glu Ala Gln Leu 
                245                 250                 255     


Arg Arg Ile Met Lys Leu Ile Ala Gly Gly Gly Leu Ser Ile Thr Gly 
            260                 265                 270         


Ser His Asn Met Cys Gly Asp Tyr Leu Tyr Ser Gly His Thr Val Met 
        275                 280                 285             


Leu Thr Leu Thr Tyr Leu Phe Ile Lys Glu Tyr Ser Pro Arg Arg Leu 
    290                 295                 300                 


Trp Trp Tyr His Trp Ile Cys Trp Leu Leu Ser Val Val Gly Ile Phe 
305                 310                 315                 320 


Cys Ile Leu Leu Ala His Asp His Tyr Thr Val Asp Val Val Val Ala 
                325                 330                 335     


Tyr Tyr Ile Thr Thr Arg Leu Phe Trp Trp Tyr His Thr Met Ala Asn 
            340                 345                 350         


Gln Gln Val Leu Lys Glu Ala Ser Gln Met Asn Leu Leu Ala Arg Val 
        355                 360                 365             


Trp Trp Tyr Arg Pro Phe Gln Tyr Phe Glu Lys Asn Val Gln Gly Ile 
    370                 375                 380                 


Val Pro Arg Ser Tyr His Trp Pro Phe Pro Trp Pro Val Val His Leu 
385                 390                 395                 400 


Ser Arg Gln Val Lys Tyr Ser Arg Leu Val Asn Asp Thr 
                405                 410             


<210>  97
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Lys Glu Val Val Tyr Trp Ser Pro Lys Lys Val Ala Asp Trp Leu 
1               5                   10                  15      


Leu Glu Asn Ala Met Pro Glu Tyr Cys Glu Pro Leu Glu His Phe Thr 
            20                  25                  30          


Gly Gln Asp Leu Ile Asn Leu Thr Gln Glu Asp Phe Lys Lys Pro Pro 
        35                  40                  45              


Leu Cys Arg Val Ser Ser Asp Asn Gly Gln Arg Leu Leu Asp Met Ile 
    50                  55                  60                  


Glu Thr Leu Lys Met Glu His His Leu Glu Ala His Lys Asn Gly His 
65                  70                  75                  80  


Ala Asn Gly His Leu Asn Ile Gly Val Asp Ile Pro Thr Pro Asp Gly 
                85                  90                  95      


Ser Phe Ser Ile Lys Ile Lys Pro Asn Gly Met Pro Asn Gly Tyr Arg 
            100                 105                 110         


Lys Glu Met Ile Lys Ile Pro Met Pro Glu Leu Glu Arg Ser Gln Tyr 
        115                 120                 125             


Pro Met Glu Trp Gly Lys Thr Phe Leu Ala Phe Leu Tyr Ala Leu Ser 
    130                 135                 140                 


Cys Phe Val Leu Thr Thr Val Met Ile Ser Val Val His Glu Arg Val 
145                 150                 155                 160 


Pro Pro Lys Glu Val Gln Pro Pro Leu Pro Asp Thr Phe Phe Asp His 
                165                 170                 175     


Phe Asn Arg Val Gln Trp Ala Phe Ser Ile Cys Glu Ile Asn Gly Met 
            180                 185                 190         


Ile Leu Val Gly Leu Trp Leu Ile Gln Trp Leu Leu Leu Lys Tyr Asn 
        195                 200                 205             


Phe Ser Glu Thr Gly Lys Pro Asn Cys Glu Glu 
    210                 215                 


<210>  98
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  98

Leu Trp Leu Ile Gln Trp Leu Leu Leu Lys Tyr Lys 
1               5                   10          


<210>  99
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Tyr Val Thr Thr Leu Pro Val Pro Gly Met His Phe Asn Cys Ser 
1               5                   10                  15      


Pro Lys Leu Phe Gly Asp Trp Glu Ala Gln Leu Arg Arg Ile Met Lys 
            20                  25                  30          


Leu Ile Ala Gly 
        35      


<210>  100
<211>  628
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Asp Ser Gly Ser Ser Ser Ser Asp Ser Ala Pro Asp Cys Trp Asp 
1               5                   10                  15      


Gln Val Asp Met Glu Ser Pro Gly Ser Ala Pro Ser Gly Asp Gly Val 
            20                  25                  30          


Ser Ser Ala Val Ala Glu Ala Gln Arg Glu Pro Leu Ser Ser Ala Phe 
        35                  40                  45              


Ser Arg Lys Leu Asn Val Asn Ala Lys Pro Phe Val Pro Asn Val His 
    50                  55                  60                  


Ala Ala Glu Phe Val Pro Ser Phe Leu Arg Gly Pro Thr Gln Pro Pro 
65                  70                  75                  80  


Thr Leu Pro Ala Gly Ser Gly Ser Asn Asp Glu Thr Cys Thr Gly Ala 
                85                  90                  95      


Gly Tyr Pro Gln Gly Lys Arg Met Gly Arg Gly Ala Pro Val Glu Pro 
            100                 105                 110         


Ser Arg Glu Glu Pro Leu Val Ser Leu Glu Gly Ser Asn Ser Ala Val 
        115                 120                 125             


Thr Met Glu Leu Ser Glu Pro Val Val Glu Asn Gly Glu Val Glu Met 
    130                 135                 140                 


Ala Leu Glu Glu Ser Trp Glu His Ser Lys Glu Val Ser Glu Ala Glu 
145                 150                 155                 160 


Pro Gly Gly Gly Ser Ser Gly Asp Ser Gly Pro Pro Glu Glu Ser Gly 
                165                 170                 175     


Gln Glu Met Met Glu Glu Lys Glu Glu Ile Arg Lys Ser Lys Ser Val 
            180                 185                 190         


Ile Val Pro Ser Gly Ala Pro Lys Lys Glu His Val Asn Val Val Phe 
        195                 200                 205             


Ile Gly His Val Asp Ala Gly Lys Ser Thr Ile Gly Gly Gln Ile Met 
    210                 215                 220                 


Phe Leu Thr Gly Met Val Asp Lys Arg Thr Leu Glu Lys Tyr Glu Arg 
225                 230                 235                 240 


Glu Ala Lys Glu Lys Asn Arg Glu Thr Trp Tyr Leu Ser Trp Ala Leu 
                245                 250                 255     


Asp Thr Asn Gln Glu Glu Arg Asp Lys Gly Lys Thr Val Glu Val Gly 
            260                 265                 270         


Arg Ala Tyr Phe Glu Thr Glu Arg Lys His Phe Thr Ile Leu Asp Ala 
        275                 280                 285             


Pro Gly His Lys Ser Phe Val Pro Asn Met Ile Gly Gly Ala Ser Gln 
    290                 295                 300                 


Ala Asp Leu Ala Val Leu Val Ile Ser Ala Arg Lys Gly Glu Phe Glu 
305                 310                 315                 320 


Thr Gly Phe Glu Lys Gly Gly Gln Thr Arg Glu His Ala Met Leu Ala 
                325                 330                 335     


Lys Thr Ala Gly Val Lys His Leu Ile Val Leu Ile Asn Lys Met Asp 
            340                 345                 350         


Asp Pro Thr Val Asn Trp Ser Ile Glu Arg Tyr Glu Glu Cys Lys Glu 
        355                 360                 365             


Lys Leu Val Pro Phe Leu Lys Lys Val Gly Phe Ser Pro Lys Lys Asp 
    370                 375                 380                 


Ile His Phe Met Pro Cys Ser Gly Leu Thr Gly Ala Asn Ile Lys Glu 
385                 390                 395                 400 


Gln Ser Asp Phe Cys Pro Trp Tyr Thr Gly Leu Pro Phe Ile Pro Tyr 
                405                 410                 415     


Leu Asp Asn Leu Pro Asn Phe Asn Arg Ser Ile Asp Gly Pro Ile Arg 
            420                 425                 430         


Leu Pro Ile Val Asp Lys Tyr Lys Asp Met Gly Thr Val Val Leu Gly 
        435                 440                 445             


Lys Leu Glu Ser Gly Ser Ile Phe Lys Gly Gln Gln Leu Val Met Met 
    450                 455                 460                 


Pro Asn Lys His Asn Val Glu Val Leu Gly Ile Leu Ser Asp Asp Thr 
465                 470                 475                 480 


Glu Thr Asp Phe Val Ala Pro Gly Glu Asn Leu Lys Ile Arg Leu Lys 
                485                 490                 495     


Gly Ile Glu Glu Glu Glu Ile Leu Pro Gly Phe Ile Leu Cys Asp Pro 
            500                 505                 510         


Ser Asn Leu Cys His Ser Gly Arg Thr Phe Asp Val Gln Ile Val Ile 
        515                 520                 525             


Ile Glu His Lys Ser Ile Ile Cys Pro Gly Tyr Asn Ala Val Leu His 
    530                 535                 540                 


Ile His Thr Cys Ile Glu Glu Val Glu Ile Thr Ala Leu Ile Ser Leu 
545                 550                 555                 560 


Val Asp Lys Lys Ser Gly Glu Lys Ser Lys Thr Arg Pro Arg Phe Val 
                565                 570                 575     


Lys Gln Asp Gln Val Cys Ile Ala Arg Leu Arg Thr Ala Gly Thr Ile 
            580                 585                 590         


Cys Leu Glu Thr Phe Lys Asp Phe Pro Gln Met Gly Arg Phe Thr Leu 
        595                 600                 605             


Arg Asp Glu Gly Lys Thr Ile Ala Ile Gly Lys Val Leu Lys Leu Val 
    610                 615                 620                 


Pro Glu Lys Asp 
625             


<210>  101
<211>  2442
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Ala Glu Asn Leu Leu Asp Gly Pro Pro Asn Pro Lys Arg Ala Lys 
1               5                   10                  15      


Leu Ser Ser Pro Gly Phe Ser Ala Asn Asp Ser Thr Asp Phe Gly Ser 
            20                  25                  30          


Leu Phe Asp Leu Glu Asn Asp Leu Pro Asp Glu Leu Ile Pro Asn Gly 
        35                  40                  45              


Gly Glu Leu Gly Leu Leu Asn Ser Gly Asn Leu Val Pro Asp Ala Ala 
    50                  55                  60                  


Ser Lys His Lys Gln Leu Ser Glu Leu Leu Arg Gly Gly Ser Gly Ser 
65                  70                  75                  80  


Ser Ile Asn Pro Gly Ile Gly Asn Val Ser Ala Ser Ser Pro Val Gln 
                85                  90                  95      


Gln Gly Leu Gly Gly Gln Ala Gln Gly Gln Pro Asn Ser Ala Asn Met 
            100                 105                 110         


Ala Ser Leu Ser Ala Met Gly Lys Ser Pro Leu Ser Gln Gly Asp Ser 
        115                 120                 125             


Ser Ala Pro Ser Leu Pro Lys Gln Ala Ala Ser Thr Ser Gly Pro Thr 
    130                 135                 140                 


Pro Ala Ala Ser Gln Ala Leu Asn Pro Gln Ala Gln Lys Gln Val Gly 
145                 150                 155                 160 


Leu Ala Thr Ser Ser Pro Ala Thr Ser Gln Thr Gly Pro Gly Ile Cys 
                165                 170                 175     


Met Asn Ala Asn Phe Asn Gln Thr His Pro Gly Leu Leu Asn Ser Asn 
            180                 185                 190         


Ser Gly His Ser Leu Ile Asn Gln Ala Ser Gln Gly Gln Ala Gln Val 
        195                 200                 205             


Met Asn Gly Ser Leu Gly Ala Ala Gly Arg Gly Arg Gly Ala Gly Met 
    210                 215                 220                 


Pro Tyr Pro Thr Pro Ala Met Gln Gly Ala Ser Ser Ser Val Leu Ala 
225                 230                 235                 240 


Glu Thr Leu Thr Gln Val Ser Pro Gln Met Thr Gly His Ala Gly Leu 
                245                 250                 255     


Asn Thr Ala Gln Ala Gly Gly Met Ala Lys Met Gly Ile Thr Gly Asn 
            260                 265                 270         


Thr Ser Pro Phe Gly Gln Pro Phe Ser Gln Ala Gly Gly Gln Pro Met 
        275                 280                 285             


Gly Ala Thr Gly Val Asn Pro Gln Leu Ala Ser Lys Gln Ser Met Val 
    290                 295                 300                 


Asn Ser Leu Pro Thr Phe Pro Thr Asp Ile Lys Asn Thr Ser Val Thr 
305                 310                 315                 320 


Asn Val Pro Asn Met Ser Gln Met Gln Thr Ser Val Gly Ile Val Pro 
                325                 330                 335     


Thr Gln Ala Ile Ala Thr Gly Pro Thr Ala Asp Pro Glu Lys Arg Lys 
            340                 345                 350         


Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln 
        355                 360                 365             


Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Ala Cys Ser Leu Pro His 
    370                 375                 380                 


Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ala 
385                 390                 395                 400 


Gly Lys Ala Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile 
                405                 410                 415     


Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro 
            420                 425                 430         


Leu Lys Asn Ala Ser Asp Lys Arg Asn Gln Gln Thr Ile Leu Gly Ser 
        435                 440                 445             


Pro Ala Ser Gly Ile Gln Asn Thr Ile Gly Ser Val Gly Thr Gly Gln 
    450                 455                 460                 


Gln Asn Ala Thr Ser Leu Ser Asn Pro Asn Pro Ile Asp Pro Ser Ser 
465                 470                 475                 480 


Met Gln Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Met Asn Gln Pro 
                485                 490                 495     


Gln Thr Gln Leu Gln Pro Gln Val Pro Gly Gln Gln Pro Ala Gln Pro 
            500                 505                 510         


Gln Thr His Gln Gln Met Arg Thr Leu Asn Pro Leu Gly Asn Asn Pro 
        515                 520                 525             


Met Asn Ile Pro Ala Gly Gly Ile Thr Thr Asp Gln Gln Pro Pro Asn 
    530                 535                 540                 


Leu Ile Ser Glu Ser Ala Leu Pro Thr Ser Leu Gly Ala Thr Asn Pro 
545                 550                 555                 560 


Leu Met Asn Asp Gly Ser Asn Ser Gly Asn Ile Gly Thr Leu Ser Thr 
                565                 570                 575     


Ile Pro Thr Ala Ala Pro Pro Ser Ser Thr Gly Val Arg Lys Gly Trp 
            580                 585                 590         


His Glu His Val Thr Gln Asp Leu Arg Ser His Leu Val His Lys Leu 
        595                 600                 605             


Val Gln Ala Ile Phe Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg 
    610                 615                 620                 


Arg Met Glu Asn Leu Val Ala Tyr Ala Lys Lys Val Glu Gly Asp Met 
625                 630                 635                 640 


Tyr Glu Ser Ala Asn Ser Arg Asp Glu Tyr Tyr His Leu Leu Ala Glu 
                645                 650                 655     


Lys Ile Tyr Lys Ile Gln Lys Glu Leu Glu Glu Lys Arg Arg Ser Arg 
            660                 665                 670         


Leu His Lys Gln Gly Ile Leu Gly Asn Gln Pro Ala Leu Pro Ala Pro 
        675                 680                 685             


Gly Ala Gln Pro Pro Val Ile Pro Gln Ala Gln Pro Val Arg Pro Pro 
    690                 695                 700                 


Asn Gly Pro Leu Ser Leu Pro Val Asn Arg Met Gln Val Ser Gln Gly 
705                 710                 715                 720 


Met Asn Ser Phe Asn Pro Met Ser Leu Gly Asn Val Gln Leu Pro Gln 
                725                 730                 735     


Ala Pro Met Gly Pro Arg Ala Ala Ser Pro Met Asn His Ser Val Gln 
            740                 745                 750         


Met Asn Ser Met Gly Ser Val Pro Gly Met Ala Ile Ser Pro Ser Arg 
        755                 760                 765             


Met Pro Gln Pro Pro Asn Met Met Gly Ala His Thr Asn Asn Met Met 
    770                 775                 780                 


Ala Gln Ala Pro Ala Gln Ser Gln Phe Leu Pro Gln Asn Gln Phe Pro 
785                 790                 795                 800 


Ser Ser Ser Gly Ala Met Ser Val Gly Met Gly Gln Pro Pro Ala Gln 
                805                 810                 815     


Thr Gly Val Ser Gln Gly Gln Val Pro Gly Ala Ala Leu Pro Asn Pro 
            820                 825                 830         


Leu Asn Met Leu Gly Pro Gln Ala Ser Gln Leu Pro Cys Pro Pro Val 
        835                 840                 845             


Thr Gln Ser Pro Leu His Pro Thr Pro Pro Pro Ala Ser Thr Ala Ala 
    850                 855                 860                 


Gly Met Pro Ser Leu Gln His Thr Thr Pro Pro Gly Met Thr Pro Pro 
865                 870                 875                 880 


Gln Pro Ala Ala Pro Thr Gln Pro Ser Thr Pro Val Ser Ser Ser Gly 
                885                 890                 895     


Gln Thr Pro Thr Pro Thr Pro Gly Ser Val Pro Ser Ala Thr Gln Thr 
            900                 905                 910         


Gln Ser Thr Pro Thr Val Gln Ala Ala Ala Gln Ala Gln Val Thr Pro 
        915                 920                 925             


Gln Pro Gln Thr Pro Val Gln Pro Pro Ser Val Ala Thr Pro Gln Ser 
    930                 935                 940                 


Ser Gln Gln Gln Pro Thr Pro Val His Ala Gln Pro Pro Gly Thr Pro 
945                 950                 955                 960 


Leu Ser Gln Ala Ala Ala Ser Ile Asp Asn Arg Val Pro Thr Pro Ser 
                965                 970                 975     


Ser Val Ala Ser Ala Glu Thr Asn Ser Gln Gln Pro Gly Pro Asp Val 
            980                 985                 990         


Pro Val Leu Glu Met Lys Thr Glu  Thr Gln Ala Glu Asp  Thr Glu Pro 
        995                 1000                 1005             


Asp Pro  Gly Glu Ser Lys Gly  Glu Pro Arg Ser Glu  Met Met Glu 
    1010                 1015                 1020             


Glu Asp  Leu Gln Gly Ala Ser  Gln Val Lys Glu Glu  Thr Asp Ile 
    1025                 1030                 1035             


Ala Glu  Gln Lys Ser Glu Pro  Met Glu Val Asp Glu  Lys Lys Pro 
    1040                 1045                 1050             


Glu Val  Lys Val Glu Val Lys  Glu Glu Glu Glu Ser  Ser Ser Asn 
    1055                 1060                 1065             


Gly Thr  Ala Ser Gln Ser Thr  Ser Pro Ser Gln Pro  Arg Lys Lys 
    1070                 1075                 1080             


Ile Phe  Lys Pro Glu Glu Leu  Arg Gln Ala Leu Met  Pro Thr Leu 
    1085                 1090                 1095             


Glu Ala  Leu Tyr Arg Gln Asp  Pro Glu Ser Leu Pro  Phe Arg Gln 
    1100                 1105                 1110             


Pro Val  Asp Pro Gln Leu Leu  Gly Ile Pro Asp Tyr  Phe Asp Ile 
    1115                 1120                 1125             


Val Lys  Asn Pro Met Asp Leu  Ser Thr Ile Lys Arg  Lys Leu Asp 
    1130                 1135                 1140             


Thr Gly  Gln Tyr Gln Glu Pro  Trp Gln Tyr Val Asp  Asp Val Trp 
    1145                 1150                 1155             


Leu Met  Phe Asn Asn Ala Trp  Leu Tyr Asn Arg Lys  Thr Ser Arg 
    1160                 1165                 1170             


Val Tyr  Lys Phe Cys Ser Lys  Leu Ala Glu Val Phe  Glu Gln Glu 
    1175                 1180                 1185             


Ile Asp  Pro Val Met Gln Ser  Leu Gly Tyr Cys Cys  Gly Arg Lys 
    1190                 1195                 1200             


Tyr Glu  Phe Ser Pro Gln Thr  Leu Cys Cys Tyr Gly  Lys Gln Leu 
    1205                 1210                 1215             


Cys Thr  Ile Pro Arg Asp Ala  Ala Tyr Tyr Ser Tyr  Gln Asn Arg 
    1220                 1225                 1230             


Tyr His  Phe Cys Glu Lys Cys  Phe Thr Glu Ile Gln  Gly Glu Asn 
    1235                 1240                 1245             


Val Thr  Leu Gly Asp Asp Pro  Ser Gln Pro Gln Thr  Thr Ile Ser 
    1250                 1255                 1260             


Lys Asp  Gln Phe Glu Lys Lys  Lys Asn Asp Thr Leu  Asp Pro Glu 
    1265                 1270                 1275             


Pro Phe  Val Asp Cys Lys Glu  Cys Gly Arg Lys Met  His Gln Ile 
    1280                 1285                 1290             


Cys Val  Leu His Tyr Asp Ile  Ile Trp Pro Ser Gly  Phe Val Cys 
    1295                 1300                 1305             


Asp Asn  Cys Leu Lys Lys Thr  Gly Arg Pro Arg Lys  Glu Asn Lys 
    1310                 1315                 1320             


Phe Ser  Ala Lys Arg Leu Gln  Thr Thr Arg Leu Gly  Asn His Leu 
    1325                 1330                 1335             


Glu Asp  Arg Val Asn Lys Phe  Leu Arg Arg Gln Asn  His Pro Glu 
    1340                 1345                 1350             


Ala Gly  Glu Val Phe Val Arg  Val Val Ala Ser Ser  Asp Lys Thr 
    1355                 1360                 1365             


Val Glu  Val Lys Pro Gly Met  Lys Ser Arg Phe Val  Asp Ser Gly 
    1370                 1375                 1380             


Glu Met  Ser Glu Ser Phe Pro  Tyr Arg Thr Lys Ala  Leu Phe Ala 
    1385                 1390                 1395             


Phe Glu  Glu Ile Asp Gly Val  Asp Val Cys Phe Phe  Gly Met His 
    1400                 1405                 1410             


Val Gln  Glu Tyr Gly Ser Asp  Cys Pro Pro Pro Asn  Thr Arg Arg 
    1415                 1420                 1425             


Val Tyr  Ile Ser Tyr Leu Asp  Ser Ile His Phe Phe  Arg Pro Arg 
    1430                 1435                 1440             


Cys Leu  Arg Thr Ala Val Tyr  His Glu Ile Leu Ile  Gly Tyr Leu 
    1445                 1450                 1455             


Glu Tyr  Val Lys Lys Leu Gly  Tyr Val Thr Gly His  Ile Trp Ala 
    1460                 1465                 1470             


Cys Pro  Pro Ser Glu Gly Asp  Asp Tyr Ile Phe His  Cys His Pro 
    1475                 1480                 1485             


Pro Asp  Gln Lys Ile Pro Lys  Pro Lys Arg Leu Gln  Glu Trp Tyr 
    1490                 1495                 1500             


Lys Lys  Met Leu Asp Lys Ala  Phe Ala Glu Arg Ile  Ile His Asp 
    1505                 1510                 1515             


Tyr Lys  Asp Ile Phe Lys Gln  Ala Thr Glu Asp Arg  Leu Thr Ser 
    1520                 1525                 1530             


Ala Lys  Glu Leu Pro Tyr Phe  Glu Gly Asp Phe Trp  Pro Asn Val 
    1535                 1540                 1545             


Leu Glu  Glu Ser Ile Lys Glu  Leu Glu Gln Glu Glu  Glu Glu Arg 
    1550                 1555                 1560             


Lys Lys  Glu Glu Ser Thr Ala  Ala Ser Glu Thr Thr  Glu Gly Ser 
    1565                 1570                 1575             


Gln Gly  Asp Ser Lys Asn Ala  Lys Lys Lys Asn Asn  Lys Lys Thr 
    1580                 1585                 1590             


Asn Lys  Asn Lys Ser Ser Ile  Ser Arg Ala Asn Lys  Lys Lys Pro 
    1595                 1600                 1605             


Ser Met  Pro Asn Val Ser Asn  Asp Leu Ser Gln Lys  Leu Tyr Ala 
    1610                 1615                 1620             


Thr Met  Glu Lys His Lys Glu  Val Phe Phe Val Ile  His Leu His 
    1625                 1630                 1635             


Ala Gly  Pro Val Ile Asn Thr  Leu Pro Pro Ile Val  Asp Pro Asp 
    1640                 1645                 1650             


Pro Leu  Leu Ser Cys Asp Leu  Met Asp Gly Arg Asp  Ala Phe Leu 
    1655                 1660                 1665             


Thr Leu  Ala Arg Asp Lys His  Trp Glu Phe Ser Ser  Leu Arg Arg 
    1670                 1675                 1680             


Ser Lys  Trp Ser Thr Leu Cys  Met Leu Val Glu Leu  His Thr Gln 
    1685                 1690                 1695             


Gly Gln  Asp Arg Phe Val Tyr  Thr Cys Asn Glu Cys  Lys His His 
    1700                 1705                 1710             


Val Glu  Thr Arg Trp His Cys  Thr Val Cys Glu Asp  Tyr Asp Leu 
    1715                 1720                 1725             


Cys Ile  Asn Cys Tyr Asn Thr  Lys Ser His Ala His  Lys Met Val 
    1730                 1735                 1740             


Lys Trp  Gly Leu Gly Leu Asp  Asp Glu Gly Ser Ser  Gln Gly Glu 
    1745                 1750                 1755             


Pro Gln  Ser Lys Ser Pro Gln  Glu Ser Arg Arg Leu  Ser Ile Gln 
    1760                 1765                 1770             


Arg Cys  Ile Gln Ser Leu Val  His Ala Cys Gln Cys  Arg Asn Ala 
    1775                 1780                 1785             


Asn Cys  Ser Leu Pro Ser Cys  Gln Lys Met Lys Arg  Val Val Gln 
    1790                 1795                 1800             


His Thr  Lys Gly Cys Lys Arg  Lys Thr Asn Gly Gly  Cys Pro Val 
    1805                 1810                 1815             


Cys Lys  Gln Leu Ile Ala Leu  Cys Cys Tyr His Ala  Lys His Cys 
    1820                 1825                 1830             


Gln Glu  Asn Lys Cys Pro Val  Pro Phe Cys Leu Asn  Ile Lys His 
    1835                 1840                 1845             


Lys Leu  Arg Gln Gln Gln Ile  Gln His Arg Leu Gln  Gln Ala Gln 
    1850                 1855                 1860             


Leu Met  Arg Arg Arg Met Ala  Thr Met Asn Thr Arg  Asn Val Pro 
    1865                 1870                 1875             


Gln Gln  Ser Leu Pro Ser Pro  Thr Ser Ala Pro Pro  Gly Thr Pro 
    1880                 1885                 1890             


Thr Gln  Gln Pro Ser Thr Pro  Gln Thr Pro Gln Pro  Pro Ala Gln 
    1895                 1900                 1905             


Pro Gln  Pro Ser Pro Val Ser  Met Ser Pro Ala Gly  Phe Pro Ser 
    1910                 1915                 1920             


Val Ala  Arg Thr Gln Pro Pro  Thr Thr Val Ser Thr  Gly Lys Pro 
    1925                 1930                 1935             


Thr Ser  Gln Val Pro Ala Pro  Pro Pro Pro Ala Gln  Pro Pro Pro 
    1940                 1945                 1950             


Ala Ala  Val Glu Ala Ala Arg  Gln Ile Glu Arg Glu  Ala Gln Gln 
    1955                 1960                 1965             


Gln Gln  His Leu Tyr Arg Val  Asn Ile Asn Asn Ser  Met Pro Pro 
    1970                 1975                 1980             


Gly Arg  Thr Gly Met Gly Thr  Pro Gly Ser Gln Met  Ala Pro Val 
    1985                 1990                 1995             


Ser Leu  Asn Val Pro Arg Pro  Asn Gln Val Ser Gly  Pro Val Met 
    2000                 2005                 2010             


Pro Ser  Met Pro Pro Gly Gln  Trp Gln Gln Ala Pro  Leu Pro Gln 
    2015                 2020                 2025             


Gln Gln  Pro Met Pro Gly Leu  Pro Arg Pro Val Ile  Ser Met Gln 
    2030                 2035                 2040             


Ala Gln  Ala Ala Val Ala Gly  Pro Arg Met Pro Ser  Val Gln Pro 
    2045                 2050                 2055             


Pro Arg  Ser Ile Ser Pro Ser  Ala Leu Gln Asp Leu  Leu Arg Thr 
    2060                 2065                 2070             


Leu Lys  Ser Pro Ser Ser Pro  Gln Gln Gln Gln Gln  Val Leu Asn 
    2075                 2080                 2085             


Ile Leu  Lys Ser Asn Pro Gln  Leu Met Ala Ala Phe  Ile Lys Gln 
    2090                 2095                 2100             


Arg Thr  Ala Lys Tyr Val Ala  Asn Gln Pro Gly Met  Gln Pro Gln 
    2105                 2110                 2115             


Pro Gly  Leu Gln Ser Gln Pro  Gly Met Gln Pro Gln  Pro Gly Met 
    2120                 2125                 2130             


His Gln  Gln Pro Ser Leu Gln  Asn Leu Asn Ala Met  Gln Ala Gly 
    2135                 2140                 2145             


Val Pro  Arg Pro Gly Val Pro  Pro Gln Gln Gln Ala  Met Gly Gly 
    2150                 2155                 2160             


Leu Asn  Pro Gln Gly Gln Ala  Leu Asn Ile Met Asn  Pro Gly His 
    2165                 2170                 2175             


Asn Pro  Asn Met Ala Ser Met  Asn Pro Gln Tyr Arg  Glu Met Leu 
    2180                 2185                 2190             


Arg Arg  Gln Leu Leu Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    2195                 2200                 2205             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gly Ser Ala Gly  Met Ala Gly 
    2210                 2215                 2220             


Gly Met  Ala Gly His Gly Gln  Phe Gln Gln Pro Gln  Gly Pro Gly 
    2225                 2230                 2235             


Gly Tyr  Pro Pro Ala Met Gln  Gln Gln Gln Arg Met  Gln Gln His 
    2240                 2245                 2250             


Leu Pro  Leu Gln Gly Ser Ser  Met Gly Gln Met Ala  Ala Gln Met 
    2255                 2260                 2265             


Gly Gln  Leu Gly Gln Met Gly  Gln Pro Gly Leu Gly  Ala Asp Ser 
    2270                 2275                 2280             


Thr Pro  Asn Ile Gln Gln Ala  Leu Gln Gln Arg Ile  Leu Gln Gln 
    2285                 2290                 2295             


Gln Gln  Met Lys Gln Gln Ile  Gly Ser Pro Gly Gln  Pro Asn Pro 
    2300                 2305                 2310             


Met Ser  Pro Gln Gln His Met  Leu Ser Gly Gln Pro  Gln Ala Ser 
    2315                 2320                 2325             


His Leu  Pro Gly Gln Gln Ile  Ala Thr Ser Leu Ser  Asn Gln Val 
    2330                 2335                 2340             


Arg Ser  Pro Ala Pro Val Gln  Ser Pro Arg Pro Gln  Ser Gln Pro 
    2345                 2350                 2355             


Pro His  Ser Ser Pro Ser Pro  Arg Ile Gln Pro Gln  Pro Ser Pro 
    2360                 2365                 2370             


His His  Val Ser Pro Gln Thr  Gly Ser Pro His Pro  Gly Leu Ala 
    2375                 2380                 2385             


Val Thr  Met Ala Ser Ser Ile  Asp Gln Gly His Leu  Gly Asn Pro 
    2390                 2395                 2400             


Glu Gln  Ser Ala Met Leu Pro  Gln Leu Asn Thr Pro  Ser Arg Ser 
    2405                 2410                 2415             


Ala Leu  Ser Ser Glu Leu Ser  Leu Val Gly Asp Thr  Thr Gly Asp 
    2420                 2425                 2430             


Thr Leu  Glu Lys Phe Val Glu  Gly Leu 
    2435                 2440         


<210>  102
<211>  2404
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Ala Glu Asn Leu Leu Asp Gly Pro Pro Asn Pro Lys Arg Ala Lys 
1               5                   10                  15      


Leu Ser Ser Pro Gly Phe Ser Ala Asn Asp Ser Thr Asp Phe Gly Ser 
            20                  25                  30          


Leu Phe Asp Leu Glu Asn Asp Leu Pro Asp Glu Leu Ile Pro Asn Gly 
        35                  40                  45              


Gly Glu Leu Gly Leu Leu Asn Ser Gly Asn Leu Val Pro Asp Ala Ala 
    50                  55                  60                  


Ser Lys His Lys Gln Leu Ser Glu Leu Leu Arg Gly Gly Ser Gly Ser 
65                  70                  75                  80  


Ser Ile Asn Pro Gly Ile Gly Asn Val Ser Ala Ser Ser Pro Val Gln 
                85                  90                  95      


Gln Gly Leu Gly Gly Gln Ala Gln Gly Gln Pro Asn Ser Ala Asn Met 
            100                 105                 110         


Ala Ser Leu Ser Ala Met Gly Lys Ser Pro Leu Ser Gln Gly Asp Ser 
        115                 120                 125             


Ser Ala Pro Ser Leu Pro Lys Gln Ala Ala Ser Thr Ser Gly Pro Thr 
    130                 135                 140                 


Pro Ala Ala Ser Gln Ala Leu Asn Pro Gln Ala Gln Lys Gln Val Gly 
145                 150                 155                 160 


Leu Ala Thr Ser Ser Pro Ala Thr Ser Gln Thr Gly Pro Gly Ile Cys 
                165                 170                 175     


Met Asn Ala Asn Phe Asn Gln Thr His Pro Gly Leu Leu Asn Ser Asn 
            180                 185                 190         


Ser Gly His Ser Leu Ile Asn Gln Ala Ser Gln Gly Gln Ala Gln Val 
        195                 200                 205             


Met Asn Gly Ser Leu Gly Ala Ala Gly Arg Gly Arg Gly Ala Gly Met 
    210                 215                 220                 


Pro Tyr Pro Thr Pro Ala Met Gln Gly Ala Ser Ser Ser Val Leu Ala 
225                 230                 235                 240 


Glu Thr Leu Thr Gln Val Ser Pro Gln Met Thr Gly His Ala Gly Leu 
                245                 250                 255     


Asn Thr Ala Gln Ala Gly Gly Met Ala Lys Met Gly Ile Thr Gly Asn 
            260                 265                 270         


Thr Ser Pro Phe Gly Gln Pro Phe Ser Gln Ala Gly Gly Gln Pro Met 
        275                 280                 285             


Gly Ala Thr Gly Val Asn Pro Gln Leu Ala Ser Lys Gln Ser Met Val 
    290                 295                 300                 


Asn Ser Leu Pro Thr Phe Pro Thr Asp Ile Lys Asn Thr Ser Val Thr 
305                 310                 315                 320 


Asn Val Pro Asn Met Ser Gln Met Gln Thr Ser Val Gly Ile Val Pro 
                325                 330                 335     


Thr Gln Ala Ile Ala Thr Gly Pro Thr Ala Asp Pro Glu Lys Arg Lys 
            340                 345                 350         


Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln 
        355                 360                 365             


Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Ala Cys Ser Leu Pro His 
    370                 375                 380                 


Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ala 
385                 390                 395                 400 


Gly Lys Ala Cys Gln Ala Ile Leu Gly Ser Pro Ala Ser Gly Ile Gln 
                405                 410                 415     


Asn Thr Ile Gly Ser Val Gly Thr Gly Gln Gln Asn Ala Thr Ser Leu 
            420                 425                 430         


Ser Asn Pro Asn Pro Ile Asp Pro Ser Ser Met Gln Arg Ala Tyr Ala 
        435                 440                 445             


Ala Leu Gly Leu Pro Tyr Met Asn Gln Pro Gln Thr Gln Leu Gln Pro 
    450                 455                 460                 


Gln Val Pro Gly Gln Gln Pro Ala Gln Pro Gln Thr His Gln Gln Met 
465                 470                 475                 480 


Arg Thr Leu Asn Pro Leu Gly Asn Asn Pro Met Asn Ile Pro Ala Gly 
                485                 490                 495     


Gly Ile Thr Thr Asp Gln Gln Pro Pro Asn Leu Ile Ser Glu Ser Ala 
            500                 505                 510         


Leu Pro Thr Ser Leu Gly Ala Thr Asn Pro Leu Met Asn Asp Gly Ser 
        515                 520                 525             


Asn Ser Gly Asn Ile Gly Thr Leu Ser Thr Ile Pro Thr Ala Ala Pro 
    530                 535                 540                 


Pro Ser Ser Thr Gly Val Arg Lys Gly Trp His Glu His Val Thr Gln 
545                 550                 555                 560 


Asp Leu Arg Ser His Leu Val His Lys Leu Val Gln Ala Ile Phe Pro 
                565                 570                 575     


Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg Arg Met Glu Asn Leu Val 
            580                 585                 590         


Ala Tyr Ala Lys Lys Val Glu Gly Asp Met Tyr Glu Ser Ala Asn Ser 
        595                 600                 605             


Arg Asp Glu Tyr Tyr His Leu Leu Ala Glu Lys Ile Tyr Lys Ile Gln 
    610                 615                 620                 


Lys Glu Leu Glu Glu Lys Arg Arg Ser Arg Leu His Lys Gln Gly Ile 
625                 630                 635                 640 


Leu Gly Asn Gln Pro Ala Leu Pro Ala Pro Gly Ala Gln Pro Pro Val 
                645                 650                 655     


Ile Pro Gln Ala Gln Pro Val Arg Pro Pro Asn Gly Pro Leu Ser Leu 
            660                 665                 670         


Pro Val Asn Arg Met Gln Val Ser Gln Gly Met Asn Ser Phe Asn Pro 
        675                 680                 685             


Met Ser Leu Gly Asn Val Gln Leu Pro Gln Ala Pro Met Gly Pro Arg 
    690                 695                 700                 


Ala Ala Ser Pro Met Asn His Ser Val Gln Met Asn Ser Met Gly Ser 
705                 710                 715                 720 


Val Pro Gly Met Ala Ile Ser Pro Ser Arg Met Pro Gln Pro Pro Asn 
                725                 730                 735     


Met Met Gly Ala His Thr Asn Asn Met Met Ala Gln Ala Pro Ala Gln 
            740                 745                 750         


Ser Gln Phe Leu Pro Gln Asn Gln Phe Pro Ser Ser Ser Gly Ala Met 
        755                 760                 765             


Ser Val Gly Met Gly Gln Pro Pro Ala Gln Thr Gly Val Ser Gln Gly 
    770                 775                 780                 


Gln Val Pro Gly Ala Ala Leu Pro Asn Pro Leu Asn Met Leu Gly Pro 
785                 790                 795                 800 


Gln Ala Ser Gln Leu Pro Cys Pro Pro Val Thr Gln Ser Pro Leu His 
                805                 810                 815     


Pro Thr Pro Pro Pro Ala Ser Thr Ala Ala Gly Met Pro Ser Leu Gln 
            820                 825                 830         


His Thr Thr Pro Pro Gly Met Thr Pro Pro Gln Pro Ala Ala Pro Thr 
        835                 840                 845             


Gln Pro Ser Thr Pro Val Ser Ser Ser Gly Gln Thr Pro Thr Pro Thr 
    850                 855                 860                 


Pro Gly Ser Val Pro Ser Ala Thr Gln Thr Gln Ser Thr Pro Thr Val 
865                 870                 875                 880 


Gln Ala Ala Ala Gln Ala Gln Val Thr Pro Gln Pro Gln Thr Pro Val 
                885                 890                 895     


Gln Pro Pro Ser Val Ala Thr Pro Gln Ser Ser Gln Gln Gln Pro Thr 
            900                 905                 910         


Pro Val His Ala Gln Pro Pro Gly Thr Pro Leu Ser Gln Ala Ala Ala 
        915                 920                 925             


Ser Ile Asp Asn Arg Val Pro Thr Pro Ser Ser Val Ala Ser Ala Glu 
    930                 935                 940                 


Thr Asn Ser Gln Gln Pro Gly Pro Asp Val Pro Val Leu Glu Met Lys 
945                 950                 955                 960 


Thr Glu Thr Gln Ala Glu Asp Thr Glu Pro Asp Pro Gly Glu Ser Lys 
                965                 970                 975     


Gly Glu Pro Arg Ser Glu Met Met Glu Glu Asp Leu Gln Gly Ala Ser 
            980                 985                 990         


Gln Val Lys Glu Glu Thr Asp Ile  Ala Glu Gln Lys Ser  Glu Pro Met 
        995                 1000                 1005             


Glu Val  Asp Glu Lys Lys Pro  Glu Val Lys Val Glu  Val Lys Glu 
    1010                 1015                 1020             


Glu Glu  Glu Ser Ser Ser Asn  Gly Thr Ala Ser Gln  Ser Thr Ser 
    1025                 1030                 1035             


Pro Ser  Gln Pro Arg Lys Lys  Ile Phe Lys Pro Glu  Glu Leu Arg 
    1040                 1045                 1050             


Gln Ala  Leu Met Pro Thr Leu  Glu Ala Leu Tyr Arg  Gln Asp Pro 
    1055                 1060                 1065             


Glu Ser  Leu Pro Phe Arg Gln  Pro Val Asp Pro Gln  Leu Leu Gly 
    1070                 1075                 1080             


Ile Pro  Asp Tyr Phe Asp Ile  Val Lys Asn Pro Met  Asp Leu Ser 
    1085                 1090                 1095             


Thr Ile  Lys Arg Lys Leu Asp  Thr Gly Gln Tyr Gln  Glu Pro Trp 
    1100                 1105                 1110             


Gln Tyr  Val Asp Asp Val Trp  Leu Met Phe Asn Asn  Ala Trp Leu 
    1115                 1120                 1125             


Tyr Asn  Arg Lys Thr Ser Arg  Val Tyr Lys Phe Cys  Ser Lys Leu 
    1130                 1135                 1140             


Ala Glu  Val Phe Glu Gln Glu  Ile Asp Pro Val Met  Gln Ser Leu 
    1145                 1150                 1155             


Gly Tyr  Cys Cys Gly Arg Lys  Tyr Glu Phe Ser Pro  Gln Thr Leu 
    1160                 1165                 1170             


Cys Cys  Tyr Gly Lys Gln Leu  Cys Thr Ile Pro Arg  Asp Ala Ala 
    1175                 1180                 1185             


Tyr Tyr  Ser Tyr Gln Asn Arg  Tyr His Phe Cys Glu  Lys Cys Phe 
    1190                 1195                 1200             


Thr Glu  Ile Gln Gly Glu Asn  Val Thr Leu Gly Asp  Asp Pro Ser 
    1205                 1210                 1215             


Gln Pro  Gln Thr Thr Ile Ser  Lys Asp Gln Phe Glu  Lys Lys Lys 
    1220                 1225                 1230             


Asn Asp  Thr Leu Asp Pro Glu  Pro Phe Val Asp Cys  Lys Glu Cys 
    1235                 1240                 1245             


Gly Arg  Lys Met His Gln Ile  Cys Val Leu His Tyr  Asp Ile Ile 
    1250                 1255                 1260             


Trp Pro  Ser Gly Phe Val Cys  Asp Asn Cys Leu Lys  Lys Thr Gly 
    1265                 1270                 1275             


Arg Pro  Arg Lys Glu Asn Lys  Phe Ser Ala Lys Arg  Leu Gln Thr 
    1280                 1285                 1290             


Thr Arg  Leu Gly Asn His Leu  Glu Asp Arg Val Asn  Lys Phe Leu 
    1295                 1300                 1305             


Arg Arg  Gln Asn His Pro Glu  Ala Gly Glu Val Phe  Val Arg Val 
    1310                 1315                 1320             


Val Ala  Ser Ser Asp Lys Thr  Val Glu Val Lys Pro  Gly Met Lys 
    1325                 1330                 1335             


Ser Arg  Phe Val Asp Ser Gly  Glu Met Ser Glu Ser  Phe Pro Tyr 
    1340                 1345                 1350             


Arg Thr  Lys Ala Leu Phe Ala  Phe Glu Glu Ile Asp  Gly Val Asp 
    1355                 1360                 1365             


Val Cys  Phe Phe Gly Met His  Val Gln Glu Tyr Gly  Ser Asp Cys 
    1370                 1375                 1380             


Pro Pro  Pro Asn Thr Arg Arg  Val Tyr Ile Ser Tyr  Leu Asp Ser 
    1385                 1390                 1395             


Ile His  Phe Phe Arg Pro Arg  Cys Leu Arg Thr Ala  Val Tyr His 
    1400                 1405                 1410             


Glu Ile  Leu Ile Gly Tyr Leu  Glu Tyr Val Lys Lys  Leu Gly Tyr 
    1415                 1420                 1425             


Val Thr  Gly His Ile Trp Ala  Cys Pro Pro Ser Glu  Gly Asp Asp 
    1430                 1435                 1440             


Tyr Ile  Phe His Cys His Pro  Pro Asp Gln Lys Ile  Pro Lys Pro 
    1445                 1450                 1455             


Lys Arg  Leu Gln Glu Trp Tyr  Lys Lys Met Leu Asp  Lys Ala Phe 
    1460                 1465                 1470             


Ala Glu  Arg Ile Ile His Asp  Tyr Lys Asp Ile Phe  Lys Gln Ala 
    1475                 1480                 1485             


Thr Glu  Asp Arg Leu Thr Ser  Ala Lys Glu Leu Pro  Tyr Phe Glu 
    1490                 1495                 1500             


Gly Asp  Phe Trp Pro Asn Val  Leu Glu Glu Ser Ile  Lys Glu Leu 
    1505                 1510                 1515             


Glu Gln  Glu Glu Glu Glu Arg  Lys Lys Glu Glu Ser  Thr Ala Ala 
    1520                 1525                 1530             


Ser Glu  Thr Thr Glu Gly Ser  Gln Gly Asp Ser Lys  Asn Ala Lys 
    1535                 1540                 1545             


Lys Lys  Asn Asn Lys Lys Thr  Asn Lys Asn Lys Ser  Ser Ile Ser 
    1550                 1555                 1560             


Arg Ala  Asn Lys Lys Lys Pro  Ser Met Pro Asn Val  Ser Asn Asp 
    1565                 1570                 1575             


Leu Ser  Gln Lys Leu Tyr Ala  Thr Met Glu Lys His  Lys Glu Val 
    1580                 1585                 1590             


Phe Phe  Val Ile His Leu His  Ala Gly Pro Val Ile  Asn Thr Leu 
    1595                 1600                 1605             


Pro Pro  Ile Val Asp Pro Asp  Pro Leu Leu Ser Cys  Asp Leu Met 
    1610                 1615                 1620             


Asp Gly  Arg Asp Ala Phe Leu  Thr Leu Ala Arg Asp  Lys His Trp 
    1625                 1630                 1635             


Glu Phe  Ser Ser Leu Arg Arg  Ser Lys Trp Ser Thr  Leu Cys Met 
    1640                 1645                 1650             


Leu Val  Glu Leu His Thr Gln  Gly Gln Asp Arg Phe  Val Tyr Thr 
    1655                 1660                 1665             


Cys Asn  Glu Cys Lys His His  Val Glu Thr Arg Trp  His Cys Thr 
    1670                 1675                 1680             


Val Cys  Glu Asp Tyr Asp Leu  Cys Ile Asn Cys Tyr  Asn Thr Lys 
    1685                 1690                 1695             


Ser His  Ala His Lys Met Val  Lys Trp Gly Leu Gly  Leu Asp Asp 
    1700                 1705                 1710             


Glu Gly  Ser Ser Gln Gly Glu  Pro Gln Ser Lys Ser  Pro Gln Glu 
    1715                 1720                 1725             


Ser Arg  Arg Leu Ser Ile Gln  Arg Cys Ile Gln Ser  Leu Val His 
    1730                 1735                 1740             


Ala Cys  Gln Cys Arg Asn Ala  Asn Cys Ser Leu Pro  Ser Cys Gln 
    1745                 1750                 1755             


Lys Met  Lys Arg Val Val Gln  His Thr Lys Gly Cys  Lys Arg Lys 
    1760                 1765                 1770             


Thr Asn  Gly Gly Cys Pro Val  Cys Lys Gln Leu Ile  Ala Leu Cys 
    1775                 1780                 1785             


Cys Tyr  His Ala Lys His Cys  Gln Glu Asn Lys Cys  Pro Val Pro 
    1790                 1795                 1800             


Phe Cys  Leu Asn Ile Lys His  Lys Leu Arg Gln Gln  Gln Ile Gln 
    1805                 1810                 1815             


His Arg  Leu Gln Gln Ala Gln  Leu Met Arg Arg Arg  Met Ala Thr 
    1820                 1825                 1830             


Met Asn  Thr Arg Asn Val Pro  Gln Gln Ser Leu Pro  Ser Pro Thr 
    1835                 1840                 1845             


Ser Ala  Pro Pro Gly Thr Pro  Thr Gln Gln Pro Ser  Thr Pro Gln 
    1850                 1855                 1860             


Thr Pro  Gln Pro Pro Ala Gln  Pro Gln Pro Ser Pro  Val Ser Met 
    1865                 1870                 1875             


Ser Pro  Ala Gly Phe Pro Ser  Val Ala Arg Thr Gln  Pro Pro Thr 
    1880                 1885                 1890             


Thr Val  Ser Thr Gly Lys Pro  Thr Ser Gln Val Pro  Ala Pro Pro 
    1895                 1900                 1905             


Pro Pro  Ala Gln Pro Pro Pro  Ala Ala Val Glu Ala  Ala Arg Gln 
    1910                 1915                 1920             


Ile Glu  Arg Glu Ala Gln Gln  Gln Gln His Leu Tyr  Arg Val Asn 
    1925                 1930                 1935             


Ile Asn  Asn Ser Met Pro Pro  Gly Arg Thr Gly Met  Gly Thr Pro 
    1940                 1945                 1950             


Gly Ser  Gln Met Ala Pro Val  Ser Leu Asn Val Pro  Arg Pro Asn 
    1955                 1960                 1965             


Gln Val  Ser Gly Pro Val Met  Pro Ser Met Pro Pro  Gly Gln Trp 
    1970                 1975                 1980             


Gln Gln  Ala Pro Leu Pro Gln  Gln Gln Pro Met Pro  Gly Leu Pro 
    1985                 1990                 1995             


Arg Pro  Val Ile Ser Met Gln  Ala Gln Ala Ala Val  Ala Gly Pro 
    2000                 2005                 2010             


Arg Met  Pro Ser Val Gln Pro  Pro Arg Ser Ile Ser  Pro Ser Ala 
    2015                 2020                 2025             


Leu Gln  Asp Leu Leu Arg Thr  Leu Lys Ser Pro Ser  Ser Pro Gln 
    2030                 2035                 2040             


Gln Gln  Gln Gln Val Leu Asn  Ile Leu Lys Ser Asn  Pro Gln Leu 
    2045                 2050                 2055             


Met Ala  Ala Phe Ile Lys Gln  Arg Thr Ala Lys Tyr  Val Ala Asn 
    2060                 2065                 2070             


Gln Pro  Gly Met Gln Pro Gln  Pro Gly Leu Gln Ser  Gln Pro Gly 
    2075                 2080                 2085             


Met Gln  Pro Gln Pro Gly Met  His Gln Gln Pro Ser  Leu Gln Asn 
    2090                 2095                 2100             


Leu Asn  Ala Met Gln Ala Gly  Val Pro Arg Pro Gly  Val Pro Pro 
    2105                 2110                 2115             


Gln Gln  Gln Ala Met Gly Gly  Leu Asn Pro Gln Gly  Gln Ala Leu 
    2120                 2125                 2130             


Asn Ile  Met Asn Pro Gly His  Asn Pro Asn Met Ala  Ser Met Asn 
    2135                 2140                 2145             


Pro Gln  Tyr Arg Glu Met Leu  Arg Arg Gln Leu Leu  Gln Gln Gln 
    2150                 2155                 2160             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    2165                 2170                 2175             


Gly Ser  Ala Gly Met Ala Gly  Gly Met Ala Gly His  Gly Gln Phe 
    2180                 2185                 2190             


Gln Gln  Pro Gln Gly Pro Gly  Gly Tyr Pro Pro Ala  Met Gln Gln 
    2195                 2200                 2205             


Gln Gln  Arg Met Gln Gln His  Leu Pro Leu Gln Gly  Ser Ser Met 
    2210                 2215                 2220             


Gly Gln  Met Ala Ala Gln Met  Gly Gln Leu Gly Gln  Met Gly Gln 
    2225                 2230                 2235             


Pro Gly  Leu Gly Ala Asp Ser  Thr Pro Asn Ile Gln  Gln Ala Leu 
    2240                 2245                 2250             


Gln Gln  Arg Ile Leu Gln Gln  Gln Gln Met Lys Gln  Gln Ile Gly 
    2255                 2260                 2265             


Ser Pro  Gly Gln Pro Asn Pro  Met Ser Pro Gln Gln  His Met Leu 
    2270                 2275                 2280             


Ser Gly  Gln Pro Gln Ala Ser  His Leu Pro Gly Gln  Gln Ile Ala 
    2285                 2290                 2295             


Thr Ser  Leu Ser Asn Gln Val  Arg Ser Pro Ala Pro  Val Gln Ser 
    2300                 2305                 2310             


Pro Arg  Pro Gln Ser Gln Pro  Pro His Ser Ser Pro  Ser Pro Arg 
    2315                 2320                 2325             


Ile Gln  Pro Gln Pro Ser Pro  His His Val Ser Pro  Gln Thr Gly 
    2330                 2335                 2340             


Ser Pro  His Pro Gly Leu Ala  Val Thr Met Ala Ser  Ser Ile Asp 
    2345                 2350                 2355             


Gln Gly  His Leu Gly Asn Pro  Glu Gln Ser Ala Met  Leu Pro Gln 
    2360                 2365                 2370             


Leu Asn  Thr Pro Ser Arg Ser  Ala Leu Ser Ser Glu  Leu Ser Leu 
    2375                 2380                 2385             


Val Gly  Asp Thr Thr Gly Asp  Thr Leu Glu Lys Phe  Val Glu Gly 
    2390                 2395                 2400             


Leu 
    


<210>  103
<211>  254
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  103

Xaa Asp Gly Ser Asn Ser Gly Asn Ile Gly Thr Leu Ser Thr Ile Pro 
1               5                   10                  15      


Thr Ala Ala Pro Pro Ser Ser Thr Gly Val Arg Lys Gly Trp His Glu 
            20                  25                  30          


His Val Thr Gln Asp Leu Arg Ser His Leu Val His Lys Leu Val Gln 
        35                  40                  45              


Ala Ile Phe Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg Arg Met 
    50                  55                  60                  


Glu Asn Leu Val Ala Tyr Ala Lys Lys Val Glu Gly Asp Met Tyr Glu 
65                  70                  75                  80  


Ser Ala Asn Ser Arg Asp Glu Tyr Tyr His Leu Leu Ala Glu Lys Ile 
                85                  90                  95      


Tyr Lys Ile Gln Lys Glu Leu Glu Glu Lys Arg Arg Ser Arg Leu His 
            100                 105                 110         


Lys Gln Gly Ile Leu Gly Asn Gln Pro Ala Leu Pro Ala Pro Gly Ala 
        115                 120                 125             


Gln Pro Pro Val Ile Pro Gln Ala Gln Pro Val Arg Pro Pro Arg Met 
    130                 135                 140                 


Asn Ser Phe Asn Pro Met Ser Leu Gly Asn Val Gln Leu Pro Gln Ala 
145                 150                 155                 160 


Pro Met Gly Pro Arg Ala Ala Ser Pro Met Asn His Ser Val Gln Met 
                165                 170                 175     


Asn Ser Met Gly Ser Val Pro Gly Met Ala Ile Ser Pro Ser Arg Met 
            180                 185                 190         


Pro Gln Pro Pro Asn Met Met Gly Ala His Thr Asn Asn Met Met Ala 
        195                 200                 205             


Gln Ala Pro Ala Gln Ser Gln Phe Leu Pro Gln Asn Gln Phe Pro Ser 
    210                 215                 220                 


Ser Ser Gly Ala Met Ser Val Gly Met Gly Gln Pro Pro Ala Gln Thr 
225                 230                 235                 240 


Gly Val Ser Gln Val Leu Cys Pro Thr Gly Thr Val Ala Pro 
                245                 250                 


<210>  104
<211>  1105
<212>  PRT
<213>  Homo sapiens

<400>  104

Asn Ala Thr Ser Leu Ser Asn Pro Asn Pro Ile Asp Pro Ser Ser Met 
1               5                   10                  15      


Gln Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Met Asn Gln Pro Gln 
            20                  25                  30          


Thr Gln Leu Gln Pro Gln Val Pro Gly Gln Gln Pro Ala Gln Pro Gln 
        35                  40                  45              


Thr His Gln Gln Met Arg Thr Leu Asn Pro Leu Gly Asn Asn Pro Met 
    50                  55                  60                  


Asn Ile Pro Ala Gly Gly Ile Thr Thr Asp Gln Gln Pro Pro Asn Leu 
65                  70                  75                  80  


Ile Ser Glu Ser Ala Leu Pro Thr Ser Leu Gly Ala Thr Asn Pro Leu 
                85                  90                  95      


Met Asn Asp Gly Ser Asn Ser Gly Asn Ile Gly Thr Leu Ser Thr Ile 
            100                 105                 110         


Pro Thr Ala Ala Pro Pro Ser Ser Thr Gly Val Arg Lys Gly Trp His 
        115                 120                 125             


Glu His Val Thr Gln Asp Leu Arg Ser His Leu Val His Lys Leu Val 
    130                 135                 140                 


Gln Ala Ile Phe Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg Arg 
145                 150                 155                 160 


Met Glu Asn Leu Val Ala Tyr Ala Lys Lys Val Glu Gly Asp Met Tyr 
                165                 170                 175     


Glu Ser Ala Asn Ser Arg Asp Glu Tyr Tyr His Leu Leu Ala Glu Lys 
            180                 185                 190         


Ile Tyr Lys Ile Gln Lys Glu Leu Glu Glu Lys Arg Arg Ser Arg Leu 
        195                 200                 205             


His Lys Gln Gly Ile Leu Gly Asn Gln Pro Ala Leu Pro Ala Pro Gly 
    210                 215                 220                 


Ala Gln Pro Pro Val Ile Pro Gln Ala Gln Pro Val Arg Pro Pro Asn 
225                 230                 235                 240 


Gly Pro Leu Ser Leu Pro Val Asn Arg Met Gln Val Ser Gln Gly Met 
                245                 250                 255     


Asn Ser Phe Asn Pro Met Ser Leu Gly Asn Val Gln Leu Pro Gln Ala 
            260                 265                 270         


Pro Met Gly Pro Arg Ala Ala Ser Pro Met Asn His Ser Val Gln Met 
        275                 280                 285             


Asn Ser Met Gly Ser Val Pro Gly Met Ala Ile Ser Pro Ser Arg Met 
    290                 295                 300                 


Pro Gln Pro Pro Asn Met Met Gly Ala His Thr Asn Asn Met Met Ala 
305                 310                 315                 320 


Gln Ala Pro Ala Gln Ser Gln Phe Leu Pro Gln Asn Gln Phe Pro Ser 
                325                 330                 335     


Ser Ser Gly Ala Met Ser Val Gly Met Gly Gln Pro Pro Ala Gln Thr 
            340                 345                 350         


Gly Val Ser Gln Gly Gln Val Pro Gly Ala Ala Leu Pro Asn Pro Leu 
        355                 360                 365             


Asn Met Leu Gly Pro Gln Ala Ser Gln Leu Pro Cys Pro Pro Val Thr 
    370                 375                 380                 


Gln Ser Pro Leu His Pro Thr Pro Pro Pro Ala Ser Thr Ala Ala Gly 
385                 390                 395                 400 


Met Pro Ser Leu Gln His Thr Thr Pro Pro Gly Met Thr Pro Pro Gln 
                405                 410                 415     


Pro Ala Ala Pro Thr Gln Pro Ser Thr Pro Val Ser Ser Ser Gly Gln 
            420                 425                 430         


Thr Pro Thr Pro Thr Pro Gly Ser Val Pro Ser Ala Thr Gln Thr Gln 
        435                 440                 445             


Ser Thr Pro Thr Val Gln Ala Ala Ala Gln Ala Gln Val Thr Pro Gln 
    450                 455                 460                 


Pro Gln Thr Pro Val Gln Pro Pro Ser Val Ala Thr Pro Gln Ser Ser 
465                 470                 475                 480 


Gln Gln Gln Pro Thr Pro Val His Ala Gln Pro Pro Gly Thr Pro Leu 
                485                 490                 495     


Ser Gln Ala Ala Ala Ser Ile Asp Asn Arg Val Pro Thr Pro Ser Ser 
            500                 505                 510         


Val Ala Ser Ala Glu Thr Asn Ser Gln Gln Pro Gly Pro Asp Val Pro 
        515                 520                 525             


Val Leu Glu Met Lys Thr Glu Thr Gln Ala Glu Asp Thr Glu Pro Asp 
    530                 535                 540                 


Pro Gly Glu Ser Lys Gly Glu Pro Arg Ser Glu Met Met Glu Glu Asp 
545                 550                 555                 560 


Leu Gln Gly Ala Ser Gln Val Lys Glu Glu Thr Asp Ile Ala Glu Gln 
                565                 570                 575     


Lys Ser Glu Pro Met Glu Val Asp Glu Lys Lys Pro Glu Val Lys Val 
            580                 585                 590         


Glu Val Lys Glu Glu Glu Glu Ser Ser Ser Asn Gly Thr Ala Ser Gln 
        595                 600                 605             


Ser Thr Ser Pro Ser Gln Pro Arg Lys Lys Ile Phe Lys Pro Glu Glu 
    610                 615                 620                 


Leu Arg Gln Ala Leu Met Pro Thr Leu Glu Ala Leu Tyr Arg Gln Asp 
625                 630                 635                 640 


Pro Glu Ser Leu Pro Phe Arg Gln Pro Val Asp Pro Gln Leu Leu Gly 
                645                 650                 655     


Ile Pro Asp Tyr Phe Asp Ile Val Lys Asn Pro Met Asp Leu Ser Thr 
            660                 665                 670         


Ile Lys Arg Lys Leu Asp Thr Gly Gln Tyr Gln Glu Pro Trp Gln Tyr 
        675                 680                 685             


Val Asp Asp Val Trp Leu Met Phe Asn Asn Ala Trp Leu Tyr Asn Arg 
    690                 695                 700                 


Lys Thr Ser Arg Val Tyr Lys Phe Cys Ser Lys Leu Ala Glu Val Phe 
705                 710                 715                 720 


Glu Gln Glu Ile Asp Pro Val Met Gln Ser Leu Gly Tyr Cys Cys Gly 
                725                 730                 735     


Arg Lys Tyr Glu Phe Ser Pro Gln Thr Leu Cys Cys Tyr Gly Lys Gln 
            740                 745                 750         


Leu Cys Thr Ile Pro Arg Asp Ala Ala Tyr Tyr Ser Tyr Gln Asn Ser 
        755                 760                 765             


Ser Pro Lys Tyr Gly Leu Leu Ala Asp Arg Tyr His Phe Cys Glu Lys 
    770                 775                 780                 


Cys Phe Thr Glu Ile Gln Gly Glu Asn Val Thr Leu Gly Asp Asp Pro 
785                 790                 795                 800 


Ser Gln Pro Gln Thr Thr Ile Ser Lys Asp Gln Phe Glu Lys Lys Lys 
                805                 810                 815     


Asn Asp Thr Leu Asp Pro Glu Pro Phe Val Asp Cys Lys Glu Cys Gly 
            820                 825                 830         


Arg Lys Met His Gln Ile Cys Val Leu His Tyr Asp Ile Ile Trp Pro 
        835                 840                 845             


Ser Gly Phe Val Cys Asp Asn Cys Leu Lys Lys Thr Gly Arg Pro Arg 
    850                 855                 860                 


Lys Glu Asn Lys Phe Ser Ala Lys Arg Leu Gln Thr Thr Arg Leu Gly 
865                 870                 875                 880 


Asn His Leu Glu Asp Arg Val Asn Lys Phe Leu Arg Arg Gln Asn His 
                885                 890                 895     


Pro Glu Ala Gly Glu Val Phe Val Arg Val Val Ala Ser Ser Asp Lys 
            900                 905                 910         


Thr Val Glu Val Lys Pro Gly Met Lys Ser Arg Phe Val Asp Ser Gly 
        915                 920                 925             


Glu Met Ser Glu Ser Phe Pro Tyr Arg Thr Lys Ala Leu Phe Ala Phe 
    930                 935                 940                 


Glu Glu Ile Asp Gly Val Asp Val Cys Phe Phe Gly Met His Val Gln 
945                 950                 955                 960 


Glu Tyr Gly Ser Asp Cys Pro Pro Pro Asn Thr Arg Arg Val Tyr Ile 
                965                 970                 975     


Ser Tyr Leu Asp Ser Ile His Phe Phe Arg Pro Arg Cys Leu Arg Thr 
            980                 985                 990         


Ala Val Tyr His Glu Ile Leu Ile  Gly Tyr Leu Glu Tyr  Val Lys Lys 
        995                 1000                 1005             


Leu Gly  Tyr Val Thr Gly His  Ile Trp Ala Cys Pro  Pro Ser Glu 
    1010                 1015                 1020             


Gly Asp  Asp Tyr Ile Phe His  Cys His Pro Pro Asp  Gln Lys Ile 
    1025                 1030                 1035             


Pro Lys  Pro Lys Arg Leu Gln  Glu Trp Tyr Lys Lys  Met Leu Asp 
    1040                 1045                 1050             


Lys Ala  Phe Ala Glu Arg Ile  Ile His Asp Tyr Lys  Asp Ile Phe 
    1055                 1060                 1065             


Lys Gln  Ala Thr Glu Asp Arg  Leu Thr Ser Ala Lys  Glu Leu Pro 
    1070                 1075                 1080             


Tyr Phe  Glu Gly Asp Phe Trp  Pro Asn Val Leu Glu  Glu Ser Ile 
    1085                 1090                 1095             


Lys Glu  Leu Glu Gln Glu Glu  
    1100                 1105 


<210>  105
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  105

Xaa Thr Cys Asn Glu Cys Lys His His Val Glu Thr Arg Trp His Cys 
1               5                   10                  15      


Thr Val Cys Glu Phe Leu Asn Ala Ala Val Phe Ile Ser Phe Cys Glu 
            20                  25                  30          


His 
    


<210>  106
<211>  196
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  106

Xaa Arg Tyr His Phe Cys Glu Lys Cys Phe Thr Glu Ile Gln Gly Glu 
1               5                   10                  15      


Asn Val Thr Leu Gly Asp Asp Pro Ser Gln Pro Gln Thr Thr Ile Ser 
            20                  25                  30          


Lys Asp Gln Phe Glu Lys Lys Lys Asn Asp Thr Leu Asp Pro Glu Pro 
        35                  40                  45              


Phe Val Asp Cys Lys Glu Cys Gly Arg Lys Met His Gln Ile Cys Val 
    50                  55                  60                  


Leu His Tyr Asp Ile Ile Trp Pro Ser Gly Phe Val Cys Asp Asn Cys 
65                  70                  75                  80  


Leu Lys Lys Thr Gly Arg Pro Arg Lys Glu Asn Lys Phe Ser Ala Lys 
                85                  90                  95      


Arg Leu Gln Thr Thr Arg Leu Gly Asn His Leu Glu Asp Arg Val Asn 
            100                 105                 110         


Lys Phe Leu Arg Arg Gln Asn His Pro Glu Ala Gly Glu Val Phe Val 
        115                 120                 125             


Arg Val Val Ala Ser Ser Asp Lys Thr Val Glu Val Lys Pro Gly Met 
    130                 135                 140                 


Lys Ser Arg Phe Val Asp Ser Gly Glu Met Ser Glu Ser Phe Pro Tyr 
145                 150                 155                 160 


Arg Thr Lys Ala Leu Phe Ala Phe Glu Glu Ile Asp Gly Val Asp Val 
                165                 170                 175     


Cys Phe Phe Gly Met His Val Gln Glu Tyr Gly Ser Asp Cys Pro Pro 
            180                 185                 190         


Pro Asn Thr Arg 
        195     


<210>  107
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  107

Xaa His Leu Leu Ala Glu Lys Ile Tyr Lys Ile Gln Lys Glu Leu Glu 
1               5                   10                  15      


Glu Lys Arg Arg Ser Arg Leu His Lys Gln Gly Ile Leu Gly Asn Gln 
            20                  25                  30          


Pro Ala Leu Pro Ala Pro Gly Ala Gln Pro Pro Val Ile Pro Gln Ala 
        35                  40                  45              


Gln Pro Val Arg Pro Pro Asn Gly Pro Leu Ser Leu Pro Val Asn Arg 
    50                  55                  60                  


Met Gln Val Ser Gln Gly Met Asn Ser Phe Asn Pro Met Ser Leu Gly 
65                  70                  75                  80  


Asn Val Gln Leu Pro Gln Ala Pro Met Gly Pro Arg Ala Ala Ser Pro 
                85                  90                  95      


Met Asn His Ser Val Gln Met Asn Ser Met Gly Ser Val Pro Gly Met 
            100                 105                 110         


Ala Ile Ser Pro Ser Arg Met Pro Gln Pro Pro Asn Met Met Gly Ala 
        115                 120                 125             


His Thr Asn Asn Met Met Ala Gln Ala Pro Ala Gln Ser Gln Phe Leu 
    130                 135                 140                 


Pro Gln Asn Gln Phe Pro Ser Ser Ser Gly Ala Met Ser Val Gly Met 
145                 150                 155                 160 


Gly Gln Pro Pro Ala Gln Thr Gly Val Ser Gln Val Leu Cys Pro Thr 
                165                 170                 175     


Gly Thr Val Ala Pro 
            180     


<210>  108
<211>  693
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Asp Arg Pro Asp Glu Gly Pro Pro Ala Lys Thr Arg Arg Leu Ser 
1               5                   10                  15      


Ser Ser Glu Ser Pro Gln Arg Asp Pro Pro Pro Pro Pro Pro Pro Pro 
            20                  25                  30          


Pro Leu Leu Arg Leu Pro Leu Pro Pro Pro Gln Gln Arg Pro Arg Leu 
        35                  40                  45              


Gln Glu Glu Thr Glu Ala Ala Gln Val Leu Ala Asp Met Arg Gly Val 
    50                  55                  60                  


Gly Leu Gly Pro Ala Leu Pro Pro Pro Pro Pro Tyr Val Ile Leu Glu 
65                  70                  75                  80  


Glu Gly Gly Ile Arg Ala Tyr Phe Thr Leu Gly Ala Glu Cys Pro Gly 
                85                  90                  95      


Trp Asp Ser Thr Ile Glu Ser Gly Tyr Gly Glu Ala Pro Pro Pro Thr 
            100                 105                 110         


Glu Ser Leu Glu Ala Leu Pro Thr Pro Glu Ala Ser Gly Gly Ser Leu 
        115                 120                 125             


Glu Ile Asp Phe Gln Val Val Gln Ser Ser Ser Phe Gly Gly Glu Gly 
    130                 135                 140                 


Ala Leu Glu Thr Cys Ser Ala Val Gly Trp Ala Pro Gln Arg Leu Val 
145                 150                 155                 160 


Asp Pro Lys Ser Lys Glu Glu Ala Ile Ile Ile Val Glu Asp Glu Asp 
                165                 170                 175     


Glu Asp Glu Arg Glu Ser Met Arg Ser Ser Arg Arg Arg Arg Arg Arg 
            180                 185                 190         


Arg Arg Arg Lys Gln Arg Lys Val Lys Arg Glu Ser Arg Glu Arg Asn 
        195                 200                 205             


Ala Glu Arg Met Glu Ser Ile Leu Gln Ala Leu Glu Asp Ile Gln Leu 
    210                 215                 220                 


Asp Leu Glu Ala Val Asn Ile Lys Ala Gly Lys Ala Phe Leu Arg Leu 
225                 230                 235                 240 


Lys Arg Lys Phe Ile Gln Met Arg Arg Pro Phe Leu Glu Arg Arg Asp 
                245                 250                 255     


Leu Ile Ile Gln His Ile Pro Gly Phe Trp Val Lys Ala Phe Leu Asn 
            260                 265                 270         


His Pro Arg Ile Ser Ile Leu Ile Asn Arg Arg Asp Glu Asp Ile Phe 
        275                 280                 285             


Arg Tyr Leu Thr Asn Leu Gln Val Gln Asp Leu Arg His Ile Ser Met 
    290                 295                 300                 


Gly Tyr Lys Met Lys Leu Tyr Phe Gln Thr Asn Pro Tyr Phe Thr Asn 
305                 310                 315                 320 


Met Val Ile Val Lys Glu Phe Gln Arg Asn Arg Ser Gly Arg Leu Val 
                325                 330                 335     


Ser His Ser Thr Pro Ile Arg Trp His Arg Gly Gln Glu Pro Gln Ala 
            340                 345                 350         


Arg Arg His Gly Asn Gln Asp Ala Ser His Ser Phe Phe Ser Trp Phe 
        355                 360                 365             


Ser Asn His Ser Leu Pro Glu Ala Asp Arg Ile Ala Glu Ile Ile Lys 
    370                 375                 380                 


Asn Asp Leu Trp Val Asn Pro Leu Arg Tyr Tyr Leu Arg Glu Arg Gly 
385                 390                 395                 400 


Ser Arg Ile Lys Arg Lys Lys Gln Glu Met Lys Lys Arg Lys Thr Arg 
                405                 410                 415     


Gly Arg Cys Glu Val Val Ile Met Glu Asp Ala Pro Asp Tyr Tyr Ala 
            420                 425                 430         


Val Glu Asp Ile Phe Ser Glu Ile Ser Asp Ile Asp Glu Thr Ile His 
        435                 440                 445             


Asp Ile Lys Ile Ser Asp Phe Met Glu Thr Thr Asp Tyr Phe Glu Thr 
    450                 455                 460                 


Thr Asp Asn Glu Ile Thr Asp Ile Asn Glu Asn Ile Cys Asp Ser Glu 
465                 470                 475                 480 


Asn Pro Asp His Asn Glu Val Pro Asn Asn Glu Thr Thr Asp Asn Asn 
                485                 490                 495     


Glu Ser Ala Asp Asp His Glu Thr Thr Asp Asn Asn Glu Ser Ala Asp 
            500                 505                 510         


Asp Asn Asn Glu Asn Pro Glu Asp Asn Asn Lys Asn Thr Asp Asp Asn 
        515                 520                 525             


Glu Glu Asn Pro Asn Asn Asn Glu Asn Thr Tyr Gly Asn Asn Phe Phe 
    530                 535                 540                 


Lys Gly Gly Phe Trp Gly Ser His Gly Asn Asn Gln Asp Ser Ser Asp 
545                 550                 555                 560 


Ser Asp Asn Glu Ala Asp Glu Ala Ser Asp Asp Glu Asp Asn Asp Gly 
                565                 570                 575     


Asn Glu Gly Asp Asn Glu Gly Ser Asp Asp Asp Gly Asn Glu Gly Asp 
            580                 585                 590         


Asn Glu Gly Ser Asp Asp Asp Asp Arg Asp Ile Glu Tyr Tyr Glu Lys 
        595                 600                 605             


Val Ile Glu Asp Phe Asp Lys Asp Gln Ala Asp Tyr Glu Asp Val Ile 
    610                 615                 620                 


Glu Ile Ile Ser Asp Glu Ser Val Glu Glu Glu Gly Ile Glu Glu Gly 
625                 630                 635                 640 


Ile Gln Gln Asp Glu Asp Ile Tyr Glu Glu Gly Asn Tyr Glu Glu Glu 
                645                 650                 655     


Gly Ser Glu Asp Val Trp Glu Glu Gly Glu Asp Ser Asp Asp Ser Asp 
            660                 665                 670         


Leu Glu Asp Val Leu Gln Val Pro Asn Gly Trp Ala Asn Pro Gly Lys 
        675                 680                 685             


Arg Gly Lys Thr Gly 
    690             


<210>  109
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  109

Xaa Glu Glu Ala Ile Ile Ile Val Glu Asp Glu Asp Glu Asp Glu Arg 
1               5                   10                  15      


Glu Ser Met Arg Ser Ser Arg Arg Arg Arg Arg Arg Arg Arg Arg Lys 
            20                  25                  30          


Gln Arg Lys Val Lys Arg Glu Ser Arg Glu Arg Asn Ala Glu Arg Met 
        35                  40                  45              


Glu Ser Ile Leu Gln Ala Leu Glu Asp Ile Gln Leu Asp Leu Glu Ala 
    50                  55                  60                  


Val Asn Ile Lys Ala Gly Lys Ala Phe Leu Arg Leu Lys Arg Lys Phe 
65                  70                  75                  80  


Ile Gln Met Arg Arg Pro Phe Leu Glu Arg Arg Asp Leu Ile Ile Gln 
                85                  90                  95      


His Ile Pro Gly Phe Trp Val Lys Ala Leu His Ser Ser Val Pro Gln 
            100                 105                 110         


Pro Pro Gln Asn Phe Asn Phe Asp Gln Pro Thr 
        115                 120             


<210>  110
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Asp Arg Pro Asp Glu Gly Pro Pro Ala Lys Thr Arg Arg Leu Ser 
1               5                   10                  15      


Ser Ser Glu Ser Pro Gln Arg Asp Pro Pro Pro Pro Pro Pro Pro Pro 
            20                  25                  30          


Pro Leu Leu Arg Leu Pro Leu Pro Pro Pro Gln Gln Arg Pro Arg Leu 
        35                  40                  45              


Gln Glu Glu Thr Glu Ala Ala Gln Ile Ile Lys Asn Asp Leu Trp Val 
    50                  55                  60                  


Asn Pro Leu Arg Tyr Tyr Leu Arg Glu Arg Gly Ser Arg Ile Lys Arg 
65                  70                  75                  80  


Lys Lys Gln Glu Met Lys Lys Arg Lys Thr Arg Gly Arg Cys Glu Val 
                85                  90                  95      


Val Ile Met Glu Asp Ala Pro Asp Tyr Tyr Ala Val Glu Asp Ile Phe 
            100                 105                 110         


Ser Glu Ile Ser Asp Ile Asp Glu Thr Ile His Asp Ile Lys Ile Ser 
        115                 120                 125             


Asp Phe Met Glu Thr Thr Asp Tyr Phe Glu Thr Thr Asp Asn Glu Ile 
    130                 135                 140                 


Thr Asp Ile Asn Glu Asn Ile Cys Asp Ser Glu Asn Pro Asp His Asn 
145                 150                 155                 160 


Glu Val Pro Asn Asn Glu Thr Thr Asp Asn Asn Glu Ser Ala Asp Asp 
                165                 170                 175     


His Glu Thr Thr Asp Asn Asn Glu Ser Ala Asp Asp Asn Asn Glu Asn 
            180                 185                 190         


Pro Glu Asp Asn Asn Lys Asn Thr Asp Asp Asn Glu Glu Asn Pro Asn 
        195                 200                 205             


Asn Asn Glu Asn Thr Tyr Gly Asn Asn Phe Phe Lys Gly Gly Phe Trp 
    210                 215                 220                 


Gly Ser His Gly Asn Asn Gln Asp Ser Ser Asp Ser Asp Asn Glu Ala 
225                 230                 235                 240 


Asp Glu Ala Ser Asp Asp Glu Asp Asn Asp 
                245                 250 


<210>  111
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Ala Gly Gly Val Asp Gly Pro Ile Gly Ile Pro Phe Pro Asp His 
1               5                   10                  15      


Ser Ser Asp Ile Leu Ser Gly Leu Asn Glu Gln Arg Thr Gln Gly Leu 
            20                  25                  30          


Leu Cys Asp Val Val Ile Leu Val Glu Gly Arg Glu Phe Pro Thr His 
        35                  40                  45              


Arg Ser Val Leu Ala Ala Cys Ser Gln Tyr Phe Lys Lys Leu Phe Thr 
    50                  55                  60                  


Ser Gly Ala Val Val Asp Gln Gln Asn Val Tyr Glu Ile Asp Phe Val 
65                  70                  75                  80  


Ser Ala Glu Ala Leu Thr Ala Leu Met Asp Phe Ala Tyr Thr Ala Thr 
                85                  90                  95      


Leu Thr Val Ser Thr Ala Asn Val Gly Asp Ile Leu Ser Ala Ala Arg 
            100                 105                 110         


Leu Leu Glu Ile Pro Ala Val Ser His Val Cys Ala Asp Leu Leu Asp 
        115                 120                 125             


Arg Gln Ile Leu Ala Ala Asp Ala Gly Ala Asp Ala Gly Gln Leu Asp 
    130                 135                 140                 


Leu Val Asp Gln Ile Asp Gln Arg Asn Leu Leu Arg Ala Lys Glu Tyr 
145                 150                 155                 160 


Leu Glu Phe Phe Gln Ser Asn Pro Met Asn Ser Leu Pro Pro Ala Ala 
                165                 170                 175     


Ala Ala Ala Ala Ala Ser Phe Pro Trp Ser Ala Phe Gly Ala Ser Asp 
            180                 185                 190         


Asp Asp Leu Asp Ala Thr Lys Glu Ala Val Ala Ala Ala Val Ala Ala 
        195                 200                 205             


Val Ala Ala Gly Asp Cys Asn Gly Leu Asp Phe Tyr Gly Pro Gly Pro 
    210                 215                 220                 


Pro Ala Glu Arg Pro Pro Thr Gly Asp Gly Asp Glu Gly Asp Ser Asn 
225                 230                 235                 240 


Pro Gly Leu Trp Pro Glu Arg Asp Glu Asp Ala Pro Thr Gly Gly Leu 
                245                 250                 255     


Phe Pro Pro Pro Val Ala Pro Pro Ala Ala Thr Gln Asn Gly His Tyr 
            260                 265                 270         


Gly Arg Gly Gly Glu Glu Glu Ala Ala Ser Leu Ser Glu Ala Ala Pro 
        275                 280                 285             


Glu Pro Gly Asp Ser Pro Gly Phe Leu Ser Gly Ala Ala Glu Gly Glu 
    290                 295                 300                 


Asp Gly Asp Gly Pro Asp Val Asp Gly Leu Ala Ala Ser Thr Leu Leu 
305                 310                 315                 320 


Gln Gln Met Met Ser Ser Val Gly Arg Ala Gly Ala Ala Ala Gly Asp 
                325                 330                 335     


Ser Asp Glu Glu Ser Arg Ala Asp Asp Lys Gly Val Met Asp Tyr Tyr 
            340                 345                 350         


Leu Lys Tyr Phe Ser Gly Ala His Asp Gly Asp Val Tyr Pro Ala Trp 
        355                 360                 365             


Ser Gln Lys Val Glu Lys Lys Ile Arg Ala Lys Ala Phe Gln Lys Cys 
    370                 375                 380                 


Pro Ile Cys Glu Lys Val Ile Gln Gly Ala Gly Lys Leu Pro Arg His 
385                 390                 395                 400 


Ile Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Ile Cys Lys 
                405                 410                 415     


Val Arg Phe Thr Arg Gln Asp Lys Leu Lys Val His Met Arg Lys His 
            420                 425                 430         


Thr Gly Glu Lys Pro Tyr Leu Cys Gln Gln Cys Gly Ala Ala Phe Ala 
        435                 440                 445             


His Asn Tyr Asp Leu Lys Asn His Met Arg Val His Thr Gly Leu Arg 
    450                 455                 460                 


Pro Tyr Gln Cys Asp Ser Cys Cys Lys Thr Phe Val Arg Ser Asp His 
465                 470                 475                 480 


Leu His Arg His Leu Lys Lys Asp Gly Cys Asn Gly Val Pro Ser Arg 
                485                 490                 495     


Arg Gly Arg Lys Pro Arg Val Arg Gly Gly Ala Pro Asp Pro Ser Pro 
            500                 505                 510         


Gly Ala Thr Ala Thr Pro Gly Ala Pro Ala Gln Pro Ser Ser Pro Asp 
        515                 520                 525             


Ala Arg Arg Asn Gly Gln Glu Lys His Phe Lys Asp Glu Asp Glu Asp 
    530                 535                 540                 


Glu Asp Val Ala Ser Pro Asp Gly Leu Gly Arg Leu Asn Val Ala Gly 
545                 550                 555                 560 


Ala Gly Gly Gly Gly Asp Ser Gly Gly Gly Pro Gly Ala Ala Thr Asp 
                565                 570                 575     


Gly Asn Phe Thr Ala Gly Leu Ala 
            580                 


<210>  112
<211>  747
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Ala Asp Glu Ala Ala Leu Ala Leu Gln Pro Gly Gly Ser Pro Ser 
1               5                   10                  15      


Ala Ala Gly Ala Asp Arg Glu Ala Ala Ser Ser Pro Ala Gly Glu Pro 
            20                  25                  30          


Leu Arg Lys Arg Pro Arg Arg Asp Gly Pro Gly Leu Glu Arg Ser Pro 
        35                  40                  45              


Gly Glu Pro Gly Gly Ala Ala Pro Glu Arg Glu Val Pro Ala Ala Ala 
    50                  55                  60                  


Arg Gly Cys Pro Gly Ala Ala Ala Ala Ala Leu Trp Arg Glu Ala Glu 
65                  70                  75                  80  


Ala Glu Ala Ala Ala Ala Gly Gly Glu Gln Glu Ala Gln Ala Thr Ala 
                85                  90                  95      


Ala Ala Gly Glu Gly Asp Asn Gly Pro Gly Leu Gln Gly Pro Ser Arg 
            100                 105                 110         


Glu Pro Pro Leu Ala Asp Asn Leu Tyr Asp Glu Asp Asp Asp Asp Glu 
        115                 120                 125             


Gly Glu Glu Glu Glu Glu Ala Ala Ala Ala Ala Ile Gly Tyr Arg Asp 
    130                 135                 140                 


Asn Leu Leu Phe Gly Asp Glu Ile Ile Thr Asn Gly Phe His Ser Cys 
145                 150                 155                 160 


Glu Ser Asp Glu Glu Asp Arg Ala Ser His Ala Ser Ser Ser Asp Trp 
                165                 170                 175     


Thr Pro Arg Pro Arg Ile Gly Pro Tyr Thr Phe Val Gln Gln His Leu 
            180                 185                 190         


Met Ile Gly Thr Asp Pro Arg Thr Ile Leu Lys Asp Leu Leu Pro Glu 
        195                 200                 205             


Thr Ile Pro Pro Pro Glu Leu Asp Asp Met Thr Leu Trp Gln Ile Val 
    210                 215                 220                 


Ile Asn Ile Leu Ser Glu Pro Pro Lys Arg Lys Lys Arg Lys Asp Ile 
225                 230                 235                 240 


Asn Thr Ile Glu Asp Ala Val Lys Leu Leu Gln Glu Cys Lys Lys Ile 
                245                 250                 255     


Ile Val Leu Thr Gly Ala Gly Val Ser Val Ser Cys Gly Ile Pro Asp 
            260                 265                 270         


Phe Arg Ser Arg Asp Gly Ile Tyr Ala Arg Leu Ala Val Asp Phe Pro 
        275                 280                 285             


Asp Leu Pro Asp Pro Gln Ala Met Phe Asp Ile Glu Tyr Phe Arg Lys 
    290                 295                 300                 


Asp Pro Arg Pro Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln 
305                 310                 315                 320 


Phe Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys Glu 
                325                 330                 335     


Gly Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln 
            340                 345                 350         


Val Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala Thr 
        355                 360                 365             


Ala Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val Arg 
    370                 375                 380                 


Gly Asp Ile Phe Asn Gln Val Val Pro Arg Cys Pro Arg Cys Pro Ala 
385                 390                 395                 400 


Asp Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly Glu 
                405                 410                 415     


Asn Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp Glu 
            420                 425                 430         


Val Asp Leu Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg Pro Val 
        435                 440                 445             


Ala Leu Ile Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile Leu Ile 
    450                 455                 460                 


Asn Arg Glu Pro Leu Pro His Leu His Phe Asp Val Glu Leu Leu Gly 
465                 470                 475                 480 


Asp Cys Asp Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly Gly Glu 
                485                 490                 495     


Tyr Ala Lys Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile Thr Glu 
            500                 505                 510         


Lys Pro Pro Arg Thr Gln Lys Glu Leu Ala Tyr Leu Ser Glu Leu Pro 
        515                 520                 525             


Pro Thr Pro Leu His Val Ser Glu Asp Ser Ser Ser Pro Glu Arg Thr 
    530                 535                 540                 


Ser Pro Pro Asp Ser Ser Val Ile Val Thr Leu Leu Asp Gln Ala Ala 
545                 550                 555                 560 


Lys Ser Asn Asp Asp Leu Asp Val Ser Glu Ser Lys Gly Cys Met Glu 
                565                 570                 575     


Glu Lys Pro Gln Glu Val Gln Thr Ser Arg Asn Val Glu Ser Ile Ala 
            580                 585                 590         


Glu Gln Met Glu Asn Pro Asp Leu Lys Asn Val Gly Ser Ser Thr Gly 
        595                 600                 605             


Glu Lys Asn Glu Arg Thr Ser Val Ala Gly Thr Val Arg Lys Cys Trp 
    610                 615                 620                 


Pro Asn Arg Val Ala Lys Glu Gln Ile Ser Arg Arg Leu Asp Gly Asn 
625                 630                 635                 640 


Gln Tyr Leu Phe Leu Pro Pro Asn Arg Tyr Ile Phe His Gly Ala Glu 
                645                 650                 655     


Val Tyr Ser Asp Ser Glu Asp Asp Val Leu Ser Ser Ser Ser Cys Gly 
            660                 665                 670         


Ser Asn Ser Asp Ser Gly Thr Cys Gln Ser Pro Ser Leu Glu Glu Pro 
        675                 680                 685             


Met Glu Asp Glu Ser Glu Ile Glu Glu Phe Tyr Asn Gly Leu Glu Asp 
    690                 695                 700                 


Glu Pro Asp Val Pro Glu Arg Ala Gly Gly Ala Gly Phe Gly Thr Asp 
705                 710                 715                 720 


Gly Asp Asp Gln Glu Ala Ile Asn Glu Ala Ile Ser Val Lys Gln Glu 
                725                 730                 735     


Val Thr Asp Met Asn Tyr Pro Ser Asn Lys Ser 
            740                 745         


<210>  113
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Cys Leu Cys Ser Gly Arg Lys Thr Ile Leu Glu Ile Tyr Pro Gly 
1               5                   10                  15      


Gln Phe Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys 
            20                  25                  30          


Glu Gly Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu 
        35                  40                  45              


Gln Val Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala 
    50                  55                  60                  


Thr Ala Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val 
65                  70                  75                  80  


Arg Gly Asp Ile Phe Asn Gln Val Val Pro Arg Cys Pro Arg Cys Pro 
                85                  90                  95      


Ala Asp Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly 
            100                 105                 110         


Glu Asn Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp 
        115                 120                 125             


Glu Val Asp Leu Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg Pro 
    130                 135                 140                 


Val Ala Leu Ile Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile Leu 
145                 150                 155                 160 


Ile Asn Arg Glu Pro Leu Pro His Leu His Phe Asp Val Glu Leu Leu 
                165                 170                 175     


Gly Asp Cys Asp Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly Gly 
            180                 185                 190         


Glu Tyr Ala Lys Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile Thr 
        195                 200                 205             


Glu Lys Pro Pro Arg Thr Gln Lys Glu Leu Ala Tyr Leu Ser Glu Leu 
    210                 215                 220                 


Pro Pro Thr Pro Leu His Val Ser Glu Asp Ser Ser Ser Pro Glu Arg 
225                 230                 235                 240 


Thr Ser Pro Pro Asp Ser Ser Val Ile Val Thr Leu Leu Asp Gln Ala 
                245                 250                 255     


Ala Lys Ser Asn Asp Asp Leu Asp Val Ser Glu Ser Lys Gly Cys Met 
            260                 265                 270         


Glu Glu Lys Pro Gln Glu Val Gln Thr Ser Arg Asn Val Glu Ser Ile 
        275                 280                 285             


Ala Glu Gln Met Glu Asn Pro Asp Leu Lys Asn Val Gly Ser Ser Thr 
    290                 295                 300                 


Gly Glu Lys Asn Glu Arg Thr Ser Val Ala Gly Thr Val Arg Lys Cys 
305                 310                 315                 320 


Trp Pro Asn Arg Val Ala Lys Glu Gln Ile Ser Arg Arg Leu Asp Gly 
                325                 330                 335     


Asn Gln Tyr Leu Phe Leu Pro Pro Asn Arg Tyr Ile Phe His Gly Ala 
            340                 345                 350         


Glu Val Tyr Ser Asp Ser Glu Asp Asp Val Leu Ser Ser Ser Ser Cys 
        355                 360                 365             


Gly Ser Asn Ser Asp Ser Gly Thr Cys Gln Ser Pro Ser Leu Glu Glu 
    370                 375                 380                 


Pro Met Glu Asp Glu Ser Glu Ile Glu Glu Phe Tyr Asn Gly Leu Glu 
385                 390                 395                 400 


Asp Glu Pro Asp Val Pro Glu Arg Ala Gly Gly Ala Gly Phe Gly Thr 
                405                 410                 415     


Asp Gly Asp Asp Gln Glu Ala Ile Asn Glu Ala Ile Ser Val Lys Gln 
            420                 425                 430         


Glu Val Thr Asp Met Asn Tyr Pro Ser Asn Lys Ser 
        435                 440                 


<210>  114
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Phe Asp Ile Glu Tyr Phe Arg Lys Asp Pro Arg Pro Phe Phe Lys 
1               5                   10                  15      


Phe Ala Lys Glu Ile Tyr Pro Gly Gln Phe Gln Pro Ser Leu Cys His 
            20                  25                  30          


Lys Phe Ile Ala Leu Ser Asp Lys Glu Gly Lys Leu Leu Arg Asn Tyr 
        35                  40                  45              


Thr Gln Asn Ile Asp Thr Leu Glu Gln Val Ala Gly Ile Gln Arg Ile 
    50                  55                  60                  


Ile Gln Cys His Gly Ser Phe Ala Thr Ala Ser Cys Leu Ile Cys Lys 
65                  70                  75                  80  


Tyr Lys Val Asp Cys Glu Ala Val Arg Gly Asp Ile Phe Asn Gln Val 
                85                  90                  95      


Val Pro Arg Cys Pro Arg Cys Pro Ala Asp Glu Pro Leu Ala Ile Met 
            100                 105                 110         


Lys Pro Glu Ile Val Phe Phe Gly Glu Asn Leu Pro Glu Gln Phe His 
        115                 120                 125             


Arg Ala Met Lys Tyr Asp Lys Asp Glu Val Asp Leu Leu Ile Val Ile 
    130                 135                 140                 


Gly Ser Ser Leu Lys Val Arg Pro Val Ala Leu Ile Pro Ser Ser Ile 
145                 150                 155                 160 


Pro His Glu Val Pro Gln Ile Leu Ile Asn Arg Glu Pro Leu Pro His 
                165                 170                 175     


Leu His Phe Asp Val Glu Leu Leu Gly Asp Cys Asp Val Ile Ile Asn 
            180                 185                 190         


Glu Leu Cys His Arg Leu Gly Gly Glu Tyr Ala Lys Leu Cys Cys Asn 
        195                 200                 205             


Pro Val Lys Leu Ser Glu Ile Thr Glu Lys Pro Pro Arg Thr Gln Lys 
    210                 215                 220                 


Glu Leu Ala Tyr Leu Ser Glu Leu Pro Pro Thr Pro Leu His Val Ser 
225                 230                 235                 240 


Glu Asp Ser Ser Ser Pro Glu Arg Thr Ser Pro Pro Asp Ser Ser Val 
                245                 250                 255     


Ile Val Thr Leu Leu Asp Gln Ala Ala Lys Ser Asn Asp Asp Leu Asp 
            260                 265                 270         


Val Ser Glu Ser Lys Gly Cys Met Glu Glu Lys Pro Gln Glu Val Gln 
        275                 280                 285             


Thr Ser Arg Asn Val Glu Ser Ile Ala Glu Gln Met Glu Asn Pro Asp 
    290                 295                 300                 


Leu Lys Asn Val Gly Ser Ser Thr Gly Glu Lys Asn Glu Arg Thr Ser 
305                 310                 315                 320 


Val Ala Gly Thr Val Arg Lys Cys Trp Pro Asn Arg Val Ala Lys Glu 
                325                 330                 335     


Gln Ile Ser Arg Arg Leu Asp Gly Asn Gln Tyr Leu Phe Leu Pro Pro 
            340                 345                 350         


Asn Arg Tyr Ile Phe His Gly Ala Glu Val Tyr Ser Asp Ser Glu Asp 
        355                 360                 365             


Asp Val Leu Ser Ser Ser Ser Cys Gly Ser Asn Ser Asp Ser Gly Thr 
    370                 375                 380                 


Cys Gln Ser Pro Ser Leu Glu Glu Pro Met Glu Asp Glu Ser Glu Ile 
385                 390                 395                 400 


Glu Glu Phe Tyr Asn Gly Leu Glu Asp Glu Pro Asp Val Pro Glu Arg 
                405                 410                 415     


Ala Gly Gly Ala Gly Phe Gly Thr Asp Gly Asp Asp Gln Glu Ala Ile 
            420                 425                 430         


Asn Glu Ala Ile Ser Val Lys Gln Glu Val Thr Asp Met Asn Tyr Pro 
        435                 440                 445             


Ser Asn Lys Ser 
    450         


<210>  115
<211>  704
<212>  PRT
<213>  Homo sapiens

<400>  115

Met Asp His Ile Thr Val Pro Lys Val Glu Asn Val Lys Leu Val Asp 
1               5                   10                  15      


Arg Tyr Val Ser Lys Lys Pro Ala Asn Gly Ile Leu Tyr Leu Thr Ala 
            20                  25                  30          


Thr His Leu Ile Tyr Val Glu Ala Ser Gly Ala Ala Arg Lys Glu Thr 
        35                  40                  45              


Trp Ile Ala Leu His His Ile Ala Thr Val Glu Lys Leu Pro Ile Thr 
    50                  55                  60                  


Ser Leu Gly Cys Pro Leu Thr Leu Arg Cys Lys Asn Phe Arg Val Ala 
65                  70                  75                  80  


His Phe Val Leu Asp Ser Asp Leu Val Cys His Glu Val Tyr Ile Ser 
                85                  90                  95      


Leu Leu Lys Leu Ser Gln Pro Ala Leu Pro Glu Asp Leu Tyr Ala Phe 
            100                 105                 110         


Ser Tyr Asn Pro Lys Ser Ser Lys Glu Met Arg Glu Ser Gly Trp Lys 
        115                 120                 125             


Leu Ile Asp Pro Ile Ser Asp Phe Gly Arg Met Gly Ile Pro Asn Arg 
    130                 135                 140                 


Asn Trp Thr Ile Thr Asp Ala Asn Arg Asn Tyr Glu Ile Cys Ser Thr 
145                 150                 155                 160 


Tyr Pro Pro Glu Ile Val Val Pro Lys Ser Val Thr Leu Gly Thr Val 
                165                 170                 175     


Val Gly Ser Ser Lys Phe Arg Ser Lys Glu Arg Val Pro Val Leu Ser 
            180                 185                 190         


Tyr Leu Tyr Lys Glu Asn Asn Ala Ala Ile Cys Arg Cys Ser Gln Pro 
        195                 200                 205             


Leu Ser Gly Phe Tyr Thr Arg Cys Val Asp Asp Glu Leu Leu Leu Glu 
    210                 215                 220                 


Ala Ile Ser Gln Thr Asn Pro Gly Ser Gln Phe Met Tyr Val Val Asp 
225                 230                 235                 240 


Thr Arg Pro Lys Leu Asn Ala Met Ala Asn Arg Ala Ala Gly Lys Gly 
                245                 250                 255     


Tyr Glu Asn Glu Asp Asn Tyr Ala Asn Ile Arg Phe Arg Phe Met Gly 
            260                 265                 270         


Ile Glu Asn Ile His Val Met Arg Ser Ser Leu Gln Lys Leu Leu Glu 
        275                 280                 285             


Val Cys Glu Leu Lys Thr Pro Thr Met Ser Glu Phe Leu Ser Gly Leu 
    290                 295                 300                 


Glu Ser Ser Gly Trp Leu Arg His Ile Lys Ala Ile Met Asp Ala Gly 
305                 310                 315                 320 


Ile Phe Ile Thr Lys Ala Val Lys Val Glu Lys Ala Ser Val Leu Val 
                325                 330                 335     


His Cys Ser Asp Gly Trp Asp Arg Thr Ala Gln Val Cys Ser Val Ala 
            340                 345                 350         


Ser Ile Leu Leu Asp Pro Phe Tyr Arg Thr Phe Lys Gly Leu Met Ile 
        355                 360                 365             


Leu Ile Glu Lys Glu Trp Ile Ser Met Gly His Lys Phe Ser Gln Arg 
    370                 375                 380                 


Cys Gly His Leu Asp Gly Asp Ser Lys Glu Val Ser Pro Ile Phe Thr 
385                 390                 395                 400 


Gln Phe Leu Asp Cys Ile Trp Gln Leu Met Glu Gln Phe Pro Cys Ala 
                405                 410                 415     


Phe Glu Phe Asn Glu Asn Phe Leu Leu Glu Ile His Asp His Val Phe 
            420                 425                 430         


Ser Cys Gln Phe Gly Asn Phe Leu Gly Asn Cys Gln Lys Asp Arg Glu 
        435                 440                 445             


Asp Leu Arg Val Tyr Glu Lys Thr His Ser Val Trp Pro Phe Leu Val 
    450                 455                 460                 


Gln Arg Lys Pro Asp Phe Arg Asn Pro Leu Tyr Lys Gly Phe Thr Met 
465                 470                 475                 480 


Tyr Gly Val Leu Asn Pro Ser Thr Val Pro Tyr Asn Ile Gln Phe Trp 
                485                 490                 495     


Cys Gly Met Tyr Asn Arg Phe Asp Lys Gly Leu Gln Pro Lys Gln Ser 
            500                 505                 510         


Met Leu Glu Ser Leu Leu Glu Ile Lys Lys Gln Arg Ala Met Leu Glu 
        515                 520                 525             


Thr Asp Val His Glu Leu Glu Lys Lys Leu Lys Val Arg Asp Glu Pro 
    530                 535                 540                 


Pro Glu Glu Ile Cys Thr Cys Ser Gln Leu Gly Asn Ile Leu Ser Gln 
545                 550                 555                 560 


His Leu Gly Ser Pro Leu Thr Asn Pro Leu Gly Phe Met Gly Ile Asn 
                565                 570                 575     


Gly Asp Leu Asn Thr Leu Met Glu Asn Gly Thr Leu Ser Arg Glu Gly 
            580                 585                 590         


Gly Leu Arg Ala Gln Met Asp Gln Val Lys Ser Gln Gly Ala Asp Leu 
        595                 600                 605             


His His Asn Cys Cys Glu Ile Val Gly Ser Leu Arg Ala Ile Asn Ile 
    610                 615                 620                 


Ser Gly Asp Val Gly Ile Ser Glu Ala Met Gly Ile Ser Gly Asp Met 
625                 630                 635                 640 


Cys Thr Phe Glu Ala Thr Gly Phe Ser Lys Asp Leu Gly Ile Cys Gly 
                645                 650                 655     


Ala Met Asp Ile Ser Glu Ala Thr Gly Ile Ser Gly Asn Leu Gly Ile 
            660                 665                 670         


Ser Glu Ala Arg Gly Phe Ser Gly Asp Met Gly Ile Leu Gly Asp Thr 
        675                 680                 685             


Gly Ile Ser Lys Ala Ser Thr Lys Glu Ala Asp Tyr Ser Lys His Gln 
    690                 695                 700                 


<210>  116
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Pro Ser Leu Trp Asp Arg Phe Ser Ser Ser Ser Thr Ser Ser Ser 
1               5                   10                  15      


Pro Ser Ser Leu Pro Arg Thr Pro Thr Pro Asp Arg Pro Pro Arg Ser 
            20                  25                  30          


Ala Trp Gly Ser Ala Thr Arg Glu Glu Gly Phe Asp Arg Ser Thr Ser 
        35                  40                  45              


Leu Glu Ser Ser Asp Cys Glu Ser Leu Asp Ser Ser Asn Ser Gly Phe 
    50                  55                  60                  


Gly Pro Glu Glu Asp Thr Ala Tyr Leu Asp Gly Val Ser Leu Pro Asp 
65                  70                  75                  80  


Phe Glu Leu Leu Ser Asp Pro Glu Asp Glu His Leu Cys Ala Asn Leu 
                85                  90                  95      


Met Gln Leu Leu Gln Glu Ser Leu Ala Gln Ala Arg Leu Gly Ser Arg 
            100                 105                 110         


Arg Pro Ala Arg Leu Leu Met Pro Ser Gln Leu Val Ser Gln Val Gly 
        115                 120                 125             


Lys Glu Leu Leu Arg Leu Ala Tyr Ser Glu Pro Cys Gly Leu Arg Gly 
    130                 135                 140                 


Ala Leu Leu Asp Val Cys Val Glu Gln Gly Lys Ser Cys His Ser Val 
145                 150                 155                 160 


Gly Gln Leu Ala Leu Asp Pro Ser Leu Val Pro Thr Phe Gln Leu Thr 
                165                 170                 175     


Leu Val Leu Arg Leu Asp Ser Arg Leu Trp Pro Lys Ile Gln Gly Leu 
            180                 185                 190         


Phe Ser Ser Ala Asn Ser Pro Phe Leu Pro Gly Phe Ser Gln Ser Leu 
        195                 200                 205             


Thr Leu Ser Thr Gly Phe Arg Val Ile Lys Lys Lys Leu Tyr Ser Ser 
    210                 215                 220                 


Glu Gln Leu Leu Ile Glu Glu Cys 
225                 230         


<210>  117
<211>  642
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Glu Glu Glu Arg Lys Thr Ala Glu Leu Gln Lys Asn Arg Ile Gln 
1               5                   10                  15      


Asp Ser Val Val Phe Glu Asp Val Ala Val Asp Phe Thr Gln Glu Glu 
            20                  25                  30          


Trp Ala Leu Leu Asp Leu Ala Gln Arg Asn Leu Tyr Arg Asp Val Met 
        35                  40                  45              


Leu Glu Asn Phe Gln Asn Leu Ala Ser Leu Gly Tyr Pro Leu His Thr 
    50                  55                  60                  


Pro His Leu Ile Ser Gln Trp Glu Gln Glu Glu Asp Leu Gln Thr Val 
65                  70                  75                  80  


Lys Arg Glu Leu Ile Gln Gly Ile Phe Met Gly Glu His Arg Glu Gly 
                85                  90                  95      


Phe Glu Thr Gln Leu Lys Thr Asn Glu Ser Val Ala Ser Gln Asp Ile 
            100                 105                 110         


Cys Gly Glu Lys Ile Ser Asn Glu Gln Lys Ile Val Arg Phe Lys Arg 
        115                 120                 125             


Asn Asp Ser Trp Phe Ser Ser Leu His Glu Asn Gln Glu Ser Cys Gly 
    130                 135                 140                 


Ile Asp Tyr Gln Asn Lys Ser His Glu Arg His Leu Arg Asn His Met 
145                 150                 155                 160 


Val Glu Asn Ile Tyr Glu Cys Tyr Glu Glu Asn Gln Asp Gly Gln Thr 
                165                 170                 175     


Phe Ser Gln Val Pro Asn Leu Asp Ser Leu Lys Arg Asn Thr Glu Val 
            180                 185                 190         


Lys Ser Cys Glu Cys His Glu Cys Gly Lys Ala Phe Val Asp His Ser 
        195                 200                 205             


Ser Leu Lys Ser His Ile Arg Ser His Thr Gly Ser Lys Pro Tyr Gln 
    210                 215                 220                 


Cys Lys Glu Cys Gly Lys Ala Phe His Phe Leu Ala Cys Phe Lys Lys 
225                 230                 235                 240 


His Met Lys Thr Pro Thr Glu Glu Lys Pro Tyr Glu Cys Lys Glu Cys 
                245                 250                 255     


Thr Lys Ala Phe Ser Cys Ser Ser Phe Phe Arg Ala His Met Lys Ile 
            260                 265                 270         


His Ile Gly Lys Thr Asn Tyr Glu Cys Lys Glu Cys Gly Lys Gly Phe 
        275                 280                 285             


Ser Cys Ser Ser Ser Leu Thr Glu His Lys Arg Ile His Ser Gly Asp 
    290                 295                 300                 


Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Ser Cys Ser Ser 
305                 310                 315                 320 


Ser Leu Ser Lys His Lys Arg Ile His Ser Gly Asp Lys Pro Tyr Glu 
                325                 330                 335     


Cys Lys Glu Cys Gly Lys Ala Phe Ser Ser Ser Ser His Leu Ile Ile 
            340                 345                 350         


His Ile Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys 
        355                 360                 365             


Gly Lys Ala Phe Ser Glu Ser Ser Lys Leu Thr Val His Gly Arg Thr 
    370                 375                 380                 


His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys Ala Tyr 
385                 390                 395                 400 


Asn Cys Pro Ser Ser Leu Ser Ile His Met Arg Lys His Thr Gly Glu 
                405                 410                 415     


Lys Pro Tyr Glu Cys Leu Glu Cys Gly Lys Ala Phe Tyr Leu Pro Thr 
            420                 425                 430         


Ser Leu Asn Thr His Val Lys Asn Gln Ser Arg Glu Lys Pro Tyr Glu 
        435                 440                 445             


Cys Lys Glu Cys Gly Lys Ala Phe Ser Cys Pro Ser Ser Phe Arg Ala 
    450                 455                 460                 


His Val Arg Asp His Thr Gly Lys Ile Gln Tyr Glu Cys Lys Glu Cys 
465                 470                 475                 480 


Gly Lys Thr Phe Ser Arg Ser Ser Ser Leu Thr Glu His Leu Arg Thr 
                485                 490                 495     


His Ser Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe 
            500                 505                 510         


Ile Ser Ser Ser His Leu Thr Val His Ile Arg Thr His Thr Gly Glu 
        515                 520                 525             


Lys Pro Tyr Glu Cys Lys Lys Cys Gly Lys Ala Phe Ile Tyr Pro Ser 
    530                 535                 540                 


Ala Leu Arg Ile His Met Arg Thr His Thr Gly Glu Lys Pro Tyr Glu 
545                 550                 555                 560 


Cys Lys Glu Cys Gly Lys Ala Phe Arg His Ser Ser Tyr Leu Thr Val 
                565                 570                 575     


His Ala Arg Met His Thr Gly Glu Lys Pro Phe Glu Cys Leu Glu Cys 
            580                 585                 590         


Gly Lys Ala Phe Ser Cys Pro Ser Ser Phe Arg Arg His Val Arg Ser 
        595                 600                 605             


His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe 
    610                 615                 620                 


Val Cys Pro Ala Tyr Phe Arg Arg His Val Lys Thr His Thr Arg Glu 
625                 630                 635                 640 


Asn Ile 
        


<210>  118
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Gln Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Leu Ala Trp Ala Val Ala 
            340                 345                 350         


Met Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile Ala 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp Thr 
385                 390                 395                 400 


Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210>  119
<211>  199
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  119

Xaa Asp Ile Pro Gly Ala Arg Ala Leu Asp Asn Gly Leu Ala Arg Thr 
1               5                   10                  15      


Pro Thr Met Gly Trp Leu His Trp Glu Arg Phe Met Cys Asn Leu Asp 
            20                  25                  30          


Cys Gln Glu Glu Pro Asp Ser Cys Ile Ser Glu Lys Leu Phe Met Glu 
        35                  40                  45              


Met Ala Glu Leu Met Val Ser Glu Gly Trp Lys Asp Ala Gly Tyr Glu 
    50                  55                  60                  


Tyr Leu Cys Ile Asp Asp Cys Trp Met Ala Pro Gln Arg Asp Ser Glu 
65                  70                  75                  80  


Gly Arg Leu Gln Ala Asp Pro Gln Arg Phe Pro His Gly Ile Arg Gln 
                85                  90                  95      


Leu Ala Asn Tyr Val His Ser Lys Gly Leu Lys Leu Gly Ile Tyr Ala 
            100                 105                 110         


Asp Val Gly Asn Lys Thr Cys Ala Gly Phe Pro Gly Ser Phe Gly Tyr 
        115                 120                 125             


Tyr Asp Ile Asp Ala Gln Thr Phe Ala Asp Trp Gly Val Asp Leu Leu 
    130                 135                 140                 


Lys Phe Asp Gly Cys Tyr Cys Asp Ser Leu Glu Asn Leu Ala Asp Gly 
145                 150                 155                 160 


Glu Ser Arg Leu Ser Ile Gly His Arg Glu Arg Ser Ile Phe Ile Pro 
                165                 170                 175     


Ala Phe Pro Gln Tyr Thr His His Leu Cys Thr Thr Ser Ser Glu Gln 
            180                 185                 190         


Ser Gln Gln Ser Gly Arg Leu 
        195                 


<210>  120
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Ser Ser Thr Leu Phe Gly Ser Ile Cys 
    210                 215                 220         


<210>  121
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  121

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Ala Gln Leu Tyr Arg Asn Pro Thr Val Leu 
            180                 185                 190         


Gln Ser Leu Ala Lys Phe Cys 
        195                 


<210>  122
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Trp Ser Phe Ala Leu Val Ala Gln Ala Gly Val Gln Cys His Asp 
65                  70                  75                  80  


Leu Gly Ser Pro Gln Pro Pro Pro Pro Arg Phe Lys Gln Phe Ser Cys 
                85                  90                  95      


Leu Ile Leu Ala Ser Ser Trp Asn Tyr Ser Glu Lys Leu Phe Met Glu 
            100                 105                 110         


Met Ala Glu Leu Met Val Ser Glu Gly Trp Lys Asp Ala Gly Tyr Glu 
        115                 120                 125             


Tyr Leu Cys Ile Asp Asp Cys Trp Met Ala Pro Gln Arg Asp Ser Glu 
    130                 135                 140                 


Gly Arg Leu Gln Ala Asp Pro Gln Arg Phe Pro His Gly Ile Arg Gln 
145                 150                 155                 160 


Leu Ala Asn Tyr Val His Ser Lys Gly Leu Lys Leu Gly Ile Tyr Ala 
                165                 170                 175     


Asp Val Gly Asn Lys Thr Cys Ala Gly Phe Pro Gly Ser Phe Gly Tyr 
            180                 185                 190         


Tyr Asp Ile Asp Ala Gln Thr Phe Ala Asp Trp Gly Val Asp Leu Leu 
        195                 200                 205             


Lys Phe Asp Gly Cys Tyr Cys Asp Ser Leu Glu Asn Leu Ala Asp Gly 
    210                 215                 220                 


Tyr Lys His Met Ser Leu Ala Leu Asn Arg Thr Gly Arg Ser Ile Val 
225                 230                 235                 240 


Tyr Ser Cys Glu Trp Pro Leu Tyr Met Trp Pro Phe Gln Lys Pro Asn 
                245                 250                 255     


Tyr Thr Glu Ile Arg Gln Tyr Cys Asn His Trp Arg Asn Phe Ala Asp 
            260                 265                 270         


Ile Asp Asp Ser Trp Lys Ser Ile Lys Ser Ile Leu Asp Trp Thr Ser 
        275                 280                 285             


Phe Asn Gln Glu Arg Ile Val Asp Val Ala Gly Pro Gly Gly Trp Asn 
    290                 295                 300                 


Asp Pro Asp Met Leu Val Ile Gly Asn Phe Gly Leu Ser Trp Asn Gln 
305                 310                 315                 320 


Gln Val Thr Gln Met Ala Leu Trp Ala Ile Met Ala Ala Pro Leu Phe 
                325                 330                 335     


Met Ser Asn Asp Leu Arg His Ile Ser Pro Gln Ala Lys Ala Leu Leu 
            340                 345                 350         


Gln Asp Lys Asp Val Ile Ala Ile Asn Gln Asp Pro Leu Gly Lys Gln 
        355                 360                 365             


Gly Tyr Gln Leu Arg Gln Gly Asp Asn Phe Glu Val Trp Glu Arg Pro 
    370                 375                 380                 


Leu Ser Gly Leu Ala Trp Ala Val Ala Met Ile Asn Arg Gln Glu Ile 
385                 390                 395                 400 


Gly Gly Pro Arg Ser Tyr Thr Ile Ala Val Ala Ser Leu Gly Lys Gly 
                405                 410                 415     


Val Ala Cys Asn Pro Ala Cys Phe Ile Thr Gln Leu Leu Pro Val Lys 
            420                 425                 430         


Arg Lys Leu Gly Phe Tyr Glu Trp Thr Ser Arg Leu Arg Ser His Ile 
        435                 440                 445             


Asn Pro Thr Gly Thr Val Leu Leu Gln Leu Glu Asn Thr Met Gln Met 
    450                 455                 460                 


Ser Leu Lys Asp Leu Leu 
465                 470 


<210>  123
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  123

Asp Ile Pro Gly Ala Arg Ala Leu Asp Asn Gly Leu Ala Arg Thr Pro 
1               5                   10                  15      


Thr Met Gly Trp Leu His Trp Glu Arg Phe Met Cys Asn Leu Asp Cys 
            20                  25                  30          


Gln Glu Glu Pro Asp Ser Cys Ile Ser Glu Lys Leu Phe Met Glu Met 
        35                  40                  45              


Ala Glu Leu Met Val Ser Glu Gly Trp Lys Asp Ala Gly Tyr Glu Tyr 
    50                  55                  60                  


Leu Cys Ile Asp Asp Cys Trp Met Ala Pro Gln Arg Asp Ser Glu Gly 
65                  70                  75                  80  


Arg Leu Gln Ala Asp Pro Gln Arg Phe Pro His Gly Ile Arg Gln Leu 
                85                  90                  95      


Ala Asn Tyr Val His Ser Lys Gly Leu Lys Leu Gly Ile Tyr Ala Asp 
            100                 105                 110         


Val Gly Asn Lys Thr Cys Ala Gly Phe Pro Gly Ser Phe Gly Tyr Tyr 
        115                 120                 125             


Asp Ile Asp Ala Gln Thr Phe Ala Asp Trp Gly Val Asp Leu Leu Lys 
    130                 135                 140                 


Phe Asp Gly Cys Tyr Cys Asp Ser Leu Glu Asn Leu Ala Asp Gly Glu 
145                 150                 155                 160 


Ser Arg Leu Ser Ile Gly His Arg Glu Arg Ser Ile Phe Ile Pro Ala 
                165                 170                 175     


Phe Pro Gln Tyr Thr His His Leu Cys Thr Thr Ser Ser Glu Gln Ser 
            180                 185                 190         


Gln Gln Ser Gly Arg Leu 
        195             


<210>  124
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Gln Val Asn Lys 
                325                 330                 335     


Ser Ile Tyr Phe Lys Met Ala Leu Tyr Thr Gln Tyr Gln Leu Cys Leu 
            340                 345                 350         


Gly Pro Lys Ser Ile Phe Phe Pro Cys Ser 
        355                 360         


<210>  125
<211>  363
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Gly Asp Asn Phe Glu 
            260                 265                 270         


Val Trp Glu Arg Pro Leu Ser Gly Leu Ala Trp Ala Val Ala Met Ile 
        275                 280                 285             


Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile Ala Val Ala 
    290                 295                 300                 


Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile Thr Gln 
305                 310                 315                 320 


Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp Thr Ser Arg 
                325                 330                 335     


Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln Leu Glu 
            340                 345                 350         


Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
        355                 360             


<210>  126
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Tyr Lys His Met Ser 
                165                 170                 175     


Leu Ala Leu Asn Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp 
            180                 185                 190         


Pro Leu Tyr Met Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg 
        195                 200                 205             


Gln Tyr Cys Asn His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp 
    210                 215                 220                 


Lys Ser Ile Lys Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg 
225                 230                 235                 240 


Ile Val Asp Val Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu 
                245                 250                 255     


Val Ile Gly Asn Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met 
            260                 265                 270         


Ala Leu Trp Ala Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu 
        275                 280                 285             


Arg His Ile Ser Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val 
    290                 295                 300                 


Ile Ala Ile Asn Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg 
305                 310                 315                 320 


Gln Gly Asp Asn Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Leu Ala 
                325                 330                 335     


Trp Ala Val Ala Met Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser 
            340                 345                 350         


Tyr Thr Ile Ala Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro 
        355                 360                 365             


Ala Cys Phe Ile Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe 
    370                 375                 380                 


Tyr Glu Trp Thr Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr 
385                 390                 395                 400 


Val Leu Leu Gln Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu 
                405                 410                 415     


Leu 
    


<210>  127
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  127

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Val Lys Thr 
            260                 265                 270 


<210>  128
<211>  810
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Ile Pro Val Thr Glu Leu Arg Tyr Phe Ala Asp Thr Gln Pro Ala 
1               5                   10                  15      


Tyr Arg Ile Leu Lys Pro Trp Trp Asp Val Phe Thr Asp Tyr Ile Ser 
            20                  25                  30          


Ile Val Met Leu Met Ile Ala Val Phe Gly Gly Thr Leu Gln Val Thr 
        35                  40                  45              


Gln Asp Lys Met Ile Cys Leu Pro Cys Lys Trp Val Thr Lys Asp Ser 
    50                  55                  60                  


Cys Asn Asp Ser Phe Arg Gly Trp Ala Ala Pro Gly Pro Glu Pro Thr 
65                  70                  75                  80  


Tyr Pro Asn Ser Thr Ile Leu Pro Thr Pro Asp Thr Gly Pro Thr Gly 
                85                  90                  95      


Ile Lys Tyr Asp Leu Asp Arg His Gln Tyr Asn Tyr Val Asp Ala Val 
            100                 105                 110         


Cys Tyr Glu Asn Arg Leu His Trp Phe Ala Lys Tyr Phe Pro Tyr Leu 
        115                 120                 125             


Val Leu Leu His Thr Leu Ile Phe Leu Ala Cys Ser Asn Phe Trp Phe 
    130                 135                 140                 


Lys Phe Pro Arg Thr Ser Ser Lys Leu Glu His Phe Val Ser Ile Leu 
145                 150                 155                 160 


Leu Lys Cys Phe Asp Ser Pro Trp Thr Thr Arg Ala Leu Ser Glu Thr 
                165                 170                 175     


Val Val Glu Glu Ser Asp Pro Lys Pro Ala Phe Ser Lys Met Asn Gly 
            180                 185                 190         


Ser Met Asp Lys Lys Ser Ser Thr Val Ser Glu Asp Val Glu Ala Thr 
        195                 200                 205             


Val Pro Met Leu Gln Arg Thr Lys Ser Arg Ile Glu Gln Gly Ile Val 
    210                 215                 220                 


Asp Arg Ser Glu Thr Gly Val Leu Asp Lys Lys Glu Gly Glu Gln Ala 
225                 230                 235                 240 


Lys Ala Leu Phe Glu Lys Val Lys Lys Phe Arg Thr His Val Glu Glu 
                245                 250                 255     


Gly Asp Ile Val Tyr Arg Leu Tyr Met Arg Gln Thr Ile Ile Lys Val 
            260                 265                 270         


Ile Lys Phe Ile Leu Ile Ile Cys Tyr Thr Val Tyr Tyr Val His Asn 
        275                 280                 285             


Ile Lys Phe Asp Val Asp Cys Thr Val Asp Ile Glu Ser Leu Thr Gly 
    290                 295                 300                 


Tyr Arg Thr Tyr Arg Cys Ala His Pro Leu Ala Thr Leu Phe Lys Ile 
305                 310                 315                 320 


Leu Ala Ser Phe Tyr Ile Ser Leu Val Ile Phe Tyr Gly Leu Ile Cys 
                325                 330                 335     


Met Tyr Thr Leu Trp Trp Met Leu Arg Arg Ser Leu Lys Lys Tyr Ser 
            340                 345                 350         


Phe Glu Ser Ile Arg Glu Glu Ser Ser Tyr Ser Asp Ile Pro Asp Val 
        355                 360                 365             


Lys Asn Asp Phe Ala Phe Met Leu His Leu Ile Asp Gln Tyr Asp Pro 
    370                 375                 380                 


Leu Tyr Ser Lys Arg Phe Ala Val Phe Leu Ser Glu Val Ser Glu Asn 
385                 390                 395                 400 


Lys Leu Arg Gln Leu Asn Leu Asn Asn Glu Trp Thr Leu Asp Lys Leu 
                405                 410                 415     


Arg Gln Arg Leu Thr Lys Asn Ala Gln Asp Lys Leu Glu Leu His Leu 
            420                 425                 430         


Phe Met Leu Ser Gly Ile Pro Asp Thr Val Phe Asp Leu Val Glu Leu 
        435                 440                 445             


Glu Val Leu Lys Leu Glu Leu Ile Pro Asp Val Thr Ile Pro Pro Ser 
    450                 455                 460                 


Ile Ala Gln Leu Thr Gly Leu Lys Glu Leu Trp Leu Tyr His Thr Ala 
465                 470                 475                 480 


Ala Lys Ile Glu Ala Pro Ala Leu Ala Phe Leu Arg Glu Asn Leu Arg 
                485                 490                 495     


Ala Leu His Ile Lys Phe Thr Asp Ile Lys Glu Ile Pro Leu Trp Ile 
            500                 505                 510         


Tyr Ser Leu Lys Thr Leu Glu Glu Leu His Leu Thr Gly Asn Leu Ser 
        515                 520                 525             


Ala Glu Asn Asn Arg Tyr Ile Val Ile Asp Gly Leu Arg Glu Leu Lys 
    530                 535                 540                 


Arg Leu Lys Val Leu Arg Leu Lys Ser Asn Leu Ser Lys Leu Pro Gln 
545                 550                 555                 560 


Val Val Thr Asp Val Gly Val His Leu Gln Lys Leu Ser Ile Asn Asn 
                565                 570                 575     


Glu Gly Thr Lys Leu Ile Val Leu Asn Ser Leu Lys Lys Met Ala Asn 
            580                 585                 590         


Leu Thr Glu Leu Glu Leu Ile Arg Cys Asp Leu Glu Arg Ile Pro His 
        595                 600                 605             


Ser Ile Phe Ser Leu His Asn Leu Gln Glu Ile Asp Leu Lys Asp Asn 
    610                 615                 620                 


Asn Leu Lys Thr Ile Glu Glu Ile Ile Ser Phe Gln His Leu His Arg 
625                 630                 635                 640 


Leu Thr Cys Leu Lys Leu Trp Tyr Asn His Ile Ala Tyr Ile Pro Ile 
                645                 650                 655     


Gln Ile Gly Asn Leu Thr Asn Leu Glu Arg Leu Tyr Leu Asn Arg Asn 
            660                 665                 670         


Lys Ile Glu Lys Ile Pro Thr Gln Leu Phe Tyr Cys Arg Lys Leu Arg 
        675                 680                 685             


Tyr Leu Asp Leu Ser His Asn Asn Leu Thr Phe Leu Pro Ala Asp Ile 
    690                 695                 700                 


Gly Leu Leu Gln Asn Leu Gln Asn Leu Ala Ile Thr Ala Asn Arg Ile 
705                 710                 715                 720 


Glu Thr Leu Pro Pro Glu Leu Phe Gln Cys Arg Lys Leu Arg Ala Leu 
                725                 730                 735     


His Leu Gly Asn Asn Val Leu Gln Ser Leu Pro Ser Arg Val Gly Glu 
            740                 745                 750         


Leu Thr Asn Leu Thr Gln Ile Glu Leu Arg Gly Asn Arg Leu Glu Cys 
        755                 760                 765             


Leu Pro Val Glu Leu Gly Glu Cys Pro Leu Leu Lys Arg Ser Gly Leu 
    770                 775                 780                 


Val Val Glu Glu Asp Leu Phe Asn Thr Leu Pro Pro Glu Val Lys Glu 
785                 790                 795                 800 


Arg Leu Trp Arg Ala Asp Lys Glu Gln Ala 
                805                 810 


<210>  129
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Gly Ser Leu Tyr Ser Glu Tyr Leu Asn Pro Asn Lys Val Gln Glu 
1               5                   10                  15      


His Tyr Asn Tyr Thr Lys Glu Thr Leu Glu Thr Gln Glu Thr Thr Ser 
            20                  25                  30          


Arg Gln Val Ala Ser Ala Phe Ile Val Ile Leu Cys Cys Ala Ile Val 
        35                  40                  45              


Val Glu Asn Leu Leu Val Leu Ile Ala Val Ala Arg Asn Ser Lys Phe 
    50                  55                  60                  


His Ser Ala Met Tyr Leu Phe Leu Gly Asn Leu Ala Ala Ser Asp Leu 
65                  70                  75                  80  


Leu Ala Gly Val Ala Phe Val Ala Asn Thr Leu Leu Ser Gly Ser Val 
                85                  90                  95      


Thr Leu Arg Leu Thr Pro Val Gln Trp Phe Ala Arg Glu Gly Ser Ala 
            100                 105                 110         


Phe Ile Thr Leu Ser Ala Ser Val Phe Ser Leu Leu Ala Ile Ala Ile 
        115                 120                 125             


Glu Arg His Val Ala Ile Ala Lys Val Lys Leu Tyr Gly Ser Asp Lys 
    130                 135                 140                 


Ser Cys Arg Met Leu Leu Leu Ile Gly Ala Ser Trp Leu Ile Ser Leu 
145                 150                 155                 160 


Val Leu Gly Gly Leu Pro Ile Leu Gly Trp Asn Cys Leu Gly His Leu 
                165                 170                 175     


Glu Ala Cys Ser Thr Val Leu Pro Leu Tyr Ala Lys His Tyr Val Leu 
            180                 185                 190         


Cys Val Val Thr Ile Phe Ser Ile Ile Leu Leu Ala Ile Val Ala Leu 
        195                 200                 205             


Tyr Val Arg Ile Tyr Cys Val Val Arg Ser Ser His Ala Asp Met Ala 
    210                 215                 220                 


Ala Pro Gln Thr Leu Ala Leu Leu Lys Thr Val Thr Ile Val Leu Gly 
225                 230                 235                 240 


Val Phe Ile Val Cys Trp Leu Pro Ala Phe Ser Ile Leu Leu Leu Asp 
                245                 250                 255     


Tyr Ala Cys Pro Val His Ser Cys Pro Ile Leu Tyr Lys Ala His Tyr 
            260                 265                 270         


Phe Phe Ala Val Ser Thr Leu Asn Ser Leu Leu Asn Pro Val Ile Tyr 
        275                 280                 285             


Thr Trp Arg Ser Arg Asp Leu Arg Arg Glu Val Leu Arg Pro Leu Gln 
    290                 295                 300                 


Cys Trp Arg Pro Gly Val Gly Val Gln Gly Arg Arg Arg Gly Gly Thr 
305                 310                 315                 320 


Pro Gly His His Leu Leu Pro Leu Arg Ser Ser Ser Ser Leu Glu Arg 
                325                 330                 335     


Gly Met His Met Pro Thr Ser Pro Thr Phe Leu Glu Gly Asn Thr Val 
            340                 345                 350         


Val 
    


<210>  130
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu 
1               5                   10                  15      


Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser 
            20                  25                  30          


Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys 
        35                  40                  45              


Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu 
    50                  55                  60                  


Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu 
65                  70                  75                  80  


Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys 
                85                  90                  95      


Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr 
            100                 105                 110         


Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly 
        115                 120                 125             


Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala 
    130                 135                 140                 


Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu 
145                 150                 155                 160 


Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg 
                165                 170                 175     


Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu 
            180                 185                 190         


Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln 
        195                 200                 205             


Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro 
    210                 215                 220                 


Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp 
225                 230                 235                 240 


Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp 
                245                 250                 255     


Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala 
            260                 265                 270         


Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu 
        275                 280                 285             


Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr 
    290                 295                 300                 


Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro 
305                 310                 315                 320 


Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro 
                325                 330                 335     


Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro 
            340                 345                 350         


Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser 
        355                 360                 365             


Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys 
    370                 375                 380                 


Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu 
385                 390                 395                 400 


Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr 
                405                 410                 415     


Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu 
            420                 425                 430         


Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr 
        435                 440                 445             


Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly 
    450                 455                 460                 


Glu Val Thr Arg Lys Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu 
465                 470                 475                 480 


Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala 
                485                 490                 495     


Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr 
            500                 505                 510         


Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln 
        515                 520                 525             


Ala Thr Pro Pro 
    530         


<210>  131
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  131

Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu 
1               5                   10                  15      


Leu Gly Ala Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu 
            20                  25                  30          


Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe 
        35                  40                  45              


Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln 
    50                  55                  60                  


Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu 
65                  70                  75                  80  


Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr 
                85                  90                  95      


Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala 
            100                 105                 110         


His Pro Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu 
        115                 120                 125             


Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly 
    130                 135                 140                 


Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile 
145                 150                 155                 160 


His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu 
                165                 170                 175     


Asp Glu Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln 
            180                 185                 190         


Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys 
        195                 200                 205             


Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr 
    210                 215                 220                 


Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr 
225                 230                 235                 240 


Gln Gly Glu Val Thr Arg Lys Val Thr Val Asn Val Leu Ser Pro Arg 
                245                 250                 255     


Tyr Glu Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly 
            260                 265                 270         


Thr Ala Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys 
        275                 280                 285             


Lys Tyr Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn 
    290                 295                 300                 


Thr Gln Ala Thr Pro Pro 
305                 310 


<210>  132
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu 
1               5                   10                  15      


Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser 
            20                  25                  30          


Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys 
        35                  40                  45              


Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu 
    50                  55                  60                  


Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu 
65                  70                  75                  80  


Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys 
                85                  90                  95      


Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr 
            100                 105                 110         


Pro Glu Arg Val Glu Gly Gly Ala Pro Arg Ala Asn Leu Thr Val Val 
        115                 120                 125             


Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu Pro Ala Val Gly Glu 
    130                 135                 140                 


Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg Arg Asp His His Gly 
145                 150                 155                 160 


Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu 
                165                 170                 175     


Glu Leu Phe Glu 
            180 


<210>  133
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  133

Met Ala Ala Gly Cys Cys Gly Val Lys Lys Gln Lys Leu Ser Ser Ser 
1               5                   10                  15      


Pro Pro Ser Gly Ser Gly Gly Gly Gly Gly Ala Ser Ser Ser Ser His 
            20                  25                  30          


Cys Ser Gly Glu Ser Gln Cys Arg Ala Gly Glu Leu Gly Leu Gly Gly 
        35                  40                  45              


Ala Gly Thr Arg Leu Asn Gly Leu Gly Gly Leu Thr Gly Gly Gly Ser 
    50                  55                  60                  


Gly Ser Gly Cys Thr Leu Ser Pro Pro Gln Gly Cys Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Ile Ala Leu Ser Pro Pro Pro Ser Cys Gly Val Gly Thr Leu 
                85                  90                  95      


Leu Ser Thr Pro Ala Ala Ala Thr Ser Ser Ser Pro Ser Ser Ser Ser 
            100                 105                 110         


Ala Ala Ser Ser Ser Ser Pro Gly Ser Arg Lys Met Val Val Ser Ala 
        115                 120                 125             


Glu Met Cys Cys Phe Cys Phe Asp Val Leu Tyr Cys His Leu Tyr Gly 
    130                 135                 140                 


Tyr Gln Gln Pro Arg Thr Pro Arg Phe Thr Asn Glu Pro Tyr Pro Leu 
145                 150                 155                 160 


Phe Val Thr Trp Lys Ile Gly Arg Asp Lys Arg Leu Arg Gly Cys Ile 
                165                 170                 175     


Gly Thr Phe Ser Ala Met Asn Leu His Ser Gly Leu Arg Glu Tyr Thr 
            180                 185                 190         


Leu Thr Ser Ala Leu Lys Asp Ser Arg Phe Pro Pro Met Thr Arg Asp 
        195                 200                 205             


Glu Leu Pro Arg Leu Phe Cys Ser Val Ser Leu Leu Thr Asn Phe Glu 
    210                 215                 220                 


Asp Val Cys Asp Tyr Leu Asp Trp Glu Val Gly Val His Gly Ile Arg 
225                 230                 235                 240 


Ile Glu Phe Ile Asn Glu Lys Gly Ser Lys Arg Thr Ala Thr Tyr Leu 
                245                 250                 255     


Pro Glu Val Ala Lys Glu Gln Gly Trp Asp His Ile Gln Thr Ile Asp 
            260                 265                 270         


Ser Leu Leu Arg Lys Gly Gly Tyr Lys Ala Pro Ile Thr Asn Glu Phe 
        275                 280                 285             


Arg Lys Thr Ile Lys Leu Thr Arg Tyr Arg Ser Glu Lys Met Thr Leu 
    290                 295                 300                 


Ser Tyr Ala Glu Tyr Leu Ala His Arg Gln His His His Phe Gln Asn 
305                 310                 315                 320 


Gly Ile Gly His Pro Leu Pro Pro Tyr Asn His Tyr Ser 
                325                 330             


<210>  134
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Val Val Ser Ala Glu Met Cys Cys Phe Cys Phe Asp Val Leu Tyr 
1               5                   10                  15      


Cys His Leu Tyr Gly Tyr Gln Gln Pro Arg Thr Pro Arg Phe Thr Asn 
            20                  25                  30          


Glu Pro Tyr Pro Leu Phe Val Thr Trp Lys Ile Gly Arg Asp Lys Arg 
        35                  40                  45              


Leu Arg Gly Cys Ile Gly Thr Phe Ser Ala Met Asn Leu His Ser Gly 
    50                  55                  60                  


Leu Arg Glu Tyr Thr Leu Thr Ser Ala Leu Lys Asp Ser Arg Phe Pro 
65                  70                  75                  80  


Pro Met Thr Arg Asp Glu Leu Pro Arg Leu Phe Cys Ser Val Ser Leu 
                85                  90                  95      


Leu Thr Asn Phe Glu Asp Val Cys Asp Tyr Leu Asp Trp Glu Val Gly 
            100                 105                 110         


Val His Gly Ile Arg Ile Glu Phe Ile Asn Glu Lys Gly Ser Lys Arg 
        115                 120                 125             


Thr Ala Thr Tyr Leu Pro Glu Val Ala Lys Glu Gln Gly Trp Asp His 
    130                 135                 140                 


Ile Gln Thr Ile Asp Ser Leu Leu Arg Lys Gly Gly Tyr Lys Ala Pro 
145                 150                 155                 160 


Ile Thr Asn Glu Phe Arg Lys Thr Ile Lys Leu Thr Arg Tyr Arg Ser 
                165                 170                 175     


Glu Lys Met Thr Leu Ser Tyr Ala Glu Tyr Leu Ala His Arg Gln His 
            180                 185                 190         


His His Phe Gln Asn Gly Ile Gly His Pro Leu Pro Pro Tyr Asn His 
        195                 200                 205             


Tyr Ser 
    210 


<210>  135
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  135

Met Ala Ala Gly Cys Cys Gly Val Lys Lys Gln Lys Leu Ser Ser Ser 
1               5                   10                  15      


Pro Pro Ser Gly Ser Gly Gly Gly Gly Gly Ala Ser Ser Ser Ser His 
            20                  25                  30          


Cys Ser Gly Glu Ser Gln Cys Arg Ala Gly Glu Leu Gly Leu Gly Gly 
        35                  40                  45              


Ala Gly Thr Arg Leu Asn Gly Leu Gly Gly Leu Thr Gly Gly Gly Ser 
    50                  55                  60                  


Gly Ser Gly Cys Thr Leu Ser Pro Pro Gln Gly Cys Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Ile Ala Leu Ser Pro Pro Pro Ser Cys Gly Val Gly Thr Leu 
                85                  90                  95      


Leu Ser Thr Pro Ala Ala Ala Thr Ser Ser Ser Pro Ser Ser Ser Ser 
            100                 105                 110         


Ala Ala Ser Ser Ser Ser Pro Gly Ser Arg Lys Met Val Val Ser Ala 
        115                 120                 125             


Glu Met Cys Cys Phe Cys Phe Asp Val Leu Tyr Cys His Leu Tyr Gly 
    130                 135                 140                 


Tyr Gln Gln Pro Arg Thr Pro Arg Phe Thr Asn Glu Pro Tyr Ala Leu 
145                 150                 155                 160 


Lys Asp Ser Arg Phe Pro Pro Met Thr Arg Asp Glu Leu Pro Arg Leu 
                165                 170                 175     


Phe Cys Ser Val Ser Leu Leu Thr Asn Phe Glu Asp Val Cys Asp Tyr 
            180                 185                 190         


Leu Asp Trp Glu Val Gly Val His Gly Ile Arg Ile Glu Phe Ile Asn 
        195                 200                 205             


Glu Lys Gly Ser Lys Arg Thr Ala Thr Tyr Leu Pro Glu Val Ala Lys 
    210                 215                 220                 


Glu Gln Gly Trp Asp His Ile Gln Thr Ile Asp Ser Leu Leu Arg Lys 
225                 230                 235                 240 


Gly Gly Tyr Lys Ala Pro Ile Thr Asn Glu Phe Arg Lys Thr Ile Lys 
                245                 250                 255     


Leu Thr Arg Tyr Arg Ser Glu Lys Met Thr Leu Ser Tyr Ala Glu Tyr 
            260                 265                 270         


Leu Ala His Arg Gln His His His Phe Gln Asn Gly Ile Gly His Pro 
        275                 280                 285             


Leu Pro Pro Tyr Asn His Tyr Ser 
    290                 295     


<210>  136
<211>  888
<212>  PRT
<213>  Homo sapiens

<400>  136

Met Leu Ser Arg Leu Phe Arg Met His Gly Leu Phe Val Ala Ser His 
1               5                   10                  15      


Pro Trp Glu Val Ile Val Gly Thr Val Thr Leu Thr Ile Cys Met Met 
            20                  25                  30          


Ser Met Asn Met Phe Thr Gly Asn Asn Lys Ile Cys Gly Trp Asn Tyr 
        35                  40                  45              


Glu Cys Pro Lys Phe Glu Glu Asp Val Leu Ser Ser Asp Ile Ile Ile 
    50                  55                  60                  


Leu Thr Ile Thr Arg Cys Ile Ala Ile Leu Tyr Ile Tyr Phe Gln Phe 
65                  70                  75                  80  


Gln Asn Leu Arg Gln Leu Gly Ser Lys Tyr Ile Leu Gly Ile Ala Gly 
                85                  90                  95      


Leu Phe Thr Ile Phe Ser Ser Phe Val Phe Ser Thr Val Val Ile His 
            100                 105                 110         


Phe Leu Asp Lys Glu Leu Thr Gly Leu Asn Glu Ala Leu Pro Phe Phe 
        115                 120                 125             


Leu Leu Leu Ile Asp Leu Ser Arg Ala Ser Thr Leu Ala Lys Phe Ala 
    130                 135                 140                 


Leu Ser Ser Asn Ser Gln Asp Glu Val Arg Glu Asn Ile Ala Arg Gly 
145                 150                 155                 160 


Met Ala Ile Leu Gly Pro Thr Phe Thr Leu Asp Ala Leu Val Glu Cys 
                165                 170                 175     


Leu Val Ile Gly Val Gly Thr Met Ser Gly Val Arg Gln Leu Glu Ile 
            180                 185                 190         


Met Cys Cys Phe Gly Cys Met Ser Val Leu Ala Asn Tyr Phe Val Phe 
        195                 200                 205             


Met Thr Phe Phe Pro Ala Cys Val Ser Leu Val Leu Glu Leu Ser Arg 
    210                 215                 220                 


Glu Ser Arg Glu Gly Arg Pro Ile Trp Gln Leu Ser His Phe Ala Arg 
225                 230                 235                 240 


Val Leu Glu Glu Glu Glu Asn Lys Pro Asn Pro Val Thr Gln Arg Val 
                245                 250                 255     


Lys Met Ile Met Ser Leu Gly Leu Val Leu Val His Ala His Ser Arg 
            260                 265                 270         


Trp Ile Ala Asp Pro Ser Pro Gln Asn Ser Thr Ala Asp Thr Ser Lys 
        275                 280                 285             


Val Ser Leu Gly Leu Asp Glu Asn Val Ser Lys Arg Ile Glu Pro Ser 
    290                 295                 300                 


Val Ser Leu Trp Gln Phe Tyr Leu Ser Lys Met Ile Ser Met Asp Ile 
305                 310                 315                 320 


Glu Gln Val Ile Thr Leu Ser Leu Ala Leu Leu Leu Ala Val Lys Tyr 
                325                 330                 335     


Ile Phe Phe Glu Gln Thr Glu Thr Glu Ser Thr Leu Ser Leu Lys Asn 
            340                 345                 350         


Pro Ile Thr Ser Pro Val Val Thr Gln Lys Lys Val Pro Asp Asn Cys 
        355                 360                 365             


Cys Arg Arg Glu Pro Met Leu Val Arg Asn Asn Gln Lys Cys Asp Ser 
    370                 375                 380                 


Val Glu Glu Glu Thr Gly Ile Asn Arg Glu Arg Lys Val Glu Val Ile 
385                 390                 395                 400 


Lys Pro Leu Val Ala Glu Thr Asp Thr Pro Asn Arg Ala Thr Phe Val 
                405                 410                 415     


Val Gly Asn Ser Ser Leu Leu Asp Thr Ser Ser Val Leu Val Thr Gln 
            420                 425                 430         


Glu Pro Glu Ile Glu Leu Pro Arg Glu Pro Arg Pro Asn Glu Glu Cys 
        435                 440                 445             


Leu Gln Ile Leu Gly Asn Ala Glu Lys Gly Ala Lys Phe Leu Ser Asp 
    450                 455                 460                 


Ala Glu Ile Ile Gln Leu Val Asn Ala Lys His Ile Pro Ala Tyr Lys 
465                 470                 475                 480 


Leu Glu Thr Leu Met Glu Thr His Glu Arg Gly Val Ser Ile Arg Arg 
                485                 490                 495     


Gln Leu Leu Ser Lys Lys Leu Ser Glu Pro Ser Ser Leu Gln Tyr Leu 
            500                 505                 510         


Pro Tyr Arg Asp Tyr Asn Tyr Ser Leu Val Met Gly Ala Cys Cys Glu 
        515                 520                 525             


Asn Val Ile Gly Tyr Met Pro Ile Pro Val Gly Val Ala Gly Pro Leu 
    530                 535                 540                 


Cys Leu Asp Glu Lys Glu Phe Gln Val Pro Met Ala Thr Thr Glu Gly 
545                 550                 555                 560 


Cys Leu Val Ala Ser Thr Asn Arg Gly Cys Arg Ala Ile Gly Leu Gly 
                565                 570                 575     


Gly Gly Ala Ser Ser Arg Val Leu Ala Asp Gly Met Thr Arg Gly Pro 
            580                 585                 590         


Val Val Arg Leu Pro Arg Ala Cys Asp Ser Ala Glu Val Lys Ala Trp 
        595                 600                 605             


Leu Glu Thr Ser Glu Gly Phe Ala Val Ile Lys Glu Ala Phe Asp Ser 
    610                 615                 620                 


Thr Ser Arg Phe Ala Arg Leu Gln Lys Leu His Thr Ser Ile Ala Gly 
625                 630                 635                 640 


Arg Asn Leu Tyr Ile Arg Phe Gln Ser Arg Ser Gly Asp Ala Met Gly 
                645                 650                 655     


Met Asn Met Ile Ser Lys Gly Thr Glu Lys Ala Leu Ser Lys Leu His 
            660                 665                 670         


Glu Tyr Phe Pro Glu Met Gln Ile Leu Ala Val Ser Gly Asn Tyr Cys 
        675                 680                 685             


Thr Asp Lys Lys Pro Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys 
    690                 695                 700                 


Ser Val Val Cys Glu Ala Val Ile Pro Ala Lys Val Val Arg Glu Val 
705                 710                 715                 720 


Leu Lys Thr Thr Thr Glu Ala Met Ile Glu Val Asn Ile Asn Lys Asn 
                725                 730                 735     


Leu Val Gly Ser Ala Met Ala Gly Ser Ile Gly Gly Tyr Asn Ala His 
            740                 745                 750         


Ala Ala Asn Ile Val Thr Ala Ile Tyr Ile Ala Cys Gly Gln Asp Ala 
        755                 760                 765             


Ala Gln Asn Val Gly Ser Ser Asn Cys Ile Thr Leu Met Glu Ala Ser 
    770                 775                 780                 


Gly Pro Thr Asn Glu Asp Leu Tyr Ile Ser Cys Thr Met Pro Ser Ile 
785                 790                 795                 800 


Glu Ile Gly Thr Val Gly Gly Gly Thr Asn Leu Leu Pro Gln Gln Ala 
                805                 810                 815     


Cys Leu Gln Met Leu Gly Val Gln Gly Ala Cys Lys Asp Asn Pro Gly 
            820                 825                 830         


Glu Asn Ala Arg Gln Leu Ala Arg Ile Val Cys Gly Thr Val Met Ala 
        835                 840                 845             


Gly Glu Leu Ser Leu Met Ala Ala Leu Ala Ala Gly His Leu Val Lys 
    850                 855                 860                 


Ser His Met Ile His Asn Arg Ser Lys Ile Asn Leu Gln Asp Leu Gln 
865                 870                 875                 880 


Gly Ala Cys Thr Lys Lys Thr Ala 
                885             


<210>  137
<211>  835
<212>  PRT
<213>  Homo sapiens

<400>  137

Met Leu Ser Arg Leu Phe Arg Met His Gly Leu Phe Val Ala Ser His 
1               5                   10                  15      


Pro Trp Glu Val Ile Val Gly Thr Val Thr Leu Thr Ile Cys Met Met 
            20                  25                  30          


Ser Met Asn Met Phe Thr Gly Asn Asn Lys Ile Cys Gly Trp Asn Tyr 
        35                  40                  45              


Glu Cys Pro Lys Phe Glu Glu Asp Val Leu Ser Ser Asp Ile Ile Ile 
    50                  55                  60                  


Leu Thr Ile Thr Arg Cys Ile Ala Ile Leu Tyr Ile Tyr Phe Gln Phe 
65                  70                  75                  80  


Gln Asn Leu Arg Gln Leu Gly Ser Lys Tyr Ile Leu Gly Ile Ala Gly 
                85                  90                  95      


Leu Phe Thr Ile Phe Ser Ser Phe Val Phe Ser Thr Val Val Ile His 
            100                 105                 110         


Phe Leu Asp Lys Glu Leu Thr Gly Leu Asn Glu Ala Leu Pro Phe Phe 
        115                 120                 125             


Leu Leu Leu Ile Asp Leu Ser Arg Ala Ser Thr Leu Ala Lys Phe Ala 
    130                 135                 140                 


Leu Ser Ser Asn Ser Gln Asp Glu Val Arg Glu Asn Ile Ala Arg Gly 
145                 150                 155                 160 


Met Ala Ile Leu Gly Pro Thr Phe Thr Leu Asp Ala Leu Val Glu Cys 
                165                 170                 175     


Leu Val Ile Gly Val Gly Thr Met Ser Gly Val Arg Gln Leu Glu Ile 
            180                 185                 190         


Met Cys Cys Phe Gly Cys Met Ser Val Leu Ala Asn Tyr Phe Val Phe 
        195                 200                 205             


Met Thr Phe Phe Pro Ala Cys Val Ser Leu Val Leu Glu Leu Ser Arg 
    210                 215                 220                 


Glu Ser Arg Glu Gly Arg Pro Ile Trp Gln Leu Ser His Phe Ala Arg 
225                 230                 235                 240 


Val Leu Glu Glu Glu Glu Asn Lys Pro Asn Pro Val Thr Gln Arg Val 
                245                 250                 255     


Lys Met Ile Met Ser Leu Gly Leu Val Leu Val His Ala His Ser Arg 
            260                 265                 270         


Trp Ile Ala Asp Pro Ser Pro Gln Asn Ser Thr Ala Asp Thr Ser Lys 
        275                 280                 285             


Val Ser Leu Gly Leu Asp Glu Asn Val Ser Lys Arg Ile Glu Pro Ser 
    290                 295                 300                 


Val Ser Leu Trp Gln Phe Tyr Leu Ser Lys Met Ile Ser Met Asp Ile 
305                 310                 315                 320 


Glu Gln Val Ile Thr Leu Ser Leu Ala Leu Leu Leu Ala Val Lys Tyr 
                325                 330                 335     


Ile Phe Phe Glu Gln Thr Glu Thr Glu Ser Thr Leu Ser Leu Lys Asn 
            340                 345                 350         


Pro Ile Thr Ser Pro Val Val Thr Gln Lys Lys Val Pro Asp Asn Cys 
        355                 360                 365             


Cys Arg Arg Glu Pro Met Leu Val Arg Asn Asn Gln Lys Cys Asp Ser 
    370                 375                 380                 


Val Glu Glu Glu Thr Gly Ile Asn Arg Glu Arg Lys Val Glu Val Ile 
385                 390                 395                 400 


Lys Pro Leu Val Ala Glu Thr Asp Thr Pro Asn Arg Ala Thr Phe Val 
                405                 410                 415     


Val Gly Asn Ser Ser Leu Leu Asp Thr Ser Ser Val Leu Val Thr Gln 
            420                 425                 430         


Glu Pro Glu Ile Glu Leu Pro Arg Glu Pro Arg Pro Asn Glu Glu Cys 
        435                 440                 445             


Leu Gln Ile Leu Gly Asn Ala Glu Lys Gly Ala Lys Phe Leu Ser Asp 
    450                 455                 460                 


Ala Glu Ile Ile Gln Leu Val Asn Ala Lys His Ile Pro Ala Tyr Lys 
465                 470                 475                 480 


Leu Glu Thr Leu Met Glu Thr His Glu Arg Gly Val Ser Ile Arg Arg 
                485                 490                 495     


Gln Leu Leu Ser Lys Lys Leu Ser Glu Pro Ser Ser Leu Gln Tyr Leu 
            500                 505                 510         


Pro Tyr Arg Asp Tyr Asn Tyr Ser Leu Leu Gly Gly Gly Ala Ser Ser 
        515                 520                 525             


Arg Val Leu Ala Asp Gly Met Thr Arg Gly Pro Val Val Arg Leu Pro 
    530                 535                 540                 


Arg Ala Cys Asp Ser Ala Glu Val Lys Ala Trp Leu Glu Thr Ser Glu 
545                 550                 555                 560 


Gly Phe Ala Val Ile Lys Glu Ala Phe Asp Ser Thr Ser Arg Phe Ala 
                565                 570                 575     


Arg Leu Gln Lys Leu His Thr Ser Ile Ala Gly Arg Asn Leu Tyr Ile 
            580                 585                 590         


Arg Phe Gln Ser Arg Ser Gly Asp Ala Met Gly Met Asn Met Ile Ser 
        595                 600                 605             


Lys Gly Thr Glu Lys Ala Leu Ser Lys Leu His Glu Tyr Phe Pro Glu 
    610                 615                 620                 


Met Gln Ile Leu Ala Val Ser Gly Asn Tyr Cys Thr Asp Lys Lys Pro 
625                 630                 635                 640 


Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys Ser Val Val Cys Glu 
                645                 650                 655     


Ala Val Ile Pro Ala Lys Val Val Arg Glu Val Leu Lys Thr Thr Thr 
            660                 665                 670         


Glu Ala Met Ile Glu Val Asn Ile Asn Lys Asn Leu Val Gly Ser Ala 
        675                 680                 685             


Met Ala Gly Ser Ile Gly Gly Tyr Asn Ala His Ala Ala Asn Ile Val 
    690                 695                 700                 


Thr Ala Ile Tyr Ile Ala Cys Gly Gln Asp Ala Ala Gln Asn Val Gly 
705                 710                 715                 720 


Ser Ser Asn Cys Ile Thr Leu Met Glu Ala Ser Gly Pro Thr Asn Glu 
                725                 730                 735     


Asp Leu Tyr Ile Ser Cys Thr Met Pro Ser Ile Glu Ile Gly Thr Val 
            740                 745                 750         


Gly Gly Gly Thr Asn Leu Leu Pro Gln Gln Ala Cys Leu Gln Met Leu 
        755                 760                 765             


Gly Val Gln Gly Ala Cys Lys Asp Asn Pro Gly Glu Asn Ala Arg Gln 
    770                 775                 780                 


Leu Ala Arg Ile Val Cys Gly Thr Val Met Ala Gly Glu Leu Ser Leu 
785                 790                 795                 800 


Met Ala Ala Leu Ala Ala Gly His Leu Val Lys Ser His Met Ile His 
                805                 810                 815     


Asn Arg Ser Lys Ile Asn Leu Gln Asp Leu Gln Gly Ala Cys Thr Lys 
            820                 825                 830         


Lys Thr Ala 
        835 


<210>  138
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Leu Ser Arg Leu Phe Arg Met His Gly Leu Phe Val Ala Ser His 
1               5                   10                  15      


Pro Trp 
        


<210>  139
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  139

Tyr Phe Pro Glu Met Gln Ile Leu Ala Val Ser Gly Asn Tyr Cys Thr 
1               5                   10                  15      


Asp Lys Lys Pro Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys Ser 
            20                  25                  30          


Val Val Cys Glu Ala Val Ile Pro Ala Lys Val Val Arg Glu Met Leu 
        35                  40                  45              


Gly Val Gln Gly Ala Cys Lys Asp Asn Pro Gly Glu Asn Ala Arg Gln 
    50                  55                  60                  


Leu Ala Arg Ile Val Cys Gly Thr Val Met Ala Gly Glu Leu Ser Leu 
65                  70                  75                  80  


Met Ala Ala Leu Ala Ala Gly His Leu Val Lys Ser His Met Ile His 
                85                  90                  95      


Asn Arg Ser Lys Ile Asn Leu Gln Asp Leu Gln Gly Ala Cys Thr Lys 
            100                 105                 110         


Lys Thr Ala 
        115 


<210>  140
<211>  165
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  140

Xaa His Glu Tyr Phe Pro Glu Met Gln Ile Leu Ala Val Ser Gly Asn 
1               5                   10                  15      


Tyr Cys Thr Asp Lys Lys Pro Ala Ala Ile Asn Trp Ile Glu Gly Arg 
            20                  25                  30          


Gly Lys Ser Val Val Cys Glu Ala Val Ile Pro Ala Lys Val Val Arg 
        35                  40                  45              


Glu Val Leu Lys Thr Thr Thr Glu Ala Met Ile Glu Val Asn Ile Asn 
    50                  55                  60                  


Lys Asn Leu Val Gly Ser Ala Met Ala Gly Ser Ile Gly Gly Tyr Asn 
65                  70                  75                  80  


Ala His Ala Ala Asn Ile Val Thr Ala Ile Tyr Ile Ala Cys Gly Gln 
                85                  90                  95      


Met Leu Gly Val Gln Gly Ala Cys Lys Asp Asn Pro Gly Glu Asn Ala 
            100                 105                 110         


Arg Gln Leu Ala Arg Ile Val Cys Gly Thr Val Met Ala Gly Glu Leu 
        115                 120                 125             


Ser Leu Met Ala Ala Leu Ala Ala Gly His Leu Val Lys Ser His Met 
    130                 135                 140                 


Ile His Asn Arg Ser Lys Ile Asn Leu Gln Asp Leu Gln Gly Ala Cys 
145                 150                 155                 160 


Thr Lys Lys Thr Ala 
                165 


<210>  141
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  141

Met Leu Ser Arg Leu Phe Arg Met His Gly Leu Phe Val Ala Ser His 
1               5                   10                  15      


Pro Trp Glu Val Ile Val Gly Thr Val Thr Leu Thr Ile Cys Met Met 
            20                  25                  30          


Ser Met Asn Met Phe Thr Gly Asn Asn Lys Ile Cys Gly Trp Asn Tyr 
        35                  40                  45              


Glu Cys Pro Lys Phe Glu Glu Asp Val Leu Ser Ser Asp Ile Ile Ile 
    50                  55                  60                  


Leu Thr Ile Thr Arg Cys Ile Ala Ile Leu Tyr Ile Tyr Phe Gln Phe 
65                  70                  75                  80  


Gln Asn Leu Arg Gln Leu Gly Ser Lys Tyr Ile Leu Gly Ile Ala Gly 
                85                  90                  95      


Leu Phe Thr Ile Phe Ser Ser Phe Val Phe Ser Thr Val Val Ile 
            100                 105                 110     


<210>  142
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  142

Met His Gln Gln Lys Arg Gln Pro Glu Leu Val Glu Gly Asn Leu Pro 
1               5                   10                  15      


Val Phe Val Phe Pro Thr Glu Leu Ile Phe Tyr Ala Asp Asp Gln Ser 
            20                  25                  30          


Thr His Lys Gln Val Leu Thr Leu Tyr Asn Pro Tyr Glu Phe Ala Leu 
        35                  40                  45              


Lys Phe Lys Val Leu Cys Thr Thr Pro Asn Lys Tyr Val Val Val Asp 
    50                  55                  60                  


Ala Ala Gly Ala Val Lys Pro Gln Cys Cys Val Asp Ile Val Ile Arg 
65                  70                  75                  80  


His Arg Asp Val Arg Ser Cys His Tyr Gly Val Ile Asp Lys Phe Arg 
                85                  90                  95      


Leu Gln Val Ser Glu Gln Ser Gln Arg Lys Ala Leu Gly Arg Lys Glu 
            100                 105                 110         


Val Val Ala Thr Leu Leu Pro Ser Ala Lys Glu Gln Gln Lys Glu Glu 
        115                 120                 125             


Glu Glu Lys Arg Leu Lys Glu His Leu Thr Glu Ser Leu Phe Phe Glu 
    130                 135                 140                 


Gln Ser Phe Gln Pro Glu Asn Arg Ala Val Ser Ser Gly Pro Ser Leu 
145                 150                 155                 160 


Leu Thr Val Phe Leu Gly Val Val Cys Ile Ala Ala Leu Met Leu Pro 
                165                 170                 175     


Thr Leu Gly Asp Val Glu Ser Leu Val Pro Leu Tyr Leu His Leu Ser 
            180                 185                 190         


Val Asn Gln Lys Leu Val Ala Ala Tyr Ile Leu Gly Leu Ile Thr Met 
        195                 200                 205             


Ala Ile Leu Arg Thr 
    210             


<210>  143
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  143

Met His Gln Gln Lys Arg Gln Pro Glu Leu Val Glu Gly Asn Leu Pro 
1               5                   10                  15      


Val Phe Val Phe Pro Thr Glu Leu Ile Phe Tyr Ala Asp Asp Gln Ser 
            20                  25                  30          


Thr His Lys Gln Val Leu Thr Leu Tyr Asn Pro Tyr Glu Phe Ala Leu 
        35                  40                  45              


Lys Phe Lys Val Leu Cys Thr Thr Pro Asn Lys Tyr Val Val Val Asp 
    50                  55                  60                  


Ala Ala Gly Ala Val Lys Pro Gln Cys Cys Val Asp Ile Val Ile Arg 
65                  70                  75                  80  


His Arg Asp Val Arg Ser Cys His Tyr Gly Val Ile Asp Lys Phe Arg 
                85                  90                  95      


Leu Gln Val Ser Glu Gln Ser Gln Arg Lys Ala Leu Gly Arg Lys Glu 
            100                 105                 110         


Val Val Ala Thr Leu Leu Pro Ser Ala Lys Glu Gln Gln Lys Glu Glu 
        115                 120                 125             


Glu Glu Lys Arg Leu Lys Glu His Leu Thr Glu Ser Leu Phe Phe Glu 
    130                 135                 140                 


Gln Ser Phe Gln Pro Gly Lys Asn Arg Ala Val Ser Ser Gly Pro Ser 
145                 150                 155                 160 


Leu Leu Thr Val Phe Leu Gly Val Val Cys Ile Ala Ala Leu Met Leu 
                165                 170                 175     


Pro Thr Leu Gly Asp Val Glu Ser Leu Val Pro Leu Tyr Leu His Leu 
            180                 185                 190         


Ser Val Asn Gln Lys Leu Val Ala Ala Tyr Ile Leu Gly Leu Ile Thr 
        195                 200                 205             


Met Ala Ile Leu Arg Thr 
    210                 


<210>  144
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  144

Met His Gln Gln Lys Arg Gln Pro Glu Leu Val Glu Gly Asn Leu Pro 
1               5                   10                  15      


Val Phe Val Phe Pro Thr Glu Leu Ile Phe Tyr Ala Asp Asp Gln Ser 
            20                  25                  30          


Thr His Lys Gln Val Leu Thr Leu Tyr Asn Pro Tyr Glu Phe Ala Leu 
        35                  40                  45              


Lys Phe Lys Val Leu Cys Thr Thr Pro Asn Lys Tyr Val Val Val Asp 
    50                  55                  60                  


Ala Ala Gly Ala Val Lys Pro Gln Cys Cys Val Asp Ile Val Ile Arg 
65                  70                  75                  80  


His Arg Asp Val Arg Ser Cys His Tyr Gly Val Ile Asp Lys Phe Arg 
                85                  90                  95      


Leu Gln Val Ser Glu Gln Ser Gln Arg Lys Ala Leu Gly Arg Lys Glu 
            100                 105                 110         


Val Val Ala Thr Leu Leu Pro Ser Ala Lys Glu Gln Gln Lys Glu Glu 
        115                 120                 125             


Glu Glu Lys Arg Leu Lys Glu His Leu Thr Glu Ser Leu Phe Phe Glu 
    130                 135                 140                 


Gln Ser Phe Gln Pro Gly Leu Ile Thr Met Ala Ile Leu Arg Thr 
145                 150                 155                 


<210>  145
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  145

Met Glu Leu Ile Gln Asp Ile Ser Arg Pro Pro Leu Glu Tyr Val Lys 
1               5                   10                  15      


Gly Val Pro Leu Ile Lys Tyr Phe Ala Glu Ala Leu Gly Pro Leu Gln 
            20                  25                  30          


Ser Phe Gln Ala Arg Pro Asp Asp Leu Leu Ile Ser Thr Tyr Pro Lys 
        35                  40                  45              


Ser Gly Thr Thr Trp Val Ser Gln Ile Leu Asp Met Ile Tyr Gln Gly 
    50                  55                  60                  


Gly Asp Leu Glu Lys Cys His Arg Ala Pro Ile Phe Met Arg Val Pro 
65                  70                  75                  80  


Phe Leu Glu Phe Lys Val Pro Gly Ile Pro Ser Gly Met Glu Thr Leu 
                85                  90                  95      


Lys Asn Thr Pro Ala Pro Arg Leu Leu Lys Thr His Leu Pro Leu Ala 
            100                 105                 110         


Leu Leu Pro Gln Thr Leu Leu Asp Gln Lys Val Lys Val Val Tyr Val 
        115                 120                 125             


Ala Arg Asn Ala Lys Asp Val Ala Val Ser Tyr Tyr His Phe Tyr His 
    130                 135                 140                 


Met Ala Lys Val Tyr Pro His Pro Gly Thr Trp Glu Ser Phe Leu Glu 
145                 150                 155                 160 


Lys Phe Met Ala Gly Glu Val Ser Tyr Gly Ser Trp Tyr Gln His Val 
                165                 170                 175     


Gln Glu Trp Trp Glu Leu Ser Arg Thr His Pro Val Leu Tyr Leu Phe 
            180                 185                 190         


Tyr Glu Asp Met Lys Glu Asn Pro Lys Arg Glu Ile Gln Lys Ile Leu 
        195                 200                 205             


Glu Phe Val Gly Arg Ser Leu Pro Glu Glu Thr Val Asp Leu Met Val 
    210                 215                 220                 


Glu His Thr Ser Phe Lys Glu Met Lys Lys Asn Pro Met Thr Asn Tyr 
225                 230                 235                 240 


Thr Thr Val Arg Arg Glu Phe Met Asp His Ser Ile Ser Pro Phe Met 
                245                 250                 255     


Arg Lys Gly Met Ala Gly Asp Trp Lys Thr Thr Phe Thr Val Ala Gln 
            260                 265                 270         


Asn Glu Arg Phe Asp Ala Asp Tyr Ala Lys Lys Met Ala Gly Cys Ser 
        275                 280                 285             


Leu Ser Phe Arg Ser Glu Leu 
    290                 295 


<210>  146
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  146

Met Glu Leu Ile Gln Asp Ile Ser Arg Pro Pro Leu Glu Tyr Val Lys 
1               5                   10                  15      


Gly Val Pro Leu Ile Lys Tyr Phe Ala Glu Ala Leu Gly Pro Leu Gln 
            20                  25                  30          


Ser Phe Gln Ala Arg Pro Asp Asp Leu Leu Ile Ser Thr Tyr Pro Lys 
        35                  40                  45              


Ser Gly Thr Thr Trp Val Ser Gln Ile Leu Asp Met Ile Tyr Gln Gly 
    50                  55                  60                  


Gly Asp Leu Glu Lys Cys His Arg Ala Pro Ile Phe Met Arg Val Pro 
65                  70                  75                  80  


Phe Leu Glu Phe Lys Val Pro Gly Ile Pro Ser Gly Val Cys Val Leu 
                85                  90                  95      


Gly Ala Arg Gly Val Glu Glu Asp Arg Ala Gly Ala Ser Ala His Gln 
            100                 105                 110         


Thr Phe Pro Asp Pro Leu Leu Arg Asp Gly Asp Ser Glu Lys His Thr 
        115                 120                 125             


Ser Pro Thr Thr Pro Glu Asp Thr Pro Ala Pro Gly Ser Ala Pro Pro 
    130                 135                 140                 


Asp Ser Val Gly Ser Glu Gly Gln Gly Gly Leu Cys Cys Pro Gln Arg 
145                 150                 155                 160 


Lys Gly Cys Gly Gly Phe Leu Leu Pro Leu Leu Pro His Gly Gln Ser 
                165                 170                 175     


Val Pro Ser Pro Trp Asp Leu Gly Lys Leu Pro Gly Glu Val His Gly 
            180                 185                 190         


Trp Arg Ser Val Leu Trp Val Leu Val Pro Ala Arg Ala Arg Val Val 
        195                 200                 205             


Gly Ala Glu Pro His Pro Pro Cys Ser Leu Pro Leu Leu 
    210                 215                 220     


<210>  147
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  147

Met Glu Leu Ile Gln Asp Ile Ser Arg Pro Pro Leu Glu Tyr Val Lys 
1               5                   10                  15      


Gly Val Pro Leu Ile Lys Tyr Phe Ala Glu Ala Leu Gly Pro Leu Gln 
            20                  25                  30          


Ser Phe Gln Ala Arg Pro Asp Asp Leu Leu Ile Ser Thr Tyr Pro Lys 
        35                  40                  45              


Ser Gly Thr Thr Trp Val Ser Gln Ile Leu Asp Met Ile Tyr Gln Gly 
    50                  55                  60                  


Gly Asp Leu Glu Lys Cys His Arg Ala Pro Ile Phe Met Arg Val Pro 
65                  70                  75                  80  


Phe Leu Glu Phe Lys Val Pro Gly Ile Pro Ser Gly Met Glu Thr Leu 
                85                  90                  95      


Lys Asn Thr Pro Ala Pro Arg Leu Leu Lys Thr His Leu Pro Leu Ala 
            100                 105                 110         


Leu Leu Pro Gln Thr Leu Leu Asp Gln Lys Val Lys Val Val Tyr Val 
        115                 120                 125             


Ala Arg Asn Ala Lys Asp Val Ala Val Ser Tyr Tyr His Phe Tyr His 
    130                 135                 140                 


Met Ala Lys Val Tyr Pro His Pro Gly Thr Trp Glu Ser Phe Leu Glu 
145                 150                 155                 160 


Lys Phe Met Ala Gly Glu Val Ser Tyr Gly Ser Trp Tyr Gln His Val 
                165                 170                 175     


Gln Glu Trp Trp Glu Leu Ser Arg Thr His Pro Val Leu Tyr Leu Phe 
            180                 185                 190         


<210>  148
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  148

Met Glu Leu Ile Gln Asp Ile Ser Arg Pro Pro Leu Glu Tyr Val Lys 
1               5                   10                  15      


Gly Val Pro Leu Ile Lys Tyr Phe Ala Glu Ala Leu Gly Pro Leu Gln 
            20                  25                  30          


Ser Phe Gln Ala Arg Pro Asp Asp Leu Leu Ile Ser Thr Tyr Pro Lys 
        35                  40                  45              


Ser Gly Thr Thr Trp Val Ser Gln Ile Leu Asp Met Ile Tyr Gln Gly 
    50                  55                  60                  


Gly Asp Leu Glu Lys Cys His Arg Ala Pro Ile Phe Met Arg Val Pro 
65                  70                  75                  80  


Phe Leu Glu Phe Lys Val Pro Gly Ile Pro Ser Gly Val Cys Val Leu 
                85                  90                  95      


Gly Ala Arg Gly Val Glu Glu Asp Arg Ala Gly Ala Ser Ala His Gln 
            100                 105                 110         


Thr Phe Pro Asp Pro Leu Leu Arg Asp Gly Asp Ser Glu Lys His Thr 
        115                 120                 125             


Ser Pro Thr Thr Pro Glu Asp Thr Pro Ala Pro Gly Ser Ala Pro Pro 
    130                 135                 140                 


Asp Ser Val Gly Ser Glu Gly Gln Ala Ile Gln Ala Ser Thr Glu Glu 
145                 150                 155                 160 


Pro Ser Ala Ala Gln Asn Pro Lys Arg Glu Ile Gln Lys Ile Leu Glu 
                165                 170                 175     


Phe Val Gly Arg Ser Leu Pro Glu Glu Thr Val Asp Leu Met Val Glu 
            180                 185                 190         


His Thr Ser Phe Lys Glu Met Lys Lys Asn Pro Met Thr Asn Tyr Thr 
        195                 200                 205             


Thr Val Arg Arg Glu Phe Met Asp His Ser Ile Ser Pro Phe Met Arg 
    210                 215                 220                 


Lys Gly Met Ala Gly Asp Trp Lys Thr Thr Phe Thr Val Ala Gln Asn 
225                 230                 235                 240 


Glu Arg Phe Asp Ala Asp Tyr Ala Lys Lys Met Ala Gly Cys Ser Leu 
                245                 250                 255     


Ser Phe Arg Ser Glu Leu 
            260         


<210>  149
<211>  837
<212>  PRT
<213>  Homo sapiens

<400>  149

Met Ala Ser Lys Arg Lys Ser Thr Thr Pro Cys Met Val Arg Thr Ser 
1               5                   10                  15      


Gln Val Val Glu Gln Asp Val Pro Glu Glu Val Asp Arg Ala Lys Glu 
            20                  25                  30          


Lys Gly Ile Gly Thr Pro Gln Pro Asp Val Ala Lys Asp Ser Trp Ala 
        35                  40                  45              


Ala Glu Leu Glu Asn Ser Ser Lys Glu Asn Glu Val Ile Glu Val Lys 
    50                  55                  60                  


Ser Met Gly Glu Ser Gln Ser Lys Lys Leu Gln Gly Gly Tyr Glu Cys 
65                  70                  75                  80  


Lys Tyr Cys Pro Tyr Ser Thr Gln Asn Leu Asn Glu Phe Thr Glu His 
                85                  90                  95      


Val Asp Met Gln His Pro Asn Val Ile Leu Asn Pro Leu Tyr Val Cys 
            100                 105                 110         


Ala Glu Cys Asn Phe Thr Thr Lys Lys Tyr Asp Ser Leu Ser Asp His 
        115                 120                 125             


Asn Ser Lys Phe His Pro Gly Glu Ala Asn Phe Lys Leu Lys Leu Ile 
    130                 135                 140                 


Lys Arg Asn Asn Gln Thr Val Leu Glu Gln Ser Ile Glu Thr Thr Asn 
145                 150                 155                 160 


His Val Val Ser Ile Thr Thr Ser Gly Pro Gly Thr Gly Asp Ser Asp 
                165                 170                 175     


Ser Gly Ile Ser Val Ser Lys Thr Pro Ile Met Lys Pro Gly Lys Pro 
            180                 185                 190         


Lys Ala Asp Ala Lys Lys Val Pro Lys Lys Pro Glu Glu Ile Thr Pro 
        195                 200                 205             


Glu Asn His Val Glu Gly Thr Ala Arg Leu Val Thr Asp Thr Ala Glu 
    210                 215                 220                 


Ile Leu Ser Arg Leu Gly Gly Val Glu Leu Leu Gln Asp Thr Leu Gly 
225                 230                 235                 240 


His Val Met Pro Ser Val Gln Leu Pro Pro Asn Ile Asn Leu Val Pro 
                245                 250                 255     


Lys Val Pro Val Pro Leu Asn Thr Thr Lys Tyr Asn Ser Ala Leu Asp 
            260                 265                 270         


Thr Asn Ala Thr Met Ile Asn Ser Phe Asn Lys Phe Pro Tyr Pro Thr 
        275                 280                 285             


Gln Ala Glu Leu Ser Trp Leu Thr Ala Ala Ser Lys His Pro Glu Glu 
    290                 295                 300                 


His Ile Arg Ile Trp Phe Ala Thr Gln Arg Leu Lys His Gly Ile Ser 
305                 310                 315                 320 


Trp Ser Pro Glu Glu Val Glu Glu Ala Arg Lys Lys Met Phe Asn Gly 
                325                 330                 335     


Thr Ile Gln Ser Val Pro Pro Thr Ile Thr Val Leu Pro Ala Gln Leu 
            340                 345                 350         


Ala Pro Thr Lys Val Thr Gln Pro Ile Leu Gln Thr Ala Leu Pro Cys 
        355                 360                 365             


Gln Ile Leu Gly Gln Thr Ser Leu Val Leu Thr Gln Val Thr Ser Gly 
    370                 375                 380                 


Ser Thr Thr Val Ser Cys Ser Pro Ile Thr Leu Ala Val Ala Gly Val 
385                 390                 395                 400 


Thr Asn His Gly Gln Lys Arg Pro Leu Val Thr Pro Gln Ala Ala Pro 
                405                 410                 415     


Glu Pro Lys Arg Pro His Ile Ala Gln Val Pro Glu Pro Pro Pro Lys 
            420                 425                 430         


Val Ala Asn Pro Pro Leu Thr Pro Ala Ser Asp Arg Lys Lys Thr Lys 
        435                 440                 445             


Glu Gln Ile Ala His Leu Lys Ala Ser Phe Leu Gln Ser Gln Phe Pro 
    450                 455                 460                 


Asp Asp Ala Glu Val Tyr Arg Leu Ile Glu Val Thr Gly Leu Ala Arg 
465                 470                 475                 480 


Ser Glu Ile Lys Lys Trp Phe Ser Asp His Arg Tyr Arg Cys Gln Arg 
                485                 490                 495     


Gly Ile Val His Ile Thr Ser Glu Ser Leu Ala Lys Asp Gln Leu Ala 
            500                 505                 510         


Ile Ala Ala Ser Arg His Gly Arg Thr Tyr His Ala Tyr Pro Asp Phe 
        515                 520                 525             


Ala Pro Gln Lys Phe Lys Glu Lys Thr Gln Gly Gln Val Lys Ile Leu 
    530                 535                 540                 


Glu Asp Ser Phe Leu Lys Ser Ser Phe Pro Thr Gln Ala Glu Leu Asp 
545                 550                 555                 560 


Arg Leu Arg Val Glu Thr Lys Leu Ser Arg Arg Glu Ile Asp Ser Trp 
                565                 570                 575     


Phe Ser Glu Arg Arg Lys Leu Arg Asp Ser Met Glu Gln Ala Val Leu 
            580                 585                 590         


Asp Ser Met Gly Ser Gly Lys Lys Gly Gln Asp Val Gly Ala Pro Asn 
        595                 600                 605             


Gly Ala Leu Ser Arg Leu Asp Gln Leu Ser Gly Ala Gln Leu Thr Ser 
    610                 615                 620                 


Ser Leu Pro Ser Pro Ser Pro Ala Ile Ala Lys Ser Gln Glu Gln Val 
625                 630                 635                 640 


His Leu Leu Arg Ser Thr Phe Ala Arg Thr Gln Trp Pro Thr Pro Gln 
                645                 650                 655     


Glu Tyr Asp Gln Leu Ala Ala Lys Thr Gly Leu Val Arg Thr Glu Ile 
            660                 665                 670         


Val Arg Trp Phe Lys Glu Asn Arg Cys Leu Leu Lys Thr Gly Thr Val 
        675                 680                 685             


Lys Trp Met Glu Gln Tyr Gln His Gln Pro Met Ala Asp Asp His Gly 
    690                 695                 700                 


Tyr Asp Ala Val Ala Arg Lys Ala Thr Lys Pro Met Ala Glu Ser Pro 
705                 710                 715                 720 


Lys Asn Gly Gly Asp Val Val Pro Gln Tyr Tyr Lys Asp Pro Lys Lys 
                725                 730                 735     


Leu Cys Glu Glu Asp Leu Glu Lys Leu Val Thr Arg Val Lys Val Gly 
            740                 745                 750         


Ser Glu Pro Ala Lys Asp Cys Leu Pro Ala Lys Pro Ser Glu Ala Thr 
        755                 760                 765             


Ser Asp Arg Ser Glu Gly Ser Ser Arg Asp Gly Gln Gly Ser Asp Glu 
    770                 775                 780                 


Asn Glu Glu Ser Ser Val Val Asp Tyr Val Glu Val Thr Val Gly Glu 
785                 790                 795                 800 


Glu Asp Ala Ile Ser Asp Arg Ser Asp Ser Trp Ser Gln Ala Ala Ala 
                805                 810                 815     


Glu Gly Val Ser Glu Leu Ala Glu Ser Asp Ser Asp Cys Val Pro Ala 
            820                 825                 830         


Glu Ala Gly Gln Ala 
        835         


<210>  150
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  150

Met Ala Ser Lys Arg Lys Ser Thr Thr Pro Cys Met Val Arg Thr Ser 
1               5                   10                  15      


Gln Val Val Glu Gln Asp Val Pro Glu Glu Val Asp Arg Ala Lys Glu 
            20                  25                  30          


Lys Gly Ile Gly Thr Pro Gln Pro Asp Val Ala Lys Asp Ser Trp Ala 
        35                  40                  45              


Ala Glu Leu Glu Asn Ser Ser Lys Glu Asn Glu Val Ile Glu Val Lys 
    50                  55                  60                  


Ser Met Gly Glu Ser Gln Ser Lys Lys Leu Gln Gly Gly Tyr Glu Cys 
65                  70                  75                  80  


Lys Tyr Cys Pro Tyr Ser Thr Gln Asn Leu Asn Glu Phe Thr Glu His 
                85                  90                  95      


Val Asp Met Gln His Pro Asn Val Ile Leu Asn Pro Leu Tyr Val Cys 
            100                 105                 110         


Ala Glu Cys Asn Phe Thr Thr Lys Lys Tyr Asp Ser Leu Ser Asp His 
        115                 120                 125             


Asn Ser Lys Phe His Pro Gly Glu Ala Asn Phe Lys Leu Lys Leu Ile 
    130                 135                 140                 


Lys Arg Asn Asn Gln Thr Val Leu Glu Gln Ser Ile Glu Thr Thr Asn 
145                 150                 155                 160 


His Val Val Ser Ile Thr 
                165     


<210>  151
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  151

Met Trp Thr Phe Leu Gly Ile Ala Thr Phe Thr Tyr Phe Tyr Lys Lys 
1               5                   10                  15      


Phe Gly Asp Phe Ile Thr Leu Ala Asn Arg Glu Val Leu Leu Cys Val 
            20                  25                  30          


Leu Val Phe Leu Ser Leu Gly Leu Val Leu Ser Tyr Arg Cys Arg His 
        35                  40                  45              


Arg Asn Gly Gly Leu Leu Gly Arg Gln Gln Ser Gly Ser Gln Phe Ala 
    50                  55                  60                  


Leu Phe Ser Asp Ile Leu Ser Gly Leu Pro Phe Ile Gly Phe Phe Trp 
65                  70                  75                  80  


Ala Lys Ser Pro Pro Glu Ser Glu Asn Lys Glu Gln Leu Glu Ala Arg 
                85                  90                  95      


Arg Arg Arg Lys Gly Thr Asn Ile Ser Glu Thr Ser Leu Ile Gly Thr 
            100                 105                 110         


Ala Ala Cys Thr Ser Thr Ser Ser Gln Asn Asp Pro Glu Val Ile Ile 
        115                 120                 125             


Val Gly Ala Gly Val Leu Gly Ser Ala Leu Ala Ala Val Leu Ser Arg 
    130                 135                 140                 


Asp Gly Arg Lys Val Thr Val Ile Glu Arg Asp Leu Lys Glu Pro Asp 
145                 150                 155                 160 


Arg Ile Val Gly Glu Phe Leu Gln Pro Gly Gly Tyr His Val Leu Lys 
                165                 170                 175     


Asp Leu Gly Leu Gly Asp Thr Val Glu Gly Leu Asp Ala Gln Val Val 
            180                 185                 190         


Asn Gly Tyr Met Ile His Asp Gln Glu Ser Lys Ser Glu Val Gln Ile 
        195                 200                 205             


Pro Tyr Pro Leu Ser Glu Asn Asn Gln Val Gln Ser Gly Arg Ala Phe 
    210                 215                 220                 


His His Gly Arg Phe Ile Met Ser Leu Arg Lys Ala Ala Met Ala Glu 
225                 230                 235                 240 


Pro Asn Ala Lys Phe Ile Glu Gly Val Val Leu Gln Leu Leu Glu Glu 
                245                 250                 255     


Asp Asp Val Val Met Gly Val Gln Tyr Lys Asp Lys Glu Thr Gly Asp 
            260                 265                 270         


Ile Lys Glu Leu His Ala Pro Leu Thr Val Val Ala Asp Gly Leu Phe 
        275                 280                 285             


Ser Lys Phe Arg Lys Ser Leu Val Ser Asn Lys Val Ser Val Ser Ser 
    290                 295                 300                 


His Phe Val Gly Phe Leu Met Lys Asn Ala Pro Gln Phe Lys Ala Asn 
305                 310                 315                 320 


His Ala Glu Leu Ile Leu Ala Asn Pro Ser Pro Val Leu Ile Tyr Gln 
                325                 330                 335     


Ile Ser Ser Ser Glu Thr Arg Val Leu Val Asp Ile Arg Gly Glu Met 
            340                 345                 350         


Pro Arg Asn Leu Arg Glu Tyr Met Val Glu Lys Ile Tyr Pro Gln Ile 
        355                 360                 365             


Pro Asp His Leu Lys Glu Pro Phe Leu Glu Ala Thr Asp Asn Ser His 
    370                 375                 380                 


Leu Arg Ser Met Pro Ala Ser Phe Leu Pro Pro Ser Ser Val Lys Lys 
385                 390                 395                 400 


Arg Gly Val Leu Leu Leu Gly Asp Ala Tyr Asn Met Arg His Pro Leu 
                405                 410                 415     


Thr Gly Gly Gly Met Thr Val Ala Phe Lys Asp Ile Lys Leu Trp Arg 
            420                 425                 430         


Lys Leu Leu Lys Gly Ile Pro Asp Leu Tyr Asp Asp Ala Ala Ile Phe 
        435                 440                 445             


Glu Ala Lys Lys Ser Phe Tyr Trp Ala Arg Lys Thr Ser His Ser Phe 
    450                 455                 460                 


Val Val Asn Ile Leu Ala Gln Ala Leu Tyr Glu Leu Phe Ser Ala Thr 
465                 470                 475                 480 


Asp Asp Ser Leu His Gln Leu Arg Lys Ala Cys Phe Leu Tyr Phe Lys 
                485                 490                 495     


Leu Gly Gly Glu Cys Val Ala Gly Pro Val Gly Leu Leu Ser Val Leu 
            500                 505                 510         


Ser Pro Asn Pro Leu Val Leu Ile Gly His Phe Phe Ala Val Ala Ile 
        515                 520                 525             


Tyr Ala Val Tyr Phe Cys Phe Lys Ser Glu Pro Trp Ile Thr Lys Pro 
    530                 535                 540                 


Arg Ala Leu Leu Ser Ser Gly Ala Val Leu Tyr Lys Ala Cys Ser Val 
545                 550                 555                 560 


Ile Phe Pro Leu Ile Tyr Ser Glu Met Lys Tyr Met Val His 
                565                 570                 


<210>  152
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  152

Met Leu Glu Phe His Phe Glu Gly Glu Glu Gln Pro Leu Ser Met Met 
1               5                   10                  15      


Lys Lys Phe Leu Lys Ser Ser Trp Val Arg Ile Gly Phe Val Pro Glu 
            20                  25                  30          


Glu Glu Arg Asn Val Leu Arg Arg Arg Lys Gly Thr Asn Ile Ser Glu 
        35                  40                  45              


Thr Ser Leu Ile Gly Thr Ala Ala Cys Thr Ser Thr Ser Ser Gln Asn 
    50                  55                  60                  


Asp Pro Glu Val Ile Ile Val Gly Ala Gly Val Leu Gly Ser Ala Leu 
65                  70                  75                  80  


Ala Ala Val Leu Ser Arg Asp Gly Arg Lys Val Thr Val Ile Glu Arg 
                85                  90                  95      


Asp Leu Lys Glu Pro Asp Arg Ile Val Gly Glu Phe Leu Gln Pro Gly 
            100                 105                 110         


Gly Tyr His Val Leu Lys Asp Leu Gly Leu Gly Asp Thr Val Glu Gly 
        115                 120                 125             


Leu Asp Ala Gln Val Val Asn Gly Tyr Met Ile His Asp Gln Glu Ser 
    130                 135                 140                 


Lys Ser Glu Val Gln Ile Pro Tyr Pro Leu Ser Glu Asn Asn Gln Val 
145                 150                 155                 160 


Gln Ser Gly Arg Ala Phe His His Gly Arg Phe Ile Met Ser Leu Arg 
                165                 170                 175     


Lys Ala Ala Met Ala Glu Pro Lys 
            180                 


<210>  153
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  153

Met Leu Arg Arg Lys Gly Thr Asn Ile Ser Glu Thr Ser Leu Ile Gly 
1               5                   10                  15      


Thr Ala Ala Cys Thr Ser Thr Ser Ser Gln Asn Asp Pro Glu Val Ile 
            20                  25                  30          


Ile Val Gly Ala Gly Val Leu Gly Ser Ala Leu Ala Ala Val Leu Ser 
        35                  40                  45              


Arg Asp Gly Arg Lys Val Thr Val Ile Glu Arg Asp Leu Lys Glu Pro 
    50                  55                  60                  


Asp Arg Ile Val Gly Glu Phe Leu Gln Pro Gly Gly Tyr His Val Leu 
65                  70                  75                  80  


Lys Asp Leu Gly Leu Gly Asp Thr Val Glu Gly Leu Asp Ala Gln Val 
                85                  90                  95      


Val Asn Gly Tyr Met Ile His Asp Gln Glu Ser Lys Ser Glu Val Gln 
            100                 105                 110         


Ile Pro Tyr Pro Leu Ser Glu Asn Asn Gln Val Gln Ser Gly Arg Ala 
        115                 120                 125             


Phe His His Gly Arg Phe Ile Met Ser Leu Arg Lys Ala Ala Met Ala 
    130                 135                 140                 


Glu Pro Asn Ala Lys Phe Ile Glu Gly Val Val Leu Gln Leu Leu Glu 
145                 150                 155                 160 


Glu Asp Asp Val Val Met Gly Val Gln Tyr Lys Asp Lys Glu Thr Gly 
                165                 170                 175     


Asp Ile Lys Glu Leu His Ala Pro Leu Thr Val Val Ala Asp Gly Leu 
            180                 185                 190         


Phe Ser Lys Phe Arg Lys Ser Leu Val Ser Asn Lys Val Ser Val Ser 
        195                 200                 205             


Ser His Phe Val Gly Phe Leu Met Lys Asn Ala Pro Gln Phe Lys Ala 
    210                 215                 220                 


Asn His Ala Glu Leu Ile Leu Ala Asn Pro Ser Pro Val Leu Ile Tyr 
225                 230                 235                 240 


Gln Ile Ser Ser Ser Glu Thr Arg Val Leu Val Asp Ile Arg Gly Glu 
                245                 250                 255     


Met Pro Arg Asn Leu Arg Glu Tyr Met Val Glu Lys Ile Tyr Pro Gln 
            260                 265                 270         


Ile Pro Asp His Leu Lys Glu Pro Phe Leu Glu Ala Thr Asp Asn Ser 
        275                 280                 285             


His Leu Arg Ser Met Pro Ala Ser Phe Leu Pro Pro Ser Ser Val Lys 
    290                 295                 300                 


Lys Arg Gly Val Leu Leu Leu Gly Asp Ala Tyr Asn Met Arg His Pro 
305                 310                 315                 320 


Leu Thr Gly Gly Gly Met Thr Val Ala Phe Lys Asp Ile Lys Leu Trp 
                325                 330                 335     


Arg Lys Leu Leu Lys Gly Ile Pro Asp Leu Tyr Asp Asp Ala Ala Ile 
            340                 345                 350         


Phe Glu Ala Lys Lys Ser Phe Tyr Trp Ala Arg Lys Thr Ser His Ser 
        355                 360                 365             


Phe Val Val Asn Ile Leu Ala Gln Ala Leu Tyr Glu Leu Phe Ser Ala 
    370                 375                 380                 


Thr Asp Asp Ser Leu His Gln Leu Arg Lys Ala Cys Phe Leu Tyr Phe 
385                 390                 395                 400 


Lys Leu Gly Gly Glu Cys Val Ala Gly Pro Val Gly Leu Leu Ser Val 
                405                 410                 415     


Leu Ser Pro Asn Pro Leu Val Leu Ile Gly His Phe Phe Ala Val Ala 
            420                 425                 430         


Ile Tyr Ala Val Tyr Phe Cys Phe Lys Ser Glu Pro Trp Ile Thr Lys 
        435                 440                 445             


Pro Arg Ala Leu Leu Ser Ser Gly Ala Val Leu Tyr Lys Ala Cys Ser 
    450                 455                 460                 


Val Ile Phe Pro Leu Ile Tyr Ser Glu Met Lys Tyr Met Val His 
465                 470                 475                 


<210>  154
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  154

Arg Gly Glu Met Pro Arg Asn Leu Arg Glu Tyr Met Val Glu Lys Ile 
1               5                   10                  15      


Tyr Pro Gln Ile Pro Asp His Leu Lys Glu Pro Phe Leu Glu Ala Thr 
            20                  25                  30          


Asp Asn Ser His Leu Arg Ser Met Pro Ala Ser Phe Leu Pro Pro Ser 
        35                  40                  45              


Ser Val Lys Lys Arg Gly Val Leu Leu Leu Gly Asp Ala Tyr Asn Met 
    50                  55                  60                  


Arg His Pro Leu Thr Gly Gly Gly Met Thr Val Ala Phe Lys Asp Ile 
65                  70                  75                  80  


Lys Leu Trp Arg Lys Leu Leu Lys Gly Ile Pro Asp Leu Tyr Asp Asp 
                85                  90                  95      


Ala Ala Ile Phe Glu Ala Lys Lys Ser Phe Tyr Trp Ala Arg Lys Thr 
            100                 105                 110         


Ser His Ser Phe Val Val Asn Ile Leu Ala Gln Ala Leu Tyr Glu Leu 
        115                 120                 125             


Phe Ser Ala Thr Asp Asp Ser Leu His Gln Leu Arg Lys Ala Cys Phe 
    130                 135                 140                 


Leu Tyr Phe Lys Leu Gly Gly Glu Cys Val Ala Gly Pro Val Gly Leu 
145                 150                 155                 160 


Leu Ser Val 
            


<210>  155
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  155

Met Gln Ala Ala Val Ala Val Ser Val Pro Phe Leu Leu Leu Cys Val 
1               5                   10                  15      


Leu Gly Thr Cys Pro Pro Ala Arg Cys Gly Gln Ala Gly Asp Ala Ser 
            20                  25                  30          


Leu Met Glu Leu Glu Lys Arg Lys Glu Asn Arg Phe Val Glu Arg Gln 
        35                  40                  45              


Ser Ile Val Pro Leu Arg Leu Ile Tyr Arg Ser Gly Gly Glu Asp Glu 
    50                  55                  60                  


Ser Arg His Asp Ala Leu Asp Thr Arg Val Arg Gly Asp Leu Gly Gly 
65                  70                  75                  80  


Pro Gln Leu Thr His Val Asp Gln Ala Ser Phe Gln Val Asp Ala Phe 
                85                  90                  95      


Gly Thr Ser Phe Ile Leu Asp Val Val Leu Asn His Asp Leu Leu Ser 
            100                 105                 110         


Ser Glu Tyr Ile Glu Arg His Ile Glu His Gly Gly Lys Thr Val Glu 
        115                 120                 125             


Val Lys Gly Gly Glu His Cys Tyr Tyr Gln Gly His Ile Arg Gly Asn 
    130                 135                 140                 


Pro Asp Ser Phe Val Ala Leu Ser Thr Cys His Gly Leu His Gly Met 
145                 150                 155                 160 


Phe Tyr Asp Gly Asn His Thr Tyr Leu Ile Glu Pro Glu Glu Asn Asp 
                165                 170                 175     


Thr Thr Gln Glu Asp Phe His Phe His Ser Val Tyr Lys Ser Arg Leu 
            180                 185                 190         


Phe Glu Phe Ser Leu Asp Asp Leu Pro Ser Glu Phe Gln Gln Val Asn 
        195                 200                 205             


Ile Thr Pro Ser Lys Phe Ile Leu Lys Pro Arg Pro Lys Arg Ser Lys 
    210                 215                 220                 


Arg Gln Leu Arg Arg Tyr Pro Arg Asn Val Glu Glu Glu Thr Lys Tyr 
225                 230                 235                 240 


Ile Glu Leu Met Ile Val Asn Asp His Leu Met Phe Lys Lys His Arg 
                245                 250                 255     


Leu Ser Val Val His Thr Asn Thr Tyr Ala Lys Ser Val Val Asn Met 
            260                 265                 270         


Ala Asp Leu Ile Tyr Lys Asp Gln Leu Lys Thr Arg Ile Val Leu Val 
        275                 280                 285             


Ala Met Glu Thr Trp Ala Thr Asp Asn Lys Phe Ala Ile Ser Glu Asn 
    290                 295                 300                 


Pro Leu Ile Thr Leu Arg Glu Phe Met Lys Tyr Arg Arg Asp Phe Ile 
305                 310                 315                 320 


Lys Glu Lys Ser Asp Ala Val His Leu Phe Ser Gly Ser Gln Phe Glu 
                325                 330                 335     


Ser Ser Arg Ser Gly Ala Ala Tyr Ile Gly Gly Ile Cys Ser Leu Leu 
            340                 345                 350         


Lys Gly Gly Gly Val Asn Glu Phe Gly Lys Thr Asp Leu Met Ala Val 
        355                 360                 365             


Thr Leu Ala Gln Ser Leu Ala His Asn Ile Gly Ile Ile Ser Asp Lys 
    370                 375                 380                 


Arg Lys Leu Ala Ser Gly Glu Cys Lys Cys Glu Asp Thr Trp Ser Gly 
385                 390                 395                 400 


Cys Ile Met Gly Asp Thr Gly Tyr Tyr Leu Pro Lys Lys Phe Thr Gln 
                405                 410                 415     


Cys Asn Ile Glu Glu Tyr His Asp Phe Leu Asn Ser Gly Gly Gly Ala 
            420                 425                 430         


Cys Leu Phe Asn Lys Pro Ser Lys Leu Leu Asp Pro Pro Glu Cys Gly 
        435                 440                 445             


Asn Gly Phe Ile Glu Thr Gly Glu Glu Cys Asp Cys Gly Thr Pro Ala 
    450                 455                 460                 


Glu Cys Val Leu Glu Gly Ala Glu Cys Cys Lys Lys Cys Thr Leu Thr 
465                 470                 475                 480 


Gln Asp Ser Gln Cys Ser Asp Gly Leu Cys Cys Lys Lys Cys Lys Phe 
                485                 490                 495     


Gln Pro Met Gly Thr Val Cys Arg Glu Ala Val Asn Asp Cys Asp Ile 
            500                 505                 510         


Arg Glu Thr Cys Ser Gly Asn Ser Ser Gln Cys Ala Pro Asn Ile His 
        515                 520                 525             


Lys Met Asp Gly Tyr Ser Cys Asp Gly Val Gln Gly Ile Cys Phe Gly 
    530                 535                 540                 


Gly Arg Cys Lys Thr Arg Asp Arg Gln Cys Lys Tyr Ile Trp Gly Gln 
545                 550                 555                 560 


Lys Val Thr Ala Ser Asp Lys Tyr Cys Tyr Glu Lys Leu Asn Ile Glu 
                565                 570                 575     


Gly Thr Glu Lys Gly Asn Cys Gly Lys Asp Lys Asp Thr Trp Ile Gln 
            580                 585                 590         


Cys Asn Lys Arg Asp Val Leu Cys Gly Tyr Leu Leu Cys Thr Asn Ile 
        595                 600                 605             


Gly Asn Ile Pro Arg Leu Gly Glu Leu Asp Gly Glu Ile Thr Ser Thr 
    610                 615                 620                 


Leu Val Val Gln Gln Gly Arg Thr Leu Asn Cys Ser Gly Gly His Val 
625                 630                 635                 640 


Lys Leu Glu Glu Asp Val Asp Leu Gly Tyr Val Glu Asp Gly Thr Pro 
                645                 650                 655     


Cys Gly Pro Gln Met Met Cys Leu Glu His Arg Cys Leu Pro Val Ala 
            660                 665                 670         


Ser Phe Asn Phe Ser Thr Cys Leu Ser Ser Lys Glu Gly Thr Ile Cys 
        675                 680                 685             


Ser Gly Asn Gly Val Cys Ser Asn Glu Leu Lys Cys Val Cys Asn Arg 
    690                 695                 700                 


His Trp Ile Gly Ser Asp Cys Asn Thr Tyr Phe Pro His Asn Asp Asp 
705                 710                 715                 720 


Ala Lys Thr Gly Ile Thr Leu Ser Gly Asn Gly Val Ala Gly Thr Asn 
                725                 730                 735     


Ile Ile Ile Gly Ile Ile Ala Gly Thr Ile Leu Val Leu Ala Leu Ile 
            740                 745                 750         


Leu Gly Ile Thr Ala Trp Gly Tyr Lys Asn Tyr Arg Glu Gln Arg Gln 
        755                 760                 765             


Leu Pro Gln Gly Asp Tyr Val Lys Lys Pro Gly Asp Gly Asp Ser Phe 
    770                 775                 780                 


Tyr Ser Asp Ile Pro Pro Gly Val Ser Thr Asn Ser Ala Ser Ser Ser 
785                 790                 795                 800 


Lys Lys Arg Ser Asn Gly Leu Ser His Ser Trp Ser Glu Arg Ile Pro 
                805                 810                 815     


Asp Thr Lys His Ile Ser Asp Ile Cys Glu Asn Gly Arg Pro Arg Ser 
            820                 825                 830         


Asn Ser Trp Gln Gly Asn Leu Gly Gly Asn Lys Lys Lys Ile Arg Gly 
        835                 840                 845             


Lys Arg Phe Arg Pro Arg Ser Asn Ser Thr Glu Thr Leu Ser Pro Ala 
    850                 855                 860                 


Lys Ser Pro Ser Ser Ser Thr Gly Ser Ile Ala Ser Ser Arg Lys Tyr 
865                 870                 875                 880 


Pro Tyr Pro Met Pro Pro Leu Pro Asp Glu Asp Lys Lys Val Asn Arg 
                885                 890                 895     


Gln Ser Ala Arg Leu Trp Glu Thr Ser Ile 
            900                 905     


<210>  156
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  156

Met Gln Ala Ala Val Ala Val Ser Val Pro Phe Leu Leu Leu Cys Val 
1               5                   10                  15      


Leu Gly Thr Cys Pro Pro Ala Arg Cys Gly Gln Ala Gly Asp Ala Ser 
            20                  25                  30          


Leu Met Glu Leu Glu Lys Arg Lys Glu Asn Arg Phe Val Glu Arg Gln 
        35                  40                  45              


Ser Ile Val Pro Leu Arg Leu Ile Tyr Arg Ser Gly Gly Glu Asp Glu 
    50                  55                  60                  


Ser Arg His Asp Ala Leu Asp Thr Arg Val Arg Gly Asp Leu Gly Gly 
65                  70                  75                  80  


Pro Gln Ile Gln Met Phe Leu Lys Ser Glu Ser Gln Lys Thr Ile Tyr 
                85                  90                  95      


Gln Ile Gln Leu Thr His Val Asp Gln Ala Ser Phe Gln Val Asp Ala 
            100                 105                 110         


Phe Gly Thr Ser Phe Ile Leu Asp Val Val Leu Asn His Asp Leu Leu 
        115                 120                 125             


Ser Ser Glu Tyr Ile Glu Arg His Ile Glu His Gly Gly Lys Thr Val 
    130                 135                 140                 


Glu Val Lys Gly Gly Glu His Cys Tyr Tyr Gln Gly His Ile Arg Gly 
145                 150                 155                 160 


Asn Pro Asp Ser Phe Val Ala Leu Ser Thr Cys His Gly Leu His Gly 
                165                 170                 175     


Met Phe Tyr Asp Gly Asn His Thr Tyr Leu Ile Glu Pro Glu Glu Asn 
            180                 185                 190         


Asp Thr Thr Gln 
        195     


<210>  157
<211>  859
<212>  PRT
<213>  Homo sapiens

<400>  157

Met Gln Ala Ala Val Ala Val Ser Val Pro Phe Leu Leu Leu Cys Val 
1               5                   10                  15      


Leu Gly Thr Cys Pro Pro Ala Arg Cys Gly Gln Ala Gly Asp Ala Ser 
            20                  25                  30          


Leu Met Glu Leu Glu Lys Arg Lys Glu Asn Arg Phe Val Glu Arg Gln 
        35                  40                  45              


Ser Ile Val Pro Leu Arg Leu Ile Tyr Arg Ser Gly Gly Glu Asp Glu 
    50                  55                  60                  


Ser Arg His Asp Ala Leu Asp Thr Arg Val Arg Gly Asp Leu Gly Gly 
65                  70                  75                  80  


Pro Gln Leu Thr His Val Asp Gln Ala Ser Phe Gln Val Asp Ala Phe 
                85                  90                  95      


Gly Thr Ser Phe Ile Leu Asp Val Val Leu Asn His Asp Leu Leu Ser 
            100                 105                 110         


Ser Glu Tyr Ile Glu Arg His Ile Glu His Gly Gly Lys Thr Val Glu 
        115                 120                 125             


Val Lys Gly Gly Glu His Cys Tyr Tyr Gln Gly His Ile Arg Gly Asn 
    130                 135                 140                 


Pro Asp Ser Phe Val Ala Leu Ser Thr Cys His Gly Leu His Gly Met 
145                 150                 155                 160 


Phe Tyr Asp Gly Asn His Thr Tyr Leu Ile Glu Pro Glu Glu Asn Asp 
                165                 170                 175     


Thr Thr Gln Glu Asp Phe His Phe His Ser Val Tyr Lys Ser Arg Leu 
            180                 185                 190         


Phe Glu Phe Ser Leu Asp Asp Leu Pro Ser Glu Phe Gln Gln Val Asn 
        195                 200                 205             


Ile Thr Pro Ser Lys Phe Ile Leu Lys Pro Arg Pro Lys Arg Ser Lys 
    210                 215                 220                 


Arg Gln Leu Arg Arg Tyr Pro Arg Asn Val Glu Glu Glu Thr Lys Tyr 
225                 230                 235                 240 


Ile Glu Leu Met Ile Val Asn Asp His Leu Met Phe Lys Lys His Arg 
                245                 250                 255     


Leu Ser Val Val His Thr Asn Thr Tyr Ala Lys Ser Val Val Asn Met 
            260                 265                 270         


Ala Asp Leu Ile Tyr Lys Asp Gln Leu Lys Thr Arg Ile Val Leu Val 
        275                 280                 285             


Ala Met Glu Thr Trp Ala Thr Asp Asn Lys Phe Ala Ile Ser Glu Asn 
    290                 295                 300                 


Pro Leu Ile Thr Leu Arg Glu Phe Met Lys Tyr Arg Arg Asp Phe Ile 
305                 310                 315                 320 


Lys Glu Lys Ser Asp Ala Val His Leu Phe Ser Gly Ser Gln Phe Glu 
                325                 330                 335     


Ser Ser Arg Ser Gly Ala Ala Tyr Ile Gly Gly Ile Cys Ser Leu Leu 
            340                 345                 350         


Lys Gly Gly Gly Val Asn Glu Phe Gly Lys Thr Asp Leu Met Ala Val 
        355                 360                 365             


Thr Leu Ala Gln Ser Leu Ala His Asn Ile Gly Ile Ile Ser Asp Lys 
    370                 375                 380                 


Arg Lys Leu Ala Ser Gly Glu Cys Lys Cys Glu Asp Thr Trp Ser Gly 
385                 390                 395                 400 


Cys Ile Met Gly Asp Thr Gly Tyr Tyr Leu Pro Lys Lys Phe Thr Gln 
                405                 410                 415     


Cys Asn Ile Glu Glu Tyr His Asp Phe Leu Asn Ser Gly Gly Gly Ala 
            420                 425                 430         


Cys Leu Phe Asn Lys Pro Ser Lys Leu Leu Asp Pro Pro Glu Cys Gly 
        435                 440                 445             


Asn Gly Phe Ile Glu Thr Gly Glu Glu Cys Asp Cys Gly Thr Pro Ala 
    450                 455                 460                 


Glu Cys Val Leu Glu Gly Ala Glu Cys Cys Lys Lys Cys Thr Leu Thr 
465                 470                 475                 480 


Gln Asp Ser Gln Cys Ser Asp Gly Leu Cys Cys Lys Lys Cys Lys Phe 
                485                 490                 495     


Gln Pro Met Gly Thr Val Cys Arg Glu Ala Val Asn Asp Cys Asp Ile 
            500                 505                 510         


Arg Glu Thr Cys Ser Gly Asn Ser Ser Gln Cys Ala Pro Asn Ile His 
        515                 520                 525             


Lys Met Asp Gly Tyr Ser Cys Asp Gly Val Gln Gly Ile Cys Phe Gly 
    530                 535                 540                 


Gly Arg Cys Lys Thr Arg Asp Arg Gln Cys Lys Tyr Ile Trp Gly Gln 
545                 550                 555                 560 


Lys Val Thr Ala Ser Asp Lys Tyr Cys Tyr Glu Lys Leu Asn Ile Glu 
                565                 570                 575     


Gly Thr Glu Lys Gly Asn Cys Gly Lys Asp Lys Asp Thr Trp Ile Gln 
            580                 585                 590         


Cys Asn Lys Arg Asp Val Leu Cys Gly Tyr Leu Leu Cys Thr Asn Ile 
        595                 600                 605             


Gly Asn Ile Pro Arg Leu Gly Glu Leu Asp Gly Glu Ile Thr Ser Thr 
    610                 615                 620                 


Leu Val Val Gln Gln Gly Arg Thr Leu Asn Cys Ser Gly Gly His Val 
625                 630                 635                 640 


Lys Leu Glu Glu Asp Val Asp Leu Gly Tyr Val Glu Asp Gly Thr Pro 
                645                 650                 655     


Cys Gly Pro Gln Met Met Cys Leu Glu His Arg Cys Leu Pro Val Ala 
            660                 665                 670         


Ser Phe Asn Phe Ser Thr Cys Leu Ser Ser Lys Glu Gly Thr Ile Cys 
        675                 680                 685             


Ser Gly Asn Gly Val Cys Ser Asn Glu Leu Lys Cys Val Cys Asn Arg 
    690                 695                 700                 


His Trp Ile Gly Ser Asp Cys Asn Thr Tyr Phe Pro His Asn Asp Asp 
705                 710                 715                 720 


Ala Lys Thr Gly Ile Thr Leu Ser Gly Asn Gly Val Ala Gly Thr Asn 
                725                 730                 735     


Ile Ile Ile Gly Ile Ile Ala Gly Thr Ile Leu Val Leu Ala Leu Ile 
            740                 745                 750         


Leu Gly Ile Thr Ala Trp Gly Tyr Lys Asn Tyr Arg Glu Gln Arg Gln 
        755                 760                 765             


Leu Pro Gln Gly Asp Tyr Val Lys Lys Pro Gly Asp Gly Asp Ser Phe 
    770                 775                 780                 


Tyr Ser Asp Ile Pro Pro Gly Val Ser Thr Asn Ser Ala Ser Ser Ser 
785                 790                 795                 800 


Lys Lys Arg Ser Asn Gly Leu Ser His Ser Trp Ser Glu Arg Ile Pro 
                805                 810                 815     


Asp Thr Lys His Ile Ser Asp Ile Cys Glu Asn Gly Arg Pro Arg Ser 
            820                 825                 830         


Asn Ser Trp Gln Gly Asn Leu Gly Gly Asn Lys Lys Lys Ile Arg Gly 
        835                 840                 845             


Lys Arg Phe Arg Pro Arg Ser Asn Ser Thr Glu 
    850                 855                 


<210>  158
<211>  899
<212>  PRT
<213>  Homo sapiens

<400>  158

Met Gln Ala Ala Val Ala Val Ser Val Pro Phe Leu Leu Leu Cys Val 
1               5                   10                  15      


Leu Gly Thr Cys Pro Pro Ala Arg Cys Gly Gln Ala Gly Asp Ala Ser 
            20                  25                  30          


Leu Met Glu Leu Glu Lys Arg Lys Glu Asn Arg Phe Val Glu Arg Gln 
        35                  40                  45              


Ser Ile Val Pro Leu Arg Leu Ile Tyr Arg Ser Gly Gly Glu Asp Glu 
    50                  55                  60                  


Ser Arg His Asp Ala Leu Asp Thr Arg Val Arg Gly Asp Leu Gly Gly 
65                  70                  75                  80  


Pro Gln Leu Thr His Val Asp Gln Ala Ser Phe Gln Val Asp Ala Phe 
                85                  90                  95      


Gly Thr Ser Phe Ile Leu Asp Val Val Leu Asn His Asp Leu Leu Ser 
            100                 105                 110         


Ser Glu Tyr Ile Glu Arg His Ile Glu His Gly Gly Lys Thr Val Glu 
        115                 120                 125             


Val Lys Gly Gly Glu His Cys Tyr Tyr Gln Gly His Ile Arg Gly Asn 
    130                 135                 140                 


Pro Asp Ser Phe Val Ala Leu Ser Thr Cys His Gly Leu His Gly Met 
145                 150                 155                 160 


Phe Tyr Asp Gly Asn His Thr Tyr Leu Ile Glu Pro Glu Glu Asn Asp 
                165                 170                 175     


Thr Thr Gln Glu Asp Phe His Phe His Ser Val Tyr Lys Ser Arg Leu 
            180                 185                 190         


Phe Glu Phe Ser Leu Asp Asp Leu Pro Ser Glu Phe Gln Gln Val Asn 
        195                 200                 205             


Ile Thr Pro Ser Lys Phe Ile Leu Lys Pro Arg Pro Lys Arg Ser Lys 
    210                 215                 220                 


Arg Gln Leu Arg Arg Tyr Pro Arg Asn Val Glu Glu Glu Thr Lys Tyr 
225                 230                 235                 240 


Ile Glu Leu Met Ile Val Asn Asp His Leu Met Phe Lys Lys His Arg 
                245                 250                 255     


Leu Ser Val Val His Thr Asn Thr Tyr Ala Lys Ser Val Val Asn Met 
            260                 265                 270         


Ala Asp Leu Ile Tyr Lys Asp Gln Leu Lys Thr Arg Ile Val Leu Val 
        275                 280                 285             


Ala Met Glu Thr Trp Ala Thr Asp Asn Lys Phe Ala Ile Ser Glu Asn 
    290                 295                 300                 


Pro Leu Ile Thr Leu Arg Glu Phe Met Lys Tyr Arg Arg Asp Phe Ile 
305                 310                 315                 320 


Lys Glu Lys Ser Asp Ala Val His Leu Phe Ser Gly Ser Gln Phe Glu 
                325                 330                 335     


Ser Ser Arg Ser Gly Ala Ala Tyr Ile Gly Gly Ile Cys Ser Leu Leu 
            340                 345                 350         


Lys Gly Gly Gly Val Asn Glu Phe Gly Lys Thr Asp Leu Met Ala Val 
        355                 360                 365             


Thr Leu Ala Gln Ser Leu Ala His Asn Ile Gly Ile Ile Ser Asp Lys 
    370                 375                 380                 


Arg Lys Leu Ala Ser Gly Glu Cys Lys Cys Glu Asp Thr Trp Ser Gly 
385                 390                 395                 400 


Cys Ile Met Gly Asp Thr Gly Tyr Tyr Leu Pro Lys Lys Phe Thr Gln 
                405                 410                 415     


Cys Asn Ile Glu Glu Tyr His Asp Phe Leu Asn Ser Gly Gly Gly Ala 
            420                 425                 430         


Cys Leu Phe Asn Lys Pro Ser Lys Leu Leu Asp Pro Pro Glu Cys Gly 
        435                 440                 445             


Asn Gly Phe Ile Glu Thr Gly Glu Glu Cys Asp Cys Gly Thr Pro Ala 
    450                 455                 460                 


Glu Cys Val Leu Glu Gly Ala Glu Cys Cys Lys Lys Cys Thr Leu Thr 
465                 470                 475                 480 


Gln Asp Ser Gln Cys Ser Asp Gly Leu Cys Cys Lys Lys Cys Lys Phe 
                485                 490                 495     


Gln Pro Met Gly Thr Val Cys Arg Glu Ala Val Asn Asp Cys Asp Ile 
            500                 505                 510         


Arg Glu Thr Cys Ser Gly Asn Ser Ser Gln Cys Ala Pro Asn Ile His 
        515                 520                 525             


Lys Met Asp Gly Tyr Ser Cys Asp Gly Val Gln Gly Ile Cys Phe Gly 
    530                 535                 540                 


Gly Arg Cys Lys Thr Arg Asp Arg Gln Cys Lys Tyr Ile Trp Gly Gln 
545                 550                 555                 560 


Lys Val Thr Ala Ser Asp Lys Tyr Cys Tyr Glu Lys Leu Asn Ile Glu 
                565                 570                 575     


Gly Thr Glu Lys Gly Asn Cys Gly Lys Asp Lys Asp Thr Trp Ile Gln 
            580                 585                 590         


Cys Asn Lys Arg Asp Val Leu Cys Gly Tyr Leu Leu Cys Thr Asn Ile 
        595                 600                 605             


Gly Asn Ile Pro Arg Leu Gly Glu Leu Asp Gly Glu Ile Thr Ser Thr 
    610                 615                 620                 


Leu Val Val Gln Gln Gly Arg Thr Leu Asn Cys Ser Gly Gly His Val 
625                 630                 635                 640 


Lys Leu Glu Glu Asp Val Asp Leu Gly Tyr Val Glu Asp Gly Thr Pro 
                645                 650                 655     


Cys Gly Pro Gln Met Met Cys Leu Glu His Arg Cys Leu Pro Val Ala 
            660                 665                 670         


Ser Phe Asn Phe Ser Thr Cys Leu Ser Ser Lys Glu Gly Thr Ile Cys 
        675                 680                 685             


Ser Gly Asn Gly Val Cys Ser Asn Glu Leu Lys Cys Val Cys Asn Arg 
    690                 695                 700                 


His Trp Ile Gly Ser Asp Cys Asn Thr Tyr Phe Pro His Asn Asp Asp 
705                 710                 715                 720 


Ala Lys Thr Gly Ile Thr Leu Ser Gly Asn Gly Val Ala Gly Thr Asn 
                725                 730                 735     


Ile Ile Ile Gly Ile Ile Ala Gly Thr Ile Leu Val Leu Ala Leu Ile 
            740                 745                 750         


Leu Gly Ile Thr Ala Trp Gly Tyr Lys Asn Tyr Arg Glu Gln Arg Ser 
        755                 760                 765             


Asn Gly Leu Ser His Ser Trp Ser Glu Arg Ile Pro Asp Thr Lys His 
    770                 775                 780                 


Ile Ser Asp Ile Cys Glu Asn Gly Arg Pro Arg Ser Asn Ser Trp Gln 
785                 790                 795                 800 


Gly Asn Leu Gly Gly Asn Lys Lys Lys Ile Arg Gly Lys Arg Phe Arg 
                805                 810                 815     


Pro Arg Ser Asn Ser Thr Glu Tyr Leu Asn Pro Trp Phe Lys Arg Asp 
            820                 825                 830         


Tyr Asn Val Ala Lys Trp Val Glu Asp Val Asn Lys Asn Thr Glu Gly 
        835                 840                 845             


Pro Tyr Phe Arg Thr Leu Ser Pro Ala Lys Ser Pro Ser Ser Ser Thr 
    850                 855                 860                 


Gly Ser Ile Ala Ser Ser Arg Lys Tyr Pro Tyr Pro Met Pro Pro Leu 
865                 870                 875                 880 


Pro Asp Glu Asp Lys Lys Val Asn Arg Gln Ser Ala Arg Leu Trp Glu 
                885                 890                 895     


Thr Ser Ile 
            


<210>  159
<211>  804
<212>  PRT
<213>  Homo sapiens

<400>  159

Met Glu Leu Glu Lys Arg Lys Glu Asn Arg Phe Val Glu Arg Gln Ser 
1               5                   10                  15      


Ile Val Pro Leu Arg Leu Ile Tyr Arg Ser Gly Gly Glu Asp Glu Ser 
            20                  25                  30          


Arg His Asp Ala Leu Asp Thr Arg Val Arg Gly Asp Leu Gly Gly Pro 
        35                  40                  45              


Gln Leu Thr His Val Asp Gln Ala Ser Phe Gln Val Asp Ala Phe Gly 
    50                  55                  60                  


Thr Ser Phe Ile Leu Asp Val Val Leu Asn His Asp Leu Leu Ser Ser 
65                  70                  75                  80  


Glu Tyr Ile Glu Arg His Ile Glu His Gly Gly Lys Thr Val Glu Val 
                85                  90                  95      


Lys Gly Gly Glu His Cys Tyr Tyr Gln Gly His Ile Arg Gly Asn Pro 
            100                 105                 110         


Asp Ser Phe Val Ala Leu Ser Thr Cys His Gly Leu His Gly Met Phe 
        115                 120                 125             


Tyr Asp Gly Asn His Thr Tyr Leu Ile Glu Pro Glu Glu Asn Asp Thr 
    130                 135                 140                 


Thr Gln Glu Asp Phe His Phe His Ser Val Tyr Lys Ser Arg Leu Phe 
145                 150                 155                 160 


Glu Phe Ser Leu Asp Asp Leu Pro Ser Glu Phe Gln Gln Val Asn Ile 
                165                 170                 175     


Thr Pro Ser Lys Phe Ile Leu Lys Pro Arg Pro Lys Arg Ser Lys Arg 
            180                 185                 190         


Gln Leu Arg Arg Tyr Pro Arg Asn Val Glu Glu Glu Thr Lys Tyr Ile 
        195                 200                 205             


Glu Leu Met Ile Val Asn Asp His Leu Met Phe Lys Lys His Arg Leu 
    210                 215                 220                 


Ser Val Val His Thr Asn Thr Tyr Ala Lys Ser Val Val Asn Met Ala 
225                 230                 235                 240 


Asp Leu Ile Tyr Lys Asp Gln Leu Lys Thr Arg Ile Val Leu Val Ala 
                245                 250                 255     


Met Glu Thr Trp Ala Thr Asp Asn Lys Phe Ala Ile Ser Glu Asn Pro 
            260                 265                 270         


Leu Ile Thr Leu Arg Glu Phe Met Lys Tyr Arg Arg Asp Phe Ile Lys 
        275                 280                 285             


Glu Lys Ser Asp Ala Val His Leu Phe Ser Gly Ser Gln Phe Glu Ser 
    290                 295                 300                 


Ser Arg Ser Gly Ala Ala Tyr Ile Gly Gly Ile Cys Ser Leu Leu Lys 
305                 310                 315                 320 


Gly Gly Gly Val Asn Glu Phe Gly Lys Thr Asp Leu Met Ala Val Thr 
                325                 330                 335     


Leu Ala Gln Ser Leu Ala His Asn Ile Gly Ile Ile Ser Asp Lys Arg 
            340                 345                 350         


Lys Leu Ala Ser Gly Glu Cys Lys Cys Glu Asp Thr Trp Ser Gly Cys 
        355                 360                 365             


Ile Met Gly Asp Thr Gly Tyr Tyr Leu Pro Lys Lys Phe Thr Gln Cys 
    370                 375                 380                 


Asn Ile Glu Glu Tyr His Asp Phe Leu Asn Ser Gly Gly Gly Ala Cys 
385                 390                 395                 400 


Leu Phe Asn Lys Pro Ser Lys Leu Leu Asp Pro Pro Glu Cys Gly Asn 
                405                 410                 415     


Gly Phe Ile Glu Thr Gly Glu Glu Cys Asp Cys Gly Thr Pro Ala Glu 
            420                 425                 430         


Cys Val Leu Glu Gly Ala Glu Cys Cys Lys Lys Cys Thr Leu Thr Gln 
        435                 440                 445             


Asp Ser Gln Cys Ser Asp Gly Leu Cys Cys Lys Lys Cys Lys Phe Gln 
    450                 455                 460                 


Pro Met Gly Thr Val Cys Arg Glu Ala Val Asn Asp Cys Asp Ile Arg 
465                 470                 475                 480 


Glu Thr Cys Ser Gly Asn Ser Ser Gln Cys Ala Pro Asn Ile His Lys 
                485                 490                 495     


Met Asp Gly Tyr Ser Cys Asp Gly Val Gln Gly Ile Cys Phe Gly Gly 
            500                 505                 510         


Arg Cys Lys Thr Arg Asp Arg Gln Cys Lys Tyr Ile Trp Gly Gln Lys 
        515                 520                 525             


Val Thr Ala Ser Asp Lys Tyr Cys Tyr Glu Lys Leu Asn Ile Glu Gly 
    530                 535                 540                 


Thr Glu Lys Gly Asn Cys Gly Lys Asp Lys Asp Thr Trp Ile Gln Cys 
545                 550                 555                 560 


Asn Lys Arg Asp Val Leu Cys Gly Tyr Leu Leu Cys Thr Asn Ile Gly 
                565                 570                 575     


Asn Ile Pro Arg Leu Gly Glu Leu Asp Gly Glu Ile Thr Ser Thr Leu 
            580                 585                 590         


Val Val Gln Gln Gly Arg Thr Leu Asn Cys Ser Gly Gly His Val Lys 
        595                 600                 605             


Leu Glu Glu Asp Val Asp Leu Gly Tyr Val Glu Asp Gly Thr Pro Cys 
    610                 615                 620                 


Gly Pro Gln Met Met Cys Leu Glu His Arg Cys Leu Pro Val Ala Ser 
625                 630                 635                 640 


Phe Asn Phe Ser Thr Cys Leu Ser Ser Lys Glu Gly Thr Ile Cys Ser 
                645                 650                 655     


Gly Asn Gly Val Cys Ser Asn Glu Leu Lys Cys Val Cys Asn Arg His 
            660                 665                 670         


Trp Ile Gly Ser Asp Cys Asn Thr Tyr Phe Pro His Asn Asp Asp Ala 
        675                 680                 685             


Lys Thr Gly Ile Thr Leu Ser Gly Asn Gly Val Ala Gly Thr Asn Ile 
    690                 695                 700                 


Ile Ile Gly Ile Ile Ala Gly Thr Ile Leu Val Leu Ala Leu Ile Leu 
705                 710                 715                 720 


Gly Ile Thr Ala Trp Gly Tyr Lys Asn Tyr Arg Glu Gln Arg Gln Leu 
                725                 730                 735     


Pro Gln Gly Asp Tyr Val Lys Lys Pro Gly Asp Gly Asp Ser Phe Tyr 
            740                 745                 750         


Ser Asp Ile Pro Pro Gly Val Ser Thr Asn Ser Ala Ser Ser Ser Lys 
        755                 760                 765             


Lys Arg Ser Asn Gly Leu Ser His Ser Trp Ser Glu Arg Ile Pro Asp 
    770                 775                 780                 


Thr Lys His Ile Ser Asp Ile Cys Glu Asn Gly Arg Pro Arg Ser Asn 
785                 790                 795                 800 


Ser Trp Gln Gly 
                


<210>  160
<211>  870
<212>  PRT
<213>  Homo sapiens

<400>  160

Met Gln Ala Ala Val Ala Val Ser Val Pro Phe Leu Leu Leu Cys Val 
1               5                   10                  15      


Leu Gly Thr Cys Pro Pro Ala Arg Cys Gly Gln Ala Gly Asp Ala Ser 
            20                  25                  30          


Leu Met Glu Leu Glu Lys Arg Lys Glu Asn Arg Phe Val Glu Arg Gln 
        35                  40                  45              


Ser Ile Val Pro Leu Arg Leu Ile Tyr Arg Ser Gly Gly Glu Asp Glu 
    50                  55                  60                  


Ser Arg His Asp Ala Leu Asp Thr Arg Val Arg Gly Asp Leu Gly Gly 
65                  70                  75                  80  


Pro Gln Leu Thr His Val Asp Gln Ala Ser Phe Gln Val Asp Ala Phe 
                85                  90                  95      


Gly Thr Ser Phe Ile Leu Asp Val Val Leu Asn His Asp Leu Leu Ser 
            100                 105                 110         


Ser Glu Tyr Ile Glu Arg His Ile Glu His Gly Gly Lys Thr Val Glu 
        115                 120                 125             


Val Lys Gly Gly Glu His Cys Tyr Tyr Gln Gly His Ile Arg Gly Asn 
    130                 135                 140                 


Pro Asp Ser Phe Val Ala Leu Ser Thr Cys His Gly Leu His Gly Met 
145                 150                 155                 160 


Phe Tyr Asp Gly Asn His Thr Tyr Leu Ile Glu Pro Glu Glu Asn Asp 
                165                 170                 175     


Thr Thr Gln Glu Asp Phe His Phe His Ser Val Tyr Lys Ser Arg Leu 
            180                 185                 190         


Phe Glu Phe Ser Leu Asp Asp Leu Pro Ser Glu Phe Gln Gln Val Asn 
        195                 200                 205             


Ile Thr Pro Ser Lys Phe Ile Leu Lys Pro Arg Pro Lys Arg Ser Lys 
    210                 215                 220                 


Arg Gln Leu Arg Arg Tyr Pro Arg Asn Val Glu Glu Glu Thr Lys Tyr 
225                 230                 235                 240 


Ile Glu Leu Met Ile Val Asn Asp His Leu Met Phe Lys Lys His Arg 
                245                 250                 255     


Leu Ser Val Val His Thr Asn Thr Tyr Ala Lys Ser Val Val Asn Met 
            260                 265                 270         


Ala Asp Leu Ile Tyr Lys Asp Gln Leu Lys Thr Arg Ile Val Leu Val 
        275                 280                 285             


Ala Met Glu Thr Trp Ala Thr Asp Asn Lys Phe Ala Ile Ser Glu Asn 
    290                 295                 300                 


Pro Leu Ile Thr Leu Arg Glu Phe Met Lys Tyr Arg Arg Asp Phe Ile 
305                 310                 315                 320 


Lys Glu Lys Ser Asp Ala Val His Leu Phe Ser Gly Ser Gln Phe Glu 
                325                 330                 335     


Ser Ser Arg Ser Gly Ala Ala Tyr Ile Gly Gly Ile Cys Ser Leu Leu 
            340                 345                 350         


Lys Gly Gly Gly Val Asn Glu Phe Gly Lys Thr Asp Leu Met Ala Val 
        355                 360                 365             


Thr Leu Ala Gln Ser Leu Ala His Asn Ile Gly Ile Ile Ser Asp Lys 
    370                 375                 380                 


Arg Lys Leu Ala Ser Gly Glu Cys Lys Cys Glu Asp Thr Trp Ser Gly 
385                 390                 395                 400 


Cys Ile Met Gly Asp Thr Gly Tyr Tyr Leu Pro Lys Lys Phe Thr Gln 
                405                 410                 415     


Cys Asn Ile Glu Glu Tyr His Asp Phe Leu Asn Ser Gly Gly Gly Ala 
            420                 425                 430         


Cys Leu Phe Asn Lys Pro Ser Lys Leu Leu Asp Pro Pro Glu Cys Gly 
        435                 440                 445             


Asn Gly Phe Ile Glu Thr Gly Glu Glu Cys Asp Cys Gly Thr Pro Ala 
    450                 455                 460                 


Glu Cys Val Leu Glu Gly Ala Glu Cys Cys Lys Lys Cys Thr Leu Thr 
465                 470                 475                 480 


Gln Asp Ser Gln Cys Ser Asp Gly Leu Cys Cys Lys Lys Cys Lys Phe 
                485                 490                 495     


Gln Pro Met Gly Thr Val Cys Arg Glu Ala Val Asn Asp Cys Asp Ile 
            500                 505                 510         


Arg Glu Thr Cys Ser Gly Asn Ser Ser Gln Cys Ala Pro Asn Ile His 
        515                 520                 525             


Lys Met Asp Gly Tyr Ser Cys Asp Gly Val Gln Gly Ile Cys Phe Gly 
    530                 535                 540                 


Gly Arg Cys Lys Thr Arg Asp Arg Gln Cys Lys Tyr Ile Trp Gly Gln 
545                 550                 555                 560 


Lys Val Thr Ala Ser Asp Lys Tyr Cys Tyr Glu Lys Leu Asn Ile Glu 
                565                 570                 575     


Gly Thr Glu Lys Gly Asn Cys Gly Lys Asp Lys Asp Thr Trp Ile Gln 
            580                 585                 590         


Cys Asn Lys Arg Asp Val Leu Cys Gly Tyr Leu Leu Cys Thr Asn Ile 
        595                 600                 605             


Gly Asn Ile Pro Arg Leu Gly Glu Leu Asp Gly Glu Ile Thr Ser Thr 
    610                 615                 620                 


Leu Val Val Gln Gln Gly Arg Thr Leu Asn Cys Ser Gly Gly His Val 
625                 630                 635                 640 


Lys Leu Glu Glu Asp Val Asp Leu Gly Tyr Val Glu Asp Gly Thr Pro 
                645                 650                 655     


Cys Gly Pro Gln Met Met Cys Leu Glu His Arg Cys Leu Pro Val Ala 
            660                 665                 670         


Ser Phe Asn Phe Ser Thr Cys Leu Ser Ser Lys Glu Gly Thr Ile Cys 
        675                 680                 685             


Ser Gly Asn Gly Val Cys Ser Asn Glu Leu Lys Cys Val Cys Asn Arg 
    690                 695                 700                 


His Trp Ile Gly Ser Asp Cys Asn Thr Tyr Phe Pro His Asn Asp Asp 
705                 710                 715                 720 


Ala Lys Thr Gly Ile Thr Leu Ser Gly Asn Gly Val Ala Gly Thr Asn 
                725                 730                 735     


Ile Ile Ile Gly Ile Ile Ala Gly Thr Ile Leu Val Leu Ala Leu Ile 
            740                 745                 750         


Leu Gly Ile Thr Ala Trp Gly Tyr Lys Asn Tyr Arg Glu Gln Arg Ser 
        755                 760                 765             


Asn Gly Leu Ser His Ser Trp Ser Glu Arg Ile Pro Asp Thr Lys His 
    770                 775                 780                 


Ile Ser Asp Ile Cys Glu Asn Gly Arg Pro Arg Ser Asn Ser Trp Gln 
785                 790                 795                 800 


Gly Asn Leu Gly Gly Asn Lys Lys Lys Ile Arg Gly Lys Arg Phe Arg 
                805                 810                 815     


Pro Arg Ser Asn Ser Thr Glu Thr Leu Ser Pro Ala Lys Ser Pro Ser 
            820                 825                 830         


Ser Ser Thr Gly Ser Ile Ala Ser Ser Arg Lys Tyr Pro Tyr Pro Met 
        835                 840                 845             


Pro Pro Leu Pro Asp Glu Asp Lys Lys Val Asn Arg Gln Ser Ala Arg 
    850                 855                 860                 


Leu Trp Glu Thr Ser Ile 
865                 870 


<210>  161
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  161

Met Gln Ala Ala Val Ala Val Ser Val Pro Phe Leu Leu Leu Cys Val 
1               5                   10                  15      


Leu Gly Thr Cys Pro Pro Ala Arg Cys Gly Gln Ala Gly Asp Ala Ser 
            20                  25                  30          


Leu Met Glu Leu Glu Lys Arg Lys Glu Asn Arg Phe Val Glu Arg Gln 
        35                  40                  45              


Ser Ile Val Pro Leu Arg Leu Ile Tyr Arg Ser Gly Gly Glu Asp Glu 
    50                  55                  60                  


Ser Arg His Asp Ala Leu Asp Thr Arg Val Arg Gly Asp Leu Gly Gly 
65                  70                  75                  80  


Pro Gln Leu Thr His Val Asp Gln Ala Ser Phe Gln Val Asp Ala Phe 
                85                  90                  95      


Gly Thr Ser Phe Ile Leu Asp Val Val Leu Asn His Asp Leu Leu Ser 
            100                 105                 110         


Ser Glu Tyr Ile Glu Arg His Ile Glu His Gly Gly Lys Thr Val Glu 
        115                 120                 125             


Val Lys Gly Gly Glu His Cys Tyr Tyr Gln Gly His Ile Arg Gly Asn 
    130                 135                 140                 


Pro Asp Ser Phe Val Ala Leu Ser Thr Cys His Gly Leu His Gly Met 
145                 150                 155                 160 


Phe Tyr Asp Gly Asn His Thr Tyr Leu Ile Glu Pro Glu Glu Asn Asp 
                165                 170                 175     


Thr Thr Gln Glu Asp Phe His Phe His Ser Val Tyr Lys Ser Arg Leu 
            180                 185                 190         


Phe Glu Phe Ser Leu Asp Asp Leu Pro Ser Glu Phe Gln Gln Val Asn 
        195                 200                 205             


Ile Thr Pro Ser Lys Phe Ile Leu Lys Pro Arg Pro Lys Arg Ser Lys 
    210                 215                 220                 


Arg Gln Leu Arg Arg Tyr Pro Arg Asn Val Glu Glu Glu Thr Lys Tyr 
225                 230                 235                 240 


Ile Glu Leu Met Ile Val Asn Asp His Leu Met Phe Lys Lys His Arg 
                245                 250                 255     


Leu Ser Val Val His Thr Asn Thr Tyr Ala Lys Ser Val Val Asn Met 
            260                 265                 270         


Ala Asp Leu Ile Tyr Lys Asp Gln Leu Lys Thr Arg Ile Val Leu Val 
        275                 280                 285             


Ala Met Glu Thr Trp Ala Thr Asp Asn Lys Phe Ala Ile Ser Glu Asn 
    290                 295                 300                 


Pro Leu Ile Thr Leu Arg Glu Phe Met Lys Tyr Arg Arg Asp Phe Ile 
305                 310                 315                 320 


Lys Glu Lys Ser Asp Ala Val His Leu Phe Ser Tyr Val Thr Ser Val 
                325                 330                 335     


Met Met Tyr Tyr Phe Phe 
            340         


<210>  162
<211>  264
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  162

Xaa Cys Asn Arg His Trp Ile Gly Ser Asp Cys Asn Thr Tyr Phe Pro 
1               5                   10                  15      


His Asn Asp Asp Ala Lys Thr Gly Ile Thr Leu Ser Gly Asn Gly Val 
            20                  25                  30          


Ala Gly Thr Asn Ile Ile Ile Gly Ile Ile Ala Gly Thr Ile Leu Val 
        35                  40                  45              


Leu Ala Leu Ile Leu Gly Ile Thr Ala Trp Gly Tyr Lys Asn Tyr Arg 
    50                  55                  60                  


Glu Gln Arg Gln Leu Pro Gln Gly Asp Tyr Val Lys Lys Pro Gly Asp 
65                  70                  75                  80  


Gly Asp Ser Phe Tyr Ser Asp Ile Pro Pro Gly Val Ser Thr Asn Ser 
                85                  90                  95      


Ala Ser Ser Ser Lys Lys Arg Ser Ala Phe Leu Ser His Phe Gln Ile 
            100                 105                 110         


Ser Thr Cys Ser Ile Thr His Tyr Ser Ile Ser Gln Asn Ile Ser Leu 
        115                 120                 125             


Phe Cys Ser Arg Ser Asn Gly Leu Ser His Ser Trp Ser Glu Arg Ile 
    130                 135                 140                 


Pro Asp Thr Lys His Ile Ser Asp Ile Cys Glu Asn Gly Arg Pro Arg 
145                 150                 155                 160 


Ser Asn Ser Trp Gln Gly Asn Leu Gly Gly Asn Lys Lys Lys Ile Arg 
                165                 170                 175     


Gly Lys Arg Phe Arg Pro Arg Ser Asn Ser Thr Glu Tyr Leu Asn Pro 
            180                 185                 190         


Trp Phe Lys Arg Asp Tyr Asn Val Ala Lys Trp Val Glu Asp Val Asn 
        195                 200                 205             


Lys Asn Thr Glu Gly Pro Tyr Phe Arg Thr Leu Ser Pro Ala Lys Ser 
    210                 215                 220                 


Pro Ser Ser Ser Thr Gly Ser Ile Ala Ser Ser Arg Lys Tyr Pro Tyr 
225                 230                 235                 240 


Pro Met Pro Pro Leu Pro Asp Glu Asp Lys Lys Val Asn Arg Gln Ser 
                245                 250                 255     


Ala Arg Leu Trp Glu Thr Ser Ile 
            260                 


<210>  163
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  163

Glu Glu Asp Val Asp Leu Gly Tyr Val Glu Asp Gly Thr Pro Cys Gly 
1               5                   10                  15      


Pro Gln Met Met Cys Leu Glu His Arg Cys Leu Pro Val Ala Ser Phe 
            20                  25                  30          


Asn Phe Ser Thr Cys Leu Ser Ser Lys Glu Gly Thr Ile Cys Ser Gly 
        35                  40                  45              


Asn Gly Val Cys Ser Asn Glu Leu Lys Cys Val Cys Asn Arg His Trp 
    50                  55                  60                  


Ile Gly Ser Asp Cys Asn Thr Tyr Phe Pro His Asn Asp Asp Ala Lys 
65                  70                  75                  80  


Thr Gly Ile Thr Leu Ser Gly Asn Gly Val Ala Gly Thr Asn Ile Ile 
                85                  90                  95      


Ile Gly Ile Ile Ala Gly Thr Ile Leu Val Leu Ala Leu Ile Leu Gly 
            100                 105                 110         


Ile Thr Ala Trp Gly Tyr Lys Asn Tyr Arg Glu Gln Arg Gln Leu Pro 
        115                 120                 125             


Gln Gly Asp Tyr Val Lys Lys Pro Gly Asp Gly Asp Ser Phe Tyr Ser 
    130                 135                 140                 


Asp Ile Pro Pro Gly Val Ser Thr Asn Ser Ala Ser Ser Ser Lys Lys 
145                 150                 155                 160 


Arg Ser Asn Gly Leu Ser His Ser Trp Ser Glu Arg Ile Pro Asp Thr 
                165                 170                 175     


Lys His Ile Ser Asp Ile Cys Glu Asn Gly Arg Pro Arg Ser Asn Ser 
            180                 185                 190         


Trp Gln Gly Asn Leu Gly Gly Asn Lys Lys Lys Ile Arg Gly Lys Arg 
        195                 200                 205             


Phe Arg Pro Arg Ser Asn Ser Thr Glu Arg Glu Pro Gln Ala Pro Glu 
    210                 215                 220                 


Pro Gly His Ser Leu Ala Gln Thr Val Pro Ser Gln Gly Ile Ser Pro 
225                 230                 235                 240 


Gly Gly Ser Asp Ser Pro Gln Thr Gly Ser Leu Asp His Arg Tyr Leu 
                245                 250                 255     


Asn Pro Trp Phe Lys Arg Asp Tyr Asn Val Ala Lys Trp Val Glu Asp 
            260                 265                 270         


Val Asn Lys Asn Thr Glu Gly Pro Tyr Phe Arg Thr Leu Ser Pro Ala 
        275                 280                 285             


Lys Ser Pro Ser Ser Ser Thr Gly Ser Ile Ala Ser Ser Arg Lys Tyr 
    290                 295                 300                 


Pro Tyr Pro Met Pro Pro Leu Pro Asp Glu Asp Lys Lys Val Asn Arg 
305                 310                 315                 320 


Gln Ser Ala Arg Leu Trp Glu Thr Ser Ile 
                325                 330 


<210>  164
<211>  1866
<212>  PRT
<213>  Homo sapiens

<400>  164

Met Asp Pro Val Gly Leu Gln Leu Gly Asn Lys Asn Leu Trp Ser Cys 
1               5                   10                  15      


Leu Val Arg Leu Leu Thr Lys Asp Pro Glu Trp Leu Asn Ala Lys Met 
            20                  25                  30          


Lys Phe Phe Leu Pro Asn Thr Asp Leu Asp Ser Arg Asn Glu Thr Leu 
        35                  40                  45              


Asp Pro Glu Gln Arg Val Ile Leu Gln Leu Asn Lys Leu His Val Gln 
    50                  55                  60                  


Gly Ser Asp Thr Trp Gln Ser Phe Ile His Cys Val Cys Met Gln Leu 
65                  70                  75                  80  


Glu Val Pro Leu Asp Leu Glu Val Leu Leu Leu Ser Thr Phe Gly Tyr 
                85                  90                  95      


Asp Asp Gly Phe Thr Ser Gln Leu Gly Ala Glu Gly Lys Ser Gln Pro 
            100                 105                 110         


Glu Ser Gln Leu His His Gly Leu Lys Arg Pro His Gln Ser Cys Gly 
        115                 120                 125             


Ser Ser Pro Arg Arg Lys Gln Cys Lys Lys Gln Gln Leu Glu Leu Ala 
    130                 135                 140                 


Lys Lys Tyr Leu Gln Leu Leu Arg Thr Ser Ala Gln Gln Arg Tyr Arg 
145                 150                 155                 160 


Ser Gln Ile Pro Gly Ser Gly Gln Pro His Ala Phe His Gln Val Tyr 
                165                 170                 175     


Val Pro Pro Ile Leu Arg Arg Ala Thr Ala Ser Leu Asp Thr Pro Glu 
            180                 185                 190         


Gly Ala Ile Met Gly Asp Val Lys Val Glu Asp Gly Ala Asp Val Ser 
        195                 200                 205             


Ile Ser Asp Leu Phe Asn Thr Arg Val Asn Lys Gly Pro Arg Val Thr 
    210                 215                 220                 


Val Leu Leu Gly Lys Ala Gly Met Gly Lys Thr Thr Leu Ala His Arg 
225                 230                 235                 240 


Leu Cys Gln Lys Trp Ala Glu Gly His Leu Asn Cys Phe Gln Ala Leu 
                245                 250                 255     


Phe Leu Phe Glu Phe Arg Gln Leu Asn Leu Ile Thr Arg Phe Leu Thr 
            260                 265                 270         


Pro Ser Glu Leu Leu Phe Asp Leu Tyr Leu Ser Pro Glu Ser Asp His 
        275                 280                 285             


Asp Thr Val Phe Gln Tyr Leu Glu Lys Asn Ala Asp Gln Val Leu Leu 
    290                 295                 300                 


Ile Phe Asp Gly Leu Asp Glu Ala Leu Gln Pro Met Gly Pro Asp Gly 
305                 310                 315                 320 


Pro Gly Pro Val Leu Thr Leu Phe Ser His Leu Cys Asn Gly Thr Leu 
                325                 330                 335     


Leu Pro Gly Cys Arg Val Met Ala Thr Ser Arg Pro Gly Lys Leu Pro 
            340                 345                 350         


Ala Cys Leu Pro Ala Glu Ala Ala Met Val His Met Leu Gly Phe Asp 
        355                 360                 365             


Gly Pro Arg Val Glu Glu Tyr Val Asn His Phe Phe Ser Ala Gln Pro 
    370                 375                 380                 


Ser Arg Glu Gly Ala Leu Val Glu Leu Gln Thr Asn Gly Arg Leu Arg 
385                 390                 395                 400 


Ser Leu Cys Ala Val Pro Ala Leu Cys Gln Val Ala Cys Leu Cys Leu 
                405                 410                 415     


His His Leu Leu Pro Asp His Ala Pro Gly Gln Ser Val Ala Leu Leu 
            420                 425                 430         


Pro Asn Met Thr Gln Leu Tyr Met Gln Met Val Leu Ala Leu Ser Pro 
        435                 440                 445             


Pro Gly His Leu Pro Thr Ser Ser Leu Leu Asp Leu Gly Glu Val Ala 
    450                 455                 460                 


Leu Arg Gly Leu Glu Thr Gly Lys Val Ile Phe Tyr Ala Lys Asp Ile 
465                 470                 475                 480 


Ala Pro Pro Leu Ile Ala Phe Gly Ala Thr His Ser Leu Leu Thr Ser 
                485                 490                 495     


Phe Cys Val Cys Thr Gly Pro Gly His Gln Gln Thr Gly Tyr Ala Phe 
            500                 505                 510         


Thr His Leu Ser Leu Gln Glu Phe Leu Ala Ala Leu His Leu Met Ala 
        515                 520                 525             


Ser Pro Lys Val Asn Lys Asp Thr Leu Thr Gln Tyr Val Thr Leu His 
    530                 535                 540                 


Ser Arg Trp Val Gln Arg Thr Lys Ala Arg Leu Gly Leu Ser Asp His 
545                 550                 555                 560 


Leu Pro Thr Phe Leu Ala Gly Leu Ala Ser Cys Thr Cys Arg Pro Phe 
                565                 570                 575     


Leu Ser His Leu Ala Gln Gly Asn Glu Asp Cys Val Gly Ala Lys Gln 
            580                 585                 590         


Ala Ala Val Val Gln Val Leu Lys Lys Leu Ala Thr Arg Lys Leu Thr 
        595                 600                 605             


Gly Pro Lys Val Val Glu Leu Cys His Cys Val Asp Glu Thr Gln Glu 
    610                 615                 620                 


Pro Glu Leu Ala Ser Leu Thr Ala Gln Ser Leu Pro Tyr Gln Leu Pro 
625                 630                 635                 640 


Phe His Asn Phe Pro Leu Thr Cys Thr Asp Leu Ala Thr Leu Thr Asn 
                645                 650                 655     


Ile Leu Glu His Arg Glu Ala Pro Ile His Leu Asp Phe Asp Gly Cys 
            660                 665                 670         


Pro Leu Glu Pro His Cys Pro Glu Ala Leu Val Gly Cys Gly Gln Ile 
        675                 680                 685             


Glu Asn Leu Ser Phe Lys Ser Arg Lys Cys Gly Asp Ala Phe Ala Glu 
    690                 695                 700                 


Ala Leu Ser Arg Ser Leu Pro Thr Met Gly Arg Leu Gln Met Leu Gly 
705                 710                 715                 720 


Leu Ala Gly Ser Lys Ile Thr Ala Arg Gly Ile Ser His Leu Val Lys 
                725                 730                 735     


Ala Leu Pro Leu Cys Pro Gln Leu Lys Glu Val Ser Phe Arg Asp Asn 
            740                 745                 750         


Gln Leu Ser Asp Gln Val Val Leu Asn Ile Val Glu Val Leu Pro His 
        755                 760                 765             


Leu Pro Arg Leu Arg Lys Leu Asp Leu Ser Ser Asn Ser Ile Cys Val 
    770                 775                 780                 


Ser Thr Leu Leu Cys Leu Ala Arg Val Ala Val Thr Cys Pro Thr Val 
785                 790                 795                 800 


Arg Met Leu Gln Ala Arg Glu Ala Asp Leu Ile Phe Leu Leu Ser Pro 
                805                 810                 815     


Pro Thr Glu Thr Thr Ala Glu Leu Gln Arg Ala Pro Asp Leu Gln Glu 
            820                 825                 830         


Ser Asp Gly Gln Arg Lys Gly Ala Gln Ser Arg Ser Leu Thr Leu Arg 
        835                 840                 845             


Leu Gln Lys Cys Gln Leu Gln Val His Asp Ala Glu Ala Leu Ile Ala 
    850                 855                 860                 


Leu Leu Gln Glu Gly Pro His Leu Glu Glu Val Asp Leu Ser Gly Asn 
865                 870                 875                 880 


Gln Leu Glu Asp Glu Gly Cys Arg Leu Met Ala Glu Ala Ala Ser Gln 
                885                 890                 895     


Leu His Ile Ala Arg Lys Leu Asp Leu Ser Asn Asn Gly Leu Ser Val 
            900                 905                 910         


Ala Gly Val His Cys Val Leu Arg Ala Val Ser Ala Cys Trp Thr Leu 
        915                 920                 925             


Ala Glu Leu His Ile Ser Leu Gln His Lys Thr Val Ile Phe Met Phe 
    930                 935                 940                 


Ala Gln Glu Pro Glu Glu Gln Lys Gly Pro Gln Glu Arg Ala Ala Phe 
945                 950                 955                 960 


Leu Asp Ser Leu Met Leu Gln Met Pro Ser Glu Leu Pro Leu Ser Ser 
                965                 970                 975     


Arg Arg Met Arg Leu Thr His Cys Gly Leu Gln Glu Lys His Leu Glu 
            980                 985                 990         


Gln Leu Cys Lys Ala Leu Gly Gly  Ser Cys His Leu Gly  His Leu His 
        995                 1000                 1005             


Leu Asp  Phe Ser Gly Asn Ala  Leu Gly Asp Glu Gly  Ala Ala Arg 
    1010                 1015                 1020             


Leu Ala  Gln Leu Leu Pro Gly  Leu Gly Ala Leu Gln  Ser Leu Asn 
    1025                 1030                 1035             


Leu Ser  Glu Asn Gly Leu Ser  Leu Asp Ala Val Leu  Gly Leu Val 
    1040                 1045                 1050             


Arg Cys  Phe Ser Thr Leu Gln  Trp Leu Phe Arg Leu  Asp Ile Ser 
    1055                 1060                 1065             


Phe Glu  Ser Gln His Ile Leu  Leu Arg Gly Asp Lys  Thr Ser Arg 
    1070                 1075                 1080             


Asp Met  Trp Ala Thr Gly Ser  Leu Pro Asp Phe Pro  Ala Ala Ala 
    1085                 1090                 1095             


Lys Phe  Leu Gly Phe Arg Gln  Arg Cys Ile Pro Arg  Ser Leu Cys 
    1100                 1105                 1110             


Leu Ser  Glu Cys Pro Leu Glu  Pro Pro Ser Leu Thr  Arg Leu Cys 
    1115                 1120                 1125             


Ala Thr  Leu Lys Asp Cys Pro  Gly Pro Leu Glu Leu  Gln Leu Ser 
    1130                 1135                 1140             


Cys Glu  Phe Leu Ser Asp Gln  Ser Leu Glu Thr Leu  Leu Asp Cys 
    1145                 1150                 1155             


Leu Pro  Gln Leu Pro Gln Leu  Ser Leu Leu Gln Leu  Ser Gln Thr 
    1160                 1165                 1170             


Gly Leu  Ser Pro Lys Ser Pro  Phe Leu Leu Ala Asn  Thr Leu Ser 
    1175                 1180                 1185             


Leu Cys  Pro Arg Val Lys Lys  Val Asp Leu Arg Ser  Leu His His 
    1190                 1195                 1200             


Ala Thr  Leu His Phe Arg Ser  Asn Glu Glu Glu Glu  Gly Val Cys 
    1205                 1210                 1215             


Cys Gly  Arg Phe Thr Gly Cys  Ser Leu Ser Gln Glu  His Val Glu 
    1220                 1225                 1230             


Ser Leu  Cys Trp Leu Leu Ser  Lys Cys Lys Asp Leu  Ser Gln Val 
    1235                 1240                 1245             


Asp Leu  Ser Ala Asn Leu Leu  Gly Asp Ser Gly Leu  Arg Cys Leu 
    1250                 1255                 1260             


Leu Glu  Cys Leu Pro Gln Val  Pro Ile Ser Gly Leu  Leu Asp Leu 
    1265                 1270                 1275             


Ser His  Asn Ser Ile Ser Gln  Glu Ser Ala Leu Tyr  Leu Leu Glu 
    1280                 1285                 1290             


Thr Leu  Pro Ser Cys Pro Arg  Val Arg Glu Ala Ser  Val Asn Leu 
    1295                 1300                 1305             


Gly Ser  Glu Gln Ser Phe Arg  Ile His Phe Ser Arg  Glu Asp Gln 
    1310                 1315                 1320             


Ala Gly  Lys Thr Leu Arg Leu  Ser Glu Cys Ser Phe  Arg Pro Glu 
    1325                 1330                 1335             


His Val  Ser Arg Leu Ala Thr  Gly Leu Ser Lys Ser  Leu Gln Leu 
    1340                 1345                 1350             


Thr Glu  Leu Thr Leu Thr Gln  Cys Cys Leu Gly Gln  Lys Gln Leu 
    1355                 1360                 1365             


Ala Ile  Leu Leu Ser Leu Val  Gly Arg Pro Ala Gly  Leu Phe Ser 
    1370                 1375                 1380             


Leu Arg  Val Gln Glu Pro Trp  Ala Asp Arg Ala Arg  Val Leu Ser 
    1385                 1390                 1395             


Leu Leu  Glu Val Cys Ala Gln  Ala Ser Gly Ser Val  Thr Glu Ile 
    1400                 1405                 1410             


Ser Ile  Ser Glu Thr Gln Gln  Gln Leu Cys Val Gln  Leu Glu Phe 
    1415                 1420                 1425             


Pro Arg  Gln Glu Glu Asn Pro  Glu Ala Val Ala Leu  Arg Leu Ala 
    1430                 1435                 1440             


His Cys  Asp Leu Gly Ala His  His Ser Leu Leu Val  Gly Gln Leu 
    1445                 1450                 1455             


Met Glu  Thr Cys Ala Arg Leu  Gln Gln Leu Ser Leu  Ser Gln Val 
    1460                 1465                 1470             


Asn Leu  Cys Glu Asp Asp Asp  Ala Ser Ser Leu Leu  Leu Gln Ser 
    1475                 1480                 1485             


Leu Leu  Leu Ser Leu Ser Glu  Leu Lys Thr Phe Arg  Leu Thr Ser 
    1490                 1495                 1500             


Ser Cys  Val Ser Thr Glu Gly  Leu Ala His Leu Ala  Ser Gly Leu 
    1505                 1510                 1515             


Gly His  Cys His His Leu Glu  Glu Leu Asp Leu Ser  Asn Asn Gln 
    1520                 1525                 1530             


Phe Asp  Glu Glu Gly Thr Lys  Ala Leu Met Arg Ala  Leu Glu Gly 
    1535                 1540                 1545             


Lys Trp  Met Leu Lys Arg Leu  Asp Leu Ser His Leu  Leu Leu Asn 
    1550                 1555                 1560             


Ser Ser  Thr Leu Ala Leu Leu  Thr His Arg Leu Ser  Gln Met Thr 
    1565                 1570                 1575             


Cys Leu  Gln Ser Leu Arg Leu  Asn Arg Asn Ser Ile  Gly Asp Val 
    1580                 1585                 1590             


Gly Cys  Cys His Leu Ser Glu  Ala Leu Arg Ala Ala  Thr Ser Leu 
    1595                 1600                 1605             


Glu Glu  Leu Asp Leu Ser His  Asn Gln Ile Gly Asp  Ala Gly Val 
    1610                 1615                 1620             


Gln His  Leu Ala Thr Ile Leu  Pro Gly Leu Pro Glu  Leu Arg Lys 
    1625                 1630                 1635             


Ile Asp  Leu Ser Gly Asn Ser  Ile Ser Ser Ala Gly  Gly Val Gln 
    1640                 1645                 1650             


Leu Ala  Glu Ser Leu Val Leu  Cys Arg Arg Leu Glu  Glu Leu Met 
    1655                 1660                 1665             


Leu Gly  Cys Asn Ala Leu Gly  Asp Pro Thr Ala Leu  Gly Leu Ala 
    1670                 1675                 1680             


Gln Glu  Leu Pro Gln His Leu  Arg Val Leu His Leu  Pro Phe Ser 
    1685                 1690                 1695             


His Leu  Gly Pro Gly Gly Ala  Leu Ser Leu Ala Gln  Ala Leu Asp 
    1700                 1705                 1710             


Gly Ser  Pro His Leu Glu Glu  Ile Ser Leu Ala Glu  Asn Asn Leu 
    1715                 1720                 1725             


Ala Gly  Gly Val Leu Arg Phe  Cys Met Glu Leu Pro  Leu Leu Arg 
    1730                 1735                 1740             


Gln Ile  Asp Leu Val Ser Cys  Lys Ile Asp Asn Gln  Thr Ala Lys 
    1745                 1750                 1755             


Leu Leu  Thr Ser Ser Phe Thr  Ser Cys Pro Ala Leu  Glu Val Ile 
    1760                 1765                 1770             


Leu Leu  Ser Trp Asn Leu Leu  Gly Asp Glu Ala Ala  Ala Glu Leu 
    1775                 1780                 1785             


Ala Gln  Val Leu Pro Gln Met  Gly Arg Leu Lys Arg  Val Asp Leu 
    1790                 1795                 1800             


Glu Lys  Asn Gln Ile Thr Ala  Leu Gly Ala Trp Leu  Leu Ala Glu 
    1805                 1810                 1815             


Gly Leu  Ala Gln Gly Ser Ser  Ile Gln Val Ile Arg  Leu Trp Asn 
    1820                 1825                 1830             


Asn Pro  Ile Pro Cys Asp Met  Ala Gln His Leu Lys  Ser Gln Glu 
    1835                 1840                 1845             


Pro Arg  Leu Asp Phe Ala Phe  Phe Asp Asn Gln Pro  Gln Ala Pro 
    1850                 1855                 1860             


Trp Gly  Thr 
    1865     


<210>  165
<211>  157
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  165

Xaa Leu Ser Ala Asn Leu Leu Gly Asp Ser Gly Leu Arg Cys Leu Leu 
1               5                   10                  15      


Glu Cys Leu Pro Gln Val Pro Ile Ser Gly Leu Leu Asp Leu Ser His 
            20                  25                  30          


Asn Ser Ile Ser Gln Glu Ser Ala Leu Tyr Leu Leu Glu Thr Leu Pro 
        35                  40                  45              


Ser Cys Pro Arg Val Arg Glu Ala Ser Val Asn Leu Gly Ser Glu Gln 
    50                  55                  60                  


Ser Phe Arg Ile His Phe Ser Arg Glu Asp Gln Ala Gly Lys Thr Leu 
65                  70                  75                  80  


Arg Leu Ser Glu Cys Ser Phe Arg Pro Glu His Val Ser Arg Leu Ala 
                85                  90                  95      


Thr Gly Leu Ser Lys Ser Leu Gln Leu Thr Glu Leu Thr Leu Thr Gln 
            100                 105                 110         


Cys Cys Leu Gly Gln Lys Gln Leu Ala Ile Leu Leu Ser Leu Val Gly 
        115                 120                 125             


Arg Pro Ala Gly Leu Phe Ser Leu Arg Leu His Lys Ala His Arg Glu 
    130                 135                 140                 


Thr Val Leu Pro His Thr Gly Gly Leu Cys Phe Gly Ile 
145                 150                 155         


<210>  166
<211>  631
<212>  PRT
<213>  Homo sapiens

<400>  166

Leu Thr Cys Thr Asp Leu Ala Thr Leu Thr Asn Ile Leu Glu His Arg 
1               5                   10                  15      


Glu Ala Pro Ile His Leu Asp Phe Asp Gly Cys Pro Leu Glu Pro His 
            20                  25                  30          


Cys Pro Glu Ala Leu Val Gly Cys Gly Gln Ile Glu Asn Leu Ser Phe 
        35                  40                  45              


Lys Ser Arg Lys Cys Gly Asp Ala Phe Ala Glu Ala Leu Ser Arg Ser 
    50                  55                  60                  


Leu Pro Thr Met Gly Arg Leu Gln Met Leu Gly Leu Ser Ser Asn Ser 
65                  70                  75                  80  


Ile Cys Val Ser Thr Leu Leu Cys Leu Ala Arg Val Ala Val Thr Cys 
                85                  90                  95      


Pro Thr Val Arg Met Leu Gln Ala Arg Glu Ala Asp Leu Ile Phe Leu 
            100                 105                 110         


Leu Ser Pro Pro Thr Glu Thr Thr Ala Glu Leu Gln Arg Ala Pro Asp 
        115                 120                 125             


Leu Gln Glu Ser Asp Gly Gln Arg Lys Gly Ala Gln Ser Arg Ser Leu 
    130                 135                 140                 


Thr Leu Arg Leu Gln Lys Cys Gln Leu Gln Val His Asp Ala Glu Ala 
145                 150                 155                 160 


Leu Ile Ala Leu Leu Gln Glu Gly Pro His Leu Glu Glu Val Asp Leu 
                165                 170                 175     


Ser Gly Asn Gln Leu Glu Asp Glu Gly Cys Arg Leu Met Ala Glu Ala 
            180                 185                 190         


Ala Ser Gln Leu His Ile Ala Arg Lys Leu Asp Leu Ser Asn Asn Gly 
        195                 200                 205             


Leu Ser Val Ala Gly Val His Cys Val Leu Arg Ala Val Ser Ala Cys 
    210                 215                 220                 


Trp Thr Leu Ala Glu Leu His Ile Ser Leu Gln His Lys Thr Val Ile 
225                 230                 235                 240 


Phe Met Phe Ala Gln Glu Pro Glu Glu Gln Lys Gly Pro Gln Glu Arg 
                245                 250                 255     


Ala Ala Phe Leu Asp Ser Leu Met Leu Gln Met Pro Ser Glu Leu Pro 
            260                 265                 270         


Leu Ser Ser Arg Arg Met Arg Leu Thr His Cys Gly Leu Gln Glu Lys 
        275                 280                 285             


His Leu Glu Gln Leu Cys Lys Ala Leu Gly Gly Ser Cys His Leu Gly 
    290                 295                 300                 


His Leu His Leu Asp Phe Ser Gly Asn Ala Leu Gly Asp Glu Gly Ala 
305                 310                 315                 320 


Ala Arg Leu Ala Gln Leu Leu Pro Gly Leu Gly Ala Leu Gln Ser Leu 
                325                 330                 335     


Asn Leu Ser Glu Asn Gly Leu Ser Leu Asp Ala Val Leu Gly Leu Val 
            340                 345                 350         


Arg Cys Phe Ser Thr Leu Gln Trp Leu Phe Arg Leu Asp Ile Ser Phe 
        355                 360                 365             


Glu Ser Gln His Ile Leu Leu Arg Gly Asp Lys Thr Ser Ser Leu Ser 
    370                 375                 380                 


Glu Cys Pro Leu Glu Pro Pro Ser Leu Thr Arg Leu Cys Ala Thr Leu 
385                 390                 395                 400 


Lys Asp Cys Pro Gly Pro Leu Glu Leu Gln Leu Ser Cys Glu Phe Leu 
                405                 410                 415     


Ser Asp Gln Ser Leu Glu Thr Leu Leu Asp Cys Leu Pro Gln Leu Pro 
            420                 425                 430         


Gln Leu Ser Leu Leu Gln Leu Ser Gln Thr Gly Leu Ser Pro Lys Ser 
        435                 440                 445             


Pro Phe Leu Leu Ala Asn Thr Leu Ser Leu Cys Pro Arg Val Lys Lys 
    450                 455                 460                 


Val Asp Leu Arg Ser Leu His His Ala Thr Leu His Phe Arg Ser Asn 
465                 470                 475                 480 


Glu Glu Glu Glu Gly Val Cys Cys Gly Arg Phe Thr Gly Cys Ser Leu 
                485                 490                 495     


Ser Gln Glu His Val Glu Ser Leu Cys Trp Leu Leu Ser Lys Cys Lys 
            500                 505                 510         


Asp Leu Ser Gln Val Asp Leu Gly Ser Glu Gln Ser Phe Arg Ile His 
        515                 520                 525             


Phe Ser Arg Glu Asp Gln Ala Gly Lys Thr Leu Arg Leu Ser Glu Cys 
    530                 535                 540                 


Ser Phe Arg Pro Glu His Val Ser Arg Leu Ala Thr Gly Leu Ser Lys 
545                 550                 555                 560 


Ser Leu Gln Leu Thr Glu Leu Thr Leu Thr Gln Cys Cys Leu Gly Gln 
                565                 570                 575     


Lys Gln Leu Ala Ile Leu Leu Ser Leu Val Gly Arg Pro Ala Gly Leu 
            580                 585                 590         


Phe Ser Leu Arg Asp Ser Thr Arg His Thr Glu Lys Leu Ser Phe Pro 
        595                 600                 605             


Thr Leu Glu Ala Cys Ala Leu Gly Phe Lys Lys Lys Arg Lys Lys Glu 
    610                 615                 620                 


Arg Lys Lys Val Ser Glu Asp 
625                 630     


<210>  167
<211>  387
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  167

Xaa Glu Leu Pro Leu Ser Ser Arg Arg Met Arg Leu Thr His Cys Gly 
1               5                   10                  15      


Leu Gln Glu Lys His Leu Glu Gln Leu Cys Lys Ala Leu Gly Gly Ser 
            20                  25                  30          


Cys His Leu Gly His Leu His Leu Asp Phe Ser Gly Asn Ala Leu Gly 
        35                  40                  45              


Asp Glu Gly Ala Ala Arg Leu Ala Gln Leu Leu Pro Gly Leu Gly Ala 
    50                  55                  60                  


Leu Gln Ser Leu Asn Leu Ser Glu Asn Gly Leu Ser Leu Asp Ala Val 
65                  70                  75                  80  


Leu Gly Leu Val Arg Cys Phe Ser Thr Leu Gln Trp Leu Phe Arg Leu 
                85                  90                  95      


Asp Ile Ser Phe Glu Ser Gln His Ile Leu Leu Arg Gly Asp Lys Thr 
            100                 105                 110         


Ser Arg Asp Met Trp Ala Thr Gly Ser Leu Pro Asp Phe Pro Ala Ala 
        115                 120                 125             


Ala Lys Phe Leu Gly Phe Arg Gln Arg Cys Ile Pro Arg Ser Leu Cys 
    130                 135                 140                 


Leu Ser Glu Cys Pro Leu Glu Pro Pro Ser Leu Thr Arg Leu Cys Ala 
145                 150                 155                 160 


Thr Leu Lys Asp Cys Pro Gly Pro Leu Glu Leu Gln Leu Ser Cys Glu 
                165                 170                 175     


Phe Leu Ser Asp Gln Ser Leu Glu Thr Leu Leu Asp Cys Leu Pro Gln 
            180                 185                 190         


Leu Pro Gln Leu Ser Leu Leu Gln Leu Ser Gln Thr Gly Leu Ser Pro 
        195                 200                 205             


Lys Ser Pro Phe Leu Leu Ala Asn Thr Leu Ser Leu Cys Pro Arg Val 
    210                 215                 220                 


Lys Lys Val Asp Leu Arg Ser Leu His His Ala Thr Leu His Phe Arg 
225                 230                 235                 240 


Ser Asn Glu Glu Glu Glu Gly Val Cys Cys Gly Leu Ser Ala Asn Leu 
                245                 250                 255     


Leu Gly Asp Ser Gly Leu Arg Cys Leu Leu Glu Cys Leu Pro Gln Val 
            260                 265                 270         


Pro Ile Ser Gly Leu Leu Asp Leu Ser His Asn Ser Ile Ser Gln Glu 
        275                 280                 285             


Ser Ala Leu Tyr Leu Leu Glu Thr Leu Pro Ser Cys Pro Arg Val Arg 
    290                 295                 300                 


Glu Ala Ser Val Asn Leu Gly Ser Glu Gln Ser Phe Arg Ile His Phe 
305                 310                 315                 320 


Ser Arg Glu Asp Gln Ala Gly Lys Thr Leu Arg Leu Ser Glu Cys Ser 
                325                 330                 335     


Phe Arg Pro Glu His Val Ser Arg Leu Ala Thr Gly Leu Ser Lys Ser 
            340                 345                 350         


Leu Gln Leu Thr Glu Leu Thr Leu Thr Gln Cys Cys Leu Gly Gln Lys 
        355                 360                 365             


Gln Leu Ala Ile Leu Leu Ser Leu Val Gly Arg Pro Ala Gly Leu Phe 
    370                 375                 380                 


Ser Leu Ser 
385         


<210>  168
<211>  1837
<212>  PRT
<213>  Homo sapiens

<400>  168

Met Asp Pro Val Gly Leu Gln Leu Gly Asn Lys Asn Leu Trp Ser Cys 
1               5                   10                  15      


Leu Val Arg Leu Leu Thr Lys Asp Pro Glu Trp Leu Asn Ala Lys Met 
            20                  25                  30          


Lys Phe Phe Leu Pro Asn Thr Asp Leu Asp Ser Arg Asn Glu Thr Leu 
        35                  40                  45              


Asp Pro Glu Gln Arg Val Ile Leu Gln Leu Asn Lys Leu His Val Gln 
    50                  55                  60                  


Gly Ser Asp Thr Trp Gln Ser Phe Ile His Cys Val Cys Met Gln Leu 
65                  70                  75                  80  


Glu Val Pro Leu Asp Leu Glu Val Leu Leu Leu Ser Thr Phe Gly Tyr 
                85                  90                  95      


Asp Asp Gly Phe Thr Ser Gln Leu Gly Ala Glu Gly Lys Ser Gln Pro 
            100                 105                 110         


Glu Ser Gln Leu His His Gly Leu Lys Arg Pro His Gln Ser Cys Gly 
        115                 120                 125             


Ser Ser Pro Arg Arg Lys Gln Cys Lys Lys Gln Gln Leu Glu Leu Ala 
    130                 135                 140                 


Lys Lys Tyr Leu Gln Leu Leu Arg Thr Ser Ala Gln Gln Arg Tyr Arg 
145                 150                 155                 160 


Ser Gln Ile Pro Gly Ser Gly Gln Pro His Ala Phe His Gln Val Tyr 
                165                 170                 175     


Val Pro Pro Ile Leu Arg Arg Ala Thr Ala Ser Leu Asp Thr Pro Glu 
            180                 185                 190         


Gly Ala Ile Met Gly Asp Val Lys Val Glu Asp Gly Ala Asp Val Ser 
        195                 200                 205             


Ile Ser Asp Leu Phe Asn Thr Arg Val Asn Lys Gly Pro Arg Val Thr 
    210                 215                 220                 


Val Leu Leu Gly Lys Ala Gly Met Gly Lys Thr Thr Leu Ala His Arg 
225                 230                 235                 240 


Leu Cys Gln Lys Trp Ala Glu Gly His Leu Asn Cys Phe Gln Ala Leu 
                245                 250                 255     


Phe Leu Phe Glu Phe Arg Gln Leu Asn Leu Ile Thr Arg Phe Leu Thr 
            260                 265                 270         


Pro Ser Glu Leu Leu Phe Asp Leu Tyr Leu Ser Pro Glu Ser Asp His 
        275                 280                 285             


Asp Thr Val Phe Gln Tyr Leu Glu Lys Asn Ala Asp Gln Val Leu Leu 
    290                 295                 300                 


Ile Phe Asp Gly Leu Asp Glu Ala Leu Gln Pro Met Gly Pro Asp Gly 
305                 310                 315                 320 


Pro Gly Pro Val Leu Thr Leu Phe Ser His Leu Cys Asn Gly Thr Leu 
                325                 330                 335     


Leu Pro Gly Cys Arg Val Met Ala Thr Ser Arg Pro Gly Lys Leu Pro 
            340                 345                 350         


Ala Cys Leu Pro Ala Glu Ala Ala Met Val His Met Leu Gly Phe Asp 
        355                 360                 365             


Gly Pro Arg Val Glu Glu Tyr Val Asn His Phe Phe Ser Ala Gln Pro 
    370                 375                 380                 


Ser Arg Glu Gly Ala Leu Val Glu Leu Gln Thr Asn Gly Arg Leu Arg 
385                 390                 395                 400 


Ser Leu Cys Ala Val Pro Ala Leu Cys Gln Val Ala Cys Leu Cys Leu 
                405                 410                 415     


His His Leu Leu Pro Asp His Ala Pro Gly Gln Ser Val Ala Leu Leu 
            420                 425                 430         


Pro Asn Met Thr Gln Leu Tyr Met Gln Met Val Leu Ala Leu Ser Pro 
        435                 440                 445             


Pro Gly His Leu Pro Thr Ser Ser Leu Leu Asp Leu Gly Glu Val Ala 
    450                 455                 460                 


Leu Arg Gly Leu Glu Thr Gly Lys Val Ile Phe Tyr Ala Lys Asp Ile 
465                 470                 475                 480 


Ala Pro Pro Leu Ile Ala Phe Gly Ala Thr His Ser Leu Leu Thr Ser 
                485                 490                 495     


Phe Cys Val Cys Thr Gly Pro Gly His Gln Gln Thr Gly Tyr Ala Phe 
            500                 505                 510         


Thr His Leu Ser Leu Gln Glu Phe Leu Ala Ala Leu His Leu Met Ala 
        515                 520                 525             


Ser Pro Lys Val Asn Lys Asp Thr Leu Thr Gln Tyr Val Thr Leu His 
    530                 535                 540                 


Ser Arg Trp Val Gln Arg Thr Lys Ala Arg Leu Gly Leu Ser Asp His 
545                 550                 555                 560 


Leu Pro Thr Phe Leu Ala Gly Leu Ala Ser Cys Thr Cys Arg Pro Phe 
                565                 570                 575     


Leu Ser His Leu Ala Gln Gly Asn Glu Asp Cys Val Gly Ala Lys Gln 
            580                 585                 590         


Ala Ala Val Val Gln Val Leu Lys Lys Leu Ala Thr Arg Lys Leu Thr 
        595                 600                 605             


Gly Pro Lys Val Val Glu Leu Cys His Cys Val Asp Glu Thr Gln Glu 
    610                 615                 620                 


Pro Glu Leu Ala Ser Leu Thr Ala Gln Ser Leu Pro Tyr Gln Leu Pro 
625                 630                 635                 640 


Phe His Asn Phe Pro Leu Thr Cys Thr Asp Leu Ala Thr Leu Thr Asn 
                645                 650                 655     


Ile Leu Glu His Arg Glu Ala Pro Ile His Leu Asp Phe Asp Gly Cys 
            660                 665                 670         


Pro Leu Glu Pro His Cys Pro Glu Ala Leu Val Gly Cys Gly Gln Ile 
        675                 680                 685             


Glu Asn Leu Ser Phe Lys Ser Arg Lys Cys Gly Asp Ala Phe Ala Glu 
    690                 695                 700                 


Ala Leu Ser Arg Ser Leu Pro Thr Met Gly Arg Leu Gln Met Leu Gly 
705                 710                 715                 720 


Leu Ala Gly Ser Lys Ile Thr Ala Arg Gly Ile Ser His Leu Val Lys 
                725                 730                 735     


Ala Leu Pro Leu Cys Pro Gln Leu Lys Glu Val Ser Phe Arg Asp Asn 
            740                 745                 750         


Gln Leu Ser Asp Gln Val Val Leu Asn Ile Val Glu Val Leu Pro His 
        755                 760                 765             


Leu Pro Arg Leu Arg Lys Leu Asp Leu Ser Ser Asn Ser Ile Cys Val 
    770                 775                 780                 


Ser Thr Leu Leu Cys Leu Ala Arg Val Ala Val Thr Cys Pro Thr Val 
785                 790                 795                 800 


Arg Met Leu Gln Ala Arg Glu Ala Asp Leu Ile Phe Leu Leu Ser Pro 
                805                 810                 815     


Pro Thr Glu Thr Thr Ala Glu Leu Gln Arg Ala Pro Asp Leu Gln Glu 
            820                 825                 830         


Ser Asp Gly Gln Arg Lys Gly Ala Gln Ser Arg Ser Leu Thr Leu Arg 
        835                 840                 845             


Leu Gln Lys Cys Gln Leu Gln Val His Asp Ala Glu Ala Leu Ile Ala 
    850                 855                 860                 


Leu Leu Gln Glu Gly Pro His Leu Glu Glu Val Asp Leu Ser Gly Asn 
865                 870                 875                 880 


Gln Leu Glu Asp Glu Gly Cys Arg Leu Met Ala Glu Ala Ala Ser Gln 
                885                 890                 895     


Leu His Ile Ala Arg Lys Leu Asp Leu Ser Asn Asn Gly Leu Ser Val 
            900                 905                 910         


Ala Gly Val His Cys Val Leu Arg Ala Val Ser Ala Cys Trp Thr Leu 
        915                 920                 925             


Ala Glu Leu His Ile Ser Leu Gln His Lys Thr Val Ile Phe Met Phe 
    930                 935                 940                 


Ala Gln Glu Pro Glu Glu Gln Lys Gly Pro Gln Glu Arg Ala Ala Phe 
945                 950                 955                 960 


Leu Asp Ser Leu Met Leu Gln Met Pro Ser Glu Leu Pro Leu Ser Ser 
                965                 970                 975     


Arg Arg Met Arg Leu Thr His Cys Gly Leu Gln Glu Lys His Leu Glu 
            980                 985                 990         


Gln Leu Cys Lys Ala Leu Gly Gly  Ser Cys His Leu Gly  His Leu His 
        995                 1000                 1005             


Leu Asp  Phe Ser Gly Asn Ala  Leu Gly Asp Glu Gly  Ala Ala Arg 
    1010                 1015                 1020             


Leu Ala  Gln Leu Leu Pro Gly  Leu Gly Ala Leu Gln  Ser Leu Asn 
    1025                 1030                 1035             


Leu Ser  Glu Asn Gly Leu Ser  Leu Asp Ala Val Leu  Gly Leu Val 
    1040                 1045                 1050             


Arg Cys  Phe Ser Thr Leu Gln  Trp Leu Phe Arg Leu  Asp Ile Ser 
    1055                 1060                 1065             


Phe Glu  Ser Gln His Ile Leu  Leu Arg Gly Asp Lys  Thr Ser Arg 
    1070                 1075                 1080             


Asp Met  Trp Ala Thr Gly Ser  Leu Pro Asp Phe Pro  Ala Ala Ala 
    1085                 1090                 1095             


Lys Phe  Leu Gly Phe Arg Gln  Arg Cys Ile Pro Arg  Ser Leu Cys 
    1100                 1105                 1110             


Leu Ser  Glu Cys Pro Leu Glu  Pro Pro Ser Leu Thr  Arg Leu Cys 
    1115                 1120                 1125             


Ala Thr  Leu Lys Asp Cys Pro  Gly Pro Leu Glu Leu  Gln Leu Ser 
    1130                 1135                 1140             


Cys Glu  Phe Leu Ser Asp Gln  Ser Leu Glu Thr Leu  Leu Asp Cys 
    1145                 1150                 1155             


Leu Pro  Gln Leu Pro Gln Leu  Ser Leu Leu Gln Leu  Ser Gln Thr 
    1160                 1165                 1170             


Gly Leu  Ser Pro Lys Ser Pro  Phe Leu Leu Ala Asn  Thr Leu Ser 
    1175                 1180                 1185             


Leu Cys  Pro Arg Val Lys Lys  Val Asp Leu Arg Ser  Leu His His 
    1190                 1195                 1200             


Ala Thr  Leu His Phe Arg Ser  Asn Glu Glu Glu Glu  Gly Val Cys 
    1205                 1210                 1215             


Cys Gly  Leu Ser Ala Asn Leu  Leu Gly Asp Ser Gly  Leu Arg Cys 
    1220                 1225                 1230             


Leu Leu  Glu Cys Leu Pro Gln  Val Pro Ile Ser Gly  Leu Leu Asp 
    1235                 1240                 1245             


Leu Ser  His Asn Ser Ile Ser  Gln Glu Ser Ala Leu  Tyr Leu Leu 
    1250                 1255                 1260             


Glu Thr  Leu Pro Ser Cys Pro  Arg Val Arg Glu Ala  Ser Val Asn 
    1265                 1270                 1275             


Leu Gly  Ser Glu Gln Ser Phe  Arg Ile His Phe Ser  Arg Glu Asp 
    1280                 1285                 1290             


Gln Ala  Gly Lys Thr Leu Arg  Leu Ser Glu Cys Ser  Phe Arg Pro 
    1295                 1300                 1305             


Glu His  Val Ser Arg Leu Ala  Thr Gly Leu Ser Lys  Ser Leu Gln 
    1310                 1315                 1320             


Leu Thr  Glu Leu Thr Leu Thr  Gln Cys Cys Leu Gly  Gln Lys Gln 
    1325                 1330                 1335             


Leu Ala  Ile Leu Leu Ser Leu  Val Gly Arg Pro Ala  Gly Leu Phe 
    1340                 1345                 1350             


Ser Leu  Arg Val Gln Glu Pro  Trp Ala Asp Arg Ala  Arg Val Leu 
    1355                 1360                 1365             


Ser Leu  Leu Glu Val Cys Ala  Gln Ala Ser Gly Ser  Val Thr Glu 
    1370                 1375                 1380             


Ile Ser  Ile Ser Glu Thr Gln  Gln Gln Leu Cys Val  Gln Leu Glu 
    1385                 1390                 1395             


Phe Pro  Arg Gln Glu Glu Asn  Pro Glu Ala Val Ala  Leu Arg Leu 
    1400                 1405                 1410             


Ala His  Cys Asp Leu Gly Ala  His His Ser Leu Leu  Val Gly Gln 
    1415                 1420                 1425             


Leu Met  Glu Thr Cys Ala Arg  Leu Gln Gln Leu Ser  Leu Ser Gln 
    1430                 1435                 1440             


Val Asn  Leu Cys Glu Asp Asp  Asp Ala Ser Ser Leu  Leu Leu Gln 
    1445                 1450                 1455             


Ser Leu  Leu Leu Ser Leu Ser  Glu Leu Lys Thr Phe  Arg Leu Thr 
    1460                 1465                 1470             


Ser Ser  Cys Val Ser Thr Glu  Gly Leu Ala His Leu  Ala Ser Gly 
    1475                 1480                 1485             


Leu Gly  His Cys His His Leu  Glu Glu Leu Asp Leu  Ser Asn Asn 
    1490                 1495                 1500             


Gln Phe  Asp Glu Glu Gly Thr  Lys Ala Leu Met Arg  Ala Leu Glu 
    1505                 1510                 1515             


Gly Lys  Trp Met Leu Lys Arg  Leu Asp Leu Ser His  Leu Leu Leu 
    1520                 1525                 1530             


Asn Ser  Ser Thr Leu Ala Leu  Leu Thr His Arg Leu  Ser Gln Met 
    1535                 1540                 1545             


Thr Cys  Leu Gln Ser Leu Arg  Leu Asn Arg Asn Ser  Ile Gly Asp 
    1550                 1555                 1560             


Val Gly  Cys Cys His Leu Ser  Glu Ala Leu Arg Ala  Ala Thr Ser 
    1565                 1570                 1575             


Leu Glu  Glu Leu Asp Leu Ser  His Asn Gln Ile Gly  Asp Ala Gly 
    1580                 1585                 1590             


Val Gln  His Leu Ala Thr Ile  Leu Pro Gly Leu Pro  Glu Leu Arg 
    1595                 1600                 1605             


Lys Ile  Asp Leu Ser Gly Asn  Ser Ile Ser Ser Ala  Gly Gly Val 
    1610                 1615                 1620             


Gln Leu  Ala Glu Ser Leu Val  Leu Cys Arg Arg Leu  Glu Glu Leu 
    1625                 1630                 1635             


Met Leu  Gly Cys Asn Ala Leu  Gly Asp Pro Thr Ala  Leu Gly Leu 
    1640                 1645                 1650             


Ala Gln  Glu Leu Pro Gln His  Leu Arg Val Leu His  Leu Pro Phe 
    1655                 1660                 1665             


Ser His  Leu Gly Pro Gly Gly  Ala Leu Ser Leu Ala  Gln Ala Leu 
    1670                 1675                 1680             


Asp Gly  Ser Pro His Leu Glu  Glu Ile Ser Leu Ala  Glu Asn Asn 
    1685                 1690                 1695             


Leu Ala  Gly Gly Val Leu Arg  Phe Cys Met Glu Leu  Pro Leu Leu 
    1700                 1705                 1710             


Arg Gln  Ile Asp Leu Val Ser  Cys Lys Ile Asp Asn  Gln Thr Ala 
    1715                 1720                 1725             


Lys Leu  Leu Thr Ser Ser Phe  Thr Ser Cys Pro Ala  Leu Glu Val 
    1730                 1735                 1740             


Ile Leu  Leu Ser Trp Asn Leu  Leu Gly Asp Glu Ala  Ala Ala Glu 
    1745                 1750                 1755             


Leu Ala  Gln Val Leu Pro Gln  Met Gly Arg Leu Lys  Arg Val Asp 
    1760                 1765                 1770             


Leu Glu  Lys Asn Gln Ile Thr  Ala Leu Gly Ala Trp  Leu Leu Ala 
    1775                 1780                 1785             


Glu Gly  Leu Ala Gln Gly Ser  Ser Ile Gln Val Ile  Arg Leu Trp 
    1790                 1795                 1800             


Asn Asn  Pro Ile Pro Cys Asp  Met Ala Gln His Leu  Lys Ser Gln 
    1805                 1810                 1815             


Glu Pro  Arg Leu Asp Phe Ala  Phe Phe Asp Asn Gln  Pro Gln Ala 
    1820                 1825                 1830             


Pro Trp  Gly Thr 
    1835         


<210>  169
<211>  1057
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  169

Xaa Ser Glu Leu Leu Phe Asp Leu Tyr Leu Ser Pro Glu Ser Asp His 
1               5                   10                  15      


Asp Thr Val Phe Gln Tyr Leu Glu Lys Asn Ala Asp Gln Val Leu Leu 
            20                  25                  30          


Ile Phe Asp Gly Leu Asp Glu Ala Leu Gln Pro Met Gly Pro Asp Gly 
        35                  40                  45              


Pro Gly Pro Val Leu Thr Leu Phe Ser His Leu Cys Asn Gly Thr Leu 
    50                  55                  60                  


Leu Pro Gly Cys Arg Val Met Ala Thr Ser Arg Pro Gly Lys Leu Pro 
65                  70                  75                  80  


Ala Cys Leu Pro Ala Glu Ala Ala Met Val His Met Leu Gly Phe Asp 
                85                  90                  95      


Gly Pro Arg Val Glu Glu Tyr Val Asn His Phe Phe Ser Ala Gln Pro 
            100                 105                 110         


Ser Arg Glu Gly Ala Leu Val Glu Leu Gln Thr Asn Gly Arg Leu Arg 
        115                 120                 125             


Ser Leu Cys Ala Val Pro Ala Leu Cys Gln Val Ala Cys Leu Cys Leu 
    130                 135                 140                 


His His Leu Leu Pro Asp His Ala Pro Gly Gln Ser Val Ala Leu Leu 
145                 150                 155                 160 


Pro Asn Met Thr Gln Leu Tyr Met Gln Met Val Leu Ala Leu Ser Pro 
                165                 170                 175     


Pro Gly His Leu Pro Thr Ser Ser Leu Leu Asp Leu Gly Glu Val Ala 
            180                 185                 190         


Leu Arg Gly Leu Glu Thr Gly Lys Val Ile Phe Tyr Ala Lys Asp Ile 
        195                 200                 205             


Ala Pro Pro Leu Ile Ala Phe Gly Ala Thr His Ser Leu Leu Thr Ser 
    210                 215                 220                 


Phe Cys Val Cys Thr Gly Pro Gly His Gln Gln Thr Gly Tyr Ala Phe 
225                 230                 235                 240 


Thr His Leu Ser Leu Gln Glu Phe Leu Ala Ala Leu His Leu Met Ala 
                245                 250                 255     


Ser Pro Lys Val Asn Lys Asp Thr Leu Thr Gln Tyr Val Thr Leu His 
            260                 265                 270         


Ser Arg Trp Val Gln Arg Thr Lys Ala Arg Leu Gly Leu Ser Asp His 
        275                 280                 285             


Leu Pro Thr Phe Leu Ala Gly Leu Ala Ser Cys Thr Cys Arg Pro Phe 
    290                 295                 300                 


Leu Ser His Leu Ala Gln Gly Asn Glu Asp Cys Val Gly Ala Lys Gln 
305                 310                 315                 320 


Ala Ala Val Val Gln Val Leu Lys Lys Leu Ala Thr Arg Lys Leu Thr 
                325                 330                 335     


Gly Pro Lys Val Val Glu Leu Cys His Cys Val Asp Glu Thr Gln Glu 
            340                 345                 350         


Pro Glu Leu Ala Ser Leu Thr Ala Gln Ser Leu Pro Tyr Gln Leu Pro 
        355                 360                 365             


Phe His Asn Phe Pro Leu Thr Cys Thr Asp Leu Ala Thr Leu Thr Asn 
    370                 375                 380                 


Ile Leu Glu His Arg Glu Ala Pro Ile His Leu Asp Phe Asp Gly Cys 
385                 390                 395                 400 


Pro Leu Glu Pro His Cys Pro Glu Ala Leu Val Gly Cys Gly Gln Ile 
                405                 410                 415     


Glu Asn Leu Ser Phe Lys Ser Arg Lys Cys Gly Asp Ala Phe Ala Glu 
            420                 425                 430         


Ala Leu Ser Arg Ser Leu Pro Thr Met Gly Arg Leu Gln Met Leu Gly 
        435                 440                 445             


Leu Ala Gly Ser Lys Ile Thr Ala Arg Gly Ile Ser His Leu Val Lys 
    450                 455                 460                 


Ala Leu Pro Leu Cys Pro Gln Leu Lys Glu Val Ser Phe Arg Asp Asn 
465                 470                 475                 480 


Gln Leu Ser Asp Gln Val Val Leu Asn Ile Val Glu Val Leu Pro His 
                485                 490                 495     


Leu Pro Arg Leu Arg Lys Leu Asp Leu Ser Ser Asn Ser Ile Cys Val 
            500                 505                 510         


Ser Thr Leu Leu Cys Leu Ala Arg Val Ala Val Thr Cys Pro Thr Val 
        515                 520                 525             


Arg Met Leu Gln Ala Arg Glu Ala Asp Leu Ile Phe Leu Leu Ser Pro 
    530                 535                 540                 


Pro Thr Glu Thr Thr Ala Glu Leu Gln Arg Ala Pro Asp Leu Gln Glu 
545                 550                 555                 560 


Ser Asp Gly Gln Arg Lys Gly Ala Gln Ser Arg Ser Leu Thr Leu Arg 
                565                 570                 575     


Leu Gln Lys Cys Gln Leu Gln Val His Asp Ala Glu Ala Leu Ile Ala 
            580                 585                 590         


Leu Leu Gln Glu Gly Pro His Leu Glu Glu Val Asp Leu Ser Gly Asn 
        595                 600                 605             


Gln Leu Glu Asp Glu Gly Cys Arg Leu Met Ala Glu Ala Ala Ser Gln 
    610                 615                 620                 


Leu His Ile Ala Arg Lys Leu Asp Leu Ser Asn Asn Gly Leu Ser Val 
625                 630                 635                 640 


Ala Gly Val His Cys Val Leu Arg Ala Val Ser Ala Cys Trp Thr Leu 
                645                 650                 655     


Ala Glu Leu His Ile Ser Leu Gln His Lys Thr Val Ile Phe Met Phe 
            660                 665                 670         


Ala Gln Glu Pro Glu Glu Gln Lys Gly Pro Gln Glu Arg Ala Ala Phe 
        675                 680                 685             


Leu Asp Ser Leu Met Leu Gln Met Pro Ser Glu Leu Pro Leu Ser Ser 
    690                 695                 700                 


Arg Arg Met Arg Leu Thr His Cys Gly Leu Gln Glu Lys His Leu Glu 
705                 710                 715                 720 


Gln Leu Cys Lys Ala Leu Gly Gly Ser Cys His Leu Gly His Leu His 
                725                 730                 735     


Leu Asp Phe Ser Gly Asn Ala Leu Gly Asp Glu Gly Ala Ala Arg Leu 
            740                 745                 750         


Ala Gln Leu Leu Pro Gly Leu Gly Ala Leu Gln Ser Leu Asn Leu Ser 
        755                 760                 765             


Glu Asn Gly Leu Ser Leu Asp Ala Val Leu Gly Leu Val Arg Cys Phe 
    770                 775                 780                 


Ser Thr Leu Gln Trp Leu Phe Arg Leu Asp Ile Ser Phe Glu Ser Gln 
785                 790                 795                 800 


His Ile Leu Leu Arg Gly Asp Lys Thr Ser Arg Asp Met Trp Ala Thr 
                805                 810                 815     


Gly Ser Leu Pro Asp Phe Pro Ala Ala Ala Lys Phe Leu Gly Phe Arg 
            820                 825                 830         


Gln Arg Cys Ile Pro Arg Ser Leu Cys Leu Ser Glu Cys Pro Leu Glu 
        835                 840                 845             


Pro Pro Ser Leu Thr Arg Leu Cys Ala Thr Leu Lys Asp Cys Pro Gly 
    850                 855                 860                 


Pro Leu Glu Leu Gln Leu Ser Cys Glu Phe Leu Ser Asp Gln Ser Leu 
865                 870                 875                 880 


Glu Thr Leu Leu Asp Cys Leu Pro Gln Leu Pro Gln Leu Ser Leu Leu 
                885                 890                 895     


Gln Leu Ser Gln Thr Gly Leu Ser Pro Lys Ser Pro Phe Leu Leu Ala 
            900                 905                 910         


Asn Thr Leu Ser Leu Cys Pro Arg Val Lys Lys Val Asp Leu Arg Ser 
        915                 920                 925             


Leu His His Ala Thr Leu His Phe Arg Ser Asn Glu Glu Glu Glu Gly 
    930                 935                 940                 


Val Cys Cys Gly Arg Phe Thr Gly Cys Ser Leu Ser Gln Glu His Val 
945                 950                 955                 960 


Glu Ser Leu Cys Trp Leu Leu Ser Lys Cys Lys Asp Leu Ser Gln Val 
                965                 970                 975     


Asp Leu Ser Ala Asn Leu Leu Gly Asp Ser Gly Leu Arg Cys Leu Leu 
            980                 985                 990         


Glu Cys Leu Pro Gln Val Pro Ile  Ser Gly Leu Leu Asp  Leu Ser His 
        995                 1000                 1005             


Asn Ser  Ile Ser Gln Glu Ser  Ala Leu Tyr Leu Leu  Glu Thr Leu 
    1010                 1015                 1020             


Pro Ser  Cys Pro Arg Val Arg  Glu Ala Ser Val Lys  Cys Leu Gly 
    1025                 1030                 1035             


Ser Trp  His Val Trp Ala Pro  Cys Phe Pro Arg Pro  Phe Ser Leu 
    1040                 1045                 1050             


Gln Pro  Gly Leu 
    1055         


<210>  170
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  170

Met Asp Pro Val Gly Leu Gln Leu Gly Asn Lys Asn Leu Trp Ser Cys 
1               5                   10                  15      


Leu Val Arg Leu Leu Thr Lys Asp Pro Glu Trp Leu Asn Ala Lys Met 
            20                  25                  30          


Lys Phe Phe Leu Pro Asn Thr Asp Leu Asp Ser Arg Asn Glu Thr Leu 
        35                  40                  45              


Asp Pro Glu Gln Arg Val Ile Leu Gln Leu Asn Lys Leu His Val Gln 
    50                  55                  60                  


Gly Ser Asp Thr Trp Gln Ser Phe Ile His 
65                  70                  


<210>  171
<211>  110
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  171

Xaa Ala Ser Gly Leu Gly His Cys His His Leu Glu Glu Leu Asp Leu 
1               5                   10                  15      


Ser Asn Asn Gln Phe Asp Glu Glu Gly Thr Lys Ala Leu Met Arg Ala 
            20                  25                  30          


Leu Glu Gly Lys Trp Met Leu Lys Arg Leu Asp Leu Ser His Leu Leu 
        35                  40                  45              


Leu Asn Ser Ser Thr Leu Ala Leu Leu Thr His Arg Leu Ser Gln Met 
    50                  55                  60                  


Thr Cys Leu Gln Ser Leu Ser Leu Thr Leu Ser Pro Arg Leu Glu Cys 
65                  70                  75                  80  


Ser Gly Met Ile Ser Leu His Cys Asn Leu Cys Leu Leu Gly Ser Ser 
                85                  90                  95      


Asp Ser Gly Ala Ser Ala Ala Gln Val Ala Gly Ile Thr Asp 
            100                 105                 110 


<210>  172
<211>  702
<212>  PRT
<213>  Homo sapiens

<400>  172

Gln Lys Cys Gln Leu Gln Val His Asp Ala Glu Ala Leu Ile Ala Leu 
1               5                   10                  15      


Leu Gln Glu Gly Pro His Leu Glu Glu Val Asp Leu Ser Gly Asn Gln 
            20                  25                  30          


Leu Glu Asp Glu Gly Cys Arg Leu Met Ala Glu Ala Ala Ser Gln Leu 
        35                  40                  45              


His Ile Ala Arg Lys Leu Asp Leu Ser Asn Asn Gly Leu Ser Val Ala 
    50                  55                  60                  


Gly Val His Cys Val Leu Arg Ala Val Ser Ala Cys Trp Thr Leu Ala 
65                  70                  75                  80  


Glu Leu His Ile Ser Leu Gln His Lys Thr Val Ile Phe Met Phe Ala 
                85                  90                  95      


Gln Glu Pro Glu Glu Gln Lys Gly Pro Gln Glu Arg Ala Ala Phe Leu 
            100                 105                 110         


Asp Ser Leu Met Leu Gln Met Pro Ser Glu Leu Pro Leu Ser Ser Arg 
        115                 120                 125             


Arg Met Arg Leu Thr His Cys Gly Leu Gln Glu Lys His Leu Glu Gln 
    130                 135                 140                 


Leu Cys Lys Ala Leu Gly Gly Ser Cys His Leu Gly His Leu His Leu 
145                 150                 155                 160 


Asp Phe Ser Gly Asn Ala Leu Gly Asp Glu Gly Ala Ala Arg Leu Ala 
                165                 170                 175     


Gln Leu Leu Pro Gly Leu Gly Ala Leu Gln Ser Leu Asn Leu Ser Glu 
            180                 185                 190         


Asn Gly Leu Ser Leu Asp Ala Val Leu Gly Leu Val Arg Cys Phe Ser 
        195                 200                 205             


Thr Leu Gln Trp Leu Phe Arg Leu Asp Ile Ser Phe Glu Ser Gln His 
    210                 215                 220                 


Ile Leu Leu Arg Gly Asp Lys Thr Ser Arg Asp Met Trp Ala Thr Gly 
225                 230                 235                 240 


Ser Leu Pro Asp Phe Pro Ala Ala Ala Lys Phe Leu Gly Phe Arg Gln 
                245                 250                 255     


Arg Cys Ile Pro Arg Ser Leu Cys Leu Ser Glu Cys Pro Leu Glu Pro 
            260                 265                 270         


Pro Ser Leu Thr Arg Leu Cys Ala Thr Leu Lys Asp Cys Pro Gly Pro 
        275                 280                 285             


Leu Glu Leu Gln Leu Ser Cys Glu Phe Leu Ser Asp Gln Ser Leu Glu 
    290                 295                 300                 


Thr Leu Leu Asp Cys Leu Pro Gln Leu Pro Gln Leu Ser Leu Leu Gln 
305                 310                 315                 320 


Leu Ser Gln Thr Gly Leu Ser Pro Lys Ser Pro Phe Leu Leu Ala Asn 
                325                 330                 335     


Thr Leu Ser Leu Cys Pro Arg Val Lys Lys Val Asp Leu Arg Ser Leu 
            340                 345                 350         


His His Ala Thr Leu His Phe Arg Ser Asn Glu Glu Glu Glu Gly Val 
        355                 360                 365             


Cys Cys Gly Arg Phe Thr Gly Cys Ser Leu Ser Gln Glu His Val Glu 
    370                 375                 380                 


Ser Leu Cys Trp Leu Leu Ser Lys Cys Lys Asp Leu Ser Gln Val Asp 
385                 390                 395                 400 


Leu Ser Ala Asn Leu Leu Gly Asp Ser Gly Leu Arg Cys Leu Leu Glu 
                405                 410                 415     


Cys Leu Pro Gln Val Pro Ile Ser Gly Leu Leu Asp Leu Ser His Asn 
            420                 425                 430         


Ser Ile Ser Gln Glu Ser Ala Leu Tyr Leu Leu Glu Thr Leu Pro Ser 
        435                 440                 445             


Cys Pro Arg Val Arg Glu Ala Ser Val Asn Leu Gly Ser Glu Gln Ser 
    450                 455                 460                 


Phe Arg Ile His Phe Ser Arg Glu Asp Gln Ala Gly Lys Thr Leu Arg 
465                 470                 475                 480 


Leu Ser Glu Cys Ser Phe Arg Pro Glu His Val Ser Arg Leu Ala Thr 
                485                 490                 495     


Gly Leu Ser Lys Ser Leu Gln Leu Thr Glu Leu Thr Leu Thr Gln Cys 
            500                 505                 510         


Cys Leu Gly Gln Lys Gln Leu Ala Ile Leu Leu Ser Leu Val Gly Arg 
        515                 520                 525             


Pro Ala Gly Leu Phe Ser Leu Arg Val Gln Glu Pro Trp Ala Asp Arg 
    530                 535                 540                 


Ala Arg Val Leu Ser Leu Leu Glu Val Cys Ala Gln Ala Ser Gly Ser 
545                 550                 555                 560 


Val Thr Glu Ile Ser Ile Ser Glu Thr Gln Gln Gln Leu Cys Val Gln 
                565                 570                 575     


Leu Glu Phe Pro Arg Gln Glu Glu Asn Pro Glu Ala Val Ala Leu Arg 
            580                 585                 590         


Leu Ala His Cys Asp Leu Gly Ala His His Ser Leu Leu Val Gly Gln 
        595                 600                 605             


Leu Met Glu Thr Cys Ala Arg Leu Gln Gln Leu Ser Leu Ser Gln Val 
    610                 615                 620                 


Asn Leu Cys Glu Asp Asp Asp Ala Ser Ser Leu Leu Leu Gln Ser Leu 
625                 630                 635                 640 


Leu Leu Ser Leu Ser Glu Leu Lys Thr Phe Arg Ile Gln Ser Ser Gln 
                645                 650                 655     


Asp Pro Gly Arg Leu Leu Pro Asp Leu Leu Pro Phe Asp Pro His Gln 
            660                 665                 670         


Ala Asp Leu Gln Leu Cys Glu His Arg Gly Pro Arg Pro Pro Gly Ile 
        675                 680                 685             


Trp Ser Gly Pro Leu Pro Pro Leu Gly Gly Ala Gly Leu Val 
    690                 695                 700         


<210>  173
<211>  1180
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  173

Xaa His Leu Asn Cys Phe Gln Ala Leu Phe Leu Phe Glu Phe Arg Gln 
1               5                   10                  15      


Leu Asn Leu Ile Thr Arg Phe Leu Thr Pro Ser Glu Leu Leu Phe Asp 
            20                  25                  30          


Leu Tyr Leu Ser Pro Glu Ser Asp His Asp Thr Val Phe Gln Tyr Leu 
        35                  40                  45              


Glu Lys Asn Ala Asp Gln Val Leu Leu Ile Phe Asp Gly Leu Asp Glu 
    50                  55                  60                  


Ala Leu Gln Pro Met Gly Pro Asp Gly Pro Gly Pro Val Leu Thr Leu 
65                  70                  75                  80  


Phe Ser His Leu Cys Asn Gly Thr Leu Leu Pro Gly Cys Arg Val Met 
                85                  90                  95      


Ala Thr Ser Arg Pro Gly Lys Leu Pro Ala Cys Leu Pro Ala Glu Ala 
            100                 105                 110         


Ala Met Val His Met Leu Gly Phe Asp Gly Pro Arg Val Glu Glu Tyr 
        115                 120                 125             


Val Asn His Phe Phe Ser Ala Gln Pro Ser Arg Glu Gly Ala Leu Val 
    130                 135                 140                 


Glu Leu Gln Thr Asn Gly Arg Leu Arg Ser Leu Cys Ala Val Pro Ala 
145                 150                 155                 160 


Leu Cys Gln Val Ala Cys Leu Cys Leu His His Leu Leu Pro Asp His 
                165                 170                 175     


Ala Pro Gly Gln Ser Val Ala Leu Leu Pro Asn Met Thr Gln Leu Tyr 
            180                 185                 190         


Met Gln Met Val Leu Ala Leu Ser Pro Pro Gly His Leu Pro Thr Ser 
        195                 200                 205             


Ser Leu Leu Asp Leu Gly Glu Val Ala Leu Arg Gly Leu Glu Thr Gly 
    210                 215                 220                 


Lys Val Ile Phe Tyr Ala Lys Asp Ile Ala Pro Pro Leu Ile Ala Phe 
225                 230                 235                 240 


Gly Ala Thr His Ser Leu Leu Thr Ser Phe Cys Val Cys Thr Gly Pro 
                245                 250                 255     


Gly His Gln Gln Thr Gly Tyr Ala Phe Thr His Leu Ser Leu Gln Glu 
            260                 265                 270         


Phe Leu Ala Ala Leu His Leu Met Ala Ser Pro Lys Val Asn Lys Asp 
        275                 280                 285             


Thr Leu Thr Gln Tyr Val Thr Leu His Ser Arg Trp Val Gln Arg Thr 
    290                 295                 300                 


Lys Ala Arg Leu Gly Leu Ser Asp His Leu Pro Thr Phe Leu Ala Gly 
305                 310                 315                 320 


Leu Ala Ser Cys Thr Cys Arg Pro Phe Leu Ser His Leu Ala Gln Gly 
                325                 330                 335     


Asn Glu Asp Cys Val Gly Ala Lys Gln Ala Ala Val Val Gln Val Leu 
            340                 345                 350         


Lys Lys Leu Ala Thr Arg Lys Leu Thr Gly Pro Lys Val Val Glu Leu 
        355                 360                 365             


Cys His Cys Val Asp Glu Thr Gln Glu Pro Glu Leu Ala Ser Leu Thr 
    370                 375                 380                 


Ala Gln Ser Leu Pro Tyr Gln Leu Pro Phe His Asn Phe Pro Leu Thr 
385                 390                 395                 400 


Cys Thr Asp Leu Ala Thr Leu Thr Asn Ile Leu Glu His Arg Glu Ala 
                405                 410                 415     


Pro Ile His Leu Asp Phe Asp Gly Cys Pro Leu Glu Pro His Cys Pro 
            420                 425                 430         


Glu Ala Leu Val Gly Cys Gly Gln Ile Glu Asn Leu Ser Phe Lys Ser 
        435                 440                 445             


Arg Lys Cys Gly Asp Ala Phe Ala Glu Ala Leu Ser Arg Ser Leu Pro 
    450                 455                 460                 


Thr Met Gly Arg Leu Gln Met Leu Gly Leu Ala Gly Ser Lys Ile Thr 
465                 470                 475                 480 


Ala Arg Gly Ile Ser His Leu Val Lys Ala Leu Pro Leu Cys Pro Gln 
                485                 490                 495     


Leu Lys Glu Val Ser Phe Arg Asp Asn Gln Leu Ser Asp Gln Val Val 
            500                 505                 510         


Leu Asn Ile Val Glu Val Leu Pro His Leu Pro Arg Leu Arg Lys Leu 
        515                 520                 525             


Asp Leu Ser Ser Asn Ser Ile Cys Val Ser Thr Leu Leu Cys Leu Ala 
    530                 535                 540                 


Arg Val Ala Val Thr Cys Pro Thr Val Arg Met Leu Gln Ala Arg Glu 
545                 550                 555                 560 


Ala Asp Leu Ile Phe Leu Leu Ser Pro Pro Thr Glu Thr Thr Ala Glu 
                565                 570                 575     


Leu Gln Arg Ala Pro Asp Leu Gln Glu Ser Asp Gly Gln Arg Lys Gly 
            580                 585                 590         


Ala Gln Ser Arg Ser Leu Thr Leu Arg Leu Gln Lys Cys Gln Leu Gln 
        595                 600                 605             


Val His Asp Ala Glu Ala Leu Ile Ala Leu Leu Gln Glu Gly Pro His 
    610                 615                 620                 


Leu Glu Glu Val Asp Leu Ser Gly Asn Gln Leu Glu Asp Glu Gly Cys 
625                 630                 635                 640 


Arg Leu Met Ala Glu Ala Ala Ser Gln Leu His Ile Ala Arg Lys Leu 
                645                 650                 655     


Asp Leu Ser Asn Asn Gly Leu Ser Val Ala Gly Val His Cys Val Leu 
            660                 665                 670         


Arg Ala Val Ser Ala Cys Trp Thr Leu Ala Glu Leu His Ile Ser Leu 
        675                 680                 685             


Gln His Lys Thr Val Ile Phe Met Phe Ala Gln Glu Pro Glu Glu Gln 
    690                 695                 700                 


Lys Gly Pro Gln Glu Arg Ala Ala Phe Leu Asp Ser Leu Met Leu Gln 
705                 710                 715                 720 


Met Pro Ser Glu Leu Pro Leu Ser Ser Arg Arg Met Arg Leu Thr His 
                725                 730                 735     


Cys Gly Leu Gln Glu Lys His Leu Glu Gln Leu Cys Lys Ala Leu Gly 
            740                 745                 750         


Gly Ser Cys His Leu Gly His Leu His Leu Asp Phe Ser Gly Asn Ala 
        755                 760                 765             


Leu Gly Asp Glu Gly Ala Ala Arg Leu Ala Gln Leu Leu Pro Gly Leu 
    770                 775                 780                 


Gly Ala Leu Gln Ser Leu Asn Leu Ser Glu Asn Gly Leu Ser Leu Asp 
785                 790                 795                 800 


Ala Val Leu Gly Leu Val Arg Cys Phe Ser Thr Leu Gln Trp Leu Phe 
                805                 810                 815     


Arg Leu Asp Ile Ser Phe Glu Ser Gln His Ile Leu Leu Arg Gly Asp 
            820                 825                 830         


Lys Thr Ser Arg Asp Met Trp Ala Thr Gly Ser Leu Pro Asp Phe Pro 
        835                 840                 845             


Ala Ala Ala Lys Phe Leu Gly Phe Arg Gln Arg Cys Ile Pro Arg Ser 
    850                 855                 860                 


Leu Cys Leu Ser Glu Cys Pro Leu Glu Pro Pro Ser Leu Thr Arg Leu 
865                 870                 875                 880 


Cys Ala Thr Leu Lys Asp Cys Pro Gly Pro Leu Glu Leu Gln Leu Ser 
                885                 890                 895     


Cys Glu Phe Leu Ser Asp Gln Ser Leu Glu Thr Leu Leu Asp Cys Leu 
            900                 905                 910         


Pro Gln Leu Pro Gln Leu Ser Leu Leu Gln Leu Ser Gln Thr Gly Leu 
        915                 920                 925             


Ser Pro Lys Ser Pro Phe Leu Leu Ala Asn Thr Leu Ser Leu Cys Pro 
    930                 935                 940                 


Arg Val Lys Lys Val Asp Leu Arg Ser Leu His His Ala Thr Leu His 
945                 950                 955                 960 


Phe Arg Ser Asn Glu Glu Glu Glu Gly Val Cys Cys Gly Phe Thr Gly 
                965                 970                 975     


Cys Ser Leu Ser Gln Glu His Val Glu Ser Leu Cys Trp Leu Leu Ser 
            980                 985                 990         


Lys Cys Lys Asp Leu Ser Gln Val  Asp Leu Ser Ala Asn  Leu Leu Gly 
        995                 1000                 1005             


Asp Ser  Gly Leu Arg Cys Leu  Leu Glu Cys Leu Pro  Gln Val Pro 
    1010                 1015                 1020             


Ile Ser  Gly Leu Leu Asp Leu  Ser His Asn Ser Ile  Ser Gln Glu 
    1025                 1030                 1035             


Ser Ala  Leu Tyr Leu Leu Glu  Thr Leu Pro Ser Cys  Pro Arg Val 
    1040                 1045                 1050             


Arg Glu  Ala Ser Val Asn Leu  Gly Ser Glu Gln Ser  Phe Arg Ile 
    1055                 1060                 1065             


His Phe  Ser Arg Glu Asp Gln  Ala Gly Lys Thr Leu  Arg Leu Ser 
    1070                 1075                 1080             


Glu Cys  Ser Phe Arg Pro Glu  His Val Ser Arg Leu  Ala Thr Gly 
    1085                 1090                 1095             


Leu Ser  Lys Ser Leu Gln Leu  Thr Glu Leu Thr Leu  Thr Gln Cys 
    1100                 1105                 1110             


Cys Leu  Gly Gln Lys Gln Leu  Ala Ile Leu Leu Ser  Leu Val Gly 
    1115                 1120                 1125             


Arg Pro  Ala Gly Leu Phe Ser  Leu Arg Asp Ser Thr  Arg His Thr 
    1130                 1135                 1140             


Glu Lys  Leu Ser Phe Pro Thr  Leu Glu Ala Cys Ala  Leu Gly Phe 
    1145                 1150                 1155             


Lys Lys  Lys Arg Lys Lys Glu  Arg Lys Lys Val Ser  Glu Asp Thr 
    1160                 1165                 1170             


Glu Leu  Arg Thr Lys Ile Asn  
    1175                 1180 


<210>  174
<211>  885
<212>  PRT
<213>  Homo sapiens

<400>  174

Leu Thr Ser Phe Cys Val Cys Thr Gly Pro Gly His Gln Gln Thr Gly 
1               5                   10                  15      


Tyr Ala Phe Thr His Leu Ser Leu Gln Glu Phe Leu Ala Ala Leu His 
            20                  25                  30          


Leu Met Ala Ser Pro Lys Val Asn Lys Asp Thr Leu Thr Gln Tyr Val 
        35                  40                  45              


Thr Leu His Ser Arg Trp Val Gln Arg Thr Lys Ala Arg Leu Gly Leu 
    50                  55                  60                  


Ser Asp His Leu Pro Thr Phe Leu Ala Gly Leu Ala Ser Cys Thr Cys 
65                  70                  75                  80  


Arg Pro Phe Leu Ser His Leu Ala Gln Gly Asn Glu Asp Cys Val Gly 
                85                  90                  95      


Ala Lys Gln Ala Ala Val Val Gln Val Leu Lys Lys Leu Ala Thr Arg 
            100                 105                 110         


Lys Leu Thr Gly Pro Lys Val Val Glu Leu Cys His Cys Val Asp Glu 
        115                 120                 125             


Thr Gln Glu Pro Glu Leu Ala Ser Leu Thr Ala Gln Ser Leu Pro Tyr 
    130                 135                 140                 


Gln Leu Pro Phe His Asn Phe Pro Leu Thr Cys Thr Asp Leu Ala Thr 
145                 150                 155                 160 


Leu Thr Asn Ile Leu Glu His Arg Glu Ala Pro Ile His Leu Asp Phe 
                165                 170                 175     


Asp Gly Cys Pro Leu Glu Pro His Cys Pro Glu Ala Leu Val Gly Cys 
            180                 185                 190         


Gly Gln Ile Glu Asn Leu Ser Phe Lys Ser Arg Lys Cys Gly Asp Ala 
        195                 200                 205             


Phe Ala Glu Ala Leu Ser Arg Ser Leu Pro Thr Met Gly Arg Leu Gln 
    210                 215                 220                 


Met Leu Gly Leu Ala Gly Ser Lys Ile Thr Ala Arg Gly Ile Ser His 
225                 230                 235                 240 


Leu Val Lys Ala Leu Pro Leu Cys Pro Gln Leu Lys Glu Val Ser Phe 
                245                 250                 255     


Arg Asp Asn Gln Leu Ser Asp Gln Val Val Leu Asn Ile Val Glu Val 
            260                 265                 270         


Leu Pro His Leu Pro Arg Leu Arg Lys Leu Asp Leu Ser Ser Asn Ser 
        275                 280                 285             


Ile Cys Val Ser Thr Leu Leu Cys Leu Ala Arg Val Ala Val Thr Cys 
    290                 295                 300                 


Pro Thr Val Arg Met Leu Gln Ala Arg Glu Ala Asp Leu Ile Phe Leu 
305                 310                 315                 320 


Leu Ser Pro Pro Thr Glu Thr Thr Ala Glu Leu Gln Arg Ala Pro Asp 
                325                 330                 335     


Leu Gln Glu Ser Asp Gly Gln Arg Lys Gly Ala Gln Ser Arg Ser Leu 
            340                 345                 350         


Thr Leu Arg Leu Gln Lys Cys Gln Leu Gln Val His Asp Ala Glu Ala 
        355                 360                 365             


Leu Ile Ala Leu Leu Gln Glu Gly Pro His Leu Glu Glu Val Asp Leu 
    370                 375                 380                 


Ser Gly Asn Gln Leu Glu Asp Glu Gly Cys Arg Leu Met Ala Glu Ala 
385                 390                 395                 400 


Ala Ser Gln Leu His Ile Ala Arg Lys Leu Asp Leu Ser Asn Asn Gly 
                405                 410                 415     


Leu Ser Val Ala Gly Val His Cys Val Leu Arg Ala Val Ser Ala Cys 
            420                 425                 430         


Trp Thr Leu Ala Glu Leu His Ile Ser Leu Gln His Lys Thr Val Ile 
        435                 440                 445             


Phe Met Phe Ala Gln Glu Pro Glu Glu Gln Lys Gly Pro Gln Glu Arg 
    450                 455                 460                 


Ala Ala Phe Leu Asp Ser Leu Met Leu Gln Met Pro Ser Glu Leu Pro 
465                 470                 475                 480 


Leu Ser Ser Arg Arg Met Arg Leu Thr His Cys Gly Leu Gln Glu Lys 
                485                 490                 495     


His Leu Glu Gln Leu Cys Lys Ala Leu Gly Gly Ser Cys His Leu Gly 
            500                 505                 510         


His Leu His Leu Asp Phe Ser Gly Asn Ala Leu Gly Asp Glu Gly Ala 
        515                 520                 525             


Ala Arg Leu Ala Gln Leu Leu Pro Gly Leu Gly Ala Leu Gln Ser Leu 
    530                 535                 540                 


Asn Leu Ser Glu Asn Gly Leu Ser Leu Asp Ala Val Leu Gly Leu Val 
545                 550                 555                 560 


Arg Cys Phe Ser Thr Leu Gln Trp Leu Phe Arg Leu Asp Ile Ser Phe 
                565                 570                 575     


Glu Ser Gln His Ile Leu Leu Arg Gly Asp Lys Thr Ser Ser Leu Ser 
            580                 585                 590         


Glu Cys Pro Leu Glu Pro Pro Ser Leu Thr Arg Leu Cys Ala Thr Leu 
        595                 600                 605             


Lys Asp Cys Pro Gly Pro Leu Glu Leu Gln Leu Ser Cys Glu Phe Leu 
    610                 615                 620                 


Ser Asp Gln Ser Leu Glu Thr Leu Leu Asp Cys Leu Pro Gln Leu Pro 
625                 630                 635                 640 


Gln Leu Ser Leu Leu Gln Leu Ser Gln Thr Gly Leu Ser Pro Lys Ser 
                645                 650                 655     


Pro Phe Leu Leu Ala Asn Thr Leu Ser Leu Cys Pro Arg Val Lys Lys 
            660                 665                 670         


Val Asp Leu Arg Ser Leu His His Ala Thr Leu His Phe Arg Ser Asn 
        675                 680                 685             


Glu Glu Glu Glu Gly Val Cys Cys Gly Phe Thr Gly Cys Ser Leu Ser 
    690                 695                 700                 


Gln Glu His Val Glu Ser Leu Cys Trp Leu Leu Ser Lys Cys Lys Asp 
705                 710                 715                 720 


Leu Ser Gln Val Asp Leu Ser Ala Asn Leu Leu Gly Asp Ser Gly Leu 
                725                 730                 735     


Arg Cys Leu Leu Glu Cys Leu Pro Gln Val Pro Ile Ser Gly Leu Leu 
            740                 745                 750         


Asp Leu Ser His Asn Ser Ile Ser Gln Glu Ser Ala Leu Tyr Leu Leu 
        755                 760                 765             


Glu Thr Leu Pro Ser Cys Pro Arg Val Arg Glu Ala Ser Val Asn Leu 
    770                 775                 780                 


Gly Ser Glu Gln Ser Phe Arg Ile His Phe Ser Arg Glu Asp Gln Ala 
785                 790                 795                 800 


Gly Lys Thr Leu Arg Leu Ser Glu Cys Ser Phe Arg Pro Glu His Val 
                805                 810                 815     


Ser Arg Leu Ala Thr Gly Leu Ser Lys Ser Leu Gln Leu Thr Glu Leu 
            820                 825                 830         


Thr Leu Thr Gln Cys Cys Leu Gly Gln Lys Gln Leu Ala Ile Leu Leu 
        835                 840                 845             


Ser Leu Val Gly Arg Pro Ala Gly Leu Phe Ser Leu Arg Asp Ser Thr 
    850                 855                 860                 


Arg His Thr Glu Lys Leu Ser Phe Pro Thr Leu Glu Ala Cys Ala Leu 
865                 870                 875                 880 


Gly Phe Lys Lys Lys 
                885 


<210>  175
<211>  325
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  175

Xaa Trp Leu Phe Arg Leu Asp Ile Ser Phe Glu Ser Gln His Ile Leu 
1               5                   10                  15      


Leu Arg Gly Asp Lys Thr Ser Arg Asp Met Trp Ala Thr Gly Ser Leu 
            20                  25                  30          


Pro Asp Phe Pro Ala Ala Ala Lys Phe Leu Gly Phe Arg Gln Arg Cys 
        35                  40                  45              


Ile Pro Arg Ser Leu Cys Leu Ser Glu Cys Pro Leu Glu Pro Pro Ser 
    50                  55                  60                  


Leu Thr Arg Leu Cys Ala Thr Leu Lys Asp Cys Pro Gly Pro Leu Glu 
65                  70                  75                  80  


Leu Gln Leu Ser Cys Glu Phe Leu Ser Asp Gln Ser Leu Glu Thr Leu 
                85                  90                  95      


Leu Asp Cys Leu Pro Gln Leu Pro Gln Leu Ser Leu Leu Gln Leu Ser 
            100                 105                 110         


Gln Thr Gly Leu Ser Pro Lys Ser Pro Phe Leu Leu Ala Asn Thr Leu 
        115                 120                 125             


Ser Leu Cys Pro Arg Val Lys Lys Val Asp Leu Arg Ser Leu His His 
    130                 135                 140                 


Ala Thr Leu His Phe Arg Ser Asn Glu Glu Glu Glu Gly Val Cys Cys 
145                 150                 155                 160 


Gly Phe Thr Gly Cys Ser Leu Ser Gln Glu His Val Glu Ser Leu Cys 
                165                 170                 175     


Trp Leu Leu Ser Lys Cys Lys Asp Leu Ser Gln Val Asp Leu Ser Ala 
            180                 185                 190         


Asn Leu Leu Gly Asp Ser Gly Leu Arg Cys Leu Leu Glu Cys Leu Pro 
        195                 200                 205             


Gln Val Pro Ile Ser Gly Leu Leu Asp Leu Ser His Asn Ser Ile Ser 
    210                 215                 220                 


Gln Glu Ser Ala Leu Tyr Leu Leu Glu Thr Leu Pro Ser Cys Pro Arg 
225                 230                 235                 240 


Val Arg Glu Ala Ser Val Asn Leu Gly Ser Glu Gln Ser Phe Arg Ile 
                245                 250                 255     


His Phe Ser Arg Glu Asp Gln Ala Gly Lys Thr Leu Arg Leu Ser Glu 
            260                 265                 270         


Cys Ser Phe Arg Pro Glu His Val Ser Arg Leu Ala Thr Gly Leu Ser 
        275                 280                 285             


Lys Ser Leu Gln Leu Thr Glu Leu Thr Leu Thr Gln Cys Cys Leu Gly 
    290                 295                 300                 


Gln Lys Gln Leu Ala Ile Leu Leu Ser Leu Val Gly Arg Pro Ala Gly 
305                 310                 315                 320 


Leu Phe Ser Leu Ser 
                325 


<210>  176
<211>  720
<212>  PRT
<213>  Homo sapiens

<400>  176

Met Asp Pro Val Gly Leu Gln Leu Gly Asn Lys Asn Leu Trp Ser Cys 
1               5                   10                  15      


Leu Val Arg Leu Leu Thr Lys Asp Pro Glu Trp Leu Asn Ala Lys Met 
            20                  25                  30          


Lys Phe Phe Leu Pro Asn Thr Asp Leu Asp Ser Arg Asn Glu Thr Leu 
        35                  40                  45              


Asp Pro Glu Gln Arg Val Ile Leu Gln Leu Asn Lys Leu His Val Gln 
    50                  55                  60                  


Gly Ser Asp Thr Trp Gln Ser Phe Ile His Cys Val Cys Met Gln Leu 
65                  70                  75                  80  


Glu Val Pro Leu Asp Leu Glu Val Leu Leu Leu Ser Thr Phe Gly Tyr 
                85                  90                  95      


Asp Asp Gly Phe Thr Ser Gln Leu Gly Ala Glu Gly Lys Ser Gln Pro 
            100                 105                 110         


Glu Ser Gln Leu His His Gly Leu Lys Arg Pro His Gln Ser Cys Gly 
        115                 120                 125             


Ser Ser Pro Arg Arg Lys Gln Cys Lys Lys Gln Gln Leu Glu Leu Ala 
    130                 135                 140                 


Lys Lys Tyr Leu Gln Leu Leu Arg Thr Ser Ala Gln Gln Arg Tyr Arg 
145                 150                 155                 160 


Ser Gln Ile Pro Gly Ser Gly Gln Pro His Ala Phe His Gln Val Tyr 
                165                 170                 175     


Val Pro Pro Ile Leu Arg Arg Ala Thr Ala Ser Leu Asp Thr Pro Glu 
            180                 185                 190         


Gly Ala Ile Met Gly Asp Val Lys Val Glu Asp Gly Ala Asp Val Ser 
        195                 200                 205             


Ile Ser Asp Leu Phe Asn Thr Arg Val Asn Lys Gly Pro Arg Val Thr 
    210                 215                 220                 


Val Leu Leu Gly Lys Ala Gly Met Gly Lys Thr Thr Leu Ala His Arg 
225                 230                 235                 240 


Leu Cys Gln Lys Trp Ala Glu Gly His Leu Asn Cys Phe Gln Ala Leu 
                245                 250                 255     


Phe Leu Phe Glu Phe Arg Gln Leu Asn Leu Ile Thr Arg Phe Leu Thr 
            260                 265                 270         


Pro Ser Glu Leu Leu Phe Asp Leu Tyr Leu Ser Pro Glu Ser Asp His 
        275                 280                 285             


Asp Thr Val Phe Gln Tyr Leu Glu Lys Asn Ala Asp Gln Val Leu Leu 
    290                 295                 300                 


Ile Phe Asp Gly Leu Asp Glu Ala Leu Gln Pro Met Gly Pro Asp Gly 
305                 310                 315                 320 


Pro Gly Pro Val Leu Thr Leu Phe Ser His Leu Cys Asn Gly Thr Leu 
                325                 330                 335     


Leu Pro Gly Cys Arg Val Met Ala Thr Ser Arg Pro Gly Lys Leu Pro 
            340                 345                 350         


Ala Cys Leu Pro Ala Glu Ala Ala Met Val His Met Leu Gly Phe Asp 
        355                 360                 365             


Gly Pro Arg Val Glu Glu Tyr Val Asn His Phe Phe Ser Ala Gln Pro 
    370                 375                 380                 


Ser Arg Glu Gly Ala Leu Val Glu Leu Gln Thr Asn Gly Arg Leu Arg 
385                 390                 395                 400 


Ser Leu Cys Ala Val Pro Ala Leu Cys Gln Val Ala Cys Leu Cys Leu 
                405                 410                 415     


His His Leu Leu Pro Asp His Ala Pro Gly Gln Ser Val Ala Leu Leu 
            420                 425                 430         


Pro Asn Met Thr Gln Leu Tyr Met Gln Met Val Leu Ala Leu Ser Pro 
        435                 440                 445             


Pro Gly His Leu Pro Thr Ser Ser Leu Leu Asp Leu Gly Glu Val Ala 
    450                 455                 460                 


Leu Arg Gly Leu Glu Thr Gly Lys Val Ile Phe Tyr Ala Lys Asp Ile 
465                 470                 475                 480 


Ala Pro Pro Leu Ile Ala Phe Gly Ala Thr His Ser Leu Leu Thr Ser 
                485                 490                 495     


Phe Cys Val Cys Thr Gly Pro Gly His Gln Gln Thr Gly Tyr Ala Phe 
            500                 505                 510         


Thr His Leu Ser Leu Gln Glu Phe Leu Ala Ala Leu His Leu Met Ala 
        515                 520                 525             


Ser Pro Lys Val Asn Lys Asp Thr Leu Thr Gln Tyr Val Thr Leu His 
    530                 535                 540                 


Ser Arg Trp Val Gln Arg Thr Lys Ala Arg Leu Gly Leu Ser Asp His 
545                 550                 555                 560 


Leu Pro Thr Phe Leu Ala Gly Leu Ala Ser Cys Thr Cys Arg Pro Phe 
                565                 570                 575     


Leu Ser His Leu Ala Gln Gly Asn Glu Asp Cys Val Gly Ala Lys Gln 
            580                 585                 590         


Ala Ala Val Val Gln Val Leu Lys Lys Leu Ala Thr Arg Lys Leu Thr 
        595                 600                 605             


Gly Pro Lys Val Val Glu Leu Cys His Cys Val Asp Glu Thr Gln Glu 
    610                 615                 620                 


Pro Glu Leu Ala Ser Leu Thr Ala Gln Ser Leu Pro Tyr Gln Leu Pro 
625                 630                 635                 640 


Phe His Asn Phe Pro Leu Thr Cys Thr Asp Leu Ala Thr Leu Thr Asn 
                645                 650                 655     


Ile Leu Glu His Arg Glu Ala Pro Ile His Leu Asp Phe Asp Gly Cys 
            660                 665                 670         


Pro Leu Glu Pro His Cys Pro Glu Ala Leu Val Gly Cys Gly Gln Ile 
        675                 680                 685             


Glu Asn Leu Ser Phe Lys Ser Arg Lys Cys Gly Asp Ala Phe Ala Glu 
    690                 695                 700                 


Ala Leu Ser Arg Ser Leu Pro Thr Met Gly Arg Leu Gln Met Leu Gly 
705                 710                 715                 720 


<210>  177
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  177

Met Asp Pro Val Gly Leu Gln Leu Gly Asn Lys Asn Leu Trp Ser Cys 
1               5                   10                  15      


Leu Val Arg 
            


<210>  178
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  178

Met Pro Ile Thr Arg Met Arg Met Arg Pro Trp Leu Glu Met Gln Ile 
1               5                   10                  15      


Asn Ser Asn Gln Ile Pro Gly Leu Ile Trp Ile Asn Lys Glu Glu Met 
            20                  25                  30          


Ile Phe Gln Ile Pro Trp Lys His Ala Ala Lys His Gly Trp Asp Ile 
        35                  40                  45              


Asn Lys Asp Ala Cys Leu Phe Arg Ser Trp Ala Ile His Thr Gly Arg 
    50                  55                  60                  


Tyr Lys Ala Gly Glu Lys Glu Pro Asp Pro Lys Thr Trp Lys Ala Asn 
65                  70                  75                  80  


Phe Arg Cys Ala Met Asn Ser Leu Pro Asp Ile Glu Glu Val Lys Asp 
                85                  90                  95      


Gln Ser Arg Asn Lys Gly Ser Ser Ala Val Arg Val Tyr Arg Met Leu 
            100                 105                 110         


Pro Pro Leu Thr Lys Asn Gln Arg Lys Glu Arg Lys Ser Lys Ser Ser 
        115                 120                 125             


Arg Asp Ala Lys Ser Lys Ala Lys Arg Lys Ser Cys Gly Asp Ser Ser 
    130                 135                 140                 


Pro Asp Thr Phe Ser Asp Gly Leu Ser Ser Ser Thr Leu Pro Asp Asp 
145                 150                 155                 160 


His Ser Ser Tyr Thr Val Pro Gly Tyr Met Gln Asp Leu Glu Val Glu 
                165                 170                 175     


Gln Ala Leu Thr Pro Ala Leu Ser Pro Cys Ala Val Ser Ser Thr Leu 
            180                 185                 190         


Pro Asp Trp His Ile Pro Val Glu Val Val Pro Asp Ser Thr Ser Asp 
        195                 200                 205             


Leu Tyr Asn Phe Gln Val Ser Pro Met Pro Ser Thr Ser Glu Ala Thr 
    210                 215                 220                 


Thr Asp Glu Asp Glu Glu Gly Lys Leu Pro Glu Asp Ile Met Lys Leu 
225                 230                 235                 240 


Leu Glu Gln Ser Glu Trp Gln Pro Thr Asn Val Asp Gly Lys Gly Tyr 
                245                 250                 255     


Leu Leu Asn Glu Pro Gly Val Gln Pro Thr Ser Val Tyr Gly Asp Phe 
            260                 265                 270         


Ser Cys Lys Glu Glu Pro Glu Ile Asp Ser Pro Gly Gly Asp Ile Gly 
        275                 280                 285             


Leu Ser Leu Gln Arg Val Phe Thr Asp Leu Lys Asn Met Asp Ala Thr 
    290                 295                 300                 


Trp Leu Asp Ser Leu Leu Thr Pro Val Arg Leu Pro Ser Ile Gln Ala 
305                 310                 315                 320 


Ile Pro Cys Ala Pro 
                325 


<210>  179
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  179

Met Pro Ile Thr Arg Met Arg Met Arg Pro Trp Leu Glu Met Gln Ile 
1               5                   10                  15      


Asn Ser Asn Gln Ile Pro Gly Leu Ile Trp Ile Asn Lys Glu Glu Met 
            20                  25                  30          


Ile Phe Gln Ile Pro Trp Lys His Ala Ala Lys His Gly Trp Asp Ile 
        35                  40                  45              


Asn Lys Asp Ala Cys Leu Phe Arg Ser Trp Ala Ile His Thr Gly Arg 
    50                  55                  60                  


Tyr Lys Ala Gly Glu Lys Glu Pro Asp Pro Lys Thr Trp Lys Ala Asn 
65                  70                  75                  80  


Phe Arg Cys Ala Met Asn Ser Leu Pro Asp Ile Glu Glu Val Lys Asp 
                85                  90                  95      


Gln Ser Arg Asn Lys Gly Ser Ser Ala Val Arg Val Tyr Arg Met Leu 
            100                 105                 110         


Pro Pro Leu Thr Lys Asn Gln Arg Lys Glu Arg Lys Ser Lys Ser Ser 
        115                 120                 125             


Arg Asp Ala Lys Ser Lys Ala Lys Arg Lys Ser Cys Gly Asp Ser Ser 
    130                 135                 140                 


Pro Asp Thr Phe Ser Asp Gly Leu Ser Ser Ser Thr Leu Pro Asp Asp 
145                 150                 155                 160 


His Ser Ser Tyr Thr Val Pro Gly Tyr Met Gln Asp Leu Glu Val Glu 
                165                 170                 175     


Gln Ala Leu Thr Pro Ala Leu Ser Pro Cys Ala Val Ser Ser Thr Leu 
            180                 185                 190         


<210>  180
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  180

Met Pro Ile Thr Arg Met Arg Met Arg Pro Trp Leu Glu Met Gln Ile 
1               5                   10                  15      


Asn Ser Asn Gln Ile Pro Gly Leu Ile Trp Ile Asn Lys Glu Glu Met 
            20                  25                  30          


Ile Phe Gln Ile Pro Trp Lys His Ala Ala Lys His Gly Trp Asp Ile 
        35                  40                  45              


Asn Lys Asp Ala Cys Leu Phe Arg Ser Trp Ala Ile His Thr Gly Arg 
    50                  55                  60                  


Tyr Lys Ala Gly Glu Lys Glu Pro Asp Pro Lys Thr Trp Lys Ala Asn 
65                  70                  75                  80  


Phe Arg Cys Ala Met Asn Ser Leu Pro Asp Ile Glu Glu Val Lys Asp 
                85                  90                  95      


Gln Ser Arg Asn Lys Gly Ser Ser Ala Val Arg Val Tyr Arg Met Leu 
            100                 105                 110         


Pro Pro Leu Thr Lys Asn Gln Arg Lys Glu Arg Lys Ser Lys Ser Ser 
        115                 120                 125             


Arg Asp Ala Lys Ser Lys Ala Lys Arg Lys Ser Cys Gly Asp Ser Ser 
    130                 135                 140                 


Pro Asp Thr Phe Ser Asp Gly Leu Ser Ser Ser Thr Leu Pro Asp Asp 
145                 150                 155                 160 


His Ser Ser Tyr Thr Val Pro Gly Tyr Met Gln Asp Leu Glu Val Glu 
                165                 170                 175     


Gln Ala Leu Thr Pro Ala Thr Thr Asp Glu Asp Glu Glu Gly Lys Leu 
            180                 185                 190         


Pro Glu Asp Ile Met Lys 
        195             


<210>  181
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  181

Met Pro Ile Thr Arg Met Arg Met Arg Pro Trp Leu Glu Met Gln Ile 
1               5                   10                  15      


Asn Ser Asn Gln Ile Pro Gly Leu Ile Trp Ile Asn Lys Ala Asp Thr 
            20                  25                  30          


Lys Gln Gly Lys Arg Ser Gln Ile Pro Arg Arg Gly Arg Pro Thr Phe 
        35                  40                  45              


Ala Val Pro 
    50      


<210>  182
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  182

Met Pro Ile Thr Arg Met Arg Met Arg Pro Trp Leu Glu Met Gln Ile 
1               5                   10                  15      


Asn Ser Asn Gln Ile Pro Gly Leu Ile Trp Ile Asn Lys Glu Glu Met 
            20                  25                  30          


Ile Phe Gln Ile Pro Trp Lys His Ala Ala Lys His Gly Trp Asp Ile 
        35                  40                  45              


Asn Lys Asp Ala Cys Leu Phe Arg Ser Trp Ala Ile His Thr Gly Arg 
    50                  55                  60                  


Tyr Lys Ala Gly Glu Lys Glu Pro Asp Pro Lys Thr Trp Lys Ala Asn 
65                  70                  75                  80  


Phe Arg Cys Ala Met Asn Ser Leu Pro Asp Ile Glu Glu Val Lys Asp 
                85                  90                  95      


Gln Ser Arg Asn Lys Gly Ser Ser Ala Val Arg Val Tyr Arg Met Leu 
            100                 105                 110         


Pro Pro Leu Thr Lys Asn 
        115             


<210>  183
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  183

Met Pro Ile Thr Arg Met Arg Met Arg Pro Trp Leu Glu Met Gln Ile 
1               5                   10                  15      


Asn Ser Asn Gln Ile Pro Gly Leu Ile Trp Ile Asn Lys Glu Glu Met 
            20                  25                  30          


Ile Phe Gln Ile Pro Trp Lys His Ala Ala Lys His Gly Trp Asp Ile 
        35                  40                  45              


Asn Lys Asp Ala Cys Leu Phe Arg Ser Trp Ala Ile His Thr Gly Arg 
    50                  55                  60                  


Tyr Lys Ala Gly Glu Lys Glu Pro Asp Pro Lys Thr Trp Lys Ala Asn 
65                  70                  75                  80  


Phe Arg Cys Ala Met Asn Ser Leu Pro Asp Ile Glu Glu Val Lys Asp 
                85                  90                  95      


Gln Ser Arg Asn Lys Gly Ser Ser Ala Val Arg Val Tyr Arg Met Leu 
            100                 105                 110         


Pro Pro Leu Thr Lys Asn Gln Arg Lys Glu Arg Lys Ser Lys Ser Ser 
        115                 120                 125             


Arg Asp Ala Lys Ser Lys Ala Lys Arg Lys Ser Cys Gly Asp Ser Ser 
    130                 135                 140                 


Pro Asp Thr Phe Ser Asp Gly Leu Ser Ser Ser Thr Leu Pro Asp Asp 
145                 150                 155                 160 


His Ser Ser Tyr Thr Val Pro Gly Tyr Met Gln Asp Leu Glu Val Glu 
                165                 170                 175     


Gln Ala Leu Thr Pro Ala Leu Gly Ala Val Gly Val Ala Ala Asn Lys 
            180                 185                 190         


Arg Gly Trp Glu Gly Val Pro Thr Gln 
        195                 200     


<210>  184
<211>  2863
<212>  PRT
<213>  Homo sapiens

<400>  184

Met Ala Ser Glu Asp Asn Arg Val Pro Ser Pro Pro Pro Thr Gly Asp 
1               5                   10                  15      


Asp Gly Gly Gly Gly Gly Arg Glu Glu Thr Pro Thr Glu Gly Gly Ala 
            20                  25                  30          


Leu Ser Leu Lys Pro Gly Leu Pro Ile Arg Gly Ile Arg Met Lys Phe 
        35                  40                  45              


Ala Val Leu Thr Gly Leu Val Glu Val Gly Glu Val Ser Asn Arg Asp 
    50                  55                  60                  


Ile Val Glu Thr Val Phe Asn Leu Leu Val Gly Gly Gln Phe Asp Leu 
65                  70                  75                  80  


Glu Met Asn Phe Ile Ile Gln Glu Gly Glu Ser Ile Asn Cys Met Val 
                85                  90                  95      


Asp Leu Leu Glu Lys Cys Asp Ile Thr Cys Gln Ala Glu Val Trp Ser 
            100                 105                 110         


Met Phe Thr Ala Ile Leu Lys Lys Ser Ile Arg Asn Leu Gln Val Cys 
        115                 120                 125             


Thr Glu Val Gly Leu Val Glu Lys Val Leu Gly Lys Ile Glu Lys Val 
    130                 135                 140                 


Asp Asn Met Ile Ala Asp Leu Leu Val Asp Met Leu Gly Val Leu Ala 
145                 150                 155                 160 


Ser Tyr Asn Leu Thr Val Arg Glu Leu Lys Leu Phe Phe Ser Lys Leu 
                165                 170                 175     


Gln Gly Asp Lys Gly Arg Trp Pro Pro His Ala Gly Lys Leu Leu Ser 
            180                 185                 190         


Val Leu Lys His Met Pro Gln Lys Tyr Gly Pro Asp Ala Phe Phe Asn 
        195                 200                 205             


Phe Pro Gly Lys Ser Ala Ala Ala Ile Ala Leu Pro Pro Ile Ala Lys 
    210                 215                 220                 


Trp Pro Tyr Gln Asn Gly Phe Thr Phe His Thr Trp Leu Arg Met Asp 
225                 230                 235                 240 


Pro Val Asn Asn Ile Asn Val Asp Lys Asp Lys Pro Tyr Leu Tyr Cys 
                245                 250                 255     


Phe Arg Thr Ser Lys Gly Leu Gly Tyr Ser Ala His Phe Val Gly Gly 
            260                 265                 270         


Cys Leu Ile Val Thr Ser Ile Lys Ser Lys Gly Lys Gly Phe Gln His 
        275                 280                 285             


Cys Val Lys Phe Asp Phe Lys Pro Gln Lys Trp Tyr Met Val Thr Ile 
    290                 295                 300                 


Val His Ile Tyr Asn Arg Trp Lys Asn Ser Glu Leu Arg Cys Tyr Val 
305                 310                 315                 320 


Asn Gly Glu Leu Ala Ser Tyr Gly Glu Ile Thr Trp Phe Val Asn Thr 
                325                 330                 335     


Ser Asp Thr Phe Asp Lys Cys Phe Leu Gly Ser Ser Glu Thr Ala Asp 
            340                 345                 350         


Ala Asn Arg Val Phe Cys Gly Gln Met Thr Ala Val Tyr Leu Phe Ser 
        355                 360                 365             


Glu Ala Leu Asn Ala Ala Gln Ile Phe Ala Ile Tyr Gln Leu Gly Leu 
    370                 375                 380                 


Gly Tyr Lys Gly Thr Phe Lys Phe Lys Ala Glu Ser Asp Leu Phe Leu 
385                 390                 395                 400 


Ala Glu His His Lys Leu Leu Leu Tyr Asp Gly Lys Leu Ser Ser Ala 
                405                 410                 415     


Ile Ala Phe Thr Tyr Asn Pro Arg Ala Thr Asp Ala Gln Leu Cys Leu 
            420                 425                 430         


Glu Ser Ser Pro Lys Asp Asn Pro Ser Ile Phe Val His Ser Pro His 
        435                 440                 445             


Ala Leu Met Leu Gln Asp Val Lys Ala Val Leu Thr His Ser Ile Gln 
    450                 455                 460                 


Ser Ala Met His Ser Ile Gly Gly Val Gln Val Leu Phe Pro Leu Phe 
465                 470                 475                 480 


Ala Gln Leu Asp Tyr Arg Gln Tyr Leu Ser Asp Glu Ile Asp Leu Thr 
                485                 490                 495     


Ile Cys Ser Thr Leu Leu Ala Phe Ile Met Glu Leu Leu Lys Asn Ser 
            500                 505                 510         


Ile Ala Met Gln Glu Gln Met Leu Ala Cys Lys Gly Phe Leu Val Ile 
        515                 520                 525             


Gly Tyr Ser Leu Glu Lys Ser Ser Lys Ser His Val Ser Arg Ala Val 
    530                 535                 540                 


Leu Glu Leu Cys Leu Ala Phe Ser Lys Tyr Leu Ser Asn Leu Gln Asn 
545                 550                 555                 560 


Gly Met Pro Leu Leu Lys Gln Leu Cys Asp His Val Leu Leu Asn Pro 
                565                 570                 575     


Ala Ile Trp Ile His Thr Pro Ala Lys Val Gln Leu Met Leu Tyr Thr 
            580                 585                 590         


Tyr Leu Ser Thr Glu Phe Ile Gly Thr Val Asn Ile Tyr Asn Thr Ile 
        595                 600                 605             


Arg Arg Val Gly Thr Val Leu Leu Ile Met His Thr Leu Lys Tyr Tyr 
    610                 615                 620                 


Tyr Trp Ala Val Asn Pro Gln Asp Arg Ser Gly Ile Thr Pro Lys Gly 
625                 630                 635                 640 


Leu Asp Gly Pro Arg Pro Asn Gln Lys Glu Met Leu Ser Leu Arg Ala 
                645                 650                 655     


Phe Leu Leu Met Phe Ile Lys Gln Leu Val Met Lys Asp Ser Gly Val 
            660                 665                 670         


Lys Glu Asp Glu Leu Gln Ala Ile Leu Asn Tyr Leu Leu Thr Met His 
        675                 680                 685             


Glu Asp Asp Asn Leu Met Asp Val Leu Gln Leu Leu Val Ala Leu Met 
    690                 695                 700                 


Ser Glu His Pro Asn Ser Met Ile Pro Ala Phe Asp Gln Arg Asn Gly 
705                 710                 715                 720 


Leu Arg Val Ile Tyr Lys Leu Leu Ala Ser Lys Ser Glu Gly Ile Arg 
                725                 730                 735     


Val Gln Ala Leu Lys Ala Met Gly Tyr Phe Leu Lys His Leu Ala Pro 
            740                 745                 750         


Lys Arg Lys Ala Glu Val Met Leu Gly His Gly Leu Phe Ser Leu Leu 
        755                 760                 765             


Ala Glu Arg Leu Met Leu Gln Thr Asn Leu Ile Thr Met Thr Thr Tyr 
    770                 775                 780                 


Asn Val Leu Phe Glu Ile Leu Ile Glu Gln Ile Gly Thr Gln Val Ile 
785                 790                 795                 800 


His Lys Gln His Pro Asp Pro Asp Ser Ser Val Lys Ile Gln Asn Pro 
                805                 810                 815     


Gln Ile Leu Lys Val Ile Ala Thr Leu Leu Arg Asn Ser Pro Gln Cys 
            820                 825                 830         


Pro Glu Ser Met Glu Val Arg Arg Ala Phe Leu Ser Asp Met Ile Lys 
        835                 840                 845             


Leu Phe Asn Asn Ser Arg Glu Asn Arg Arg Ser Leu Leu Gln Cys Ser 
    850                 855                 860                 


Val Trp Gln Glu Trp Met Leu Ser Leu Cys Tyr Phe Asn Pro Lys Asn 
865                 870                 875                 880 


Ser Asp Glu Gln Lys Ile Thr Glu Met Val Tyr Ala Ile Phe Arg Ile 
                885                 890                 895     


Leu Leu Tyr His Ala Val Lys Tyr Glu Trp Gly Gly Trp Arg Val Trp 
            900                 905                 910         


Val Asp Thr Leu Ser Ile Thr His Ser Lys Val Thr Phe Glu Ile His 
        915                 920                 925             


Lys Glu Asn Leu Ala Asn Ile Phe Arg Glu Gln Gln Gly Lys Val Asp 
    930                 935                 940                 


Glu Glu Ile Gly Leu Cys Ser Ser Thr Ser Val Gln Ala Ala Ser Gly 
945                 950                 955                 960 


Ile Arg Arg Asp Ile Asn Val Ser Val Gly Ser Gln Gln Pro Asp Thr 
                965                 970                 975     


Lys Asp Ser Pro Val Cys Pro His Phe Thr Thr Asn Gly Asn Glu Asn 
            980                 985                 990         


Ser Ser Ile Glu Lys Thr Ser Ser  Leu Glu Ser Ala Ser  Asn Ile Glu 
        995                 1000                 1005             


Leu Gln  Thr Thr Asn Thr Ser  Tyr Glu Glu Met Lys  Ala Glu Gln 
    1010                 1015                 1020             


Glu Asn  Gln Glu Leu Pro Asp  Glu Gly Thr Leu Glu  Glu Thr Leu 
    1025                 1030                 1035             


Thr Asn  Glu Thr Arg Asn Ala  Asp Asp Leu Glu Val  Ser Ser Asp 
    1040                 1045                 1050             


Ile Ile  Glu Ala Val Ala Ile  Ser Ser Asn Ser Phe  Ile Thr Thr 
    1055                 1060                 1065             


Gly Lys  Asp Ser Met Thr Val  Ser Glu Val Thr Ala  Ser Ile Ser 
    1070                 1075                 1080             


Ser Pro  Ser Glu Glu Asp Ala  Ser Glu Met Pro Glu  Phe Leu Asp 
    1085                 1090                 1095             


Lys Ser  Ile Val Glu Glu Glu  Glu Asp Asp Asp Tyr  Val Glu Leu 
    1100                 1105                 1110             


Lys Val  Glu Gly Ser Pro Thr  Glu Glu Ala Asn Leu  Pro Thr Glu 
    1115                 1120                 1125             


Leu Gln  Asp Asn Ser Leu Ser  Pro Ala Ala Ser Glu  Ala Gly Glu 
    1130                 1135                 1140             


Lys Leu  Asp Met Phe Gly Asn  Asp Asp Lys Leu Ile  Phe Gln Glu 
    1145                 1150                 1155             


Gly Lys  Pro Val Thr Glu Lys  Gln Thr Asp Thr Glu  Thr Gln Asp 
    1160                 1165                 1170             


Ser Lys  Asp Ser Gly Ile Gln  Thr Met Thr Ala Ser  Gly Ser Ser 
    1175                 1180                 1185             


Ala Met  Ser Pro Glu Thr Thr  Val Ser Gln Ile Ala  Val Glu Ser 
    1190                 1195                 1200             


Asp Leu  Gly Gln Met Leu Glu  Glu Gly Lys Lys Ala  Thr Asn Leu 
    1205                 1210                 1215             


Thr Arg  Glu Thr Lys Leu Ile  Asn Asp Cys His Gly  Ser Val Ser 
    1220                 1225                 1230             


Glu Ala  Ser Ser Glu Gln Lys  Ile Ala Lys Leu Asp  Val Ser Asn 
    1235                 1240                 1245             


Val Ala  Thr Asp Thr Glu Arg  Leu Glu Leu Lys Ala  Ser Pro Asn 
    1250                 1255                 1260             


Val Glu  Ala Pro Gln Pro His  Arg His Val Leu Glu  Ile Ser Arg 
    1265                 1270                 1275             


Gln His  Glu Gln Pro Gly Gln  Gly Ile Ala Pro Asp  Ala Val Asn 
    1280                 1285                 1290             


Gly Gln  Arg Arg Asp Ser Arg  Ser Thr Val Phe Arg  Ile Pro Glu 
    1295                 1300                 1305             


Phe Asn  Trp Ser Gln Met His  Gln Arg Leu Leu Thr  Asp Leu Leu 
    1310                 1315                 1320             


Phe Ser  Ile Glu Thr Asp Ile  Gln Met Trp Arg Ser  His Ser Thr 
    1325                 1330                 1335             


Lys Thr  Val Met Asp Phe Val  Asn Ser Ser Asp Asn  Val Ile Phe 
    1340                 1345                 1350             


Val His  Asn Thr Ile His Leu  Ile Ser Gln Val Met  Asp Asn Met 
    1355                 1360                 1365             


Val Met  Ala Cys Gly Gly Ile  Leu Pro Leu Leu Ser  Ala Ala Thr 
    1370                 1375                 1380             


Ser Ala  Thr His Glu Leu Glu  Asn Ile Glu Pro Thr  Gln Gly Leu 
    1385                 1390                 1395             


Ser Ile  Glu Ala Ser Val Thr  Phe Leu Gln Arg Leu  Ile Ser Leu 
    1400                 1405                 1410             


Val Asp  Val Leu Ile Phe Ala  Ser Ser Leu Gly Phe  Thr Glu Ile 
    1415                 1420                 1425             


Glu Ala  Glu Lys Ser Met Ser  Ser Gly Gly Ile Leu  Arg Gln Cys 
    1430                 1435                 1440             


Leu Arg  Leu Val Cys Ala Val  Ala Val Arg Asn Cys  Leu Glu Cys 
    1445                 1450                 1455             


Gln Gln  His Ser Gln Leu Lys  Thr Arg Gly Asp Lys  Ala Leu Lys 
    1460                 1465                 1470             


Pro Met  His Ser Leu Ile Pro  Leu Gly Lys Ser Ala  Ala Lys Ser 
    1475                 1480                 1485             


Pro Val  Asp Ile Val Thr Gly  Gly Ile Ser Pro Val  Arg Asp Leu 
    1490                 1495                 1500             


Asp Arg  Leu Leu Gln Asp Met  Asp Ile Asn Arg Leu  Arg Ala Val 
    1505                 1510                 1515             


Val Phe  Arg Asp Ile Glu Asp  Ser Lys Gln Ala Gln  Phe Leu Ala 
    1520                 1525                 1530             


Leu Ala  Val Val Tyr Phe Ile  Ser Val Leu Met Val  Ser Lys Tyr 
    1535                 1540                 1545             


Arg Asp  Ile Leu Glu Pro Gln  Asn Glu Arg His Ser  Gln Ser Cys 
    1550                 1555                 1560             


Thr Glu  Thr Gly Ser Glu Asn  Glu Asn Val Ser Leu  Ser Glu Ile 
    1565                 1570                 1575             


Thr Pro  Ala Ala Phe Ser Thr  Leu Thr Thr Ala Ser  Val Glu Glu 
    1580                 1585                 1590             


Ser Glu  Ser Thr Ser Ser Ala  Arg Arg Arg Asp Ser  Gly Ile Gly 
    1595                 1600                 1605             


Glu Glu  Thr Ala Thr Gly Leu  Gly Ser His Val Glu  Val Thr Pro 
    1610                 1615                 1620             


His Thr  Ala Pro Pro Gly Val  Ser Ala Gly Pro Asp  Ala Ile Ser 
    1625                 1630                 1635             


Glu Val  Leu Ser Thr Leu Ser  Leu Glu Val Asn Lys  Ser Pro Glu 
    1640                 1645                 1650             


Thr Lys  Asn Asp Arg Gly Asn  Asp Leu Asp Thr Lys  Ala Thr Pro 
    1655                 1660                 1665             


Ser Val  Ser Val Ser Lys Asn  Val Asn Val Lys Asp  Ile Leu Arg 
    1670                 1675                 1680             


Ser Leu  Val Asn Ile Pro Ala  Asp Gly Val Thr Val  Asp Pro Ala 
    1685                 1690                 1695             


Leu Leu  Pro Pro Ala Cys Leu  Gly Ala Leu Gly Asp  Leu Ser Val 
    1700                 1705                 1710             


Glu Gln  Pro Val Gln Phe Arg  Ser Phe Asp Arg Ser  Val Ile Val 
    1715                 1720                 1725             


Ala Ala  Lys Lys Ser Ala Val  Ser Pro Ser Thr Phe  Asn Thr Ser 
    1730                 1735                 1740             


Ile Pro  Thr Asn Ala Val Ser  Val Val Ser Ser Val  Asp Ser Ala 
    1745                 1750                 1755             


Gln Ala  Ser Asp Met Gly Gly  Glu Ser Pro Gly Ser  Arg Ser Ser 
    1760                 1765                 1770             


Asn Ala  Lys Leu Pro Ser Val  Pro Thr Val Asp Ser  Val Ser Gln 
    1775                 1780                 1785             


Asp Pro  Val Ser Asn Met Ser  Ile Thr Glu Arg Leu  Glu His Ala 
    1790                 1795                 1800             


Leu Glu  Lys Ala Ala Pro Leu  Leu Arg Glu Ile Phe  Val Asp Phe 
    1805                 1810                 1815             


Ala Pro  Phe Leu Ser Arg Thr  Leu Leu Gly Ser His  Gly Gln Glu 
    1820                 1825                 1830             


Leu Leu  Ile Glu Gly Thr Ser  Leu Val Cys Met Lys  Ser Ser Ser 
    1835                 1840                 1845             


Ser Val  Val Glu Leu Val Met  Leu Leu Cys Ser Gln  Glu Trp Gln 
    1850                 1855                 1860             


Asn Ser  Ile Gln Lys Asn Ala  Gly Leu Ala Phe Ile  Glu Leu Val 
    1865                 1870                 1875             


Asn Glu  Gly Arg Leu Leu Ser  Gln Thr Met Lys Asp  His Leu Val 
    1880                 1885                 1890             


Arg Val  Ala Asn Glu Ala Glu  Phe Ile Leu Ser Arg  Gln Arg Ala 
    1895                 1900                 1905             


Glu Asp  Ile His Arg His Ala  Glu Phe Glu Ser Leu  Cys Ala Gln 
    1910                 1915                 1920             


Tyr Ser  Ala Asp Lys Arg Glu  Asp Glu Lys Met Cys  Asp His Leu 
    1925                 1930                 1935             


Ile Arg  Ala Ala Lys Tyr Arg  Asp His Val Thr Ala  Thr Gln Leu 
    1940                 1945                 1950             


Ile Gln  Lys Ile Ile Asn Ile  Leu Thr Asp Lys His  Gly Ala Trp 
    1955                 1960                 1965             


Gly Asn  Ser Ala Val Ser Arg  Pro Leu Glu Phe Trp  Arg Leu Asp 
    1970                 1975                 1980             


Tyr Trp  Glu Asp Asp Leu Arg  Arg Arg Arg Arg Phe  Val Arg Asn 
    1985                 1990                 1995             


Pro Leu  Gly Ser Thr His Pro  Glu Ala Thr Leu Lys  Thr Ala Val 
    2000                 2005                 2010             


Glu His  Val Cys Ile Phe Lys  Leu Arg Glu Asn Ser  Lys Ala Thr 
    2015                 2020                 2025             


Asp Glu  Asp Ile Leu Ala Lys  Gly Lys Gln Ser Ile  Arg Ser Gln 
    2030                 2035                 2040             


Ala Leu  Gly Asn Gln Asn Ser  Glu Asn Glu Ile Leu  Leu Glu Gly 
    2045                 2050                 2055             


Asp Asp  Asp Thr Leu Ser Ser  Val Asp Glu Lys Asp  Leu Glu Asn 
    2060                 2065                 2070             


Leu Ala  Gly Pro Val Ser Leu  Ser Thr Pro Ala Gln  Leu Val Ala 
    2075                 2080                 2085             


Pro Ser  Val Val Val Lys Gly  Thr Leu Ser Val Thr  Ser Ser Glu 
    2090                 2095                 2100             


Leu Tyr  Phe Glu Val Asp Glu  Glu Asp Pro Asn Phe  Lys Lys Ile 
    2105                 2110                 2115             


Asp Pro  Lys Ile Leu Ala Tyr  Thr Glu Gly Leu His  Gly Lys Trp 
    2120                 2125                 2130             


Leu Phe  Thr Glu Ile Arg Ser  Ile Phe Ser Arg Arg  Tyr Leu Leu 
    2135                 2140                 2145             


Gln Asn  Thr Ala Leu Glu Ile  Phe Met Ala Asn Arg  Val Ala Val 
    2150                 2155                 2160             


Met Phe  Asn Phe Pro Asp Pro  Ala Thr Val Lys Lys  Val Val Asn 
    2165                 2170                 2175             


Tyr Leu  Pro Arg Val Gly Val  Gly Thr Ser Phe Gly  Leu Pro Gln 
    2180                 2185                 2190             


Thr Arg  Arg Ile Ser Leu Ala  Ser Pro Arg Gln Leu  Phe Lys Ala 
    2195                 2200                 2205             


Ser Asn  Met Thr Gln Arg Trp  Gln His Arg Glu Ile  Ser Asn Phe 
    2210                 2215                 2220             


Glu Tyr  Leu Met Phe Leu Asn  Thr Ile Ala Gly Arg  Ser Tyr Asn 
    2225                 2230                 2235             


Asp Leu  Asn Gln Tyr Pro Val  Phe Pro Trp Val Ile  Thr Asn Tyr 
    2240                 2245                 2250             


Glu Ser  Glu Glu Leu Asp Leu  Thr Leu Pro Thr Asn  Phe Arg Asp 
    2255                 2260                 2265             


Leu Ser  Lys Pro Ile Gly Ala  Leu Asn Pro Lys Arg  Ala Ala Phe 
    2270                 2275                 2280             


Phe Ala  Glu Arg Tyr Glu Ser  Trp Glu Asp Asp Gln  Val Pro Lys 
    2285                 2290                 2295             


Phe His  Tyr Gly Thr His Tyr  Ser Thr Ala Ser Phe  Val Leu Ala 
    2300                 2305                 2310             


Trp Leu  Leu Arg Ile Glu Pro  Phe Thr Thr Tyr Phe  Leu Asn Leu 
    2315                 2320                 2325             


Gln Gly  Gly Lys Phe Asp His  Ala Asp Arg Thr Phe  Ser Ser Ile 
    2330                 2335                 2340             


Ser Arg  Ala Trp Arg Asn Ser  Gln Arg Asp Thr Ser  Asp Ile Lys 
    2345                 2350                 2355             


Glu Leu  Ile Pro Glu Phe Tyr  Tyr Leu Pro Glu Met  Phe Val Asn 
    2360                 2365                 2370             


Phe Asn  Asn Tyr Asn Leu Gly  Val Met Asp Asp Gly  Thr Val Val 
    2375                 2380                 2385             


Ser Asp  Val Glu Leu Pro Pro  Trp Ala Lys Thr Ser  Glu Glu Phe 
    2390                 2395                 2400             


Val His  Ile Asn Arg Leu Ala  Leu Glu Ser Glu Phe  Val Ser Cys 
    2405                 2410                 2415             


Gln Leu  His Gln Trp Ile Asp  Leu Ile Phe Gly Tyr  Lys Gln Gln 
    2420                 2425                 2430             


Gly Pro  Glu Ala Val Arg Ala  Leu Asn Val Phe Tyr  Tyr Leu Thr 
    2435                 2440                 2445             


Tyr Glu  Gly Ala Val Asn Leu  Asn Ser Ile Thr Asp  Pro Val Leu 
    2450                 2455                 2460             


Arg Glu  Ala Val Glu Ala Gln  Ile Arg Ser Phe Gly  Gln Thr Pro 
    2465                 2470                 2475             


Ser Gln  Leu Leu Ile Glu Pro  His Pro Pro Arg Gly  Ser Ala Met 
    2480                 2485                 2490             


Gln Val  Ser Pro Leu Met Phe  Thr Asp Lys Ala Gln  Gln Asp Val 
    2495                 2500                 2505             


Ile Met  Val Leu Lys Phe Pro  Ser Asn Ser Pro Val  Thr His Val 
    2510                 2515                 2520             


Ala Ala  Asn Thr Gln Pro Gly  Leu Ala Thr Pro Ala  Val Ile Thr 
    2525                 2530                 2535             


Val Thr  Ala Asn Arg Leu Phe  Ala Val Asn Lys Trp  His Asn Leu 
    2540                 2545                 2550             


Pro Ala  His Gln Gly Ala Val  Gln Asp Gln Pro Tyr  Gln Leu Pro 
    2555                 2560                 2565             


Val Glu  Ile Asp Pro Leu Ile  Ala Ser Asn Thr Gly  Met His Arg 
    2570                 2575                 2580             


Arg Gln  Ile Thr Asp Leu Leu  Asp Gln Ser Ile Gln  Val His Ser 
    2585                 2590                 2595             


Gln Cys  Phe Val Ile Thr Ser  Asp Asn Arg Tyr Ile  Leu Val Cys 
    2600                 2605                 2610             


Gly Phe  Trp Asp Lys Ser Phe  Arg Val Tyr Ser Thr  Asp Thr Gly 
    2615                 2620                 2625             


Arg Leu  Ile Gln Val Val Phe  Gly His Trp Asp Val  Val Thr Cys 
    2630                 2635                 2640             


Leu Ala  Arg Ser Glu Ser Tyr  Ile Gly Gly Asn Cys  Tyr Ile Leu 
    2645                 2650                 2655             


Ser Gly  Ser Arg Asp Ala Thr  Leu Leu Leu Trp Tyr  Trp Asn Gly 
    2660                 2665                 2670             


Lys Cys  Ser Gly Ile Gly Asp  Asn Pro Gly Ser Glu  Thr Ala Ala 
    2675                 2680                 2685             


Pro Arg  Ala Ile Leu Thr Gly  His Asp Tyr Glu Val  Thr Cys Ala 
    2690                 2695                 2700             


Ala Val  Cys Ala Glu Leu Gly  Leu Val Leu Ser Gly  Ser Gln Glu 
    2705                 2710                 2715             


Gly Pro  Cys Leu Ile His Ser  Met Asn Gly Asp Leu  Leu Arg Thr 
    2720                 2725                 2730             


Leu Glu  Gly Pro Glu Asn Cys  Leu Lys Pro Lys Leu  Ile Gln Ala 
    2735                 2740                 2745             


Ser Arg  Glu Gly His Cys Val  Ile Phe Tyr Glu Asn  Gly Leu Phe 
    2750                 2755                 2760             


Cys Thr  Phe Ser Val Asn Gly  Lys Leu Gln Ala Thr  Met Glu Thr 
    2765                 2770                 2775             


Asp Asp  Asn Ile Arg Ala Ile  Gln Leu Ser Arg Asp  Gly Gln Tyr 
    2780                 2785                 2790             


Leu Leu  Thr Gly Gly Asp Arg  Gly Val Val Val Val  Arg Gln Val 
    2795                 2800                 2805             


Ser Asp  Leu Lys Gln Leu Phe  Ala Tyr Pro Gly Cys  Asp Ala Gly 
    2810                 2815                 2820             


Ile Arg  Ala Met Ala Leu Ser  Tyr Asp Gln Arg Cys  Ile Ile Ser 
    2825                 2830                 2835             


Gly Met  Ala Ser Gly Ser Ile  Val Leu Phe Tyr Asn  Asp Phe Asn 
    2840                 2845                 2850             


Arg Trp  His His Glu Tyr Gln  Thr Arg Tyr 
    2855                 2860             


<210>  185
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  185

Gly Phe Thr Glu Ile Glu Ala Glu Lys Ser Met Ser Ser Gly Gly Ile 
1               5                   10                  15      


Leu Arg Gln Cys Leu Arg Leu Val Cys Ala Val Ala Val Arg Asn Cys 
            20                  25                  30          


Leu Glu Cys Gln Gln His Ser Gln Leu Lys Thr Arg Gly Asp Lys Ala 
        35                  40                  45              


Leu Lys Pro Met His Ser Leu Ile Pro Leu Gly Lys Ser Ala Ala Lys 
    50                  55                  60                  


Ser Pro Val Asp Ile Val Thr Gly Gly Ile Ser Pro Val Arg Asp Leu 
65                  70                  75                  80  


Asp Arg Leu Leu Gln Asp Met Asp Ile Asn Arg Leu Arg Ala Val Val 
                85                  90                  95      


Phe Arg Asp Ile Thr Lys Lys Ser Leu His Met Asn Leu Gln Asn Ile 
            100                 105                 110         


Ile Asp Phe Val Arg Ser Arg Ile Thr Asn Met Ser Lys Asn Cys Ile 
        115                 120                 125             


Lys Trp Ile Cys Ser Asn 
    130                 


<210>  186
<211>  2575
<212>  PRT
<213>  Homo sapiens

<400>  186

Met Ala Ser Glu Asp Asn Arg Val Pro Ser Pro Pro Pro Thr Gly Asp 
1               5                   10                  15      


Asp Gly Gly Gly Gly Gly Arg Glu Glu Thr Pro Thr Glu Gly Gly Ala 
            20                  25                  30          


Leu Ser Leu Lys Pro Gly Leu Pro Ile Arg Gly Ile Arg Met Lys Phe 
        35                  40                  45              


Ala Val Leu Thr Gly Leu Val Glu Val Gly Glu Val Ser Asn Arg Asp 
    50                  55                  60                  


Ile Val Glu Thr Val Phe Asn Leu Leu Val Gly Gly Gln Phe Asp Leu 
65                  70                  75                  80  


Glu Met Asn Phe Ile Ile Gln Glu Gly Glu Ser Ile Asn Cys Met Val 
                85                  90                  95      


Asp Leu Leu Glu Lys Cys Asp Ile Thr Cys Gln Ala Glu Val Trp Ser 
            100                 105                 110         


Met Phe Thr Ala Ile Leu Lys Lys Ser Ile Arg Asn Leu Gln Val Cys 
        115                 120                 125             


Thr Glu Val Gly Leu Val Glu Lys Val Leu Gly Lys Ile Glu Lys Val 
    130                 135                 140                 


Asp Asn Met Ile Ala Asp Leu Leu Val Asp Met Leu Gly Val Leu Ala 
145                 150                 155                 160 


Ser Tyr Asn Leu Thr Val Arg Glu Leu Lys Leu Phe Phe Ser Lys Leu 
                165                 170                 175     


Gln Gly Asp Lys Gly Arg Trp Pro Pro His Ala Gly Lys Leu Leu Ser 
            180                 185                 190         


Val Leu Lys His Met Pro Gln Lys Tyr Gly Pro Asp Ala Phe Phe Asn 
        195                 200                 205             


Phe Pro Gly Lys Ser Ala Ala Ala Ile Ala Leu Pro Pro Ile Ala Lys 
    210                 215                 220                 


Trp Pro Tyr Gln Asn Gly Phe Thr Phe His Thr Trp Leu Arg Met Asp 
225                 230                 235                 240 


Pro Val Asn Asn Ile Asn Val Asp Lys Asp Lys Pro Tyr Leu Tyr Cys 
                245                 250                 255     


Phe Arg Thr Ser Lys Gly Leu Gly Tyr Ser Ala His Phe Val Gly Gly 
            260                 265                 270         


Cys Leu Ile Val Thr Ser Ile Lys Ser Lys Gly Lys Gly Phe Gln His 
        275                 280                 285             


Cys Val Lys Phe Asp Phe Lys Pro Gln Lys Trp Tyr Met Val Thr Ile 
    290                 295                 300                 


Val His Ile Tyr Asn Arg Trp Lys Asn Ser Glu Leu Arg Cys Tyr Val 
305                 310                 315                 320 


Asn Gly Glu Leu Ala Ser Tyr Gly Glu Ile Thr Trp Phe Val Asn Thr 
                325                 330                 335     


Ser Asp Thr Phe Asp Lys Cys Phe Leu Gly Ser Ser Glu Thr Ala Asp 
            340                 345                 350         


Ala Asn Arg Val Phe Cys Gly Gln Met Thr Ala Val Tyr Leu Phe Ser 
        355                 360                 365             


Glu Ala Leu Asn Ala Ala Gln Ile Phe Ala Ile Tyr Gln Leu Gly Leu 
    370                 375                 380                 


Gly Tyr Lys Gly Thr Phe Lys Phe Lys Ala Glu Ser Asp Leu Phe Leu 
385                 390                 395                 400 


Ala Glu His His Lys Leu Leu Leu Tyr Asp Gly Lys Leu Ser Ser Ala 
                405                 410                 415     


Ile Ala Phe Thr Tyr Asn Pro Arg Ala Thr Asp Ala Gln Leu Cys Leu 
            420                 425                 430         


Glu Ser Ser Pro Lys Asp Asn Pro Ser Ile Phe Val His Ser Pro His 
        435                 440                 445             


Ala Leu Met Leu Gln Asp Val Lys Ala Val Leu Thr His Ser Ile Gln 
    450                 455                 460                 


Ser Ala Met His Ser Ile Gly Gly Val Gln Val Leu Phe Pro Leu Phe 
465                 470                 475                 480 


Ala Gln Leu Asp Tyr Arg Gln Tyr Leu Ser Asp Glu Ile Asp Leu Thr 
                485                 490                 495     


Ile Cys Ser Thr Leu Leu Ala Phe Ile Met Glu Leu Leu Lys Asn Ser 
            500                 505                 510         


Ile Ala Met Gln Glu Gln Met Leu Ala Cys Lys Gly Phe Leu Val Ile 
        515                 520                 525             


Gly Tyr Ser Leu Glu Lys Ser Ser Lys Ser His Val Ser Arg Ala Val 
    530                 535                 540                 


Leu Glu Leu Cys Leu Ala Phe Ser Lys Tyr Leu Ser Asn Leu Gln Asn 
545                 550                 555                 560 


Gly Met Pro Leu Leu Lys Gln Leu Cys Asp His Val Leu Leu Asn Pro 
                565                 570                 575     


Ala Ile Trp Ile His Thr Pro Ala Lys Val Gln Leu Met Leu Tyr Thr 
            580                 585                 590         


Tyr Leu Ser Thr Glu Phe Ile Gly Thr Val Asn Ile Tyr Asn Thr Ile 
        595                 600                 605             


Arg Arg Val Gly Thr Val Leu Leu Ile Met His Thr Leu Lys Tyr Tyr 
    610                 615                 620                 


Tyr Trp Ala Val Asn Pro Gln Asp Arg Ser Gly Ile Thr Pro Lys Gly 
625                 630                 635                 640 


Leu Asp Gly Pro Arg Pro Asn Gln Lys Glu Met Leu Ser Leu Arg Ala 
                645                 650                 655     


Phe Leu Leu Met Phe Ile Lys Gln Leu Val Met Lys Asp Ser Gly Val 
            660                 665                 670         


Lys Glu Asp Glu Leu Gln Ala Ile Leu Asn Tyr Leu Leu Thr Met His 
        675                 680                 685             


Glu Asp Asp Asn Leu Met Asp Val Leu Gln Leu Leu Val Ala Leu Met 
    690                 695                 700                 


Ser Glu His Pro Asn Ser Met Ile Pro Ala Phe Asp Gln Arg Asn Gly 
705                 710                 715                 720 


Leu Arg Val Ile Tyr Lys Leu Leu Ala Ser Lys Ser Glu Gly Ile Arg 
                725                 730                 735     


Val Gln Ala Leu Lys Ala Met Gly Tyr Phe Leu Lys His Leu Ala Pro 
            740                 745                 750         


Lys Arg Lys Ala Glu Val Met Leu Gly His Gly Leu Phe Ser Leu Leu 
        755                 760                 765             


Ala Glu Arg Leu Met Leu Gln Thr Asn Leu Ile Thr Met Thr Thr Tyr 
    770                 775                 780                 


Asn Val Leu Phe Glu Ile Leu Ile Glu Gln Ile Gly Thr Gln Val Ile 
785                 790                 795                 800 


His Lys Gln His Pro Asp Pro Asp Ser Ser Val Lys Ile Gln Asn Pro 
                805                 810                 815     


Gln Ile Leu Lys Val Ile Ala Thr Leu Leu Arg Asn Ser Pro Gln Cys 
            820                 825                 830         


Pro Glu Ser Met Glu Val Arg Arg Ala Phe Leu Ser Asp Met Ile Lys 
        835                 840                 845             


Leu Phe Asn Asn Ser Arg Glu Asn Arg Arg Ser Leu Leu Gln Cys Ser 
    850                 855                 860                 


Val Trp Gln Glu Trp Met Leu Ser Leu Cys Tyr Phe Asn Pro Lys Asn 
865                 870                 875                 880 


Ser Asp Glu Gln Lys Ile Thr Glu Met Val Tyr Ala Ile Phe Arg Ile 
                885                 890                 895     


Leu Leu Tyr His Ala Val Lys Tyr Glu Trp Gly Gly Trp Arg Val Trp 
            900                 905                 910         


Val Asp Thr Leu Ser Ile Thr His Ser Lys Val Thr Phe Glu Ile His 
        915                 920                 925             


Lys Glu Asn Leu Ala Asn Ile Phe Arg Glu Gln Gln Gly Lys Val Asp 
    930                 935                 940                 


Glu Glu Ile Gly Leu Cys Ser Ser Thr Ser Val Gln Ala Ala Ser Gly 
945                 950                 955                 960 


Ile Arg Arg Asp Ile Asn Val Ser Val Gly Ser Gln Gln Pro Asp Thr 
                965                 970                 975     


Lys Asp Ser Pro Val Cys Pro His Phe Thr Thr Asn Gly Asn Glu Asn 
            980                 985                 990         


Ser Ser Ile Glu Lys Thr Ser Ser  Leu Glu Ser Ala Ser  Asn Ile Glu 
        995                 1000                 1005             


Leu Gln  Thr Thr Asn Thr Ser  Tyr Glu Glu Met Lys  Ala Glu Gln 
    1010                 1015                 1020             


Glu Asn  Gln Glu Leu Pro Asp  Glu Gly Thr Leu Glu  Glu Thr Leu 
    1025                 1030                 1035             


Thr Asn  Glu Thr Arg Asn Ala  Asp Asp Leu Glu Val  Ser Ser Asp 
    1040                 1045                 1050             


Ile Ile  Glu Ala Val Ala Ile  Ser Ser Asn Ser Phe  Ile Thr Thr 
    1055                 1060                 1065             


Gly Lys  Asp Ser Met Thr Val  Ser Glu Val Thr Ala  Ser Ile Ser 
    1070                 1075                 1080             


Ser Pro  Ser Glu Glu Asp Ala  Ser Glu Met Pro Glu  Phe Leu Asp 
    1085                 1090                 1095             


Lys Ser  Ile Val Glu Glu Glu  Glu Asp Asp Asp Tyr  Val Glu Leu 
    1100                 1105                 1110             


Lys Val  Glu Gly Ser Pro Thr  Glu Glu Ala Asn Leu  Pro Thr Glu 
    1115                 1120                 1125             


Leu Gln  Asp Asn Ser Leu Ser  Pro Ala Ala Ser Glu  Ala Gly Glu 
    1130                 1135                 1140             


Lys Leu  Asp Met Phe Gly Asn  Asp Asp Lys Leu Ile  Phe Gln Glu 
    1145                 1150                 1155             


Gly Lys  Pro Val Thr Glu Lys  Gln Thr Asp Thr Glu  Thr Gln Asp 
    1160                 1165                 1170             


Ser Lys  Asp Ser Gly Ile Gln  Thr Met Thr Ala Ser  Gly Ser Ser 
    1175                 1180                 1185             


Ala Met  Ser Pro Glu Thr Thr  Val Ser Gln Ile Ala  Val Glu Ser 
    1190                 1195                 1200             


Asp Leu  Gly Gln Met Leu Glu  Glu Gly Lys Lys Ala  Thr Asn Leu 
    1205                 1210                 1215             


Thr Arg  Glu Thr Lys Leu Ile  Asn Asp Cys His Gly  Ser Val Ser 
    1220                 1225                 1230             


Glu Ala  Ser Ser Glu Gln Lys  Ile Ala Lys Leu Asp  Val Ser Asn 
    1235                 1240                 1245             


Val Ala  Thr Asp Thr Glu Arg  Leu Glu Leu Lys Ala  Ser Pro Asn 
    1250                 1255                 1260             


Val Glu  Ala Pro Gln Pro His  Arg His Val Leu Glu  Ile Ser Arg 
    1265                 1270                 1275             


Gln His  Glu Gln Pro Gly Gln  Gly Ile Ala Pro Asp  Ala Val Asn 
    1280                 1285                 1290             


Gly Gln  Arg Arg Asp Ser Arg  Ser Thr Val Phe Arg  Ile Pro Glu 
    1295                 1300                 1305             


Phe Asn  Trp Ser Gln Met His  Gln Arg Leu Leu Thr  Asp Leu Leu 
    1310                 1315                 1320             


Phe Ser  Ile Glu Thr Asp Ile  Gln Met Trp Arg Ser  His Ser Thr 
    1325                 1330                 1335             


Lys Thr  Val Met Asp Phe Val  Asn Ser Ser Asp Asn  Val Ile Phe 
    1340                 1345                 1350             


Val His  Asn Thr Ile His Leu  Ile Ser Gln Val Met  Asp Asn Met 
    1355                 1360                 1365             


Val Met  Ala Cys Gly Gly Ile  Leu Pro Leu Leu Ser  Ala Ala Thr 
    1370                 1375                 1380             


Ser Ala  Thr His Glu Leu Glu  Asn Ile Glu Pro Thr  Gln Gly Leu 
    1385                 1390                 1395             


Ser Ile  Glu Ala Ser Val Thr  Phe Leu Gln Arg Leu  Ile Ser Leu 
    1400                 1405                 1410             


Val Asp  Val Leu Ile Phe Ala  Ser Ser Leu Gly Phe  Thr Glu Ile 
    1415                 1420                 1425             


Glu Ala  Glu Lys Ser Met Ser  Ser Gly Gly Ile Leu  Arg Gln Cys 
    1430                 1435                 1440             


Leu Arg  Leu Val Cys Ala Val  Ala Val Arg Asn Cys  Leu Glu Cys 
    1445                 1450                 1455             


Gln Gln  His Ser Gln Leu Lys  Thr Arg Gly Asp Lys  Ala Leu Lys 
    1460                 1465                 1470             


Pro Met  His Ser Leu Ile Pro  Leu Gly Lys Ser Ala  Ala Lys Ser 
    1475                 1480                 1485             


Pro Val  Asp Ile Val Thr Gly  Gly Ile Ser Pro Val  Arg Asp Leu 
    1490                 1495                 1500             


Asp Arg  Leu Leu Gln Asp Met  Asp Ile Asn Arg Leu  Arg Ala Val 
    1505                 1510                 1515             


Val Phe  Arg Asp Ile Glu Asp  Ser Lys Gln Ala Gln  Phe Leu Ala 
    1520                 1525                 1530             


Leu Ala  Val Val Tyr Phe Ile  Ser Val Leu Met Val  Ser Lys Tyr 
    1535                 1540                 1545             


Arg Asp  Ile Leu Glu Pro Gln  Asn Glu Arg His Ser  Gln Ser Cys 
    1550                 1555                 1560             


Thr Glu  Thr Gly Ser Glu Asn  Glu Asn Val Ser Leu  Ser Glu Ile 
    1565                 1570                 1575             


Thr Pro  Ala Ala Phe Ser Thr  Leu Thr Thr Ala Ser  Val Glu Glu 
    1580                 1585                 1590             


Ser Glu  Ser Thr Ser Ser Ala  Arg Arg Arg Asp Ser  Gly Ile Gly 
    1595                 1600                 1605             


Glu Glu  Thr Ala Thr Gly Leu  Gly Ser His Val Glu  Val Thr Pro 
    1610                 1615                 1620             


His Thr  Ala Pro Pro Gly Val  Ser Ala Gly Pro Asp  Ala Ile Ser 
    1625                 1630                 1635             


Glu Val  Leu Ser Thr Leu Ser  Leu Glu Val Asn Lys  Ser Pro Glu 
    1640                 1645                 1650             


Thr Lys  Asn Asp Arg Gly Asn  Asp Leu Asp Thr Lys  Ala Thr Pro 
    1655                 1660                 1665             


Ser Val  Ser Val Ser Lys Asn  Val Asn Val Lys Asp  Ile Leu Arg 
    1670                 1675                 1680             


Ser Leu  Val Asn Ile Pro Ala  Asp Gly Val Thr Val  Asp Pro Ala 
    1685                 1690                 1695             


Leu Leu  Pro Pro Ala Cys Leu  Gly Ala Leu Gly Asp  Leu Ser Val 
    1700                 1705                 1710             


Glu Gln  Pro Val Gln Phe Arg  Ser Phe Asp Arg Ser  Val Ile Val 
    1715                 1720                 1725             


Ala Ala  Lys Lys Ser Ala Val  Ser Pro Ser Thr Phe  Asn Thr Ser 
    1730                 1735                 1740             


Ile Pro  Thr Asn Ala Val Ser  Val Val Ser Ser Val  Asp Ser Ala 
    1745                 1750                 1755             


Gln Ala  Ser Asp Met Gly Gly  Glu Ser Pro Gly Ser  Arg Ser Ser 
    1760                 1765                 1770             


Asn Ala  Lys Leu Pro Ser Val  Pro Thr Val Asp Ser  Val Ser Gln 
    1775                 1780                 1785             


Asp Pro  Val Ser Asn Met Ser  Ile Thr Glu Arg Leu  Glu His Ala 
    1790                 1795                 1800             


Leu Glu  Lys Ala Ala Pro Leu  Leu Arg Glu Ile Phe  Val Asp Phe 
    1805                 1810                 1815             


Ala Pro  Phe Leu Ser Arg Thr  Leu Leu Gly Ser His  Gly Gln Glu 
    1820                 1825                 1830             


Leu Leu  Ile Glu Gly Thr Ser  Leu Val Cys Met Lys  Ser Ser Ser 
    1835                 1840                 1845             


Ser Val  Val Glu Leu Val Met  Leu Leu Cys Ser Gln  Glu Trp Gln 
    1850                 1855                 1860             


Asn Ser  Ile Gln Lys Asn Ala  Gly Leu Ala Phe Ile  Glu Leu Val 
    1865                 1870                 1875             


Asn Glu  Gly Arg Leu Leu Ser  Gln Thr Met Lys Asp  His Leu Val 
    1880                 1885                 1890             


Arg Val  Ala Asn Glu Ala Glu  Phe Ile Leu Ser Arg  Gln Arg Ala 
    1895                 1900                 1905             


Glu Asp  Ile His Arg His Ala  Glu Phe Glu Ser Leu  Cys Ala Gln 
    1910                 1915                 1920             


Tyr Ser  Ala Asp Lys Arg Glu  Asp Glu Lys Met Cys  Asp His Leu 
    1925                 1930                 1935             


Ile Arg  Ala Ala Lys Tyr Arg  Asp His Val Thr Ala  Thr Gln Leu 
    1940                 1945                 1950             


Ile Gln  Lys Ile Ile Asn Ile  Leu Thr Asp Lys His  Gly Ala Trp 
    1955                 1960                 1965             


Gly Asn  Ser Ala Val Ser Arg  Pro Leu Glu Phe Trp  Arg Leu Asp 
    1970                 1975                 1980             


Tyr Trp  Glu Asp Asp Leu Arg  Arg Arg Arg Arg Phe  Val Arg Asn 
    1985                 1990                 1995             


Pro Leu  Gly Ser Thr His Pro  Glu Ala Thr Leu Lys  Thr Ala Val 
    2000                 2005                 2010             


Glu His  Ala Thr Asp Glu Asp  Ile Leu Ala Lys Gly  Lys Gln Ser 
    2015                 2020                 2025             


Ile Arg  Ser Gln Ala Leu Gly  Asn Gln Asn Ser Glu  Asn Glu Ile 
    2030                 2035                 2040             


Leu Leu  Glu Gly Asp Asp Asp  Thr Leu Ser Ser Val  Asp Glu Lys 
    2045                 2050                 2055             


Asp Leu  Glu Asn Leu Ala Gly  Pro Val Ser Leu Ser  Thr Pro Ala 
    2060                 2065                 2070             


Gln Leu  Val Ala Pro Ser Val  Val Val Lys Gly Thr  Leu Ser Val 
    2075                 2080                 2085             


Thr Ser  Ser Glu Leu Tyr Phe  Glu Val Asp Glu Glu  Asp Pro Asn 
    2090                 2095                 2100             


Phe Lys  Lys Ile Asp Pro Lys  Ile Leu Ala Tyr Thr  Glu Gly Leu 
    2105                 2110                 2115             


His Gly  Lys Trp Leu Phe Thr  Glu Ile Arg Ser Ile  Phe Ser Arg 
    2120                 2125                 2130             


Arg Tyr  Leu Leu Gln Asn Thr  Ala Leu Glu Ile Phe  Met Ala Asn 
    2135                 2140                 2145             


Arg Val  Ala Val Met Phe Asn  Phe Pro Asp Pro Ala  Thr Val Lys 
    2150                 2155                 2160             


Lys Val  Val Asn Tyr Leu Pro  Arg Val Gly Val Gly  Thr Ser Phe 
    2165                 2170                 2175             


Gly Leu  Pro Gln Thr Arg Arg  Ile Ser Leu Ala Ser  Pro Arg Gln 
    2180                 2185                 2190             


Leu Phe  Lys Ala Ser Asn Met  Thr Gln Arg Trp Gln  His Arg Glu 
    2195                 2200                 2205             


Ile Ser  Asn Phe Glu Tyr Leu  Met Phe Leu Asn Thr  Ile Ala Gly 
    2210                 2215                 2220             


Arg Ser  Tyr Asn Asp Leu Asn  Gln Tyr Pro Val Phe  Pro Trp Val 
    2225                 2230                 2235             


Ile Thr  Asn Tyr Glu Ser Glu  Glu Leu Asp Leu Thr  Leu Pro Thr 
    2240                 2245                 2250             


Asn Phe  Arg Asp Leu Ser Lys  Pro Ile Gly Ala Leu  Asn Pro Lys 
    2255                 2260                 2265             


Arg Ala  Ala Phe Phe Ala Glu  Arg Tyr Glu Ser Trp  Glu Asp Asp 
    2270                 2275                 2280             


Gln Val  Pro Lys Phe His Tyr  Gly Thr His Tyr Ser  Thr Ala Ser 
    2285                 2290                 2295             


Phe Val  Leu Ala Trp Leu Leu  Arg Ile Glu Pro Phe  Thr Thr Tyr 
    2300                 2305                 2310             


Phe Leu  Asn Leu Gln Gly Gly  Lys Phe Asp His Ala  Asp Arg Thr 
    2315                 2320                 2325             


Phe Ser  Ser Ile Ser Arg Ala  Trp Arg Asn Ser Gln  Arg Asp Thr 
    2330                 2335                 2340             


Ser Asp  Ile Lys Glu Leu Ile  Pro Glu Phe Tyr Tyr  Leu Pro Glu 
    2345                 2350                 2355             


Met Phe  Val Asn Phe Asn Asn  Tyr Asn Leu Gly Val  Met Asp Asp 
    2360                 2365                 2370             


Gly Thr  Val Val Ser Asp Val  Glu Leu Pro Pro Trp  Ala Lys Thr 
    2375                 2380                 2385             


Ser Glu  Glu Phe Val His Ile  Asn Arg Leu Ala Leu  Glu Ser Glu 
    2390                 2395                 2400             


Phe Val  Ser Cys Gln Leu His  Gln Trp Ile Asp Leu  Ile Phe Gly 
    2405                 2410                 2415             


Tyr Lys  Gln Gln Gly Pro Glu  Ala Val Arg Ala Leu  Asn Val Phe 
    2420                 2425                 2430             


Tyr Tyr  Leu Thr Tyr Glu Gly  Ala Val Asn Leu Asn  Ser Ile Thr 
    2435                 2440                 2445             


Asp Pro  Val Leu Arg Glu Ala  Val Glu Ala Gln Ile  Arg Ser Phe 
    2450                 2455                 2460             


Gly Gln  Thr Pro Ser Gln Leu  Leu Ile Glu Pro His  Pro Pro Arg 
    2465                 2470                 2475             


Gly Ser  Ala Met Gln Val Ser  Pro Leu Met Phe Thr  Asp Lys Ala 
    2480                 2485                 2490             


Gln Gln  Asp Val Ile Met Val  Leu Lys Phe Pro Ser  Asn Ser Pro 
    2495                 2500                 2505             


Val Thr  His Val Ala Ala Asn  Thr Gln Pro Gly Leu  Ala Thr Pro 
    2510                 2515                 2520             


Ala Val  Ile Thr Val Thr Ala  Asn Arg Leu Phe Ala  Val Asn Lys 
    2525                 2530                 2535             


Trp His  Asn Leu Pro Ala His  Gln Gly Ala Val Gln  Asp Gln Pro 
    2540                 2545                 2550             


Tyr Gln  Leu Pro Val Glu Ile  Asp Pro Leu Ile Gly  Leu Ser Leu 
    2555                 2560                 2565             


Pro Ser  Leu Phe Ala Ile His  
    2570                 2575 


<210>  187
<211>  147
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  187

Xaa Tyr Ile Leu Ser Gly Ser Arg Asp Ala Thr Leu Leu Leu Trp Tyr 
1               5                   10                  15      


Trp Asn Gly Lys Cys Ser Gly Ile Gly Asp Asn Pro Gly Ser Glu Thr 
            20                  25                  30          


Ala Ala Pro Arg Ala Ile Leu Thr Gly His Asp Tyr Glu Val Thr Cys 
        35                  40                  45              


Ala Ala Val Cys Ala Glu Leu Gly Leu Val Leu Ser Gly Ser Gln Glu 
    50                  55                  60                  


Gly Pro Cys Leu Ile His Ser Met Asn Gly Asp Leu Leu Arg Thr Leu 
65                  70                  75                  80  


Glu Gly Pro Glu Asn Cys Leu Lys Pro Lys Leu Ile Gln Ala Ser Arg 
                85                  90                  95      


Glu Gly His Cys Val Ile Phe Tyr Glu Asn Gly Leu Phe Cys Thr Phe 
            100                 105                 110         


Ser Val Asn Gly Lys Leu Gln Ala Thr Met Glu Thr Asp Asp Asn Ile 
        115                 120                 125             


Arg Val His His Phe Trp His Gly Phe Arg Lys His Cys Ala Ile Leu 
    130                 135                 140                 


Gln Arg Leu 
145         


<210>  188
<211>  1505
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  188

Xaa Asp Asn Val Ile Phe Val His Asn Thr Ile His Leu Ile Ser Gln 
1               5                   10                  15      


Val Met Asp Asn Met Val Met Ala Cys Gly Gly Ile Leu Pro Leu Leu 
            20                  25                  30          


Ser Ala Ala Thr Ser Ala Thr His Glu Leu Glu Asn Ile Glu Pro Thr 
        35                  40                  45              


Gln Gly Leu Ser Ile Glu Ala Ser Val Thr Phe Leu Gln Arg Leu Ile 
    50                  55                  60                  


Ser Leu Val Asp Val Leu Ile Phe Ala Ser Ser Leu Gly Phe Thr Glu 
65                  70                  75                  80  


Ile Glu Ala Glu Lys Ser Met Ser Ser Gly Gly Ile Leu Arg Gln Cys 
                85                  90                  95      


Leu Arg Leu Val Cys Ala Val Ala Val Arg Asn Cys Leu Glu Cys Gln 
            100                 105                 110         


Gln His Ser Gln Leu Lys Thr Arg Gly Asp Lys Ala Leu Lys Pro Met 
        115                 120                 125             


His Ser Leu Ile Pro Leu Gly Lys Ser Ala Ala Lys Ser Pro Val Asp 
    130                 135                 140                 


Ile Val Thr Gly Gly Ile Ser Pro Val Arg Asp Leu Asp Arg Leu Leu 
145                 150                 155                 160 


Gln Asp Met Asp Ile Asn Arg Leu Arg Ala Val Val Phe Arg Asp Ile 
                165                 170                 175     


Glu Asp Ser Lys Gln Ala Gln Phe Leu Ala Leu Ala Val Val Tyr Phe 
            180                 185                 190         


Ile Ser Val Leu Met Val Ser Lys Tyr Arg Asp Ile Leu Glu Pro Gln 
        195                 200                 205             


Asn Glu Arg His Ser Gln Ser Cys Thr Glu Thr Gly Ser Glu Asn Glu 
    210                 215                 220                 


Asn Val Ser Leu Ser Glu Ile Thr Pro Ala Ala Phe Ser Thr Leu Thr 
225                 230                 235                 240 


Thr Ala Ser Val Glu Glu Ser Glu Ser Thr Ser Ser Ala Arg Arg Arg 
                245                 250                 255     


Asp Ser Gly Ile Gly Glu Glu Thr Ala Thr Gly Leu Gly Ser His Val 
            260                 265                 270         


Glu Val Thr Pro His Thr Ala Pro Pro Gly Val Ser Ala Gly Pro Asp 
        275                 280                 285             


Ala Ile Ser Glu Val Leu Ser Thr Leu Ser Leu Glu Val Asn Lys Ser 
    290                 295                 300                 


Pro Glu Thr Lys Asn Asp Arg Gly Asn Asp Leu Asp Thr Lys Ala Thr 
305                 310                 315                 320 


Pro Ser Val Ser Val Ser Lys Asn Val Asn Val Lys Asp Ile Leu Arg 
                325                 330                 335     


Ser Leu Val Asn Ile Pro Ala Asp Gly Val Thr Val Asp Pro Ala Leu 
            340                 345                 350         


Leu Pro Pro Ala Cys Leu Gly Ala Leu Gly Asp Leu Ser Val Glu Gln 
        355                 360                 365             


Pro Val Gln Phe Arg Ser Phe Asp Arg Ser Val Ile Val Ala Ala Lys 
    370                 375                 380                 


Lys Ser Ala Val Ser Pro Ser Thr Phe Asn Thr Ser Ile Pro Thr Asn 
385                 390                 395                 400 


Ala Val Ser Val Val Ser Ser Val Asp Ser Ala Gln Ala Ser Asp Met 
                405                 410                 415     


Gly Gly Glu Ser Pro Gly Ser Arg Ser Ser Asn Ala Lys Leu Pro Ser 
            420                 425                 430         


Val Pro Thr Val Asp Ser Val Ser Gln Asp Pro Val Ser Asn Met Ser 
        435                 440                 445             


Ile Thr Glu Arg Leu Glu His Ala Leu Glu Lys Ala Ala Pro Leu Leu 
    450                 455                 460                 


Arg Glu Ile Phe Val Asp Phe Ala Pro Phe Leu Ser Arg Thr Leu Leu 
465                 470                 475                 480 


Gly Ser His Gly Gln Glu Leu Leu Ile Glu Gly Thr Ser Leu Val Cys 
                485                 490                 495     


Met Lys Ser Ser Ser Ser Val Val Glu Leu Val Met Leu Leu Cys Ser 
            500                 505                 510         


Gln Glu Trp Gln Asn Ser Ile Gln Lys Asn Ala Gly Leu Ala Phe Ile 
        515                 520                 525             


Glu Leu Val Asn Glu Gly Arg Leu Leu Ser Gln Thr Met Lys Asp His 
    530                 535                 540                 


Leu Val Arg Val Ala Asn Glu Ala Glu Phe Ile Leu Ser Arg Gln Arg 
545                 550                 555                 560 


Ala Glu Asp Ile His Arg His Ala Glu Phe Glu Ser Leu Cys Ala Gln 
                565                 570                 575     


Tyr Ser Ala Asp Lys Arg Glu Asp Glu Lys Met Cys Asp His Leu Ile 
            580                 585                 590         


Arg Ala Ala Lys Tyr Arg Asp His Val Thr Ala Thr Gln Leu Ile Gln 
        595                 600                 605             


Lys Ile Ile Asn Ile Leu Thr Asp Lys His Gly Ala Trp Gly Asn Ser 
    610                 615                 620                 


Ala Val Ser Arg Pro Leu Glu Phe Trp Arg Leu Asp Tyr Trp Glu Asp 
625                 630                 635                 640 


Asp Leu Arg Arg Arg Arg Arg Phe Val Arg Asn Pro Leu Gly Ser Thr 
                645                 650                 655     


His Pro Glu Ala Thr Leu Lys Thr Ala Val Glu His Ala Thr Asp Glu 
            660                 665                 670         


Asp Ile Leu Ala Lys Gly Lys Gln Ser Ile Arg Ser Gln Ala Leu Gly 
        675                 680                 685             


Asn Gln Asn Ser Glu Asn Glu Ile Leu Leu Glu Gly Asp Asp Asp Thr 
    690                 695                 700                 


Leu Ser Ser Val Asp Glu Lys Asp Leu Glu Asn Leu Ala Gly Pro Val 
705                 710                 715                 720 


Ser Leu Ser Thr Pro Ala Gln Leu Val Ala Pro Ser Val Val Val Lys 
                725                 730                 735     


Gly Thr Leu Ser Val Thr Ser Ser Glu Leu Tyr Phe Glu Val Asp Glu 
            740                 745                 750         


Glu Asp Pro Asn Phe Lys Lys Ile Asp Pro Lys Ile Leu Ala Tyr Thr 
        755                 760                 765             


Glu Gly Leu His Gly Lys Trp Leu Phe Thr Glu Ile Arg Ser Ile Phe 
    770                 775                 780                 


Ser Arg Arg Tyr Leu Leu Gln Asn Thr Ala Leu Glu Ile Phe Met Ala 
785                 790                 795                 800 


Asn Arg Val Ala Val Met Phe Asn Phe Pro Asp Pro Ala Thr Val Lys 
                805                 810                 815     


Lys Val Val Asn Tyr Leu Pro Arg Val Gly Val Gly Thr Ser Phe Gly 
            820                 825                 830         


Leu Pro Gln Thr Arg Arg Ile Ser Leu Ala Ser Pro Arg Gln Leu Phe 
        835                 840                 845             


Lys Ala Ser Asn Met Thr Gln Arg Trp Gln His Arg Glu Ile Ser Asn 
    850                 855                 860                 


Phe Glu Tyr Leu Met Phe Leu Asn Thr Ile Ala Gly Arg Ser Tyr Asn 
865                 870                 875                 880 


Asp Leu Asn Gln Tyr Pro Val Phe Pro Trp Val Ile Thr Asn Tyr Glu 
                885                 890                 895     


Ser Glu Glu Leu Asp Leu Thr Leu Pro Thr Asn Phe Arg Asp Leu Ser 
            900                 905                 910         


Lys Pro Ile Gly Ala Leu Asn Pro Lys Arg Ala Ala Phe Phe Ala Glu 
        915                 920                 925             


Arg Tyr Glu Ser Trp Glu Asp Asp Gln Val Pro Lys Phe His Tyr Gly 
    930                 935                 940                 


Thr His Tyr Ser Thr Ala Ser Phe Val Leu Ala Trp Leu Leu Arg Ile 
945                 950                 955                 960 


Glu Pro Phe Thr Thr Tyr Phe Leu Asn Leu Gln Gly Gly Lys Phe Asp 
                965                 970                 975     


His Ala Asp Arg Thr Phe Ser Ser Ile Ser Arg Ala Trp Arg Asn Ser 
            980                 985                 990         


Gln Arg Asp Thr Ser Asp Ile Lys  Glu Leu Ile Pro Glu  Phe Tyr Tyr 
        995                 1000                 1005             


Leu Pro  Glu Met Phe Val Asn  Phe Asn Asn Tyr Asn  Leu Gly Val 
    1010                 1015                 1020             


Met Asp  Asp Gly Thr Val Val  Ser Asp Val Glu Leu  Pro Pro Trp 
    1025                 1030                 1035             


Ala Lys  Thr Ser Glu Glu Phe  Val His Ile Asn Arg  Leu Ala Leu 
    1040                 1045                 1050             


Glu Ser  Glu Phe Val Ser Cys  Gln Leu His Gln Trp  Ile Asp Leu 
    1055                 1060                 1065             


Ile Phe  Gly Tyr Lys Gln Gln  Gly Pro Glu Ala Val  Arg Ala Leu 
    1070                 1075                 1080             


Asn Val  Phe Tyr Tyr Leu Thr  Tyr Glu Gly Ala Val  Asn Leu Asn 
    1085                 1090                 1095             


Ser Ile  Thr Asp Pro Val Leu  Arg Glu Ala Val Glu  Ala Gln Ile 
    1100                 1105                 1110             


Arg Ser  Phe Gly Gln Thr Pro  Ser Gln Leu Leu Ile  Glu Pro His 
    1115                 1120                 1125             


Pro Pro  Arg Gly Ser Ala Met  Gln Val Ser Pro Leu  Met Phe Thr 
    1130                 1135                 1140             


Asp Lys  Ala Gln Gln Asp Val  Ile Met Val Leu Lys  Phe Pro Ser 
    1145                 1150                 1155             


Asn Ser  Pro Val Thr His Val  Ala Ala Asn Thr Gln  Pro Gly Leu 
    1160                 1165                 1170             


Ala Thr  Pro Ala Val Ile Thr  Val Thr Ala Asn Arg  Leu Phe Ala 
    1175                 1180                 1185             


Val Asn  Lys Trp His Asn Leu  Pro Ala His Gln Gly  Ala Val Gln 
    1190                 1195                 1200             


Asp Gln  Pro Tyr Gln Leu Pro  Val Glu Ile Asp Pro  Leu Ile Ala 
    1205                 1210                 1215             


Ser Asn  Thr Gly Met His Arg  Arg Gln Ile Thr Asp  Leu Leu Asp 
    1220                 1225                 1230             


Gln Ser  Ile Gln Val His Ser  Gln Cys Phe Val Ile  Thr Ser Asp 
    1235                 1240                 1245             


Asn Arg  Tyr Ile Leu Val Cys  Gly Phe Trp Asp Lys  Ser Phe Arg 
    1250                 1255                 1260             


Val Tyr  Ser Thr Asp Thr Gly  Arg Leu Ile Gln Val  Val Phe Gly 
    1265                 1270                 1275             


His Trp  Asp Val Val Thr Cys  Leu Ala Arg Ser Glu  Ser Tyr Ile 
    1280                 1285                 1290             


Gly Gly  Asn Cys Tyr Ile Leu  Ser Gly Ser Arg Asp  Ala Thr Leu 
    1295                 1300                 1305             


Leu Leu  Trp Tyr Trp Asn Gly  Lys Cys Ser Gly Ile  Gly Asp Asn 
    1310                 1315                 1320             


Pro Gly  Ser Glu Thr Ala Ala  Pro Arg Ala Ile Leu  Thr Gly His 
    1325                 1330                 1335             


Asp Tyr  Glu Val Thr Cys Ala  Ala Val Cys Ala Glu  Leu Gly Leu 
    1340                 1345                 1350             


Val Leu  Ser Gly Ser Gln Glu  Gly Pro Cys Leu Ile  His Ser Met 
    1355                 1360                 1365             


Asn Gly  Asp Leu Leu Arg Thr  Leu Glu Gly Pro Glu  Asn Cys Leu 
    1370                 1375                 1380             


Lys Pro  Lys Leu Ile Gln Ala  Ser Arg Glu Gly His  Cys Val Ile 
    1385                 1390                 1395             


Phe Tyr  Glu Asn Gly Leu Phe  Cys Thr Phe Ser Val  Asn Gly Lys 
    1400                 1405                 1410             


Leu Gln  Ala Thr Met Glu Thr  Asp Asp Asn Ile Arg  Ala Ile Gln 
    1415                 1420                 1425             


Leu Ser  Arg Asp Gly Gln Tyr  Leu Leu Thr Gly Gly  Asp Arg Gly 
    1430                 1435                 1440             


Val Val  Val Val Arg Gln Val  Ser Asp Leu Lys Gln  Leu Phe Ala 
    1445                 1450                 1455             


Tyr Pro  Gly Cys Asp Ala Gly  Ile Arg Ala Met Ala  Leu Ser Tyr 
    1460                 1465                 1470             


Asp Gln  Arg Cys Ile Ile Ser  Gly Met Ala Ser Gly  Ser Ile Val 
    1475                 1480                 1485             


Leu Phe  Tyr Asn Asp Phe Asn  Arg Trp His His Glu  Tyr Gln Thr 
    1490                 1495                 1500             


Arg Tyr  
    1505 


<210>  189
<211>  1880
<212>  PRT
<213>  Homo sapiens

<400>  189

Met Ala Ser Glu Asp Asn Arg Val Pro Ser Pro Pro Pro Thr Gly Asp 
1               5                   10                  15      


Asp Gly Gly Gly Gly Gly Arg Glu Glu Thr Pro Thr Glu Gly Gly Ala 
            20                  25                  30          


Leu Ser Leu Lys Pro Gly Leu Pro Ile Arg Gly Ile Arg Met Lys Phe 
        35                  40                  45              


Ala Val Leu Thr Gly Leu Val Glu Val Gly Glu Val Ser Asn Arg Asp 
    50                  55                  60                  


Ile Val Glu Thr Val Phe Asn Leu Leu Val Gly Gly Gln Phe Asp Leu 
65                  70                  75                  80  


Glu Met Asn Phe Ile Ile Gln Glu Gly Glu Ser Ile Asn Cys Met Val 
                85                  90                  95      


Asp Leu Leu Glu Lys Cys Asp Ile Thr Cys Gln Ala Glu Val Trp Ser 
            100                 105                 110         


Met Phe Thr Ala Ile Leu Lys Lys Ser Ile Arg Asn Leu Gln Val Cys 
        115                 120                 125             


Thr Glu Val Gly Leu Val Glu Lys Val Leu Gly Lys Ile Glu Lys Val 
    130                 135                 140                 


Asp Asn Met Ile Ala Asp Leu Leu Val Asp Met Leu Gly Val Leu Ala 
145                 150                 155                 160 


Ser Tyr Asn Leu Thr Val Arg Glu Leu Lys Leu Phe Phe Ser Lys Leu 
                165                 170                 175     


Gln Gly Asp Lys Gly Arg Trp Pro Pro His Ala Gly Lys Leu Leu Ser 
            180                 185                 190         


Val Leu Lys His Met Pro Gln Lys Tyr Gly Pro Asp Ala Phe Phe Asn 
        195                 200                 205             


Phe Pro Gly Lys Ser Ala Ala Ala Ile Ala Leu Pro Pro Ile Ala Lys 
    210                 215                 220                 


Trp Pro Tyr Gln Asn Gly Phe Thr Phe His Thr Trp Leu Arg Met Asp 
225                 230                 235                 240 


Pro Val Asn Asn Ile Asn Val Asp Lys Asp Lys Pro Tyr Leu Tyr Cys 
                245                 250                 255     


Phe Arg Thr Ser Lys Gly Leu Gly Tyr Ser Ala His Phe Val Gly Gly 
            260                 265                 270         


Cys Leu Ile Val Thr Ser Ile Lys Ser Lys Gly Lys Gly Phe Gln His 
        275                 280                 285             


Cys Val Lys Phe Asp Phe Lys Pro Gln Lys Trp Tyr Met Val Thr Ile 
    290                 295                 300                 


Val His Ile Tyr Asn Arg Trp Lys Asn Ser Glu Leu Arg Cys Tyr Val 
305                 310                 315                 320 


Asn Gly Glu Leu Ala Ser Tyr Gly Glu Ile Thr Trp Phe Val Asn Thr 
                325                 330                 335     


Ser Asp Thr Phe Asp Lys Cys Phe Leu Gly Ser Ser Glu Thr Ala Asp 
            340                 345                 350         


Ala Asn Arg Val Phe Cys Gly Gln Met Thr Ala Val Tyr Leu Phe Ser 
        355                 360                 365             


Glu Ala Leu Asn Ala Ala Gln Ile Phe Ala Ile Tyr Gln Leu Gly Leu 
    370                 375                 380                 


Gly Tyr Lys Gly Thr Phe Lys Phe Lys Ala Glu Ser Asp Leu Phe Leu 
385                 390                 395                 400 


Ala Glu His His Lys Leu Leu Leu Tyr Asp Gly Lys Leu Ser Ser Ala 
                405                 410                 415     


Ile Ala Phe Thr Tyr Asn Pro Arg Ala Thr Asp Ala Gln Leu Cys Leu 
            420                 425                 430         


Glu Ser Ser Pro Lys Asp Asn Pro Ser Ile Phe Val His Ser Pro His 
        435                 440                 445             


Ala Leu Met Leu Gln Asp Val Lys Ala Val Leu Thr His Ser Ile Gln 
    450                 455                 460                 


Ser Ala Met His Ser Ile Gly Gly Val Gln Val Leu Phe Pro Leu Phe 
465                 470                 475                 480 


Ala Gln Leu Asp Tyr Arg Gln Tyr Leu Ser Asp Glu Ile Asp Leu Thr 
                485                 490                 495     


Ile Cys Ser Thr Leu Leu Ala Phe Ile Met Glu Leu Leu Lys Asn Ser 
            500                 505                 510         


Ile Ala Met Gln Glu Gln Met Leu Ala Cys Lys Gly Phe Leu Val Ile 
        515                 520                 525             


Gly Tyr Ser Leu Glu Lys Ser Ser Lys Ser His Val Ser Arg Ala Val 
    530                 535                 540                 


Leu Glu Leu Cys Leu Ala Phe Ser Lys Tyr Leu Ser Asn Leu Gln Asn 
545                 550                 555                 560 


Gly Met Pro Leu Leu Lys Gln Leu Cys Asp His Val Leu Leu Asn Pro 
                565                 570                 575     


Ala Ile Trp Ile His Thr Pro Ala Lys Val Gln Leu Met Leu Tyr Thr 
            580                 585                 590         


Tyr Leu Ser Thr Glu Phe Ile Gly Thr Val Asn Ile Tyr Asn Thr Ile 
        595                 600                 605             


Arg Arg Val Gly Thr Val Leu Leu Ile Met His Thr Leu Lys Tyr Tyr 
    610                 615                 620                 


Tyr Trp Ala Val Asn Pro Gln Asp Arg Ser Gly Ile Thr Pro Lys Gly 
625                 630                 635                 640 


Leu Asp Gly Pro Arg Pro Asn Gln Lys Glu Met Leu Ser Leu Arg Ala 
                645                 650                 655     


Phe Leu Leu Met Phe Ile Lys Gln Leu Val Met Lys Asp Ser Gly Val 
            660                 665                 670         


Lys Glu Asp Glu Leu Gln Ala Ile Leu Asn Tyr Leu Leu Thr Met His 
        675                 680                 685             


Glu Asp Asp Asn Leu Met Asp Val Leu Gln Leu Leu Val Ala Leu Met 
    690                 695                 700                 


Ser Glu His Pro Asn Ser Met Ile Pro Ala Phe Asp Gln Arg Asn Gly 
705                 710                 715                 720 


Leu Arg Val Ile Tyr Lys Leu Leu Ala Ser Lys Ser Glu Gly Ile Arg 
                725                 730                 735     


Val Gln Ala Leu Lys Ala Met Gly Tyr Phe Leu Lys His Leu Ala Pro 
            740                 745                 750         


Lys Arg Lys Ala Glu Val Met Leu Gly His Gly Leu Phe Ser Leu Leu 
        755                 760                 765             


Ala Glu Arg Leu Met Leu Gln Thr Asn Leu Ile Thr Met Thr Thr Tyr 
    770                 775                 780                 


Asn Val Leu Phe Glu Ile Leu Ile Glu Gln Ile Gly Thr Gln Val Ile 
785                 790                 795                 800 


His Lys Gln His Pro Asp Pro Asp Ser Ser Val Lys Ile Gln Asn Pro 
                805                 810                 815     


Gln Ile Leu Lys Val Ile Ala Thr Leu Leu Arg Asn Ser Pro Gln Cys 
            820                 825                 830         


Pro Glu Ser Met Glu Val Arg Arg Ala Phe Leu Ser Asp Met Ile Lys 
        835                 840                 845             


Leu Phe Asn Asn Ser Arg Glu Asn Arg Arg Ser Leu Leu Gln Cys Ser 
    850                 855                 860                 


Val Trp Gln Glu Trp Met Leu Ser Leu Cys Tyr Phe Asn Pro Lys Asn 
865                 870                 875                 880 


Ser Asp Glu Gln Lys Ile Thr Glu Met Val Tyr Ala Ile Phe Arg Ile 
                885                 890                 895     


Leu Leu Tyr His Ala Val Lys Tyr Glu Trp Gly Gly Trp Arg Val Trp 
            900                 905                 910         


Val Asp Thr Leu Ser Ile Thr His Ser Lys Val Thr Phe Glu Ile His 
        915                 920                 925             


Lys Glu Asn Leu Ala Asn Ile Phe Arg Glu Gln Gln Gly Lys Val Asp 
    930                 935                 940                 


Glu Glu Ile Gly Leu Cys Ser Ser Thr Ser Val Gln Ala Ala Ser Gly 
945                 950                 955                 960 


Ile Arg Arg Asp Ile Asn Val Ser Val Gly Ser Gln Gln Pro Asp Thr 
                965                 970                 975     


Lys Asp Ser Pro Val Cys Pro His Phe Thr Thr Asn Gly Asn Glu Asn 
            980                 985                 990         


Ser Ser Ile Glu Lys Thr Ser Ser  Leu Glu Ser Ala Ser  Asn Ile Glu 
        995                 1000                 1005             


Leu Gln  Thr Thr Asn Thr Ser  Tyr Glu Glu Met Lys  Ala Glu Gln 
    1010                 1015                 1020             


Glu Asn  Gln Glu Leu Pro Asp  Glu Gly Thr Leu Glu  Glu Thr Leu 
    1025                 1030                 1035             


Thr Asn  Glu Thr Arg Asn Ala  Asp Asp Leu Glu Val  Ser Ser Asp 
    1040                 1045                 1050             


Ile Ile  Glu Ala Val Ala Ile  Ser Ser Asn Ser Phe  Ile Thr Thr 
    1055                 1060                 1065             


Gly Lys  Asp Ser Met Thr Val  Ser Glu Val Thr Ala  Ser Ile Ser 
    1070                 1075                 1080             


Ser Pro  Ser Glu Glu Asp Ala  Ser Glu Met Pro Glu  Phe Leu Asp 
    1085                 1090                 1095             


Lys Ser  Ile Val Glu Glu Glu  Glu Asp Asp Asp Tyr  Val Glu Leu 
    1100                 1105                 1110             


Lys Val  Glu Gly Ser Pro Thr  Glu Glu Ala Asn Leu  Pro Thr Glu 
    1115                 1120                 1125             


Leu Gln  Asp Asn Ser Leu Ser  Pro Ala Ala Ser Glu  Ala Gly Glu 
    1130                 1135                 1140             


Lys Leu  Asp Met Phe Gly Asn  Asp Asp Lys Leu Ile  Phe Gln Glu 
    1145                 1150                 1155             


Gly Lys  Pro Val Thr Glu Lys  Gln Thr Asp Thr Glu  Thr Gln Asp 
    1160                 1165                 1170             


Ser Lys  Asp Ser Gly Ile Gln  Thr Met Thr Ala Ser  Gly Ser Ser 
    1175                 1180                 1185             


Ala Met  Ser Pro Glu Thr Thr  Val Ser Gln Ile Ala  Val Glu Ser 
    1190                 1195                 1200             


Asp Leu  Gly Gln Met Leu Glu  Glu Gly Lys Lys Ala  Thr Asn Leu 
    1205                 1210                 1215             


Thr Arg  Glu Thr Lys Leu Ile  Asn Asp Cys His Gly  Ser Val Ser 
    1220                 1225                 1230             


Glu Ala  Ser Ser Glu Gln Lys  Ile Ala Lys Leu Asp  Val Ser Asn 
    1235                 1240                 1245             


Val Ala  Thr Asp Thr Glu Arg  Leu Glu Leu Lys Ala  Ser Pro Asn 
    1250                 1255                 1260             


Val Glu  Ala Pro Gln Pro His  Arg His Val Leu Glu  Ile Ser Arg 
    1265                 1270                 1275             


Gln His  Glu Gln Pro Gly Gln  Gly Ile Ala Pro Asp  Ala Val Asn 
    1280                 1285                 1290             


Gly Gln  Arg Arg Asp Ser Arg  Ser Thr Val Phe Arg  Ile Pro Glu 
    1295                 1300                 1305             


Phe Asn  Trp Ser Gln Met His  Gln Arg Leu Leu Thr  Asp Leu Leu 
    1310                 1315                 1320             


Phe Ser  Ile Glu Thr Asp Ile  Gln Met Trp Arg Ser  His Ser Thr 
    1325                 1330                 1335             


Lys Thr  Val Met Asp Phe Val  Asn Ser Ser Asp Asn  Val Ile Phe 
    1340                 1345                 1350             


Val His  Asn Thr Ile His Leu  Ile Ser Gln Val Met  Asp Asn Met 
    1355                 1360                 1365             


Val Met  Ala Cys Gly Gly Ile  Leu Pro Leu Leu Ser  Ala Ala Thr 
    1370                 1375                 1380             


Ser Ala  Thr His Glu Leu Glu  Asn Ile Glu Pro Thr  Gln Gly Leu 
    1385                 1390                 1395             


Ser Ile  Glu Ala Ser Val Thr  Phe Leu Gln Arg Leu  Ile Ser Leu 
    1400                 1405                 1410             


Val Asp  Val Leu Ile Phe Ala  Ser Ser Leu Gly Phe  Thr Glu Ile 
    1415                 1420                 1425             


Glu Ala  Glu Lys Ser Met Ser  Ser Gly Gly Ile Leu  Arg Gln Cys 
    1430                 1435                 1440             


Leu Arg  Leu Val Cys Ala Val  Ala Val Arg Asn Cys  Leu Glu Cys 
    1445                 1450                 1455             


Gln Gln  His Ser Gln Leu Lys  Thr Arg Gly Asp Lys  Ala Leu Lys 
    1460                 1465                 1470             


Pro Met  His Ser Leu Ile Pro  Leu Gly Lys Ser Ala  Ala Lys Ser 
    1475                 1480                 1485             


Pro Val  Asp Ile Val Thr Gly  Gly Ile Ser Pro Val  Arg Asp Leu 
    1490                 1495                 1500             


Asp Arg  Leu Leu Gln Asp Met  Asp Ile Asn Arg Leu  Arg Ala Val 
    1505                 1510                 1515             


Val Phe  Arg Asp Ile Glu Asp  Ser Lys Gln Ala Gln  Phe Leu Ala 
    1520                 1525                 1530             


Leu Ala  Val Val Tyr Phe Ile  Ser Val Leu Met Val  Ser Lys Tyr 
    1535                 1540                 1545             


Arg Asp  Ile Leu Glu Pro Gln  Asn Glu Arg His Ser  Gln Ser Cys 
    1550                 1555                 1560             


Thr Glu  Thr Gly Ser Glu Asn  Glu Asn Val Ser Leu  Ser Glu Ile 
    1565                 1570                 1575             


Thr Pro  Ala Ala Phe Ser Thr  Leu Thr Thr Ala Ser  Val Glu Glu 
    1580                 1585                 1590             


Ser Glu  Ser Thr Ser Ser Ala  Arg Arg Arg Asp Ser  Gly Ile Gly 
    1595                 1600                 1605             


Glu Glu  Thr Ala Thr Gly Leu  Gly Ser His Val Glu  Val Thr Pro 
    1610                 1615                 1620             


His Thr  Ala Pro Pro Gly Val  Ser Ala Gly Pro Asp  Ala Ile Ser 
    1625                 1630                 1635             


Glu Val  Leu Ser Thr Leu Ser  Leu Glu Val Asn Lys  Ser Pro Glu 
    1640                 1645                 1650             


Thr Lys  Asn Asp Arg Gly Asn  Asp Leu Asp Thr Lys  Ala Thr Pro 
    1655                 1660                 1665             


Ser Val  Ser Val Ser Lys Asn  Val Asn Val Lys Asp  Ile Leu Arg 
    1670                 1675                 1680             


Ser Leu  Val Asn Ile Pro Ala  Asp Gly Val Thr Val  Asp Pro Ala 
    1685                 1690                 1695             


Leu Leu  Pro Pro Ala Cys Leu  Gly Ala Leu Gly Asp  Leu Ser Val 
    1700                 1705                 1710             


Glu Gln  Pro Val Gln Phe Arg  Ser Phe Asp Arg Ser  Val Ile Val 
    1715                 1720                 1725             


Ala Ala  Lys Lys Ser Ala Val  Ser Pro Ser Thr Phe  Asn Thr Ser 
    1730                 1735                 1740             


Ile Pro  Thr Asn Ala Val Ser  Val Val Ser Ser Val  Asp Ser Ala 
    1745                 1750                 1755             


Gln Ala  Ser Asp Met Gly Gly  Glu Ser Pro Gly Ser  Arg Ser Ser 
    1760                 1765                 1770             


Asn Ala  Lys Leu Pro Ser Val  Pro Thr Val Asp Ser  Val Ser Gln 
    1775                 1780                 1785             


Asp Pro  Val Ser Asn Met Ser  Ile Thr Glu Arg Leu  Glu His Ala 
    1790                 1795                 1800             


Leu Glu  Lys Ala Ala Pro Leu  Leu Arg Glu Ile Phe  Val Asp Phe 
    1805                 1810                 1815             


Ala Pro  Phe Leu Ser Arg Thr  Leu Leu Gly Ser His  Gly Gln Glu 
    1820                 1825                 1830             


Leu Leu  Ile Glu Gly Thr Ser  Leu Val Cys Met Lys  Ser Ser Ser 
    1835                 1840                 1845             


Ser Val  Val Glu Leu Val Met  Leu Leu Cys Ser Gln  Val Arg Val 
    1850                 1855                 1860             


Ala Lys  Phe Tyr Ser Glu Glu  Cys Arg Pro Cys Phe  Tyr Arg Thr 
    1865                 1870                 1875             


Cys Gln  
    1880 


<210>  190
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  190

Gly Thr Ser Phe Gly Leu Pro Gln Thr Arg Arg Ile Ser Leu Ala Ser 
1               5                   10                  15      


Pro Arg Gln Leu Phe Lys Ala Ser Asn Met Thr Gln Arg Trp Gln His 
            20                  25                  30          


Arg Glu Ile Ser Asn Phe Glu Tyr Leu Met Phe Leu Asn Thr Ile Ala 
        35                  40                  45              


Gly Arg Ser Tyr Asn Asp Leu Asn Gln Tyr Pro Val Phe Pro Trp Val 
    50                  55                  60                  


Ile Thr Asn Tyr Glu Ser Glu Glu Leu Asp Leu Thr Leu Pro Thr Asn 
65                  70                  75                  80  


Phe Arg Asp Leu Ser Lys Pro Ile Gly Ala Leu Asn Pro Lys Arg Ala 
                85                  90                  95      


Ala Phe Phe Ala Glu Arg Tyr Glu Ser Trp Glu Asp Asp Gln Val Pro 
            100                 105                 110         


Lys Phe His Tyr Gly Thr His Tyr Ser Thr Ala Ser Phe Val Leu Ala 
        115                 120                 125             


Trp Leu Leu Arg Ile Glu Pro Phe Thr Thr Tyr Phe Leu Asn Leu Gln 
    130                 135                 140                 


Gly Gly Lys Phe Asp His Ala Asp Arg Thr Phe Ser Ser Ile Ser Arg 
145                 150                 155                 160 


Ala Trp Arg Asn Ser Gln Arg Asp Thr Ser Asp Ile Lys Glu Leu Ile 
                165                 170                 175     


Pro Glu Phe Tyr Tyr Leu Pro Glu Met Phe Val Asn Phe Asn Asn Tyr 
            180                 185                 190         


Asn Leu Gly Val Met Asp Asp Gly Thr Val Val Ser Asp Val Glu Leu 
        195                 200                 205             


Pro Pro Trp Ala Lys Thr Ser Glu Glu Phe Val His Ile Asn Arg Leu 
    210                 215                 220                 


Ala Leu Glu Ser Glu Phe Val Ser Cys Gln Leu His Gln Trp Ile Asp 
225                 230                 235                 240 


Leu Ile Phe Gly Tyr Lys Gln Gln Gly Pro Glu Ala Val Arg Ala Leu 
                245                 250                 255     


Asn Val Phe Tyr Tyr Leu Thr Tyr Glu Gly Ala Val Asn Leu Asn Ser 
            260                 265                 270         


Ile Thr Asp Pro Val Leu Arg Glu Ala Val Glu Ala Gln Ile Arg Ser 
        275                 280                 285             


Phe Gly Gln Thr Pro Ser Gln Leu Leu Ile Glu Pro His Pro Pro Arg 
    290                 295                 300                 


Gly Ser Ala Met Gln Val Tyr Leu Leu Leu Gln Ser Pro Leu Met Phe 
305                 310                 315                 320 


Thr Asp Lys Ala Gln Gln Asp Val Ile Met Val Leu Lys Phe Pro Ser 
                325                 330                 335     


Asn Ser Pro Val Thr His Val Ala Ala Asn Thr Gln Pro Gly Leu Ala 
            340                 345                 350         


Thr Pro Ala Val Ile Thr Val Thr Ala Asn Arg Leu Phe Ala Val Asn 
        355                 360                 365             


Lys Trp His Asn Leu Pro Ala His Gln Gly Ala Val Gln Asp Gln Pro 
    370                 375                 380                 


Tyr Gln Leu Pro Val Glu Ile Asp Pro Leu Ile Ala Ser Asn Thr Gly 
385                 390                 395                 400 


Met His Arg Arg Gln Ile Thr Asp Leu Leu Asp Gln Ser Ile Gln Val 
                405                 410                 415     


His Ser Gln Cys Phe Val Ile Thr Ser Asp Asn Arg Tyr Ile Leu Val 
            420                 425                 430         


Cys Gly Phe Trp Asp Lys Ser Phe Arg Val Tyr Ser Thr Asp Thr Gly 
        435                 440                 445             


Arg Leu Ile Gln Val Val Phe Gly His Trp Asp Val Val Thr Cys Leu 
    450                 455                 460                 


Ala Arg Ser Glu Ser Tyr Ile Gly Gly Asn Cys Tyr Ile Leu Ser Gly 
465                 470                 475                 480 


Ser Arg Asp Ala Thr Leu Leu Leu Trp Tyr Trp Asn Gly Lys Cys Ser 
                485                 490                 495     


Gly Ile Gly Asp Asn Pro Gly Ser Glu Thr Ala Ala Pro Arg Ala Ile 
            500                 505                 510         


Leu Thr Gly His Asp Tyr Glu Val Thr Cys Ala Ala Val Cys Ala Glu 
        515                 520                 525             


Leu Gly Leu Val Leu Ser Gly Ser Gln Glu Gly Pro Cys Leu Ile His 
    530                 535                 540                 


Ser Met Asn Gly Asp Leu Leu Arg Thr Leu Glu Gly Pro Glu Asn Cys 
545                 550                 555                 560 


Leu Lys Pro Lys Leu Ile Gln Ala Ser Arg Glu Gly His Cys Val Ile 
                565                 570                 575     


Phe Tyr Glu Asn Gly Leu Phe Cys Thr Phe Ser Val Asn Gly Lys Leu 
            580                 585                 590         


Gln Ala Thr Met Glu Thr Asp Asp Asn Ile Arg Ala Ile Gln Leu Ser 
        595                 600                 605             


Arg Asp Gly Gln Tyr Leu Leu Thr Gly Gly Asp Arg Gly Val Val Val 
    610                 615                 620                 


Val Arg Gln Val Ser Asp Leu Lys Gln Leu Phe Ala Tyr Pro Gly Cys 
625                 630                 635                 640 


Asp Ala Gly Ile Arg Ala Met Ala Leu Ser Tyr Asp Gln Arg Arg Pro 
                645                 650                 655     


Arg Ser Leu Gln Lys Phe Leu Ser Ser Val Ile Ser Val His His Phe 
            660                 665                 670         


Trp His Gly Phe Arg Lys His Cys Ala Ile Leu Gln Arg Leu 
        675                 680                 685     


<210>  191
<211>  2095
<212>  PRT
<213>  Homo sapiens

<400>  191

Gly Leu Phe Ser Leu Leu Ala Glu Arg Leu Met Leu Gln Thr Asn Leu 
1               5                   10                  15      


Ile Thr Met Thr Thr Tyr Asn Val Leu Phe Glu Ile Leu Ile Glu Gln 
            20                  25                  30          


Ile Gly Thr Gln Val Ile His Lys Gln His Pro Asp Pro Asp Ser Ser 
        35                  40                  45              


Val Lys Ile Gln Asn Pro Gln Ile Leu Lys Val Ile Ala Thr Leu Leu 
    50                  55                  60                  


Arg Asn Ser Pro Gln Cys Pro Glu Ser Met Glu Val Arg Arg Ala Phe 
65                  70                  75                  80  


Leu Ser Asp Met Ile Lys Leu Phe Asn Asn Ser Arg Glu Asn Arg Arg 
                85                  90                  95      


Ser Leu Leu Gln Cys Ser Val Trp Gln Glu Trp Met Leu Ser Leu Cys 
            100                 105                 110         


Tyr Phe Asn Pro Lys Asn Ser Asp Glu Gln Lys Ile Thr Glu Met Val 
        115                 120                 125             


Tyr Ala Ile Phe Arg Ile Leu Leu Tyr His Ala Val Lys Tyr Glu Trp 
    130                 135                 140                 


Gly Gly Trp Arg Val Trp Val Asp Thr Leu Ser Ile Thr His Ser Lys 
145                 150                 155                 160 


Val Thr Phe Glu Ile His Lys Glu Asn Leu Ala Asn Ile Phe Arg Glu 
                165                 170                 175     


Gln Gln Gly Lys Val Asp Glu Glu Ile Gly Leu Cys Ser Ser Thr Ser 
            180                 185                 190         


Val Gln Ala Ala Ser Gly Ile Arg Arg Asp Ile Asn Val Ser Val Gly 
        195                 200                 205             


Ser Gln Gln Pro Asp Thr Lys Asp Ser Pro Val Cys Pro His Phe Thr 
    210                 215                 220                 


Thr Asn Gly Asn Glu Asn Ser Ser Ile Glu Lys Thr Ser Ser Leu Glu 
225                 230                 235                 240 


Ser Ala Ser Asn Ile Glu Leu Gln Thr Thr Asn Thr Ser Tyr Glu Glu 
                245                 250                 255     


Met Lys Ala Glu Gln Glu Asn Gln Glu Leu Pro Asp Glu Gly Thr Leu 
            260                 265                 270         


Glu Glu Thr Leu Thr Asn Glu Thr Arg Asn Ala Asp Asp Leu Glu Val 
        275                 280                 285             


Ser Ser Asp Ile Ile Glu Ala Val Ala Ile Ser Ser Asn Ser Phe Ile 
    290                 295                 300                 


Thr Thr Gly Lys Asp Ser Met Thr Val Ser Glu Val Thr Ala Ser Ile 
305                 310                 315                 320 


Ser Ser Pro Ser Glu Glu Asp Ala Ser Glu Met Pro Glu Phe Leu Asp 
                325                 330                 335     


Lys Ser Ile Val Glu Glu Glu Glu Asp Asp Asp Tyr Val Glu Leu Lys 
            340                 345                 350         


Val Glu Gly Ser Pro Thr Glu Glu Ala Asn Leu Pro Thr Glu Leu Gln 
        355                 360                 365             


Asp Asn Ser Leu Ser Pro Ala Ala Ser Glu Ala Gly Glu Lys Leu Asp 
    370                 375                 380                 


Met Phe Gly Asn Asp Asp Lys Leu Ile Phe Gln Glu Gly Lys Pro Val 
385                 390                 395                 400 


Thr Glu Lys Gln Thr Asp Thr Glu Thr Gln Asp Ser Lys Asp Ser Gly 
                405                 410                 415     


Ile Gln Thr Met Thr Ala Ser Gly Ser Ser Ala Met Ser Pro Glu Thr 
            420                 425                 430         


Thr Val Ser Gln Ile Ala Val Glu Ser Asp Leu Gly Gln Met Leu Glu 
        435                 440                 445             


Glu Gly Lys Lys Ala Thr Asn Leu Thr Arg Glu Thr Lys Leu Ile Asn 
    450                 455                 460                 


Asp Cys His Gly Ser Val Ser Glu Ala Ser Ser Glu Gln Lys Ile Ala 
465                 470                 475                 480 


Lys Leu Asp Val Ser Asn Val Ala Thr Asp Thr Glu Arg Leu Glu Leu 
                485                 490                 495     


Lys Ala Ser Pro Asn Val Glu Ala Pro Gln Pro His Arg His Val Leu 
            500                 505                 510         


Glu Ile Ser Arg Gln His Glu Gln Pro Gly Gln Gly Ile Ala Pro Asp 
        515                 520                 525             


Ala Val Asn Gly Gln Arg Arg Asp Ser Arg Ser Thr Val Phe Arg Ile 
    530                 535                 540                 


Pro Glu Phe Asn Trp Ser Gln Met His Gln Arg Leu Leu Thr Asp Leu 
545                 550                 555                 560 


Leu Phe Ser Ile Glu Thr Asp Ile Gln Met Trp Arg Ser His Ser Thr 
                565                 570                 575     


Lys Thr Val Met Asp Phe Val Asn Ser Ser Asp Asn Val Ile Phe Val 
            580                 585                 590         


His Asn Thr Ile His Leu Ile Ser Gln Val Met Asp Asn Met Val Met 
        595                 600                 605             


Ala Cys Gly Gly Ile Leu Pro Leu Leu Ser Ala Ala Thr Ser Ala Thr 
    610                 615                 620                 


His Glu Leu Glu Asn Ile Glu Pro Thr Gln Gly Leu Ser Ile Glu Ala 
625                 630                 635                 640 


Ser Val Thr Phe Leu Gln Arg Leu Ile Ser Leu Val Asp Val Leu Ile 
                645                 650                 655     


Phe Ala Ser Ser Leu Gly Phe Thr Glu Ile Glu Ala Glu Lys Ser Met 
            660                 665                 670         


Ser Ser Gly Gly Ile Leu Arg Gln Cys Leu Arg Leu Val Cys Ala Val 
        675                 680                 685             


Ala Val Arg Asn Cys Leu Glu Cys Gln Gln His Ser Gln Leu Lys Thr 
    690                 695                 700                 


Arg Gly Asp Lys Ala Leu Lys Pro Met His Ser Leu Ile Pro Leu Gly 
705                 710                 715                 720 


Lys Ser Ala Ala Lys Ser Pro Val Asp Ile Val Thr Gly Gly Ile Ser 
                725                 730                 735     


Pro Val Arg Asp Leu Asp Arg Leu Leu Gln Asp Met Asp Ile Asn Arg 
            740                 745                 750         


Leu Arg Ala Val Val Phe Arg Asp Ile Glu Asp Ser Lys Gln Ala Gln 
        755                 760                 765             


Phe Leu Ala Leu Ala Val Val Tyr Phe Ile Ser Val Leu Met Val Ser 
    770                 775                 780                 


Lys Tyr Arg Asp Ile Leu Glu Pro Gln Asn Glu Arg His Ser Gln Ser 
785                 790                 795                 800 


Cys Thr Glu Thr Gly Ser Glu Asn Glu Asn Val Ser Leu Ser Glu Ile 
                805                 810                 815     


Thr Pro Ala Ala Phe Ser Thr Leu Thr Thr Ala Ser Val Glu Glu Ser 
            820                 825                 830         


Glu Ser Thr Ser Ser Ala Arg Arg Arg Asp Ser Gly Ile Gly Glu Glu 
        835                 840                 845             


Thr Ala Thr Gly Leu Gly Ser His Val Glu Val Thr Pro His Thr Ala 
    850                 855                 860                 


Pro Pro Gly Val Ser Ala Gly Pro Asp Ala Ile Ser Glu Val Leu Ser 
865                 870                 875                 880 


Thr Leu Ser Leu Glu Val Asn Lys Ser Pro Glu Thr Lys Asn Asp Arg 
                885                 890                 895     


Gly Asn Asp Leu Asp Thr Lys Ala Thr Pro Ser Val Ser Val Ser Lys 
            900                 905                 910         


Asn Val Asn Val Lys Asp Ile Leu Arg Ser Leu Val Asn Ile Pro Ala 
        915                 920                 925             


Asp Gly Val Thr Val Asp Pro Ala Leu Leu Pro Pro Ala Cys Leu Gly 
    930                 935                 940                 


Ala Leu Gly Asp Leu Ser Val Glu Gln Pro Val Gln Phe Arg Ser Phe 
945                 950                 955                 960 


Asp Arg Ser Val Ile Val Ala Ala Lys Lys Ser Ala Val Ser Pro Ser 
                965                 970                 975     


Thr Phe Asn Thr Ser Ile Pro Thr Asn Ala Val Ser Val Val Ser Ser 
            980                 985                 990         


Val Asp Ser Ala Gln Ala Ser Asp  Met Gly Gly Glu Ser  Pro Gly Ser 
        995                 1000                 1005             


Arg Ser  Ser Asn Ala Lys Leu  Pro Ser Val Pro Thr  Val Asp Ser 
    1010                 1015                 1020             


Val Ser  Gln Asp Pro Val Ser  Asn Met Ser Ile Thr  Glu Arg Leu 
    1025                 1030                 1035             


Glu His  Ala Leu Glu Lys Ala  Ala Pro Leu Leu Arg  Glu Ile Phe 
    1040                 1045                 1050             


Val Asp  Phe Ala Pro Phe Leu  Ser Arg Thr Leu Leu  Gly Ser His 
    1055                 1060                 1065             


Gly Gln  Glu Leu Leu Ile Glu  Gly Thr Ser Leu Val  Cys Met Lys 
    1070                 1075                 1080             


Ser Ser  Ser Ser Val Val Glu  Leu Val Met Leu Leu  Cys Ser Gln 
    1085                 1090                 1095             


Glu Trp  Gln Asn Ser Ile Gln  Lys Asn Ala Gly Leu  Ala Phe Ile 
    1100                 1105                 1110             


Glu Leu  Val Asn Glu Gly Arg  Leu Leu Ser Gln Thr  Met Lys Asp 
    1115                 1120                 1125             


His Leu  Val Arg Val Ala Asn  Glu Ala Glu Phe Ile  Leu Ser Arg 
    1130                 1135                 1140             


Gln Arg  Ala Glu Asp Ile His  Arg His Ala Glu Phe  Glu Ser Leu 
    1145                 1150                 1155             


Cys Ala  Gln Tyr Ser Ala Asp  Lys Arg Glu Asp Glu  Lys Met Cys 
    1160                 1165                 1170             


Asp His  Leu Ile Arg Ala Ala  Lys Tyr Arg Asp His  Val Thr Ala 
    1175                 1180                 1185             


Thr Gln  Leu Ile Gln Lys Ile  Ile Asn Ile Leu Thr  Asp Lys His 
    1190                 1195                 1200             


Gly Ala  Trp Gly Asn Ser Ala  Val Ser Arg Pro Leu  Glu Phe Trp 
    1205                 1210                 1215             


Arg Leu  Asp Tyr Trp Glu Asp  Asp Leu Arg Arg Arg  Arg Arg Phe 
    1220                 1225                 1230             


Val Arg  Asn Pro Leu Gly Ser  Thr His Pro Glu Ala  Thr Leu Lys 
    1235                 1240                 1245             


Thr Ala  Val Glu His Ala Thr  Asp Glu Asp Ile Leu  Ala Lys Gly 
    1250                 1255                 1260             


Lys Gln  Ser Ile Arg Ser Gln  Ala Leu Gly Asn Gln  Asn Ser Glu 
    1265                 1270                 1275             


Asn Glu  Ile Leu Leu Glu Gly  Asp Asp Asp Thr Leu  Ser Ser Val 
    1280                 1285                 1290             


Asp Glu  Lys Asp Leu Glu Asn  Leu Ala Gly Pro Val  Ser Leu Ser 
    1295                 1300                 1305             


Thr Pro  Ala Gln Leu Val Ala  Pro Ser Val Val Val  Lys Gly Thr 
    1310                 1315                 1320             


Leu Ser  Val Thr Ser Ser Glu  Leu Tyr Phe Glu Val  Asp Glu Glu 
    1325                 1330                 1335             


Asp Pro  Asn Phe Lys Lys Ile  Asp Pro Lys Ile Leu  Ala Tyr Thr 
    1340                 1345                 1350             


Glu Gly  Leu His Gly Lys Trp  Leu Phe Thr Glu Ile  Arg Ser Ile 
    1355                 1360                 1365             


Phe Ser  Arg Arg Tyr Leu Leu  Gln Asn Thr Ala Leu  Glu Ile Phe 
    1370                 1375                 1380             


Met Ala  Asn Arg Val Ala Val  Met Phe Asn Phe Pro  Asp Pro Ala 
    1385                 1390                 1395             


Thr Val  Lys Lys Val Val Asn  Tyr Leu Pro Arg Val  Gly Val Gly 
    1400                 1405                 1410             


Thr Ser  Phe Gly Leu Pro Gln  Thr Arg Arg Ile Ser  Leu Ala Ser 
    1415                 1420                 1425             


Pro Arg  Gln Leu Phe Lys Ala  Ser Asn Met Thr Gln  Arg Trp Gln 
    1430                 1435                 1440             


His Arg  Glu Ile Ser Asn Phe  Glu Tyr Leu Met Phe  Leu Asn Thr 
    1445                 1450                 1455             


Ile Ala  Gly Arg Ser Tyr Asn  Asp Leu Asn Gln Tyr  Pro Val Phe 
    1460                 1465                 1470             


Pro Trp  Val Ile Thr Asn Tyr  Glu Ser Glu Glu Leu  Asp Leu Thr 
    1475                 1480                 1485             


Leu Pro  Thr Asn Phe Arg Asp  Leu Ser Lys Pro Ile  Gly Ala Leu 
    1490                 1495                 1500             


Asn Pro  Lys Arg Ala Ala Phe  Phe Ala Glu Arg Tyr  Glu Ser Trp 
    1505                 1510                 1515             


Glu Asp  Asp Gln Val Pro Lys  Phe His Tyr Gly Thr  His Tyr Ser 
    1520                 1525                 1530             


Thr Ala  Ser Phe Val Leu Ala  Trp Leu Leu Arg Ile  Glu Pro Phe 
    1535                 1540                 1545             


Thr Thr  Tyr Phe Leu Asn Leu  Gln Gly Gly Lys Phe  Asp His Ala 
    1550                 1555                 1560             


Asp Arg  Thr Phe Ser Ser Ile  Ser Arg Ala Trp Arg  Asn Ser Gln 
    1565                 1570                 1575             


Arg Asp  Thr Ser Asp Ile Lys  Glu Leu Ile Pro Glu  Phe Tyr Tyr 
    1580                 1585                 1590             


Leu Pro  Glu Met Phe Val Asn  Phe Asn Asn Tyr Asn  Leu Gly Val 
    1595                 1600                 1605             


Met Asp  Asp Gly Thr Val Val  Ser Asp Val Glu Leu  Pro Pro Trp 
    1610                 1615                 1620             


Ala Lys  Thr Ser Glu Glu Phe  Val His Ile Asn Arg  Leu Ala Leu 
    1625                 1630                 1635             


Glu Ser  Glu Phe Val Ser Cys  Gln Leu His Gln Trp  Ile Asp Leu 
    1640                 1645                 1650             


Ile Phe  Gly Tyr Lys Gln Gln  Gly Pro Glu Ala Val  Arg Ala Leu 
    1655                 1660                 1665             


Asn Val  Phe Tyr Tyr Leu Thr  Tyr Glu Gly Ala Val  Asn Leu Asn 
    1670                 1675                 1680             


Ser Ile  Thr Asp Pro Val Leu  Arg Glu Ala Val Glu  Ala Gln Ile 
    1685                 1690                 1695             


Arg Ser  Phe Gly Gln Thr Pro  Ser Gln Leu Leu Ile  Glu Pro His 
    1700                 1705                 1710             


Pro Pro  Arg Gly Ser Ala Met  Gln Val Tyr Leu Leu  Leu Gln Ser 
    1715                 1720                 1725             


Pro Leu  Met Phe Thr Asp Lys  Ala Gln Gln Asp Val  Ile Met Val 
    1730                 1735                 1740             


Leu Lys  Phe Pro Ser Asn Ser  Pro Val Thr His Val  Ala Ala Asn 
    1745                 1750                 1755             


Thr Gln  Pro Gly Leu Ala Thr  Pro Ala Val Ile Thr  Val Thr Ala 
    1760                 1765                 1770             


Asn Arg  Leu Phe Ala Val Asn  Lys Trp His Asn Leu  Pro Ala His 
    1775                 1780                 1785             


Gln Gly  Ala Val Gln Asp Gln  Pro Tyr Gln Leu Pro  Val Glu Ile 
    1790                 1795                 1800             


Asp Pro  Leu Ile Ala Ser Asn  Thr Gly Met His Arg  Arg Gln Ile 
    1805                 1810                 1815             


Thr Asp  Leu Leu Asp Gln Ser  Ile Gln Val His Ser  Gln Cys Phe 
    1820                 1825                 1830             


Val Ile  Thr Ser Asp Asn Arg  Tyr Ile Leu Val Cys  Gly Phe Trp 
    1835                 1840                 1845             


Asp Lys  Ser Phe Arg Val Tyr  Ser Thr Asp Thr Gly  Arg Leu Ile 
    1850                 1855                 1860             


Gln Val  Val Phe Gly His Trp  Asp Val Val Thr Cys  Leu Ala Arg 
    1865                 1870                 1875             


Ser Glu  Ser Tyr Ile Gly Gly  Asn Cys Tyr Ile Leu  Ser Gly Ser 
    1880                 1885                 1890             


Arg Asp  Ala Thr Leu Leu Leu  Trp Tyr Trp Asn Gly  Lys Cys Ser 
    1895                 1900                 1905             


Gly Ile  Gly Asp Asn Pro Gly  Ser Glu Thr Ala Ala  Pro Arg Ala 
    1910                 1915                 1920             


Ile Leu  Thr Gly His Asp Tyr  Glu Val Thr Cys Ala  Ala Val Cys 
    1925                 1930                 1935             


Ala Glu  Leu Gly Leu Val Leu  Ser Gly Ser Gln Glu  Gly Pro Cys 
    1940                 1945                 1950             


Leu Ile  His Ser Met Asn Gly  Asp Leu Leu Arg Thr  Leu Glu Gly 
    1955                 1960                 1965             


Pro Glu  Asn Cys Leu Lys Pro  Lys Leu Ile Gln Ala  Ser Arg Glu 
    1970                 1975                 1980             


Gly His  Cys Val Ile Phe Tyr  Glu Asn Gly Leu Phe  Cys Thr Phe 
    1985                 1990                 1995             


Ser Val  Asn Gly Lys Leu Gln  Ala Thr Met Glu Thr  Asp Asp Asn 
    2000                 2005                 2010             


Ile Arg  Ala Ile Gln Leu Ser  Arg Asp Gly Gln Tyr  Leu Leu Thr 
    2015                 2020                 2025             


Gly Gly  Asp Arg Gly Val Val  Val Val Arg Gln Val  Ser Asp Leu 
    2030                 2035                 2040             


Lys Gln  Leu Phe Ala Tyr Pro  Gly Cys Asp Ala Gly  Ile Arg Ala 
    2045                 2050                 2055             


Met Ala  Leu Ser Tyr Asp Gln  Arg Cys Ile Ile Ser  Gly Met Ala 
    2060                 2065                 2070             


Ser Gly  Ser Ile Val Leu Phe  Tyr Asn Asp Phe Asn  Arg Trp His 
    2075                 2080                 2085             


His Glu  Tyr Gln Thr Arg Tyr  
    2090                 2095 


<210>  192
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  192

His Tyr Ser Thr Ala Ser Phe Val Leu Ala Trp Leu Leu Arg Ile Glu 
1               5                   10                  15      


Pro Phe Thr Thr Tyr Phe Leu Asn Leu Gln Gly Gly Lys Phe Asp His 
            20                  25                  30          


Ala Asp Arg Thr Phe Ser Ser Ile Ser Arg Ala Trp Arg Asn Ser Gln 
        35                  40                  45              


Arg Asp Thr Ser Asp Ile Lys Glu Leu Ile Pro Glu Phe Tyr Tyr Leu 
    50                  55                  60                  


Pro Glu Met Phe Val Asn Phe Asn Asn Tyr Asn Leu Gly Val Met Asp 
65                  70                  75                  80  


Asp Gly Thr Val Val Ser Asp Val Glu Leu Pro Pro Trp Ala Lys Thr 
                85                  90                  95      


Ser Glu Glu Phe Val His Ile Asn Arg Leu Gln Gly Pro Glu Ala Val 
            100                 105                 110         


Arg Ala Leu Asn Val Phe Tyr Tyr Leu Thr Tyr Glu Gly Ala Val Asn 
        115                 120                 125             


Leu Asn Ser Ile Thr Asp Pro Val Leu Arg Glu Ala Val Glu Ala Gln 
    130                 135                 140                 


Ile Arg Ser Phe Gly Gln Thr Pro Ser Gln Leu Leu Ile Glu Pro His 
145                 150                 155                 160 


Pro Pro Arg Gly Ser Ala Met Gln Val Tyr Leu Leu Leu Gln Ser Pro 
                165                 170                 175     


Leu Met Phe Thr Asp Lys Ala Gln Gln Asp Val Ile Met Val Leu Lys 
            180                 185                 190         


Phe Pro Ser Asn Ser Pro Val Thr His Val Ala Ala Asn Thr Gln Pro 
        195                 200                 205             


Gly Leu Ala Thr Pro Ala Val Ile Thr Val Thr Ala Asn Arg Leu Phe 
    210                 215                 220                 


Ala Val Asn Lys Trp His Asn Leu Pro Ala His Gln Gly Ala 
225                 230                 235             


<210>  193
<211>  2851
<212>  PRT
<213>  Homo sapiens

<400>  193

Met Ala Ser Glu Asp Asn Arg Val Pro Ser Pro Pro Pro Thr Gly Asp 
1               5                   10                  15      


Asp Gly Gly Gly Gly Gly Arg Glu Glu Thr Pro Thr Glu Gly Gly Ala 
            20                  25                  30          


Leu Ser Leu Lys Pro Gly Leu Pro Ile Arg Gly Ile Arg Met Lys Phe 
        35                  40                  45              


Ala Val Leu Thr Gly Leu Val Glu Val Gly Glu Val Ser Asn Arg Asp 
    50                  55                  60                  


Ile Val Glu Thr Val Phe Asn Leu Leu Val Gly Gly Gln Phe Asp Leu 
65                  70                  75                  80  


Glu Met Asn Phe Ile Ile Gln Glu Gly Glu Ser Ile Asn Cys Met Val 
                85                  90                  95      


Asp Leu Leu Glu Lys Cys Asp Ile Thr Cys Gln Ala Glu Val Trp Ser 
            100                 105                 110         


Met Phe Thr Ala Ile Leu Lys Lys Ser Ile Arg Asn Leu Gln Val Cys 
        115                 120                 125             


Thr Glu Val Gly Leu Val Glu Lys Val Leu Gly Lys Ile Glu Lys Val 
    130                 135                 140                 


Asp Asn Met Ile Ala Asp Leu Leu Val Asp Met Leu Gly Val Leu Ala 
145                 150                 155                 160 


Ser Tyr Asn Leu Thr Val Arg Glu Leu Lys Leu Phe Phe Ser Lys Leu 
                165                 170                 175     


Gln Gly Asp Lys Gly Arg Trp Pro Pro His Ala Gly Lys Leu Leu Ser 
            180                 185                 190         


Val Leu Lys His Met Pro Gln Lys Tyr Gly Pro Asp Ala Phe Phe Asn 
        195                 200                 205             


Phe Pro Gly Lys Ser Ala Ala Ala Ile Ala Leu Pro Pro Ile Ala Lys 
    210                 215                 220                 


Trp Pro Tyr Gln Asn Gly Phe Thr Phe His Thr Trp Leu Arg Met Asp 
225                 230                 235                 240 


Pro Val Asn Asn Ile Asn Val Asp Lys Asp Lys Pro Tyr Leu Tyr Cys 
                245                 250                 255     


Phe Arg Thr Ser Lys Gly Leu Gly Tyr Ser Ala His Phe Val Gly Gly 
            260                 265                 270         


Cys Leu Ile Val Thr Ser Ile Lys Ser Lys Gly Lys Gly Phe Gln His 
        275                 280                 285             


Cys Val Lys Phe Asp Phe Lys Pro Gln Lys Trp Tyr Met Val Thr Ile 
    290                 295                 300                 


Val His Ile Tyr Asn Arg Trp Lys Asn Ser Glu Leu Arg Cys Tyr Val 
305                 310                 315                 320 


Asn Gly Glu Leu Ala Ser Tyr Gly Glu Ile Thr Trp Phe Val Asn Thr 
                325                 330                 335     


Ser Asp Thr Phe Asp Lys Cys Phe Leu Gly Ser Ser Glu Thr Ala Asp 
            340                 345                 350         


Ala Asn Arg Val Phe Cys Gly Gln Met Thr Ala Val Tyr Leu Phe Ser 
        355                 360                 365             


Glu Ala Leu Asn Ala Ala Gln Ile Phe Ala Ile Tyr Gln Leu Gly Leu 
    370                 375                 380                 


Gly Tyr Lys Gly Thr Phe Lys Phe Lys Ala Glu Ser Asp Leu Phe Leu 
385                 390                 395                 400 


Ala Glu His His Lys Leu Leu Leu Tyr Asp Gly Lys Leu Ser Ser Ala 
                405                 410                 415     


Ile Ala Phe Thr Tyr Asn Pro Arg Ala Thr Asp Ala Gln Leu Cys Leu 
            420                 425                 430         


Glu Ser Ser Pro Lys Asp Asn Pro Ser Ile Phe Val His Ser Pro His 
        435                 440                 445             


Ala Leu Met Leu Gln Asp Val Lys Ala Val Leu Thr His Ser Ile Gln 
    450                 455                 460                 


Ser Ala Met His Ser Ile Gly Gly Val Gln Val Leu Phe Pro Leu Phe 
465                 470                 475                 480 


Ala Gln Leu Asp Tyr Arg Gln Tyr Leu Ser Asp Glu Ile Asp Leu Thr 
                485                 490                 495     


Ile Cys Ser Thr Leu Leu Ala Phe Ile Met Glu Leu Leu Lys Asn Ser 
            500                 505                 510         


Ile Ala Met Gln Glu Gln Met Leu Ala Cys Lys Gly Phe Leu Val Ile 
        515                 520                 525             


Gly Tyr Ser Leu Glu Lys Ser Ser Lys Ser His Val Ser Arg Ala Val 
    530                 535                 540                 


Leu Glu Leu Cys Leu Ala Phe Ser Lys Tyr Leu Ser Asn Leu Gln Asn 
545                 550                 555                 560 


Gly Met Pro Leu Leu Lys Gln Leu Cys Asp His Val Leu Leu Asn Pro 
                565                 570                 575     


Ala Ile Trp Ile His Thr Pro Ala Lys Val Gln Leu Met Leu Tyr Thr 
            580                 585                 590         


Tyr Leu Ser Thr Glu Phe Ile Gly Thr Val Asn Ile Tyr Asn Thr Ile 
        595                 600                 605             


Arg Arg Val Gly Thr Val Leu Leu Ile Met His Thr Leu Lys Tyr Tyr 
    610                 615                 620                 


Tyr Trp Ala Val Asn Pro Gln Asp Arg Ser Gly Ile Thr Pro Lys Gly 
625                 630                 635                 640 


Leu Asp Gly Pro Arg Pro Asn Gln Lys Glu Met Leu Ser Leu Arg Ala 
                645                 650                 655     


Phe Leu Leu Met Phe Ile Lys Gln Leu Val Met Lys Asp Ser Gly Val 
            660                 665                 670         


Lys Glu Asp Glu Leu Gln Ala Ile Leu Asn Tyr Leu Leu Thr Met His 
        675                 680                 685             


Glu Asp Asp Asn Leu Met Asp Val Leu Gln Leu Leu Val Ala Leu Met 
    690                 695                 700                 


Ser Glu His Pro Asn Ser Met Ile Pro Ala Phe Asp Gln Arg Asn Gly 
705                 710                 715                 720 


Leu Arg Val Ile Tyr Lys Leu Leu Ala Ser Lys Ser Glu Gly Ile Arg 
                725                 730                 735     


Val Gln Ala Leu Lys Ala Met Gly Tyr Phe Leu Lys His Leu Ala Pro 
            740                 745                 750         


Lys Arg Lys Ala Glu Val Met Leu Gly His Gly Leu Phe Ser Leu Leu 
        755                 760                 765             


Ala Glu Arg Leu Met Leu Gln Thr Asn Leu Ile Thr Met Thr Thr Tyr 
    770                 775                 780                 


Asn Val Leu Phe Glu Ile Leu Ile Glu Gln Ile Gly Thr Gln Val Ile 
785                 790                 795                 800 


His Lys Gln His Pro Asp Pro Asp Ser Ser Val Lys Ile Gln Asn Pro 
                805                 810                 815     


Gln Ile Leu Lys Val Ile Ala Thr Leu Leu Arg Asn Ser Pro Gln Cys 
            820                 825                 830         


Pro Glu Ser Met Glu Val Arg Arg Ala Phe Leu Ser Asp Met Ile Lys 
        835                 840                 845             


Leu Phe Asn Asn Ser Arg Glu Asn Arg Arg Ser Leu Leu Gln Cys Ser 
    850                 855                 860                 


Val Trp Gln Glu Trp Met Leu Ser Leu Cys Tyr Phe Asn Pro Lys Asn 
865                 870                 875                 880 


Ser Asp Glu Gln Lys Ile Thr Glu Met Val Tyr Ala Ile Phe Arg Ile 
                885                 890                 895     


Leu Leu Tyr His Ala Val Lys Tyr Glu Trp Gly Gly Trp Arg Val Trp 
            900                 905                 910         


Val Asp Thr Leu Ser Ile Thr His Ser Lys Val Thr Phe Glu Ile His 
        915                 920                 925             


Lys Glu Asn Leu Ala Asn Ile Phe Arg Glu Gln Gln Gly Lys Val Asp 
    930                 935                 940                 


Glu Glu Ile Gly Leu Cys Ser Ser Thr Ser Val Gln Ala Ala Ser Gly 
945                 950                 955                 960 


Ile Arg Arg Asp Ile Asn Val Ser Val Gly Ser Gln Gln Pro Asp Thr 
                965                 970                 975     


Lys Asp Ser Pro Val Cys Pro His Phe Thr Thr Asn Gly Asn Glu Asn 
            980                 985                 990         


Ser Ser Ile Glu Lys Thr Ser Ser  Leu Glu Ser Ala Ser  Asn Ile Glu 
        995                 1000                 1005             


Leu Gln  Thr Thr Asn Thr Ser  Tyr Glu Glu Met Lys  Ala Glu Gln 
    1010                 1015                 1020             


Glu Asn  Gln Glu Leu Pro Asp  Glu Gly Thr Leu Glu  Glu Thr Leu 
    1025                 1030                 1035             


Thr Asn  Glu Thr Arg Asn Ala  Asp Asp Leu Glu Val  Ser Ser Asp 
    1040                 1045                 1050             


Ile Ile  Glu Ala Val Ala Ile  Ser Ser Asn Ser Phe  Ile Thr Thr 
    1055                 1060                 1065             


Gly Lys  Asp Ser Met Thr Val  Ser Glu Val Thr Ala  Ser Ile Ser 
    1070                 1075                 1080             


Ser Pro  Ser Glu Glu Asp Ala  Ser Glu Met Pro Glu  Phe Leu Asp 
    1085                 1090                 1095             


Lys Ser  Ile Val Glu Glu Glu  Glu Asp Asp Asp Tyr  Val Glu Leu 
    1100                 1105                 1110             


Lys Val  Glu Gly Ser Pro Thr  Glu Glu Ala Asn Leu  Pro Thr Glu 
    1115                 1120                 1125             


Leu Gln  Asp Asn Ser Leu Ser  Pro Ala Ala Ser Glu  Ala Gly Glu 
    1130                 1135                 1140             


Lys Leu  Asp Met Phe Gly Asn  Asp Asp Lys Leu Ile  Phe Gln Glu 
    1145                 1150                 1155             


Gly Lys  Pro Val Thr Glu Lys  Gln Thr Asp Thr Glu  Thr Gln Asp 
    1160                 1165                 1170             


Ser Lys  Asp Ser Gly Ile Gln  Thr Met Thr Ala Ser  Gly Ser Ser 
    1175                 1180                 1185             


Ala Met  Ser Pro Glu Thr Thr  Val Ser Gln Ile Ala  Val Glu Ser 
    1190                 1195                 1200             


Asp Leu  Gly Gln Met Leu Glu  Glu Gly Lys Lys Ala  Thr Asn Leu 
    1205                 1210                 1215             


Thr Arg  Glu Thr Lys Leu Ile  Asn Asp Cys His Gly  Ser Val Ser 
    1220                 1225                 1230             


Glu Ala  Ser Ser Glu Gln Lys  Ile Ala Lys Leu Asp  Val Ser Asn 
    1235                 1240                 1245             


Val Ala  Thr Asp Thr Glu Arg  Leu Glu Leu Lys Ala  Ser Pro Asn 
    1250                 1255                 1260             


Val Glu  Ala Pro Gln Pro His  Arg His Val Leu Glu  Ile Ser Arg 
    1265                 1270                 1275             


Gln His  Glu Gln Pro Gly Gln  Gly Ile Ala Pro Asp  Ala Val Asn 
    1280                 1285                 1290             


Gly Gln  Arg Arg Asp Ser Arg  Ser Thr Val Phe Arg  Ile Pro Glu 
    1295                 1300                 1305             


Phe Asn  Trp Ser Gln Met His  Gln Arg Leu Leu Thr  Asp Leu Leu 
    1310                 1315                 1320             


Phe Ser  Ile Glu Thr Asp Ile  Gln Met Trp Arg Ser  His Ser Thr 
    1325                 1330                 1335             


Lys Thr  Val Met Asp Phe Val  Asn Ser Ser Asp Asn  Val Ile Phe 
    1340                 1345                 1350             


Val His  Asn Thr Ile His Leu  Ile Ser Gln Val Met  Asp Asn Met 
    1355                 1360                 1365             


Val Met  Ala Cys Gly Gly Ile  Leu Pro Leu Leu Ser  Ala Ala Thr 
    1370                 1375                 1380             


Ser Ala  Thr His Glu Leu Glu  Asn Ile Glu Pro Thr  Gln Gly Leu 
    1385                 1390                 1395             


Ser Ile  Glu Ala Ser Val Thr  Phe Leu Gln Arg Leu  Ile Ser Leu 
    1400                 1405                 1410             


Val Asp  Val Leu Ile Phe Ala  Ser Ser Leu Gly Phe  Thr Glu Ile 
    1415                 1420                 1425             


Glu Ala  Glu Lys Ser Met Ser  Ser Gly Gly Ile Leu  Arg Gln Cys 
    1430                 1435                 1440             


Leu Arg  Leu Val Cys Ala Val  Ala Val Arg Asn Cys  Leu Glu Cys 
    1445                 1450                 1455             


Gln Gln  His Ser Gln Leu Lys  Thr Arg Gly Asp Lys  Ala Leu Lys 
    1460                 1465                 1470             


Pro Met  His Ser Leu Ile Pro  Leu Gly Lys Ser Ala  Ala Lys Ser 
    1475                 1480                 1485             


Pro Val  Asp Ile Val Thr Gly  Gly Ile Ser Pro Val  Arg Asp Leu 
    1490                 1495                 1500             


Asp Arg  Leu Leu Gln Asp Met  Asp Ile Asn Arg Leu  Arg Ala Val 
    1505                 1510                 1515             


Val Phe  Arg Asp Ile Glu Asp  Ser Lys Gln Ala Gln  Phe Leu Ala 
    1520                 1525                 1530             


Leu Ala  Val Val Tyr Phe Ile  Ser Val Leu Met Val  Ser Lys Tyr 
    1535                 1540                 1545             


Arg Asp  Ile Leu Glu Pro Gln  Asn Glu Arg His Ser  Gln Ser Cys 
    1550                 1555                 1560             


Thr Glu  Thr Gly Ser Glu Asn  Glu Asn Val Ser Leu  Ser Glu Ile 
    1565                 1570                 1575             


Thr Pro  Ala Ala Phe Ser Thr  Leu Thr Thr Ala Ser  Val Glu Glu 
    1580                 1585                 1590             


Ser Glu  Ser Thr Ser Ser Ala  Arg Arg Arg Asp Ser  Gly Ile Gly 
    1595                 1600                 1605             


Glu Glu  Thr Ala Thr Gly Leu  Gly Ser His Val Glu  Val Thr Pro 
    1610                 1615                 1620             


His Thr  Ala Pro Pro Gly Val  Ser Ala Gly Pro Asp  Ala Ile Ser 
    1625                 1630                 1635             


Glu Val  Leu Ser Thr Leu Ser  Leu Glu Val Asn Lys  Ser Pro Glu 
    1640                 1645                 1650             


Thr Lys  Asn Asp Arg Gly Asn  Asp Leu Asp Thr Lys  Ala Thr Pro 
    1655                 1660                 1665             


Ser Val  Ser Val Ser Lys Asn  Val Asn Val Lys Asp  Ile Leu Arg 
    1670                 1675                 1680             


Ser Leu  Val Asn Ile Pro Ala  Asp Gly Val Thr Val  Asp Pro Ala 
    1685                 1690                 1695             


Leu Leu  Pro Pro Ala Cys Leu  Gly Ala Leu Gly Asp  Leu Ser Val 
    1700                 1705                 1710             


Glu Gln  Pro Val Gln Phe Arg  Ser Phe Asp Arg Ser  Val Ile Val 
    1715                 1720                 1725             


Ala Ala  Lys Lys Ser Ala Val  Ser Pro Ser Thr Phe  Asn Thr Ser 
    1730                 1735                 1740             


Ile Pro  Thr Asn Ala Val Ser  Val Val Ser Ser Val  Asp Ser Ala 
    1745                 1750                 1755             


Gln Ala  Ser Asp Met Gly Gly  Glu Ser Pro Gly Ser  Arg Ser Ser 
    1760                 1765                 1770             


Asn Ala  Lys Leu Pro Ser Val  Pro Thr Val Asp Ser  Val Ser Gln 
    1775                 1780                 1785             


Asp Pro  Val Ser Asn Met Ser  Ile Thr Glu Arg Leu  Glu His Ala 
    1790                 1795                 1800             


Leu Glu  Lys Ala Ala Pro Leu  Leu Arg Glu Ile Phe  Val Asp Phe 
    1805                 1810                 1815             


Ala Pro  Phe Leu Ser Arg Thr  Leu Leu Gly Ser His  Gly Gln Glu 
    1820                 1825                 1830             


Leu Leu  Ile Glu Gly Thr Ser  Leu Val Cys Met Lys  Ser Ser Ser 
    1835                 1840                 1845             


Ser Val  Val Glu Leu Val Met  Leu Leu Cys Ser Gln  Glu Trp Gln 
    1850                 1855                 1860             


Asn Ser  Ile Gln Lys Asn Ala  Gly Leu Ala Phe Ile  Glu Leu Val 
    1865                 1870                 1875             


Asn Glu  Gly Arg Leu Leu Ser  Gln Thr Met Lys Asp  His Leu Val 
    1880                 1885                 1890             


Arg Val  Ala Asn Glu Ala Glu  Phe Ile Leu Ser Arg  Gln Arg Ala 
    1895                 1900                 1905             


Glu Asp  Ile His Arg His Ala  Glu Phe Glu Ser Leu  Cys Ala Gln 
    1910                 1915                 1920             


Tyr Ser  Ala Asp Lys Arg Glu  Asp Glu Lys Met Cys  Asp His Leu 
    1925                 1930                 1935             


Ile Arg  Ala Ala Lys Tyr Arg  Asp His Val Thr Ala  Thr Gln Leu 
    1940                 1945                 1950             


Ile Gln  Lys Ile Ile Asn Ile  Leu Thr Asp Lys His  Gly Ala Trp 
    1955                 1960                 1965             


Gly Asn  Ser Ala Val Ser Arg  Pro Leu Glu Phe Trp  Arg Leu Asp 
    1970                 1975                 1980             


Tyr Trp  Glu Asp Asp Leu Arg  Arg Arg Arg Arg Phe  Val Arg Asn 
    1985                 1990                 1995             


Pro Leu  Gly Ser Thr His Pro  Glu Ala Thr Leu Lys  Thr Ala Val 
    2000                 2005                 2010             


Glu His  Ala Thr Asp Glu Asp  Ile Leu Ala Lys Gly  Lys Gln Ser 
    2015                 2020                 2025             


Ile Arg  Ser Gln Ala Leu Gly  Asn Gln Asn Ser Glu  Asn Glu Ile 
    2030                 2035                 2040             


Leu Leu  Glu Gly Asp Asp Asp  Thr Leu Ser Ser Val  Asp Glu Lys 
    2045                 2050                 2055             


Asp Leu  Glu Asn Leu Ala Gly  Pro Val Ser Leu Ser  Thr Pro Ala 
    2060                 2065                 2070             


Gln Leu  Val Ala Pro Ser Val  Val Val Lys Gly Thr  Leu Ser Val 
    2075                 2080                 2085             


Thr Ser  Ser Glu Leu Tyr Phe  Glu Val Asp Glu Glu  Asp Pro Asn 
    2090                 2095                 2100             


Phe Lys  Lys Ile Asp Pro Lys  Ile Leu Ala Tyr Thr  Glu Gly Leu 
    2105                 2110                 2115             


His Gly  Lys Trp Leu Phe Thr  Glu Ile Arg Ser Ile  Phe Ser Arg 
    2120                 2125                 2130             


Arg Tyr  Leu Leu Gln Asn Thr  Ala Leu Glu Ile Phe  Met Ala Asn 
    2135                 2140                 2145             


Arg Val  Ala Val Met Phe Asn  Phe Pro Asp Pro Ala  Thr Val Lys 
    2150                 2155                 2160             


Lys Val  Val Asn Tyr Leu Pro  Arg Val Gly Val Gly  Thr Ser Phe 
    2165                 2170                 2175             


Gly Leu  Pro Gln Thr Arg Arg  Ile Ser Leu Ala Ser  Pro Arg Gln 
    2180                 2185                 2190             


Leu Phe  Lys Ala Ser Asn Met  Thr Gln Arg Trp Gln  His Arg Glu 
    2195                 2200                 2205             


Ile Ser  Asn Phe Glu Tyr Leu  Met Phe Leu Asn Thr  Ile Ala Gly 
    2210                 2215                 2220             


Arg Ser  Tyr Asn Asp Leu Asn  Gln Tyr Pro Val Phe  Pro Trp Val 
    2225                 2230                 2235             


Ile Thr  Asn Tyr Glu Ser Glu  Glu Leu Asp Leu Thr  Leu Pro Thr 
    2240                 2245                 2250             


Asn Phe  Arg Asp Leu Ser Lys  Pro Ile Gly Ala Leu  Asn Pro Lys 
    2255                 2260                 2265             


Arg Ala  Ala Phe Phe Ala Glu  Arg Tyr Glu Ser Trp  Glu Asp Asp 
    2270                 2275                 2280             


Gln Val  Pro Lys Phe His Tyr  Gly Thr His Tyr Ser  Thr Ala Ser 
    2285                 2290                 2295             


Phe Val  Leu Ala Trp Leu Leu  Arg Ile Glu Pro Phe  Thr Thr Tyr 
    2300                 2305                 2310             


Phe Leu  Asn Leu Gln Gly Gly  Lys Phe Asp His Ala  Asp Arg Thr 
    2315                 2320                 2325             


Phe Ser  Ser Ile Ser Arg Ala  Trp Arg Asn Ser Gln  Arg Asp Thr 
    2330                 2335                 2340             


Ser Asp  Ile Lys Glu Leu Ile  Pro Glu Phe Tyr Tyr  Leu Pro Glu 
    2345                 2350                 2355             


Met Phe  Val Asn Phe Asn Asn  Tyr Asn Leu Gly Val  Met Asp Asp 
    2360                 2365                 2370             


Gly Thr  Val Val Ser Asp Val  Glu Leu Pro Pro Trp  Ala Lys Thr 
    2375                 2380                 2385             


Ser Glu  Glu Phe Val His Ile  Asn Arg Leu Ala Leu  Glu Ser Glu 
    2390                 2395                 2400             


Phe Val  Ser Cys Gln Leu His  Gln Trp Ile Asp Leu  Ile Phe Gly 
    2405                 2410                 2415             


Tyr Lys  Gln Gln Gly Pro Glu  Ala Val Arg Ala Leu  Asn Val Phe 
    2420                 2425                 2430             


Tyr Tyr  Leu Thr Tyr Glu Gly  Ala Val Asn Leu Asn  Ser Ile Thr 
    2435                 2440                 2445             


Asp Pro  Val Leu Arg Glu Ala  Val Glu Ala Gln Ile  Arg Ser Phe 
    2450                 2455                 2460             


Gly Gln  Thr Pro Ser Gln Leu  Leu Ile Glu Pro His  Pro Pro Arg 
    2465                 2470                 2475             


Gly Ser  Ala Met Gln Val Ser  Pro Leu Met Phe Thr  Asp Lys Ala 
    2480                 2485                 2490             


Gln Gln  Asp Val Ile Met Val  Leu Lys Phe Pro Ser  Asn Ser Pro 
    2495                 2500                 2505             


Val Thr  His Val Ala Ala Asn  Thr Gln Pro Gly Leu  Ala Thr Pro 
    2510                 2515                 2520             


Ala Val  Ile Thr Val Thr Ala  Asn Arg Leu Phe Ala  Val Asn Lys 
    2525                 2530                 2535             


Trp His  Asn Leu Pro Ala His  Gln Gly Ala Val Gln  Asp Gln Pro 
    2540                 2545                 2550             


Tyr Gln  Leu Pro Val Glu Ile  Asp Pro Leu Ile Ala  Ser Asn Thr 
    2555                 2560                 2565             


Gly Met  His Arg Arg Gln Ile  Thr Asp Leu Leu Asp  Gln Ser Ile 
    2570                 2575                 2580             


Gln Val  His Ser Gln Cys Phe  Val Ile Thr Ser Asp  Asn Arg Tyr 
    2585                 2590                 2595             


Ile Leu  Val Cys Gly Phe Trp  Asp Lys Ser Phe Arg  Val Tyr Ser 
    2600                 2605                 2610             


Thr Asp  Thr Gly Arg Leu Ile  Gln Val Val Phe Gly  His Trp Asp 
    2615                 2620                 2625             


Val Val  Thr Cys Leu Ala Arg  Ser Glu Ser Tyr Ile  Gly Gly Asn 
    2630                 2635                 2640             


Cys Tyr  Ile Leu Ser Gly Ser  Arg Asp Ala Thr Leu  Leu Leu Trp 
    2645                 2650                 2655             


Tyr Trp  Asn Gly Lys Cys Ser  Gly Ile Gly Asp Asn  Pro Gly Glu 
    2660                 2665                 2670             


Thr Ala  Ala Pro Arg Ala Ile  Leu Thr Gly His Asp  Tyr Glu Val 
    2675                 2680                 2685             


Thr Cys  Ala Ala Val Cys Ala  Glu Leu Gly Leu Val  Leu Ser Gly 
    2690                 2695                 2700             


Ser Gln  Glu Gly Pro Cys Leu  Ile His Ser Met Asn  Gly Asp Leu 
    2705                 2710                 2715             


Leu Arg  Thr Leu Glu Gly Pro  Glu Asn Cys Leu Lys  Pro Lys Leu 
    2720                 2725                 2730             


Ile Gln  Ala Ser Arg Glu Gly  His Cys Val Ile Phe  Tyr Glu Asn 
    2735                 2740                 2745             


Gly Leu  Phe Cys Thr Phe Ser  Val Asn Gly Lys Leu  Gln Ala Thr 
    2750                 2755                 2760             


Met Glu  Thr Asp Asp Asn Ile  Arg Ala Ile Gln Leu  Ser Arg Asp 
    2765                 2770                 2775             


Gly Gln  Tyr Leu Leu Thr Gly  Gly Asp Arg Gly Val  Val Val Val 
    2780                 2785                 2790             


Arg Gln  Val Ser Asp Leu Lys  Gln Leu Phe Ala Tyr  Pro Gly Cys 
    2795                 2800                 2805             


Asp Ala  Gly Ile Arg Ala Met  Ala Leu Ser Tyr Asp  Gln Arg Cys 
    2810                 2815                 2820             


Ile Ile  Ser Gly Met Ala Ser  Gly Ser Ile Val Leu  Phe Tyr Asn 
    2825                 2830                 2835             


Asp Phe  Asn Arg Trp His His  Glu Tyr Gln Thr Arg  Tyr 
    2840                 2845                 2850     


<210>  194
<211>  242
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  194

Xaa Thr Val Lys Lys Val Val Asn Tyr Leu Pro Arg Val Gly Val Gly 
1               5                   10                  15      


Thr Ser Phe Gly Leu Pro Gln Thr Arg Arg Ile Ser Leu Ala Ser Pro 
            20                  25                  30          


Arg Gln Leu Phe Lys Ala Ser Asn Met Thr Gln Arg Trp Gln His Arg 
        35                  40                  45              


Glu Ile Ser Asn Phe Glu Tyr Leu Met Phe Leu Asn Thr Ile Ala Gly 
    50                  55                  60                  


Arg Ser Tyr Asn Asp Leu Asn Gln Tyr Pro Val Phe Pro Trp Val Ile 
65                  70                  75                  80  


Thr Asn Tyr Glu Ser Glu Glu Leu Asp Leu Thr Leu Pro Thr Asn Phe 
                85                  90                  95      


Arg Asp Leu Ser Lys Pro Ile Gly Ala Leu Asn Pro Lys Arg Ala Ala 
            100                 105                 110         


Phe Phe Ala Glu Arg Tyr Glu Ser Trp Glu Asp Asp Gln Val Pro Lys 
        115                 120                 125             


Phe His Tyr Gly Thr His Tyr Ser Thr Ala Ser Phe Val Leu Ala Trp 
    130                 135                 140                 


Leu Leu Arg Ile Glu Pro Phe Thr Thr Tyr Phe Leu Asn Leu Gln Gly 
145                 150                 155                 160 


Gly Lys Phe Asp His Ala Asp Arg Thr Phe Ser Ser Ile Ser Arg Ala 
                165                 170                 175     


Trp Arg Asn Ser Gln Arg Asp Thr Ser Asp Ile Lys Glu Leu Ile Pro 
            180                 185                 190         


Glu Phe Tyr Tyr Leu Pro Glu Met Phe Val Asn Phe Asn Asn Tyr Asn 
        195                 200                 205             


Leu Gly Val Met Asp Asp Gly Thr Val Val Ser Asp Val Glu Leu Pro 
    210                 215                 220                 


Pro Trp Ala Lys Thr Ser Glu Glu Phe Val His Ile Asn Arg Leu Val 
225                 230                 235                 240 


Pro Phe 
        


<210>  195
<211>  2852
<212>  PRT
<213>  Homo sapiens

<400>  195

Met Ala Ser Glu Asp Asn Arg Val Pro Ser Pro Pro Pro Thr Gly Asp 
1               5                   10                  15      


Asp Gly Gly Gly Gly Gly Arg Glu Glu Thr Pro Thr Glu Gly Gly Ala 
            20                  25                  30          


Leu Ser Leu Lys Pro Gly Leu Pro Ile Arg Gly Ile Arg Met Lys Phe 
        35                  40                  45              


Ala Val Leu Thr Gly Leu Val Glu Val Gly Glu Val Ser Asn Arg Asp 
    50                  55                  60                  


Ile Val Glu Thr Val Phe Asn Leu Leu Val Gly Gly Gln Phe Asp Leu 
65                  70                  75                  80  


Glu Met Asn Phe Ile Ile Gln Glu Gly Glu Ser Ile Asn Cys Met Val 
                85                  90                  95      


Asp Leu Leu Glu Lys Cys Asp Ile Thr Cys Gln Ala Glu Val Trp Ser 
            100                 105                 110         


Met Phe Thr Ala Ile Leu Lys Lys Ser Ile Arg Asn Leu Gln Val Cys 
        115                 120                 125             


Thr Glu Val Gly Leu Val Glu Lys Val Leu Gly Lys Ile Glu Lys Val 
    130                 135                 140                 


Asp Asn Met Ile Ala Asp Leu Leu Val Asp Met Leu Gly Val Leu Ala 
145                 150                 155                 160 


Ser Tyr Asn Leu Thr Val Arg Glu Leu Lys Leu Phe Phe Ser Lys Leu 
                165                 170                 175     


Gln Gly Asp Lys Gly Arg Trp Pro Pro His Ala Gly Lys Leu Leu Ser 
            180                 185                 190         


Val Leu Lys His Met Pro Gln Lys Tyr Gly Pro Asp Ala Phe Phe Asn 
        195                 200                 205             


Phe Pro Gly Lys Ser Ala Ala Ala Ile Ala Leu Pro Pro Ile Ala Lys 
    210                 215                 220                 


Trp Pro Tyr Gln Asn Gly Phe Thr Phe His Thr Trp Leu Arg Met Asp 
225                 230                 235                 240 


Pro Val Asn Asn Ile Asn Val Asp Lys Asp Lys Pro Tyr Leu Tyr Cys 
                245                 250                 255     


Phe Arg Thr Ser Lys Gly Leu Gly Tyr Ser Ala His Phe Val Gly Gly 
            260                 265                 270         


Cys Leu Ile Val Thr Ser Ile Lys Ser Lys Gly Lys Gly Phe Gln His 
        275                 280                 285             


Cys Val Lys Phe Asp Phe Lys Pro Gln Lys Trp Tyr Met Val Thr Ile 
    290                 295                 300                 


Val His Ile Tyr Asn Arg Trp Lys Asn Ser Glu Leu Arg Cys Tyr Val 
305                 310                 315                 320 


Asn Gly Glu Leu Ala Ser Tyr Gly Glu Ile Thr Trp Phe Val Asn Thr 
                325                 330                 335     


Ser Asp Thr Phe Asp Lys Cys Phe Leu Gly Ser Ser Glu Thr Ala Asp 
            340                 345                 350         


Ala Asn Arg Val Phe Cys Gly Gln Met Thr Ala Val Tyr Leu Phe Ser 
        355                 360                 365             


Glu Ala Leu Asn Ala Ala Gln Ile Phe Ala Ile Tyr Gln Leu Gly Leu 
    370                 375                 380                 


Gly Tyr Lys Gly Thr Phe Lys Phe Lys Ala Glu Ser Asp Leu Phe Leu 
385                 390                 395                 400 


Ala Glu His His Lys Leu Leu Leu Tyr Asp Gly Lys Leu Ser Ser Ala 
                405                 410                 415     


Ile Ala Phe Thr Tyr Asn Pro Arg Ala Thr Asp Ala Gln Leu Cys Leu 
            420                 425                 430         


Glu Ser Ser Pro Lys Asp Asn Pro Ser Ile Phe Val His Ser Pro His 
        435                 440                 445             


Ala Leu Met Leu Gln Asp Val Lys Ala Val Leu Thr His Ser Ile Gln 
    450                 455                 460                 


Ser Ala Met His Ser Ile Gly Gly Val Gln Val Leu Phe Pro Leu Phe 
465                 470                 475                 480 


Ala Gln Leu Asp Tyr Arg Gln Tyr Leu Ser Asp Glu Ile Asp Leu Thr 
                485                 490                 495     


Ile Cys Ser Thr Leu Leu Ala Phe Ile Met Glu Leu Leu Lys Asn Ser 
            500                 505                 510         


Ile Ala Met Gln Glu Gln Met Leu Ala Cys Lys Gly Phe Leu Val Ile 
        515                 520                 525             


Gly Tyr Ser Leu Glu Lys Ser Ser Lys Ser His Val Ser Arg Ala Val 
    530                 535                 540                 


Leu Glu Leu Cys Leu Ala Phe Ser Lys Tyr Leu Ser Asn Leu Gln Asn 
545                 550                 555                 560 


Gly Met Pro Leu Leu Lys Gln Leu Cys Asp His Val Leu Leu Asn Pro 
                565                 570                 575     


Ala Ile Trp Ile His Thr Pro Ala Lys Val Gln Leu Met Leu Tyr Thr 
            580                 585                 590         


Tyr Leu Ser Thr Glu Phe Ile Gly Thr Val Asn Ile Tyr Asn Thr Ile 
        595                 600                 605             


Arg Arg Val Gly Thr Val Leu Leu Ile Met His Thr Leu Lys Tyr Tyr 
    610                 615                 620                 


Tyr Trp Ala Val Asn Pro Gln Asp Arg Ser Gly Ile Thr Pro Lys Gly 
625                 630                 635                 640 


Leu Asp Gly Pro Arg Pro Asn Gln Lys Glu Met Leu Ser Leu Arg Ala 
                645                 650                 655     


Phe Leu Leu Met Phe Ile Lys Gln Leu Val Met Lys Asp Ser Gly Val 
            660                 665                 670         


Lys Glu Asp Glu Leu Gln Ala Ile Leu Asn Tyr Leu Leu Thr Met His 
        675                 680                 685             


Glu Asp Asp Asn Leu Met Asp Val Leu Gln Leu Leu Val Ala Leu Met 
    690                 695                 700                 


Ser Glu His Pro Asn Ser Met Ile Pro Ala Phe Asp Gln Arg Asn Gly 
705                 710                 715                 720 


Leu Arg Val Ile Tyr Lys Leu Leu Ala Ser Lys Ser Glu Gly Ile Arg 
                725                 730                 735     


Val Gln Ala Leu Lys Ala Met Gly Tyr Phe Leu Lys His Leu Ala Pro 
            740                 745                 750         


Lys Arg Lys Ala Glu Val Met Leu Gly His Gly Leu Phe Ser Leu Leu 
        755                 760                 765             


Ala Glu Arg Leu Met Leu Gln Thr Asn Leu Ile Thr Met Thr Thr Tyr 
    770                 775                 780                 


Asn Val Leu Phe Glu Ile Leu Ile Glu Gln Ile Gly Thr Gln Val Ile 
785                 790                 795                 800 


His Lys Gln His Pro Asp Pro Asp Ser Ser Val Lys Ile Gln Asn Pro 
                805                 810                 815     


Gln Ile Leu Lys Val Ile Ala Thr Leu Leu Arg Asn Ser Pro Gln Cys 
            820                 825                 830         


Pro Glu Ser Met Glu Val Arg Arg Ala Phe Leu Ser Asp Met Ile Lys 
        835                 840                 845             


Leu Phe Asn Asn Ser Arg Glu Asn Arg Arg Ser Leu Leu Gln Cys Ser 
    850                 855                 860                 


Val Trp Gln Glu Trp Met Leu Ser Leu Cys Tyr Phe Asn Pro Lys Asn 
865                 870                 875                 880 


Ser Asp Glu Gln Lys Ile Thr Glu Met Val Tyr Ala Ile Phe Arg Ile 
                885                 890                 895     


Leu Leu Tyr His Ala Val Lys Tyr Glu Trp Gly Gly Trp Arg Val Trp 
            900                 905                 910         


Val Asp Thr Leu Ser Ile Thr His Ser Lys Val Thr Phe Glu Ile His 
        915                 920                 925             


Lys Glu Asn Leu Ala Asn Ile Phe Arg Glu Gln Gln Gly Lys Val Asp 
    930                 935                 940                 


Glu Glu Ile Gly Leu Cys Ser Ser Thr Ser Val Gln Ala Ala Ser Gly 
945                 950                 955                 960 


Ile Arg Arg Asp Ile Asn Val Ser Val Gly Ser Gln Gln Pro Asp Thr 
                965                 970                 975     


Lys Asp Ser Pro Val Cys Pro His Phe Thr Thr Asn Gly Asn Glu Asn 
            980                 985                 990         


Ser Ser Ile Glu Lys Thr Ser Ser  Leu Glu Ser Ala Ser  Asn Ile Glu 
        995                 1000                 1005             


Leu Gln  Thr Thr Asn Thr Ser  Tyr Glu Glu Met Lys  Ala Glu Gln 
    1010                 1015                 1020             


Glu Asn  Gln Glu Leu Pro Asp  Glu Gly Thr Leu Glu  Glu Thr Leu 
    1025                 1030                 1035             


Thr Asn  Glu Thr Arg Asn Ala  Asp Asp Leu Glu Val  Ser Ser Asp 
    1040                 1045                 1050             


Ile Ile  Glu Ala Val Ala Ile  Ser Ser Asn Ser Phe  Ile Thr Thr 
    1055                 1060                 1065             


Gly Lys  Asp Ser Met Thr Val  Ser Glu Val Thr Ala  Ser Ile Ser 
    1070                 1075                 1080             


Ser Pro  Ser Glu Glu Asp Ala  Ser Glu Met Pro Glu  Phe Leu Asp 
    1085                 1090                 1095             


Lys Ser  Ile Val Glu Glu Glu  Glu Asp Asp Asp Tyr  Val Glu Leu 
    1100                 1105                 1110             


Lys Val  Glu Gly Ser Pro Thr  Glu Glu Ala Asn Leu  Pro Thr Glu 
    1115                 1120                 1125             


Leu Gln  Asp Asn Ser Leu Ser  Pro Ala Ala Ser Glu  Ala Gly Glu 
    1130                 1135                 1140             


Lys Leu  Asp Met Phe Gly Asn  Asp Asp Lys Leu Ile  Phe Gln Glu 
    1145                 1150                 1155             


Gly Lys  Pro Val Thr Glu Lys  Gln Thr Asp Thr Glu  Thr Gln Asp 
    1160                 1165                 1170             


Ser Lys  Asp Ser Gly Ile Gln  Thr Met Thr Ala Ser  Gly Ser Ser 
    1175                 1180                 1185             


Ala Met  Ser Pro Glu Thr Thr  Val Ser Gln Ile Ala  Val Glu Ser 
    1190                 1195                 1200             


Asp Leu  Gly Gln Met Leu Glu  Glu Gly Lys Lys Ala  Thr Asn Leu 
    1205                 1210                 1215             


Thr Arg  Glu Thr Lys Leu Ile  Asn Asp Cys His Gly  Ser Val Ser 
    1220                 1225                 1230             


Glu Ala  Ser Ser Glu Gln Lys  Ile Ala Lys Leu Asp  Val Ser Asn 
    1235                 1240                 1245             


Val Ala  Thr Asp Thr Glu Arg  Leu Glu Leu Lys Ala  Ser Pro Asn 
    1250                 1255                 1260             


Val Glu  Ala Pro Gln Pro His  Arg His Val Leu Glu  Ile Ser Arg 
    1265                 1270                 1275             


Gln His  Glu Gln Pro Gly Gln  Gly Ile Ala Pro Asp  Ala Val Asn 
    1280                 1285                 1290             


Gly Gln  Arg Arg Asp Ser Arg  Ser Thr Val Phe Arg  Ile Pro Glu 
    1295                 1300                 1305             


Phe Asn  Trp Ser Gln Met His  Gln Arg Leu Leu Thr  Asp Leu Leu 
    1310                 1315                 1320             


Phe Ser  Ile Glu Thr Asp Ile  Gln Met Trp Arg Ser  His Ser Thr 
    1325                 1330                 1335             


Lys Thr  Val Met Asp Phe Val  Asn Ser Ser Asp Asn  Val Ile Phe 
    1340                 1345                 1350             


Val His  Asn Thr Ile His Leu  Ile Ser Gln Val Met  Asp Asn Met 
    1355                 1360                 1365             


Val Met  Ala Cys Gly Gly Ile  Leu Pro Leu Leu Ser  Ala Ala Thr 
    1370                 1375                 1380             


Ser Ala  Thr His Glu Leu Glu  Asn Ile Glu Pro Thr  Gln Gly Leu 
    1385                 1390                 1395             


Ser Ile  Glu Ala Ser Val Thr  Phe Leu Gln Arg Leu  Ile Ser Leu 
    1400                 1405                 1410             


Val Asp  Val Leu Ile Phe Ala  Ser Ser Leu Gly Phe  Thr Glu Ile 
    1415                 1420                 1425             


Glu Ala  Glu Lys Ser Met Ser  Ser Gly Gly Ile Leu  Arg Gln Cys 
    1430                 1435                 1440             


Leu Arg  Leu Val Cys Ala Val  Ala Val Arg Asn Cys  Leu Glu Cys 
    1445                 1450                 1455             


Gln Gln  His Ser Gln Leu Lys  Thr Arg Gly Asp Lys  Ala Leu Lys 
    1460                 1465                 1470             


Pro Met  His Ser Leu Ile Pro  Leu Gly Lys Ser Ala  Ala Lys Ser 
    1475                 1480                 1485             


Pro Val  Asp Ile Val Thr Gly  Gly Ile Ser Pro Val  Arg Asp Leu 
    1490                 1495                 1500             


Asp Arg  Leu Leu Gln Asp Met  Asp Ile Asn Arg Leu  Arg Ala Val 
    1505                 1510                 1515             


Val Phe  Arg Asp Ile Glu Asp  Ser Lys Gln Ala Gln  Phe Leu Ala 
    1520                 1525                 1530             


Leu Ala  Val Val Tyr Phe Ile  Ser Val Leu Met Val  Ser Lys Tyr 
    1535                 1540                 1545             


Arg Asp  Ile Leu Glu Pro Gln  Asn Glu Arg His Ser  Gln Ser Cys 
    1550                 1555                 1560             


Thr Glu  Thr Gly Ser Glu Asn  Glu Asn Val Ser Leu  Ser Glu Ile 
    1565                 1570                 1575             


Thr Pro  Ala Ala Phe Ser Thr  Leu Thr Thr Ala Ser  Val Glu Glu 
    1580                 1585                 1590             


Ser Glu  Ser Thr Ser Ser Ala  Arg Arg Arg Asp Ser  Gly Ile Gly 
    1595                 1600                 1605             


Glu Glu  Thr Ala Thr Gly Leu  Gly Ser His Val Glu  Val Thr Pro 
    1610                 1615                 1620             


His Thr  Ala Pro Pro Gly Val  Ser Ala Gly Pro Asp  Ala Ile Ser 
    1625                 1630                 1635             


Glu Val  Leu Ser Thr Leu Ser  Leu Glu Val Asn Lys  Ser Pro Glu 
    1640                 1645                 1650             


Thr Lys  Asn Asp Arg Gly Asn  Asp Leu Asp Thr Lys  Ala Thr Pro 
    1655                 1660                 1665             


Ser Val  Ser Val Ser Lys Asn  Val Asn Val Lys Asp  Ile Leu Arg 
    1670                 1675                 1680             


Ser Leu  Val Asn Ile Pro Ala  Asp Gly Val Thr Val  Asp Pro Ala 
    1685                 1690                 1695             


Leu Leu  Pro Pro Ala Cys Leu  Gly Ala Leu Gly Asp  Leu Ser Val 
    1700                 1705                 1710             


Glu Gln  Pro Val Gln Phe Arg  Ser Phe Asp Arg Ser  Val Ile Val 
    1715                 1720                 1725             


Ala Ala  Lys Lys Ser Ala Val  Ser Pro Ser Thr Phe  Asn Thr Ser 
    1730                 1735                 1740             


Ile Pro  Thr Asn Ala Val Ser  Val Val Ser Ser Val  Asp Ser Ala 
    1745                 1750                 1755             


Gln Ala  Ser Asp Met Gly Gly  Glu Ser Pro Gly Ser  Arg Ser Ser 
    1760                 1765                 1770             


Asn Ala  Lys Leu Pro Ser Val  Pro Thr Val Asp Ser  Val Ser Gln 
    1775                 1780                 1785             


Asp Pro  Val Ser Asn Met Ser  Ile Thr Glu Arg Leu  Glu His Ala 
    1790                 1795                 1800             


Leu Glu  Lys Ala Ala Pro Leu  Leu Arg Glu Ile Phe  Val Asp Phe 
    1805                 1810                 1815             


Ala Pro  Phe Leu Ser Arg Thr  Leu Leu Gly Ser His  Gly Gln Glu 
    1820                 1825                 1830             


Leu Leu  Ile Glu Gly Thr Ser  Leu Val Cys Met Lys  Ser Ser Ser 
    1835                 1840                 1845             


Ser Val  Val Glu Leu Val Met  Leu Leu Cys Ser Gln  Glu Trp Gln 
    1850                 1855                 1860             


Asn Ser  Ile Gln Lys Asn Ala  Gly Leu Ala Phe Ile  Glu Leu Val 
    1865                 1870                 1875             


Asn Glu  Gly Arg Leu Leu Ser  Gln Thr Met Lys Asp  His Leu Val 
    1880                 1885                 1890             


Arg Val  Ala Asn Glu Ala Glu  Phe Ile Leu Ser Arg  Gln Arg Ala 
    1895                 1900                 1905             


Glu Asp  Ile His Arg His Ala  Glu Phe Glu Ser Leu  Cys Ala Gln 
    1910                 1915                 1920             


Tyr Ser  Ala Asp Lys Arg Glu  Asp Glu Lys Met Cys  Asp His Leu 
    1925                 1930                 1935             


Ile Arg  Ala Ala Lys Tyr Arg  Asp His Val Thr Ala  Thr Gln Leu 
    1940                 1945                 1950             


Ile Gln  Lys Ile Ile Asn Ile  Leu Thr Asp Lys His  Gly Ala Trp 
    1955                 1960                 1965             


Gly Asn  Ser Ala Val Ser Arg  Pro Leu Glu Phe Trp  Arg Leu Asp 
    1970                 1975                 1980             


Tyr Trp  Glu Asp Asp Leu Arg  Arg Arg Arg Arg Phe  Val Arg Asn 
    1985                 1990                 1995             


Pro Leu  Gly Ser Thr His Pro  Glu Ala Thr Leu Lys  Thr Ala Val 
    2000                 2005                 2010             


Glu His  Ala Thr Asp Glu Asp  Ile Leu Ala Lys Gly  Lys Gln Ser 
    2015                 2020                 2025             


Ile Arg  Ser Gln Ala Leu Gly  Asn Gln Asn Ser Glu  Asn Glu Ile 
    2030                 2035                 2040             


Leu Leu  Glu Gly Asp Asp Asp  Thr Leu Ser Ser Val  Asp Glu Lys 
    2045                 2050                 2055             


Asp Leu  Glu Asn Leu Ala Gly  Pro Val Ser Leu Ser  Thr Pro Ala 
    2060                 2065                 2070             


Gln Leu  Val Ala Pro Ser Val  Val Val Lys Gly Thr  Leu Ser Val 
    2075                 2080                 2085             


Thr Ser  Ser Glu Leu Tyr Phe  Glu Val Asp Glu Glu  Asp Pro Asn 
    2090                 2095                 2100             


Phe Lys  Lys Ile Asp Pro Lys  Ile Leu Ala Tyr Thr  Glu Gly Leu 
    2105                 2110                 2115             


His Gly  Lys Trp Leu Phe Thr  Glu Ile Arg Ser Ile  Phe Ser Arg 
    2120                 2125                 2130             


Arg Tyr  Leu Leu Gln Asn Thr  Ala Leu Glu Ile Phe  Met Ala Asn 
    2135                 2140                 2145             


Arg Val  Ala Val Met Phe Asn  Phe Pro Asp Pro Ala  Thr Val Lys 
    2150                 2155                 2160             


Lys Val  Val Asn Tyr Leu Pro  Arg Val Gly Val Gly  Thr Ser Phe 
    2165                 2170                 2175             


Gly Leu  Pro Gln Thr Arg Arg  Ile Ser Leu Ala Ser  Pro Arg Gln 
    2180                 2185                 2190             


Leu Phe  Lys Ala Ser Asn Met  Thr Gln Arg Trp Gln  His Arg Glu 
    2195                 2200                 2205             


Ile Ser  Asn Phe Glu Tyr Leu  Met Phe Leu Asn Thr  Ile Ala Gly 
    2210                 2215                 2220             


Arg Ser  Tyr Asn Asp Leu Asn  Gln Tyr Pro Val Phe  Pro Trp Val 
    2225                 2230                 2235             


Ile Thr  Asn Tyr Glu Ser Glu  Glu Leu Asp Leu Thr  Leu Pro Thr 
    2240                 2245                 2250             


Asn Phe  Arg Asp Leu Ser Lys  Pro Ile Gly Ala Leu  Asn Pro Lys 
    2255                 2260                 2265             


Arg Ala  Ala Phe Phe Ala Glu  Arg Tyr Glu Ser Trp  Glu Asp Asp 
    2270                 2275                 2280             


Gln Val  Pro Lys Phe His Tyr  Gly Thr His Tyr Ser  Thr Ala Ser 
    2285                 2290                 2295             


Phe Val  Leu Ala Trp Leu Leu  Arg Ile Glu Pro Phe  Thr Thr Tyr 
    2300                 2305                 2310             


Phe Leu  Asn Leu Gln Gly Gly  Lys Phe Asp His Ala  Asp Arg Thr 
    2315                 2320                 2325             


Phe Ser  Ser Ile Ser Arg Ala  Trp Arg Asn Ser Gln  Arg Asp Thr 
    2330                 2335                 2340             


Ser Asp  Ile Lys Glu Leu Ile  Pro Glu Phe Tyr Tyr  Leu Pro Glu 
    2345                 2350                 2355             


Met Phe  Val Asn Phe Asn Asn  Tyr Asn Leu Gly Val  Met Asp Asp 
    2360                 2365                 2370             


Gly Thr  Val Val Ser Asp Val  Glu Leu Pro Pro Trp  Ala Lys Thr 
    2375                 2380                 2385             


Ser Glu  Glu Phe Val His Ile  Asn Arg Leu Ala Leu  Glu Ser Glu 
    2390                 2395                 2400             


Phe Val  Ser Cys Gln Leu His  Gln Trp Ile Asp Leu  Ile Phe Gly 
    2405                 2410                 2415             


Tyr Lys  Gln Gln Gly Pro Glu  Ala Val Arg Ala Leu  Asn Val Phe 
    2420                 2425                 2430             


Tyr Tyr  Leu Thr Tyr Glu Gly  Ala Val Asn Leu Asn  Ser Ile Thr 
    2435                 2440                 2445             


Asp Pro  Val Leu Arg Glu Ala  Val Glu Ala Gln Ile  Arg Ser Phe 
    2450                 2455                 2460             


Gly Gln  Thr Pro Ser Gln Leu  Leu Ile Glu Pro His  Pro Pro Arg 
    2465                 2470                 2475             


Gly Ser  Ala Met Gln Val Ser  Pro Leu Met Phe Thr  Asp Lys Ala 
    2480                 2485                 2490             


Gln Gln  Asp Val Ile Met Val  Leu Lys Phe Pro Ser  Asn Ser Pro 
    2495                 2500                 2505             


Val Thr  His Val Ala Ala Asn  Thr Gln Pro Gly Leu  Ala Thr Pro 
    2510                 2515                 2520             


Ala Val  Ile Thr Val Thr Ala  Asn Arg Leu Phe Ala  Val Asn Lys 
    2525                 2530                 2535             


Trp His  Asn Leu Pro Ala His  Gln Gly Ala Val Gln  Asp Gln Pro 
    2540                 2545                 2550             


Tyr Gln  Leu Pro Val Glu Ile  Asp Pro Leu Ile Ala  Ser Asn Thr 
    2555                 2560                 2565             


Gly Met  His Arg Arg Gln Ile  Thr Asp Leu Leu Asp  Gln Ser Ile 
    2570                 2575                 2580             


Gln Val  His Ser Gln Cys Phe  Val Ile Thr Ser Asp  Asn Arg Tyr 
    2585                 2590                 2595             


Ile Leu  Val Cys Gly Phe Trp  Asp Lys Ser Phe Arg  Val Tyr Ser 
    2600                 2605                 2610             


Thr Asp  Thr Gly Arg Leu Ile  Gln Val Val Phe Gly  His Trp Asp 
    2615                 2620                 2625             


Val Val  Thr Cys Leu Ala Arg  Ser Glu Ser Tyr Ile  Gly Gly Asn 
    2630                 2635                 2640             


Cys Tyr  Ile Leu Ser Gly Ser  Arg Asp Ala Thr Leu  Leu Leu Trp 
    2645                 2650                 2655             


Tyr Trp  Asn Gly Lys Cys Ser  Gly Ile Gly Asp Asn  Pro Gly Ser 
    2660                 2665                 2670             


Glu Thr  Ala Ala Pro Arg Ala  Ile Leu Thr Gly His  Asp Tyr Glu 
    2675                 2680                 2685             


Val Thr  Cys Ala Ala Val Cys  Ala Glu Leu Gly Leu  Val Leu Ser 
    2690                 2695                 2700             


Gly Ser  Gln Glu Gly Pro Cys  Leu Ile His Ser Met  Asn Gly Asp 
    2705                 2710                 2715             


Leu Leu  Arg Thr Leu Glu Gly  Pro Glu Asn Cys Leu  Lys Pro Lys 
    2720                 2725                 2730             


Leu Ile  Gln Ala Ser Arg Glu  Gly His Cys Val Ile  Phe Tyr Glu 
    2735                 2740                 2745             


Asn Gly  Leu Phe Cys Thr Phe  Ser Val Asn Gly Lys  Leu Gln Ala 
    2750                 2755                 2760             


Thr Met  Glu Thr Asp Asp Asn  Ile Arg Ala Ile Gln  Leu Ser Arg 
    2765                 2770                 2775             


Asp Gly  Gln Tyr Leu Leu Thr  Gly Gly Asp Arg Gly  Val Val Val 
    2780                 2785                 2790             


Val Arg  Gln Val Ser Asp Leu  Lys Gln Leu Phe Ala  Tyr Pro Gly 
    2795                 2800                 2805             


Cys Asp  Ala Gly Ile Arg Ala  Met Ala Leu Ser Tyr  Asp Gln Arg 
    2810                 2815                 2820             


Cys Ile  Ile Ser Gly Met Ala  Ser Gly Ser Ile Val  Leu Phe Tyr 
    2825                 2830                 2835             


Asn Asp  Phe Asn Arg Trp His  His Glu Tyr Gln Thr  Arg Tyr 
    2840                 2845                 2850         


<210>  196
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  196

Met Asn Gln Glu Leu Leu Ser Val Gly Ser Lys Arg Arg Arg Thr Gly 
1               5                   10                  15      


Gly Ser Leu Arg Gly Asn Pro Ser Ser Ser Gln Val Asp Glu Glu Gln 
            20                  25                  30          


Met Asn Arg Val Val Glu Glu Glu Gln Gln Gln Gln Leu Arg Gln Gln 
        35                  40                  45              


Glu Glu Glu His Thr Ala Arg Asn Gly Glu Val Val Gly Val Glu Pro 
    50                  55                  60                  


Arg Pro Gly Gly Gln Asn Asp Ser Gln Gln Gly Gln Leu Glu Glu Asn 
65                  70                  75                  80  


Asn Asn Arg Phe Ile Ser Val Asp Glu Asp Ser Ser Gly Asn Gln Glu 
                85                  90                  95      


Glu Gln Glu Glu Asp Glu Glu His Ala Gly Glu Gln Asp Glu Glu Asp 
            100                 105                 110         


Glu Glu Glu Glu Glu Met Asp Gln Glu Ser Asp Asp Phe Asp Gln Ser 
        115                 120                 125             


Asp Asp Ser Ser Arg Glu Asp Glu His Thr His Thr Asn Ser Val Thr 
    130                 135                 140                 


Asn Ser Ser Ser Ile Val Asp Leu Pro Val His Gln Leu Ser Ser Pro 
145                 150                 155                 160 


Phe Tyr Thr Lys Thr Thr Lys Met Lys Arg Lys Leu Asp His Gly Ser 
                165                 170                 175     


Glu Val Arg Ser Phe Ser Leu Gly Lys Lys Pro Cys Lys Val Ser Glu 
            180                 185                 190         


Tyr Thr Ser Thr Thr Gly Leu Val Pro Cys Ser Ala Thr Pro Thr Thr 
        195                 200                 205             


Phe Gly Asp Leu Arg Ala Ala Asn Gly Gln Gly Gln Gln Arg Arg Arg 
    210                 215                 220                 


Ile Thr Ser Val Gln Pro Pro Thr Gly Leu Gln Glu Trp Leu Lys Met 
225                 230                 235                 240 


Phe Gln Ser Trp Ser Gly Pro Glu Lys Leu Leu Ala Leu Asp Glu Leu 
                245                 250                 255     


Ile Asp Ser Cys Glu Pro Thr Gln Val Lys His Met Met Gln Val Ile 
            260                 265                 270         


Glu Pro Gln Phe Gln Arg Asp Phe Ile Ser Leu Leu Pro Lys Glu Leu 
        275                 280                 285             


Ala Leu Tyr Val Leu Ser Phe Leu Glu Pro Lys Asp Leu Leu Gln Ala 
    290                 295                 300                 


Ala Gln Thr Cys Arg Tyr Trp Arg Ile Leu Ala Glu Asp Asn Leu Leu 
305                 310                 315                 320 


Trp Arg Glu Lys Cys Lys Glu Glu Gly Ile Asp Glu Pro Leu His Ile 
                325                 330                 335     


Lys Arg Arg Lys Val Ile Lys Pro Gly Phe Ile His Ser Pro Trp Lys 
            340                 345                 350         


Ser Ala Tyr Ile Arg Gln His Arg Ile Asp Thr Asn Trp Arg Arg Gly 
        355                 360                 365             


Glu Leu Lys Ser Pro Lys Val Leu Lys Gly His Asp Asp His Val Ile 
    370                 375                 380                 


Thr Cys Leu Gln Phe Cys Gly Asn Arg Ile Val Ser Gly Ser Asp Asp 
385                 390                 395                 400 


Asn Thr Leu Lys Val Trp Ser Ala Val Thr Gly Lys Cys Leu Arg Thr 
                405                 410                 415     


Leu Val Gly His Thr Gly Gly Val Trp Ser Ser Gln Met Arg Asp Asn 
            420                 425                 430         


Ile Ile Ile Ser Gly Ser Thr Asp Arg Thr Leu Lys Val Trp Asn Ala 
        435                 440                 445             


Glu Thr Gly Glu Cys Ile His Thr Leu Tyr Gly His Thr Ser Thr Val 
    450                 455                 460                 


Arg Cys Met His Leu His Glu Lys Arg Val Val Ser Gly Ser Arg Asp 
465                 470                 475                 480 


Ala Thr Leu Arg Val Trp Asp Ile Glu Thr Gly Gln Cys Leu His Val 
                485                 490                 495     


Leu Met Gly His Val Ala Ala Val Arg Cys Val Gln Tyr Asp Gly Arg 
            500                 505                 510         


Arg Val Val Ser Gly Ala Tyr Asp Phe Met Val Lys Val Trp Asp Pro 
        515                 520                 525             


Glu Thr Glu Thr Cys Leu His Thr Leu Gln Gly His Thr Asn Arg Val 
    530                 535                 540                 


Tyr Ser Leu Gln Phe Asp Gly Ile His Val Val Ser Gly Ser Leu Asp 
545                 550                 555                 560 


Thr Ser Ile Arg Val Trp Asp Val Glu Thr Gly Asn Cys Ile His Thr 
                565                 570                 575     


Leu Thr Gly His Gln Ser Leu Thr Ser Gly Met Glu Leu Lys Asp Asn 
            580                 585                 590         


Ile Leu Val Ser Gly Asn Ala Asp Ser Thr Val Lys Ile Trp Asp Ile 
        595                 600                 605             


Lys Thr Gly Gln Cys Leu Gln Thr Leu Gln Gly Pro Asn Lys His Gln 
    610                 615                 620                 


Ser Ala Val Thr Cys Leu Gln Phe Asn Lys Asn Phe Val Ile Thr Ser 
625                 630                 635                 640 


Ser Asp Asp Gly Thr Val Lys Leu Trp Asp Leu Lys Thr Gly Glu Phe 
                645                 650                 655     


Ile Arg Asn Leu Val Thr Leu Glu Ser Gly Gly Ser Gly Gly Val Val 
            660                 665                 670         


Trp Arg Ile Arg Ala Ser Asn Thr Lys Leu Val Cys Ala Val Gly Ser 
        675                 680                 685             


Arg Asn Gly Thr Glu Glu Thr Lys Leu Leu Val Leu Asp Phe Asp Val 
    690                 695                 700                 


Asp Met Lys 
705         


<210>  197
<211>  589
<212>  PRT
<213>  Homo sapiens

<400>  197

Met Ser Lys Pro Gly Lys Pro Thr Leu Asn His Gly Leu Val Pro Val 
1               5                   10                  15      


Asp Leu Lys Ser Ala Lys Glu Pro Leu Pro His Gln Thr Val Met Lys 
            20                  25                  30          


Ile Phe Ser Ile Ser Ile Ile Ala Gln Gly Leu Pro Phe Cys Arg Arg 
        35                  40                  45              


Arg Met Lys Arg Lys Leu Asp His Gly Ser Glu Val Arg Ser Phe Ser 
    50                  55                  60                  


Leu Gly Lys Lys Pro Cys Lys Val Ser Glu Tyr Thr Ser Thr Thr Gly 
65                  70                  75                  80  


Leu Val Pro Cys Ser Ala Thr Pro Thr Thr Phe Gly Asp Leu Arg Ala 
                85                  90                  95      


Ala Asn Gly Gln Gly Gln Gln Arg Arg Arg Ile Thr Ser Val Gln Pro 
            100                 105                 110         


Pro Thr Gly Leu Gln Glu Trp Leu Lys Met Phe Gln Ser Trp Ser Gly 
        115                 120                 125             


Pro Glu Lys Leu Leu Ala Leu Asp Glu Leu Ile Asp Ser Cys Glu Pro 
    130                 135                 140                 


Thr Gln Val Lys His Met Met Gln Val Ile Glu Pro Gln Phe Gln Arg 
145                 150                 155                 160 


Asp Phe Ile Ser Leu Leu Pro Lys Glu Leu Ala Leu Tyr Val Leu Ser 
                165                 170                 175     


Phe Leu Glu Pro Lys Asp Leu Leu Gln Ala Ala Gln Thr Cys Arg Tyr 
            180                 185                 190         


Trp Arg Ile Leu Ala Glu Asp Asn Leu Leu Trp Arg Glu Lys Cys Lys 
        195                 200                 205             


Glu Glu Gly Ile Asp Glu Pro Leu His Ile Lys Arg Arg Lys Val Ile 
    210                 215                 220                 


Lys Pro Gly Phe Ile His Ser Pro Trp Lys Ser Ala Tyr Ile Arg Gln 
225                 230                 235                 240 


His Arg Ile Asp Thr Asn Trp Arg Arg Gly Glu Leu Lys Ser Pro Lys 
                245                 250                 255     


Val Leu Lys Gly His Asp Asp His Val Ile Thr Cys Leu Gln Phe Cys 
            260                 265                 270         


Gly Asn Arg Ile Val Ser Gly Ser Asp Asp Asn Thr Leu Lys Val Trp 
        275                 280                 285             


Ser Ala Val Thr Gly Lys Cys Leu Arg Thr Leu Val Gly His Thr Gly 
    290                 295                 300                 


Gly Val Trp Ser Ser Gln Met Arg Asp Asn Ile Ile Ile Ser Gly Ser 
305                 310                 315                 320 


Thr Asp Arg Thr Leu Lys Val Trp Asn Ala Glu Thr Gly Glu Cys Ile 
                325                 330                 335     


His Thr Leu Tyr Gly His Thr Ser Thr Val Arg Cys Met His Leu His 
            340                 345                 350         


Glu Lys Arg Val Val Ser Gly Ser Arg Asp Ala Thr Leu Arg Val Trp 
        355                 360                 365             


Asp Ile Glu Thr Gly Gln Cys Leu His Val Leu Met Gly His Val Ala 
    370                 375                 380                 


Ala Val Arg Cys Val Gln Tyr Asp Gly Arg Arg Val Val Ser Gly Ala 
385                 390                 395                 400 


Tyr Asp Phe Met Val Lys Val Trp Asp Pro Glu Thr Glu Thr Cys Leu 
                405                 410                 415     


His Thr Leu Gln Gly His Thr Asn Arg Val Tyr Ser Leu Gln Phe Asp 
            420                 425                 430         


Gly Ile His Val Val Ser Gly Ser Leu Asp Thr Ser Ile Arg Val Trp 
        435                 440                 445             


Asp Val Glu Thr Gly Asn Cys Ile His Thr Leu Thr Gly His Gln Ser 
    450                 455                 460                 


Leu Thr Ser Gly Met Glu Leu Lys Asp Asn Ile Leu Val Ser Gly Asn 
465                 470                 475                 480 


Ala Asp Ser Thr Val Lys Ile Trp Asp Ile Lys Thr Gly Gln Cys Leu 
                485                 490                 495     


Gln Thr Leu Gln Gly Pro Asn Lys His Gln Ser Ala Val Thr Cys Leu 
            500                 505                 510         


Gln Phe Asn Lys Asn Phe Val Ile Thr Ser Ser Asp Asp Gly Thr Val 
        515                 520                 525             


Lys Leu Trp Asp Leu Lys Thr Gly Glu Phe Ile Arg Asn Leu Val Thr 
    530                 535                 540                 


Leu Glu Ser Gly Gly Ser Gly Gly Val Val Trp Arg Ile Arg Ala Ser 
545                 550                 555                 560 


Asn Thr Lys Leu Val Cys Ala Val Gly Ser Arg Asn Gly Thr Glu Glu 
                565                 570                 575     


Thr Lys Leu Leu Val Leu Asp Phe Asp Val Asp Met Lys 
            580                 585                 


<210>  198
<211>  627
<212>  PRT
<213>  Homo sapiens

<400>  198

Met Cys Val Pro Arg Ser Gly Leu Ile Leu Ser Cys Ile Cys Leu Tyr 
1               5                   10                  15      


Cys Gly Val Leu Leu Pro Val Leu Leu Pro Asn Leu Pro Phe Leu Thr 
            20                  25                  30          


Cys Leu Ser Met Ser Thr Leu Glu Ser Val Thr Tyr Leu Pro Glu Lys 
        35                  40                  45              


Gly Leu Tyr Cys Gln Arg Leu Pro Ser Ser Arg Thr His Gly Gly Thr 
    50                  55                  60                  


Glu Ser Leu Lys Gly Lys Asn Thr Glu Asn Met Gly Phe Tyr Gly Thr 
65                  70                  75                  80  


Leu Lys Met Ile Phe Tyr Lys Met Lys Arg Lys Leu Asp His Gly Ser 
                85                  90                  95      


Glu Val Arg Ser Phe Ser Leu Gly Lys Lys Pro Cys Lys Val Ser Glu 
            100                 105                 110         


Tyr Thr Ser Thr Thr Gly Leu Val Pro Cys Ser Ala Thr Pro Thr Thr 
        115                 120                 125             


Phe Gly Asp Leu Arg Ala Ala Asn Gly Gln Gly Gln Gln Arg Arg Arg 
    130                 135                 140                 


Ile Thr Ser Val Gln Pro Pro Thr Gly Leu Gln Glu Trp Leu Lys Met 
145                 150                 155                 160 


Phe Gln Ser Trp Ser Gly Pro Glu Lys Leu Leu Ala Leu Asp Glu Leu 
                165                 170                 175     


Ile Asp Ser Cys Glu Pro Thr Gln Val Lys His Met Met Gln Val Ile 
            180                 185                 190         


Glu Pro Gln Phe Gln Arg Asp Phe Ile Ser Leu Leu Pro Lys Glu Leu 
        195                 200                 205             


Ala Leu Tyr Val Leu Ser Phe Leu Glu Pro Lys Asp Leu Leu Gln Ala 
    210                 215                 220                 


Ala Gln Thr Cys Arg Tyr Trp Arg Ile Leu Ala Glu Asp Asn Leu Leu 
225                 230                 235                 240 


Trp Arg Glu Lys Cys Lys Glu Glu Gly Ile Asp Glu Pro Leu His Ile 
                245                 250                 255     


Lys Arg Arg Lys Val Ile Lys Pro Gly Phe Ile His Ser Pro Trp Lys 
            260                 265                 270         


Ser Ala Tyr Ile Arg Gln His Arg Ile Asp Thr Asn Trp Arg Arg Gly 
        275                 280                 285             


Glu Leu Lys Ser Pro Lys Val Leu Lys Gly His Asp Asp His Val Ile 
    290                 295                 300                 


Thr Cys Leu Gln Phe Cys Gly Asn Arg Ile Val Ser Gly Ser Asp Asp 
305                 310                 315                 320 


Asn Thr Leu Lys Val Trp Ser Ala Val Thr Gly Lys Cys Leu Arg Thr 
                325                 330                 335     


Leu Val Gly His Thr Gly Gly Val Trp Ser Ser Gln Met Arg Asp Asn 
            340                 345                 350         


Ile Ile Ile Ser Gly Ser Thr Asp Arg Thr Leu Lys Val Trp Asn Ala 
        355                 360                 365             


Glu Thr Gly Glu Cys Ile His Thr Leu Tyr Gly His Thr Ser Thr Val 
    370                 375                 380                 


Arg Cys Met His Leu His Glu Lys Arg Val Val Ser Gly Ser Arg Asp 
385                 390                 395                 400 


Ala Thr Leu Arg Val Trp Asp Ile Glu Thr Gly Gln Cys Leu His Val 
                405                 410                 415     


Leu Met Gly His Val Ala Ala Val Arg Cys Val Gln Tyr Asp Gly Arg 
            420                 425                 430         


Arg Val Val Ser Gly Ala Tyr Asp Phe Met Val Lys Val Trp Asp Pro 
        435                 440                 445             


Glu Thr Glu Thr Cys Leu His Thr Leu Gln Gly His Thr Asn Arg Val 
    450                 455                 460                 


Tyr Ser Leu Gln Phe Asp Gly Ile His Val Val Ser Gly Ser Leu Asp 
465                 470                 475                 480 


Thr Ser Ile Arg Val Trp Asp Val Glu Thr Gly Asn Cys Ile His Thr 
                485                 490                 495     


Leu Thr Gly His Gln Ser Leu Thr Ser Gly Met Glu Leu Lys Asp Asn 
            500                 505                 510         


Ile Leu Val Ser Gly Asn Ala Asp Ser Thr Val Lys Ile Trp Asp Ile 
        515                 520                 525             


Lys Thr Gly Gln Cys Leu Gln Thr Leu Gln Gly Pro Asn Lys His Gln 
    530                 535                 540                 


Ser Ala Val Thr Cys Leu Gln Phe Asn Lys Asn Phe Val Ile Thr Ser 
545                 550                 555                 560 


Ser Asp Asp Gly Thr Val Lys Leu Trp Asp Leu Lys Thr Gly Glu Phe 
                565                 570                 575     


Ile Arg Asn Leu Val Thr Leu Glu Ser Gly Gly Ser Gly Gly Val Val 
            580                 585                 590         


Trp Arg Ile Arg Ala Ser Asn Thr Lys Leu Val Cys Ala Val Gly Ser 
        595                 600                 605             


Arg Asn Gly Thr Glu Glu Thr Lys Leu Leu Val Leu Asp Phe Asp Val 
    610                 615                 620                 


Asp Met Lys 
625         


<210>  199
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  199

Met Asn Gln Glu Leu Leu Ser Val Gly Ser Lys Arg Arg Arg Thr Gly 
1               5                   10                  15      


Gly Ser Leu Arg Gly Asn Pro Ser Ser Ser Gln Val Asp Glu Glu Gln 
            20                  25                  30          


Met Asn Arg Val Val Glu Glu Glu Gln Gln Gln Gln Leu Arg Gln Gln 
        35                  40                  45              


Glu Glu Glu His Thr Ala Arg Asn Gly Glu Val Val Gly Val Glu Pro 
    50                  55                  60                  


Arg Pro Gly Gly Gln Asn 
65                  70  


<210>  200
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  200

Met Asn Gln Glu Leu Leu Ser Val Gly Ser Lys Arg Arg Arg Thr Gly 
1               5                   10                  15      


Gly Ser Leu Arg Gly Asn Pro Ser Ser Ser Gln Val Asp Glu Glu Gln 
            20                  25                  30          


Met Asn Arg Val Val Glu Glu Glu Gln Gln Gln Gln Leu Arg Gln Gln 
        35                  40                  45              


Glu Glu Glu His Thr Ala Arg Asn Gly Glu Val Val Gly Val Glu Pro 
    50                  55                  60                  


Arg Pro Gly Gly Gln Asn Asp Ser Gln Gln Gly Gln Leu Glu Glu Asn 
65                  70                  75                  80  


Asn Asn Arg Phe Ile Ser Val Asp Glu Asp Ser Ser Gly Asn Gln Glu 
                85                  90                  95      


Glu Gln Glu Glu Asp Glu Glu His Ala Gly Glu Gln Asp Glu Glu Asp 
            100                 105                 110         


Glu Glu Glu Glu Glu Met Asp Gln Glu Ser Asp Asp Phe Asp Gln Ser 
        115                 120                 125             


Asp Asp Ser Ser Arg Glu Asp Glu His Thr His Thr Asn Ser Val Thr 
    130                 135                 140                 


Asn Ser Ser Ser Ile Val Asp Leu Pro Val His Gln Leu Ser 
145                 150                 155             


<210>  201
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  201

Met Asn Gln Glu Leu Leu Ser Val Gly Ser Lys Arg Arg Arg Thr Gly 
1               5                   10                  15      


Gly Ser Leu Arg Gly Asn Pro Ser Ser Ser Gln Val Asp Glu Glu Gln 
            20                  25                  30          


Met Asn Arg Val Val Glu Glu Glu Gln Gln Gln Gln Leu Arg Gln Gln 
        35                  40                  45              


Glu Glu Glu His Thr Ala Arg Asn Gly Glu Val Val Gly Val Glu Pro 
    50                  55                  60                  


Arg Pro Gly Gly Gln Asn Asp Ser Gln Gln Gly Gln Leu Glu Glu Asn 
65                  70                  75                  80  


Asn Asn Arg Phe Ile Ser Val Asp Glu Asp Ser Ser Gly Asn Gln Glu 
                85                  90                  95      


Glu Gln Glu Glu Asp Glu Glu His Ala Gly Glu Gln Asp Glu Glu Asp 
            100                 105                 110         


Glu Glu Glu Glu Glu Met Asp Gln Glu Ser Asp Asp Phe Asp Gln Ser 
        115                 120                 125             


Asp Asp Ser Ser Arg Glu Asp Glu His Thr His Thr Asn Ser Val Thr 
    130                 135                 140                 


Asn Ser Ser Ser Ile Val Asp Leu Pro Val His Gln Leu Ser Ser Pro 
145                 150                 155                 160 


Phe Tyr Thr Lys Thr Thr Lys Val Ser Ile Phe Asn Ile Leu Leu Thr 
                165                 170                 175     


<210>  202
<211>  890
<212>  PRT
<213>  Homo sapiens

<400>  202

Met Ser Ala Asn Asn Ser Pro Pro Ser Ala Gln Lys Ser Val Leu Pro 
1               5                   10                  15      


Thr Ala Ile Pro Ala Val Leu Pro Ala Ala Ser Pro Cys Ser Ser Pro 
            20                  25                  30          


Lys Thr Gly Leu Ser Ala Arg Leu Ser Asn Gly Ser Phe Ser Ala Pro 
        35                  40                  45              


Ser Leu Thr Asn Ser Arg Gly Ser Val His Thr Val Ser Phe Leu Leu 
    50                  55                  60                  


Gln Ile Gly Leu Thr Arg Glu Ser Val Thr Ile Glu Ala Gln Glu Leu 
65                  70                  75                  80  


Ser Leu Ser Ala Val Lys Asp Leu Val Cys Ser Ile Val Tyr Gln Lys 
                85                  90                  95      


Phe Pro Glu Cys Gly Phe Phe Gly Met Tyr Asp Lys Ile Leu Leu Phe 
            100                 105                 110         


Arg His Asp Met Asn Ser Glu Asn Ile Leu Gln Leu Ile Thr Ser Ala 
        115                 120                 125             


Asp Glu Ile His Glu Gly Asp Leu Val Glu Val Val Leu Ser Ala Leu 
    130                 135                 140                 


Ala Thr Val Glu Asp Phe Gln Ile Arg Pro His Thr Leu Tyr Val His 
145                 150                 155                 160 


Ser Tyr Lys Ala Pro Thr Phe Cys Asp Tyr Cys Gly Glu Met Leu Trp 
                165                 170                 175     


Gly Leu Val Arg Gln Gly Leu Lys Cys Glu Gly Cys Gly Leu Asn Tyr 
            180                 185                 190         


His Lys Arg Cys Ala Phe Lys Ile Pro Asn Asn Cys Ser Gly Val Arg 
        195                 200                 205             


Lys Arg Arg Leu Ser Asn Val Ser Leu Pro Gly Pro Gly Leu Ser Val 
    210                 215                 220                 


Pro Arg Pro Leu Gln Pro Glu Tyr Val Ala Leu Pro Ser Glu Glu Ser 
225                 230                 235                 240 


His Val His Gln Glu Pro Ser Lys Arg Ile Pro Ser Trp Ser Gly Arg 
                245                 250                 255     


Pro Ile Trp Met Glu Lys Met Val Met Cys Arg Val Lys Val Pro His 
            260                 265                 270         


Thr Phe Ala Val His Ser Tyr Thr Arg Pro Thr Ile Cys Gln Tyr Cys 
        275                 280                 285             


Lys Arg Leu Leu Lys Gly Leu Phe Arg Gln Gly Met Gln Cys Lys Asp 
    290                 295                 300                 


Cys Lys Phe Asn Cys His Lys Arg Cys Ala Ser Lys Val Pro Arg Asp 
305                 310                 315                 320 


Cys Leu Gly Glu Val Thr Phe Asn Gly Glu Pro Ser Ser Leu Gly Thr 
                325                 330                 335     


Asp Thr Asp Ile Pro Met Asp Ile Asp Asn Asn Asp Ile Asn Ser Asp 
            340                 345                 350         


Ser Ser Arg Gly Leu Asp Asp Thr Glu Glu Pro Ser Pro Pro Glu Asp 
        355                 360                 365             


Lys Met Phe Phe Leu Asp Pro Ser Asp Leu Asp Val Glu Arg Asp Glu 
    370                 375                 380                 


Glu Ala Val Lys Thr Ile Ser Pro Ser Thr Ser Asn Asn Ile Pro Leu 
385                 390                 395                 400 


Met Arg Val Val Gln Ser Ile Lys His Thr Lys Arg Lys Ser Ser Thr 
                405                 410                 415     


Met Val Lys Glu Gly Trp Met Val His Tyr Thr Ser Arg Asp Asn Leu 
            420                 425                 430         


Arg Lys Arg His Tyr Trp Arg Leu Asp Ser Lys Cys Leu Thr Leu Phe 
        435                 440                 445             


Gln Asn Glu Ser Gly Ser Lys Tyr Tyr Lys Glu Ile Pro Leu Ser Glu 
    450                 455                 460                 


Ile Leu Arg Ile Ser Ser Pro Arg Asp Phe Thr Asn Ile Ser Gln Gly 
465                 470                 475                 480 


Ser Asn Pro His Cys Phe Glu Ile Ile Thr Asp Thr Met Val Tyr Phe 
                485                 490                 495     


Val Gly Glu Asn Asn Gly Asp Ser Ser His Asn Pro Val Leu Ala Ala 
            500                 505                 510         


Thr Gly Val Gly Leu Asp Val Ala Gln Ser Trp Glu Lys Ala Ile Arg 
        515                 520                 525             


Gln Ala Leu Met Pro Val Thr Pro Gln Ala Ser Val Cys Thr Ser Pro 
    530                 535                 540                 


Gly Gln Gly Lys Asp His Lys Asp Leu Ser Thr Ser Ile Ser Val Ser 
545                 550                 555                 560 


Asn Cys Gln Ile Gln Glu Asn Val Asp Ile Ser Thr Val Tyr Gln Ile 
                565                 570                 575     


Phe Ala Asp Glu Val Leu Gly Ser Gly Gln Phe Gly Ile Val Tyr Gly 
            580                 585                 590         


Gly Lys His Arg Lys Thr Gly Arg Asp Val Ala Ile Lys Val Ile Asp 
        595                 600                 605             


Lys Met Arg Phe Pro Thr Lys Gln Glu Ser Gln Leu Arg Asn Glu Val 
    610                 615                 620                 


Ala Ile Leu Gln Asn Leu His His Pro Gly Ile Val Asn Leu Glu Cys 
625                 630                 635                 640 


Met Phe Glu Thr Pro Glu Arg Val Phe Val Val Met Glu Lys Leu His 
                645                 650                 655     


Gly Asp Met Leu Glu Met Ile Leu Ser Ser Glu Lys Ser Arg Leu Pro 
            660                 665                 670         


Glu Arg Ile Thr Lys Phe Met Val Thr Gln Ile Leu Val Ala Leu Arg 
        675                 680                 685             


Asn Leu His Phe Lys Asn Ile Val His Cys Asp Leu Lys Pro Glu Asn 
    690                 695                 700                 


Val Leu Leu Ala Ser Ala Glu Pro Phe Pro Gln Val Lys Leu Cys Asp 
705                 710                 715                 720 


Phe Gly Phe Ala Arg Ile Ile Gly Glu Lys Ser Phe Arg Arg Ser Val 
                725                 730                 735     


Val Gly Thr Pro Ala Tyr Leu Ala Pro Glu Val Leu Arg Ser Lys Gly 
            740                 745                 750         


Tyr Asn Arg Ser Leu Asp Met Trp Ser Val Gly Val Ile Ile Tyr Val 
        755                 760                 765             


Ser Leu Ser Gly Thr Phe Pro Phe Asn Glu Asp Glu Asp Ile Asn Asp 
    770                 775                 780                 


Gln Ile Gln Asn Ala Ala Phe Met Tyr Pro Pro Asn Pro Trp Arg Glu 
785                 790                 795                 800 


Ile Ser Gly Glu Ala Ile Asp Leu Ile Asn Asn Leu Leu Gln Val Lys 
                805                 810                 815     


Met Arg Lys Arg Tyr Ser Val Asp Lys Ser Leu Ser His Pro Trp Leu 
            820                 825                 830         


Gln Asp Tyr Gln Thr Trp Leu Asp Leu Arg Glu Phe Glu Thr Arg Ile 
        835                 840                 845             


Gly Glu Arg Tyr Ile Thr His Glu Ser Asp Asp Ala Arg Trp Glu Ile 
    850                 855                 860                 


His Ala Tyr Thr His Asn Leu Val Tyr Pro Lys His Phe Ile Met Ala 
865                 870                 875                 880 


Pro Asn Pro Asp Asp Met Glu Glu Asp Pro 
                885                 890 


<210>  203
<211>  185
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  203

Xaa Thr Ser Ile Ser Val Ser Asn Cys Gln Ile Gln Glu Asn Val Asp 
1               5                   10                  15      


Ile Ser Thr Val Tyr Gln Ile Phe Ala Asp Glu Val Leu Gly Ser Gly 
            20                  25                  30          


Gln Phe Gly Ile Val Tyr Gly Gly Lys His Arg Lys Thr Gly Arg Asp 
        35                  40                  45              


Val Ala Ile Lys Val Ile Asp Lys Met Arg Phe Pro Thr Lys Gln Glu 
    50                  55                  60                  


Ser Gln Leu Arg Asn Glu Val Ala Ile Leu Gln Ile Leu Val Ala Leu 
65                  70                  75                  80  


Arg Asn Leu His Phe Lys Asn Ile Val His Cys Asp Leu Lys Pro Glu 
                85                  90                  95      


Asn Val Leu Leu Ala Ser Ala Glu Pro Phe Pro Gln Val Lys Leu Cys 
            100                 105                 110         


Asp Phe Gly Phe Ala Arg Ile Ile Gly Glu Lys Ser Phe Arg Arg Ser 
        115                 120                 125             


Val Val Gly Thr Pro Ala Tyr Leu Ala Pro Glu Val Leu Arg Ser Lys 
    130                 135                 140                 


Gly Tyr Asn Arg Ser Leu Asp Met Trp Ser Val Gly Val Ile Ile Tyr 
145                 150                 155                 160 


Val Ser Leu Ser Gly Thr Phe Pro Phe Asn Glu Asp Glu Asp Ile Asn 
                165                 170                 175     


Asp Gln Ile Gln Asn Ala Ala Phe Met 
            180                 185 


<210>  204
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  204

Thr Asp Thr Met Val Tyr Phe Val Gly Glu Asn Asn Gly Asp Ser Ser 
1               5                   10                  15      


His Asn Pro Val Leu Ala Ala Thr Gly Val Gly Leu Asp Val Ala Gln 
            20                  25                  30          


Ser Trp Glu Lys Ala Ile Arg Gln Ala Leu Met Pro Val Thr Pro Gln 
        35                  40                  45              


Ala Ser Val Cys Thr Ser Pro Gly Gln Gly Lys Asp His Lys Asp Leu 
    50                  55                  60                  


Ser Thr Ser Ile Ser Val Ser Asn Cys Gln Ile Gln Glu Asn Val Asp 
65                  70                  75                  80  


Ile Ser Thr Val Tyr Gln Ile Phe Ala Asp Glu Val Leu Gly Ser Gly 
                85                  90                  95      


Gln Phe Gly Ile Val Tyr Gly Asp Leu Ser Val Leu Arg Val Val Thr 
            100                 105                 110         


Ser Leu Glu Asp Phe Leu Ser Ser Glu Glu Gln Arg Thr Val Arg Gly 
        115                 120                 125             


Lys His Arg Lys Thr Gly Arg Asp Val Ala Ile Lys Val Ile Asp Lys 
    130                 135                 140                 


Met Arg Phe Pro Thr Lys Gln Glu Ser Gln Leu Arg Asn Glu Val Ala 
145                 150                 155                 160 


Ile Leu Gln Asn Leu His His Pro Gly Ile Val Asn Leu 
                165                 170             


<210>  205
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  205

Met Tyr Asp Lys Ile Leu Leu Phe Arg His Asp Met Asn Ser Glu Asn 
1               5                   10                  15      


Ile Leu Gln Leu Ile Thr Ser Ala Asp Glu Ile His Glu Gly Asp Leu 
            20                  25                  30          


Val Glu Val Val Leu Ser Ala Leu Ala Thr Val Glu Asp Phe Gln Ile 
        35                  40                  45              


Arg Pro His Thr Leu Tyr Val His Ser Tyr Lys Ala Pro Thr Phe Cys 
    50                  55                  60                  


Asp Tyr Cys Gly Glu Met Leu Trp Gly Leu Val Arg Gln Gly Leu Lys 
65                  70                  75                  80  


Cys Glu Gly Cys Gly Leu Asn Tyr His Lys Arg Cys Ala Phe Lys Ile 
                85                  90                  95      


Pro Asn Asn Cys Ser Gly Val Arg Lys Arg Arg Leu Ser Asn Val Ser 
            100                 105                 110         


Leu Pro Gly Pro Gly Leu Ser Val Pro Arg Pro Leu Gln Pro Glu Tyr 
        115                 120                 125             


Val Ala Leu Pro Ser Glu Glu Ser His Val His Gln Glu Pro Ser Lys 
    130                 135                 140                 


Arg Ile Pro Ser Trp Ser Gly Arg Pro Ile Trp Met Glu Lys Met Val 
145                 150                 155                 160 


Met Cys Arg Val Lys Val Pro His Thr Phe Ala Val His Ser Tyr Thr 
                165                 170                 175     


Arg Pro Thr Ile Cys 
            180     


<210>  206
<211>  642
<212>  PRT
<213>  Homo sapiens

<400>  206

Met Ala Ala Ser Arg Lys Pro Pro Arg Val Arg Val Asn His Gln Asp 
1               5                   10                  15      


Phe Gln Leu Arg Asn Leu Arg Ile Ile Glu Pro Asn Glu Val Thr His 
            20                  25                  30          


Ser Gly Asp Thr Gly Val Glu Thr Asp Gly Arg Met Pro Pro Lys Val 
        35                  40                  45              


Thr Ser Glu Leu Leu Arg Gln Leu Arg Gln Ala Met Arg Asn Ser Glu 
    50                  55                  60                  


Tyr Val Thr Glu Pro Ile Gln Ala Tyr Ile Ile Pro Ser Gly Asp Ala 
65                  70                  75                  80  


His Gln Ser Glu Tyr Ile Ala Pro Cys Asp Cys Arg Arg Ala Phe Val 
                85                  90                  95      


Ser Gly Phe Asp Gly Ser Ala Gly Thr Ala Ile Ile Thr Glu Glu His 
            100                 105                 110         


Ala Ala Met Trp Thr Asp Gly Arg Tyr Phe Leu Gln Ala Ala Lys Gln 
        115                 120                 125             


Met Asp Ser Asn Trp Thr Leu Met Lys Met Gly Leu Lys Asp Thr Pro 
    130                 135                 140                 


Thr Gln Glu Asp Trp Leu Val Ser Val Leu Pro Glu Gly Ser Arg Val 
145                 150                 155                 160 


Gly Val Asp Pro Leu Ile Ile Pro Thr Asp Tyr Trp Lys Lys Met Ala 
                165                 170                 175     


Lys Val Leu Arg Ser Ala Gly His His Leu Ile Pro Val Lys Glu Asn 
            180                 185                 190         


Leu Val Asp Lys Ile Trp Thr Asp Arg Pro Glu Arg Pro Cys Lys Pro 
        195                 200                 205             


Leu Leu Thr Leu Gly Leu Asp Tyr Thr Gly Ile Ser Trp Lys Asp Lys 
    210                 215                 220                 


Val Ala Asp Leu Arg Leu Lys Met Ala Glu Arg Asn Val Met Trp Phe 
225                 230                 235                 240 


Val Val Thr Ala Leu Asp Glu Ile Ala Trp Leu Phe Asn Leu Arg Gly 
                245                 250                 255     


Ser Asp Val Glu His Asn Pro Val Phe Phe Ser Tyr Ala Ile Ile Gly 
            260                 265                 270         


Leu Glu Thr Ile Met Leu Phe Ile Asp Gly Asp Arg Ile Asp Ala Pro 
        275                 280                 285             


Ser Val Lys Glu His Leu Leu Leu Asp Leu Gly Leu Glu Ala Glu Tyr 
    290                 295                 300                 


Arg Ile Gln Val His Pro Tyr Lys Ser Ile Leu Ser Glu Leu Lys Ala 
305                 310                 315                 320 


Leu Cys Ala Asp Leu Ser Pro Arg Glu Lys Val Trp Val Ser Asp Lys 
                325                 330                 335     


Ala Ser Tyr Ala Val Ser Glu Thr Ile Pro Lys Asp His Arg Cys Cys 
            340                 345                 350         


Met Pro Tyr Thr Pro Ile Cys Ile Ala Lys Ala Val Lys Asn Ser Ala 
        355                 360                 365             


Glu Ser Glu Gly Met Arg Arg Ala His Ile Lys Asp Ala Val Ala Leu 
    370                 375                 380                 


Cys Glu Leu Phe Asn Trp Leu Glu Lys Glu Val Pro Lys Gly Gly Val 
385                 390                 395                 400 


Thr Glu Ile Ser Ala Ala Asp Lys Ala Glu Glu Phe Arg Arg Gln Gln 
                405                 410                 415     


Ala Asp Phe Val Asp Leu Ser Phe Pro Thr Ile Ser Ser Thr Gly Pro 
            420                 425                 430         


Asn Gly Ala Ile Ile His Tyr Ala Asp Gly Thr Thr Asp Val Thr Arg 
        435                 440                 445             


Thr Met His Phe Gly Thr Pro Thr Ala Tyr Glu Lys Glu Cys Phe Thr 
    450                 455                 460                 


Tyr Val Leu Lys Gly His Ile Ala Val Ser Ala Ala Val Phe Pro Thr 
465                 470                 475                 480 


Gly Thr Lys Gly His Leu Leu Asp Ser Phe Ala Arg Ser Ala Leu Trp 
                485                 490                 495     


Asp Ser Gly Leu Asp Tyr Leu His Gly Thr Gly His Gly Val Gly Ser 
            500                 505                 510         


Phe Leu Asn Val His Glu Gly Pro Cys Gly Ile Ser Tyr Lys Thr Phe 
        515                 520                 525             


Ser Asp Glu Pro Leu Glu Ala Gly Met Ile Val Thr Asp Glu Pro Gly 
    530                 535                 540                 


Tyr Tyr Glu Asp Gly Ala Phe Gly Ile Arg Ile Glu Asn Val Val Leu 
545                 550                 555                 560 


Val Val Pro Val Lys Thr Lys Tyr Asn Phe Asn Asn Arg Gly Ser Leu 
                565                 570                 575     


Thr Phe Glu Pro Leu Thr Leu Val Pro Ile Gln Thr Lys Met Ile Asp 
            580                 585                 590         


Val Asp Ser Leu Thr Asp Lys Glu Cys Asp Trp Leu Asn Asn Tyr His 
        595                 600                 605             


Leu Thr Cys Arg Asp Val Ile Gly Lys Glu Leu Gln Lys Gln Gly Arg 
    610                 615                 620                 


Gln Glu Ala Leu Glu Trp Leu Ile Arg Glu Thr Gln Pro Ile Ser Lys 
625                 630                 635                 640 


Gln His 
        


<210>  207
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  207

Met Pro Pro Lys Val Thr Ser Glu Leu Leu Arg Gln Leu Arg Gln Ala 
1               5                   10                  15      


Met Arg Asn Ser Glu Tyr Val Thr Glu Pro Ile Gln Ala Tyr Ile Ile 
            20                  25                  30          


Pro Ser Gly Asp Ala His Gln Ser Glu Tyr Ile Ala Pro Cys Asp Cys 
        35                  40                  45              


Arg Arg Ala Phe Val Ser Gly Phe Asp Gly Ser Ala Gly Thr Ala Ile 
    50                  55                  60                  


Ile Thr Glu Glu His Ala Ala Met Trp Thr Asp Gly Arg Tyr Phe Leu 
65                  70                  75                  80  


Gln Ala Ala Lys Gln Met Asp Ser Asn Trp Thr Leu Met Lys Met Gly 
                85                  90                  95      


Leu Lys Asp Thr Pro Thr Gln Glu Asp Trp Leu Val Ser Val Leu Pro 
            100                 105                 110         


Glu Gly Ser Arg Val Gly Val Asp Pro Leu Ile Ile Pro Thr Asp Tyr 
        115                 120                 125             


Trp Lys Lys Met Ala Lys Val Leu Arg Ser Ala Gly His His Leu Ile 
    130                 135                 140                 


Pro Val Lys Glu Asn Leu Val Asp Lys Ile Trp Thr Asp Arg Pro Glu 
145                 150                 155                 160 


Arg Pro Cys Lys Pro Leu Leu Thr Leu Gly Leu Asp Tyr Thr Gly Ile 
                165                 170                 175     


Ser Trp Lys Asp Lys Val Ala Asp Leu Arg Leu Lys Met Ala Glu Arg 
            180                 185                 190         


Asn Val Met Trp Phe Val Val Thr Ala Leu Asp Glu Ile Ala Trp Leu 
        195                 200                 205             


Phe Asn Leu Arg Gly Ser Asp Val Glu His Asn Pro Val Phe Phe Ser 
    210                 215                 220                 


Tyr Ala Ile Ile Gly Leu Glu Thr Ile Met Leu Phe Ile Asp Gly Asp 
225                 230                 235                 240 


Arg Ile Asp Ala Pro Ser Val Lys Glu His Leu Leu Leu Asp Leu Gly 
                245                 250                 255     


Leu Glu Ala Glu Tyr Arg Ile Gln Val His Pro Tyr Lys Ser Ile Leu 
            260                 265                 270         


Ser Glu Leu Lys Ala Leu Cys Ala Asp Leu Ser Pro Arg Glu Lys Val 
        275                 280                 285             


Trp Val Ser Asp Lys Ala Ser Tyr Ala Val Ser Glu Thr Ile Pro 
    290                 295                 300             


<210>  208
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  208

Met Trp Thr Asp Gly Arg Tyr Phe Leu Gln Ala Ala Lys Gln Met Asp 
1               5                   10                  15      


Ser Asn Trp Thr Leu Met Lys Met Gly Leu Lys Asp Thr Pro Thr Gln 
            20                  25                  30          


Glu Asp Trp Leu Val Ser Val Leu Pro Glu Gly Ser Arg Val Gly Val 
        35                  40                  45              


Asp Pro Leu Ile Ile Pro Thr Asp Tyr Trp Lys Lys Met Ala Lys Val 
    50                  55                  60                  


Leu Arg Ser Ala Gly His His Leu Ile Pro Val Lys Glu Asn Leu Val 
65                  70                  75                  80  


Asp Lys Ile Trp Thr Asp Arg Pro Glu Arg Pro Cys Lys Pro Leu Leu 
                85                  90                  95      


Thr Leu Gly Leu Asp Tyr Thr Gly Ile Ser Trp Lys Asp Lys Val Ala 
            100                 105                 110         


Asp Leu Arg Leu Lys Met Ala Glu Arg Asn Val Met Trp Phe Val Val 
        115                 120                 125             


Thr Ala Leu Asp Glu Ile Ala Trp Leu Phe Asn Leu Arg Gly Ser Asp 
    130                 135                 140                 


Val Glu His Asn Pro Val Phe Phe Ser Tyr Ala Ile Ile Gly Leu Glu 
145                 150                 155                 160 


Thr Ile Met Leu Phe Ile Asp Gly Asp Arg Ile Asp Ala Pro Ser Val 
                165                 170                 175     


Lys Glu His Leu Leu Leu Asp Leu Gly Leu Glu Ala Glu Tyr Arg Ile 
            180                 185                 190         


Gln Val His Pro Tyr Lys Ser Ile Leu Ser Glu Leu Lys Ala Leu Cys 
        195                 200                 205             


Ala Asp Leu Ser Pro Arg Glu Lys Val Trp Val Ser Asp Lys Ala Ser 
    210                 215                 220                 


Tyr Ala Val Ser Glu Thr Ile Pro Lys Asp His Arg Cys Cys Met Pro 
225                 230                 235                 240 


Tyr Thr Pro Ile Cys Ile Ala Lys Ala Val Lys Asn Ser Ala Glu Ser 
                245                 250                 255     


Glu Gly Met Arg Arg Ala His Ile Lys Asp Ala Val Ala Leu Cys Glu 
            260                 265                 270         


Leu Phe Asn Trp Leu Glu Lys Glu Val Pro Lys Gly Gly Val Thr Glu 
        275                 280                 285             


Ile Ser Ala Ala Asp Lys Ala Glu Glu Phe Arg Arg Gln Gln Ala Asp 
    290                 295                 300                 


Phe Val Asp Leu Ser Phe Pro Thr Ile Ser Ser Thr Gly Pro Asn Gly 
305                 310                 315                 320 


Ala Ile Ile His Tyr Ala Pro Val Pro Glu Thr Asn Arg Thr Leu Ser 
                325                 330                 335     


Leu Asp Glu Val Tyr Leu Ile Asp Ser Gly Ala Gln Tyr Lys Asp Gly 
            340                 345                 350         


Thr Thr Asp Val Thr Arg Thr Met His Phe Gly Thr Pro Thr Ala Tyr 
        355                 360                 365             


Glu Lys Glu Cys Phe Thr Tyr Val Leu Lys Gly His Ile Ala Val Ser 
    370                 375                 380                 


Ala Ala Val Phe Pro Thr Gly Thr Lys Gly His Leu Leu Asp Ser Phe 
385                 390                 395                 400 


Ala Arg Ser Ala Leu Trp Asp Ser Gly Leu Asp Tyr Leu His Gly Thr 
                405                 410                 415     


Gly His Gly Val Gly Ser Phe Leu Asn Val His Glu Gly Pro Cys Gly 
            420                 425                 430         


Ile Ser Tyr Lys Thr Phe Ser Asp Glu Pro Leu Glu Ala Gly Met Ile 
        435                 440                 445             


Val Thr Asp Glu Pro Gly Tyr Tyr Glu Asp Gly Ala Phe Gly Ile Arg 
    450                 455                 460                 


Ile Glu Asn Val Val Leu Val Val Pro Val Lys Thr Lys Tyr Asn Phe 
465                 470                 475                 480 


Asn Asn Arg Gly Ser Leu Thr Phe Glu Pro Leu Thr Leu Val Pro Ile 
                485                 490                 495     


Gln Thr Lys Met Ile Asp Val Asp Ser Leu Thr Asp Lys Glu Cys Asp 
            500                 505                 510         


Trp Leu Asn Asn Tyr His Leu Thr Cys Arg Asp Val Ile Gly Lys Glu 
        515                 520                 525             


Leu Gln Lys Gln Gly Arg Gln Glu Ala Leu Glu Trp Leu Ile Arg Glu 
    530                 535                 540                 


Thr Gln Pro Ile Ser Lys Gln His 
545                 550         


<210>  209
<211>  666
<212>  PRT
<213>  Homo sapiens

<400>  209

Met Ala Ala Ser Arg Lys Pro Pro Arg Val Arg Val Asn His Gln Asp 
1               5                   10                  15      


Phe Gln Leu Arg Asn Leu Arg Ile Ile Glu Pro Asn Glu Val Thr His 
            20                  25                  30          


Ser Gly Asp Thr Gly Val Glu Thr Asp Gly Arg Met Pro Pro Lys Val 
        35                  40                  45              


Thr Ser Glu Leu Leu Arg Gln Leu Arg Gln Ala Met Arg Asn Ser Glu 
    50                  55                  60                  


Tyr Val Thr Glu Pro Ile Gln Ala Tyr Ile Ile Pro Ser Gly Asp Ala 
65                  70                  75                  80  


His Gln Ser Glu Tyr Ile Ala Pro Cys Asp Cys Arg Arg Ala Phe Val 
                85                  90                  95      


Ser Gly Phe Asp Gly Ser Ala Gly Thr Ala Ile Ile Thr Glu Glu His 
            100                 105                 110         


Ala Ala Met Trp Thr Asp Gly Arg Tyr Phe Leu Gln Ala Ala Lys Gln 
        115                 120                 125             


Met Asp Ser Asn Trp Thr Leu Met Lys Met Gly Leu Lys Asp Thr Pro 
    130                 135                 140                 


Thr Gln Glu Asp Trp Leu Val Ser Val Leu Pro Glu Gly Ser Arg Val 
145                 150                 155                 160 


Gly Val Asp Pro Leu Ile Ile Pro Thr Asp Tyr Trp Lys Lys Met Ala 
                165                 170                 175     


Lys Val Leu Arg Ser Ala Gly His His Leu Ile Pro Val Lys Glu Asn 
            180                 185                 190         


Leu Val Asp Lys Ile Trp Thr Asp Arg Pro Glu Arg Pro Cys Lys Pro 
        195                 200                 205             


Leu Leu Thr Leu Gly Leu Asp Tyr Thr Gly Ile Ser Trp Lys Asp Lys 
    210                 215                 220                 


Val Ala Asp Leu Arg Leu Lys Met Ala Glu Arg Asn Val Met Trp Phe 
225                 230                 235                 240 


Val Val Thr Ala Leu Asp Glu Ile Ala Trp Leu Phe Asn Leu Arg Gly 
                245                 250                 255     


Ser Asp Val Glu His Asn Pro Val Phe Phe Ser Tyr Ala Ile Ile Gly 
            260                 265                 270         


Leu Glu Thr Ile Met Leu Phe Ile Asp Gly Asp Arg Ile Asp Ala Pro 
        275                 280                 285             


Ser Val Lys Glu His Leu Leu Leu Asp Leu Gly Leu Glu Ala Glu Tyr 
    290                 295                 300                 


Arg Ile Gln Val His Pro Tyr Lys Ser Ile Leu Ser Glu Leu Lys Ala 
305                 310                 315                 320 


Leu Cys Ala Asp Leu Ser Pro Arg Glu Lys Val Trp Val Ser Asp Lys 
                325                 330                 335     


Ala Ser Tyr Ala Val Ser Glu Thr Ile Pro Lys Asp His Arg Cys Cys 
            340                 345                 350         


Met Pro Tyr Thr Pro Ile Cys Ile Ala Lys Ala Val Lys Asn Ser Ala 
        355                 360                 365             


Glu Ser Glu Gly Met Arg Arg Ala His Ile Lys Asp Ala Val Ala Leu 
    370                 375                 380                 


Cys Glu Leu Phe Asn Trp Leu Glu Lys Glu Val Pro Lys Gly Gly Val 
385                 390                 395                 400 


Thr Glu Ile Ser Ala Ala Asp Lys Ala Glu Glu Phe Arg Arg Gln Gln 
                405                 410                 415     


Ala Asp Phe Val Asp Leu Ser Phe Pro Thr Ile Ser Ser Thr Gly Pro 
            420                 425                 430         


Asn Gly Ala Ile Ile His Tyr Ala Pro Val Pro Glu Thr Asn Arg Thr 
        435                 440                 445             


Leu Ser Leu Asp Glu Val Tyr Leu Ile Asp Ser Gly Ala Gln Tyr Lys 
    450                 455                 460                 


Asp Gly Thr Thr Asp Val Thr Arg Thr Met His Phe Gly Thr Pro Thr 
465                 470                 475                 480 


Ala Tyr Glu Lys Glu Cys Phe Thr Tyr Val Leu Lys Gly His Ile Ala 
                485                 490                 495     


Val Ser Ala Ala Val Phe Pro Thr Gly Thr Lys Gly His Leu Leu Asp 
            500                 505                 510         


Ser Phe Ala Arg Ser Ala Leu Trp Asp Ser Gly Leu Asp Tyr Leu His 
        515                 520                 525             


Gly Thr Gly His Gly Val Gly Ser Phe Leu Asn Val His Glu Gly Pro 
    530                 535                 540                 


Cys Gly Ile Ser Tyr Lys Thr Phe Ser Asp Glu Pro Leu Glu Ala Gly 
545                 550                 555                 560 


Met Ile Val Thr Asp Glu Pro Gly Tyr Tyr Glu Asp Gly Ala Phe Gly 
                565                 570                 575     


Ile Arg Ile Glu Asn Val Val Leu Val Val Pro Val Lys Thr Lys Tyr 
            580                 585                 590         


Asn Phe Asn Asn Arg Gly Ser Leu Thr Phe Glu Pro Leu Thr Leu Val 
        595                 600                 605             


Pro Ile Gln Thr Lys Met Ile Asp Val Asp Ser Leu Thr Asp Lys Glu 
    610                 615                 620                 


Cys Asp Trp Leu Asn Asn Tyr His Leu Thr Cys Arg Asp Val Ile Gly 
625                 630                 635                 640 


Lys Glu Leu Gln Lys Gln Gly Arg Gln Glu Ala Leu Glu Trp Leu Ile 
                645                 650                 655     


Arg Glu Thr Gln Pro Ile Ser Lys Gln His 
            660                 665     


<210>  210
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  210

Met Pro Pro Lys Val Thr Ser Glu Leu Leu Arg Gln Leu Arg Gln Ala 
1               5                   10                  15      


Met Arg Asn Ser Glu Tyr Val Thr Glu Pro Ile Gln Ala Tyr Ile Ile 
            20                  25                  30          


Pro Ser Gly Asp Ala His Gln Ser Glu Tyr Ile Ala Pro Cys Asp Cys 
        35                  40                  45              


Arg Arg Ala Phe Val Ser Gly Phe Asp Gly Ser Ala Gly Thr Ala Ile 
    50                  55                  60                  


Ile Thr Glu Glu His Ala Ala Met Trp Thr Asp Gly Arg Tyr Phe Leu 
65                  70                  75                  80  


Gln Ala Ala Lys Gln Met Asp Ser Asn Trp Thr Leu Met Lys Met Gly 
                85                  90                  95      


Leu Lys Asp Thr Pro Thr Gln Glu Asp Trp Leu Val Ser Val Leu Pro 
            100                 105                 110         


Glu Gly Ser Arg Val Gly Val Asp Pro Leu Ile Ile Pro Thr Asp Tyr 
        115                 120                 125             


Trp Lys Lys Met Ala Lys Val Leu Arg Ser Ala Gly His His Leu Ile 
    130                 135                 140                 


Pro Val Lys Glu Asn Leu Val Asp Lys Ile Trp Thr Asp Arg Pro Glu 
145                 150                 155                 160 


Arg Pro Cys Lys Pro Leu Leu Thr Leu Gly Leu Asp Tyr Thr Gly Leu 
                165                 170                 175     


Phe Asn Leu Arg Gly Ser Asp Val Glu His Asn Pro Val Phe Phe Ser 
            180                 185                 190         


Tyr Ala Ile Ile Gly Leu Glu Thr Ile Met Leu Phe Ile Asp Gly Asp 
        195                 200                 205             


Arg Ile Asp Ala Pro Ser Val Lys Glu His Leu Leu Leu Asp Leu Gly 
    210                 215                 220                 


Leu Glu Ala Glu Tyr Arg Ile Gln Val 
225                 230             


<210>  211
<211>  737
<212>  PRT
<213>  Homo sapiens

<400>  211

Met Val Val Phe Asn Gly Leu Leu Lys Ile Lys Ile Cys Glu Ala Val 
1               5                   10                  15      


Ser Leu Lys Pro Thr Ala Trp Ser Leu Arg His Ala Val Gly Pro Arg 
            20                  25                  30          


Pro Gln Thr Phe Leu Leu Asp Pro Tyr Ile Ala Leu Asn Val Asp Asp 
        35                  40                  45              


Ser Arg Ile Gly Gln Thr Ala Thr Lys Gln Lys Thr Asn Ser Pro Ala 
    50                  55                  60                  


Trp His Asp Glu Phe Val Thr Asp Val Cys Asn Gly Arg Lys Ile Glu 
65                  70                  75                  80  


Leu Ala Val Phe His Asp Ala Pro Ile Gly Tyr Asp Asp Phe Val Ala 
                85                  90                  95      


Asn Cys Thr Ile Gln Phe Glu Glu Leu Leu Gln Asn Gly Ser Arg His 
            100                 105                 110         


Phe Glu Asp Trp Ile Asp Leu Glu Pro Glu Gly Arg Val Tyr Val Ile 
        115                 120                 125             


Ile Asp Leu Ser Gly Ser Ser Gly Glu Ala Pro Lys Asp Asn Glu Glu 
    130                 135                 140                 


Arg Val Phe Arg Glu Arg Met Arg Pro Arg Lys Arg Gln Gly Ala Val 
145                 150                 155                 160 


Arg Arg Arg Val His Gln Val Asn Gly His Lys Phe Met Ala Thr Tyr 
                165                 170                 175     


Leu Arg Gln Pro Thr Tyr Cys Ser His Cys Arg Asp Phe Ile Trp Gly 
            180                 185                 190         


Val Ile Gly Lys Gln Gly Tyr Gln Cys Gln Val Cys Thr Cys Val Val 
        195                 200                 205             


His Lys Arg Cys His Glu Leu Ile Ile Thr Lys Cys Ala Gly Leu Lys 
    210                 215                 220                 


Lys Gln Glu Thr Pro Asp Gln Val Gly Ser Gln Arg Phe Ser Val Asn 
225                 230                 235                 240 


Met Pro His Lys Phe Gly Ile His Asn Tyr Lys Val Pro Thr Phe Cys 
                245                 250                 255     


Asp His Cys Gly Ser Leu Leu Trp Gly Leu Leu Arg Gln Gly Leu Gln 
            260                 265                 270         


Cys Lys Val Cys Lys Met Asn Val His Arg Arg Cys Glu Thr Asn Val 
        275                 280                 285             


Ala Pro Asn Cys Gly Val Asp Ala Arg Gly Ile Ala Lys Val Leu Ala 
    290                 295                 300                 


Asp Leu Gly Val Thr Pro Asp Lys Ile Thr Asn Ser Gly Gln Arg Arg 
305                 310                 315                 320 


Lys Lys Leu Ile Ala Gly Ala Glu Ser Pro Gln Pro Ala Ser Gly Ser 
                325                 330                 335     


Ser Pro Ser Glu Glu Asp Arg Ser Lys Ser Ala Pro Thr Ser Pro Cys 
            340                 345                 350         


Asp Gln Glu Ile Lys Glu Leu Glu Asn Asn Ile Arg Lys Ala Leu Ser 
        355                 360                 365             


Phe Asp Asn Arg Gly Glu Glu His Arg Ala Ala Ser Ser Pro Asp Gly 
    370                 375                 380                 


Gln Leu Met Ser Pro Gly Glu Asn Gly Glu Val Arg Gln Gly Gln Ala 
385                 390                 395                 400 


Lys Arg Leu Gly Leu Asp Glu Phe Asn Phe Ile Lys Val Leu Gly Lys 
                405                 410                 415     


Gly Ser Phe Gly Lys Val Met Leu Ala Glu Leu Lys Gly Lys Asp Glu 
            420                 425                 430         


Val Tyr Ala Val Lys Val Leu Lys Lys Asp Val Ile Leu Gln Asp Asp 
        435                 440                 445             


Asp Val Asp Cys Thr Met Thr Glu Lys Arg Ile Leu Ala Leu Ala Arg 
    450                 455                 460                 


Lys His Pro Tyr Leu Thr Gln Leu Tyr Cys Cys Phe Gln Thr Lys Asp 
465                 470                 475                 480 


Arg Leu Phe Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Phe 
                485                 490                 495     


Gln Ile Gln Arg Ser Arg Lys Phe Asp Glu Pro Arg Ser Arg Phe Tyr 
            500                 505                 510         


Ala Ala Glu Val Thr Ser Ala Leu Met Phe Leu His Gln His Gly Val 
        515                 520                 525             


Ile Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu Asp Ala Glu Gly 
    530                 535                 540                 


His Cys Lys Leu Ala Asp Phe Gly Met Cys Lys Glu Gly Ile Leu Asn 
545                 550                 555                 560 


Gly Val Thr Thr Thr Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro 
                565                 570                 575     


Glu Ile Leu Gln Glu Leu Glu Tyr Gly Pro Ser Val Asp Trp Trp Ala 
            580                 585                 590         


Leu Gly Val Leu Met Tyr Glu Met Met Ala Gly Gln Pro Pro Phe Glu 
        595                 600                 605             


Ala Asp Asn Glu Asp Asp Leu Phe Glu Ser Ile Leu His Asp Asp Val 
    610                 615                 620                 


Leu Tyr Pro Val Trp Leu Ser Lys Glu Ala Val Ser Ile Leu Lys Ala 
625                 630                 635                 640 


Phe Met Thr Lys Asn Pro His Lys Arg Leu Gly Cys Val Ala Ser Gln 
                645                 650                 655     


Asn Gly Glu Asp Ala Ile Lys Gln His Pro Phe Phe Lys Glu Ile Asp 
            660                 665                 670         


Trp Val Leu Leu Glu Gln Lys Lys Ile Lys Pro Pro Phe Lys Pro Arg 
        675                 680                 685             


Ile Lys Thr Lys Arg Asp Val Asn Asn Phe Asp Gln Asp Phe Thr Arg 
    690                 695                 700                 


Glu Glu Pro Val Leu Thr Leu Val Asp Glu Ala Ile Val Lys Gln Ile 
705                 710                 715                 720 


Asn Gln Glu Glu Phe Lys Gly Phe Ser Tyr Phe Gly Glu Asp Leu Met 
                725                 730                 735     


Pro 
    


<210>  212
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  212

Met Asn Val His Arg Arg Cys Glu Thr Asn Val Ala Pro Asn Cys Gly 
1               5                   10                  15      


Val Asp Ala Arg Gly Ile Ala Lys Val Leu Ala Asp Leu Gly Val Thr 
            20                  25                  30          


Pro Asp Lys Ile Thr Asn Ser Gly Gln Arg Arg Lys Lys Leu Ile Ala 
        35                  40                  45              


Gly Ala Glu Ser Pro Gln Pro Ala Ser Gly Ser Ser Pro Ser Glu Glu 
    50                  55                  60                  


Asp Arg Ser Lys Ser Ala Pro Thr Ser Pro Cys Asp Gln Glu Ile Lys 
65                  70                  75                  80  


Glu Leu Glu Asn Asn Ile Arg Lys Ala Leu Ser Phe Asp Asn Arg Gly 
                85                  90                  95      


Glu Glu His Arg Ala Ala Ser Ser Pro Asp Gly Gln Leu Met Ser Pro 
            100                 105                 110         


Gly Glu Asn Gly Glu Val Arg Gln Gly Gln Ala Lys Arg Leu Gly Leu 
        115                 120                 125             


Asp Glu Phe Asn Phe Ile Lys Val Leu Gly Lys Gly Ser Phe Gly Lys 
    130                 135                 140                 


Val Met Leu Ala Glu Leu Lys Gly Lys Asp Glu Val Tyr Ala Val Lys 
145                 150                 155                 160 


Val Leu Lys Lys Asp Val Ile Leu Gln Asp Asp Asp Val Asp Cys Thr 
                165                 170                 175     


Met Thr Glu Lys Arg Ile Leu Ala Leu Ala Arg Lys His Pro Tyr Leu 
            180                 185                 190         


Thr Gln Leu Tyr Cys Cys Phe Gln Thr Lys Gly Thr Gly Phe Ser Ile 
        195                 200                 205             


Gln Gly Cys Ala Cys Glu Gly Met Arg Glu Leu 
    210                 215                 


<210>  213
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  213

Met Val Val Phe Asn Gly Leu Leu Lys Ile Lys Ile Cys Glu Ala Val 
1               5                   10                  15      


Ser Leu Lys Pro Thr Ala Trp Ser Leu Arg His Ala Val Gly Pro Arg 
            20                  25                  30          


Pro Gln Thr Phe Leu Leu Asp Pro Tyr Ile Ala Leu Asn Val Asp Asp 
        35                  40                  45              


Ser Arg Ile Gly Gln Thr Ala Thr Lys Gln Lys Thr Asn Ser Pro Ala 
    50                  55                  60                  


Trp His Asp Glu Phe Val Thr Asp Val Cys Asn Gly Arg Lys Ile Glu 
65                  70                  75                  80  


Leu Ala Val Phe His Asp Ala Pro Ile Gly Tyr Asp Asp Phe Val Ala 
                85                  90                  95      


Asn Cys Thr Ile Gln Phe Glu Glu Leu Leu Gln Asn Gly Ser Arg His 
            100                 105                 110         


Phe Glu Asp Trp Ile Asp Leu Glu Pro Glu Gly Arg Val Tyr Val 
        115                 120                 125         


<210>  214
<211>  851
<212>  PRT
<213>  Homo sapiens

<400>  214

Met Ala Gln Trp Glu Met Leu Gln Asn Leu Asp Ser Pro Phe Gln Asp 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser His Ser Leu Leu Pro Val Asp Ile Arg 
            20                  25                  30          


Gln Tyr Leu Ala Val Trp Ile Glu Asp Gln Asn Trp Gln Glu Ala Ala 
        35                  40                  45              


Leu Gly Ser Asp Asp Ser Lys Ala Thr Met Leu Phe Phe His Phe Leu 
    50                  55                  60                  


Asp Gln Leu Asn Tyr Glu Cys Gly Arg Cys Ser Gln Asp Pro Glu Ser 
65                  70                  75                  80  


Leu Leu Leu Gln His Asn Leu Arg Lys Phe Cys Arg Asp Ile Gln Pro 
                85                  90                  95      


Phe Ser Gln Asp Pro Thr Gln Leu Ala Glu Met Ile Phe Asn Leu Leu 
            100                 105                 110         


Leu Glu Glu Lys Arg Ile Leu Ile Gln Ala Gln Arg Ala Gln Leu Glu 
        115                 120                 125             


Gln Gly Glu Pro Val Leu Glu Thr Pro Val Glu Ser Gln Gln His Glu 
    130                 135                 140                 


Ile Glu Ser Arg Ile Leu Asp Leu Arg Ala Met Met Glu Lys Leu Val 
145                 150                 155                 160 


Lys Ser Ile Ser Gln Leu Lys Asp Gln Gln Asp Val Phe Cys Phe Arg 
                165                 170                 175     


Tyr Lys Ile Gln Ala Lys Gly Lys Thr Pro Ser Leu Asp Pro His Gln 
            180                 185                 190         


Thr Lys Glu Gln Lys Ile Leu Gln Glu Thr Leu Asn Glu Leu Asp Lys 
        195                 200                 205             


Arg Arg Lys Glu Val Leu Asp Ala Ser Lys Ala Leu Leu Gly Arg Leu 
    210                 215                 220                 


Thr Thr Leu Ile Glu Leu Leu Leu Pro Lys Leu Glu Glu Trp Lys Ala 
225                 230                 235                 240 


Gln Gln Gln Lys Ala Cys Ile Arg Ala Pro Ile Asp His Gly Leu Glu 
                245                 250                 255     


Gln Leu Glu Thr Trp Phe Thr Ala Gly Ala Lys Leu Leu Phe His Leu 
            260                 265                 270         


Arg Gln Leu Leu Lys Glu Leu Lys Gly Leu Ser Cys Leu Val Ser Tyr 
        275                 280                 285             


Gln Asp Asp Pro Leu Thr Lys Gly Val Asp Leu Arg Asn Ala Gln Val 
    290                 295                 300                 


Thr Glu Leu Leu Gln Arg Leu Leu His Arg Ala Phe Val Val Glu Thr 
305                 310                 315                 320 


Gln Pro Cys Met Pro Gln Thr Pro His Arg Pro Leu Ile Leu Lys Thr 
                325                 330                 335     


Gly Ser Lys Phe Thr Val Arg Thr Arg Leu Leu Val Arg Leu Gln Glu 
            340                 345                 350         


Gly Asn Glu Ser Leu Thr Val Glu Val Ser Ile Asp Arg Asn Pro Pro 
        355                 360                 365             


Gln Leu Gln Gly Phe Arg Lys Phe Asn Ile Leu Thr Ser Asn Gln Lys 
    370                 375                 380                 


Thr Leu Thr Pro Glu Lys Gly Gln Ser Gln Gly Leu Ile Trp Asp Phe 
385                 390                 395                 400 


Gly Tyr Leu Thr Leu Val Glu Gln Arg Ser Gly Gly Ser Gly Lys Gly 
                405                 410                 415     


Ser Asn Lys Gly Pro Leu Gly Val Thr Glu Glu Leu His Ile Ile Ser 
            420                 425                 430         


Phe Thr Val Lys Tyr Thr Tyr Gln Gly Leu Lys Gln Glu Leu Lys Thr 
        435                 440                 445             


Asp Thr Leu Pro Val Val Ile Ile Ser Asn Met Asn Gln Leu Ser Ile 
    450                 455                 460                 


Ala Trp Ala Ser Val Leu Trp Phe Asn Leu Leu Ser Pro Asn Leu Gln 
465                 470                 475                 480 


Asn Gln Gln Phe Phe Ser Asn Pro Pro Lys Ala Pro Trp Ser Leu Leu 
                485                 490                 495     


Gly Pro Ala Leu Ser Trp Gln Phe Ser Ser Tyr Val Gly Arg Gly Leu 
            500                 505                 510         


Asn Ser Asp Gln Leu Ser Met Leu Arg Asn Lys Leu Phe Gly Gln Asn 
        515                 520                 525             


Cys Arg Thr Glu Asp Pro Leu Leu Ser Trp Ala Asp Phe Thr Lys Arg 
    530                 535                 540                 


Glu Ser Pro Pro Gly Lys Leu Pro Phe Trp Thr Trp Leu Asp Lys Ile 
545                 550                 555                 560 


Leu Glu Leu Val His Asp His Leu Lys Asp Leu Trp Asn Asp Gly Arg 
                565                 570                 575     


Ile Met Gly Phe Val Ser Arg Ser Gln Glu Arg Arg Leu Leu Lys Lys 
            580                 585                 590         


Thr Met Ser Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Glu Gly 
        595                 600                 605             


Gly Ile Thr Cys Ser Trp Val Glu His Gln Asp Asp Asp Lys Val Leu 
    610                 615                 620                 


Ile Tyr Ser Val Gln Pro Tyr Thr Lys Glu Val Leu Gln Ser Leu Pro 
625                 630                 635                 640 


Leu Thr Glu Ile Ile Arg His Tyr Gln Leu Leu Thr Glu Glu Asn Ile 
                645                 650                 655     


Pro Glu Asn Pro Leu Arg Phe Leu Tyr Pro Arg Ile Pro Arg Asp Glu 
            660                 665                 670         


Ala Phe Gly Cys Tyr Tyr Gln Glu Lys Val Asn Leu Gln Glu Arg Arg 
        675                 680                 685             


Lys Tyr Leu Lys His Arg Leu Ile Val Val Ser Asn Arg Gln Val Asp 
    690                 695                 700                 


Glu Leu Gln Gln Pro Leu Glu Leu Lys Pro Glu Pro Glu Leu Glu Ser 
705                 710                 715                 720 


Leu Glu Leu Glu Leu Gly Leu Val Pro Glu Pro Glu Leu Ser Leu Asp 
                725                 730                 735     


Leu Glu Pro Leu Leu Lys Ala Gly Leu Asp Leu Gly Pro Glu Leu Glu 
            740                 745                 750         


Ser Val Leu Glu Ser Thr Leu Glu Pro Val Ile Glu Pro Thr Leu Cys 
        755                 760                 765             


Met Val Ser Gln Thr Val Pro Glu Pro Asp Gln Gly Pro Val Ser Gln 
    770                 775                 780                 


Pro Val Pro Glu Pro Asp Leu Pro Cys Asp Leu Arg His Leu Asn Thr 
785                 790                 795                 800 


Glu Pro Met Glu Ile Phe Arg Asn Cys Val Lys Ile Glu Glu Ile Met 
                805                 810                 815     


Pro Asn Gly Asp Pro Leu Leu Ala Gly Gln Asn Thr Val Asp Glu Val 
            820                 825                 830         


Tyr Val Ser Arg Pro Ser His Phe Tyr Thr Asp Gly Pro Leu Met Pro 
        835                 840                 845             


Ser Asp Phe 
    850     


<210>  215
<211>  460
<212>  PRT
<213>  Homo sapiens

<400>  215

Met Ala Gln Trp Glu Met Leu Gln Asn Leu Asp Ser Pro Phe Gln Asp 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser His Ser Leu Leu Pro Val Asp Ile Arg 
            20                  25                  30          


Gln Tyr Leu Ala Val Trp Ile Glu Asp Gln Asn Trp Gln Glu Ala Ala 
        35                  40                  45              


Leu Gly Ser Asp Asp Ser Lys Ala Thr Met Leu Phe Phe His Phe Leu 
    50                  55                  60                  


Asp Gln Leu Asn Tyr Glu Cys Gly Arg Cys Ser Gln Asp Pro Glu Ser 
65                  70                  75                  80  


Leu Leu Leu Gln His Asn Leu Arg Lys Phe Cys Arg Asp Ile Gln Asp 
                85                  90                  95      


Pro Thr Gln Leu Ala Glu Met Ile Phe Asn Leu Leu Leu Glu Glu Lys 
            100                 105                 110         


Arg Ile Leu Ile Gln Ala Gln Arg Ala Gln Leu Glu Gln Gly Glu Pro 
        115                 120                 125             


Val Leu Glu Thr Pro Val Glu Ser Gln Gln His Glu Ile Glu Ser Arg 
    130                 135                 140                 


Ile Leu Asp Leu Arg Ala Met Met Glu Lys Leu Val Lys Ser Ile Ser 
145                 150                 155                 160 


Gln Leu Lys Asp Gln Gln Asp Val Phe Cys Phe Arg Tyr Lys Ile Gln 
                165                 170                 175     


Ala Lys Gly Lys Thr Pro Ser Leu Asp Pro His Gln Thr Lys Glu Gln 
            180                 185                 190         


Lys Ile Leu Gln Glu Thr Leu Asn Glu Leu Asp Lys Arg Arg Lys Glu 
        195                 200                 205             


Val Leu Asp Ala Ser Lys Ala Leu Leu Gly Arg Leu Thr Thr Leu Ile 
    210                 215                 220                 


Glu Leu Leu Leu Pro Lys Leu Glu Glu Trp Lys Ala Gln Gln Gln Lys 
225                 230                 235                 240 


Ala Cys Ile Arg Ala Pro Ile Asp His Gly Leu Glu Gln Leu Glu Thr 
                245                 250                 255     


Trp Phe Thr Ala Gly Ala Lys Leu Leu Phe His Leu Arg Gln Leu Leu 
            260                 265                 270         


Lys Glu Leu Lys Gly Leu Ser Cys Leu Val Ser Tyr Gln Asp Asp Pro 
        275                 280                 285             


Leu Thr Lys Gly Val Asp Leu Arg Asn Ala Gln Val Thr Glu Leu Leu 
    290                 295                 300                 


Gln Arg Leu Leu His Arg Ala Phe Val Val Glu Thr Gln Pro Cys Met 
305                 310                 315                 320 


Pro Gln Thr Pro His Arg Pro Leu Ile Leu Lys Thr Gly Ser Lys Phe 
                325                 330                 335     


Thr Val Arg Thr Arg Leu Leu Val Arg Leu Gln Glu Gly Asn Glu Ser 
            340                 345                 350         


Leu Thr Val Glu Val Ser Ile Asp Arg Asn Pro Pro Gln Leu Gln Gly 
        355                 360                 365             


Phe Arg Lys Phe Asn Ile Leu Thr Ser Asn Gln Lys Thr Leu Thr Pro 
    370                 375                 380                 


Glu Lys Gly Gln Ser Gln Gly Leu Ile Trp Asp Phe Gly Tyr Leu Thr 
385                 390                 395                 400 


Leu Val Glu Gln Arg Ser Gly Gly Ser Gly Lys Gly Ser Asn Lys Gly 
                405                 410                 415     


Pro Leu Gly Val Thr Glu Glu Leu His Ile Ile Ser Phe Thr Val Lys 
            420                 425                 430         


Tyr Thr Tyr Gln Gly Leu Lys Gln Glu Leu Lys Val Ser Glu Asn Gly 
        435                 440                 445             


Gly Gln Gly Glu Arg Lys Gln Leu Trp Lys Lys Ala 
    450                 455                 460 


<210>  216
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  216

Met Ala Gln Trp Glu Met Leu Gln Asn Leu Asp Ser Pro Phe Gln Asp 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser His Ser Leu Leu Pro Val Asp Ile Arg 
            20                  25                  30          


Gln Tyr Leu Ala Val Trp Ile Glu Asp Gln Asn Trp Gln Glu Ala Ala 
        35                  40                  45              


Leu Gly Ser Asp Asp Ser Lys Ala Thr Met Leu Phe Phe His Phe Leu 
    50                  55                  60                  


Asp Gln Leu Asn Tyr Glu Cys Gly Arg Cys Ser Gln Asp Pro Glu Ser 
65                  70                  75                  80  


Leu Leu Leu Gln His Asn Leu Arg Lys Phe Cys Arg Asp Ile Gln Pro 
                85                  90                  95      


Phe Ser Gln Asp Pro Thr Gln Leu Ala Glu Met Ile Phe Asn Leu Leu 
            100                 105                 110         


Leu Glu Glu Lys Arg Ile Leu Ile Gln Ala Gln Arg Ala Gln Leu Glu 
        115                 120                 125             


Gln Gly Glu Pro Val Leu Glu Thr Pro Val Glu Ser Gln Gln His Glu 
    130                 135                 140                 


Ile Glu Ser Arg Ile Leu Asp Leu Arg Ala Met Met Glu Lys Leu Val 
145                 150                 155                 160 


Lys Ser Ile Ser Gln Leu Lys Asp Gln Gln Asp Val Phe Cys Phe Arg 
                165                 170                 175     


Tyr Lys Ile Gln Ala Lys Gly Arg Lys His Ile Glu Gly Leu Glu Lys 
            180                 185                 190         


Asp Lys Cys Leu Leu Arg Ser Arg Ser Trp Lys 
        195                 200             


<210>  217
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  217

Met Ala Gln Trp Glu Met Leu Gln Asn Leu Asp Ser Pro Phe Gln Asp 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser His Ser Leu Leu Pro Val Asp Ile Arg 
            20                  25                  30          


Gln Tyr Leu Ala Val Trp Ile Glu Asp Gln Asn Trp Gln Glu Ala Ala 
        35                  40                  45              


Leu Gly Ser Asp Asp Ser Lys Ala Thr Met Leu Phe Phe His Phe Leu 
    50                  55                  60                  


Asp Gln Leu Asn Tyr Glu Cys Gly Arg Cys Ser Gln Asp Pro Glu Ser 
65                  70                  75                  80  


Leu Leu Leu Gln His Asn Leu Arg Lys Phe Cys Arg Asp Ile Gln Asp 
                85                  90                  95      


Pro Thr Gln Leu Ala Glu Met Ile Phe Asn Leu Leu Leu Glu Glu Lys 
            100                 105                 110         


Arg Ile Leu Ile Gln Ala Gln Arg Ala Gln Leu Glu Gln Gly Glu Pro 
        115                 120                 125             


Val Leu Glu Thr Pro Val Glu Ser Gln Gln His Glu Ile Glu Ser Arg 
    130                 135                 140                 


Ile Leu Asp Leu Arg Ala Met Met Glu Lys Leu Val Lys Ser Ile Ser 
145                 150                 155                 160 


Gln Leu Lys Asp Gln Gln Asp Val Phe Cys Phe Arg Tyr Lys Ile Gln 
                165                 170                 175     


Ala Lys Gly Arg Lys His Ile Glu Gly Leu Glu Lys Asp Lys Cys Leu 
            180                 185                 190         


Leu Arg Ser Arg Ser Trp Lys 
        195                 


<210>  218
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  218

Met Ala Gln Trp Glu Met Leu Gln Asn Leu Asp Ser Pro Phe Gln Asp 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser His Ser Leu Leu Pro Val Asp Ile Arg 
            20                  25                  30          


Gln Tyr Leu Ala Val Trp Ile Glu Asp Gln Asn Trp Lys Leu His Leu 
        35                  40                  45              


Gly Val Met Ile Pro Arg Leu Pro Cys Tyr Ser Ser Thr Ser Trp Ile 
    50                  55                  60                  


Ser 
65  


<210>  219
<211>  818
<212>  PRT
<213>  Homo sapiens

<400>  219

Met Ala Gln Trp Glu Met Leu Gln Asn Leu Asp Ser Pro Phe Gln Asp 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser His Ser Leu Leu Pro Val Asp Ile Arg 
            20                  25                  30          


Gln Tyr Leu Ala Val Trp Ile Glu Asp Gln Asn Trp Gln Glu Ala Ala 
        35                  40                  45              


Leu Gly Ser Asp Asp Ser Lys Ala Thr Met Leu Phe Phe His Phe Leu 
    50                  55                  60                  


Asp Gln Leu Asn Tyr Glu Cys Gly Arg Cys Ser Gln Asp Pro Glu Ser 
65                  70                  75                  80  


Leu Leu Leu Gln His Asn Leu Arg Lys Phe Cys Arg Asp Ile Gln Pro 
                85                  90                  95      


Phe Ser Gln Asp Pro Thr Gln Leu Ala Glu Met Ile Phe Asn Leu Leu 
            100                 105                 110         


Leu Glu Glu Lys Arg Ile Leu Ile Gln Ala Gln Arg Ala Gln Leu Glu 
        115                 120                 125             


Gln Gly Glu Pro Val Leu Glu Thr Pro Val Glu Ser Gln Gln His Glu 
    130                 135                 140                 


Ile Glu Ser Arg Ile Leu Asp Leu Arg Ala Met Met Glu Lys Leu Val 
145                 150                 155                 160 


Lys Ser Ile Ser Gln Leu Lys Asp Gln Gln Asp Val Phe Cys Phe Arg 
                165                 170                 175     


Tyr Lys Ile Gln Ala Lys Gly Lys Thr Pro Ser Leu Asp Pro His Gln 
            180                 185                 190         


Thr Lys Glu Gln Lys Ile Leu Gln Glu Thr Leu Asn Glu Leu Asp Lys 
        195                 200                 205             


Arg Arg Lys Glu Val Leu Asp Ala Ser Lys Ala Leu Leu Gly Arg Leu 
    210                 215                 220                 


Thr Thr Leu Ile Glu Leu Leu Leu Pro Lys Leu Glu Glu Trp Lys Ala 
225                 230                 235                 240 


Gln Gln Gln Lys Ala Cys Ile Arg Ala Pro Ile Asp His Gly Leu Glu 
                245                 250                 255     


Gln Leu Glu Thr Trp Phe Thr Ala Gly Ala Lys Leu Leu Phe His Leu 
            260                 265                 270         


Arg Gln Leu Leu Lys Glu Leu Lys Gly Leu Ser Cys Leu Val Ser Tyr 
        275                 280                 285             


Gln Asp Asp Pro Leu Thr Lys Gly Val Asp Leu Arg Asn Ala Gln Val 
    290                 295                 300                 


Thr Glu Leu Leu Gln Arg Leu Leu His Arg Ala Phe Val Val Glu Thr 
305                 310                 315                 320 


Gln Pro Cys Met Pro Gln Thr Pro His Arg Pro Leu Ile Leu Lys Thr 
                325                 330                 335     


Gly Ser Lys Phe Thr Val Arg Thr Arg Leu Leu Val Arg Leu Gln Glu 
            340                 345                 350         


Gly Asn Glu Ser Leu Thr Val Glu Val Ser Ile Asp Arg Asn Pro Pro 
        355                 360                 365             


Gln Leu Gln Gly Phe Arg Lys Phe Asn Ile Leu Thr Ser Asn Gln Lys 
    370                 375                 380                 


Thr Leu Thr Pro Glu Lys Gly Gln Ser Gln Gly Leu Ile Trp Asp Phe 
385                 390                 395                 400 


Gly Tyr Leu Thr Leu Val Glu Gln Arg Ser Gly Gly Ser Gly Lys Gly 
                405                 410                 415     


Ser Asn Lys Gly Pro Leu Gly Val Thr Glu Glu Leu His Ile Ile Ser 
            420                 425                 430         


Phe Thr Val Lys Tyr Thr Tyr Gln Gly Leu Lys Gln Glu Leu Lys Asn 
        435                 440                 445             


Gln Gln Phe Phe Ser Asn Pro Pro Lys Ala Pro Trp Ser Leu Leu Gly 
    450                 455                 460                 


Pro Ala Leu Ser Trp Gln Phe Ser Ser Tyr Val Gly Arg Gly Leu Asn 
465                 470                 475                 480 


Ser Asp Gln Leu Ser Met Leu Arg Asn Lys Leu Phe Gly Gln Asn Cys 
                485                 490                 495     


Arg Thr Glu Asp Pro Leu Leu Ser Trp Ala Asp Phe Thr Lys Arg Glu 
            500                 505                 510         


Ser Pro Pro Gly Lys Leu Pro Phe Trp Thr Trp Leu Asp Lys Ile Leu 
        515                 520                 525             


Glu Leu Val His Asp His Leu Lys Asp Leu Trp Asn Asp Gly Arg Ile 
    530                 535                 540                 


Met Gly Phe Val Ser Arg Ser Gln Glu Arg Arg Leu Leu Lys Lys Thr 
545                 550                 555                 560 


Met Ser Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Glu Gly Gly 
                565                 570                 575     


Ile Thr Cys Ser Trp Val Glu His Gln Asp Asp Asp Lys Val Leu Ile 
            580                 585                 590         


Tyr Ser Val Gln Pro Tyr Thr Lys Glu Val Leu Gln Ser Leu Pro Leu 
        595                 600                 605             


Thr Glu Ile Ile Arg His Tyr Gln Leu Leu Thr Glu Glu Asn Ile Pro 
    610                 615                 620                 


Glu Asn Pro Leu Arg Phe Leu Tyr Pro Arg Ile Pro Arg Asp Glu Ala 
625                 630                 635                 640 


Phe Gly Cys Tyr Tyr Gln Glu Lys Val Asn Leu Gln Glu Arg Arg Lys 
                645                 650                 655     


Tyr Leu Lys His Arg Leu Ile Val Val Ser Asn Arg Gln Val Asp Glu 
            660                 665                 670         


Leu Gln Gln Pro Leu Glu Leu Lys Pro Glu Pro Glu Leu Glu Ser Leu 
        675                 680                 685             


Glu Leu Glu Leu Gly Leu Val Pro Glu Pro Glu Leu Ser Leu Asp Leu 
    690                 695                 700                 


Glu Pro Leu Leu Lys Ala Gly Leu Asp Leu Gly Pro Glu Leu Glu Ser 
705                 710                 715                 720 


Val Leu Glu Ser Thr Leu Glu Pro Val Ile Glu Pro Thr Leu Cys Met 
                725                 730                 735     


Val Ser Gln Thr Val Pro Glu Pro Asp Gln Gly Pro Val Ser Gln Pro 
            740                 745                 750         


Val Pro Glu Pro Asp Leu Pro Cys Asp Leu Arg His Leu Asn Thr Glu 
        755                 760                 765             


Pro Met Glu Ile Phe Arg Asn Cys Val Lys Ile Glu Glu Ile Met Pro 
    770                 775                 780                 


Asn Gly Asp Pro Leu Leu Ala Gly Gln Asn Thr Val Asp Glu Val Tyr 
785                 790                 795                 800 


Val Ser Arg Pro Ser His Phe Tyr Thr Asp Gly Pro Leu Met Pro Ser 
                805                 810                 815     


Asp Phe 
        


<210>  220
<211>  847
<212>  PRT
<213>  Homo sapiens

<400>  220

Met Ala Gln Trp Glu Met Leu Gln Asn Leu Asp Ser Pro Phe Gln Asp 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser His Ser Leu Leu Pro Val Asp Ile Arg 
            20                  25                  30          


Gln Tyr Leu Ala Val Trp Ile Glu Asp Gln Asn Trp Gln Glu Ala Ala 
        35                  40                  45              


Leu Gly Ser Asp Asp Ser Lys Ala Thr Met Leu Phe Phe His Phe Leu 
    50                  55                  60                  


Asp Gln Leu Asn Tyr Glu Cys Gly Arg Cys Ser Gln Asp Pro Glu Ser 
65                  70                  75                  80  


Leu Leu Leu Gln His Asn Leu Arg Lys Phe Cys Arg Asp Ile Gln Asp 
                85                  90                  95      


Pro Thr Gln Leu Ala Glu Met Ile Phe Asn Leu Leu Leu Glu Glu Lys 
            100                 105                 110         


Arg Ile Leu Ile Gln Ala Gln Arg Ala Gln Leu Glu Gln Gly Glu Pro 
        115                 120                 125             


Val Leu Glu Thr Pro Val Glu Ser Gln Gln His Glu Ile Glu Ser Arg 
    130                 135                 140                 


Ile Leu Asp Leu Arg Ala Met Met Glu Lys Leu Val Lys Ser Ile Ser 
145                 150                 155                 160 


Gln Leu Lys Asp Gln Gln Asp Val Phe Cys Phe Arg Tyr Lys Ile Gln 
                165                 170                 175     


Ala Lys Gly Lys Thr Pro Ser Leu Asp Pro His Gln Thr Lys Glu Gln 
            180                 185                 190         


Lys Ile Leu Gln Glu Thr Leu Asn Glu Leu Asp Lys Arg Arg Lys Glu 
        195                 200                 205             


Val Leu Asp Ala Ser Lys Ala Leu Leu Gly Arg Leu Thr Thr Leu Ile 
    210                 215                 220                 


Glu Leu Leu Leu Pro Lys Leu Glu Glu Trp Lys Ala Gln Gln Gln Lys 
225                 230                 235                 240 


Ala Cys Ile Arg Ala Pro Ile Asp His Gly Leu Glu Gln Leu Glu Thr 
                245                 250                 255     


Trp Phe Thr Ala Gly Ala Lys Leu Leu Phe His Leu Arg Gln Leu Leu 
            260                 265                 270         


Lys Glu Leu Lys Gly Leu Ser Cys Leu Val Ser Tyr Gln Asp Asp Pro 
        275                 280                 285             


Leu Thr Lys Gly Val Asp Leu Arg Asn Ala Gln Val Thr Glu Leu Leu 
    290                 295                 300                 


Gln Arg Leu Leu His Arg Ala Phe Val Val Glu Thr Gln Pro Cys Met 
305                 310                 315                 320 


Pro Gln Thr Pro His Arg Pro Leu Ile Leu Lys Thr Gly Ser Lys Phe 
                325                 330                 335     


Thr Val Arg Thr Arg Leu Leu Val Arg Leu Gln Glu Gly Asn Glu Ser 
            340                 345                 350         


Leu Thr Val Glu Val Ser Ile Asp Arg Asn Pro Pro Gln Leu Gln Gly 
        355                 360                 365             


Phe Arg Lys Phe Asn Ile Leu Thr Ser Asn Gln Lys Thr Leu Thr Pro 
    370                 375                 380                 


Glu Lys Gly Gln Ser Gln Gly Leu Ile Trp Asp Phe Gly Tyr Leu Thr 
385                 390                 395                 400 


Leu Val Glu Gln Arg Ser Gly Gly Ser Gly Lys Gly Ser Asn Lys Gly 
                405                 410                 415     


Pro Leu Gly Val Thr Glu Glu Leu His Ile Ile Ser Phe Thr Val Lys 
            420                 425                 430         


Tyr Thr Tyr Gln Gly Leu Lys Gln Glu Leu Lys Thr Asp Thr Leu Pro 
        435                 440                 445             


Val Val Ile Ile Ser Asn Met Asn Gln Leu Ser Ile Ala Trp Ala Ser 
    450                 455                 460                 


Val Leu Trp Phe Asn Leu Leu Ser Pro Asn Leu Gln Asn Gln Gln Phe 
465                 470                 475                 480 


Phe Ser Asn Pro Pro Lys Ala Pro Trp Ser Leu Leu Gly Pro Ala Leu 
                485                 490                 495     


Ser Trp Gln Phe Ser Ser Tyr Val Gly Arg Gly Leu Asn Ser Asp Gln 
            500                 505                 510         


Leu Ser Met Leu Arg Asn Lys Leu Phe Gly Gln Asn Cys Arg Thr Glu 
        515                 520                 525             


Asp Pro Leu Leu Ser Trp Ala Asp Phe Thr Lys Arg Glu Ser Pro Pro 
    530                 535                 540                 


Gly Lys Leu Pro Phe Trp Thr Trp Leu Asp Lys Ile Leu Glu Leu Val 
545                 550                 555                 560 


His Asp His Leu Lys Asp Leu Trp Asn Asp Gly Arg Ile Met Gly Phe 
                565                 570                 575     


Val Ser Arg Ser Gln Glu Arg Arg Leu Leu Lys Lys Thr Met Ser Gly 
            580                 585                 590         


Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Glu Gly Gly Ile Thr Cys 
        595                 600                 605             


Ser Trp Val Glu His Gln Asp Asp Asp Lys Val Leu Ile Tyr Ser Val 
    610                 615                 620                 


Gln Pro Tyr Thr Lys Glu Val Leu Gln Ser Leu Pro Leu Thr Glu Ile 
625                 630                 635                 640 


Ile Arg His Tyr Gln Leu Leu Thr Glu Glu Asn Ile Pro Glu Asn Pro 
                645                 650                 655     


Leu Arg Phe Leu Tyr Pro Arg Ile Pro Arg Asp Glu Ala Phe Gly Cys 
            660                 665                 670         


Tyr Tyr Gln Glu Lys Val Asn Leu Gln Glu Arg Arg Lys Tyr Leu Lys 
        675                 680                 685             


His Arg Leu Ile Val Val Ser Asn Arg Gln Val Asp Glu Leu Gln Gln 
    690                 695                 700                 


Pro Leu Glu Leu Lys Pro Glu Pro Glu Leu Glu Ser Leu Glu Leu Glu 
705                 710                 715                 720 


Leu Gly Leu Val Pro Glu Pro Glu Leu Ser Leu Asp Leu Glu Pro Leu 
                725                 730                 735     


Leu Lys Ala Gly Leu Asp Leu Gly Pro Glu Leu Glu Ser Val Leu Glu 
            740                 745                 750         


Ser Thr Leu Glu Pro Val Ile Glu Pro Thr Leu Cys Met Val Ser Gln 
        755                 760                 765             


Thr Val Pro Glu Pro Asp Gln Gly Pro Val Ser Gln Pro Val Pro Glu 
    770                 775                 780                 


Pro Asp Leu Pro Cys Asp Leu Arg His Leu Asn Thr Glu Pro Met Glu 
785                 790                 795                 800 


Ile Phe Arg Asn Cys Val Lys Ile Glu Glu Ile Met Pro Asn Gly Asp 
                805                 810                 815     


Pro Leu Leu Ala Gly Gln Asn Thr Val Asp Glu Val Tyr Val Ser Arg 
            820                 825                 830         


Pro Ser His Phe Tyr Thr Asp Gly Pro Leu Met Pro Ser Asp Phe 
        835                 840                 845         


<210>  221
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  221

Met Ala Gln Trp Glu Met Leu Gln Asn Leu Asp Ser Pro Phe Gln Asp 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser His Ser Leu Leu Pro Val Asp Ile Arg 
            20                  25                  30          


Gln Tyr Leu Ala Val Trp Ile Glu Asp Gln Asn Trp Gln Glu Ala Ala 
        35                  40                  45              


Leu Gly Ser Asp Asp Ser Lys Ala Thr Met Leu Phe Phe His Phe Leu 
    50                  55                  60                  


Asp Gln Leu Asn Tyr Glu Cys Gly Arg Cys Ser Gln Asp Pro Glu Ser 
65                  70                  75                  80  


Leu Leu Leu Gln His Asn Leu Arg Lys Phe Cys Arg Asp Ile Gln Pro 
                85                  90                  95      


Phe Ser Gln Asp Pro Thr Gln Leu Ala Glu Met Ile Phe Asn Leu Leu 
            100                 105                 110         


Leu Glu Glu Lys Arg Ile Leu Ile Gln Ala Gln Arg Ala Gln Leu Glu 
        115                 120                 125             


Gln Gly Glu Pro Val Leu Glu Thr Pro Val Glu Ser Gln Gln His Glu 
    130                 135                 140                 


Ile Glu Ser Arg Ile Leu Asp Leu Arg Ala Met Met Glu Lys Leu Val 
145                 150                 155                 160 


Lys Ser Ile Ser Gln Leu Lys Asp Gln Gln Asp Val Phe Cys Phe Arg 
                165                 170                 175     


Tyr Lys Ile Gln Ala Lys Gly Lys Thr Pro Ser Leu Asp Pro His Gln 
            180                 185                 190         


Thr Lys Glu Gln Lys Ile Leu Gln Glu Thr Leu Asn Glu Leu Asp Lys 
        195                 200                 205             


Arg Arg Lys Glu Val Leu Asp Ala Ser Lys Ala Leu Leu Gly Arg Leu 
    210                 215                 220                 


Thr Thr Leu Ile Glu Leu Leu Leu Pro Lys Leu Glu Glu Trp Lys Ala 
225                 230                 235                 240 


Gln Gln Gln Lys Ala Cys Ile Arg Ala Pro Ile Asp His Gly Leu Glu 
                245                 250                 255     


Gln Leu Glu Thr Trp 
            260     


<210>  222
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  222

Met Leu Gln Ala Cys Lys Met Glu Gly Phe Pro Leu Val Pro Pro Gln 
1               5                   10                  15      


Pro Ser Glu Asp Leu Val Pro Tyr Asp Thr Asp Leu Tyr Gln Arg Gln 
            20                  25                  30          


Thr His Glu Tyr Tyr Pro Tyr Leu Ser Ser Asp Gly Glu Ser His Ser 
        35                  40                  45              


Asp His Tyr Trp Asp Phe His Pro His His Val His Ser Glu Phe Glu 
    50                  55                  60                  


Ser Phe Ala Glu Asn Asn Phe Thr Glu Leu Gln Ser Val Gln Pro Pro 
65                  70                  75                  80  


Gln Leu Gln Gln Leu Tyr Arg His Met Glu Leu Glu Gln Met His Val 
                85                  90                  95      


Leu Asp Thr Pro Met Val Pro Pro His Pro Ser Leu Gly His Gln Val 
            100                 105                 110         


Ser Tyr Leu Pro Arg Met Cys Leu Gln Tyr Pro Ser Leu Ser Pro Ala 
        115                 120                 125             


Gln Pro Ser Ser Asp Glu Glu Glu Gly Glu Arg Gln Ser Pro Pro Leu 
    130                 135                 140                 


Glu Val Ser Asp Gly Glu Ala Asp Gly Leu Glu Pro Gly Pro Gly Leu 
145                 150                 155                 160 


Leu Pro Gly Glu Thr Gly Ser Lys Lys Lys Ile Arg Leu Tyr Gln Phe 
                165                 170                 175     


Leu Leu Asp Leu Leu Arg Ser Gly Asp Met Lys Asp Ser Ile Trp Trp 
            180                 185                 190         


Val Asp Lys Asp Lys Gly Thr Phe Gln Phe Ser Ser Lys His Lys Glu 
        195                 200                 205             


Ala Leu Ala His Arg Trp Gly Ile Gln Lys Gly Asn Arg Lys Lys Met 
    210                 215                 220                 


Thr Tyr Gln Lys Met Ala Arg Ala Leu Arg Asn Tyr Gly Lys Thr Gly 
225                 230                 235                 240 


Glu Val Lys Lys Val Lys Lys Lys Leu Thr Tyr Gln Phe Ser Gly Glu 
                245                 250                 255     


Val Leu Gly Arg Gly Gly Leu Ala Glu Arg Arg His Pro Pro His 
            260                 265                 270     


<210>  223
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  223

Met Leu Gln Ala Cys Lys Met Glu Gly Phe Pro Leu Val Pro Pro Pro 
1               5                   10                  15      


Ser Glu Asp Leu Val Pro Tyr Asp Thr Asp Leu Tyr Gln Arg Gln Thr 
            20                  25                  30          


His Glu Tyr Tyr Pro Tyr Leu Ser Ser Asp Gly Glu Ser His Ser Asp 
        35                  40                  45              


His Tyr Trp Asp Phe His Pro His His Val His Ser Glu Phe Glu Ser 
    50                  55                  60                  


Phe Ala Glu Asn Asn Phe Thr Glu Leu Gln Ser Val Gln Pro Pro Gln 
65                  70                  75                  80  


Leu Gln Gln Leu Tyr Arg His Met Glu Leu Glu Gln Met His Val Leu 
                85                  90                  95      


Asp Thr Pro Met Val Pro Pro His Pro Ser Leu Gly His Gln Val Ser 
            100                 105                 110         


Tyr Leu Pro Arg Met Cys Leu Gln Tyr Pro Ser Leu Ser Pro Ala Gln 
        115                 120                 125             


Pro Ser Ser Asp Glu Glu Glu Gly Glu Arg Gln Ser Pro Pro Leu Glu 
    130                 135                 140                 


Val Ser Asp Gly Glu Ala Asp Gly Leu Glu Pro Gly Pro Gly Leu Leu 
145                 150                 155                 160 


Pro Gly Glu Thr Gly Ser Lys Lys Lys Ile Arg Leu Tyr Gln Phe Leu 
                165                 170                 175     


Leu Asp Leu Leu Arg Ser Gly Asp Met Lys Asp Ser Ile Trp Trp Val 
            180                 185                 190         


Asp Lys Asp Lys Gly Thr Phe Gln Phe Ser Ser Lys His Lys Glu Ala 
        195                 200                 205             


Leu Ala His Arg Trp Gly Ile Gln Lys Gly Asn Arg Lys Lys Met Thr 
    210                 215                 220                 


Tyr Gln Lys Met Ala Arg Ala Leu Arg Asn Tyr Gly Lys Thr Gly Glu 
225                 230                 235                 240 


Val Lys Lys Val Lys Lys Lys Leu Thr Tyr Gln Phe Ser Gly Glu Val 
                245                 250                 255     


Leu Gly Arg Gly Gly Leu Ala Glu Arg Arg His Pro Pro His 
            260                 265                 270 


<210>  224
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  224

Met Leu Gln Ala Cys Lys Met Glu Gly Phe Pro Leu Val Pro Pro Ala 
1               5                   10                  15      


Ala Arg Arg Arg Ser Ala Cys Thr Ser Ser Cys Trp Thr Cys Ser Ala 
            20                  25                  30          


Ala Ala Thr 
        35  


<210>  225
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  225

Met Leu Gln Ala Cys Lys Met Glu Gly Phe Pro Leu Val Pro Pro Pro 
1               5                   10                  15      


Ser Glu Asp Leu Val Pro Tyr Asp Thr Asp Leu Tyr Gln Arg Gln Thr 
            20                  25                  30          


His Glu Tyr Tyr Pro Tyr Leu Ser Ser Asp Gly Glu Ser His Ser Asp 
        35                  40                  45              


His Tyr Trp Asp Phe His Pro His His Val His Ser Glu Phe Glu Ser 
    50                  55                  60                  


Phe Ala Glu Asn Asn Phe Thr Glu Leu Gln Ser Val Gln Pro Pro Gln 
65                  70                  75                  80  


Leu Gln Gln Leu Tyr Arg His Met Glu Leu Glu Gln Met His Val Leu 
                85                  90                  95      


Asp Thr Pro Met Val Pro Pro His Pro Ser Leu Gly His Gln Val Ser 
            100                 105                 110         


Tyr Leu Pro Arg Met Cys Leu Gln Tyr Pro Ser Leu Ser Pro Ala Gln 
        115                 120                 125             


Pro Ser Ser Asp Glu Glu Glu Gly Glu Arg Gln Ser Pro Pro Leu Glu 
    130                 135                 140                 


Val Ser Asp Gly Glu Ala Asp Gly Leu Glu Pro Gly Pro Gly Leu Leu 
145                 150                 155                 160 


Pro Gly Glu Thr Gly Gly Ala Pro Gly Pro Pro Pro Trp Pro Arg Pro 
                165                 170                 175     


Trp Pro Cys Leu Cys Pro Ala Pro Thr Gln Pro Gly Gln Leu Thr Gln 
            180                 185                 190         


Gln Pro Arg His Arg Val Ala Cys Val Cys Val Cys Met Phe Ala Ser 
        195                 200                 205             


Val Cys Val Leu Trp Gly Cys Leu Trp Leu Ser Leu Cys Val Cys Ile 
    210                 215                 220                 


Cys Cys Val Val His Thr Gly Ile Ser Met Lys Cys Ala Arg Cys Val 
225                 230                 235                 240 


Cys Leu Ser Val Pro 
                245 


<210>  226
<211>  494
<212>  PRT
<213>  Homo sapiens

<400>  226

Met Ala Trp Pro Asn Val Phe Gln Arg Gly Ser Leu Leu Ser Gln Phe 
1               5                   10                  15      


Ser His His His Val Val Val Phe Leu Leu Thr Phe Phe Ser Tyr Ser 
            20                  25                  30          


Leu Leu His Ala Ser Arg Lys Thr Phe Ser Asn Val Lys Val Ser Ile 
        35                  40                  45              


Ser Glu Gln Trp Thr Pro Ser Ala Phe Asn Thr Ser Val Glu Leu Pro 
    50                  55                  60                  


Val Glu Ile Trp Ser Ser Asn His Leu Phe Pro Ser Ala Glu Lys Ala 
65                  70                  75                  80  


Thr Leu Phe Leu Gly Thr Leu Asp Thr Ile Phe Leu Phe Ser Tyr Ala 
                85                  90                  95      


Val Gly Leu Phe Ile Ser Gly Ile Val Gly Asp Arg Leu Asn Leu Arg 
            100                 105                 110         


Trp Val Leu Ser Phe Gly Met Cys Ser Ser Ala Leu Val Val Phe Val 
        115                 120                 125             


Phe Gly Ala Leu Thr Glu Trp Leu Arg Phe Tyr Asn Lys Trp Leu Tyr 
    130                 135                 140                 


Cys Cys Leu Trp Ile Val Asn Gly Leu Leu Gln Ser Thr Gly Trp Pro 
145                 150                 155                 160 


Cys Val Val Ala Val Met Gly Asn Trp Phe Gly Lys Ala Gly Arg Gly 
                165                 170                 175     


Val Val Phe Gly Leu Trp Ser Ala Cys Ala Ser Val Gly Asn Ile Leu 
            180                 185                 190         


Gly Ala Cys Leu Ala Ser Ser Val Leu Gln Tyr Gly Tyr Glu Tyr Ala 
        195                 200                 205             


Phe Leu Val Thr Ala Ser Val Gln Phe Ala Gly Gly Ile Val Ile Phe 
    210                 215                 220                 


Phe Gly Leu Leu Val Ser Pro Glu Glu Ile Gly Leu Ser Gly Ile Glu 
225                 230                 235                 240 


Ala Glu Glu Asn Phe Glu Glu Asp Ser His Arg Pro Leu Ile Asn Gly 
                245                 250                 255     


Gly Glu Asn Glu Asp Glu Tyr Glu Pro Asn Tyr Ser Ile Gln Asp Asp 
            260                 265                 270         


Ser Ser Val Ala Gln Val Lys Ala Ile Ser Phe Tyr Gln Ala Cys Cys 
        275                 280                 285             


Leu Pro Gly Val Ile Pro Tyr Ser Leu Ala Tyr Ala Cys Leu Lys Leu 
    290                 295                 300                 


Val Asn Tyr Ser Phe Phe Phe Trp Leu Pro Phe Tyr Leu Ser Asn Asn 
305                 310                 315                 320 


Phe Gly Trp Lys Glu Ala Glu Ala Asp Lys Leu Ser Ile Trp Tyr Asp 
                325                 330                 335     


Val Gly Gly Ile Ile Gly Gly Thr Leu Gln Gly Phe Ile Ser Asp Val 
            340                 345                 350         


Leu Gln Lys Arg Ala Pro Val Leu Ala Leu Ser Leu Leu Leu Ala Val 
        355                 360                 365             


Gly Ser Leu Ile Gly Tyr Ser Arg Ser Pro Asn Asp Lys Ser Ile Asn 
    370                 375                 380                 


Ala Leu Leu Met Thr Val Thr Gly Phe Phe Ile Gly Gly Pro Ser Asn 
385                 390                 395                 400 


Met Ile Ser Ser Ala Ile Ser Ala Asp Leu Gly Arg Gln Glu Leu Ile 
                405                 410                 415     


Gln Arg Ser Ser Glu Ala Leu Ala Thr Val Thr Gly Ile Val Asp Gly 
            420                 425                 430         


Ser Gly Ser Ile Gly Ala Ala Val Gly Gln Tyr Leu Val Ser Leu Ile 
        435                 440                 445             


Arg Asp Lys Leu Gly Trp Met Trp Val Phe Tyr Phe Phe Ile Leu Met 
    450                 455                 460                 


Thr Ser Cys Thr Ile Val Phe Ile Ser Pro Leu Ile Val Arg Glu Ile 
465                 470                 475                 480 


Phe Ser Leu Val Leu Arg Arg Gln Ala His Ile Leu Arg Glu 
                485                 490                 


<210>  227
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  227

Met Ala Trp Pro Asn Val Phe Gln Arg Gly Ser Leu Leu Ser Gln Phe 
1               5                   10                  15      


Ser His His His Val Val Val Phe Leu Leu Thr Phe Phe Ser Tyr Ser 
            20                  25                  30          


Leu Leu His Ala Ser Arg Lys Thr Phe Ser Asn Val Lys Val Ser Ile 
        35                  40                  45              


Ser Glu Gln Trp Thr Pro Ser Ala Phe Asn Thr Ser Val Glu Leu Pro 
    50                  55                  60                  


Val Glu Ile Trp Ser Ser Asn His Leu Phe Pro Ser Ala Glu Lys Ala 
65                  70                  75                  80  


Thr Leu Phe Leu Gly Thr Leu Asp Thr Ile Phe Leu Phe Ser Tyr Ala 
                85                  90                  95      


Val Gly Leu Phe Ile Ser Gly Ile Val Gly Asp Arg Leu Asn Leu Arg 
            100                 105                 110         


Trp Val Leu Ser Phe Gly Met Cys Ser Ser Ala Leu Val Val Phe Val 
        115                 120                 125             


Phe Gly Ala Leu Thr Glu Trp Leu Arg Phe Tyr Asn Lys Trp Leu Tyr 
    130                 135                 140                 


Cys Cys Leu Trp Ile Val Asn Gly Leu Leu Gln Ser Thr Gly Trp Pro 
145                 150                 155                 160 


Cys Val Val Ala Val Met Gly Asn Trp Phe Gly Lys Ala Gly Arg Gly 
                165                 170                 175     


Val Val Phe Gly Leu Trp Ser Ala Cys Ala Ser Val Gly Asn Ile Leu 
            180                 185                 190         


Gly Ala Cys Leu Ala Ser Ser Val Leu Gln Tyr Gly Tyr Glu Tyr Ala 
        195                 200                 205             


Phe Leu Val Thr Ala Ser Val Gln Phe Ala Gly Gly Ile Val Ile Phe 
    210                 215                 220                 


Phe Gly Leu Leu Val Ser Pro Glu Glu Ile Gly Leu Ser Gly Ile Glu 
225                 230                 235                 240 


Ala Glu Glu Asn Phe Glu Glu Asp Ser His Arg Pro Leu Ile Asn Gly 
                245                 250                 255     


Gly Glu Asn Glu Asp Glu Tyr Glu Pro Asn Tyr Ser Ile Gln Asp Asp 
            260                 265                 270         


Ser Ser Val Ala Gln Val Lys Ala Ile Ser Phe Tyr Gln Ala Cys Cys 
        275                 280                 285             


Leu Pro Gly Val Ile Pro Tyr Ser Leu Ala Tyr Ala Cys Leu Lys Leu 
    290                 295                 300                 


Val Asn Tyr Ser Phe Phe Phe Trp Leu Pro Phe Tyr Leu Ser Asn Asn 
305                 310                 315                 320 


Phe Gly Trp Lys Glu Ala Glu Ala Asp Lys Leu Ser Ile Trp Tyr Asp 
                325                 330                 335     


Val Gly Gly Ile Ile Val Phe Ser Val Ser Asp Pro Gly Gln Ala Arg 
            340                 345                 350         


Met Asp Val Gly Phe Leu Leu Phe His Ser His Asp Lys Leu Tyr Asn 
        355                 360                 365             


Cys Val Tyr Leu Ala Ile Asn Ser Glu Gly Asn Ile Leu Ser Arg Ala 
    370                 375                 380                 


Lys Glu Thr Gly Ser His Ile Glu Gly Val Thr Gly Ala Arg Glu Thr 
385                 390                 395                 400 


Glu Arg Thr Met Ser Ala Thr Ser Gly Pro Leu Gly Leu Arg Val Cys 
                405                 410                 415     


Pro Asn Leu Gly Leu Ser Arg Ser Ser Ser Leu Ile Leu Asp Cys Gln 
            420                 425                 430         


Ala Ser Leu Asn Thr Ala Ser His Leu Arg Cys 
        435                 440             


<210>  228
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  228

Gly Leu Phe Ile Ser Gly Ile Val Gly Asp Arg Leu Asn Leu Arg Trp 
1               5                   10                  15      


Val Leu Ser Phe Gly Met Cys Ser Ser Ala Leu Val Val Phe Val Phe 
            20                  25                  30          


Gly Ala Leu Thr Glu Trp Leu Arg Phe Tyr Asn Lys Trp Leu Tyr Cys 
        35                  40                  45              


Cys Leu Trp Ile Val Asn Gly Leu Leu Gln Ser Thr Gly Trp Pro Cys 
    50                  55                  60                  


Val Val Ala Val Met Gly Asn Trp Phe Gly Lys Ala Gly Arg Gly Val 
65                  70                  75                  80  


Val Phe Gly Leu Trp Ser Ala Cys Ala Ser Val Gly Asn Ile Leu Gly 
                85                  90                  95      


Ala Cys Leu Ala Ser Ser Val Leu Gln Tyr Gly Tyr Glu Ile Cys Lys 
            100                 105                 110         


Asp His Leu Ser Pro Leu Ser Ser Ser Met Pro Phe Trp 
        115                 120                 125 


<210>  229
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  229

Met Ala Trp Pro Asn Val Phe Gln Arg Gly Ser Leu Leu Ser Gln Phe 
1               5                   10                  15      


Ser His His His Val Val Val Phe Leu Leu Thr Phe Phe Ser Tyr Ser 
            20                  25                  30          


Leu Leu His Ala Ser Arg Lys Thr Phe Ser Asn Val Lys Val Ser Ile 
        35                  40                  45              


Ser Glu Gln Trp Thr Pro Ser Ala Phe Asn Thr Ser Val Glu Leu Pro 
    50                  55                  60                  


Val Glu 
65      


<210>  230
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  230

Gln Arg Ser Ser Glu Ala Leu Ala Thr Val Thr Gly Ile Val Asp Gly 
1               5                   10                  15      


Ser Gly Ser Ile Gly Ala Ala Val Gly Gln Thr Ser Cys Thr Ile Val 
            20                  25                  30          


Phe Ile Ser Pro Leu Ile Val Arg Glu Ile Phe Ser Leu Val Leu Arg 
        35                  40                  45              


Arg Gln Ala His Ile Leu Arg Glu 
    50                  55      


<210>  231
<211>  151
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  231

Xaa Leu Leu Leu Ala Val Gly Ser Leu Ile Gly Tyr Ser Arg Ser Pro 
1               5                   10                  15      


Asn Asp Lys Ser Ile Asn Ala Leu Leu Met Thr Val Thr Gly Phe Phe 
            20                  25                  30          


Ile Gly Gly Pro Ser Asn Met Ile Ser Ser Ala Ile Ser Ala Asp Leu 
        35                  40                  45              


Gly Arg Gln Glu Leu Ile Gln Arg Ser Ser Glu Ala Leu Ala Thr Val 
    50                  55                  60                  


Thr Gly Ile Val Asp Gly Ser Gly Ser Ile Gly Ala Ala Val Gly Gln 
65                  70                  75                  80  


Tyr Leu Val Ser Leu Ile Arg Asp Lys Leu Gly Trp Met Trp Val Phe 
                85                  90                  95      


Tyr Phe Phe Ile Leu Met Thr Gly Ser His Ile Glu Gly Val Thr Gly 
            100                 105                 110         


Ala Arg Glu Thr Glu Arg Thr Met Ser Ala Thr Ser Gly Pro Leu Gly 
        115                 120                 125             


Leu Arg Val Cys Pro Asn Leu Gly Leu Ser Arg Ser Ser Ser Leu Ile 
    130                 135                 140                 


Leu Asp Cys Gln Ala Ser Leu 
145                 150     


<210>  232
<211>  178
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  232

Xaa Ala Glu Lys Ala Thr Leu Phe Leu Gly Thr Leu Asp Thr Ile Phe 
1               5                   10                  15      


Leu Phe Ser Tyr Ala Val Gly Leu Phe Ile Ser Gly Ile Val Gly Asp 
            20                  25                  30          


Arg Leu Asn Leu Arg Trp Val Leu Ser Phe Gly Met Cys Ser Ser Ala 
        35                  40                  45              


Leu Val Val Phe Val Phe Gly Ala Leu Thr Glu Trp Leu Arg Phe Tyr 
    50                  55                  60                  


Asn Lys Trp Leu Tyr Cys Cys Leu Trp Ile Val Asn Gly Leu Leu Gln 
65                  70                  75                  80  


Ser Thr Gly Trp Pro Cys Val Val Ala Val Met Gly Asn Trp Phe Gly 
                85                  90                  95      


Lys Ala Gly Arg Gly Val Val Phe Gly Leu Trp Ser Ala Cys Ala Ser 
            100                 105                 110         


Val Gly Asn Ile Leu Gly Ala Cys Leu Ala Ser Ser Val Leu Gln Tyr 
        115                 120                 125             


Gly Tyr Glu Tyr Ser Leu Ala Tyr Ala Cys Leu Lys Leu Val Asn Tyr 
    130                 135                 140                 


Ser Phe Phe Phe Trp Leu Pro Phe Tyr Leu Ser Asn Asn Phe Gly Trp 
145                 150                 155                 160 


Lys Glu Ala Glu Ala Asp Lys Leu Ser Ile Trp Tyr Asp Val Gly Gly 
                165                 170                 175     


Ile Ile 
        


<210>  233
<211>  98
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  233

Xaa Ser Ala Ile Ser Ala Asp Leu Gly Arg Gln Glu Leu Ile Gln Arg 
1               5                   10                  15      


Ser Ser Glu Ala Leu Ala Thr Val Thr Gly Ile Val Asp Gly Ser Gly 
            20                  25                  30          


Ser Ile Gly Ala Ala Val Gly Gln Glu Thr Gly Ser His Ile Glu Gly 
        35                  40                  45              


Val Thr Gly Ala Arg Glu Thr Glu Arg Thr Met Ser Ala Thr Ser Gly 
    50                  55                  60                  


Pro Leu Gly Leu Arg Val Cys Pro Asn Leu Gly Leu Ser Arg Ser Ser 
65                  70                  75                  80  


Ser Leu Ile Leu Asp Cys Gln Ala Ser Leu Asn Thr Ala Ser His Leu 
                85                  90                  95      


Arg Cys 
        


<210>  234
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  234

Leu Ser Leu Leu Leu Ala Val Gly Ser Leu Ile Gly Tyr Ser Arg Ser 
1               5                   10                  15      


Pro Asn Asp Lys Ser Ile Asn Ala Leu Leu Met Thr Val Thr Gly Phe 
            20                  25                  30          


Phe Ile Gly Gly Pro Ser Asn Met Ile Ser Ser Ala Ile Ser Ala Asp 
        35                  40                  45              


Leu Gly Arg Gln Glu Leu Ile Gln Arg Ser Ser Glu Ala Leu Ala Thr 
    50                  55                  60                  


Val Thr Gly Ile Val Asp Gly Ser Gly Ser Ile Gly Ala Ala Val Gly 
65                  70                  75                  80  


Gln Tyr Leu Val Ser Leu Ile Arg Asp Lys Leu Gly Trp Met Trp Val 
                85                  90                  95      


Phe Tyr Phe Phe Ile Leu Met Glu Thr Gly Ser His Ile Glu Gly Val 
            100                 105                 110         


Thr Gly Ala Arg Glu Thr Glu Arg Thr Met Ser Ala Thr Ser Gly Pro 
        115                 120                 125             


Leu Gly Leu Arg Val Cys Pro Asn Leu Gly Leu Ser Arg Ser Ser Ser 
    130                 135                 140                 


Leu Ile Leu Asp Cys Gln Ala Ser Leu Asn Thr Ala Ser His Leu Arg 
145                 150                 155                 160 


Cys 
    


<210>  235
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  235

Met Ala Trp Pro Asn Val Phe Gln Arg Gly Ser Leu Leu Ser Gln Phe 
1               5                   10                  15      


Ser His His His Val Val Val Phe Leu Leu Thr Phe Phe Ser Tyr Ser 
            20                  25                  30          


Leu Leu His Ala Ser Arg Lys Thr Phe Ser Asn Val Lys Val Ser Ile 
        35                  40                  45              


Ser Glu Gln Trp Thr Pro Ser Ala Phe Asn Thr Ser Val Glu Leu Pro 
    50                  55                  60                  


Val Glu Ile Trp Ser Ser Asn His Leu Phe Pro Ser Ala Glu Lys Ala 
65                  70                  75                  80  


Thr Leu Phe Leu Gly Thr Leu Asp Thr Ile Phe Leu Phe Ser Tyr Ala 
                85                  90                  95      


Val Gly Leu Phe Ile Ser Gly Ile Val Gly Asp Arg Leu Asn Leu Arg 
            100                 105                 110         


Trp Val Leu Ser Phe Gly Met Cys Ser Ser Ala Leu Val Val Phe Val 
        115                 120                 125             


Phe Gly Ala Leu Thr Glu Trp Leu Arg Phe Tyr Asn Lys Trp Leu Tyr 
    130                 135                 140                 


Cys Cys Leu Trp Ile Val Asn Gly Leu Leu Gln Ser Thr Gly Trp Pro 
145                 150                 155                 160 


Cys Val Val Ala Val Met Gly Asn Trp Phe Gly Lys Ala Gly Arg Gly 
                165                 170                 175     


Val Val Phe Gly Leu Trp Ser Ala Cys Ala Ser Val Gly Asn Ile Leu 
            180                 185                 190         


Gly Ala Cys Leu Ala Ser Ser Val Leu Gln Tyr Gly Tyr Glu Val Ser 
        195                 200                 205             


Arg Val Leu Arg Gln Lys Lys Thr Leu Lys Lys Thr His Thr Gly His 
    210                 215                 220                 


<210>  236
<211>  193
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  236

Xaa Ile Phe Phe Gly Leu Leu Val Ser Pro Glu Glu Ile Gly Leu Ser 
1               5                   10                  15      


Gly Ile Glu Ala Glu Glu Asn Phe Glu Glu Asp Ser His Arg Pro Leu 
            20                  25                  30          


Ile Asn Gly Gly Glu Asn Glu Asp Glu Tyr Glu Pro Asn Tyr Ser Ile 
        35                  40                  45              


Gln Asp Asp Ser Ser Val Ala Gln Val Lys Ala Ile Ser Phe Tyr Gln 
    50                  55                  60                  


Ala Cys Cys Leu Pro Gly Val Ile Pro Tyr Ser Leu Ala Tyr Ala Cys 
65                  70                  75                  80  


Leu Lys Leu Val Asn Tyr Ser Phe Phe Phe Trp Leu Pro Phe Tyr Leu 
                85                  90                  95      


Ser Asn Asn Phe Gly Trp Lys Glu Ala Glu Ala Asp Lys Leu Ser Ile 
            100                 105                 110         


Trp Tyr Asp Val Gly Gly Ile Ile Gly Gly Thr Leu Gln Gly Phe Ile 
        115                 120                 125             


Ser Asp Val Leu Gln Lys Arg Ala Pro Val Leu Ala Leu Ser Leu Leu 
    130                 135                 140                 


Leu Ala Val Gly Ser Leu Ile Gly Tyr Ser Leu Phe Ser Val Ser Asp 
145                 150                 155                 160 


Pro Gly Gln Ala Arg Met Asp Val Gly Phe Leu Leu Phe His Ser His 
                165                 170                 175     


Asp Lys Leu Tyr Asn Cys Val Tyr Leu Ala Ile Asn Ser Glu Gly Asn 
            180                 185                 190         


Ile 
    


<210>  237
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  237

Met Ala Trp Pro Asn Val Phe Gln Arg Gly Ser Leu Leu Ser Gln Phe 
1               5                   10                  15      


Ser His His His Val Val Val Phe Leu Leu Thr Phe Phe Arg Cys Leu 
            20                  25                  30          


Ser Leu Val Arg Ser Gln Asn Gly Cys Val Ser Thr Thr Asn Gly Cys 
        35                  40                  45              


Thr Ala Ala Cys Gly Leu 
    50                  


<210>  238
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  238

Gly Trp Lys Glu Ala Glu Ala Asp Lys Leu Ser Ile Trp Tyr Asp Val 
1               5                   10                  15      


Gly Gly Ile Ile Val Phe Ser Val Ser Asp Pro Gly Gln Ala Arg Met 
            20                  25                  30          


Asp Val Gly Phe Leu Leu Phe His Ser His Asp Lys Leu Tyr Asn Cys 
        35                  40                  45              


Val Tyr Leu Ala Ile Asn Ser Glu Gly Asn Ile Leu Ser Arg Ala Lys 
    50                  55                  60                  


Glu Thr Gly Ser His Ile Glu Gly Val Thr Gly Ala Arg Glu Thr Glu 
65                  70                  75                  80  


Arg Thr Met Ser Ala Thr Ser Gly Pro Leu Gly Leu Arg Val Cys Pro 
                85                  90                  95      


Asn Leu Gly Leu Ser Arg Ser Ser Ser Leu Ile Leu Asp Cys Gln Ala 
            100                 105                 110         


Ser Leu Asn Thr Ala Ser His Leu Arg Cys 
        115                 120         


<210>  239
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  239

Met Ala Trp Pro Asn Val Phe Gln Arg Gly Ser Leu Leu Ser Gln Phe 
1               5                   10                  15      


Ser His His His Val Val Val Phe Leu Leu Thr Phe Phe Ser Tyr Ser 
            20                  25                  30          


Leu Leu His Ala Ser Arg Lys Thr Phe Ser Asn Val Lys Val Ser Ile 
        35                  40                  45              


Ser Glu Gln Trp Thr Pro Ser Ala Phe Asn Thr Ser Val Glu Leu Pro 
    50                  55                  60                  


Val Glu Ile Trp Ser Ser Asn His Leu Phe Pro Ser Ala Glu Lys Ala 
65                  70                  75                  80  


Thr Leu Phe Leu Gly Thr Leu Asp Thr Ile Phe Leu Phe Ser Tyr Ala 
                85                  90                  95      


Val Gly Leu Phe Ile Ser Gly Ile Val Gly Asp Arg Leu Asn Leu Arg 
            100                 105                 110         


Trp Val Leu Ser Phe Gly Met Cys Ser Ser Ala Leu Val Tyr Ala Phe 
        115                 120                 125             


Leu Val Thr Ala Ser Val Gln Phe Ala Gly Gly Ile Val Ile Phe Phe 
    130                 135                 140                 


Gly Leu Leu Val Ser Pro Glu Glu Ile 
145                 150             


<210>  240
<211>  81
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  240

Xaa Tyr Ser Ile Gln Asp Asp Ser Ser Val Ala Gln Val Lys Ala Ile 
1               5                   10                  15      


Ser Phe Tyr Gln Ala Cys Cys Leu Pro Gly Val Ile Pro Tyr Leu Val 
            20                  25                  30          


Ser Leu Ile Arg Asp Lys Leu Gly Trp Met Trp Val Phe Tyr Phe Phe 
        35                  40                  45              


Ile Leu Met Thr Ser Cys Thr Ile Val Phe Ile Ser Pro Leu Ile Val 
    50                  55                  60                  


Arg Glu Ile Phe Ser Leu Val Leu Arg Arg Gln Ala His Ile Leu Arg 
65                  70                  75                  80  


Glu 
    


<210>  241
<211>  150
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  241

Xaa Phe Pro Ser Ala Glu Lys Ala Thr Leu Phe Leu Gly Thr Leu Asp 
1               5                   10                  15      


Thr Ile Phe Leu Phe Ser Tyr Ala Val Gly Leu Phe Ile Ser Gly Ile 
            20                  25                  30          


Val Gly Asp Arg Leu Asn Leu Arg Trp Val Leu Ser Phe Gly Met Cys 
        35                  40                  45              


Ser Ser Ala Leu Val Val Phe Val Phe Gly Ala Leu Thr Glu Trp Leu 
    50                  55                  60                  


Arg Phe Tyr Asn Lys Trp Leu Tyr Cys Cys Leu Trp Ile Val Asn Gly 
65                  70                  75                  80  


Leu Leu Gln Ser Thr Gly Trp Pro Cys Val Val Ala Val Met Gly Asn 
                85                  90                  95      


Trp Phe Gly Lys Ala Gly Arg Gly Val Val Phe Gly Leu Trp Ser Ala 
            100                 105                 110         


Cys Ala Ser Val Gly Asn Ile Leu Gly Ala Cys Leu Ala Ser Ser Val 
        115                 120                 125             


Leu Gln Tyr Gly Tyr Glu Ile Cys Lys Asp His Leu Ser Pro Leu Ser 
    130                 135                 140                 


Ser Ser Met Pro Phe Trp 
145                 150 


<210>  242
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  242

Met Ala Trp Pro Asn Val Phe Gln Arg Gly Ser Leu Leu Ser Gln Phe 
1               5                   10                  15      


Ser His His His Val Val Val Phe Leu Leu Thr Phe Phe Ser Tyr Ser 
            20                  25                  30          


Leu Leu His Ala Ser Arg Lys Thr Phe Ser Asn Val Lys Val Ser Ile 
        35                  40                  45              


Ser Glu Gln Trp Thr Pro Ser Ala Phe Asn Thr Ser Val Glu Leu Pro 
    50                  55                  60                  


Val Glu Ile Trp Ser Ser Asn His Leu Phe Pro Ser Ala Glu Lys Ala 
65                  70                  75                  80  


Thr Leu Phe Leu Gly Thr Leu Asp Thr Ile Phe Leu Phe Ser Tyr Ala 
                85                  90                  95      


Val Gly Leu Phe Ile Ser Gly Ile Val Gly Asp Arg Leu Asn Leu Arg 
            100                 105                 110         


Trp Val Leu Ser Phe Gly Met Cys Ser Ser Ala Leu Val Val Phe Val 
        115                 120                 125             


Phe Gly Ala Leu Thr Glu Trp Leu Arg Phe Tyr Asn Lys Trp Leu Tyr 
    130                 135                 140                 


Cys Cys Leu Trp Ile Val Asn Gly Leu Leu Gln Ser Thr Gly Trp Pro 
145                 150                 155                 160 


Cys Val Val Ala Val Met Gly Asn Trp Phe Gly Lys Ala Gly Arg Gly 
                165                 170                 175     


Val Val Phe Gly Leu Trp Ser Ala Cys Ala Ser Val Gly Asn Ile Leu 
            180                 185                 190         


Gly Ala Cys Leu Ala Ser Ser Val Leu Gln Tyr Gly Tyr Glu Tyr Ala 
        195                 200                 205             


Phe Leu Val Thr Ala Ser Val Gln Phe Ala Gly Gly Ile Val Ile Phe 
    210                 215                 220                 


Phe Gly Leu Leu Val Ser Pro Glu Glu Ile Gly Leu Ser Gly Ile Glu 
225                 230                 235                 240 


Ala Glu Glu Asn Phe Glu Glu Asp Ser His Arg Pro Leu Ile Asn Gly 
                245                 250                 255     


Gly Glu Asn Glu Asp Glu Tyr Glu Pro Asn Tyr Ser Ile Gln Asp Asp 
            260                 265                 270         


Ser Ser Val Ala Gln Val Lys Ala Ile Ser Phe Tyr Gln Ala Cys Cys 
        275                 280                 285             


Leu Pro Gly Val Ile Pro Tyr Ser Leu Ala Tyr Ala Cys Leu Lys Leu 
    290                 295                 300                 


Val Asn Tyr Ser Phe Phe Phe Trp Leu Pro Phe Tyr Leu Ser Asn Asn 
305                 310                 315                 320 


Phe Gly Trp Lys Glu Ala Glu Ala Asp Lys Leu Ser Ile Trp Tyr Asp 
                325                 330                 335     


Val Gly Gly Ile Ile Gly Gly Thr Leu Gln Gly Phe Ile Ser Asp Val 
            340                 345                 350         


Leu Gln Lys Arg Ala Pro Val Leu Ala Leu Ser Leu Leu Leu Ala Val 
        355                 360                 365             


Gly Ser Leu Ile Gly Tyr Ser Arg Phe Phe Ile Gly Gly Pro Ser Asn 
    370                 375                 380                 


Met Ile Ser Ser Ala Ile Ser Ala Asp Leu Gly Arg Gln Glu Leu Ile 
385                 390                 395                 400 


Gln Arg Ser Ser Glu Ala Leu Ala Thr Val Thr Gly Ile Val Asp Gly 
                405                 410                 415     


Ser Gly Ser Ile Gly Ala Ala Val Gly Gln Tyr Leu Val Ser Leu Ile 
            420                 425                 430         


Arg Asp Lys Leu Gly Trp Met Trp Val Phe Tyr Phe Phe Ile Leu Met 
        435                 440                 445             


Thr Ser Cys Thr Ile Val Phe Ile Ser Pro Leu Ile Val Arg Glu Ile 
    450                 455                 460                 


Phe Ser Leu Val Leu Arg Arg Gln Ala His Ile Leu Arg Glu 
465                 470                 475             


<210>  243
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  243

Met Ala Trp Pro Asn Val Phe Gln Arg Gly Ser Leu Leu Ser 
1               5                   10                  


<210>  244
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  244

Met Cys Asp Arg Asn Gly Gly Arg Arg Leu Arg Gln Trp Leu Ile Glu 
1               5                   10                  15      


Gln Ile Asp Ser Ser Met Tyr Pro Gly Leu Ile Trp Glu Asn Glu Glu 
            20                  25                  30          


Lys Ser Met Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln Asp Tyr 
        35                  40                  45              


Asn Gln Glu Val Asp Ala Ser Ile Phe Lys Ala Trp Ala Val Phe Lys 
    50                  55                  60                  


Gly Lys Phe Lys Glu Gly Asp Lys Ala Glu Pro Ala Thr Trp Lys Thr 
65                  70                  75                  80  


Arg Leu Arg Cys Ala Leu Asn Lys Ser Pro Asp Phe Glu Glu Val Thr 
                85                  90                  95      


Asp Arg Ser Gln Leu Asp Ile Ser Glu Pro Tyr Lys Val Tyr Arg Ile 
            100                 105                 110         


Val Pro Glu Glu Glu Gln Lys Cys Lys Leu Gly Val Ala Thr Ala Gly 
        115                 120                 125             


Cys Val Asn Glu Val Thr Glu Met Glu Cys Gly Arg Ser Glu Ile Asp 
    130                 135                 140                 


Glu Leu Ile Lys Glu Pro Ser Val Asp Asp Tyr Met Gly Met Ile Lys 
145                 150                 155                 160 


Arg Ser Pro Ser Pro Pro Glu Ala Cys Arg Ser Gln Leu Leu Pro Asp 
                165                 170                 175     


Trp Trp Ala Gln Gln Pro Ser Thr Gly Val Pro Leu Val Thr Gly Tyr 
            180                 185                 190         


Thr Thr Tyr Asp Ala His His Ser Ala Phe Ser Gln Met Val Ile Ser 
        195                 200                 205             


Phe Tyr Tyr Gly Gly Lys Leu Val Gly Gln Ala Thr Thr Thr Cys Pro 
    210                 215                 220                 


Glu Gly Cys Arg Leu Ser Leu Ser Gln Pro Gly Leu Pro Gly Thr Lys 
225                 230                 235                 240 


Leu Tyr Gly Pro Glu Gly Leu Glu Leu Val Arg Phe Pro Pro Ala Asp 
                245                 250                 255     


Ala Ile Pro Ser Glu Arg Gln Arg Gln Val Thr Arg Lys Leu Phe Gly 
            260                 265                 270         


His Leu Glu Arg Gly Val Leu Leu His Ser Ser Arg Gln Gly Val Phe 
        275                 280                 285             


Val Lys Arg Leu Cys Gln Gly Arg Val Phe Cys Ser Gly Asn Ala Val 
    290                 295                 300                 


Val Cys Lys Gly Arg Pro Asn Lys Leu Glu Arg Asp Glu Val Val Gln 
305                 310                 315                 320 


Val Phe Asp Thr Ser Gln Phe Phe Arg Glu Leu Gln Gln Phe Tyr Asn 
                325                 330                 335     


Ser Gln Gly Arg Leu Pro Asp Gly Arg Val Val Leu Cys Phe Gly Glu 
            340                 345                 350         


Glu Phe Pro Asp Met Ala Pro Leu Arg Ser Lys Leu Ile Leu Val Gln 
        355                 360                 365             


Ile Glu Gln Leu Tyr Val Arg Gln Leu Ala Glu Glu Ala Gly Lys Ser 
    370                 375                 380                 


Cys Gly Ala Gly Ser Val Met Gln Ala Pro Glu Glu Pro Pro Pro Asp 
385                 390                 395                 400 


Gln Val Phe Arg Met Phe Pro Asp Ile Cys Ala Ser His Gln Arg Ser 
                405                 410                 415     


Phe Phe Arg Glu Asn Gln Gln Ile Thr Val 
            420                 425     


<210>  245
<211>  152
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  245

Xaa Ala Trp Ala Val Phe Lys Gly Lys Phe Lys Glu Gly Asp Lys Ala 
1               5                   10                  15      


Glu Pro Ala Thr Trp Lys Thr Arg Leu Arg Cys Ala Leu Asn Lys Ser 
            20                  25                  30          


Pro Asp Phe Glu Glu Val Thr Asp Arg Ser Gln Leu Asp Ile Ser Glu 
        35                  40                  45              


Pro Tyr Lys Val Tyr Arg Ile Val Pro Glu Glu Glu Gln Lys Cys Lys 
    50                  55                  60                  


Leu Gly Val Ala Thr Ala Gly Cys Val Asn Glu Val Thr Glu Met Glu 
65                  70                  75                  80  


Cys Gly Arg Ser Glu Ile Asp Glu Leu Ile Lys Glu Ser Cys Ser Ser 
                85                  90                  95      


Ser Ile Thr Ala Arg Ala Gly Phe Leu Thr Ala Gly Trp Cys Cys Ala 
            100                 105                 110         


Leu Gly Lys Ser Phe Arg Ile Trp Pro Pro Cys Ala Pro Asn Ser Phe 
        115                 120                 125             


Ser Cys Arg Leu Ser Ser Cys Met Ser Gly Asn Trp Gln Lys Arg Leu 
    130                 135                 140                 


Gly Arg Ala Val Glu Pro Ala Leu 
145                 150         


<210>  246
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  246

Met Cys Asp Arg Asn Gly Gly Arg Arg Leu Arg Gln Trp Leu Ile Glu 
1               5                   10                  15      


Gln Ile Asp Ser Ser Met Tyr Pro Gly Leu Ile Trp Glu Asn Glu Glu 
            20                  25                  30          


Lys Ser Met Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln Asp Tyr 
        35                  40                  45              


Asn Gln Glu Val Asp Ala Ser Ile Phe Lys Ala Trp Ala Val Phe Lys 
    50                  55                  60                  


Gly Lys Phe Lys Glu Gly Asp Lys Ala Glu Pro Ala Thr Trp Lys Thr 
65                  70                  75                  80  


Arg Leu Arg Cys Ala Leu Asn Lys Ser Pro Asp Phe Glu Glu Val Thr 
                85                  90                  95      


Asp Arg Ser Gln Leu Asp Ile Ser Glu Pro Tyr Lys Val Tyr Arg Ile 
            100                 105                 110         


Val Pro Glu Glu Glu Gln Lys Cys Lys Leu Gly Val Ala Thr Ala Gly 
        115                 120                 125             


Cys Val Asn Glu Val Thr Glu Met Glu Cys Gly Arg Ser Glu Ile Asp 
    130                 135                 140                 


Glu Leu Ile Lys Glu Pro Ser Val Asp Asp Tyr Met Gly Met Ile Lys 
145                 150                 155                 160 


Arg Ser Pro Ser Pro Pro Glu Ala Cys Arg Ser Gln Leu Leu Pro Asp 
                165                 170                 175     


Trp Trp Ala Gln Gln Pro Ser Thr Gly Val Pro Leu Val Thr Gly Tyr 
            180                 185                 190         


Thr Thr Tyr Asp Ala His His Ser Ala Phe Ser Gln Met Val Ile Ser 
        195                 200                 205             


Phe Tyr Tyr Gly Gly Lys Leu Val Gly Gln Ala Thr Thr Thr Cys Pro 
    210                 215                 220                 


Glu Gly Cys Arg Leu Ser Leu Ser Gln Pro Gly Leu Pro Gly Thr Lys 
225                 230                 235                 240 


Leu Tyr Gly Pro Glu Gly Leu Glu Leu Val Arg Phe Pro Pro Ala Asp 
                245                 250                 255     


Ala Ile Pro Ser Glu Arg Gln Arg Gln Val Thr Arg Lys Leu Phe Gly 
            260                 265                 270         


His Leu Glu Arg Gly Val Leu Leu His Ser Ser Arg Gln Gly Val Phe 
        275                 280                 285             


Val Lys Arg Leu Cys Gln Gly Arg Val Phe Cys Ser Gly Asn Ala Val 
    290                 295                 300                 


Val Cys Lys Gly Arg Pro Asn Lys Leu Glu Arg Asp Glu Val Val Gln 
305                 310                 315                 320 


Val Phe Asp Thr Ser Gln Phe Phe 
                325             


<210>  247
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  247

Met Gly Ala Ser Trp Trp Ala Arg Pro Pro Pro Pro Ala Pro 
1               5                   10                  


<210>  248
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  248

Met Val Ile Ser Phe Tyr Tyr Gly Gly Lys Leu Val Gly Gln Ala Thr 
1               5                   10                  15      


Thr Thr Cys Pro Glu Gly Cys Arg Leu Ser Leu Ser Gln Pro Gly Leu 
            20                  25                  30          


Pro Gly Thr Lys Leu Tyr Gly Pro Glu Gly Leu Glu Leu Val Arg Phe 
        35                  40                  45              


Pro Pro Ala Asp Ala Ile Pro Ser Glu Arg Gln Arg Gln Val Thr Arg 
    50                  55                  60                  


Lys Leu Phe Gly His Leu Glu Arg Gly Val Leu Leu His Ser Ser Arg 
65                  70                  75                  80  


Gln Gly Val Phe Val Lys Arg Leu Cys Gln Gly Arg Val Phe Cys Ser 
                85                  90                  95      


Gly Asn Ala Val Val Cys Lys Gly Arg Pro Asn Lys Leu Glu Arg Asp 
            100                 105                 110         


Glu Val Val Gln Val Phe Asp Thr Ser Gln Phe Phe Arg Glu Leu Gln 
        115                 120                 125             


Gln Phe Tyr Asn Ser Gln Gly Arg Leu Pro Asp Gly Arg Val Val Leu 
    130                 135                 140                 


Cys Phe Gly Glu Glu Phe Pro Asp Met Ala Pro Leu Arg Ser Lys Leu 
145                 150                 155                 160 


Ile Leu Val Gln Ile Glu Gln Leu Tyr Val Arg Gln Leu Ala Glu Glu 
                165                 170                 175     


Ala Gly Lys Ser Cys Gly Ala Gly Ser Val Met Gln Ala Pro Glu Glu 
            180                 185                 190         


Pro Pro Pro Asp Gln Val Phe Arg Met Phe Pro Asp Ile Cys Ala Ser 
        195                 200                 205             


His Gln Arg Ser Phe Phe Arg Glu Asn Gln Gln Ile Thr Val 
    210                 215                 220         


<210>  249
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  249

Met Cys Asp Arg Asn Gly Gly Arg Arg Leu Arg Gln Trp Leu Ile Glu 
1               5                   10                  15      


Gln Ile Asp Ser Ser Met Tyr Pro Gly Leu Ile Trp Glu Asn Glu Glu 
            20                  25                  30          


Lys Ser Met Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln Asp Tyr 
        35                  40                  45              


Asn Gln Glu Val Asp Ala Ser Ile Phe Lys Ala Trp Ala Val Phe Lys 
    50                  55                  60                  


Gly Lys Phe Lys Glu Gly Asp Lys Ala Glu Pro Ala Thr Trp Lys Thr 
65                  70                  75                  80  


Arg Leu Arg Cys Ala Leu Asn Lys Ser Pro Asp Phe Glu Glu Val Thr 
                85                  90                  95      


Asp Arg Ser Gln Leu Asp Ile Ser Glu Pro Tyr Lys Val Tyr Arg Ile 
            100                 105                 110         


Val Pro Glu Glu Glu Gln Lys Cys Lys Leu Gly Val Ala Thr Ala Gly 
        115                 120                 125             


Cys Val Asn Glu Val Thr Glu Met Glu Cys Gly Arg Ser Glu Ile Asp 
    130                 135                 140                 


Glu Leu Ile Lys Glu Pro Ser Val Asp Asp Tyr Met Gly Met Ile 
145                 150                 155                 


<210>  250
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  250

Met Val Ile Ser Phe Tyr Tyr Gly Gly Lys Leu Val Gly Gln Ala Thr 
1               5                   10                  15      


Thr Thr Cys Pro Glu Gly Cys Arg Leu Ser Leu Ser Gln Pro Gly Leu 
            20                  25                  30          


Pro Gly Thr Lys Leu Tyr Gly Pro Glu Gly Leu Glu Leu Val Arg Phe 
        35                  40                  45              


Pro Pro Ala Asp Ala Ile Pro Ser Glu Arg Gln Arg Gln Val Thr Arg 
    50                  55                  60                  


Lys Leu Phe Gly His Leu Glu Arg Gly Val Leu Leu His Ser Ser Arg 
65                  70                  75                  80  


Gln Gly Val Phe Val Lys Arg Leu Cys Gln Gly Arg Val Phe Cys Ser 
                85                  90                  95      


Gly Asn Ala Val Val Cys Lys Gly Arg Pro Asn Lys Leu Glu Arg Asp 
            100                 105                 110         


Glu Val Val Gln Val Phe Asp Thr Ser Gln Phe Phe Arg Glu Leu Gln 
        115                 120                 125             


Gln Phe Tyr Asn Ser Gln Gly Arg Leu Pro Asp Gly Arg Val Val Leu 
    130                 135                 140                 


Cys Phe Gly Glu Glu Phe Pro Asp Met Ala Pro Leu Arg Ser Lys Leu 
145                 150                 155                 160 


Ile Leu Val Gln Ile Glu Gln Leu Tyr Val Arg Gln Leu Ala Glu Glu 
                165                 170                 175     


Ala Gly Lys Ser Cys Gly Ala Gly Ser Val Met Gln Ala Pro Glu Glu 
            180                 185                 190         


Pro Pro Pro Asp Gln Val Phe Arg Met Phe Pro Asp Ile Cys Ala Ser 
        195                 200                 205             


His Gln Arg Ser Phe Phe Arg Glu Asn Gln Gln Ile 
    210                 215                 220 


<210>  251
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  251

Met Cys Asp Arg Asn Gly Gly Arg Arg Leu Arg Gln Trp Leu Ile Glu 
1               5                   10                  15      


Gln Ile Asp Ser Ser Met Tyr Pro Gly Leu Ile Trp Glu Asn Glu Glu 
            20                  25                  30          


Lys Ser Met Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln Asp 
        35                  40                  45          


<210>  252
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  252

Met Cys Asp Arg Asn Gly Gly Arg Arg Leu Arg Gln Trp Leu Ile Glu 
1               5                   10                  15      


Gln Ile Asp Ser Ser Met Tyr Pro Gly Leu Ile Trp Glu Asn Glu Glu 
            20                  25                  30          


Lys Ser Met Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln Asp Tyr 
        35                  40                  45              


Asn Gln Glu Val Asp Ala Ser Ile Phe Lys Ala Trp Ala Val Phe Lys 
    50                  55                  60                  


Gly Lys Phe Lys Glu Gly Asp Lys Ala Glu Pro Ala Thr Trp Lys Thr 
65                  70                  75                  80  


Arg Leu Arg Cys Ala Leu Asn Lys Ser Pro Asp Phe Glu Glu Val Thr 
                85                  90                  95      


Asp Arg Ser Gln Leu Asp Ile Ser Glu Pro Tyr Lys Val Tyr Arg Ile 
            100                 105                 110         


Val Pro Glu Glu Glu Gln Lys Cys Asn Tyr Pro Leu Trp Ala 
        115                 120                 125     


<210>  253
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  253

Met Gly Ser Gly Cys Arg Ile Glu Cys Ile Phe Phe Ser Glu Phe His 
1               5                   10                  15      


Pro Thr Leu Gly Pro Lys Ile Thr Tyr Gln Val Pro Glu Asp Phe Ile 
            20                  25                  30          


Ser Arg Glu Leu Phe Asp Thr Val Gln Val Tyr Ile Ile Thr Lys Pro 
        35                  40                  45              


Glu Leu Gln Asn Lys Leu Ile Thr Val Thr Ala Met Glu Lys Lys Leu 
    50                  55                  60                  


Ile Gly Cys Pro Val Cys Ile Glu His Lys Lys Tyr Ser Arg Asn Ala 
65                  70                  75                  80  


Leu Leu Phe Asn Leu Gly Phe Val Cys Asp Ala Gln Ala Lys Thr Cys 
                85                  90                  95      


Ala Leu Glu Pro Ile Val Lys Lys Leu Ala Gly Tyr Leu Thr Thr Leu 
            100                 105                 110         


Glu Leu Glu Ser Ser Phe Val Ser Met Glu Glu Ser Lys Gln Lys Leu 
        115                 120                 125             


Val Pro Ile Met Thr Ile Leu Leu Glu Glu Leu Asn Ala Ser Gly Arg 
    130                 135                 140                 


Cys Thr Leu Pro Ile Asp Glu Ser Asn Thr Ile His Leu Lys Val Ile 
145                 150                 155                 160 


Glu Gln Arg Pro Asp Pro Pro Val Ala Gln Glu Tyr Asp Val Pro Val 
                165                 170                 175     


Phe Thr Lys Asp Lys Glu Asp Phe Phe Asn Ser Gln Trp Asp Leu Thr 
            180                 185                 190         


Thr Gln Gln Ile Leu Pro Tyr Ile Asp Gly Phe Arg His Ile Gln Lys 
        195                 200                 205             


Ile Ser Ala Glu Ala Asp Val Glu Leu Asn Leu Val Arg Ile Ala Ile 
    210                 215                 220                 


Gln Asn Leu Leu Tyr Tyr Gly Val Val Thr Leu Val Ser Ile Leu Gln 
225                 230                 235                 240 


Tyr Ser Asn Val Tyr Cys Pro Thr Pro Lys Val Gln Asp Leu Val Asp 
                245                 250                 255     


Asp Lys Ser Leu Gln Glu Ala Cys Leu Ser Tyr Val Thr Lys Gln Gly 
            260                 265                 270         


His Lys Arg Ala Ser Leu Arg Asp Val Phe Gln Leu Tyr Cys Ser Leu 
        275                 280                 285             


Ser Pro Gly Thr Thr Val Arg Asp Leu Ile Gly Arg His Pro Gln Gln 
    290                 295                 300                 


Leu Gln His Val Asp Glu Arg Lys Leu Ile Gln Phe Gly Leu Met Lys 
305                 310                 315                 320 


Asn Leu Ile Arg Arg Leu Gln Lys Tyr Pro Val Arg Val Thr Arg Glu 
                325                 330                 335     


Glu Gln Ser His Pro Ala Arg Leu Tyr Thr Gly Cys His Ser Tyr Asp 
            340                 345                 350         


Glu Ile Cys Cys Lys Thr Gly Met Ser Tyr His Glu Leu Asp Glu Arg 
        355                 360                 365             


Leu Glu Asn Asp Pro Asn Ile Ile Ile Cys Trp Lys 
    370                 375                 380 


<210>  254
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  254

Met Gly Ser Gly Cys Arg Ile Glu Cys Ile Phe Phe Ser Glu Phe His 
1               5                   10                  15      


Pro Thr Leu Gly Pro Lys Ile Thr Tyr Gln Val Pro Glu Asp Phe Ile 
            20                  25                  30          


Ser Arg Glu Leu Phe Asp Thr Val Gln Val Tyr Ile Ile Thr Lys Pro 
        35                  40                  45              


Glu Leu Gln Asn Lys Leu Ile Thr Val 
    50                  55          


<210>  255
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  255

Met Gly Ser Gly Cys Arg Ile Glu Cys Ile Phe Phe Ser Glu Phe His 
1               5                   10                  15      


Pro Thr Leu Gly Pro Lys Ile Thr Tyr Gln Val Pro Glu Asp Phe Ile 
            20                  25                  30          


Ser Arg Glu Leu Phe Asp Thr Val Gln Val Tyr Ile Ile Thr Lys Pro 
        35                  40                  45              


Glu Leu Gln Asn Lys Leu Ile Thr Val Tyr Gly Lys Glu Ala Asp Arg 
    50                  55                  60                  


Leu Ser Cys Val His Arg Thr Gln Glu Val Gln Pro Gln Cys Ser Pro 
65                  70                  75                  80  


Leu Gln Pro Gly Leu Arg Val 
                85          


<210>  256
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  256

Met Gly Ser Gly Cys Arg Ile Glu Cys Ile Phe Phe Ser Glu Phe His 
1               5                   10                  15      


Pro Thr Leu Gly Pro Lys Ile Thr Tyr Gln Val Pro Glu Asp Phe Ile 
            20                  25                  30          


Ser Arg Glu Leu Phe Asp Thr Val Gln Val Tyr Ile Ile Thr Lys Pro 
        35                  40                  45              


Glu Leu Gln Asn Lys Leu Ile Thr Val Thr Ala Met Glu Lys Lys Leu 
    50                  55                  60                  


Ile Gly Cys Pro Val Cys Ile Glu His Lys Lys Tyr Ser Arg Asn Ala 
65                  70                  75                  80  


Leu Leu Phe Asn Leu Gly Phe Val Cys Asp Ala Gln Ala Lys Thr Cys 
                85                  90                  95      


Ala Leu Glu Pro Ile Val Lys Lys Leu Ala Gly Tyr Leu Thr Thr Leu 
            100                 105                 110         


Glu Arg Ala Ala Ser Cys Pro Trp Arg Arg Ala Ser Arg Ser Trp Cys 
        115                 120                 125             


Pro Ser 
    130 


<210>  257
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  257

Met Gln Lys Tyr Glu Lys Leu Glu Lys Ile Gly Glu Gly Thr Tyr Gly 
1               5                   10                  15      


Thr Val Phe Lys Ala Lys Asn Arg Glu Thr His Glu Ile Val Ala Leu 
            20                  25                  30          


Lys Arg Val Arg Leu Asp Asp Asp Asp Glu Gly Val Pro Ser Ser Ala 
        35                  40                  45              


Leu Arg Glu Ile Cys Leu Leu Lys Glu Leu Lys His Lys Asn Ile Val 
    50                  55                  60                  


Arg Leu His Asp Val Leu His Ser Asp Lys Lys Leu Thr Leu Val Phe 
65                  70                  75                  80  


Glu Phe Cys Asp Gln Asp Leu Lys Lys Tyr Phe Asp Ser Cys Asn Gly 
                85                  90                  95      


Asp Leu Asp Pro Glu Ile Val Lys Asn Gly Glu Leu Lys Leu Ala Asp 
            100                 105                 110         


Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Val Arg Cys Tyr Ser Ala 
        115                 120                 125             


Glu Val Val Thr Leu Trp Tyr Arg Pro Pro Asp Val Leu Phe Gly Ala 
    130                 135                 140                 


Lys Leu Tyr Ser Thr Ser Ile Asp Met Trp Ser Ala Gly Cys Ile Phe 
145                 150                 155                 160 


Ala Glu Leu Ala Asn Ala Gly Arg Pro Leu Phe Pro Gly Asn Asp Val 
                165                 170                 175     


Asp Asp Gln Leu Lys Arg Ile Phe Arg Leu Leu Gly Thr Pro Thr Glu 
            180                 185                 190         


Glu Gln Trp Pro Ser Met Thr Lys Leu Pro Asp Tyr Lys Pro Tyr Pro 
        195                 200                 205             


Met Tyr Pro Ala Thr Thr Ser Leu Val Asn Val Val Pro Lys Leu Asn 
    210                 215                 220                 


Ala Thr Gly Arg Asp Leu Leu Gln Asn Leu Leu Lys Cys Asn Pro Val 
225                 230                 235                 240 


Gln Arg Ile Ser Ala Glu Glu Ala Leu Gln His Pro Tyr Phe Ser Asp 
                245                 250                 255     


Phe Cys Pro Pro 
            260 


<210>  258
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  258

Met Gln Lys Tyr Glu Lys Leu Glu Lys Ile Gly Glu Gly Thr Tyr Gly 
1               5                   10                  15      


Thr Val Phe Lys Ala Lys Asn Arg Glu Thr His Glu Ile Val Ala Leu 
            20                  25                  30          


Lys Arg Val Arg Leu Asp Asp Asp Asp Glu Gly Val Pro Ser Ser Ala 
        35                  40                  45              


Leu Arg Glu Ile Cys Leu Leu Lys Glu Leu Lys His Lys Asn Ile Val 
    50                  55                  60                  


Arg Leu His Asp Val Leu His Ser Asp Lys Lys Leu Thr Leu Val Phe 
65                  70                  75                  80  


Glu Phe Cys Asp Gln Asp Leu Lys Lys Tyr Phe Asp Ser Cys Asn Gly 
                85                  90                  95      


Asp Leu Asp Pro Glu Ile Val Lys Ser Phe Leu Phe Gln Leu Leu Lys 
            100                 105                 110         


Gly Leu Gly Phe Cys His Ser Arg Asn Val Leu His Arg Asp Leu Lys 
        115                 120                 125             


Pro Gln Asn Leu Leu Ile Asn Arg Asn Gly Glu Leu Lys Leu Ala Asp 
    130                 135                 140                 


Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Val Arg Cys Tyr Ser Ala 
145                 150                 155                 160 


Glu Val Val Thr Leu Trp Tyr Arg Pro Pro Asp Val Leu Phe Gly Ala 
                165                 170                 175     


Lys Leu Tyr Ser Thr Ser Ile Asp Met Trp Ser Ala Gly Cys Ile Phe 
            180                 185                 190         


Ala Glu Leu Ala Asn Ala Gly Arg Pro Leu Phe Pro Gly Asn Asp Val 
        195                 200                 205             


Asp Asp Gln Leu Lys Arg Ile Phe Arg Leu Leu Gly Thr Pro Thr Glu 
    210                 215                 220                 


Glu Gln Trp Pro Ser Met Thr Lys Leu Pro Asp Tyr Lys Pro Tyr Pro 
225                 230                 235                 240 


Met Tyr Pro Ala Thr Thr Ser Leu Val Asn Val Val Pro Lys Leu Asn 
                245                 250                 255     


Ala Thr Gly Arg Asp Leu Leu Gln Asn Leu Leu Lys Cys Asn Pro Val 
            260                 265                 270         


Gln Arg Ile Ser Ala Glu Glu Ala Leu Gln His Pro Tyr Phe Ser Asp 
        275                 280                 285             


Phe Cys Pro Pro 
    290         


<210>  259
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  259

Met Ser Gly Pro Cys Gly Glu Lys Pro Val Leu Glu Ala Ser Pro Thr 
1               5                   10                  15      


Met Ser Leu Trp Glu Phe Glu Asp Ser His Ser Arg Gln Gly Thr Pro 
            20                  25                  30          


Arg Pro Gly Gln Glu Leu Ala Ala Glu Glu Ala Ser Ala Leu Glu Leu 
        35                  40                  45              


Gln Met Lys Val Asp Phe Phe Arg Lys Leu Gly Tyr Ser Ser Thr Glu 
    50                  55                  60                  


Ile His Ser Val Leu Gln Lys Leu Gly Val Gln Ala Asp Thr Asn Thr 
65                  70                  75                  80  


Val Leu Gly Glu Leu Val Lys His Gly Thr Ala Thr Glu Arg Glu Arg 
                85                  90                  95      


Gln Thr Ser Pro Asp Pro Cys Pro Gln Leu Pro Leu Val Pro Arg Gly 
            100                 105                 110         


Gly Gly Thr Pro Lys Ala Pro Asn Leu Glu Pro Pro Leu Pro Glu Glu 
        115                 120                 125             


Glu Lys Glu Gly Ser Asp Leu Arg Pro Val Val Ile Asp Gly Ser Asn 
    130                 135                 140                 


Val Ala Met Ser His Gly Asn Lys Glu Val Phe Ser Cys Arg Gly Ile 
145                 150                 155                 160 


Leu Leu Ala Val Asn Trp Phe Leu Glu Arg Gly His Thr Asp Ile Thr 
                165                 170                 175     


Val Phe Val Pro Ser Trp Arg Lys Glu Gln Pro Arg Pro Asp Val Pro 
            180                 185                 190         


Ile Thr Asp Gln His Ile Leu Arg Glu Leu Glu Lys Lys Lys Ile Leu 
        195                 200                 205             


Val Phe Thr Pro Ser Arg Arg Val Gly Gly Lys Arg Val Val Cys Tyr 
    210                 215                 220                 


Asp Asp Arg Phe Ile Val Lys Leu Ala Tyr Glu Ser Asp Gly Ile Val 
225                 230                 235                 240 


Val Ser Asn Asp Thr Tyr Arg Asp Leu Gln Gly Glu Arg Gln Glu Trp 
                245                 250                 255     


Lys Arg Phe Ile Glu Glu Arg Leu Leu Met Tyr Ser Phe Val Asn Asp 
            260                 265                 270         


Lys Phe Met Pro Pro Asp Asp Pro Leu Gly Arg His Gly Pro Ser Leu 
        275                 280                 285             


Asp Asn Phe Leu Arg Lys Lys Pro Leu Thr Leu Glu His Arg Lys Gln 
    290                 295                 300                 


Pro Cys Pro Tyr Gly Arg Lys Cys Thr Tyr Gly Ile Lys Cys Arg Phe 
305                 310                 315                 320 


Phe His Pro Glu Arg Pro Ser Cys Pro Gln Arg Ser Val Ala Asp Glu 
                325                 330                 335     


Leu Arg Ala Asn Ala Leu Leu Ser Pro Pro Arg Ala Pro Ser Lys Asp 
            340                 345                 350         


Lys Asn Gly Arg Arg Pro Ser Pro Ser Ser Gln Ser Ser Ser Leu Leu 
        355                 360                 365             


Thr Glu Ser Glu Gln Cys Ser Leu Asp Gly Lys Lys Leu Gly Ala Gln 
    370                 375                 380                 


Ala Ser Pro Gly Ser Arg Gln Glu Gly Leu Thr Gln Thr Tyr Ala Pro 
385                 390                 395                 400 


Ser Gly Arg Ser Leu Ala Pro Ser Gly Gly Ser Gly Ser Ser Phe Gly 
                405                 410                 415     


Pro Thr Asp Trp Leu Pro Gln Thr Leu Asp Ser Leu Pro Tyr Val Ser 
            420                 425                 430         


Gln Asp Cys Leu Asp Ser Gly Ile Gly Ser Leu Glu Ser Gln Met Ser 
        435                 440                 445             


Glu Leu Trp Gly Val Arg Gly Gly Gly Pro Gly Glu Pro Gly Pro Pro 
    450                 455                 460                 


Arg Ala Pro Tyr Thr Gly Tyr Ser Pro Tyr Gly Ser Glu Leu Pro Ala 
465                 470                 475                 480 


Thr Ala Ala Phe Ser Ala Phe Gly Arg Ala Met Gly Ala Gly His Phe 
                485                 490                 495     


Ser Val Pro Ala Asp Tyr Pro Pro Ala Pro Pro Ala Phe Pro Pro Arg 
            500                 505                 510         


Glu Tyr Trp Ser Glu Pro Tyr Pro Leu Pro Pro Pro Thr Ser Val Leu 
        515                 520                 525             


Gln Glu Pro Pro Val Gln Ser Pro Gly Ala Gly Arg Ser Pro Trp Gly 
    530                 535                 540                 


Arg Ala Gly Ser Leu Ala Lys Glu Gln Ala Ser Val Tyr Thr Lys Leu 
545                 550                 555                 560 


Cys Gly Val Phe Pro Pro His Leu Val Glu Ala Val Met Gly Arg Phe 
                565                 570                 575     


Pro Gln Leu Leu Asp Pro Gln Gln Leu Ala Ala Glu Ile Leu Ser Tyr 
            580                 585                 590         


Lys Ser Gln His Pro Ser Glu 
        595                 


<210>  260
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  260

Asp Asp Arg Phe Ile Val Lys Leu Ala Tyr Glu Ser Asp Gly Ile Val 
1               5                   10                  15      


Val Ser Asn Asp Thr Tyr Arg Asp Leu Gln Gly Glu Arg Gln Glu Trp 
            20                  25                  30          


Lys Arg Phe Ile Glu Glu Arg Leu Leu Met Tyr Ser Phe Val Asn Asp 
        35                  40                  45              


Lys Leu Ala Ile Gly Pro Phe Ser Ala Ile Arg Ser Pro Cys Met Ala 
    50                  55                  60                  


Pro Thr Ser Arg Glu Phe Phe Ala Pro Ser Ala Gly Leu Cys Pro Leu 
65                  70                  75                  80  


Met Thr His Trp Ala Gly Thr Gly Pro Ala Trp Thr Thr Ser Cys Val 
                85                  90                  95      


Arg Ser His Ser Leu Trp Ser Thr Gly Ser Ser Arg Val Pro Met Val 
            100                 105                 110         


Trp Asn Pro Ala Cys Pro Pro Arg Pro Ser Ser Leu Leu Pro Phe Leu 
        115                 120                 125             


Ser Pro Val 
    130     


<210>  261
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  261

Met Ser Gly Pro Cys Gly Glu Lys Pro Val Leu Glu Ala Ser Pro Thr 
1               5                   10                  15      


Met Ser Leu Trp Glu Phe Glu Asp Ser His Ser Arg Gln Gly Thr Pro 
            20                  25                  30          


Arg Pro Gly Gln Glu Leu Ala Ala Glu Glu Ala Ser Ala Leu Glu Leu 
        35                  40                  45              


Gln Met Lys Val Asp Phe Phe Arg Lys Leu Gly Tyr Ser Ser Thr Glu 
    50                  55                  60                  


Ile His Ser Val Leu Gln Lys Leu Gly Val Gln Ala Asp Thr Asn Thr 
65                  70                  75                  80  


Val Leu Gly Glu Leu Val Lys His Gly Thr Ala Thr Glu Arg Glu Arg 
                85                  90                  95      


Gln Thr Ser Pro Asp Pro Cys Pro Gln Leu Pro Leu Val Pro Arg Gly 
            100                 105                 110         


Gly Gly Thr Pro Lys Ala Pro Asn Leu Glu Pro Pro Leu Pro Glu Glu 
        115                 120                 125             


Glu Lys Glu Gly Ser Asp Leu Arg Pro Val Val Ile Asp Gly Ser Asn 
    130                 135                 140                 


Val Ala Met Ser His Gly Asn Lys Glu Val Phe Ser Cys Arg Gly Ile 
145                 150                 155                 160 


Leu Leu Ala Val Asn Trp Phe Leu Glu Arg Gly His Thr Asp Ile Thr 
                165                 170                 175     


Val Phe Val Pro Ser Trp Arg Lys Glu Gln Pro Arg Pro Asp Val Pro 
            180                 185                 190         


Ile Thr Asp Gln His Ile Leu Arg Glu Leu Glu Lys Lys Lys Ile Leu 
        195                 200                 205             


Val Phe Thr Pro Ser Arg Arg Val Gly Gly Lys Arg Val Val Cys Tyr 
    210                 215                 220                 


Asp Asp Arg Phe Ile Val Lys Leu Ala Tyr Glu Ser Asp Gly Ile Val 
225                 230                 235                 240 


Val Ser Asn Asp Thr Tyr Arg Asp Leu Gln Gly Glu Arg Gln Glu Trp 
                245                 250                 255     


Lys Arg Phe Ile Glu Glu Arg Leu Leu Met Tyr Ser Phe Val Asn Asp 
            260                 265                 270         


Asn Lys Ala Cys His Arg Pro Leu Leu Ser Asn 
        275                 280             


<210>  262
<211>  1560
<212>  PRT
<213>  Homo sapiens

<400>  262

Met Asp Asp Glu Asp Gly Arg Cys Leu Leu Asp Val Ile Cys Asp Pro 
1               5                   10                  15      


Gln Ala Leu Asn Asp Phe Leu His Gly Ser Glu Lys Leu Asp Ser Asp 
            20                  25                  30          


Asp Leu Leu Asp Asn Pro Gly Glu Ala Gln Ser Ala Phe Tyr Glu Gly 
        35                  40                  45              


Pro Gly Leu His Val Gln Glu Ala Ser Gly Asn His Leu Asn Pro Glu 
    50                  55                  60                  


Pro Asn Gln Pro Ala Pro Ser Val Asp Leu Asp Phe Leu Glu Asp Asp 
65                  70                  75                  80  


Ile Leu Gly Ser Pro Ala Thr Gly Gly Gly Gly Gly Gly Ser Gly Gly 
                85                  90                  95      


Ala Asp Gln Pro Cys Asp Ile Leu Gln Gln Ser Leu Gln Glu Ala Asn 
            100                 105                 110         


Ile Thr Glu Gln Thr Leu Glu Ala Glu Ala Glu Leu Asp Leu Gly Pro 
        115                 120                 125             


Phe Gln Leu Pro Thr Leu Gln Pro Ala Asp Gly Gly Ala Gly Pro Thr 
    130                 135                 140                 


Gly Ala Gly Gly Ala Ala Ala Val Ala Ala Gly Pro Gln Ala Leu Phe 
145                 150                 155                 160 


Pro Gly Ser Thr Asp Leu Leu Gly Leu Gln Gly Pro Pro Thr Val Leu 
                165                 170                 175     


Thr His Gln Ala Leu Val Pro Pro Gln Asp Val Val Asn Lys Ala Leu 
            180                 185                 190         


Ser Val Gln Pro Phe Leu Gln Pro Val Gly Leu Gly Asn Val Thr Leu 
        195                 200                 205             


Gln Pro Ile Pro Gly Leu Gln Gly Leu Pro Asn Gly Ser Pro Gly Gly 
    210                 215                 220                 


Ala Thr Ala Ala Thr Leu Gly Leu Ala Pro Ile Gln Val Val Gly Gln 
225                 230                 235                 240 


Pro Val Met Ala Leu Asn Thr Pro Thr Ser Gln Leu Leu Ala Lys Gln 
                245                 250                 255     


Val Pro Val Ser Gly Tyr Leu Ala Ser Ala Ala Gly Pro Ser Glu Pro 
            260                 265                 270         


Val Thr Leu Ala Ser Ala Gly Val Ser Pro Gln Gly Ala Gly Leu Val 
        275                 280                 285             


Ile Gln Lys Asn Leu Ser Ala Ala Val Ala Thr Thr Leu Asn Gly Asn 
    290                 295                 300                 


Ser Val Phe Gly Gly Ala Gly Ala Ala Ser Ala Pro Thr Gly Thr Pro 
305                 310                 315                 320 


Ser Gly Gln Pro Leu Ala Val Ala Pro Gly Leu Gly Ser Ser Pro Leu 
                325                 330                 335     


Val Pro Ala Pro Asn Val Ile Leu His Arg Thr Pro Thr Pro Ile Gln 
            340                 345                 350         


Pro Lys Pro Ala Gly Val Leu Pro Pro Lys Leu Tyr Gln Leu Thr Pro 
        355                 360                 365             


Lys Pro Phe Ala Pro Ala Gly Ala Thr Leu Thr Ile Gln Gly Glu Pro 
    370                 375                 380                 


Gly Ala Leu Pro Gln Gln Pro Lys Ala Pro Gln Asn Leu Thr Phe Met 
385                 390                 395                 400 


Ala Ala Gly Lys Ala Gly Gln Asn Val Val Leu Ser Gly Phe Pro Ala 
                405                 410                 415     


Pro Ala Leu Gln Ala Asn Val Phe Lys Gln Pro Pro Ala Thr Thr Thr 
            420                 425                 430         


Gly Ala Ala Pro Pro Gln Pro Pro Gly Ala Leu Ser Lys Pro Met Ser 
        435                 440                 445             


Val His Leu Leu Asn Gln Gly Ser Ser Ile Val Ile Pro Ala Gln His 
    450                 455                 460                 


Met Leu Pro Gly Gln Asn Gln Phe Leu Leu Pro Gly Ala Pro Ala Val 
465                 470                 475                 480 


Gln Leu Pro Gln Gln Leu Ser Ala Leu Pro Ala Asn Val Gly Gly Gln 
                485                 490                 495     


Ile Leu Ala Ala Ala Ala Pro His Thr Gly Gly Gln Leu Ile Ala Asn 
            500                 505                 510         


Pro Ile Leu Thr Asn Gln Asn Leu Ala Gly Pro Leu Ser Leu Gly Pro 
        515                 520                 525             


Val Leu Ala Pro His Ser Gly Ala His Ser Ala His Ile Leu Ser Ala 
    530                 535                 540                 


Ala Pro Ile Gln Val Gly Gln Pro Ala Leu Phe Gln Met Pro Val Ser 
545                 550                 555                 560 


Leu Ala Ala Gly Ser Leu Pro Thr Gln Ser Gln Pro Ala Pro Ala Gly 
                565                 570                 575     


Pro Ala Ala Thr Thr Val Leu Gln Gly Val Thr Leu Pro Pro Ser Ala 
            580                 585                 590         


Val Ala Met Leu Asn Thr Pro Asp Gly Leu Val Gln Pro Ala Thr Pro 
        595                 600                 605             


Ala Ala Ala Thr Gly Glu Ala Ala Pro Val Leu Thr Val Gln Pro Ala 
    610                 615                 620                 


Pro Gln Ala Pro Pro Ala Val Ser Thr Pro Leu Pro Leu Gly Leu Gln 
625                 630                 635                 640 


Gln Pro Gln Ala Gln Gln Pro Pro Gln Ala Pro Thr Pro Gln Ala Ala 
                645                 650                 655     


Ala Pro Pro Gln Ala Thr Thr Pro Gln Pro Ser Pro Gly Leu Ala Ser 
            660                 665                 670         


Ser Pro Glu Lys Ile Val Leu Gly Gln Pro Pro Ser Ala Thr Pro Thr 
        675                 680                 685             


Ala Ile Leu Thr Gln Asp Ser Leu Gln Met Phe Leu Pro Gln Glu Arg 
    690                 695                 700                 


Ser Gln Gln Pro Leu Ser Ala Glu Gly Pro His Leu Ser Val Pro Ala 
705                 710                 715                 720 


Ser Val Ile Val Ser Ala Pro Pro Pro Ala Gln Asp Pro Ala Pro Ala 
                725                 730                 735     


Thr Pro Val Ala Lys Gly Ala Gly Leu Gly Pro Gln Ala Pro Asp Ser 
            740                 745                 750         


Gln Ala Ser Pro Ala Pro Ala Pro Gln Ile Pro Ala Ala Ala Pro Leu 
        755                 760                 765             


Lys Gly Pro Gly Pro Ser Ser Ser Pro Ser Leu Pro His Gln Ala Pro 
    770                 775                 780                 


Leu Gly Asp Ser Pro His Leu Pro Ser Pro His Pro Thr Arg Pro Pro 
785                 790                 795                 800 


Ser Arg Pro Pro Ser Arg Pro Gln Ser Val Ser Arg Pro Pro Ser Glu 
                805                 810                 815     


Pro Pro Leu His Pro Cys Pro Pro Pro Gln Ala Pro Pro Thr Leu Pro 
            820                 825                 830         


Gly Ile Phe Val Ile Gln Asn Gln Leu Gly Val Pro Pro Pro Ala Ser 
        835                 840                 845             


Asn Pro Ala Pro Thr Ala Pro Gly Pro Pro Gln Pro Pro Leu Arg Pro 
    850                 855                 860                 


Gln Ser Gln Pro Pro Glu Gly Pro Leu Pro Pro Ala Pro His Leu Pro 
865                 870                 875                 880 


Pro Ser Ser Thr Ser Ser Ala Val Ala Ser Ser Ser Glu Thr Ser Ser 
                885                 890                 895     


Arg Leu Pro Ala Pro Thr Pro Ser Asp Phe Gln Leu Gln Phe Pro Pro 
            900                 905                 910         


Ser Gln Gly Pro His Lys Ser Pro Thr Pro Pro Pro Thr Leu His Leu 
        915                 920                 925             


Val Pro Glu Pro Ala Ala Pro Pro Pro Pro Pro Pro Arg Thr Phe Gln 
    930                 935                 940                 


Met Val Thr Thr Pro Phe Pro Ala Leu Pro Gln Pro Lys Ala Leu Leu 
945                 950                 955                 960 


Glu Arg Phe His Gln Val Pro Ser Gly Ile Ile Leu Gln Asn Lys Ala 
                965                 970                 975     


Gly Gly Ala Pro Ala Ala Pro Gln Thr Ser Thr Ser Leu Gly Pro Leu 
            980                 985                 990         


Thr Ser Pro Ala Ala Ser Val Leu  Val Ser Gly Gln Ala  Pro Ser Gly 
        995                 1000                 1005             


Thr Pro  Thr Ala Pro Ser His  Ala Pro Ala Pro Ala  Pro Met Ala 
    1010                 1015                 1020             


Ala Thr  Gly Leu Pro Pro Leu  Leu Pro Ala Glu Asn  Lys Ala Phe 
    1025                 1030                 1035             


Ala Ser  Asn Leu Pro Thr Leu  Asn Val Ala Lys Ala  Ala Ser Ser 
    1040                 1045                 1050             


Gly Pro  Gly Lys Pro Ser Gly  Leu Gln Tyr Glu Ser  Lys Leu Ser 
    1055                 1060                 1065             


Gly Leu  Lys Lys Pro Pro Thr  Leu Gln Pro Ser Lys  Glu Ala Cys 
    1070                 1075                 1080             


Phe Leu  Glu His Leu His Lys  His Gln Gly Ser Val  Leu His Pro 
    1085                 1090                 1095             


Asp Tyr  Lys Thr Ala Phe Pro  Ser Phe Glu Asp Ala  Leu His Arg 
    1100                 1105                 1110             


Leu Leu  Pro Tyr His Val Tyr  Gln Gly Ala Leu Pro  Ser Pro Ser 
    1115                 1120                 1125             


Asp Tyr  His Lys Val Asp Glu  Glu Phe Glu Thr Val  Ser Thr Gln 
    1130                 1135                 1140             


Leu Leu  Lys Arg Thr Gln Ala  Met Leu Asn Lys Tyr  Arg Leu Leu 
    1145                 1150                 1155             


Leu Leu  Glu Glu Ser Arg Arg  Val Ser Pro Ser Ala  Glu Met Val 
    1160                 1165                 1170             


Met Ile  Asp Arg Met Phe Ile  Gln Glu Glu Lys Thr  Thr Leu Ala 
    1175                 1180                 1185             


Leu Asp  Lys Gln Leu Ala Lys  Glu Lys Pro Asp Glu  Tyr Val Ser 
    1190                 1195                 1200             


Ser Ser  Arg Ser Leu Gly Leu  Pro Ile Ala Ala Ser  Ser Glu Gly 
    1205                 1210                 1215             


His Arg  Leu Pro Gly His Gly  Pro Leu Ser Ser Ser  Ala Pro Gly 
    1220                 1225                 1230             


Ala Ser  Thr Gln Pro Pro Pro  His Leu Pro Thr Lys  Leu Val Ile 
    1235                 1240                 1245             


Arg His  Gly Gly Ala Gly Gly  Ser Pro Ser Val Thr  Trp Ala Arg 
    1250                 1255                 1260             


Ala Ser  Ser Ser Leu Ser Ser  Ser Ser Ser Ser Ser  Ser Ala Ala 
    1265                 1270                 1275             


Ser Ser  Leu Asp Ala Asp Glu  Asp Gly Pro Met Pro  Ser Arg Asn 
    1280                 1285                 1290             


Arg Pro  Pro Ile Lys Thr Tyr  Glu Ala Arg Ser Arg  Ile Gly Leu 
    1295                 1300                 1305             


Lys Leu  Lys Ile Lys Gln Glu  Ala Gly Leu Ser Lys  Val Val His 
    1310                 1315                 1320             


Asn Thr  Ala Leu Asp Pro Val  His Gln Pro Pro Pro  Pro Pro Ala 
    1325                 1330                 1335             


Thr Leu  Lys Val Ala Glu Pro  Pro Pro Arg Pro Pro  Pro Pro Pro 
    1340                 1345                 1350             


Pro Pro  Thr Gly Gln Met Asn  Gly Thr Val Asp His  Pro Pro Pro 
    1355                 1360                 1365             


Ala Ala  Pro Glu Arg Lys Pro  Leu Gly Thr Ala Pro  His Cys Pro 
    1370                 1375                 1380             


Arg Leu  Pro Leu Arg Lys Thr  Tyr Arg Glu Asn Val  Gly Gly Pro 
    1385                 1390                 1395             


Gly Ala  Pro Glu Gly Thr Pro  Ala Gly Arg Ala Arg  Gly Gly Ser 
    1400                 1405                 1410             


Pro Ala  Pro Leu Pro Ala Lys  Val Asp Glu Ala Thr  Ser Gly Leu 
    1415                 1420                 1425             


Ile Arg  Glu Leu Ala Ala Val  Glu Asp Glu Leu Tyr  Gln Arg Met 
    1430                 1435                 1440             


Leu Lys  Gly Pro Pro Pro Glu  Pro Ala Ala Ser Ala  Ala Gln Gly 
    1445                 1450                 1455             


Thr Gly  Asp Pro Asp Trp Glu  Ala Pro Gly Leu Pro  Pro Ala Lys 
    1460                 1465                 1470             


Arg Arg  Lys Ser Glu Ser Pro  Asp Val Asp Gln Ala  Ser Phe Ser 
    1475                 1480                 1485             


Ser Asp  Ser Pro Gln Asp Asp  Thr Leu Thr Glu His  Leu Gln Ser 
    1490                 1495                 1500             


Ala Ile  Asp Ser Ile Leu Asn  Leu Gln Gln Ala Pro  Gly Arg Thr 
    1505                 1510                 1515             


Pro Ala  Pro Ser Tyr Pro His  Ala Ala Ser Ala Gly  Thr Pro Ala 
    1520                 1525                 1530             


Ser Pro  Pro Pro Leu His Arg  Pro Glu Ala Tyr Pro  Pro Ser Ser 
    1535                 1540                 1545             


His Asn  Gly Gly Leu Gly Ala  Arg Thr Leu Thr Arg  
    1550                 1555                 1560 


<210>  263
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  263

Met Asp Asp Glu Asp Gly Arg Cys Leu Leu Asp Val Ile Cys Asp Pro 
1               5                   10                  15      


Gln Ala Leu Asn Asp Phe Leu His Gly Ser Glu Lys Leu Asp Ser Asp 
            20                  25                  30          


Asp Leu Leu Asp Asn Pro Gly Glu Ala Gln Ser Ala Phe Tyr Glu Gly 
        35                  40                  45              


Pro Gly Leu His Val Gln Glu Ala Ser Gly Asn His Leu Asn Pro Glu 
    50                  55                  60                  


Pro Asn Gln Pro Ala Pro Ser Val Asp Leu Asp Phe Leu Glu Asp Asp 
65                  70                  75                  80  


Ile Leu Gly Ser Pro Ala Thr Gly Gly Gly Gly Gly Gly Ser Gly Gly 
                85                  90                  95      


Ala Asp Gln Pro Cys Asp Ile Leu Gln Gln Ser Leu Gln Glu Ala Asn 
            100                 105                 110         


Ile Thr Glu Gln Thr Leu Glu Ala Glu Ala Glu Leu Asp Leu 
        115                 120                 125     


<210>  264
<211>  1318
<212>  PRT
<213>  Homo sapiens

<400>  264

Met Ala Leu Asn Thr Pro Thr Ser Gln Leu Leu Ala Lys Gln Val Pro 
1               5                   10                  15      


Val Ser Gly Tyr Leu Ala Ser Ala Ala Gly Pro Ser Glu Pro Val Thr 
            20                  25                  30          


Leu Ala Ser Ala Gly Val Ser Pro Gln Gly Ala Gly Leu Val Ile Gln 
        35                  40                  45              


Lys Asn Leu Ser Ala Ala Val Ala Thr Thr Leu Asn Gly Asn Ser Val 
    50                  55                  60                  


Phe Gly Gly Ala Gly Ala Ala Ser Ala Pro Thr Gly Thr Pro Ser Gly 
65                  70                  75                  80  


Gln Pro Leu Ala Val Ala Pro Gly Leu Gly Ser Ser Pro Leu Val Pro 
                85                  90                  95      


Ala Pro Asn Val Ile Leu His Arg Thr Pro Thr Pro Ile Gln Pro Lys 
            100                 105                 110         


Pro Ala Gly Val Leu Pro Pro Lys Leu Tyr Gln Leu Thr Pro Lys Pro 
        115                 120                 125             


Phe Ala Pro Ala Gly Ala Thr Leu Thr Ile Gln Gly Glu Pro Gly Ala 
    130                 135                 140                 


Leu Pro Gln Gln Pro Lys Ala Pro Gln Asn Leu Thr Phe Met Ala Ala 
145                 150                 155                 160 


Gly Lys Ala Gly Gln Asn Val Val Leu Ser Gly Phe Pro Ala Pro Ala 
                165                 170                 175     


Leu Gln Ala Asn Val Phe Lys Gln Pro Pro Ala Thr Thr Thr Gly Ala 
            180                 185                 190         


Ala Pro Pro Gln Pro Pro Gly Ala Leu Ser Lys Pro Met Ser Val His 
        195                 200                 205             


Leu Leu Asn Gln Gly Ser Ser Ile Val Ile Pro Ala Gln His Met Leu 
    210                 215                 220                 


Pro Gly Gln Asn Gln Phe Leu Leu Pro Gly Ala Pro Ala Val Gln Leu 
225                 230                 235                 240 


Pro Gln Gln Leu Ser Ala Leu Pro Ala Asn Val Gly Gly Gln Ile Leu 
                245                 250                 255     


Ala Ala Ala Ala Pro His Thr Gly Gly Gln Leu Ile Ala Asn Pro Ile 
            260                 265                 270         


Leu Thr Asn Gln Asn Leu Ala Gly Pro Leu Ser Leu Gly Pro Val Leu 
        275                 280                 285             


Ala Pro His Ser Gly Ala His Ser Ala His Ile Leu Ser Ala Ala Pro 
    290                 295                 300                 


Ile Gln Val Gly Gln Pro Ala Leu Phe Gln Met Pro Val Ser Leu Ala 
305                 310                 315                 320 


Ala Gly Ser Leu Pro Thr Gln Ser Gln Pro Ala Pro Ala Gly Pro Ala 
                325                 330                 335     


Ala Thr Thr Val Leu Gln Gly Val Thr Leu Pro Pro Ser Ala Val Ala 
            340                 345                 350         


Met Leu Asn Thr Pro Asp Gly Leu Val Gln Pro Ala Thr Pro Ala Ala 
        355                 360                 365             


Ala Thr Gly Glu Ala Ala Pro Val Leu Thr Val Gln Pro Ala Pro Gln 
    370                 375                 380                 


Ala Pro Pro Ala Val Ser Thr Pro Leu Pro Leu Gly Leu Gln Gln Pro 
385                 390                 395                 400 


Gln Ala Gln Gln Pro Pro Gln Ala Pro Thr Pro Gln Ala Ala Ala Pro 
                405                 410                 415     


Pro Gln Ala Thr Thr Pro Gln Pro Ser Pro Gly Leu Ala Ser Ser Pro 
            420                 425                 430         


Glu Lys Ile Val Leu Gly Gln Pro Pro Ser Ala Thr Pro Thr Ala Ile 
        435                 440                 445             


Leu Thr Gln Asp Ser Leu Gln Met Phe Leu Pro Gln Glu Arg Ser Gln 
    450                 455                 460                 


Gln Pro Leu Ser Ala Glu Gly Pro His Leu Ser Val Pro Ala Ser Val 
465                 470                 475                 480 


Ile Val Ser Ala Pro Pro Pro Ala Gln Asp Pro Ala Pro Ala Thr Pro 
                485                 490                 495     


Val Ala Lys Gly Ala Gly Leu Gly Pro Gln Ala Pro Asp Ser Gln Ala 
            500                 505                 510         


Ser Pro Ala Pro Ala Pro Gln Ile Pro Ala Ala Ala Pro Leu Lys Gly 
        515                 520                 525             


Pro Gly Pro Ser Ser Ser Pro Ser Leu Pro His Gln Ala Pro Leu Gly 
    530                 535                 540                 


Asp Ser Pro His Leu Pro Ser Pro His Pro Thr Arg Pro Pro Ser Arg 
545                 550                 555                 560 


Pro Pro Ser Arg Pro Gln Ser Val Ser Arg Pro Pro Ser Glu Pro Pro 
                565                 570                 575     


Leu His Pro Cys Pro Pro Pro Gln Ala Pro Pro Thr Leu Pro Gly Ile 
            580                 585                 590         


Phe Val Ile Gln Asn Gln Leu Gly Val Pro Pro Pro Ala Ser Asn Pro 
        595                 600                 605             


Ala Pro Thr Ala Pro Gly Pro Pro Gln Pro Pro Leu Arg Pro Gln Ser 
    610                 615                 620                 


Gln Pro Pro Glu Gly Pro Leu Pro Pro Ala Pro His Leu Pro Pro Ser 
625                 630                 635                 640 


Ser Thr Ser Ser Ala Val Ala Ser Ser Ser Glu Thr Ser Ser Arg Leu 
                645                 650                 655     


Pro Ala Pro Thr Pro Ser Asp Phe Gln Leu Gln Phe Pro Pro Ser Gln 
            660                 665                 670         


Gly Pro His Lys Ser Pro Thr Pro Pro Pro Thr Leu His Leu Val Pro 
        675                 680                 685             


Glu Pro Ala Ala Pro Pro Pro Pro Pro Pro Arg Thr Phe Gln Met Val 
    690                 695                 700                 


Thr Thr Pro Phe Pro Ala Leu Pro Gln Pro Lys Ala Leu Leu Glu Arg 
705                 710                 715                 720 


Phe His Gln Val Pro Ser Gly Ile Ile Leu Gln Asn Lys Ala Gly Gly 
                725                 730                 735     


Ala Pro Ala Ala Pro Gln Thr Ser Thr Ser Leu Gly Pro Leu Thr Ser 
            740                 745                 750         


Pro Ala Ala Ser Val Leu Val Ser Gly Gln Ala Pro Ser Gly Thr Pro 
        755                 760                 765             


Thr Ala Pro Ser His Ala Pro Ala Pro Ala Pro Met Ala Ala Thr Gly 
    770                 775                 780                 


Leu Pro Pro Leu Leu Pro Ala Glu Asn Lys Ala Phe Ala Ser Asn Leu 
785                 790                 795                 800 


Pro Thr Leu Asn Val Ala Lys Ala Ala Ser Ser Gly Pro Gly Lys Pro 
                805                 810                 815     


Ser Gly Leu Gln Tyr Glu Ser Lys Leu Ser Gly Leu Lys Lys Pro Pro 
            820                 825                 830         


Thr Leu Gln Pro Ser Lys Glu Ala Cys Phe Leu Glu His Leu His Lys 
        835                 840                 845             


His Gln Gly Ser Val Leu His Pro Asp Tyr Lys Thr Ala Phe Pro Ser 
    850                 855                 860                 


Phe Glu Asp Ala Leu His Arg Leu Leu Pro Tyr His Val Tyr Gln Gly 
865                 870                 875                 880 


Ala Leu Pro Ser Pro Ser Asp Tyr His Lys Val Asp Glu Glu Phe Glu 
                885                 890                 895     


Thr Val Ser Thr Gln Leu Leu Lys Arg Thr Gln Ala Met Leu Asn Lys 
            900                 905                 910         


Tyr Arg Leu Leu Leu Leu Glu Glu Ser Arg Arg Val Ser Pro Ser Ala 
        915                 920                 925             


Glu Met Val Met Ile Asp Arg Met Phe Ile Gln Glu Glu Lys Thr Thr 
    930                 935                 940                 


Leu Ala Leu Asp Lys Gln Leu Ala Lys Glu Lys Pro Asp Glu Tyr Val 
945                 950                 955                 960 


Ser Ser Ser Arg Ser Leu Gly Leu Pro Ile Ala Ala Ser Ser Glu Gly 
                965                 970                 975     


His Arg Leu Pro Gly His Gly Pro Leu Ser Ser Ser Ala Pro Gly Ala 
            980                 985                 990         


Ser Thr Gln Pro Pro Pro His Leu  Pro Thr Lys Leu Val  Ile Arg His 
        995                 1000                 1005             


Gly Gly  Ala Gly Gly Ser Pro  Ser Val Thr Trp Ala  Arg Ala Ser 
    1010                 1015                 1020             


Ser Ser  Leu Ser Ser Ser Ser  Ser Ser Ser Ser Ala  Ala Ser Ser 
    1025                 1030                 1035             


Leu Asp  Ala Asp Glu Asp Gly  Pro Met Pro Ser Arg  Asn Arg Pro 
    1040                 1045                 1050             


Pro Ile  Lys Thr Tyr Glu Ala  Arg Ser Arg Ile Gly  Leu Lys Leu 
    1055                 1060                 1065             


Lys Ile  Lys Gln Glu Ala Gly  Leu Ser Lys Val Val  His Asn Thr 
    1070                 1075                 1080             


Ala Leu  Asp Pro Val His Gln  Pro Pro Pro Pro Pro  Ala Thr Leu 
    1085                 1090                 1095             


Lys Val  Ala Glu Pro Pro Pro  Arg Pro Pro Pro Pro  Pro Pro Pro 
    1100                 1105                 1110             


Thr Gly  Gln Met Asn Gly Thr  Val Asp His Pro Pro  Pro Ala Ala 
    1115                 1120                 1125             


Pro Glu  Arg Lys Pro Leu Gly  Thr Ala Pro His Cys  Pro Arg Leu 
    1130                 1135                 1140             


Pro Leu  Arg Lys Thr Tyr Arg  Glu Asn Val Gly Gly  Pro Gly Ala 
    1145                 1150                 1155             


Pro Glu  Gly Thr Pro Ala Gly  Arg Ala Arg Gly Gly  Ser Pro Ala 
    1160                 1165                 1170             


Pro Leu  Pro Ala Lys Val Asp  Glu Ala Thr Ser Gly  Leu Ile Arg 
    1175                 1180                 1185             


Glu Leu  Ala Ala Val Glu Asp  Glu Leu Tyr Gln Arg  Met Leu Lys 
    1190                 1195                 1200             


Gly Pro  Pro Pro Glu Pro Ala  Ala Ser Ala Ala Gln  Gly Thr Gly 
    1205                 1210                 1215             


Asp Pro  Asp Trp Glu Ala Pro  Gly Leu Pro Pro Ala  Lys Arg Arg 
    1220                 1225                 1230             


Lys Ser  Glu Ser Pro Asp Val  Asp Gln Ala Ser Phe  Ser Ser Asp 
    1235                 1240                 1245             


Ser Pro  Gln Asp Asp Thr Leu  Thr Glu His Leu Gln  Ser Ala Ile 
    1250                 1255                 1260             


Asp Ser  Ile Leu Asn Leu Gln  Gln Ala Pro Gly Arg  Thr Pro Ala 
    1265                 1270                 1275             


Pro Ser  Tyr Pro His Ala Ala  Ser Ala Gly Thr Pro  Ala Ser Pro 
    1280                 1285                 1290             


Pro Pro  Leu His Arg Pro Glu  Ala Tyr Pro Pro Ser  Ser His Asn 
    1295                 1300                 1305             


Gly Gly  Leu Gly Ala Arg Thr  Leu Thr Arg 
    1310                 1315             


<210>  265
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  265

Met Gly Arg Pro Glu Ser Ala Gly Gly Gly Ser Arg Gly Pro Phe Glu 
1               5                   10                  15      


Gly Gly Gly Arg Ala Arg Arg Ala Gly Gly Ile Phe Leu Thr Leu Ser 
            20                  25                  30          


Ile Leu Arg Thr Arg Asp Leu Pro Ser Gly Ala Met Ser Glu Gly Val 
        35                  40                  45              


Asp Leu Ile Asp Ile Tyr Ala Asp Glu Glu Phe Asn Gln Asp Pro Glu 
    50                  55                  60                  


Phe Asn Asn Thr Asp Gln Ile Asp Leu Tyr Asp Asp Val Leu Thr Ala 
65                  70                  75                  80  


Thr Ser Gln Pro Ser Asp Asp Arg Ser Ser Ser Thr Glu Pro Pro Pro 
                85                  90                  95      


Pro Val Arg Gln Glu Pro Ser Pro Lys Pro Asn Asn Lys Thr Pro Ala 
            100                 105                 110         


Ile Leu Tyr Thr Tyr Ser Gly Leu Arg Asn Arg Arg Ala Ala Val Tyr 
        115                 120                 125             


Val Gly Ser Phe Ser Trp Trp Thr Thr Asp Gln Gln Leu Ile Gln Val 
    130                 135                 140                 


Ile Arg Ser Ile Gly Val Tyr Asp Val Val Glu Leu Lys Phe Ala Glu 
145                 150                 155                 160 


Asn Arg Ala Asn Gly Gln Ser Lys Gly Tyr Ala Glu Val Val Val Ala 
                165                 170                 175     


Ser Glu Asn Ser Val His Lys Leu Leu Glu Leu Leu Pro Gly Lys Val 
            180                 185                 190         


Leu Asn Gly Glu Lys Val Asp Val Arg Pro Ala Thr Arg Gln Asn Leu 
        195                 200                 205             


Ser Gln Phe Glu Ala Gln Ala Arg Lys Arg Glu Cys Val Arg Val Pro 
    210                 215                 220                 


Arg Gly Gly Ile Pro Pro Arg Ala His Ser Arg Asp Ser Ser Asp Ser 
225                 230                 235                 240 


Ala Asp Gly Arg Ala Thr Pro Ser Glu Asn Leu Val Pro Ser Ser Ala 
                245                 250                 255     


Arg Val Asp Lys Pro Pro Ser Val Leu Pro Tyr Phe Asn Arg Pro Pro 
            260                 265                 270         


Ser Ala Leu Pro Leu Met Gly Leu Pro Pro Pro Pro Ile Pro Pro Pro 
        275                 280                 285             


Pro Pro Leu Ser Ser Ser Phe Gly Val Pro Pro Pro Pro Pro Gly Ile 
    290                 295                 300                 


His Tyr Gln His Leu Met Pro Pro Pro Pro Arg Leu Pro Pro His Leu 
305                 310                 315                 320 


Ala Val Pro Pro Pro Gly Ala Ile Pro Pro Ala Leu His Leu Asn Pro 
                325                 330                 335     


Ala Phe Phe Pro Pro Pro Asn Ala Thr Val Gly Pro Pro Pro Asp Thr 
            340                 345                 350         


Tyr Met Lys Ala Ser Ala Pro Tyr Asn His His Gly Ser Arg Asp Ser 
        355                 360                 365             


Gly Pro Pro Pro Ser Thr Val Ser Glu Ala Glu Phe Glu Asp Ile Met 
    370                 375                 380                 


Lys Arg Asn Arg Ala Ile Ser Ser Ser Ala Ile Ser Lys Ala Val Ser 
385                 390                 395                 400 


Gly Ala Ser Ala Gly Asp Tyr Ser Asp Ala Ile Glu Thr Leu Leu Thr 
                405                 410                 415     


Ala Ile Ala Val Ile Lys Gln Ser Arg Val Ala Asn Asp Glu Arg Cys 
            420                 425                 430         


Arg Val Leu Ile Ser Ser Leu Lys Asp Cys Leu His Gly Ile Glu Ala 
        435                 440                 445             


Lys Ser Tyr Ser Val Gly Ala Ser Gly Ser Ser Ser Arg Lys Arg His 
    450                 455                 460                 


Arg Ser Arg Glu Arg Ser Pro Ser Arg Ser Arg Glu Ser Ser Arg Arg 
465                 470                 475                 480 


His Arg Asp Leu Leu His Asn Glu Asp Arg His Asp Asp Tyr Phe Gln 
                485                 490                 495     


Glu Arg Asn Arg Glu His Glu Arg His Arg Asp Arg Glu Arg Asp Arg 
            500                 505                 510         


His His 
        


<210>  266
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  266

Met Ser Glu Gly Val Asp Leu Ile Asp Ile Tyr Ala Asp Glu Glu Phe 
1               5                   10                  15      


Asn Gln Asp Pro Glu Phe Asn Asn Thr Asp Gln Ile Asp Leu Tyr Asp 
            20                  25                  30          


Asp Val Leu Thr Ala Thr Ser Gln Pro Ser Asp Asp Arg Ser Ser Ser 
        35                  40                  45              


Thr Glu Pro Pro Pro Pro Val Arg Gln Glu Pro Ser Pro Lys Pro Asn 
    50                  55                  60                  


Asn Lys Thr Pro Ala Ile Leu Tyr Thr Tyr Ser Gly Leu Arg Asn Arg 
65                  70                  75                  80  


Arg Ala Ala Val Tyr Val Gly Ser Phe Ser Trp Trp Thr Thr Asp Gln 
                85                  90                  95      


Gln Leu Ile Gln Val Ile Arg Ser Ile Gly Val Tyr Asp Val Val Glu 
            100                 105                 110         


Leu Lys Phe Ala Glu Asn Arg Ala Asn Gly Gln Ser Lys Gly Tyr Ala 
        115                 120                 125             


Glu Val Val Val Ala Ser Glu Asn Ser Val His Lys Leu Leu Glu Leu 
    130                 135                 140                 


Leu Pro Gly Lys Val Leu Asn Gly Glu Lys Val Asp Val Arg Pro Ala 
145                 150                 155                 160 


Thr Arg Gln Asn Leu Ser Gln Phe Glu Ala Gln Ala Arg Lys Arg Glu 
                165                 170                 175     


Cys Val Arg Val Pro Arg Gly Gly Ile Pro Pro Arg Ala His Ser Arg 
            180                 185                 190         


Asp Ser Ser Asp Ser Ala Asp Gly Arg Ala Thr Pro Ser Glu Asn Leu 
        195                 200                 205             


Val Pro Ser Ser Ala Arg Val Asp Lys Pro Pro Ser Val Leu Pro Tyr 
    210                 215                 220                 


Phe Asn Arg Pro Pro Ser Ala Leu Pro Leu Met Gly Leu Pro Pro Pro 
225                 230                 235                 240 


Pro Ile Pro Pro Pro Pro Pro Leu Ser Ser Ser Phe Gly Val Pro Pro 
                245                 250                 255     


Pro Pro Pro Gly Ile His Tyr Gln His Leu Met Pro Pro Pro Pro Arg 
            260                 265                 270         


Leu Pro Pro His Leu Ala Val Pro Pro Pro Gly Ala Ile Pro Pro Ala 
        275                 280                 285             


Leu His Leu Asn Pro Ala Phe Phe Pro Pro Pro Asn Ala Thr Val Gly 
    290                 295                 300                 


Pro Pro Pro Asp Thr Tyr Met Lys Ala Ser Ala Pro Tyr Asn His His 
305                 310                 315                 320 


Gly Ser Arg Asp Ser Gly Pro Pro Pro Ser Thr Val Ser Glu Ala Glu 
                325                 330                 335     


Phe Glu Asp Ile Met Lys Arg Asn Arg Ala Ile Ser Ser Ser Ala Ile 
            340                 345                 350         


Ser Lys Ala Val Ser Gly Ala Ser Ala Gly Asp Tyr Ser Asp Ala Ile 
        355                 360                 365             


Glu Thr Leu Leu Thr Ala Ile Ala Val Ile Lys Gln Ser Arg Val Ala 
    370                 375                 380                 


Asn Asp Glu Arg Cys Arg Val Leu Ile Ser Ser Leu Lys Asp Cys Leu 
385                 390                 395                 400 


His Gly Ile Glu Ala Lys Ser Tyr Ser Val Gly Ala Ser Gly Ser Ser 
                405                 410                 415     


Ser Arg Lys Arg His Arg Ser Arg Glu Arg Ser Pro Ser Arg Ser Arg 
            420                 425                 430         


Glu Ser Ser Arg Arg His Arg Asp Leu Leu His Asn Glu Asp Arg His 
        435                 440                 445             


Asp Asp Tyr Phe Gln Glu Arg Asn Arg Glu His Glu Arg His Arg Asp 
    450                 455                 460                 


Arg Glu Arg Asp Arg His His 
465                 470     


<210>  267
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  267

Met Ser Glu Gly Val Asp Leu Ile Asp Ile Tyr Ala Asp Glu Glu Phe 
1               5                   10                  15      


Asn Gln Asp Pro Glu Phe Asn Asn Thr Asp Gln Ile Asp Leu Tyr Asp 
            20                  25                  30          


Asp Val Leu Thr Ala Thr Ser Gln Pro Ser Asp Asp Arg Ser Ser Ser 
        35                  40                  45              


Thr Glu Pro Pro Pro Pro Val Arg Gln Glu Pro Ser Pro Lys Pro Asn 
    50                  55                  60                  


Asn Lys Thr Pro Ala Ile Leu Tyr Thr Tyr Ser Gly Leu Arg Asn Arg 
65                  70                  75                  80  


Arg Ala Ala Val Tyr Val Gly Ser Phe Ser Trp Trp Thr Thr Asp Gln 
                85                  90                  95      


Gln Leu Ile Gln Val Ile Arg Ser Ile Gly Val Tyr Asp Val Val Glu 
            100                 105                 110         


Leu Lys Phe Ala Glu Asn Arg Ala Asn Gly Gln Ser Lys Gly Tyr Ala 
        115                 120                 125             


Glu Val Val Val Ala Ser Glu Asn Ser Val His Lys Leu Leu Glu Leu 
    130                 135                 140                 


Leu Pro 
145     


<210>  268
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  268

Met Ser Glu Gly Val Asp Leu Ile Asp Ile Tyr Ala Asp Glu Glu Phe 
1               5                   10                  15      


Asn Gln Asp Pro Glu Phe Asn Asn Thr Asp Gln Ile Asp Leu Tyr Asp 
            20                  25                  30          


Asp Val Leu Thr Ala Thr Ser Gln Pro Ser Asp Asp Arg Ser Ser Ser 
        35                  40                  45              


Thr Glu Pro Pro Pro Pro Val Arg Gln Glu Pro Ser Pro Lys Pro Asn 
    50                  55                  60                  


Asn Lys Thr Pro Ala Ile Leu Tyr Thr Tyr Ser Gly Leu Arg Asn Arg 
65                  70                  75                  80  


Arg Ala Ala Val Tyr Val Gly Ser Phe Ser Trp Trp Thr Thr Asp Gln 
                85                  90                  95      


Gln Leu Ile Gln Val Ile Arg Ser Ile Gly Val Tyr Asp Val Val Glu 
            100                 105                 110         


Leu Lys Phe Ala Glu Asn Arg Ala Asn Gly Gln Ser Lys Gly Tyr Ala 
        115                 120                 125             


Glu Val Val Val Ala Ser Glu Asn Ser Val His Lys Leu Leu Glu Leu 
    130                 135                 140                 


Leu Pro Gly Lys Val Leu Asn Gly Glu Lys Val Asp Val Arg Pro Ala 
145                 150                 155                 160 


Thr Arg Gln Asn Leu Ser Gln Phe Glu Ala Gln Ala Arg Lys Arg Ile 
                165                 170                 175     


Pro Pro Arg Ala His Ser Arg Asp Ser Ser Asp Ser Ala Asp Gly Arg 
            180                 185                 190         


Ala Thr Pro Ser Glu Asn Leu Val Pro Ser Ser Ala Arg 
        195                 200                 205 


<210>  269
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  269

Met Ser Glu Gly Val Asp Leu Ile Asp Ile Tyr Ala Asp Glu Glu Phe 
1               5                   10                  15      


Asn Gln Asp Pro Glu Phe Asn Asn Thr Asp Gln Ile Asp Leu Tyr Asp 
            20                  25                  30          


Asp Val Leu Thr Ala Thr Ser Gln Pro Ser Asp Asp Arg Ser Ser Ser 
        35                  40                  45              


Thr Glu Pro Pro Pro Pro Val Arg Gln Glu Pro Ser Pro Lys Pro Asn 
    50                  55                  60                  


Asn Lys Thr Pro Ala Ile Leu Tyr Thr Tyr Ser Gly Leu Arg Asn Arg 
65                  70                  75                  80  


Arg Ala Ala Val Tyr Val Gly Ser Phe Ser Trp Trp Thr Thr Asp Gln 
                85                  90                  95      


Gln Leu Ile Gln Val Ile Arg Ser Ile Gly Val Tyr Asp Val Val Glu 
            100                 105                 110         


Leu Lys Phe Ala Glu Asn Arg Ala Asn Gly Gln Ser Lys Gly Tyr Ala 
        115                 120                 125             


Glu Val Val Val Ala Ser Glu Asn Ser Val His Lys Leu Leu Glu Leu 
    130                 135                 140                 


Leu Pro Gly Lys Val Leu Asn Gly Glu Lys Val Asp Val Arg Pro Ala 
145                 150                 155                 160 


Thr Arg Gln Asn Leu Ser Gln Phe Glu Ala Gln Ala Arg Lys Arg Ile 
                165                 170                 175     


Pro Pro Arg Ala His Ser Arg Asp Ser Ser Asp Ser Ala Asp Gly Arg 
            180                 185                 190         


Ala Thr Pro Ser Glu Asn Leu Val Pro Ser Ser Ala Arg Val Asp Lys 
        195                 200                 205             


Pro Pro Ser Val Leu Pro Tyr Phe Asn Arg Pro Pro Ser Ala Leu Pro 
    210                 215                 220                 


Leu Met Gly Leu Pro Pro Pro Pro Ile Pro Pro Pro Pro Pro Leu Ser 
225                 230                 235                 240 


Ser Ser Phe Gly Val Pro Pro Pro Pro Pro Gly Ile His Tyr Gln His 
                245                 250                 255     


Leu Met Pro Pro Pro Pro Arg Leu Pro Pro His Leu Ala Val Pro Pro 
            260                 265                 270         


Pro Gly Ala Ile Pro Pro Ala Leu His Leu Asn Pro Ala Phe Phe Pro 
        275                 280                 285             


Pro Pro Asn Ala Thr Val Gly Pro Pro Pro Asp Thr Tyr Met Lys Ala 
    290                 295                 300                 


Ser Ala Pro Tyr Asn His His Gly Ser Arg Asp Ser Gly Pro Pro Pro 
305                 310                 315                 320 


Ser Thr Val Ser Glu Ala Glu Phe Glu Asp Ile Met Lys Arg Asn Arg 
                325                 330                 335     


Ala Ile Ser Ser Ser Ala Ile Ser Lys Ala Val Ser Gly Ala Ser Ala 
            340                 345                 350         


Gly Asp Tyr Ser Asp Ala Ile Glu Thr Leu Leu Thr Ala Ile Ala Val 
        355                 360                 365             


Ile Lys Gln Ser Arg Val Ala Asn Asp Glu Arg Cys Arg Val Leu Ile 
    370                 375                 380                 


Ser Ser Leu Lys Asp Cys Leu His Gly Ile Glu Ala Lys Ser Tyr Ser 
385                 390                 395                 400 


Val Gly Ala Ser Gly Ser Ser Ser Arg Lys Arg His Arg Ser Arg Glu 
                405                 410                 415     


Arg Ser Pro Ser Arg Ser Arg Glu Ser Ser Arg Arg His Arg Asp Leu 
            420                 425                 430         


Leu His Asn Glu Asp Arg His Asp Asp Tyr Phe Gln Glu Arg Asn Arg 
        435                 440                 445             


Glu His Glu Arg His Arg Asp Arg Glu Arg Asp Arg His His 
    450                 455                 460         


<210>  270
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  270

Met Ser Glu Gly Val Asp Leu Ile Asp Ile Tyr Ala Asp Glu Glu Phe 
1               5                   10                  15      


Asn Gln Asp Pro Glu Phe Asn Asn Thr Asp Gln Ile Asp Leu Tyr Asp 
            20                  25                  30          


Asp Val Leu Thr Ala Thr Ser Gln Pro Ser Asp Asp Arg Ser Ser Ser 
        35                  40                  45              


Thr Glu Pro Pro Pro Pro Val Arg Gln Glu Pro Ser Pro Lys Pro Asn 
    50                  55                  60                  


Asn Lys Thr Pro Ala Ile Leu Tyr Thr Tyr Ser Gly Leu Arg Asn Arg 
65                  70                  75                  80  


Arg Ala Ala Val Tyr Val Gly Ser Phe Ser Trp Trp Thr Thr Asp Gln 
                85                  90                  95      


Gln Leu Ile Gln Val Ile Arg Ser Ile Gly Val Tyr Asp Val Val Glu 
            100                 105                 110         


Leu Lys Phe Ala Glu Asn Arg Ala Asn Gly Gln Ser Lys Gly Tyr Ala 
        115                 120                 125             


Glu Val Val Val Ala Ser Glu Asn Ser Val His Lys Leu Leu Glu Leu 
    130                 135                 140                 


Leu Pro Gly Lys Val Leu Asn Gly Glu Lys Val Asp Val Arg Pro Ala 
145                 150                 155                 160 


Thr Arg Gln Asn Leu Ser Gln Phe Glu Ala Gln Ala Arg Lys Arg Ile 
                165                 170                 175     


Pro Pro Arg Ala His Ser Arg Asp Ser Ser Asp Ser Ala Asp Gly Arg 
            180                 185                 190         


Ala Thr Pro Ser Glu Asn Leu Val Pro Ser Ser Ala Arg Val Asp Lys 
        195                 200                 205             


Pro Pro Ser Val Leu Pro Tyr Phe Asn Arg Pro Pro Ser Ala Leu Pro 
    210                 215                 220                 


Leu Met Val Gly Pro Pro Pro Asp Thr Tyr Met Lys Ala Ser Ala Pro 
225                 230                 235                 240 


Tyr Asn His His Gly Ser Arg Asp Ser Gly Pro Pro Pro Ser Thr Val 
                245                 250                 255     


Ser Glu Ala Glu Phe Glu Asp Ile Met Lys Arg Asn Arg Ala Ile Ser 
            260                 265                 270         


Ser Ser Ala Ile Ser Lys Ala Val Ser Gly Ala Ser Ala Gly Asp Tyr 
        275                 280                 285             


Ser Asp Ala Ile Glu Thr Leu Leu Thr Ala Ile Ala Val Ile Lys Gln 
    290                 295                 300                 


Ser Arg Val Ala Asn Asp Glu Arg Cys Arg Val Leu Ile Ser Ser Leu 
305                 310                 315                 320 


Lys Asp Cys Leu His Gly Ile Glu Ala Lys Ser Tyr Ser Val Gly Ala 
                325                 330                 335     


Ser Gly Ser Ser Ser Arg Lys Arg His Arg Ser Arg Glu Arg Ser Pro 
            340                 345                 350         


Ser Arg Ser Arg Glu Ser Ser Arg Arg His Arg Asp Leu Leu His Asn 
        355                 360                 365             


Glu Asp Arg His Asp Asp 
    370                 


<210>  271
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  271

Met Ser Glu Gly Val Asp Leu Ile Asp Ile Tyr Ala Asp Glu Glu Phe 
1               5                   10                  15      


Asn Gln Asp Pro Glu Phe Asn Asn Thr Asp Gln Ile Asp Leu Tyr Asp 
            20                  25                  30          


Asp Val Leu Thr Ala Thr Ser Gln Pro Ser Asp Asp Arg Ser Ser Ser 
        35                  40                  45              


Thr Glu Pro Pro Pro Pro Val Arg Gln Glu Pro Ser Pro Lys Pro Asn 
    50                  55                  60                  


Asn Lys Thr Pro Ala Ile Leu Tyr Thr Tyr Ser Gly Leu Arg Asn Arg 
65                  70                  75                  80  


Arg Ala Ala Val Tyr Val Gly Ser Phe Ser Trp Trp Thr Thr Asp Gln 
                85                  90                  95      


Gln Leu Ile Gln Val Ile Arg Ser Ile Gly Val Tyr Asp Val Val Glu 
            100                 105                 110         


Leu Lys Phe Ala Glu Asn Arg Ala Asn Gly Gln Ser Lys Gly Tyr Ala 
        115                 120                 125             


Glu Val Val Val Ala Ser Glu Asn Ser Val His Lys Leu Leu Glu Leu 
    130                 135                 140                 


<210>  272
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  272

Met Ser Glu Gly Val Asp Leu Ile Asp Ile Tyr Ala Asp Glu Glu Phe 
1               5                   10                  15      


Asn Gln Asp Pro Glu Phe Asn Asn Thr Asp Gln Ile Asp Leu Tyr Asp 
            20                  25                  30          


Asp Val Leu Thr Ala Thr Ser Gln Pro Ser Asp Asp Arg Ser Ser Ser 
        35                  40                  45              


Thr Glu Pro Pro Pro Pro Val Arg Gln Glu Pro Ser Pro Lys Pro Asn 
    50                  55                  60                  


Asn Lys Thr Pro Ala Ile Leu Tyr Thr Tyr Ser Gly Leu Arg Asn Arg 
65                  70                  75                  80  


Arg Ala Ala Val Tyr Val Gly Ser Phe Ser Trp Trp Thr Thr Asp Gln 
                85                  90                  95      


Gln Leu Ile Gln Val Ile Arg Ser Ile Gly Val Tyr Asp Val Val Glu 
            100                 105                 110         


Leu Lys Phe Ala Glu Asn Arg Ala Asn Gly Gln Ser Lys Gly Tyr Ala 
        115                 120                 125             


Glu Val Val Val Ala Ser Glu Asn Ser Val 
    130                 135             


<210>  273
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  273

Met Ser Glu Gly Val Asp Leu Ile Asp Ile Tyr Ala Asp Glu Glu Phe 
1               5                   10                  15      


Asn Gln Asp Pro Glu Phe Asn Asn Thr Asp Gln Ile Asp Leu Tyr Asp 
            20                  25                  30          


Asp Val Leu Thr Ala Thr Ser Gln Pro Ser Asp Asp Arg Ser Ser Ser 
        35                  40                  45              


Thr Glu Pro Pro Pro Pro Val Arg Gln Glu Pro Ser Pro Lys Pro Asn 
    50                  55                  60                  


Asn Lys Thr Pro Ala Ile Leu Tyr Thr Tyr Ser Gly Leu Arg Asn Arg 
65                  70                  75                  80  


Arg Ala Ala Val Tyr Val Gly Ser Phe Ser Trp Val Gly Leu Ile Ser 
                85                  90                  95      


Glu Arg Glu Leu Ser 
            100     


<210>  274
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  274

Met Ser Glu Gly Val Asp Leu Ile Asp Ile Tyr Ala Asp Glu Glu Phe 
1               5                   10                  15      


Asn Gln Asp Pro Glu Phe Asn Asn Thr Asp Gln Ile Asp Leu Tyr Asp 
            20                  25                  30          


Asp Val Leu Thr Ala Thr Ser Gln Pro Ser Asp Asp Arg Ser Ser Ser 
        35                  40                  45              


Thr Glu Pro Pro Pro Pro Val Arg Gln Glu Pro Ser Pro Lys Pro Asn 
    50                  55                  60                  


Asn Lys Thr Pro Ala Ile Leu Tyr Thr Tyr Ser Gly Leu Arg Asn Arg 
65                  70                  75                  80  


Arg Ala Ala Val Tyr Val Gly Ser Phe Ser Trp Gly His Leu Arg Asp 
                85                  90                  95      


Glu Ile Ser Glu 
            100 


<210>  275
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  275

Met Ser Glu Gly Val Asp Leu Ile Asp Ile Tyr Ala Asp Glu Glu Phe 
1               5                   10                  15      


Asn Gln Asp Pro Glu Phe Asn Asn Thr Asp Gln Ile Asp Leu Tyr Asp 
            20                  25                  30          


Asp Val Leu Thr Ala Thr Ser Gln Pro Ser Asp Asp Arg Ser Ser Ser 
        35                  40                  45              


Thr Glu Pro Pro Pro Pro Val Arg Gln Glu Pro Ser Pro Lys Pro Asn 
    50                  55                  60                  


Asn Lys Thr Pro Ala Ile Leu Tyr Thr Tyr Ser Gly Leu Arg Asn Arg 
65                  70                  75                  80  


Arg Ala Ala Val Tyr Val Gly Ser Phe Ser Trp Glu Ser Met Met Trp 
                85                  90                  95      


Trp Ser 
        


<210>  276
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  276

Met Ser Glu Gly Val Asp Leu Ile Asp Ile Tyr Ala Asp Glu Glu Phe 
1               5                   10                  15      


Asn Gln Asp Pro Glu Phe Asn Asn Thr Asp Gln Ile Asp Leu Tyr Asp 
            20                  25                  30          


Asp Val Leu Thr Ala Thr Ser Gln Pro Ser Asp Asp Arg Ser Ser Ser 
        35                  40                  45              


Thr Glu Pro Pro Pro Pro Val Arg Gln Glu Pro Ser Pro Lys Pro Asn 
    50                  55                  60                  


Asn Lys Thr Pro Ala Ile Leu Tyr Thr Tyr Ser Gly Leu Arg Asn Arg 
65                  70                  75                  80  


Arg Ala Ala Val Tyr Val Gly Ser Phe Ser Trp Trp Thr Thr Asp Gln 
                85                  90                  95      


Gln Leu Ile Gln Val Cys 
            100         


<210>  277
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  277

Met Ser Glu Gly Val Asp Leu Ile Asp Ile Tyr Ala Asp Glu Glu Phe 
1               5                   10                  15      


Asn Gln Asp Pro Glu Phe Asn Asn Thr Asp Gln Ile Asp Leu Tyr Asp 
            20                  25                  30          


Asp Val Leu Thr Ala Thr Ser Gln Pro Ser Asp Asp Arg Ser Ser Ser 
        35                  40                  45              


Thr Glu Pro Pro Pro Pro Val Arg Gln Glu Pro Ser Pro Lys Pro Asn 
    50                  55                  60                  


Asn Lys Thr Pro Ala Ile Leu Tyr Thr Tyr Ser Gly Leu Arg Asn Arg 
65                  70                  75                  80  


Arg Ala Ala Val Tyr Val Gly Ser Phe Ser Trp Val Cys 
                85                  90              


<210>  278
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  278

Met Ser Glu Gly Val Asp Leu Ile Asp Ile Tyr Ala Asp Glu Glu Phe 
1               5                   10                  15      


Asn Gln Asp Pro Glu Phe Asn Asn Thr Asp Gln Ile Asp Leu Tyr Asp 
            20                  25                  30          


Asp Val Leu Thr Ala Thr Ser Gln Pro Ser Asp Asp Arg Ser Ser Ser 
        35                  40                  45              


Thr Glu Pro Pro Pro Pro Val Arg Gln Glu Pro Ser Pro Lys Pro Asn 
    50                  55                  60                  


Asn Lys Thr Pro Ala Ile Leu Tyr Thr Tyr Ser Gly Leu Arg Asn Arg 
65                  70                  75                  80  


Arg Ala Ala Val Tyr Val Gly Ser Phe Ser Trp Trp Thr Thr Asp Gln 
                85                  90                  95      


Gln Leu Ile Gln Val Ile Arg Ser Ile Gly Val Tyr Asp Val Val Glu 
            100                 105                 110         


Leu Lys Phe Ala Glu Asn Arg Ala Asn Gly Gln Ser Lys Gly Tyr Ala 
        115                 120                 125             


Glu Val Val Val Ala Ser Glu Asn Ser Val His Lys Leu Leu Glu Leu 
    130                 135                 140                 


Leu Pro Gly Lys Val Leu Asn Gly Glu Lys Val Asp Val Arg Pro Ala 
145                 150                 155                 160 


Thr Arg Gln Asn Leu Ser Gln Phe Glu Ala Gln Ala Arg Lys Arg Ile 
                165                 170                 175     


Pro Pro Arg Ala His Ser Arg Asp Ser Ser Asp Ser Ala Asp Gly Arg 
            180                 185                 190         


Ala Thr Pro Ser Glu Asn Leu Val Pro Ser Ser Ala Arg Val Asp Lys 
        195                 200                 205             


Pro Pro Ser Val Leu Pro Tyr Phe Asn Arg Pro Pro Ser Ala Leu Pro 
    210                 215                 220                 


Leu Met Gly Leu Pro Pro Pro Pro Ile Pro Pro Pro Pro Pro Leu Ser 
225                 230                 235                 240 


Ser Ser Phe Gly Val Pro Pro Pro Pro Pro Gly Ile His Tyr Gln His 
                245                 250                 255     


Leu Met Pro Pro Pro Pro Arg Leu Pro Pro His Leu Ala Val Pro Pro 
            260                 265                 270         


Pro Gly Ala Ile Pro Pro Ala Leu His Leu Asn Pro Ala Phe Phe Pro 
        275                 280                 285             


<210>  279
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  279

Met Ser Glu Gly Val Asp Leu Ile Asp Ile Tyr Ala Asp Glu Glu Phe 
1               5                   10                  15      


Asn Gln Asp Pro Glu Phe Asn Asn Thr Asp Gln Ile Asp Leu Tyr Asp 
            20                  25                  30          


Asp Val Leu Thr Ala Thr Ser Gln Pro Ser Asp Asp Arg Ser Ser Ser 
        35                  40                  45              


Thr Glu Pro Pro Pro Pro Val Arg Gln Glu Pro Ser Pro Lys Pro Asn 
    50                  55                  60                  


Asn Lys Thr Pro Ala Ile Leu Tyr Thr Tyr Ser Gly Leu Arg Asn Arg 
65                  70                  75                  80  


Arg Ala Ala Val Tyr Val Gly Ser Phe Ser Trp Gln Gly His Leu Arg 
                85                  90                  95      


Asp Glu Ile Ser Glu 
            100     


<210>  280
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  280

Met Ser Glu Gly Val Asp Leu Ile Asp Ile Tyr Ala Asp Glu Glu Phe 
1               5                   10                  15      


Asn Gln Asp Pro Glu Phe Asn Asn Thr Asp Gln Ile Asp Leu Tyr Asp 
            20                  25                  30          


Asp Val Leu Thr Ala Thr Ser Gln Pro Ser Asp Asp Arg Ser Ser Ser 
        35                  40                  45              


Thr Glu Pro Pro Pro Pro Val Arg Gln Glu Pro Ser Pro Lys Pro Asn 
    50                  55                  60                  


Asn Lys Thr Pro Ala Ile Leu Tyr Thr Tyr Ser Gly Leu Arg Asn Arg 
65                  70                  75                  80  


Arg Ala Ala Val Tyr Val Gly Ser Phe Ser Trp Trp Thr Thr Asp Gln 
                85                  90                  95      


Gln Leu Ile Gln Val Ile Arg Ser Ile Gly Val Tyr Asp Val Val Glu 
            100                 105                 110         


Leu Lys Phe Ala Glu Asn Arg Ala Asn Gly Gln Ser Lys Gly Tyr Ala 
        115                 120                 125             


Glu Val Val Val Ala Ser Glu Asn Ser Val His Lys Leu Leu Glu Leu 
    130                 135                 140                 


Leu Pro Gly Lys Val Leu Asn Gly Glu Lys Val Asp Val Arg Pro Ala 
145                 150                 155                 160 


Thr Arg Gln Asn Leu Ser Gln Phe Glu Ala Gln Ala Arg Lys Arg Ile 
                165                 170                 175     


Pro Pro Arg Ala His Ser Arg Asp Ser Ser Asp Ser Ala Asp Gly Arg 
            180                 185                 190         


Ala Thr Pro Ser Glu Asn Leu Val Pro Ser Ser Ala Arg Val Asp Lys 
        195                 200                 205             


Pro Pro Ser Val Leu Pro Tyr Phe Asn Arg Pro 
    210                 215                 


<210>  281
<211>  668
<212>  PRT
<213>  Homo sapiens

<400>  281

Met Ala Ala Asn Met Tyr Arg Val Gly Asp Tyr Val Tyr Phe Glu Asn 
1               5                   10                  15      


Ser Ser Ser Asn Pro Tyr Leu Val Arg Arg Ile Glu Glu Leu Asn Lys 
            20                  25                  30          


Thr Ala Asn Gly Asn Val Glu Ala Lys Val Val Cys Leu Phe Arg Arg 
        35                  40                  45              


Arg Asp Ile Ser Ser Ser Leu Asn Ser Leu Ala Asp Ser Asn Ala Arg 
    50                  55                  60                  


Glu Phe Glu Glu Glu Ser Lys Gln Pro Gly Val Ser Glu Gln Gln Arg 
65                  70                  75                  80  


His Gln Leu Lys His Arg Glu Leu Phe Leu Ser Arg Gln Phe Glu Ser 
                85                  90                  95      


Leu Pro Ala Thr His Ile Arg Gly Lys Cys Ser Val Thr Leu Leu Asn 
            100                 105                 110         


Glu Thr Asp Ile Leu Ser Gln Tyr Leu Glu Lys Glu Asp Cys Phe Phe 
        115                 120                 125             


Tyr Ser Leu Val Phe Asp Pro Val Gln Lys Thr Leu Leu Ala Asp Gln 
    130                 135                 140                 


Gly Glu Ile Arg Val Gly Cys Lys Tyr Gln Ala Glu Ile Pro Asp Arg 
145                 150                 155                 160 


Leu Val Glu Gly Glu Ser Asp Asn Arg Asn Gln Gln Lys Met Glu Met 
                165                 170                 175     


Lys Val Trp Asp Pro Asp Asn Pro Leu Thr Asp Arg Gln Ile Asp Gln 
            180                 185                 190         


Phe Leu Val Val Ala Arg Ala Val Gly Thr Phe Ala Arg Ala Leu Asp 
        195                 200                 205             


Cys Ser Ser Ser Ile Arg Gln Pro Ser Leu His Met Ser Ala Ala Ala 
    210                 215                 220                 


Ala Ser Arg Asp Ile Thr Leu Phe His Ala Met Asp Thr Leu Gln Arg 
225                 230                 235                 240 


Asn Gly Tyr Asp Leu Ala Lys Ala Met Ser Thr Leu Val Pro Gln Gly 
                245                 250                 255     


Gly Pro Val Leu Cys Arg Asp Glu Met Glu Glu Trp Ser Ala Ser Glu 
            260                 265                 270         


Ala Met Leu Phe Glu Glu Ala Leu Glu Lys Tyr Gly Lys Asp Phe Asn 
        275                 280                 285             


Asp Ile Arg Gln Asp Phe Leu Pro Trp Lys Ser Leu Ala Ser Ile Val 
    290                 295                 300                 


Gln Phe Tyr Tyr Met Trp Lys Thr Thr Asp Arg Tyr Ile Gln Gln Lys 
305                 310                 315                 320 


Arg Leu Lys Ala Ala Glu Ala Asp Ser Lys Leu Lys Gln Val Tyr Ile 
                325                 330                 335     


Pro Thr Tyr Thr Lys Pro Asn Pro Asn Gln Ile Ile Ser Val Gly Ser 
            340                 345                 350         


Lys Pro Gly Met Asn Gly Ala Gly Phe Gln Lys Gly Leu Thr Cys Glu 
        355                 360                 365             


Ser Cys His Thr Thr Gln Ser Ala Gln Trp Tyr Ala Trp Gly Pro Pro 
    370                 375                 380                 


Asn Met Gln Cys Arg Leu Cys Ala Ser Cys Trp Ile Tyr Trp Lys Lys 
385                 390                 395                 400 


Tyr Gly Gly Leu Lys Thr Pro Thr Gln Leu Glu Gly Ala Thr Arg Gly 
                405                 410                 415     


Thr Thr Glu Pro His Ser Arg Gly His Leu Ser Arg Pro Glu Ala Gln 
            420                 425                 430         


Ser Leu Ser Pro Tyr Thr Thr Ser Ala Asn Arg Ala Lys Leu Leu Ala 
        435                 440                 445             


Lys Asn Arg Gln Thr Phe Leu Leu Gln Thr Thr Lys Leu Thr Arg Leu 
    450                 455                 460                 


Ala Arg Arg Met Cys Arg Asp Leu Leu Gln Pro Arg Arg Ala Ala Arg 
465                 470                 475                 480 


Arg Pro Tyr Ala Pro Ile Asn Ala Asn Ala Ile Lys Ala Glu Cys Ser 
                485                 490                 495     


Ile Arg Leu Pro Lys Ala Ala Lys Thr Pro Leu Lys Ile His Pro Leu 
            500                 505                 510         


Val Arg Leu Pro Leu Ala Thr Ile Val Lys Asp Leu Val Ala Gln Ala 
        515                 520                 525             


Pro Leu Lys Pro Lys Thr Pro Arg Gly Thr Lys Thr Pro Ile Asn Arg 
    530                 535                 540                 


Asn Gln Leu Ser Gln Asn Arg Gly Leu Gly Gly Ile Met Val Lys Arg 
545                 550                 555                 560 


Ala Tyr Glu Thr Met Ala Gly Ala Gly Val Pro Phe Ser Ala Asn Gly 
                565                 570                 575     


Arg Pro Leu Ala Ser Gly Ile Arg Ser Ser Ser Gln Pro Ala Ala Lys 
            580                 585                 590         


Arg Gln Lys Leu Asn Pro Ala Asp Ala Pro Asn Pro Val Val Phe Val 
        595                 600                 605             


Ala Thr Lys Asp Thr Arg Ala Leu Arg Lys Ala Leu Thr His Leu Glu 
    610                 615                 620                 


Met Arg Arg Ala Ala Arg Arg Pro Asn Leu Pro Leu Lys Val Lys Pro 
625                 630                 635                 640 


Thr Leu Ile Ala Val Arg Pro Pro Val Pro Leu Pro Ala Pro Ser His 
                645                 650                 655     


Pro Ala Ser Thr Asn Glu Pro Ile Val Leu Glu Asp 
            660                 665             


<210>  282
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  282

Met Glu Met Lys Val Trp Asp Pro Asp Asn Pro Leu Thr Asp Arg Gln 
1               5                   10                  15      


Ile Asp Gln Phe Leu Val Val Ala Arg Ala Val Gly Thr Phe Ala Arg 
            20                  25                  30          


Ala Leu Asp Cys Ser Ser Ser Ile Arg Gln Pro Ser Leu His Met Ser 
        35                  40                  45              


Ala Ala Ala Ala Ser Arg Asp Ile Thr Leu Phe His Ala Met Asp Thr 
    50                  55                  60                  


Leu Gln Arg Asn Gly Tyr Asp Leu Ala Lys Ala Met Ser Thr Leu Val 
65                  70                  75                  80  


Pro Gln Gly Gly Pro Val Leu Cys Arg Asp Glu Met Glu Glu Trp Ser 
                85                  90                  95      


Ala Ser Glu Ala Met Leu Phe Glu Glu Ala Leu Glu Lys Tyr Gly Lys 
            100                 105                 110         


Asp Phe Asn Asp Ile Arg Gln Asp Phe Leu Pro Trp Lys Ser Leu Ala 
        115                 120                 125             


Ser Ile Val Gln Phe Tyr Tyr Met Trp Lys Thr Thr Asp Arg Tyr Ile 
    130                 135                 140                 


Gln Gln Lys Arg Leu Lys Ala Ala Glu Ala Asp Ser Lys Leu Lys Gln 
145                 150                 155                 160 


Val Tyr Ile Pro Thr Tyr Thr Lys Pro Asn Pro Asn Gln Ile Ile Ser 
                165                 170                 175     


Val Gly Ser Lys Pro Gly Met Asn Gly Ala Gly Phe Gln Lys Gly Leu 
            180                 185                 190         


Thr Cys Glu Ser Cys His Thr Thr Gln Ser Ala Gln Trp Tyr Ala Trp 
        195                 200                 205             


Gly Pro Pro Asn Met Gln Cys Arg Leu Cys Ala Ser Cys Trp Ile Tyr 
    210                 215                 220                 


Trp Lys Lys Tyr Gly Gly Leu Lys Thr Pro Thr Gln Leu Glu Gly Ala 
225                 230                 235                 240 


Thr Arg Gly Thr Thr Glu Pro His Ser Arg Gly His Leu Ser Arg Pro 
                245                 250                 255     


Glu Ala Gln Ser Leu Ser Pro Tyr Thr Thr Ser Ala Asn Arg Ala Lys 
            260                 265                 270         


Leu Leu Ala Lys Asn Arg Gln Thr Phe Leu Leu Gln Thr Thr Lys Leu 
        275                 280                 285             


Thr Arg Leu Ala Arg Arg Met Cys Arg Asp Leu Leu Gln Pro Arg Arg 
    290                 295                 300                 


Ala Ala Arg Arg Pro Tyr Ala Pro Ile Asn Ala Asn Ala Ile Lys Ala 
305                 310                 315                 320 


Glu Cys Ser Ile Arg Leu Pro Lys Ala Ala Lys Thr Pro Leu Lys Ile 
                325                 330                 335     


His Pro Leu Val Arg Leu Pro Leu Ala Thr Ile Val Lys Asp Leu Val 
            340                 345                 350         


Ala Gln Ala Pro Leu Lys Pro Lys Thr Pro Arg Gly Thr Lys Thr Pro 
        355                 360                 365             


Ile Asn Arg Asn Gln Leu Ser Gln Asn Arg Gly Leu Gly Gly Ile Met 
    370                 375                 380                 


Val Lys Arg Ala Tyr Glu Thr Met Ala Gly Ala Gly Val Pro Phe Ser 
385                 390                 395                 400 


Ala Asn Gly Arg Pro Leu Ala Ser Gly Ile Arg Ser Ser Ser Gln Pro 
                405                 410                 415     


Ala Ala Lys Arg Gln Lys Leu Asn Pro Ala Asp Ala Pro Asn Pro Val 
            420                 425                 430         


Val Phe Val Ala Thr Lys Asp Thr Arg Ala Leu Arg Lys Ala Leu Thr 
        435                 440                 445             


His Leu Glu Met Arg Arg Ala Ala Arg Arg Pro Asn Leu Pro Leu Lys 
    450                 455                 460                 


Val Lys Pro Thr Leu Ile Ala Val Arg Pro Pro Val Pro Leu Pro Ala 
465                 470                 475                 480 


Pro Ser His Pro Ala Ser Thr Asn Glu Pro Ile Val Leu Glu Asp 
                485                 490                 495 


<210>  283
<211>  397
<212>  PRT
<213>  Homo sapiens

<400>  283

Met Asn Ala Gly Ser Asp Pro Val Val Ile Val Ser Ala Ala Arg Thr 
1               5                   10                  15      


Ile Ile Gly Ser Phe Asn Gly Ala Leu Ala Ala Val Pro Val Gln Asp 
            20                  25                  30          


Leu Gly Ser Thr Val Ile Lys Glu Val Leu Lys Arg Ala Thr Val Ala 
        35                  40                  45              


Pro Glu Asp Val Ser Glu Val Ile Phe Gly His Val Leu Ala Ala Gly 
    50                  55                  60                  


Cys Gly Gln Asn Pro Val Arg Gln Ala Ser Val Gly Ala Gly Ile Pro 
65                  70                  75                  80  


Tyr Ser Val Pro Ala Trp Ser Cys Gln Met Ile Cys Gly Ser Gly Leu 
                85                  90                  95      


Lys Ala Val Cys Leu Ala Val Gln Ser Ile Gly Ile Gly Asp Ser Ser 
            100                 105                 110         


Ile Val Val Ala Gly Gly Met Glu Asn Met Ser Lys Ala Pro His Leu 
        115                 120                 125             


Ala Tyr Leu Arg Thr Gly Val Lys Ile Gly Glu Met Pro Leu Thr Asp 
    130                 135                 140                 


Ser Ile Leu Cys Asp Gly Leu Thr Asp Ala Phe His Asn Cys His Met 
145                 150                 155                 160 


Gly Ile Thr Ala Glu Asn Val Ala Lys Lys Trp Gln Val Ser Arg Glu 
                165                 170                 175     


Asp Gln Asp Lys Val Ala Val Leu Ser Gln Asn Arg Thr Glu Asn Ala 
            180                 185                 190         


Gln Lys Ala Gly His Phe Asp Lys Glu Ile Val Pro Val Leu Val Ser 
        195                 200                 205             


Thr Arg Lys Gly Leu Ile Glu Val Lys Thr Asp Glu Phe Pro Arg His 
    210                 215                 220                 


Gly Ser Asn Ile Glu Ala Met Ser Lys Leu Lys Pro Tyr Phe Leu Thr 
225                 230                 235                 240 


Asp Gly Thr Gly Thr Val Thr Pro Ala Asn Ala Ser Gly Ile Asn Asp 
                245                 250                 255     


Gly Ala Ala Ala Val Val Leu Met Lys Lys Ser Glu Ala Asp Lys Arg 
            260                 265                 270         


Gly Leu Thr Pro Leu Ala Arg Ile Val Ser Trp Ser Gln Val Gly Val 
        275                 280                 285             


Glu Pro Ser Ile Met Gly Ile Gly Pro Ile Pro Ala Ile Lys Gln Ala 
    290                 295                 300                 


Val Thr Lys Ala Gly Trp Ser Leu Glu Asp Val Asp Ile Phe Glu Ile 
305                 310                 315                 320 


Asn Glu Ala Phe Ala Ala Val Ser Ala Ala Ile Val Lys Glu Leu Gly 
                325                 330                 335     


Leu Asn Pro Glu Lys Val Asn Ile Glu Gly Gly Ala Ile Ala Leu Gly 
            340                 345                 350         


His Pro Leu Gly Ala Ser Gly Cys Arg Ile Leu Val Thr Leu Leu His 
        355                 360                 365             


Thr Leu Glu Arg Met Gly Arg Ser Arg Gly Val Ala Ala Leu Cys Ile 
    370                 375                 380                 


Gly Gly Gly Met Gly Ile Ala Met Cys Val Gln Arg Glu 
385                 390                 395         


<210>  284
<211>  566
<212>  PRT
<213>  Homo sapiens

<400>  284

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala 
        35                  40                  45              


Ala Asp Leu Ala His Ala Gln Gln Gln Gln Gln Gln Ala Leu Gln Val 
    50                  55                  60                  


Ala Arg Gln Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln Val Ser Gly 
65                  70                  75                  80  


Leu Lys Ser Pro Lys Arg Asn Asp Lys Gln Pro Ala Leu Gln Val Pro 
                85                  90                  95      


Val Ser Val Ala Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met 
            100                 105                 110         


Gln Gln Ile Leu Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val 
        115                 120                 125             


Leu Leu Gln Gln Gln Gln Ala Leu Met Leu Gln Gln Gln Gln Leu Gln 
    130                 135                 140                 


Glu Phe Tyr Lys Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln 
145                 150                 155                 160 


Gln Gln His Ala Gly Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr 
                165                 170                 175     


Gln Gln Leu Ala Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln 
            180                 185                 190         


Gln Gln His Leu Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln 
        195                 200                 205             


Pro Gly Gln Pro Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile 
    210                 215                 220                 


Pro Thr Glu Leu Gln Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr 
225                 230                 235                 240 


Ala Glu Glu Thr Thr Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr 
                245                 250                 255     


Thr Cys Val Ser Ser Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn 
            260                 265                 270         


Pro His Ala Ser Thr Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg 
        275                 280                 285             


Glu Ser Leu Ser His Glu Glu His Pro His Ser His Pro Leu Tyr Gly 
    290                 295                 300                 


His Gly Val Cys Lys Trp Pro Gly Cys Glu Ala Val Cys Glu Asp Phe 
305                 310                 315                 320 


Gln Ser Phe Leu Lys His Leu Asn Ser Glu His Ala Leu Asp Asp Arg 
                325                 330                 335     


Ser Thr Ala Gln Cys Arg Val Gln Met Gln Val Val Gln Gln Leu Glu 
            340                 345                 350         


Leu Gln Leu Ala Lys Asp Lys Glu Arg Leu Gln Ala Met Met Thr His 
        355                 360                 365             


Leu His Val Lys Ser Thr Glu Pro Lys Ala Ala Pro Gln Pro Leu Asn 
    370                 375                 380                 


Leu Val Ser Ser Val Thr Leu Ser Lys Ser Ala Ser Glu Ala Ser Pro 
385                 390                 395                 400 


Gln Ser Leu Pro His Thr Pro Thr Thr Pro Thr Ala Pro Leu Thr Pro 
                405                 410                 415     


Val Thr Gln Gly Pro Ser Val Ile Thr Thr Thr Ser Met His Thr Val 
            420                 425                 430         


Gly Pro Ile Arg Arg Arg Tyr Ser Asp Lys Tyr Asn Val Pro Ile Ser 
        435                 440                 445             


Ser Ala Asp Ile Ala Gln Asn Gln Glu Phe Tyr Lys Asn Ala Glu Val 
    450                 455                 460                 


Arg Pro Pro Phe Thr Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu 
465                 470                 475                 480 


Ser Pro Glu Lys Gln Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr 
                485                 490                 495     


Arg Met Phe Ala Tyr Phe Arg Arg Asn Ala Ala Thr Trp Lys Asn Ala 
            500                 505                 510         


Val Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Asn 
        515                 520                 525             


Val Lys Gly Ala Val Trp Thr Val Asp Glu Val Glu Phe Gln Lys Arg 
    530                 535                 540                 


Arg Pro Gln Lys Ile Ser Gly Val Pro Phe Ala Pro Thr Ser His Cys 
545                 550                 555                 560 


Ile Ser Ala Leu Ser Glu 
                565     


<210>  285
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  285

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala 
        35                  40                  45              


Ala Asp Leu Ala His Ala Gln Gln Gln Gln Gln Gln Trp His Leu Ile 
    50                  55                  60                  


Asn His Gln Pro Ser Arg Ser Pro Ser Ser Trp Leu Lys Arg Leu Ile 
65                  70                  75                  80  


Ser Ser Pro Trp Glu Leu Glu Val Leu Gln Val Pro Leu Trp Gly Ala 
                85                  90                  95      


Val Ala Glu Thr Lys Met Ser Gly Pro Val Cys Gln Pro Asn Pro Ser 
            100                 105                 110         


Pro Phe 
        


<210>  286
<211>  677
<212>  PRT
<213>  Homo sapiens

<400>  286

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala 
        35                  40                  45              


Ala Asp Leu Ala His Ala Gln Gln Gln Gln Gln Gln Ala Leu Gln Val 
    50                  55                  60                  


Ala Arg Gln Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln Val Ser Gly 
65                  70                  75                  80  


Leu Lys Ser Pro Lys Arg Asn Asp Lys Gln Pro Ala Leu Gln Val Pro 
                85                  90                  95      


Val Ser Val Ala Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met 
            100                 105                 110         


Gln Gln Ile Leu Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val 
        115                 120                 125             


Leu Leu Gln Gln Gln Gln Ala Leu Met Leu Gln Gln Gln Gln Leu Gln 
    130                 135                 140                 


Glu Phe Tyr Lys Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln 
145                 150                 155                 160 


Gln Gln His Ala Gly Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr 
                165                 170                 175     


Gln Gln Leu Ala Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln 
            180                 185                 190         


Gln Gln His Leu Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln 
        195                 200                 205             


Pro Gly Gln Pro Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile 
    210                 215                 220                 


Pro Thr Glu Leu Gln Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr 
225                 230                 235                 240 


Ala Glu Glu Thr Thr Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr 
                245                 250                 255     


Thr Cys Val Ser Ser Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn 
            260                 265                 270         


Pro His Ala Ser Thr Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg 
        275                 280                 285             


Glu Ser Leu Ser His Glu Glu His Pro His Ser His Pro Leu Tyr Gly 
    290                 295                 300                 


His Gly Val Cys Lys Trp Pro Gly Cys Glu Ala Val Cys Glu Asp Phe 
305                 310                 315                 320 


Gln Ser Phe Leu Lys His Leu Asn Ser Glu His Ala Leu Asp Asp Arg 
                325                 330                 335     


Ser Thr Ala Gln Cys Arg Val Gln Met Gln Val Val Gln Gln Leu Glu 
            340                 345                 350         


Leu Gln Leu Ala Lys Asp Lys Glu Arg Leu Gln Ala Met Met Thr His 
        355                 360                 365             


Leu His Val Lys Ser Thr Glu Pro Lys Ala Ala Pro Gln Pro Leu Asn 
    370                 375                 380                 


Leu Val Ser Ser Val Thr Leu Ser Lys Ser Ala Ser Glu Ala Ser Pro 
385                 390                 395                 400 


Gln Ser Leu Pro His Thr Pro Thr Thr Pro Thr Ala Pro Leu Thr Pro 
                405                 410                 415     


Val Thr Gln Gly Pro Ser Val Ile Thr Thr Thr Ser Met His Thr Val 
            420                 425                 430         


Gly Pro Ile Arg Arg Arg Tyr Ser Asp Lys Tyr Asn Val Pro Ile Ser 
        435                 440                 445             


Ser Ala Asp Ile Ala Gln Asn Gln Glu Phe Tyr Lys Asn Ala Glu Val 
    450                 455                 460                 


Arg Pro Pro Phe Thr Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu 
465                 470                 475                 480 


Ser Pro Glu Lys Gln Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr 
                485                 490                 495     


Arg Met Phe Ala Tyr Phe Arg Arg Asn Ala Ala Thr Trp Lys Asn Ala 
            500                 505                 510         


Val Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Asn 
        515                 520                 525             


Val Lys Gly Ala Val Trp Thr Val Asp Glu Val Glu Phe Gln Lys Arg 
    530                 535                 540                 


Arg Pro Gln Lys Ile Ser Gly Asn Pro Ser Leu Ile Lys Asn Met Gln 
545                 550                 555                 560 


Ser Ser His Ala Tyr Cys Thr Pro Leu Asn Ala Ala Leu Gln Ala Ser 
                565                 570                 575     


Met Ala Glu Asn Ser Ile Pro Leu Tyr Thr Thr Ala Ser Met Gly Asn 
            580                 585                 590         


Pro Thr Leu Gly Asn Leu Ala Ser Ala Ile Arg Glu Glu Leu Asn Gly 
        595                 600                 605             


Ala Met Glu His Thr Asn Ser Asn Glu Ser Asp Ser Ser Pro Gly Arg 
    610                 615                 620                 


Ser Pro Met Gln Ala Val His Pro Val His Val Lys Glu Glu Pro Leu 
625                 630                 635                 640 


Asp Pro Glu Glu Ala Glu Gly Pro Leu Ser Leu Val Thr Thr Ala Asn 
                645                 650                 655     


His Ser Pro Asp Phe Asp His Asp Arg Asp Tyr Glu Asp Glu Pro Val 
            660                 665                 670         


Asn Glu Asp Met Glu 
        675         


<210>  287
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  287

Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met Gln Gln Ile Leu 
1               5                   10                  15      


Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val Leu Leu Gln Gln 
            20                  25                  30          


Gln Gln Ala Leu Met Leu Gln Gln Gln Gln Leu Gln Glu Phe Tyr Lys 
        35                  40                  45              


Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln Gln Gln His Ala 
    50                  55                  60                  


Gly Lys Gln Pro Lys Glu Gln Val Ala Thr Gln Gln Leu Ala Phe Gln 
65                  70                  75                  80  


Gln Gln Leu Leu Gln Met Gln Gln Leu Gln Gln Gln His Leu Leu Ser 
                85                  90                  95      


Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln Pro Gly Gln Pro Ala Leu 
            100                 105                 110         


Pro Leu Gln Pro Leu Ala Gln Gly Met Ile Pro Thr Glu Leu Gln Gln 
        115                 120                 125             


Leu Trp Lys Glu Val Thr Ser Ala His Thr Ala Glu Glu Thr Thr Gly 
    130                 135                 140                 


Asn Asn His Ser Ser Leu Asp Leu Thr Thr Thr Cys Val Ser Ser Ser 
145                 150                 155                 160 


Ala Pro Ser Lys Thr Ser Leu Ile Met Asn Pro His Ala Ser Thr Asn 
                165                 170                 175     


Gly Gln Leu Ser Val His Thr Pro Lys Arg Glu Ser Leu Ser His Glu 
            180                 185                 190         


Glu His Pro His Ser His Pro Leu Tyr Gly His Gly Val Cys Lys Trp 
        195                 200                 205             


Pro Gly Cys Glu Ala Val Cys Glu Asp Phe Gln Ser Phe Leu Lys His 
    210                 215                 220                 


Leu Asn Ser Glu His Ala Leu 
225                 230     


<210>  288
<211>  601
<212>  PRT
<213>  Homo sapiens

<400>  288

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala 
        35                  40                  45              


Ala Asp Leu Ala His Ala Gln Gln Gln Gln Gln Gln Ala Leu Gln Val 
    50                  55                  60                  


Ala Arg Gln Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln Val Ser Gly 
65                  70                  75                  80  


Leu Lys Ser Pro Lys Arg Asn Asp Lys Gln Pro Ala Leu Gln Gln Gln 
                85                  90                  95      


Gln Val Ala Thr Gln Gln Leu Ala Phe Gln Gln Gln Leu Leu Gln Met 
            100                 105                 110         


Gln Gln Leu Gln Gln Gln His Leu Leu Ser Leu Gln Arg Gln Gly Leu 
        115                 120                 125             


Leu Thr Ile Gln Pro Gly Gln Pro Ala Leu Pro Leu Gln Pro Leu Ala 
    130                 135                 140                 


Gln Gly Met Ile Pro Thr Glu Leu Gln Gln Leu Trp Lys Glu Val Thr 
145                 150                 155                 160 


Ser Ala His Thr Ala Glu Glu Thr Thr Gly Asn Asn His Ser Ser Leu 
                165                 170                 175     


Asp Leu Thr Thr Thr Cys Val Ser Ser Ser Ala Pro Ser Lys Thr Ser 
            180                 185                 190         


Leu Ile Met Asn Pro His Ala Ser Thr Asn Gly Gln Leu Ser Val His 
        195                 200                 205             


Thr Pro Lys Arg Glu Ser Leu Ser His Glu Glu His Pro His Ser His 
    210                 215                 220                 


Pro Leu Tyr Gly His Gly Val Cys Lys Trp Pro Gly Cys Glu Ala Val 
225                 230                 235                 240 


Cys Glu Asp Phe Gln Ser Phe Leu Lys His Leu Asn Ser Glu His Ala 
                245                 250                 255     


Leu Asp Asp Arg Ser Thr Ala Gln Cys Arg Val Gln Met Gln Val Val 
            260                 265                 270         


Gln Gln Leu Glu Leu Gln Leu Ala Lys Asp Lys Glu Arg Leu Gln Ala 
        275                 280                 285             


Met Met Thr His Leu His Val Lys Ser Thr Glu Pro Lys Ala Ala Pro 
    290                 295                 300                 


Gln Pro Leu Asn Leu Val Ser Ser Val Thr Leu Ser Lys Ser Ala Ser 
305                 310                 315                 320 


Glu Ala Ser Pro Gln Ser Leu Pro His Thr Pro Thr Thr Pro Thr Ala 
                325                 330                 335     


Pro Leu Thr Pro Val Thr Gln Gly Pro Ser Val Ile Thr Thr Thr Ser 
            340                 345                 350         


Met His Thr Val Gly Pro Ile Arg Arg Arg Tyr Ser Asp Lys Tyr Asn 
        355                 360                 365             


Val Pro Ile Ser Ser Ala Asp Ile Ala Gln Asn Gln Glu Phe Tyr Lys 
    370                 375                 380                 


Asn Ala Glu Val Arg Pro Pro Phe Thr Tyr Ala Ser Leu Ile Arg Gln 
385                 390                 395                 400 


Ala Ile Leu Glu Ser Pro Glu Lys Gln Leu Thr Leu Asn Glu Ile Tyr 
                405                 410                 415     


Asn Trp Phe Thr Arg Met Phe Ala Tyr Phe Arg Arg Asn Ala Ala Thr 
            420                 425                 430         


Trp Lys Asn Ala Val Arg His Asn Leu Ser Leu His Lys Cys Phe Val 
        435                 440                 445             


Arg Val Glu Asn Val Lys Gly Ala Val Trp Thr Val Asp Glu Val Glu 
    450                 455                 460                 


Phe Gln Lys Arg Arg Pro Gln Lys Ile Ser Gly Asn Pro Ser Leu Ile 
465                 470                 475                 480 


Lys Asn Met Gln Ser Ser His Ala Tyr Cys Thr Pro Leu Asn Ala Ala 
                485                 490                 495     


Leu Gln Ala Ser Met Ala Glu Asn Ser Ile Pro Leu Tyr Thr Thr Ala 
            500                 505                 510         


Ser Met Gly Asn Pro Thr Leu Gly Asn Leu Ala Ser Ala Ile Arg Glu 
        515                 520                 525             


Glu Leu Asn Gly Ala Met Glu His Thr Asn Ser Asn Glu Ser Asp Ser 
    530                 535                 540                 


Ser Pro Gly Arg Ser Pro Met Gln Ala Val His Pro Val His Val Lys 
545                 550                 555                 560 


Glu Glu Pro Leu Asp Pro Glu Glu Ala Glu Gly Pro Leu Ser Leu Val 
                565                 570                 575     


Thr Thr Ala Asn His Ser Pro Asp Phe Asp His Asp Arg Asp Tyr Glu 
            580                 585                 590         


Asp Glu Pro Val Asn Glu Asp Met Glu 
        595                 600     


<210>  289
<211>  676
<212>  PRT
<213>  Homo sapiens

<400>  289

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala 
        35                  40                  45              


Ala Asp Leu Ala His Ala Gln Gln Gln Gln Gln Gln Ala Leu Gln Val 
    50                  55                  60                  


Ala Arg Gln Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln Val Ser Gly 
65                  70                  75                  80  


Leu Lys Ser Pro Lys Arg Asn Asp Lys Gln Pro Ala Leu Gln Val Pro 
                85                  90                  95      


Val Ser Val Ala Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met 
            100                 105                 110         


Gln Gln Ile Leu Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val 
        115                 120                 125             


Leu Leu Gln Gln Gln Gln Ala Leu Met Leu Gln Gln Gln Gln Leu Gln 
    130                 135                 140                 


Glu Phe Tyr Lys Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln 
145                 150                 155                 160 


Gln Gln His Ala Gly Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr 
                165                 170                 175     


Gln Gln Leu Ala Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln 
            180                 185                 190         


Gln Gln His Leu Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln 
        195                 200                 205             


Pro Gly Gln Pro Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile 
    210                 215                 220                 


Pro Thr Glu Leu Gln Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr 
225                 230                 235                 240 


Ala Glu Glu Thr Thr Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr 
                245                 250                 255     


Thr Cys Val Ser Ser Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn 
            260                 265                 270         


Pro His Ala Ser Thr Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg 
        275                 280                 285             


Glu Ser Leu Ser His Glu Glu His Pro His Ser His Pro Leu Tyr Gly 
    290                 295                 300                 


His Gly Val Cys Lys Trp Pro Gly Cys Glu Ala Val Cys Glu Asp Phe 
305                 310                 315                 320 


Gln Ser Phe Leu Lys His Leu Asn Ser Glu His Ala Leu Asp Asp Arg 
                325                 330                 335     


Ser Thr Ala Gln Cys Arg Val Gln Met Gln Val Val Gln Gln Leu Glu 
            340                 345                 350         


Leu Gln Leu Ala Lys Asp Lys Glu Arg Leu Gln Ala Met Met Thr His 
        355                 360                 365             


Leu His Val Lys Ser Thr Glu Pro Lys Ala Ala Pro Gln Pro Leu Asn 
    370                 375                 380                 


Leu Val Ser Ser Val Thr Leu Ser Lys Ser Ala Ser Glu Ala Ser Pro 
385                 390                 395                 400 


Gln Ser Leu Pro His Thr Pro Thr Thr Pro Thr Ala Pro Leu Thr Pro 
                405                 410                 415     


Val Thr Gln Gly Pro Ser Val Ile Thr Thr Thr Ser Met His Thr Val 
            420                 425                 430         


Gly Pro Ile Arg Arg Arg Tyr Ser Asp Lys Tyr Asn Val Pro Ile Ser 
        435                 440                 445             


Ser Asp Ile Ala Gln Asn Gln Glu Phe Tyr Lys Asn Ala Glu Val Arg 
    450                 455                 460                 


Pro Pro Phe Thr Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu Ser 
465                 470                 475                 480 


Pro Glu Lys Gln Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr Arg 
                485                 490                 495     


Met Phe Ala Tyr Phe Arg Arg Asn Ala Ala Thr Trp Lys Asn Ala Val 
            500                 505                 510         


Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Asn Val 
        515                 520                 525             


Lys Gly Ala Val Trp Thr Val Asp Glu Val Glu Phe Gln Lys Arg Arg 
    530                 535                 540                 


Pro Gln Lys Ile Ser Gly Asn Pro Ser Leu Ile Lys Asn Met Gln Ser 
545                 550                 555                 560 


Ser His Ala Tyr Cys Thr Pro Leu Asn Ala Ala Leu Gln Ala Ser Met 
                565                 570                 575     


Ala Glu Asn Ser Ile Pro Leu Tyr Thr Thr Ala Ser Met Gly Asn Pro 
            580                 585                 590         


Thr Leu Gly Asn Leu Ala Ser Ala Ile Arg Glu Glu Leu Asn Gly Ala 
        595                 600                 605             


Met Glu His Thr Asn Ser Asn Glu Ser Asp Ser Ser Pro Gly Arg Ser 
    610                 615                 620                 


Pro Met Gln Ala Val His Pro Val His Val Lys Glu Glu Pro Leu Asp 
625                 630                 635                 640 


Pro Glu Glu Ala Glu Gly Pro Leu Ser Leu Val Thr Thr Ala Asn His 
                645                 650                 655     


Ser Pro Asp Phe Asp His Asp Arg Asp Tyr Glu Asp Glu Pro Val Asn 
            660                 665                 670         


Glu Asp Met Glu 
        675     


<210>  290
<211>  576
<212>  PRT
<213>  Homo sapiens

<400>  290

Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met Gln Gln Ile Leu 
1               5                   10                  15      


Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val Leu Leu Gln Gln 
            20                  25                  30          


Gln Gln Ala Leu Met Leu Gln Gln Gln Leu Gln Glu Phe Tyr Lys Lys 
        35                  40                  45              


Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln Gln Gln His Ala Gly 
    50                  55                  60                  


Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr Gln Gln Leu Ala Phe 
65                  70                  75                  80  


Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln Gln Gln His Leu Leu 
                85                  90                  95      


Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln Pro Gly Gln Pro Ala 
            100                 105                 110         


Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile Pro Thr Glu Leu Gln 
        115                 120                 125             


Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr Ala Glu Glu Thr Thr 
    130                 135                 140                 


Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr Thr Cys Val Ser Ser 
145                 150                 155                 160 


Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn Pro His Ala Ser Thr 
                165                 170                 175     


Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg Glu Ser Leu Ser His 
            180                 185                 190         


Glu Glu His Pro His Ser His Pro Leu Tyr Gly His Gly Val Cys Lys 
        195                 200                 205             


Trp Pro Gly Cys Glu Ala Val Cys Glu Asp Phe Gln Ser Phe Leu Lys 
    210                 215                 220                 


His Leu Asn Ser Glu His Ala Leu Asp Asp Arg Ser Thr Ala Gln Cys 
225                 230                 235                 240 


Arg Val Gln Met Gln Val Val Gln Gln Leu Glu Leu Gln Leu Ala Lys 
                245                 250                 255     


Asp Lys Glu Arg Leu Gln Ala Met Met Thr His Leu His Val Lys Ser 
            260                 265                 270         


Thr Glu Pro Lys Ala Ala Pro Gln Pro Leu Asn Leu Val Ser Ser Val 
        275                 280                 285             


Thr Leu Ser Lys Ser Ala Ser Glu Ala Ser Pro Gln Ser Leu Pro His 
    290                 295                 300                 


Thr Pro Thr Thr Pro Thr Ala Pro Leu Thr Pro Val Thr Gln Gly Pro 
305                 310                 315                 320 


Ser Val Ile Thr Thr Thr Ser Met His Thr Val Gly Pro Ile Arg Arg 
                325                 330                 335     


Arg Tyr Ser Asp Lys Tyr Asn Val Pro Ile Ser Ser Ala Asp Ile Ala 
            340                 345                 350         


Gln Asn Gln Glu Phe Tyr Lys Asn Ala Glu Val Arg Pro Pro Phe Thr 
        355                 360                 365             


Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu Ser Pro Glu Lys Gln 
    370                 375                 380                 


Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr Arg Met Phe Ala Tyr 
385                 390                 395                 400 


Phe Arg Arg Asn Ala Ala Thr Trp Lys Asn Ala Val Arg His Asn Leu 
                405                 410                 415     


Ser Leu His Lys Cys Phe Val Arg Val Glu Asn Val Lys Gly Ala Val 
            420                 425                 430         


Trp Thr Val Asp Glu Val Glu Phe Gln Lys Arg Arg Pro Gln Lys Ile 
        435                 440                 445             


Ser Gly Asn Pro Ser Leu Ile Lys Asn Met Gln Ser Ser His Ala Tyr 
    450                 455                 460                 


Cys Thr Pro Leu Asn Ala Ala Leu Gln Ala Ser Met Ala Glu Asn Ser 
465                 470                 475                 480 


Ile Pro Leu Tyr Thr Thr Ala Ser Met Gly Asn Pro Thr Leu Gly Asn 
                485                 490                 495     


Leu Ala Ser Ala Ile Arg Glu Glu Leu Asn Gly Ala Met Glu His Thr 
            500                 505                 510         


Asn Ser Asn Glu Ser Asp Ser Ser Pro Gly Arg Ser Pro Met Gln Ala 
        515                 520                 525             


Val His Pro Val His Val Lys Glu Glu Pro Leu Asp Pro Glu Glu Ala 
    530                 535                 540                 


Glu Gly Pro Leu Ser Leu Val Thr Thr Ala Asn His Ser Pro Asp Phe 
545                 550                 555                 560 


Asp His Asp Arg Asp Tyr Glu Asp Glu Pro Val Asn Glu Asp Met Glu 
                565                 570                 575     


<210>  291
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  291

Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met Gln Gln Ile Leu 
1               5                   10                  15      


Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val Leu Leu Gln Gln 
            20                  25                  30          


Gln Gln Ala Leu Met Leu Gln Gln Gln Gln Leu Gln Glu Phe Tyr Lys 
        35                  40                  45              


Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln Gln Gln His Ala 
    50                  55                  60                  


Gly Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr Gln Gln Leu Ala 
65                  70                  75                  80  


Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln Gln Gln His Leu 
                85                  90                  95      


Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln Pro Gly Gln Pro 
            100                 105                 110         


Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly Met 
        115                 120             


<210>  292
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  292

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg 
        35      


<210>  293
<211>  207
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  293

Xaa Ala Leu Gln Val Pro Val Ser Val Ala Met Met Thr Pro Gln Val 
1               5                   10                  15      


Ile Thr Pro Gln Gln Met Gln Gln Ile Leu Gln Gln Gln Val Leu Ser 
            20                  25                  30          


Pro Gln Gln Leu Gln Val Leu Leu Gln Gln Gln Gln Ala Leu Met Leu 
        35                  40                  45              


Gln Gln Gln Gln Leu Gln Glu Phe Tyr Lys Lys Gln Gln Glu Gln Leu 
    50                  55                  60                  


Gln Leu Gln Leu Leu Gln Gln Gln His Ala Gly Lys Gln Pro Lys Glu 
65                  70                  75                  80  


Gln Gln Gln Val Ala Thr Gln Gln Leu Ala Phe Gln Gln Gln Leu Leu 
                85                  90                  95      


Gln Met Gln Gln Leu Gln Gln Gln His Leu Leu Ser Leu Gln Arg Gln 
            100                 105                 110         


Gly Leu Leu Thr Ile Gln Pro Gly Gln Pro Ala Leu Pro Leu Gln Pro 
        115                 120                 125             


Leu Ala Gln Gly Met Ile Pro Thr Glu Leu Gln Gln Leu Trp Lys Glu 
    130                 135                 140                 


Val Thr Ser Ala His Thr Ala Glu Glu Thr Thr Gly Asn Asn His Ser 
145                 150                 155                 160 


Ser Leu Asp Leu Thr Thr Thr Cys Val Ser Ser Ser Ala Pro Ser Lys 
                165                 170                 175     


Thr Ser Leu Ile Met Asn Pro His Ala Ser Thr Asn Gly Gln Leu Ser 
            180                 185                 190         


Val His Thr Pro Lys Arg Glu Arg Gln Ser Phe His Thr Gln Arg 
        195                 200                 205         


<210>  294
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  294

Met Gln Gln Leu Gln Gln Gln His Leu Leu Ser Leu Gln Arg Gln Gly 
1               5                   10                  15      


Leu Leu Thr Ile Gln Pro Gly Gln Pro Ala Leu Pro Leu Gln Pro Leu 
            20                  25                  30          


Ala Gln Gly Met Ile Pro Thr Glu Leu Gln Gln Leu Trp Lys Glu Val 
        35                  40                  45              


Thr Ser Ala His Thr Ala Glu Glu Thr Thr Gly Asn Asn His Ser Ser 
    50                  55                  60                  


Leu Asp Leu Thr Thr Thr Cys Val Ser Ser Ser Ala Pro Ser Lys Thr 
65                  70                  75                  80  


Ser Leu Ile Met Asn Pro His Ala Ser Thr Asn Gly Gln Leu Ser Val 
                85                  90                  95      


His Thr Pro Lys Arg Glu Ser Leu Ser His Glu Glu His Pro His Ser 
            100                 105                 110         


His Pro Leu Tyr Gly His Gly Val Cys Lys Trp Pro Gly Cys Glu Ala 
        115                 120                 125             


Val Cys Glu Asp Phe Gln Ser Phe Leu Lys His Leu Asn Ser Glu His 
    130                 135                 140                 


Ala Leu Asp Asp Arg Ser Thr Ala Gln Cys Arg Val Gln Met Gln Val 
145                 150                 155                 160 


Val Gln Gln Leu Glu Leu Gln Leu Ala Lys Asp Lys Glu Arg Leu Gln 
                165                 170                 175     


Ala Met Met Thr His Leu His Val Lys Ser Thr Glu Pro Lys Ala Ala 
            180                 185                 190         


Pro Gln Pro Leu Asn Leu Val Ser Ser Val Thr Leu Ser Lys Ser Ala 
        195                 200                 205             


Ser Glu Ala Ser Pro Gln Ser Leu Pro His Thr Pro Thr Thr Pro Thr 
    210                 215                 220                 


Ala Pro Leu Thr Pro Val Thr Gln Gly Pro Ser Val Ile Thr Thr Thr 
225                 230                 235                 240 


Ser Met His Thr Val Gly Pro Ile Arg Arg Arg Tyr Ser Asp Lys Tyr 
                245                 250                 255     


Asn Val Pro Ile Ser Ser Ala Asp Ile Ala Gln Asn Gln Glu Phe Tyr 
            260                 265                 270         


Lys Asn Ala Glu Val Arg Pro Pro Phe Thr Tyr Ala Ser Leu Ile Arg 
        275                 280                 285             


Gln Ala Ile Leu Glu Ser Pro Glu Lys Gln Leu Thr Leu Asn Glu Ile 
    290                 295                 300                 


Tyr Asn Trp Phe Thr Arg Met Phe Ala Tyr Phe Arg Arg Asn Ala Ala 
305                 310                 315                 320 


Thr Trp Lys Asn Ala Val Arg His Asn Leu Ser Leu His Lys Cys Phe 
                325                 330                 335     


Val Arg Val Glu Asn Val Lys Gly Ala Val Trp Thr Val Asp Glu Val 
            340                 345                 350         


Glu Phe Gln Lys Arg Arg Pro Gln Lys Ile Ser Gly Asn Pro Ser Leu 
        355                 360                 365             


Ile Lys Asn Met Gln Ser Ser His Ala Tyr Cys Thr Pro Leu Asn Ala 
    370                 375                 380                 


Ala Leu Gln Ala Ser Met Ala Glu Asn Ser Ile Pro Leu Tyr Thr Thr 
385                 390                 395                 400 


Ala Ser Met Gly Asn Pro Thr Leu Gly Asn Leu Ala Ser Ala Ile Arg 
                405                 410                 415     


Glu Glu Leu Asn Gly Ala Met Glu His Thr Asn Ser Asn Glu Ser Asp 
            420                 425                 430         


Ser Ser Pro Gly Arg Ser Pro Met Gln Ala Val His Pro Val His Val 
        435                 440                 445             


Lys Glu Glu Pro Leu Asp Pro Glu Glu Ala Glu Gly Pro Leu Ser Leu 
    450                 455                 460                 


Val Thr Thr Ala Asn His Ser Pro Asp Phe Asp His Asp Arg Asp Tyr 
465                 470                 475                 480 


Glu Asp Glu Pro Val Asn Glu Asp Met Glu 
                485                 490 


<210>  295
<211>  612
<212>  PRT
<213>  Homo sapiens

<400>  295

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala 
        35                  40                  45              


Ala Asp Leu Ala His Ala Gln Gln Gln Gln Gln Gln Ala Leu Gln Val 
    50                  55                  60                  


Ala Arg Gln Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln Val Ser Gly 
65                  70                  75                  80  


Leu Lys Ser Pro Lys Arg Asn Asp Lys Gln Pro Ala Leu Gln Val Pro 
                85                  90                  95      


Val Ser Val Ala Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met 
            100                 105                 110         


Gln Gln Ile Leu Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val 
        115                 120                 125             


Leu Leu Gln Gln Gln Gln Ala Leu Met Leu Gln Gln Gln Leu Gln Glu 
    130                 135                 140                 


Phe Tyr Lys Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln Gln 
145                 150                 155                 160 


Gln His Ala Gly Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr Gln 
                165                 170                 175     


Gln Leu Ala Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln Gln 
            180                 185                 190         


Gln His Leu Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln Pro 
        195                 200                 205             


Gly Gln Pro Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile Pro 
    210                 215                 220                 


Thr Glu Leu Gln Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr Ala 
225                 230                 235                 240 


Glu Glu Thr Thr Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr Thr 
                245                 250                 255     


Cys Val Ser Ser Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn Pro 
            260                 265                 270         


His Ala Ser Thr Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg Glu 
        275                 280                 285             


Ser Leu Ser His Glu Glu His Pro His Ser His Pro Leu Tyr Gly His 
    290                 295                 300                 


Gly Val Cys Lys Trp Pro Gly Cys Glu Ala Val Cys Glu Asp Phe Gln 
305                 310                 315                 320 


Ser Phe Leu Lys His Leu Asn Ser Glu His Ala Leu Asp Asp Arg Ser 
                325                 330                 335     


Thr Ala Gln Cys Arg Val Gln Met Gln Val Val Gln Gln Leu Glu Leu 
            340                 345                 350         


Gln Leu Ala Lys Asp Lys Glu Arg Leu Gln Ala Met Met Thr His Leu 
        355                 360                 365             


His Val Lys Ser Thr Glu Pro Lys Ala Ala Pro Gln Pro Leu Asn Leu 
    370                 375                 380                 


Val Ser Ser Val Thr Leu Ser Lys Ser Ala Ser Glu Ala Ser Pro Gln 
385                 390                 395                 400 


Ser Leu Pro His Thr Pro Thr Thr Pro Thr Ala Pro Leu Thr Pro Val 
                405                 410                 415     


Thr Gln Gly Pro Ser Val Ile Thr Thr Thr Ser Met His Thr Val Gly 
            420                 425                 430         


Pro Ile Arg Arg Arg Tyr Ser Asp Lys Tyr Asn Val Pro Ile Ser Ser 
        435                 440                 445             


Ala Asp Ile Ala Gln Asn Gln Glu Phe Tyr Lys Asn Ala Glu Val Arg 
    450                 455                 460                 


Pro Pro Phe Thr Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu Ser 
465                 470                 475                 480 


Pro Glu Lys Gln Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr Arg 
                485                 490                 495     


Met Phe Ala Tyr Phe Arg Arg Asn Ala Ala Thr Trp Lys Ala Ser Met 
            500                 505                 510         


Ala Glu Asn Ser Ile Pro Leu Tyr Thr Thr Ala Ser Met Gly Asn Pro 
        515                 520                 525             


Thr Leu Gly Asn Leu Ala Ser Ala Ile Arg Glu Glu Leu Asn Gly Ala 
    530                 535                 540                 


Met Glu His Thr Asn Ser Asn Glu Ser Asp Ser Ser Pro Gly Arg Ser 
545                 550                 555                 560 


Pro Met Gln Ala Val His Pro Val His Val Lys Glu Glu Pro Leu Asp 
                565                 570                 575     


Pro Glu Glu Ala Glu Gly Pro Leu Ser Leu Val Thr Thr Ala Asn His 
            580                 585                 590         


Ser Pro Asp Phe Asp His Asp Arg Asp Tyr Glu Asp Glu Pro Val Asn 
        595                 600                 605             


Glu Asp Met Glu 
    610         


<210>  296
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  296

Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met Gln Gln Ile Leu 
1               5                   10                  15      


Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val Leu Leu Gln Gln 
            20                  25                  30          


Gln Gln Ala Leu Met Leu Gln Gln Gln Gln Leu Gln Glu Phe Tyr Lys 
        35                  40                  45              


Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln Gln Gln His Ala 
    50                  55                  60                  


Gly Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr Gln Gln Leu Ala 
65                  70                  75                  80  


Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln Gln Gln His Leu 
                85                  90                  95      


Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln Pro Gly Gln Pro 
            100                 105                 110         


Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile Pro Thr Glu Leu 
        115                 120                 125             


Gln Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr Ala Glu Glu Thr 
    130                 135                 140                 


Thr Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr Thr Cys Val Ser 
145                 150                 155                 160 


Ser Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn Pro His Ala Ser 
                165                 170                 175     


Thr Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg Glu Ser Leu Ser 
            180                 185                 190         


His Glu Glu His Pro His Ser His Pro Leu Tyr Gly His Gly Val Cys 
        195                 200                 205             


Lys Trp Pro Gly Cys Glu Ala Val Cys Glu Asp Phe Gln Ser Phe Leu 
    210                 215                 220                 


Lys His Leu Asn Ser Glu His Ala Leu Asp Asp Arg Ser Thr Ala Gln 
225                 230                 235                 240 


Cys Arg Val Gln Met Gln Val Val Gln Gln Leu Glu Leu Gln Leu Ala 
                245                 250                 255     


Lys Asp Lys Glu Arg Leu Gln Ala Met Met Thr His Leu His Val Lys 
            260                 265                 270         


Ser Thr Glu Pro Lys Ala Ala Pro Gln Pro Leu Asn Leu Val Ser Ser 
        275                 280                 285             


Val Thr Leu Ser Lys Ser Ala Ser Glu Ala Ser Pro Gln Ser Leu Pro 
    290                 295                 300                 


His Thr Pro Thr Thr Pro Thr Ala Pro Leu Thr Pro Val Thr Gln Gly 
305                 310                 315                 320 


Pro Ser Val Ile Thr Thr Thr Ser Met His Thr Val Gly Pro Ile Arg 
                325                 330                 335     


Arg Arg Tyr Ser Asp Lys Tyr Asn Val Pro Ile Ser Ser Ala Asp Ile 
            340                 345                 350         


Ala Gln Asn Gln Glu Phe Tyr Lys Asn Ala Glu Val Arg Pro Pro Phe 
        355                 360                 365             


Thr Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu Ser Pro Glu Lys 
    370                 375                 380                 


Gln Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr Arg Met Phe Ala 
385                 390                 395                 400 


Tyr Phe Arg Arg Asn Ala Ala Thr Trp Lys 
                405                 410 


<210>  297
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  297

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala 
        35                  40                  45              


Ala Asp Leu Ala His Ala Gln Gln Gln Gln Gln Gln Ala Leu Gln Val 
    50                  55                  60                  


Ala Arg Gln Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln Val Ser Gly 
65                  70                  75                  80  


Leu Lys Ser Pro Lys Arg Asn Asp Lys Gln Pro Ala Leu Gln Val Pro 
                85                  90                  95      


Val Ser Val Ala Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met 
            100                 105                 110         


Gln Gln Ile Leu Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val 
        115                 120                 125             


Leu Leu Gln Gln Gln Gln Ala Leu Met Leu Gln Gln Gln Leu Gln Glu 
    130                 135                 140                 


Phe Tyr Lys Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln Gln 
145                 150                 155                 160 


Gln His Ala Gly Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr Gln 
                165                 170                 175     


Gln Leu Ala Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln Gln 
            180                 185                 190         


Gln His Leu Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln Pro 
        195                 200                 205             


Gly Gln Pro Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile Pro 
    210                 215                 220                 


Thr Glu Leu Gln Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr Ala 
225                 230                 235                 240 


Glu Glu Thr Thr Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr Thr 
                245                 250                 255     


Cys Val Ser Ser Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn Pro 
            260                 265                 270         


His Ala Ser Thr Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg Glu 
        275                 280                 285             


Ser Leu Ser His Glu Glu His Pro His Ser His Pro Leu Tyr Gly His 
    290                 295                 300                 


Gly Val Cys Lys Trp Pro Gly Cys Glu Ala Val Cys Glu Asp Phe Gln 
305                 310                 315                 320 


Ser Phe Leu Asn Leu Gln Lys Thr Lys Asn Ala Cys Lys Pro 
                325                 330                 


<210>  298
<211>  577
<212>  PRT
<213>  Homo sapiens

<400>  298

Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met Gln Gln Ile Leu 
1               5                   10                  15      


Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val Leu Leu Gln Gln 
            20                  25                  30          


Gln Gln Ala Leu Met Leu Gln Gln Gln Gln Leu Gln Glu Phe Tyr Lys 
        35                  40                  45              


Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln Gln Gln His Ala 
    50                  55                  60                  


Gly Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr Gln Gln Leu Ala 
65                  70                  75                  80  


Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln Gln Gln His Leu 
                85                  90                  95      


Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln Pro Gly Gln Pro 
            100                 105                 110         


Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile Pro Thr Glu Leu 
        115                 120                 125             


Gln Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr Ala Glu Glu Thr 
    130                 135                 140                 


Thr Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr Thr Cys Val Ser 
145                 150                 155                 160 


Ser Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn Pro His Ala Ser 
                165                 170                 175     


Thr Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg Glu Ser Leu Ser 
            180                 185                 190         


His Glu Glu His Pro His Ser His Pro Leu Tyr Gly His Gly Val Cys 
        195                 200                 205             


Lys Trp Pro Gly Cys Glu Ala Val Cys Glu Asp Phe Gln Ser Phe Leu 
    210                 215                 220                 


Lys His Leu Asn Ser Glu His Ala Leu Asp Asp Arg Ser Thr Ala Gln 
225                 230                 235                 240 


Cys Arg Val Gln Met Gln Val Val Gln Gln Leu Glu Leu Gln Leu Ala 
                245                 250                 255     


Lys Asp Lys Glu Arg Leu Gln Ala Met Met Thr His Leu His Val Lys 
            260                 265                 270         


Ser Thr Glu Pro Lys Ala Ala Pro Gln Pro Leu Asn Leu Val Ser Ser 
        275                 280                 285             


Val Thr Leu Ser Lys Ser Ala Ser Glu Ala Ser Pro Gln Ser Leu Pro 
    290                 295                 300                 


His Thr Pro Thr Thr Pro Thr Ala Pro Leu Thr Pro Val Thr Gln Gly 
305                 310                 315                 320 


Pro Ser Val Ile Thr Thr Thr Ser Met His Thr Val Gly Pro Ile Arg 
                325                 330                 335     


Arg Arg Tyr Ser Asp Lys Tyr Asn Val Pro Ile Ser Ser Ala Asp Ile 
            340                 345                 350         


Ala Gln Asn Gln Glu Phe Tyr Lys Asn Ala Glu Val Arg Pro Pro Phe 
        355                 360                 365             


Thr Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu Ser Pro Glu Lys 
    370                 375                 380                 


Gln Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr Arg Met Phe Ala 
385                 390                 395                 400 


Tyr Phe Arg Arg Asn Ala Ala Thr Trp Lys Asn Ala Val Arg His Asn 
                405                 410                 415     


Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Asn Val Lys Gly Ala 
            420                 425                 430         


Val Trp Thr Val Asp Glu Val Glu Phe Gln Lys Arg Arg Pro Gln Lys 
        435                 440                 445             


Ile Ser Gly Asn Pro Ser Leu Ile Lys Asn Met Gln Ser Ser His Ala 
    450                 455                 460                 


Tyr Cys Thr Pro Leu Asn Ala Ala Leu Gln Ala Ser Met Ala Glu Asn 
465                 470                 475                 480 


Ser Ile Pro Leu Tyr Thr Thr Ala Ser Met Gly Asn Pro Thr Leu Gly 
                485                 490                 495     


Asn Leu Ala Ser Ala Ile Arg Glu Glu Leu Asn Gly Ala Met Glu His 
            500                 505                 510         


Thr Asn Ser Asn Glu Ser Asp Ser Ser Pro Gly Arg Ser Pro Met Gln 
        515                 520                 525             


Ala Val His Pro Val His Val Lys Glu Glu Pro Leu Asp Pro Glu Glu 
    530                 535                 540                 


Ala Glu Gly Pro Leu Ser Leu Val Thr Thr Ala Asn His Ser Pro Asp 
545                 550                 555                 560 


Phe Asp His Asp Arg Asp Tyr Glu Asp Glu Pro Val Asn Glu Asp Met 
                565                 570                 575     


Glu 
    


<210>  299
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  299

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln 
    


<210>  300
<211>  676
<212>  PRT
<213>  Homo sapiens

<400>  300

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala 
        35                  40                  45              


Ala Asp Leu Ala His Ala Gln Gln Gln Gln Gln Gln Ala Leu Gln Val 
    50                  55                  60                  


Ala Arg Gln Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln Val Ser Gly 
65                  70                  75                  80  


Leu Lys Ser Pro Lys Arg Asn Asp Lys Gln Pro Ala Leu Gln Val Pro 
                85                  90                  95      


Val Ser Val Ala Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met 
            100                 105                 110         


Gln Gln Ile Leu Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val 
        115                 120                 125             


Leu Leu Gln Gln Gln Gln Ala Leu Met Leu Gln Gln Gln Leu Gln Glu 
    130                 135                 140                 


Phe Tyr Lys Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln Gln 
145                 150                 155                 160 


Gln His Ala Gly Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr Gln 
                165                 170                 175     


Gln Leu Ala Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln Gln 
            180                 185                 190         


Gln His Leu Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln Pro 
        195                 200                 205             


Gly Gln Pro Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile Pro 
    210                 215                 220                 


Thr Glu Leu Gln Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr Ala 
225                 230                 235                 240 


Glu Glu Thr Thr Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr Thr 
                245                 250                 255     


Cys Val Ser Ser Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn Pro 
            260                 265                 270         


His Ala Ser Thr Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg Glu 
        275                 280                 285             


Ser Leu Ser His Glu Glu His Pro His Ser His Pro Leu Tyr Gly His 
    290                 295                 300                 


Gly Val Cys Lys Trp Pro Gly Cys Glu Ala Val Cys Glu Asp Phe Gln 
305                 310                 315                 320 


Ser Phe Leu Lys His Leu Asn Ser Glu His Ala Leu Asp Asp Arg Ser 
                325                 330                 335     


Thr Ala Gln Cys Arg Val Gln Met Gln Val Val Gln Gln Leu Glu Leu 
            340                 345                 350         


Gln Leu Ala Lys Asp Lys Glu Arg Leu Gln Ala Met Met Thr His Leu 
        355                 360                 365             


His Val Lys Ser Thr Glu Pro Lys Ala Ala Pro Gln Pro Leu Asn Leu 
    370                 375                 380                 


Val Ser Ser Val Thr Leu Ser Lys Ser Ala Ser Glu Ala Ser Pro Gln 
385                 390                 395                 400 


Ser Leu Pro His Thr Pro Thr Thr Pro Thr Ala Pro Leu Thr Pro Val 
                405                 410                 415     


Thr Gln Gly Pro Ser Val Ile Thr Thr Thr Ser Met His Thr Val Gly 
            420                 425                 430         


Pro Ile Arg Arg Arg Tyr Ser Asp Lys Tyr Asn Val Pro Ile Ser Ser 
        435                 440                 445             


Ala Asp Ile Ala Gln Asn Gln Glu Phe Tyr Lys Asn Ala Glu Val Arg 
    450                 455                 460                 


Pro Pro Phe Thr Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu Ser 
465                 470                 475                 480 


Pro Glu Lys Gln Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr Arg 
                485                 490                 495     


Met Phe Ala Tyr Phe Arg Arg Asn Ala Ala Thr Trp Lys Asn Ala Val 
            500                 505                 510         


Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Asn Val 
        515                 520                 525             


Lys Gly Ala Val Trp Thr Val Asp Glu Val Glu Phe Gln Lys Arg Arg 
    530                 535                 540                 


Pro Gln Lys Ile Ser Gly Asn Pro Ser Leu Ile Lys Asn Met Gln Ser 
545                 550                 555                 560 


Ser His Ala Tyr Cys Thr Pro Leu Asn Ala Ala Leu Gln Ala Ser Met 
                565                 570                 575     


Ala Glu Asn Ser Ile Pro Leu Tyr Thr Thr Ala Ser Met Gly Asn Pro 
            580                 585                 590         


Thr Leu Gly Asn Leu Ala Ser Ala Ile Arg Glu Glu Leu Asn Gly Ala 
        595                 600                 605             


Met Glu His Thr Asn Ser Asn Glu Ser Asp Ser Ser Pro Gly Arg Ser 
    610                 615                 620                 


Pro Met Gln Ala Val His Pro Val His Val Lys Glu Glu Pro Leu Asp 
625                 630                 635                 640 


Pro Glu Glu Ala Glu Gly Pro Leu Ser Leu Val Thr Thr Ala Asn His 
                645                 650                 655     


Ser Pro Asp Phe Asp His Asp Arg Asp Tyr Glu Asp Glu Pro Val Asn 
            660                 665                 670         


Glu Asp Met Glu 
        675     


<210>  301
<211>  672
<212>  PRT
<213>  Homo sapiens

<400>  301

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala 
        35                  40                  45              


Ala Asp Leu Ala His Ala Gln Gln Gln Gln Gln Gln Val Ala Arg Gln 
    50                  55                  60                  


Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln Val Ser Gly Leu Lys Ser 
65                  70                  75                  80  


Pro Lys Arg Asn Asp Lys Gln Pro Ala Leu Gln Val Pro Val Ser Val 
                85                  90                  95      


Ala Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met Gln Gln Ile 
            100                 105                 110         


Leu Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val Leu Leu Gln 
        115                 120                 125             


Gln Gln Gln Ala Leu Met Leu Gln Gln Gln Leu Gln Glu Phe Tyr Lys 
    130                 135                 140                 


Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln Gln Gln His Ala 
145                 150                 155                 160 


Gly Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr Gln Gln Leu Ala 
                165                 170                 175     


Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln Gln Gln His Leu 
            180                 185                 190         


Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln Pro Gly Gln Pro 
        195                 200                 205             


Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile Pro Thr Glu Leu 
    210                 215                 220                 


Gln Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr Ala Glu Glu Thr 
225                 230                 235                 240 


Thr Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr Thr Cys Val Ser 
                245                 250                 255     


Ser Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn Pro His Ala Ser 
            260                 265                 270         


Thr Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg Glu Ser Leu Ser 
        275                 280                 285             


His Glu Glu His Pro His Ser His Pro Leu Tyr Gly His Gly Val Cys 
    290                 295                 300                 


Lys Trp Pro Gly Cys Glu Ala Val Cys Glu Asp Phe Gln Ser Phe Leu 
305                 310                 315                 320 


Lys His Leu Asn Ser Glu His Ala Leu Asp Asp Arg Ser Thr Ala Gln 
                325                 330                 335     


Cys Arg Val Gln Met Gln Val Val Gln Gln Leu Glu Leu Gln Leu Ala 
            340                 345                 350         


Lys Asp Lys Glu Arg Leu Gln Ala Met Met Thr His Leu His Val Lys 
        355                 360                 365             


Ser Thr Glu Pro Lys Ala Ala Pro Gln Pro Leu Asn Leu Val Ser Ser 
    370                 375                 380                 


Val Thr Leu Ser Lys Ser Ala Ser Glu Ala Ser Pro Gln Ser Leu Pro 
385                 390                 395                 400 


His Thr Pro Thr Thr Pro Thr Ala Pro Leu Thr Pro Val Thr Gln Gly 
                405                 410                 415     


Pro Ser Val Ile Thr Thr Thr Ser Met His Thr Val Gly Pro Ile Arg 
            420                 425                 430         


Arg Arg Tyr Ser Asp Lys Tyr Asn Val Pro Ile Ser Ser Asp Ile Ala 
        435                 440                 445             


Gln Asn Gln Glu Phe Tyr Lys Asn Ala Glu Val Arg Pro Pro Phe Thr 
    450                 455                 460                 


Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu Ser Pro Glu Lys Gln 
465                 470                 475                 480 


Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr Arg Met Phe Ala Tyr 
                485                 490                 495     


Phe Arg Arg Asn Ala Ala Thr Trp Lys Asn Ala Val Arg His Asn Leu 
            500                 505                 510         


Ser Leu His Lys Cys Phe Val Arg Val Glu Asn Val Lys Gly Ala Val 
        515                 520                 525             


Trp Thr Val Asp Glu Val Glu Phe Gln Lys Arg Arg Pro Gln Lys Ile 
    530                 535                 540                 


Ser Gly Asn Pro Ser Leu Ile Lys Asn Met Gln Ser Ser His Ala Tyr 
545                 550                 555                 560 


Cys Thr Pro Leu Asn Ala Ala Leu Gln Ala Ser Met Ala Glu Asn Ser 
                565                 570                 575     


Ile Pro Leu Tyr Thr Thr Ala Ser Met Gly Asn Pro Thr Leu Gly Asn 
            580                 585                 590         


Leu Ala Ser Ala Ile Arg Glu Glu Leu Asn Gly Ala Met Glu His Thr 
        595                 600                 605             


Asn Ser Asn Glu Ser Asp Ser Ser Pro Gly Arg Ser Pro Met Gln Ala 
    610                 615                 620                 


Val His Pro Val His Val Lys Glu Glu Pro Leu Asp Pro Glu Glu Ala 
625                 630                 635                 640 


Glu Gly Pro Leu Ser Leu Val Thr Thr Ala Asn His Ser Pro Asp Phe 
                645                 650                 655     


Asp His Asp Arg Asp Tyr Glu Asp Glu Pro Val Asn Glu Asp Met Glu 
            660                 665                 670         


<210>  302
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  302

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala 
        35                  40                  45              


Ala Asp Leu Ala His Ala Gln Gln Gln Gln Gln Gln Ala Leu Gln Val 
    50                  55                  60                  


Ala Arg Gln Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln Val Ser Gly 
65                  70                  75                  80  


Leu Lys Ser Pro Lys Arg Asn Asp Lys Gln Pro Ala Leu Gln Val Pro 
                85                  90                  95      


Val Ser Val Ala Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met 
            100                 105                 110         


Gln Gln Ile Leu Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val 
        115                 120                 125             


Leu Leu Gln Gln Gln Gln Ala Leu Met Leu Gln Gln Gln Gln Leu Gln 
    130                 135                 140                 


Glu Phe Tyr Lys 
145             


<210>  303
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  303

Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met Gln Gln Ile Leu 
1               5                   10                  15      


Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val Leu Leu Gln Gln 
            20                  25                  30          


Gln Gln Ala Leu Met Leu Gln Gln Gln Leu Gln Glu Phe Tyr Lys Lys 
        35                  40                  45              


Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln Gln Gln His Ala Gly 
    50                  55                  60                  


Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr Gln Gln Leu Ala Phe 
65                  70                  75                  80  


Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln Gln Gln His Leu Leu 
                85                  90                  95      


Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln Pro Gly Gln Pro Ala 
            100                 105                 110         


Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile Pro Thr Glu Leu Gln 
        115                 120                 125             


Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr Ala Glu Glu Thr Thr 
    130                 135                 140                 


Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr Thr Cys Val Ser Ser 
145                 150                 155                 160 


Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn Pro His Ala Ser Thr 
                165                 170                 175     


Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg Glu Ser Leu Ser His 
            180                 185                 190         


Glu Glu His Pro His Ser His Pro Leu Tyr Gly His Gly Val Cys Lys 
        195                 200                 205             


Trp Pro 
    210 


<210>  304
<211>  576
<212>  PRT
<213>  Homo sapiens

<400>  304

Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met Gln Gln Ile Leu 
1               5                   10                  15      


Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val Leu Leu Gln Gln 
            20                  25                  30          


Gln Gln Ala Leu Met Leu Gln Gln Gln Leu Gln Glu Phe Tyr Lys Lys 
        35                  40                  45              


Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln Gln Gln His Ala Gly 
    50                  55                  60                  


Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr Gln Gln Leu Ala Phe 
65                  70                  75                  80  


Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln Gln Gln His Leu Leu 
                85                  90                  95      


Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln Pro Gly Gln Pro Ala 
            100                 105                 110         


Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile Pro Thr Glu Leu Gln 
        115                 120                 125             


Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr Ala Glu Glu Thr Thr 
    130                 135                 140                 


Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr Thr Cys Val Ser Ser 
145                 150                 155                 160 


Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn Pro His Ala Ser Thr 
                165                 170                 175     


Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg Glu Ser Leu Ser His 
            180                 185                 190         


Glu Glu His Pro His Ser His Pro Leu Tyr Gly His Gly Val Cys Lys 
        195                 200                 205             


Trp Pro Gly Cys Glu Ala Val Cys Glu Asp Phe Gln Ser Phe Leu Lys 
    210                 215                 220                 


His Leu Asn Ser Glu His Ala Leu Asp Asp Arg Ser Thr Ala Gln Cys 
225                 230                 235                 240 


Arg Val Gln Met Gln Val Val Gln Gln Leu Glu Leu Gln Leu Ala Lys 
                245                 250                 255     


Asp Lys Glu Arg Leu Gln Ala Met Met Thr His Leu His Val Lys Ser 
            260                 265                 270         


Thr Glu Pro Lys Ala Ala Pro Gln Pro Leu Asn Leu Val Ser Ser Val 
        275                 280                 285             


Thr Leu Ser Lys Ser Ala Ser Glu Ala Ser Pro Gln Ser Leu Pro His 
    290                 295                 300                 


Thr Pro Thr Thr Pro Thr Ala Pro Leu Thr Pro Val Thr Gln Gly Pro 
305                 310                 315                 320 


Ser Val Ile Thr Thr Thr Ser Met His Thr Val Gly Pro Ile Arg Arg 
                325                 330                 335     


Arg Tyr Ser Asp Lys Tyr Asn Val Pro Ile Ser Ser Ala Asp Ile Ala 
            340                 345                 350         


Gln Asn Gln Glu Phe Tyr Lys Asn Ala Glu Val Arg Pro Pro Phe Thr 
        355                 360                 365             


Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu Ser Pro Glu Lys Gln 
    370                 375                 380                 


Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr Arg Met Phe Ala Tyr 
385                 390                 395                 400 


Phe Arg Arg Asn Ala Ala Thr Trp Lys Asn Ala Val Arg His Asn Leu 
                405                 410                 415     


Ser Leu His Lys Cys Phe Val Arg Val Glu Asn Val Lys Gly Ala Val 
            420                 425                 430         


Trp Thr Val Asp Glu Val Glu Phe Gln Lys Arg Arg Pro Gln Lys Ile 
        435                 440                 445             


Ser Gly Asn Pro Ser Leu Ile Lys Asn Met Gln Ser Ser His Ala Tyr 
    450                 455                 460                 


Cys Thr Pro Leu Asn Ala Ala Leu Gln Ala Ser Met Ala Glu Asn Ser 
465                 470                 475                 480 


Ile Pro Leu Tyr Thr Thr Ala Ser Met Gly Asn Pro Thr Leu Gly Asn 
                485                 490                 495     


Leu Ala Ser Ala Ile Arg Glu Glu Leu Asn Gly Ala Met Glu His Thr 
            500                 505                 510         


Asn Ser Asn Glu Ser Asp Ser Ser Pro Gly Arg Ser Pro Met Gln Ala 
        515                 520                 525             


Val His Pro Val His Val Lys Glu Glu Pro Leu Asp Pro Glu Glu Ala 
    530                 535                 540                 


Glu Gly Pro Leu Ser Leu Val Thr Thr Ala Asn His Ser Pro Asp Phe 
545                 550                 555                 560 


Asp His Asp Arg Asp Tyr Glu Asp Glu Pro Val Asn Glu Asp Met Glu 
                565                 570                 575     


<210>  305
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  305

Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met Gln Gln Ile Leu 
1               5                   10                  15      


Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val Leu Leu Gln Gln 
            20                  25                  30          


Gln Gln Ala Leu Met Leu Gln Gln Gln Gln Leu Gln Glu Phe Tyr Lys 
        35                  40                  45              


Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln Gln Gln His Ala 
    50                  55                  60                  


Gly Lys Gln Pro Lys Glu Phe Val Pro 
65                  70              


<210>  306
<211>  693
<212>  PRT
<213>  Homo sapiens

<400>  306

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala 
        35                  40                  45              


Ala Asp Leu Ala His Ala Gln Gln Gln Gln Gln Gln Ala Leu Gln Val 
    50                  55                  60                  


Ala Arg Gln Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln Val Ser Gly 
65                  70                  75                  80  


Leu Lys Ser Pro Lys Arg Asn Asp Lys Gln Pro Ala Leu Gln Val Pro 
                85                  90                  95      


Val Ser Val Ala Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met 
            100                 105                 110         


Gln Gln Ile Leu Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val 
        115                 120                 125             


Leu Leu Gln Gln Gln Gln Ala Leu Met Leu Gln Gln Gln Gln Leu Gln 
    130                 135                 140                 


Glu Phe Tyr Lys Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln 
145                 150                 155                 160 


Gln Gln His Ala Gly Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr 
                165                 170                 175     


Gln Gln Leu Ala Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln 
            180                 185                 190         


Gln Gln His Leu Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln 
        195                 200                 205             


Pro Gly Gln Pro Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile 
    210                 215                 220                 


Pro Thr Glu Leu Gln Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr 
225                 230                 235                 240 


Ala Glu Glu Thr Thr Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr 
                245                 250                 255     


Thr Cys Val Ser Ser Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn 
            260                 265                 270         


Pro His Ala Ser Thr Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg 
        275                 280                 285             


Glu Ser Leu Ser His Glu Glu His Pro His Ser His Pro Leu Tyr Gly 
    290                 295                 300                 


His Gly Val Cys Lys Trp Pro Gly Cys Glu Ala Val Cys Glu Asp Phe 
305                 310                 315                 320 


Gln Ser Phe Leu Lys His Leu Asn Ser Glu His Ala Leu Asp Asp Arg 
                325                 330                 335     


Ser Thr Ala Gln Cys Arg Val Gln Met Gln Val Val Gln Gln Leu Glu 
            340                 345                 350         


Leu Gln Leu Ala Lys Asp Lys Glu Arg Leu Gln Ala Met Met Thr His 
        355                 360                 365             


Leu His Val Lys Ser Thr Glu Pro Lys Ala Ala Pro Gln Pro Leu Asn 
    370                 375                 380                 


Leu Val Ser Ser Val Thr Leu Ser Lys Ser Ala Ser Glu Ala Ser Pro 
385                 390                 395                 400 


Gln Ser Leu Pro His Thr Pro Thr Thr Pro Thr Ala Pro Leu Thr Pro 
                405                 410                 415     


Val Thr Gln Gly Pro Ser Val Ile Thr Thr Thr Ser Met His Thr Val 
            420                 425                 430         


Gly Pro Ile Arg Arg Arg Tyr Ser Asp Lys Tyr Asn Val Pro Ile Ser 
        435                 440                 445             


Ser Ala Asp Ile Ala Gln Asn Gln Glu Phe Tyr Lys Asn Ala Glu Val 
    450                 455                 460                 


Arg Pro Pro Phe Thr Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu 
465                 470                 475                 480 


Ser Pro Glu Lys Gln Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr 
                485                 490                 495     


Arg Met Phe Ala Tyr Phe Arg Arg Asn Ala Ala Thr Trp Lys Gly Ala 
            500                 505                 510         


Ile Arg Thr Asn Leu Ser Leu His Lys Cys Phe Ile Arg Val Glu Asp 
        515                 520                 525             


Glu Phe Gly Ser Phe Trp Thr Val Asp Asp Glu Glu Phe Lys Arg Gly 
    530                 535                 540                 


Arg His Ile Gln Arg Gly Arg Pro Arg Lys Tyr Cys Pro Asp Glu Asn 
545                 550                 555                 560 


Phe Asp Glu Leu Val Ala His Asn Pro Ser Leu Ile Lys Asn Met Gln 
                565                 570                 575     


Ser Ser His Ala Tyr Cys Thr Pro Leu Asn Ala Ala Leu Gln Ala Ser 
            580                 585                 590         


Met Ala Glu Asn Ser Ile Pro Leu Tyr Thr Thr Ala Ser Met Gly Asn 
        595                 600                 605             


Pro Thr Leu Gly Asn Leu Ala Ser Ala Ile Arg Glu Glu Leu Asn Gly 
    610                 615                 620                 


Ala Met Glu His Thr Asn Ser Asn Glu Ser Asp Ser Ser Pro Gly Arg 
625                 630                 635                 640 


Ser Pro Met Gln Ala Val His Pro Val His Val Lys Glu Glu Pro Leu 
                645                 650                 655     


Asp Pro Glu Glu Ala Glu Gly Pro Leu Ser Leu Val Thr Thr Ala Asn 
            660                 665                 670         


His Ser Pro Asp Phe Asp His Asp Arg Asp Tyr Glu Asp Glu Pro Val 
        675                 680                 685             


Asn Glu Asp Met Glu 
    690             


<210>  307
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  307

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala 
        35                  40                  45              


Ala Asp Leu Ala His Ala Gln Gln Gln Gln Gln Gln Ala Leu Gln Val 
    50                  55                  60                  


Ala Arg Gln Leu Leu Leu Gln Gln Gln Gln Gln 
65                  70                  75  


<210>  308
<211>  675
<212>  PRT
<213>  Homo sapiens

<400>  308

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala 
        35                  40                  45              


Ala Asp Leu Ala His Ala Gln Gln Gln Gln Gln Gln Ala Leu Gln Val 
    50                  55                  60                  


Ala Arg Gln Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln Val Ser Gly 
65                  70                  75                  80  


Leu Lys Ser Pro Lys Arg Asn Asp Lys Gln Pro Ala Leu Gln Val Pro 
                85                  90                  95      


Val Ser Val Ala Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met 
            100                 105                 110         


Gln Gln Ile Leu Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val 
        115                 120                 125             


Leu Leu Gln Gln Gln Gln Ala Leu Met Leu Gln Gln Gln Leu Gln Glu 
    130                 135                 140                 


Phe Tyr Lys Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln Gln 
145                 150                 155                 160 


Gln His Ala Gly Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr Gln 
                165                 170                 175     


Gln Leu Ala Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln Gln 
            180                 185                 190         


Gln His Leu Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln Pro 
        195                 200                 205             


Gly Gln Pro Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile Pro 
    210                 215                 220                 


Thr Glu Leu Gln Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr Ala 
225                 230                 235                 240 


Glu Glu Thr Thr Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr Thr 
                245                 250                 255     


Cys Val Ser Ser Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn Pro 
            260                 265                 270         


His Ala Ser Thr Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg Glu 
        275                 280                 285             


Ser Leu Ser His Glu Glu His Pro His Ser His Pro Leu Tyr Gly His 
    290                 295                 300                 


Gly Val Cys Lys Trp Pro Gly Cys Glu Ala Val Cys Glu Asp Phe Gln 
305                 310                 315                 320 


Ser Phe Leu Lys His Leu Asn Ser Glu His Ala Leu Asp Asp Arg Ser 
                325                 330                 335     


Thr Ala Gln Cys Arg Val Gln Met Gln Val Val Gln Gln Leu Glu Leu 
            340                 345                 350         


Gln Leu Ala Lys Asp Lys Glu Arg Leu Gln Ala Met Met Thr His Leu 
        355                 360                 365             


His Val Lys Ser Thr Glu Pro Lys Ala Ala Pro Gln Pro Leu Asn Leu 
    370                 375                 380                 


Val Ser Ser Val Thr Leu Ser Lys Ser Ala Ser Glu Ala Ser Pro Gln 
385                 390                 395                 400 


Ser Leu Pro His Thr Pro Thr Thr Pro Thr Ala Pro Leu Thr Pro Val 
                405                 410                 415     


Thr Gln Gly Pro Ser Val Ile Thr Thr Thr Ser Met His Thr Val Gly 
            420                 425                 430         


Pro Ile Arg Arg Arg Tyr Ser Asp Lys Tyr Asn Val Pro Ile Ser Ser 
        435                 440                 445             


Asp Ile Ala Gln Asn Gln Glu Phe Tyr Lys Asn Ala Glu Val Arg Pro 
    450                 455                 460                 


Pro Phe Thr Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu Ser Pro 
465                 470                 475                 480 


Glu Lys Gln Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr Arg Met 
                485                 490                 495     


Phe Ala Tyr Phe Arg Arg Asn Ala Ala Thr Trp Lys Asn Ala Val Arg 
            500                 505                 510         


His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Asn Val Lys 
        515                 520                 525             


Gly Ala Val Trp Thr Val Asp Glu Val Glu Phe Gln Lys Arg Arg Pro 
    530                 535                 540                 


Gln Lys Ile Ser Gly Asn Pro Ser Leu Ile Lys Asn Met Gln Ser Ser 
545                 550                 555                 560 


His Ala Tyr Cys Thr Pro Leu Asn Ala Ala Leu Gln Ala Ser Met Ala 
                565                 570                 575     


Glu Asn Ser Ile Pro Leu Tyr Thr Thr Ala Ser Met Gly Asn Pro Thr 
            580                 585                 590         


Leu Gly Asn Leu Ala Ser Ala Ile Arg Glu Glu Leu Asn Gly Ala Met 
        595                 600                 605             


Glu His Thr Asn Ser Asn Glu Ser Asp Ser Ser Pro Gly Arg Ser Pro 
    610                 615                 620                 


Met Gln Ala Val His Pro Val His Val Lys Glu Glu Pro Leu Asp Pro 
625                 630                 635                 640 


Glu Glu Ala Glu Gly Pro Leu Ser Leu Val Thr Thr Ala Asn His Ser 
                645                 650                 655     


Pro Asp Phe Asp His Asp Arg Asp Tyr Glu Asp Glu Pro Val Asn Glu 
            660                 665                 670         


Asp Met Glu 
        675 


<210>  309
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  309

Met Gln Gln Leu Gln Gln Gln His Leu Leu Ser Leu Gln Arg Gln Gly 
1               5                   10                  15      


Leu Leu Thr Ile Gln Pro Gly Gln Pro Ala Leu Pro Leu Gln Pro Leu 
            20                  25                  30          


Ala Gln Gly Met Ile Pro Thr Glu Leu Gln Gln Leu Trp Lys Glu Val 
        35                  40                  45              


Thr Ser Ala His Thr Ala Glu Glu Thr Thr Gly Asn Asn His Ser Ser 
    50                  55                  60                  


Leu Asp Leu Thr Thr Thr Cys Val Ser Ser Ser Ala Pro Ser Lys Thr 
65                  70                  75                  80  


Ser Leu Ile Met Asn Pro His Ala Ser Thr Asn Gly Gln Leu Ser Val 
                85                  90                  95      


His Thr Pro Lys Arg Glu Ser Leu Ser His Glu Glu His Pro His Ser 
            100                 105                 110         


His Pro Leu Tyr Gly His Gly Val Cys Lys Trp Pro Gly Cys Glu Ala 
        115                 120                 125             


Val Cys Glu Asp Phe Gln Ser Phe Leu Lys His Leu Asn Ser Glu His 
    130                 135                 140                 


Ala Leu Asp Asp Arg Ser Thr Ala Gln Cys Arg Val Gln Met Gln Val 
145                 150                 155                 160 


Val Gln Gln Leu Glu Leu Gln Leu Ala Lys Asp Lys Glu Arg Leu Gln 
                165                 170                 175     


Ala Met Met Thr His Leu His Val Lys Ser Thr Glu Pro Lys Ala Ala 
            180                 185                 190         


Pro Gln Pro Leu Asn Leu Val Ser Ser Val Thr Leu Ser Lys Ser Ala 
        195                 200                 205             


Ser Glu 
    210 


<210>  310
<211>  628
<212>  PRT
<213>  Homo sapiens

<400>  310

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala 
        35                  40                  45              


Ala Asp Leu Ala His Ala Gln Gln Gln Gln Gln Gln Ala Leu Gln Val 
    50                  55                  60                  


Ala Arg Gln Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln Val Ser Gly 
65                  70                  75                  80  


Leu Lys Ser Pro Lys Arg Asn Asp Lys Gln Pro Ala Leu Gln Val Pro 
                85                  90                  95      


Val Ser Val Ala Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met 
            100                 105                 110         


Gln Gln Ile Leu Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val 
        115                 120                 125             


Leu Leu Gln Gln Gln Gln Ala Leu Met Leu Gln Gln Gln Gln Leu Gln 
    130                 135                 140                 


Glu Phe Tyr Lys Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln 
145                 150                 155                 160 


Gln Gln His Ala Gly Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr 
                165                 170                 175     


Gln Gln Leu Ala Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln 
            180                 185                 190         


Gln Gln His Leu Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln 
        195                 200                 205             


Pro Gly Gln Pro Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile 
    210                 215                 220                 


Pro Thr Glu Leu Gln Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr 
225                 230                 235                 240 


Ala Glu Glu Thr Thr Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr 
                245                 250                 255     


Thr Cys Val Ser Ser Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn 
            260                 265                 270         


Pro His Ala Ser Thr Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg 
        275                 280                 285             


Glu Ser Leu Ser His Glu Glu His Pro His Ser His Pro Leu Tyr Gly 
    290                 295                 300                 


His Gly Val Cys Lys Trp Pro Gly Cys Glu Ala Val Cys Glu Asp Phe 
305                 310                 315                 320 


Gln Ser Phe Leu Lys His Leu Asn Ser Glu His Ala Leu Asp Asp Arg 
                325                 330                 335     


Ser Thr Ala Gln Cys Arg Val Gln Met Gln Val Val Gln Gln Leu Glu 
            340                 345                 350         


Leu Gln Leu Ala Lys Asp Lys Glu Arg Leu Gln Ala Met Met Thr His 
        355                 360                 365             


Leu His Val Lys Ser Thr Glu Pro Lys Ala Ala Pro Gln Pro Leu Asn 
    370                 375                 380                 


Leu Val Ser Ser Val Thr Leu Ser Lys Ser Ala Ser Glu Ala Ser Pro 
385                 390                 395                 400 


Gln Ser Leu Pro His Thr Pro Thr Thr Pro Thr Ala Pro Leu Thr Pro 
                405                 410                 415     


Val Thr Gln Gly Pro Ser Val Ile Thr Thr Thr Ser Met His Thr Val 
            420                 425                 430         


Gly Pro Ile Arg Arg Arg Tyr Ser Asp Lys Tyr Asn Val Pro Ile Ser 
        435                 440                 445             


Ser Ala Asp Ile Ala Gln Asn Gln Glu Phe Tyr Lys Asn Ala Glu Val 
    450                 455                 460                 


Arg Pro Pro Phe Thr Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu 
465                 470                 475                 480 


Ser Pro Glu Lys Gln Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr 
                485                 490                 495     


Arg Met Phe Ala Tyr Phe Arg Arg Asn Ala Ala Thr Trp Lys Asn Ala 
            500                 505                 510         


Val Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Asn 
        515                 520                 525             


Val Lys Gly Ala Val Trp Thr Val Asp Glu Val Glu Phe Gln Lys Arg 
    530                 535                 540                 


Arg Pro Gln Lys Ile Ser Gly Asn Pro Ser Leu Ile Lys Asn Met Gln 
545                 550                 555                 560 


Ser Ser His Ala Tyr Cys Thr Pro Leu Asn Ala Ala Leu Gln Ala Ser 
                565                 570                 575     


Met Ala Glu Asn Ser Ile Pro Leu Tyr Thr Thr Ala Ser Met Gly Asn 
            580                 585                 590         


Pro Thr Leu Gly Asn Leu Ala Ser Ala Ile Arg Glu Glu Leu Asn Gly 
        595                 600                 605             


Ala Met Glu His Thr Asn Ser Asn Glu Ser Asp Ser Ser Pro Gly Arg 
    610                 615                 620                 


Ser Pro Met Gln 
625             


<210>  311
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  311

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala 
        35                  40                  45              


Ala Asp Leu Ala His Ala Gln Gln Gln 
    50                  55          


<210>  312
<211>  576
<212>  PRT
<213>  Homo sapiens

<400>  312

Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met Gln Gln Ile Leu 
1               5                   10                  15      


Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val Leu Leu Gln Gln 
            20                  25                  30          


Gln Gln Ala Leu Met Leu Gln Gln Gln Gln Leu Gln Glu Phe Tyr Lys 
        35                  40                  45              


Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln Gln Gln His Ala 
    50                  55                  60                  


Gly Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr Gln Gln Leu Ala 
65                  70                  75                  80  


Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln Gln Gln His Leu 
                85                  90                  95      


Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln Pro Gly Gln Pro 
            100                 105                 110         


Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile Pro Thr Glu Leu 
        115                 120                 125             


Gln Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr Ala Glu Glu Thr 
    130                 135                 140                 


Thr Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr Thr Cys Val Ser 
145                 150                 155                 160 


Ser Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn Pro His Ala Ser 
                165                 170                 175     


Thr Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg Glu Ser Leu Ser 
            180                 185                 190         


His Glu Glu His Pro His Ser His Pro Leu Tyr Gly His Gly Val Cys 
        195                 200                 205             


Lys Trp Pro Gly Cys Glu Ala Val Cys Glu Asp Phe Gln Ser Phe Leu 
    210                 215                 220                 


Lys His Leu Asn Ser Glu His Ala Leu Asp Asp Arg Ser Thr Ala Gln 
225                 230                 235                 240 


Cys Arg Val Gln Met Gln Val Val Gln Gln Leu Glu Leu Gln Leu Ala 
                245                 250                 255     


Lys Asp Lys Glu Arg Leu Gln Ala Met Met Thr His Leu His Val Lys 
            260                 265                 270         


Ser Thr Glu Pro Lys Ala Ala Pro Gln Pro Leu Asn Leu Val Ser Ser 
        275                 280                 285             


Val Thr Leu Ser Lys Ser Ala Ser Glu Ala Ser Pro Gln Ser Leu Pro 
    290                 295                 300                 


His Thr Pro Thr Thr Pro Thr Ala Pro Leu Thr Pro Val Thr Gln Gly 
305                 310                 315                 320 


Pro Ser Val Ile Thr Thr Thr Ser Met His Thr Val Gly Pro Ile Arg 
                325                 330                 335     


Arg Arg Tyr Ser Asp Lys Tyr Asn Val Pro Ile Ser Ser Asp Ile Ala 
            340                 345                 350         


Gln Asn Gln Glu Phe Tyr Lys Asn Ala Glu Val Arg Pro Pro Phe Thr 
        355                 360                 365             


Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu Ser Pro Glu Lys Gln 
    370                 375                 380                 


Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr Arg Met Phe Ala Tyr 
385                 390                 395                 400 


Phe Arg Arg Asn Ala Ala Thr Trp Lys Asn Ala Val Arg His Asn Leu 
                405                 410                 415     


Ser Leu His Lys Cys Phe Val Arg Val Glu Asn Val Lys Gly Ala Val 
            420                 425                 430         


Trp Thr Val Asp Glu Val Glu Phe Gln Lys Arg Arg Pro Gln Lys Ile 
        435                 440                 445             


Ser Gly Asn Pro Ser Leu Ile Lys Asn Met Gln Ser Ser His Ala Tyr 
    450                 455                 460                 


Cys Thr Pro Leu Asn Ala Ala Leu Gln Ala Ser Met Ala Glu Asn Ser 
465                 470                 475                 480 


Ile Pro Leu Tyr Thr Thr Ala Ser Met Gly Asn Pro Thr Leu Gly Asn 
                485                 490                 495     


Leu Ala Ser Ala Ile Arg Glu Glu Leu Asn Gly Ala Met Glu His Thr 
            500                 505                 510         


Asn Ser Asn Glu Ser Asp Ser Ser Pro Gly Arg Ser Pro Met Gln Ala 
        515                 520                 525             


Val His Pro Val His Val Lys Glu Glu Pro Leu Asp Pro Glu Glu Ala 
    530                 535                 540                 


Glu Gly Pro Leu Ser Leu Val Thr Thr Ala Asn His Ser Pro Asp Phe 
545                 550                 555                 560 


Asp His Asp Arg Asp Tyr Glu Asp Glu Pro Val Asn Glu Asp Met Glu 
                565                 570                 575     


<210>  313
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  313

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala 
        35                  40                  45              


Ala Asp Leu Ala His Ala Gln Gln Gln Gln Gln Gln Ala Leu Gln Val 
    50                  55                  60                  


Ala Arg Gln Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln Val Ser Gly 
65                  70                  75                  80  


Leu Lys Ser Pro Lys Arg Asn Asp Lys 
                85                  


<210>  314
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  314

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala 
        35                  40                  45              


Ala Asp Leu Ala His Ala Gln Gln Gln Gln Gln Gln Ala Leu Gln Val 
    50                  55                  60                  


Ala Arg Gln Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln Val Ser Gly 
65                  70                  75                  80  


Leu Lys Ser Pro Lys Arg Asn Asp Lys Gln Pro Ala Leu Gln Val Pro 
                85                  90                  95      


Val Ser Val Ala Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met 
            100                 105                 110         


Gln Gln Ile Leu Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val 
        115                 120                 125             


Leu Leu Gln Gln Gln Gln Ala Leu Met Leu Gln Gln Gln Gln Leu Gln 
    130                 135                 140                 


Glu Phe Tyr Lys Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln 
145                 150                 155                 160 


Gln Gln His Ala Gly Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr 
                165                 170                 175     


Gln Gln Leu Ala Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln 
            180                 185                 190         


Gln Gln His Leu Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln 
        195                 200                 205             


Pro Gly Gln Pro Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile 
    210                 215                 220                 


Pro Thr Glu Leu Gln Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr 
225                 230                 235                 240 


Ala Glu Glu Thr Thr Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr 
                245                 250                 255     


Thr Cys Val Ser Ser Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn 
            260                 265                 270         


Pro His Ala Ser Thr Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg 
        275                 280                 285             


Glu Ser Leu Ser His Glu Glu His Pro His Ser His Pro Leu Tyr Gly 
    290                 295                 300                 


His Gly Val Cys Lys Trp Pro Gly Cys Glu Ala Val Cys Glu Asp Phe 
305                 310                 315                 320 


Gln Ser Phe Leu Asn Leu Gln Lys Thr Lys Asn Ala Cys Lys Pro 
                325                 330                 335 


<210>  315
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  315

Met Gln Gln Leu Gln Gln Gln His Leu Leu Ser Leu Gln Arg Gln Gly 
1               5                   10                  15      


Leu Leu Thr Ile Gln Pro Gly Gln Pro Ala Leu Pro Leu Gln Pro Leu 
            20                  25                  30          


Ala Gln Gly Met Ile Pro Thr Glu Leu Gln Gln Leu Trp Lys Glu Val 
        35                  40                  45              


Thr Ser Ala His Thr Ala Glu Glu Thr Thr Gly Asn Asn His Ser Ser 
    50                  55                  60                  


Leu Asp Leu Thr Thr Thr Cys Val Ser Ser Ser Ala Pro Ser Lys Thr 
65                  70                  75                  80  


Ser Leu Ile Met Asn Pro His Ala Ser Thr Asn Gly Gln Leu Ser Val 
                85                  90                  95      


His Thr Pro Lys Arg Glu Ser Leu Ser His Glu Glu His Pro His Ser 
            100                 105                 110         


His Pro Leu Tyr Gly His Gly Val Cys Lys Trp Pro Gly Cys Glu Ala 
        115                 120                 125             


Val Cys Glu Asp Phe Gln Ser Phe Leu Lys His Leu Asn Ser Glu His 
    130                 135                 140                 


Ala Leu Asp Asp Arg Ser Thr Ala Gln Cys Arg Val Gln Met Gln Val 
145                 150                 155                 160 


Val Gln Gln Leu Glu Leu Gln Leu Ala Lys Asp Lys Glu Arg Leu Gln 
                165                 170                 175     


Ala Met Met Thr His Leu His Val Lys Ser Thr Glu Pro Lys Ala Ala 
            180                 185                 190         


Pro Gln Pro Leu Asn Leu Val Ser Ser Val Thr Leu Ser Lys Ser Ala 
        195                 200                 205             


Ser Glu Ala Ser Pro Gln Ser Leu Pro His Thr Pro Thr Thr Pro Thr 
    210                 215                 220                 


Ala Pro Leu Thr Pro Val Thr Gln Gly Pro Ser Val Ile Thr Thr Thr 
225                 230                 235                 240 


Ser Met His Thr Val Gly Pro Ile Arg Arg Arg Tyr Ser Asp Lys Tyr 
                245                 250                 255     


Asn Val Pro Ile Ser Ser Ala Asp Ile Ala Gln Asn Gln Glu Phe Tyr 
            260                 265                 270         


Lys Asn Ala Glu Val Arg Pro Pro Phe Thr Tyr Ala Ser Leu Ile Arg 
        275                 280                 285             


Gln Ala Ile Leu Glu Ser Pro Glu Lys Gln Leu Thr Leu Asn Glu Ile 
    290                 295                 300                 


Tyr Asn Trp Phe Thr Arg Met Phe Ala Tyr Phe Arg Arg Asn Ala Ala 
305                 310                 315                 320 


Thr Trp Lys Asn Ala Val Arg His Asn Leu Ser Leu His Lys Cys Phe 
                325                 330                 335     


Val Arg Val Glu Asn Val Lys Gly Ala Val Trp Thr Val Asp Glu Val 
            340                 345                 350         


Glu Phe Gln Lys Arg Arg Pro Gln Lys Ile Ser Gly Asn Pro Ser Leu 
        355                 360                 365             


Ile Lys Asn Met Gln Ser Ser His Ala Tyr Cys Thr Pro Leu Asn Ala 
    370                 375                 380                 


Ala Leu Gln Ala Ser Met Ala Glu Asn Ser Ile Pro Leu Tyr Thr Thr 
385                 390                 395                 400 


Ala Ser Met Gly Asn Pro Thr Leu Gly Asn Leu Ala Ser Ala Ile Arg 
                405                 410                 415     


Glu Glu Leu Asn Gly Ala Met Glu His Thr Asn Ser Asn Glu Ser Asp 
            420                 425                 430         


Ser Ser Pro Gly Arg Ser Pro Met Gln Ala Val His Pro Val His Val 
        435                 440                 445             


Lys Glu Glu Pro Leu Asp Pro Glu Glu Ala Glu Gly Pro Leu Ser Leu 
    450                 455                 460                 


Val Thr Thr Ala 
465             


<210>  316
<211>  679
<212>  PRT
<213>  Homo sapiens

<400>  316

Met Phe Gln Cys Val Phe Ser Ser Ser Val Leu Gln Pro His Ser Thr 
1               5                   10                  15      


Ser Cys Leu Phe Lys His Leu Phe Tyr His Ser Ala Thr Pro Ala Ser 
            20                  25                  30          


Gln Lys Gln Pro Glu Pro Ile Tyr Ser Lys Lys Thr Glu Ile Gln Arg 
        35                  40                  45              


Gln Thr Val Arg Ala Pro Phe Ala Lys Leu Phe Ile Phe Ser Ala Leu 
    50                  55                  60                  


Gln Val Ala Arg Gln Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln Val 
65                  70                  75                  80  


Ser Gly Leu Lys Ser Pro Lys Arg Asn Asp Lys Gln Pro Ala Leu Gln 
                85                  90                  95      


Val Pro Val Ser Val Ala Met Met Thr Pro Gln Val Ile Thr Pro Gln 
            100                 105                 110         


Gln Met Gln Gln Ile Leu Gln Gln Gln Val Leu Ser Pro Gln Gln Leu 
        115                 120                 125             


Gln Val Leu Leu Gln Gln Gln Gln Ala Leu Met Leu Gln Gln Gln Gln 
    130                 135                 140                 


Leu Gln Glu Phe Tyr Lys Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu 
145                 150                 155                 160 


Leu Gln Gln Gln His Ala Gly Lys Gln Pro Lys Glu Gln Gln Gln Val 
                165                 170                 175     


Ala Thr Gln Gln Leu Ala Phe Gln Gln Gln Leu Leu Gln Met Gln Gln 
            180                 185                 190         


Leu Gln Gln Gln His Leu Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr 
        195                 200                 205             


Ile Gln Pro Gly Gln Pro Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly 
    210                 215                 220                 


Met Ile Pro Thr Glu Leu Gln Gln Leu Trp Lys Glu Val Thr Ser Ala 
225                 230                 235                 240 


His Thr Ala Glu Glu Thr Thr Gly Asn Asn His Ser Ser Leu Asp Leu 
                245                 250                 255     


Thr Thr Thr Cys Val Ser Ser Ser Ala Pro Ser Lys Thr Ser Leu Ile 
            260                 265                 270         


Met Asn Pro His Ala Ser Thr Asn Gly Gln Leu Ser Val His Thr Pro 
        275                 280                 285             


Lys Arg Glu Ser Leu Ser His Glu Glu His Pro His Ser His Pro Leu 
    290                 295                 300                 


Tyr Gly His Gly Val Cys Lys Trp Pro Gly Cys Glu Ala Val Cys Glu 
305                 310                 315                 320 


Asp Phe Gln Ser Phe Leu Lys His Leu Asn Ser Glu His Ala Leu Asp 
                325                 330                 335     


Asp Arg Ser Thr Ala Gln Cys Arg Val Gln Met Gln Val Val Gln Gln 
            340                 345                 350         


Leu Glu Leu Gln Leu Ala Lys Asp Lys Glu Arg Leu Gln Ala Met Met 
        355                 360                 365             


Thr His Leu His Val Lys Ser Thr Glu Pro Lys Ala Ala Pro Gln Pro 
    370                 375                 380                 


Leu Asn Leu Val Ser Ser Val Thr Leu Ser Lys Ser Ala Ser Glu Ala 
385                 390                 395                 400 


Ser Pro Gln Ser Leu Pro His Thr Pro Thr Thr Pro Thr Ala Pro Leu 
                405                 410                 415     


Thr Pro Val Thr Gln Gly Pro Ser Val Ile Thr Thr Thr Ser Met His 
            420                 425                 430         


Thr Val Gly Pro Ile Arg Arg Arg Tyr Ser Asp Lys Tyr Asn Val Pro 
        435                 440                 445             


Ile Ser Ser Ala Asp Ile Ala Gln Asn Gln Glu Phe Tyr Lys Asn Ala 
    450                 455                 460                 


Glu Val Arg Pro Pro Phe Thr Tyr Ala Ser Leu Ile Arg Gln Ala Ile 
465                 470                 475                 480 


Leu Glu Ser Pro Glu Lys Gln Leu Thr Leu Asn Glu Ile Tyr Asn Trp 
                485                 490                 495     


Phe Thr Arg Met Phe Ala Tyr Phe Arg Arg Asn Ala Ala Thr Trp Lys 
            500                 505                 510         


Asn Ala Val Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val 
        515                 520                 525             


Glu Asn Val Lys Gly Ala Val Trp Thr Val Asp Glu Val Glu Phe Gln 
    530                 535                 540                 


Lys Arg Arg Pro Gln Lys Ile Ser Gly Asn Pro Ser Leu Ile Lys Asn 
545                 550                 555                 560 


Met Gln Ser Ser His Ala Tyr Cys Thr Pro Leu Asn Ala Ala Leu Gln 
                565                 570                 575     


Ala Ser Met Ala Glu Asn Ser Ile Pro Leu Tyr Thr Thr Ala Ser Met 
            580                 585                 590         


Gly Asn Pro Thr Leu Gly Asn Leu Ala Ser Ala Ile Arg Glu Glu Leu 
        595                 600                 605             


Asn Gly Ala Met Glu His Thr Asn Ser Asn Glu Ser Asp Ser Ser Pro 
    610                 615                 620                 


Gly Arg Ser Pro Met Gln Ala Val His Pro Val His Val Lys Glu Glu 
625                 630                 635                 640 


Pro Leu Asp Pro Glu Glu Ala Glu Gly Pro Leu Ser Leu Val Thr Thr 
                645                 650                 655     


Ala Asn His Ser Pro Asp Phe Asp His Asp Arg Asp Tyr Glu Asp Glu 
            660                 665                 670         


Pro Val Asn Glu Asp Met Glu 
        675                 


<210>  317
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  317

Met Leu Ala Leu Glu Ala Ala Gln Leu Asp Gly Pro His Phe Ser Cys 
1               5                   10                  15      


Leu Tyr Pro Asp Gly Val Phe Tyr Asp Leu Asp Ser Cys Lys His Ser 
            20                  25                  30          


Ser Tyr Pro Asp Ser Glu Gly Ala Pro Asp Ser Leu Trp Asp Trp Thr 
        35                  40                  45              


Val Ala Pro Pro Val Pro Ala Thr Pro Tyr Glu Ala Phe Asp Pro Ala 
    50                  55                  60                  


Ala Ala Ala Phe Ser His Pro Gln Ala Ala Gln Leu Cys Tyr Glu Pro 
65                  70                  75                  80  


Pro Thr Tyr Ser Pro Ala Gly Asn Leu Glu Leu Ala Pro Ser Leu Glu 
                85                  90                  95      


Ala Pro Gly Pro Gly Leu Pro Ala Tyr Pro Thr Glu Asn Phe Ala Ser 
            100                 105                 110         


Gln Thr Leu Val Pro Pro Ala Tyr Ala Pro Tyr Pro Ser Pro Val Leu 
        115                 120                 125             


Ser Glu Glu Glu Asp Leu Pro Leu Asp Ser Pro Ala Leu Glu Val Ser 
    130                 135                 140                 


Asp Ser Glu Ser Asp Glu Ala Leu Val Ala Gly Pro Glu Gly Lys Gly 
145                 150                 155                 160 


Ser Glu Gly Leu Ala Arg Ser Cys Ala Cys Thr Ser Ser Cys Trp Gly 
                165                 170                 175     


Tyr 
    


<210>  318
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  318

Met Ala Ser Ser Met Thr Trp Thr Ala Ala Ser Ile Pro Ala Thr Leu 
1               5                   10                  15      


Ile Gln Arg Gly Leu Leu Thr Leu Val Pro Pro Ala Tyr Ala Pro Tyr 
            20                  25                  30          


Pro Ser Pro Val Leu Ser Glu Glu Glu Asp Leu Pro Leu Asp Ser Pro 
        35                  40                  45              


Ala Leu Glu Val Ser Asp Ser Glu Ser Asp Glu Ala Leu Val Ala Gly 
    50                  55                  60                  


Pro Glu Gly Lys Gly Ser Glu Ala Gly Thr Arg Lys Lys Leu Arg Leu 
65                  70                  75                  80  


Tyr Gln Phe Leu Leu Gly Leu Leu Thr Arg Gly Asp Met Arg Glu Cys 
                85                  90                  95      


Val Trp Trp Val Glu Pro Gly Ala Gly Val Phe Gln Phe Ser Ser Lys 
            100                 105                 110         


His Lys Glu Leu Leu Ala Arg Arg Trp Gly Gln Gln Lys Gly Asn Arg 
        115                 120                 125             


Lys Arg Met Thr Tyr Gln Lys Leu Ala Arg Ala Leu Arg Asn Tyr Ala 
    130                 135                 140                 


Lys Thr Gly Glu Ile Arg Lys Val Lys Arg Lys Leu Thr Tyr Gln Phe 
145                 150                 155                 160 


Asp Ser Ala Leu Leu Pro Ala Val Arg Arg Ala 
                165                 170     


<210>  319
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  319

Met Leu Ala Leu Glu Ala Ala Gln Phe Arg Trp Leu Glu Ala Ala Ser 
1               5                   10                  15      


Ala Cys Pro Cys Val Ser Pro Pro Pro Gly Ser Thr Gly His Thr Ser 
            20                  25                  30          


Ala Val Cys Thr Gln Met Ala Ser Ser Met Thr Trp Thr Ala Ala Ser 
        35                  40                  45              


Ile Pro Ala Thr Leu Ile Gln Arg Gly Leu Leu Thr Pro Cys Gly Thr 
    50                  55                  60                  


Gly Leu Trp Pro His Leu Ser Gln Pro Pro Pro Met Lys Pro Ser Thr 
65                  70                  75                  80  


Arg Gln Gln Pro Leu Leu Ala Thr Pro Arg Leu Pro Ser Ser Ala Thr 
                85                  90                  95      


Asn Pro Pro Pro Thr Ala Leu Gln Gly Thr Ser Asn Trp Pro Pro Ala 
            100                 105                 110         


Trp Arg Pro Arg Gly Leu Ala Ser Leu His Thr Pro Arg Arg Thr 
        115                 120                 125         


<210>  320
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  320

Met Leu Ala Leu Glu Ala Ala Gln Leu Asp Gly Pro His Phe Ser Cys 
1               5                   10                  15      


Leu Tyr Pro Asp Gly Val Phe Tyr Asp Leu Asp Ser Cys Lys His Ser 
            20                  25                  30          


Ser Tyr Pro Asp Ser Glu Gly Ala Pro Asp Pro Gly Ser Pro Gly Ile 
        35                  40                  45              


Cys Pro Val Pro Gln Pro Cys Ala Ile Arg Gly Gly Arg Leu Thr Val 
    50                  55                  60                  


Gly Gln Pro Cys Pro Gly Gly Leu Gly Gln Arg Val Gly 
65                  70                  75          


<210>  321
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  321

Met Leu Ala Leu Glu Ala Ala Gln Leu Asp Gly Pro His Phe Ser Cys 
1               5                   10                  15      


Leu Tyr Pro Asp Gly Val Phe Tyr Asp Leu Asp Ser Cys Lys His Ser 
            20                  25                  30          


Ser Tyr Pro Asp Ser Glu Gly Ala Pro Asp Ser Leu Trp Asp Trp Thr 
        35                  40                  45              


Val Ala Pro Pro Val Pro Ala Thr Pro Tyr Glu Ala Phe Asp Pro Ala 
    50                  55                  60                  


Ala Ala Ala Phe Ser His Pro Gln Ala Ala Gln Leu Cys Tyr Glu Pro 
65                  70                  75                  80  


Pro Thr Tyr Ser Pro Ala Gly Asn Leu Glu Leu Ala Pro Ser Leu Glu 
                85                  90                  95      


Ala Pro Gly Pro Gly Leu Pro Ala Tyr Pro Thr Glu Asn Phe Ala Ser 
            100                 105                 110         


Gln Thr Leu Val Pro Pro Ala Tyr Ala Pro Tyr Pro Ser Pro Val Leu 
        115                 120                 125             


Ser Glu Glu Glu Asp Leu Pro Leu Asp Ser Pro Ala Leu Glu Val Ser 
    130                 135                 140                 


Asp Ser Glu Ser Asp Glu Ala Leu Val Ala Gly Pro Glu Gly Lys Gly 
145                 150                 155                 160 


Ser Glu Ala Gly Thr Arg Lys Lys Leu Arg Leu Tyr Gln Phe Leu Leu 
                165                 170                 175     


Gly Leu Leu Thr Arg Gly Asp Met Arg Glu Cys Val Trp Trp Val Glu 
            180                 185                 190         


Pro Gly Ala Gly Val Phe Gln Phe Ser Ser Lys His Lys Glu Leu Leu 
        195                 200                 205             


Ala Arg Arg Trp Gly Gln Gln Lys Gly Asn Arg Lys Arg Met Thr Tyr 
    210                 215                 220                 


Gln Lys Leu Ala Arg Ala Leu Arg Asn Tyr Ala Lys Thr Gly Glu Ile 
225                 230                 235                 240 


Arg Lys Val Lys Arg Lys Leu Thr Tyr Gln Phe Asp Ser Ala Leu Leu 
                245                 250                 255     


Pro Ala Val Arg Arg Ala 
            260         


<210>  322
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  322

Met Leu Ala Leu Glu Ala Ala Gln Leu Asp Gly Pro His Phe Ser Cys 
1               5                   10                  15      


Leu Tyr Pro Asp Gly Val Phe Tyr Asp Leu Asp Ser Cys Lys His Ser 
            20                  25                  30          


Ser Tyr Pro Asp Ser Glu Gly Ala Pro Asp Ser Leu Trp Asp Trp Thr 
        35                  40                  45              


Val Ala Pro Pro Val Pro Ala Thr Pro Tyr Glu Ala Phe Asp Pro Ala 
    50                  55                  60                  


Ala Ala Ala Phe Ser His Pro Gln Ala Ala Gln Leu Cys Tyr Glu Pro 
65                  70                  75                  80  


Pro Thr Tyr Ser Pro Ala Gly Asn Leu Glu Leu Ala Pro Ser Leu Glu 
                85                  90                  95      


Ala Pro Gly Pro Gly Leu Pro Ala Tyr Pro Thr Glu Asn Phe Ala Ser 
            100                 105                 110         


Gln Pro Cys Ala Ile Arg Gly Gly Arg Leu Thr Val Gly Gln Pro Cys 
        115                 120                 125             


Pro Gly Gly Leu Gly Gln Arg Val Gly 
    130                 135         


<210>  323
<211>  1226
<212>  PRT
<213>  Homo sapiens

<400>  323

Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp Asp Leu Glu Ser 
1               5                   10                  15      


Leu Cys Val Tyr Glu Pro Asp Arg Asn Ala Leu Arg Arg Lys Glu Arg 
            20                  25                  30          


Glu Arg Arg Asn Gln Glu Thr Gln Gln Asp Asp Gly Thr Phe Asn Ser 
        35                  40                  45              


Ser Tyr Ser Leu Phe Ser Glu Pro Tyr Lys Thr Asn Lys Gly Asp Glu 
    50                  55                  60                  


Leu Ser Asn Arg Ile Gln Asn Thr Leu Gly Asn Tyr Asp Glu Met Lys 
65                  70                  75                  80  


Asp Phe Leu Thr Asp Arg Ser Asn Gln Ser His Leu Val Gly Val Pro 
                85                  90                  95      


Lys Pro Gly Val Pro Gln Thr Pro Val Asn Lys Ile Asp Glu His Phe 
            100                 105                 110         


Val Ala Asp Ser Arg Ala Gln Asn Gln Pro Ser Ser Ile Cys Ser Thr 
        115                 120                 125             


Thr Thr Ser Thr Pro Ala Ala Val Pro Val Gln Gln Ser Lys Arg Gly 
    130                 135                 140                 


Thr Met Gly Trp Gln Lys Ala Gly His Pro Pro Ser Asp Gly Gln Gln 
145                 150                 155                 160 


Arg Ala Thr Gln Gln Gly Ser Leu Arg Thr Leu Leu Gly Asp Gly Val 
                165                 170                 175     


Gly Arg Gln Gln Pro Arg Ala Lys Gln Val Cys Asn Val Glu Val Gly 
            180                 185                 190         


Leu Gln Thr Gln Glu Arg Pro Pro Ala Met Ala Ala Lys His Ser Ser 
        195                 200                 205             


Ser Gly His Cys Val Gln Asn Phe Pro Pro Ser Leu Ala Ser Lys Pro 
    210                 215                 220                 


Ser Leu Val Gln Gln Lys Pro Thr Ala Tyr Val Arg Pro Met Asp Gly 
225                 230                 235                 240 


Gln Asp Gln Ala Pro Asp Glu Ser Pro Lys Leu Lys Ser Ser Ser Glu 
                245                 250                 255     


Thr Ser Val His Cys Thr Ser Tyr Arg Gly Val Pro Ala Ser Lys Pro 
            260                 265                 270         


Glu Pro Ala Arg Ala Lys Ala Lys Leu Ser Lys Phe Ser Ile Pro Lys 
        275                 280                 285             


Gln Gly Glu Glu Ser Arg Ser Gly Glu Thr Asn Ser Cys Val Glu Glu 
    290                 295                 300                 


Ile Ile Arg Glu Met Thr Trp Leu Pro Pro Leu Ser Ala Ile Gln Ala 
305                 310                 315                 320 


Pro Gly Lys Val Glu Pro Thr Lys Phe Pro Phe Pro Asn Lys Asp Ser 
                325                 330                 335     


Gln Leu Val Ser Ser Gly His Asn Asn Pro Lys Lys Gly Asp Ala Glu 
            340                 345                 350         


Pro Glu Ser Pro Asp Asn Gly Thr Ser Asn Thr Ser Met Leu Glu Asp 
        355                 360                 365             


Asp Leu Lys Leu Ser Ser Asp Glu Glu Glu Asn Glu Gln Gln Ala Ala 
    370                 375                 380                 


Gln Arg Thr Ala Leu Arg Ala Leu Ser Asp Ser Ala Val Val Gln Gln 
385                 390                 395                 400 


Pro Asn Cys Arg Thr Ser Val Pro Ser Ser Lys Gly Ser Ser Ser Ser 
                405                 410                 415     


Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Asp Ser Glu Ser Ser Ser 
            420                 425                 430         


Gly Ser Asp Ser Glu Thr Glu Ser Ser Ser Ser Glu Ser Glu Gly Ser 
        435                 440                 445             


Lys Pro Pro His Phe Ser Ser Pro Glu Ala Glu Pro Ala Ser Ser Asn 
    450                 455                 460                 


Lys Trp Gln Leu Asp Lys Trp Leu Asn Lys Val Asn Pro His Lys Pro 
465                 470                 475                 480 


Pro Ile Leu Ile Gln Asn Glu Ser His Gly Ser Glu Ser Asn Gln Tyr 
                485                 490                 495     


Tyr Asn Pro Val Lys Glu Asp Val Gln Asp Cys Gly Lys Val Pro Asp 
            500                 505                 510         


Val Cys Gln Pro Ser Leu Arg Glu Lys Glu Ile Lys Ser Thr Cys Lys 
        515                 520                 525             


Glu Glu Gln Arg Pro Arg Thr Ala Asn Lys Ala Pro Gly Ser Lys Gly 
    530                 535                 540                 


Val Lys Gln Lys Ser Pro Pro Ala Ala Val Ala Val Ala Val Ser Ala 
545                 550                 555                 560 


Ala Ala Pro Pro Pro Ala Val Pro Cys Ala Pro Ala Glu Asn Ala Pro 
                565                 570                 575     


Ala Pro Ala Arg Arg Ser Ala Gly Lys Lys Pro Thr Arg Arg Thr Glu 
            580                 585                 590         


Arg Thr Ser Ala Gly Asp Gly Ala Asn Cys His Arg Pro Glu Glu Pro 
        595                 600                 605             


Ala Ala Ala Asp Ala Leu Gly Thr Ser Val Val Val Pro Pro Glu Pro 
    610                 615                 620                 


Thr Lys Thr Arg Pro Cys Gly Asn Asn Arg Ala Ser His Arg Lys Glu 
625                 630                 635                 640 


Leu Arg Ser Ser Val Thr Cys Glu Lys Arg Arg Thr Arg Gly Leu Ser 
                645                 650                 655     


Arg Ile Val Pro Lys Ser Lys Glu Phe Ile Glu Thr Glu Ser Ser Ser 
            660                 665                 670         


Ser Ser Ser Ser Ser Asp Ser Asp Leu Glu Ser Glu Gln Glu Glu Tyr 
        675                 680                 685             


Pro Leu Ser Lys Ala Gln Thr Val Ala Ala Ser Ala Ser Ser Gly Asn 
    690                 695                 700                 


Asp Gln Arg Leu Lys Glu Ala Ala Ala Asn Gly Gly Ser Gly Pro Arg 
705                 710                 715                 720 


Ala Pro Val Gly Ser Ile Asn Ala Arg Thr Thr Ser Asp Ile Ala Lys 
                725                 730                 735     


Glu Leu Glu Glu Gln Phe Tyr Thr Leu Val Pro Phe Gly Arg Asn Glu 
            740                 745                 750         


Leu Leu Ser Pro Leu Lys Asp Ser Asp Glu Ile Arg Ser Leu Trp Val 
        755                 760                 765             


Lys Ile Asp Leu Thr Leu Leu Ser Arg Ile Pro Glu His Leu Pro Gln 
    770                 775                 780                 


Glu Pro Gly Val Leu Ser Ala Pro Ala Thr Lys Asp Ser Glu Ser Ala 
785                 790                 795                 800 


Pro Pro Ser His Thr Ser Asp Thr Pro Ala Glu Lys Ala Leu Pro Lys 
                805                 810                 815     


Ser Lys Arg Lys Arg Lys Cys Asp Asn Glu Asp Asp Tyr Arg Glu Ile 
            820                 825                 830         


Lys Lys Ser Gln Gly Glu Lys Asp Ser Ser Ser Arg Leu Ala Thr Ser 
        835                 840                 845             


Thr Ser Asn Thr Leu Ser Ala Asn His Cys Asn Met Asn Ile Asn Ser 
    850                 855                 860                 


Val Ala Ile Pro Ile Asn Lys Asn Glu Lys Met Leu Arg Ser Pro Ile 
865                 870                 875                 880 


Ser Pro Leu Ser Asp Ala Ser Lys His Lys Tyr Thr Ser Glu Asp Leu 
                885                 890                 895     


Thr Ser Ser Ser Arg Pro Asn Gly Asn Ser Leu Phe Thr Ser Ala Ser 
            900                 905                 910         


Ser Ser Lys Lys Pro Lys Ala Asp Ser Gln Leu Gln Pro His Gly Gly 
        915                 920                 925             


Asp Leu Thr Lys Ala Ala His Asn Asn Ser Glu Asn Ile Pro Leu His 
    930                 935                 940                 


Lys Ser Arg Pro Gln Thr Lys Pro Trp Ser Pro Gly Ser Asn Gly His 
945                 950                 955                 960 


Arg Asp Cys Lys Arg Gln Lys Leu Val Phe Asp Asp Met Pro Arg Ser 
                965                 970                 975     


Ala Asp Tyr Phe Met Gln Glu Ala Lys Arg Met Lys His Lys Ala Asp 
            980                 985                 990         


Ala Met Val Glu Lys Phe Gly Lys  Ala Leu Asn Tyr Ala  Glu Ala Ala 
        995                 1000                 1005             


Leu Ser  Phe Ile Glu Cys Gly  Asn Ala Met Glu Gln  Gly Pro Met 
    1010                 1015                 1020             


Glu Ser  Lys Ser Pro Tyr Thr  Met Tyr Ser Glu Thr  Val Glu Leu 
    1025                 1030                 1035             


Ile Arg  Tyr Ala Met Arg Leu  Lys Thr His Ser Gly  Pro Asn Ala 
    1040                 1045                 1050             


Thr Pro  Glu Asp Lys Gln Leu  Ala Ala Leu Cys Tyr  Arg Cys Leu 
    1055                 1060                 1065             


Ala Leu  Leu Tyr Trp Arg Met  Phe Arg Leu Lys Arg  Asp His Ala 
    1070                 1075                 1080             


Val Lys  Tyr Ser Lys Ala Leu  Ile Asp Tyr Phe Lys  Asn Ser Ser 
    1085                 1090                 1095             


Lys Ala  Ala Gln Ala Pro Ser  Pro Trp Gly Ala Ser  Gly Lys Ser 
    1100                 1105                 1110             


Thr Gly  Thr Pro Ser Pro Met  Ser Pro Asn Pro Ser  Pro Ala Ser 
    1115                 1120                 1125             


Ser Val  Gly Ser Gln Gly Ser  Leu Ser Asn Ala Ser  Ala Leu Ser 
    1130                 1135                 1140             


Pro Ser  Thr Ile Val Ser Ile  Pro Gln Arg Ile His  Gln Met Ala 
    1145                 1150                 1155             


Ala Asn  His Val Ser Ile Thr  Asn Ser Ile Leu His  Ser Tyr Asp 
    1160                 1165                 1170             


Tyr Trp  Glu Met Ala Asp Asn  Leu Ala Lys Glu Asn  Arg Glu Phe 
    1175                 1180                 1185             


Phe Asn  Asp Leu Asp Leu Leu  Met Gly Pro Val Thr  Leu His Ser 
    1190                 1195                 1200             


Ser Met  Glu His Leu Val Gln  Tyr Ser Gln Gln Gly  Leu His Trp 
    1205                 1210                 1215             


Leu Arg  Asn Ser Ala His Leu  Ser 
    1220                 1225     


<210>  324
<211>  1251
<212>  PRT
<213>  Homo sapiens

<400>  324

Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp Asp Leu Glu Ser 
1               5                   10                  15      


Leu Trp Gly Glu Asp Ile Leu Asn Gln Arg Asn Asp Ser Leu Val Val 
            20                  25                  30          


Glu Phe Gln Ser Ser Ala Ser Arg Cys Arg Ser Val Tyr Glu Pro Asp 
        35                  40                  45              


Arg Asn Ala Leu Arg Arg Lys Glu Arg Glu Arg Arg Asn Gln Glu Thr 
    50                  55                  60                  


Gln Gln Asp Asp Gly Thr Phe Asn Ser Ser Tyr Ser Leu Phe Ser Glu 
65                  70                  75                  80  


Pro Tyr Lys Thr Asn Lys Gly Asp Glu Leu Ser Asn Arg Ile Gln Asn 
                85                  90                  95      


Thr Leu Gly Asn Tyr Asp Glu Met Lys Asp Phe Leu Thr Asp Arg Ser 
            100                 105                 110         


Asn Gln Ser His Leu Val Gly Val Pro Lys Pro Gly Val Pro Gln Thr 
        115                 120                 125             


Pro Val Asn Lys Ile Asp Glu His Phe Val Ala Asp Ser Arg Ala Gln 
    130                 135                 140                 


Asn Gln Pro Ser Ser Ile Cys Ser Thr Thr Thr Ser Thr Pro Ala Ala 
145                 150                 155                 160 


Val Pro Val Gln Gln Ser Lys Arg Gly Thr Met Gly Trp Gln Lys Ala 
                165                 170                 175     


Gly His Pro Pro Ser Asp Gly Gln Gln Arg Ala Thr Gln Gln Gly Ser 
            180                 185                 190         


Leu Arg Thr Leu Leu Gly Asp Gly Val Gly Arg Gln Gln Pro Arg Ala 
        195                 200                 205             


Lys Gln Val Cys Asn Val Glu Val Gly Leu Gln Thr Gln Glu Arg Pro 
    210                 215                 220                 


Pro Ala Met Ala Ala Lys His Ser Ser Ser Gly His Cys Val Gln Asn 
225                 230                 235                 240 


Phe Pro Pro Ser Leu Ala Ser Lys Pro Ser Leu Val Gln Gln Lys Pro 
                245                 250                 255     


Thr Ala Tyr Val Arg Pro Met Asp Gly Gln Asp Gln Ala Pro Asp Glu 
            260                 265                 270         


Ser Pro Lys Leu Lys Ser Ser Ser Glu Thr Ser Val His Cys Thr Ser 
        275                 280                 285             


Tyr Arg Gly Val Pro Ala Ser Lys Pro Glu Pro Ala Arg Ala Lys Ala 
    290                 295                 300                 


Lys Leu Ser Lys Phe Ser Ile Pro Lys Gln Gly Glu Glu Ser Arg Ser 
305                 310                 315                 320 


Gly Glu Thr Asn Ser Cys Val Glu Glu Ile Ile Arg Glu Met Thr Trp 
                325                 330                 335     


Leu Pro Pro Leu Ser Ala Ile Gln Ala Pro Gly Lys Val Glu Pro Thr 
            340                 345                 350         


Lys Phe Pro Phe Pro Asn Lys Asp Ser Gln Leu Val Ser Ser Gly His 
        355                 360                 365             


Asn Asn Pro Lys Lys Gly Asp Ala Glu Pro Glu Ser Pro Asp Asn Gly 
    370                 375                 380                 


Thr Ser Asn Thr Ser Met Leu Glu Asp Asp Leu Lys Leu Ser Ser Asp 
385                 390                 395                 400 


Glu Glu Glu Asn Glu Gln Gln Ala Ala Gln Arg Thr Ala Leu Arg Ala 
                405                 410                 415     


Leu Ser Asp Ser Ala Val Val Gln Gln Pro Asn Cys Arg Thr Ser Val 
            420                 425                 430         


Pro Ser Ser Lys Gly Ser Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser 
        435                 440                 445             


Ser Ser Ser Asp Ser Glu Ser Ser Ser Gly Ser Asp Ser Glu Thr Glu 
    450                 455                 460                 


Ser Ser Ser Ser Glu Ser Glu Gly Ser Lys Pro Pro His Phe Ser Ser 
465                 470                 475                 480 


Pro Glu Ala Glu Pro Ala Ser Ser Asn Lys Trp Gln Leu Asp Lys Trp 
                485                 490                 495     


Leu Asn Lys Val Asn Pro His Lys Pro Pro Ile Leu Ile Gln Asn Glu 
            500                 505                 510         


Ser His Gly Ser Glu Ser Asn Gln Tyr Tyr Asn Pro Val Lys Glu Asp 
        515                 520                 525             


Val Gln Asp Cys Gly Lys Val Pro Asp Val Cys Gln Pro Ser Leu Arg 
    530                 535                 540                 


Glu Lys Glu Ile Lys Ser Thr Cys Lys Glu Glu Gln Arg Pro Arg Thr 
545                 550                 555                 560 


Ala Asn Lys Ala Pro Gly Ser Lys Gly Val Lys Gln Lys Ser Pro Pro 
                565                 570                 575     


Ala Ala Val Ala Val Ala Val Ser Ala Ala Ala Pro Pro Pro Ala Val 
            580                 585                 590         


Pro Cys Ala Pro Ala Glu Asn Ala Pro Ala Pro Ala Arg Arg Ser Ala 
        595                 600                 605             


Gly Lys Lys Pro Thr Arg Arg Thr Glu Arg Thr Ser Ala Gly Asp Gly 
    610                 615                 620                 


Ala Asn Cys His Arg Pro Glu Glu Pro Ala Ala Ala Asp Ala Leu Gly 
625                 630                 635                 640 


Thr Ser Val Val Val Pro Pro Glu Pro Thr Lys Thr Arg Pro Cys Gly 
                645                 650                 655     


Asn Asn Arg Ala Ser His Arg Lys Glu Leu Arg Ser Ser Val Thr Cys 
            660                 665                 670         


Glu Lys Arg Arg Thr Arg Gly Leu Ser Arg Ile Val Pro Lys Ser Lys 
        675                 680                 685             


Glu Phe Ile Glu Thr Glu Ser Ser Ser Ser Ser Ser Ser Ser Asp Ser 
    690                 695                 700                 


Asp Leu Glu Ser Glu Gln Glu Glu Tyr Pro Leu Ser Lys Ala Gln Thr 
705                 710                 715                 720 


Val Ala Ala Ser Ala Ser Ser Gly Asn Asp Gln Arg Leu Lys Glu Ala 
                725                 730                 735     


Ala Ala Asn Gly Gly Ser Gly Pro Arg Ala Pro Val Gly Ser Ile Asn 
            740                 745                 750         


Ala Arg Thr Thr Ser Asp Ile Ala Lys Glu Leu Glu Glu Gln Phe Tyr 
        755                 760                 765             


Thr Leu Val Pro Phe Gly Arg Asn Glu Leu Leu Ser Pro Leu Lys Asp 
    770                 775                 780                 


Ser Asp Glu Ile Arg Ser Leu Trp Val Lys Ile Asp Leu Thr Leu Leu 
785                 790                 795                 800 


Ser Arg Ile Pro Glu His Leu Pro Gln Glu Pro Gly Val Leu Ser Ala 
                805                 810                 815     


Pro Ala Thr Lys Asp Ser Glu Ser Ala Pro Pro Ser His Thr Ser Asp 
            820                 825                 830         


Thr Pro Ala Glu Lys Ala Leu Pro Lys Ser Lys Arg Lys Arg Lys Cys 
        835                 840                 845             


Asp Asn Glu Asp Asp Tyr Arg Glu Ile Lys Lys Ser Gln Gly Glu Lys 
    850                 855                 860                 


Asp Ser Ser Ser Arg Leu Ala Thr Ser Thr Ser Asn Thr Leu Ser Ala 
865                 870                 875                 880 


Asn His Cys Asn Met Asn Ile Asn Ser Val Ala Ile Pro Ile Asn Lys 
                885                 890                 895     


Asn Glu Lys Met Leu Arg Ser Pro Ile Ser Pro Leu Ser Asp Ala Ser 
            900                 905                 910         


Lys His Lys Tyr Thr Ser Glu Asp Leu Thr Ser Ser Ser Arg Pro Asn 
        915                 920                 925             


Gly Asn Ser Leu Phe Thr Ser Ala Ser Ser Ser Lys Lys Pro Lys Ala 
    930                 935                 940                 


Asp Ser Gln Leu Gln Pro His Gly Gly Asp Leu Thr Lys Ala Ala His 
945                 950                 955                 960 


Asn Asn Ser Glu Asn Ile Pro Leu His Lys Ser Arg Pro Gln Thr Lys 
                965                 970                 975     


Pro Trp Ser Pro Gly Ser Asn Gly His Arg Asp Cys Lys Arg Gln Lys 
            980                 985                 990         


Leu Val Phe Asp Asp Met Pro Arg  Ser Ala Asp Tyr Phe  Met Gln Glu 
        995                 1000                 1005             


Ala Lys  Arg Met Lys His Lys  Ala Asp Ala Met Val  Glu Lys Phe 
    1010                 1015                 1020             


Gly Lys  Ala Leu Asn Tyr Ala  Glu Ala Ala Leu Ser  Phe Ile Glu 
    1025                 1030                 1035             


Cys Gly  Asn Ala Met Glu Gln  Gly Pro Met Glu Ser  Lys Ser Pro 
    1040                 1045                 1050             


Tyr Thr  Met Tyr Ser Glu Thr  Val Glu Leu Ile Arg  Tyr Ala Met 
    1055                 1060                 1065             


Arg Leu  Lys Thr His Ser Gly  Pro Asn Ala Thr Pro  Glu Asp Lys 
    1070                 1075                 1080             


Gln Leu  Ala Ala Leu Cys Tyr  Arg Cys Leu Ala Leu  Leu Tyr Trp 
    1085                 1090                 1095             


Arg Met  Phe Arg Leu Lys Arg  Asp His Ala Val Lys  Tyr Ser Lys 
    1100                 1105                 1110             


Ala Leu  Ile Asp Tyr Phe Lys  Asn Ser Ser Lys Ala  Ala Gln Ala 
    1115                 1120                 1125             


Pro Ser  Pro Trp Gly Ala Ser  Gly Lys Ser Thr Gly  Thr Pro Ser 
    1130                 1135                 1140             


Pro Met  Ser Pro Asn Pro Ser  Pro Ala Ser Ser Val  Gly Ser Gln 
    1145                 1150                 1155             


Gly Ser  Leu Ser Asn Ala Ser  Ala Leu Ser Pro Ser  Thr Ile Val 
    1160                 1165                 1170             


Ser Ile  Pro Gln Arg Ile His  Gln Met Ala Ala Asn  His Val Ser 
    1175                 1180                 1185             


Ile Thr  Asn Ser Ile Leu His  Ser Tyr Asp Tyr Trp  Glu Met Ala 
    1190                 1195                 1200             


Asp Asn  Leu Ala Lys Glu Asn  Arg Glu Phe Phe Asn  Asp Leu Asp 
    1205                 1210                 1215             


Leu Leu  Met Gly Pro Val Thr  Leu His Ser Ser Met  Glu His Leu 
    1220                 1225                 1230             


Val Gln  Tyr Ser Gln Gln Gly  Leu His Trp Leu Arg  Asn Ser Ala 
    1235                 1240                 1245             


His Leu  Ser 
    1250     


<210>  325
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  325

Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp Asp Leu Glu Ser 
1               5                   10                  15      


Leu 
    


<210>  326
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  326

Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp Asp Leu Glu Ser 
1               5                   10                  15      


Leu Trp Gly Glu Asp Ile Leu Asn Gln Arg Asn Asp Ser Leu Val Val 
            20                  25                  30          


Glu Phe Gln Ser Ser Ala Ser Arg Cys Arg Ser Val Tyr Glu Pro Asp 
        35                  40                  45              


Arg Asn Ala Leu Arg Arg Lys Glu Arg Glu Arg Arg Asn Gln Glu Thr 
    50                  55                  60                  


Gln Gln Asp Asp Gly Thr Phe Asn Ser Ser Tyr Ser Leu Phe Ser Glu 
65                  70                  75                  80  


Pro Tyr Lys Thr Asn Lys Gly Asp Glu Leu Ser Asn Arg Ile Gln Asn 
                85                  90                  95      


Thr Leu Gly Asn Tyr Asp Glu Met Lys Asp Phe Leu Thr Asp Arg Ser 
            100                 105                 110         


Asn Gln Ser His Leu Val Gly Val Pro Lys Pro Gly Val Pro Gln Thr 
        115                 120                 125             


Pro Val Asn Lys Ile Asp Glu His Phe Val Ala Asp Ser Arg Ala Gln 
    130                 135                 140                 


Asn Gln Pro Ser Ser Ile Cys Ser Thr Thr Thr Ser Thr Pro Ala Ala 
145                 150                 155                 160 


Val Pro Val Gln Gln 
                165 


<210>  327
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  327

Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp Asp Leu Glu Ser 
1               5                   10                  15      


Leu Cys Val Tyr Glu Pro Asp Arg Asn Ala Leu Arg Arg Lys Glu Arg 
            20                  25                  30          


Glu Arg Arg Asn Gln Glu Thr Gln Gln Asp Asp Gly Thr Phe Asn Ser 
        35                  40                  45              


Ser Tyr Ser Leu Phe Ser Glu Pro Tyr Lys Thr Asn Lys Gly Asp Glu 
    50                  55                  60                  


Leu Ser Asn Arg Ile Gln Asn Thr Leu Gly Asn Tyr Asp Glu Met Lys 
65                  70                  75                  80  


Asp Phe Leu Thr Asp Arg Ser Asn Gln Ser His Leu Val Gly Val Pro 
                85                  90                  95      


Lys Pro Gly Val Pro Gln Thr Pro Val Asn Lys Ile Asp Glu His Phe 
            100                 105                 110         


Val Ala Asp Ser Arg Ala Gln Asn Gln Pro Ser Ser Ile Cys Ser Thr 
        115                 120                 125             


Thr 
    


<210>  328
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  328

Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp Asp Leu Glu Ser 
1               5                   10                  15      


Leu Cys Val Tyr Glu Pro Asp Arg Asn Ala Leu Arg Arg Lys Glu Arg 
            20                  25                  30          


Glu Arg Arg Asn Gln Glu Thr Gln Gln Asp Asp Gly Thr Phe Asn Ser 
        35                  40                  45              


Ser Tyr Ser Leu Phe Ser Glu Pro Tyr Lys Thr Asn Lys Gly Asp Glu 
    50                  55                  60                  


Leu Ser Asn Arg Ile Gln Asn Thr Leu Gly Asn Tyr Asp Glu Met Lys 
65                  70                  75                  80  


Asp Phe Leu Thr Asp Arg Ser Asn Gln Ser His Leu Val Gly Val Pro 
                85                  90                  95      


Lys Pro Gly 
            


<210>  329
<211>  580
<212>  PRT
<213>  Homo sapiens

<400>  329

Gly Asn Asn Arg Ala Ser His Arg Lys Glu Leu Arg Ser Ser Val Thr 
1               5                   10                  15      


Cys Glu Lys Arg Arg Thr Arg Gly Leu Ser Arg Ile Val Pro Lys Ser 
            20                  25                  30          


Lys Glu Phe Ile Glu Thr Glu Ser Ser Ser Ser Ser Ser Ser Ser Asp 
        35                  40                  45              


Ser Asp Leu Glu Ser Glu Gln Glu Glu Tyr Pro Leu Ser Lys Ala Gln 
    50                  55                  60                  


Thr Val Ala Ala Ser Ala Ser Ser Gly Asn Asp Gln Arg Leu Lys Glu 
65                  70                  75                  80  


Ala Ala Ala Asn Gly Gly Ser Gly Pro Arg Ala Pro Val Gly Ser Ile 
                85                  90                  95      


Asn Ala Arg Thr Thr Ser Asp Ile Ala Lys Glu Leu Glu Glu Gln Phe 
            100                 105                 110         


Tyr Thr Leu Val Pro Phe Gly Arg Asn Glu Leu Leu Ser Pro Leu Lys 
        115                 120                 125             


Asp Ser Asp Glu Ile Arg Ser Leu Trp Val Lys Ile Asp Leu Thr Leu 
    130                 135                 140                 


Leu Ser Arg Ile Pro Glu His Leu Pro Gln Glu Pro Gly Val Leu Ser 
145                 150                 155                 160 


Ala Pro Ala Thr Lys Asp Ser Glu Ser Ala Pro Pro Ser His Thr Ser 
                165                 170                 175     


Asp Thr Pro Ala Glu Lys Ala Leu Pro Lys Ser Lys Arg Lys Arg Lys 
            180                 185                 190         


Cys Asp Asn Glu Asp Asp Tyr Arg Glu Ile Lys Lys Ser Gln Gly Glu 
        195                 200                 205             


Lys Asp Ser Ser Ser Arg Leu Ala Thr Ser Thr Ser Asn Thr Leu Ser 
    210                 215                 220                 


Ala Asn His Cys Asn Met Asn Ile Asn Ser Val Ala Ile Pro Ile Asn 
225                 230                 235                 240 


Lys Asn Glu Lys Met Leu Arg Ser Pro Ile Ser Pro Leu Ser Asp Ala 
                245                 250                 255     


Ser Lys His Lys Tyr Thr Ser Glu Asp Leu Thr Ser Ser Ser Arg Pro 
            260                 265                 270         


Asn Gly Asn Ser Leu Phe Thr Ser Ala Ser Ser Ser Lys Lys Pro Lys 
        275                 280                 285             


Ala Asp Ser Gln Leu Gln Pro His Gly Gly Asp Leu Thr Lys Ala Ala 
    290                 295                 300                 


His Asn Asn Ser Glu Asn Ile Pro Leu His Lys Ser Arg Pro Gln Thr 
305                 310                 315                 320 


Lys Pro Trp Ser Pro Gly Ser Asn Gly His Arg Asp Cys Lys Arg Gln 
                325                 330                 335     


Lys Leu Val Phe Asp Asp Met Pro Arg Ser Ala Asp Tyr Phe Met Gln 
            340                 345                 350         


Glu Ala Lys Arg Met Lys His Lys Ala Asp Ala Met Val Glu Lys Phe 
        355                 360                 365             


Gly Lys Ala Leu Asn Tyr Ala Glu Ala Ala Leu Ser Phe Ile Glu Cys 
    370                 375                 380                 


Gly Asn Ala Met Glu Gln Gly Pro Met Glu Ser Lys Ser Pro Tyr Thr 
385                 390                 395                 400 


Met Tyr Ser Glu Thr Val Glu Leu Ile Arg Tyr Ala Met Arg Leu Lys 
                405                 410                 415     


Thr His Ser Gly Pro Asn Ala Thr Pro Glu Asp Lys Gln Leu Ala Ala 
            420                 425                 430         


Leu Cys Tyr Arg Cys Leu Ala Leu Leu Tyr Trp Arg Met Phe Arg Leu 
        435                 440                 445             


Lys Arg Asp His Ala Val Lys Tyr Ser Lys Ala Leu Ile Asp Tyr Phe 
    450                 455                 460                 


Lys Asn Ser Ser Lys Ala Ala Gln Ala Pro Ser Pro Trp Gly Ala Ser 
465                 470                 475                 480 


Gly Asn Ser Val Gly Ser Gln Gly Ser Leu Ser Asn Ala Ser Ala Leu 
                485                 490                 495     


Ser Pro Ser Thr Ile Val Ser Ile Pro Gln Arg Ile His Gln Met Ala 
            500                 505                 510         


Ala Asn His Val Ser Ile Thr Asn Ser Ile Leu His Ser Tyr Asp Tyr 
        515                 520                 525             


Trp Glu Met Ala Asp Asn Leu Ala Lys Glu Asn Arg Glu Phe Phe Asn 
    530                 535                 540                 


Asp Leu Asp Leu Leu Met Gly Pro Val Thr Leu His Ser Ser Met Glu 
545                 550                 555                 560 


His Leu Val Gln Tyr Ser Gln Gln Gly Leu His Trp Leu Arg Asn Ser 
                565                 570                 575     


Ala His Leu Ser 
            580 


<210>  330
<211>  179
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  330

Xaa Ala Ser Lys Pro Ser Leu Val Gln Gln Lys Pro Thr Ala Tyr Val 
1               5                   10                  15      


Arg Pro Met Asp Gly Gln Asp Gln Ala Pro Asp Glu Ser Pro Lys Leu 
            20                  25                  30          


Lys Ser Ser Ser Glu Thr Ser Val His Cys Thr Ser Tyr Arg Gly Val 
        35                  40                  45              


Pro Ala Ser Lys Pro Glu Pro Ala Arg Ala Lys Ala Lys Leu Ser Lys 
    50                  55                  60                  


Phe Ser Ile Pro Lys Gln Gly Glu Glu Ser Arg Ser Gly Glu Thr Asn 
65                  70                  75                  80  


Ser Cys Val Glu Glu Ile Ile Arg Glu Met Thr Trp Leu Pro Pro Leu 
                85                  90                  95      


Ser Ala Ile Gln Ala Pro Gly Lys Val Glu Pro Thr Lys Phe Pro Phe 
            100                 105                 110         


Pro Asn Lys Asp Ser Gln Leu Val Ser Ser Gly His Asn Asn Pro Lys 
        115                 120                 125             


Lys Gly Asp Ala Glu Pro Glu Ser Pro Asp Asn Gly Thr Ser Asn Thr 
    130                 135                 140                 


Ser Met Leu Glu Asp Asp Leu Lys Leu Ser Ser Asp Glu Glu Glu Asn 
145                 150                 155                 160 


Glu Gln Gln Ala Ala Gln Arg Thr Ala Leu Arg Ala Leu Ser Asp Ser 
                165                 170                 175     


Leu Ser Trp 
            


<210>  331
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  331

Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp Asp Leu Glu Ser 
1               5                   10                  15      


Leu Cys Val Tyr Glu Pro Asp Arg Asn Ala Leu Arg Arg Lys Glu Arg 
            20                  25                  30          


Glu Arg Arg Asn Gln Glu Thr Gln Gln Asp Asp Gly Thr Phe Asn Ser 
        35                  40                  45              


Ser Tyr Ser Leu Phe Ser Glu Pro Tyr Lys Thr Asn Lys Gly Asp Glu 
    50                  55                  60                  


Leu Ser Asn Arg Ile Gln Asn Thr Leu Gly Asn Tyr Asp Glu Met Lys 
65                  70                  75                  80  


Asp Phe Leu Thr Asp Arg Ser Asn Gln Ser His Leu Val Gly Val Pro 
                85                  90                  95      


Lys Pro Gly Val Pro Gln Thr Pro Val Asn Lys Ile Asp Glu His Phe 
            100                 105                 110         


Val Ala Asp Ser Arg Ala Gln Asn Gln Pro Ser Ser Ile Cys Ser Thr 
        115                 120                 125             


Thr Thr Ser Thr Pro Ala Ala Val Pro Val Gln Gln Ser Lys Arg Gly 
    130                 135                 140                 


Thr Met Gly Trp Gln Lys Ala Gly His Pro Pro Ser Asp Gly Gln Gln 
145                 150                 155                 160 


Arg 
    


<210>  332
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  332

Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp Asp Leu Glu Ser 
1               5                   10                  15      


Leu Trp Gly Glu Asp Ile Leu Asn Gln Arg Asn Asp Ser Leu Val Val 
            20                  25                  30          


Glu Phe Gln Ser Ser Ala Ser Arg Cys Arg Ser Val Tyr Glu Pro Asp 
        35                  40                  45              


Arg Asn Ala Leu Arg Arg 
    50                  


<210>  333
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  333

Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp Asp Leu Glu Ser 
1               5                   10                  15      


Leu Trp Gly Glu Asp Ile Leu Asn Gln Arg Asn Asp Ser Leu Val Val 
            20                  25                  30          


Glu Phe Gln Ser Ser Ala Ser Arg Cys Arg Ser Val Tyr Glu Pro Asp 
        35                  40                  45              


Arg Asn Ala Leu Arg Arg Lys Glu Arg Glu Arg Arg Asn Gln Glu Thr 
    50                  55                  60                  


Gln Gln Asp Asp Gly Thr Phe Asn Ser Ser Tyr Ser Leu Phe Ser Glu 
65                  70                  75                  80  


Pro Tyr Lys Thr Asn Lys Gly Asp Glu Leu Ser Asn Arg Ile Gln Asn 
                85                  90                  95      


Thr Leu Gly Asn Tyr Asp Glu 
            100             


<210>  334
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  334

Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp Asp Leu Glu Ser 
1               5                   10                  15      


Leu Cys Val Tyr Glu Pro Asp Arg Asn Ala Leu Arg Arg Lys Glu Arg 
            20                  25                  30          


Glu Arg Arg Asn Gln Glu Thr Gln Gln Asp Asp Gly Thr Phe Asn Ser 
        35                  40                  45              


Ser Tyr Ser Leu Phe Ser Glu Pro Tyr Lys Thr Asn Lys Gly Asp Glu 
    50                  55                  60                  


Leu Ser Asn Arg Ile Gln Asn Thr Leu Gly Asn Tyr Asp Glu Met Lys 
65                  70                  75                  80  


Asp Phe Leu Thr Asp Arg Ser Asn Gln Ser His Leu Val Gly Val Pro 
                85                  90                  95      


Lys Pro Gly Val Pro Gln Thr Pro Val Asn Lys Ile Asp Glu His Phe 
            100                 105                 110         


Val Ala 
        


<210>  335
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  335

Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp Asp Leu Glu Ser 
1               5                   10                  15      


Leu Trp Gly Glu Asp Ile Leu Asn Gln Arg Asn Asp Ser Leu Val Val 
            20                  25                  30          


Glu Phe Gln Ser Ser Ala Ser Arg Cys Arg Ser Val Tyr Glu Pro Asp 
        35                  40                  45              


Arg Asn Ala Leu Arg Arg Lys Glu Arg Glu Arg Arg Asn Gln Glu Thr 
    50                  55                  60                  


Gln Gln Asp Asp Gly Thr Phe Asn Ser Ser Tyr Ser Leu Phe Ser Glu 
65                  70                  75                  80  


Pro Tyr Lys Thr Asn Lys Gly Asp Glu Leu Ser Asn Arg Ile Gln Asn 
                85                  90                  95      


Thr Leu Gly Asn Tyr Asp Glu Met Lys Asp Phe Leu Thr Asp Arg Ser 
            100                 105                 110         


Asn Gln Ser His Leu Val Gly Val Pro Lys Pro Gly Val Pro Gln Thr 
        115                 120                 125             


Pro Val Asn Lys Ile Asp Glu His Phe Val Ala Asp Ser Arg Ala Gln 
    130                 135                 140                 


Asn Gln Pro Ser Ser Ile Cys Ser Thr Thr Thr Ser Thr Pro Ala Ala 
145                 150                 155                 160 


Val Pro Val Gln Gln Ser Lys Arg Gly Thr Met Gly Trp Gln Lys Ala 
                165                 170                 175     


Gly His Pro Pro Ser Asp Gly Gln Gln Arg Ala Thr Gln Gln Gly Ser 
            180                 185                 190         


Leu Arg Thr Leu Leu Gly Asp Gly Val Gly Arg Gln Gln Pro Arg Ala 
        195                 200                 205             


Lys Gln Val Cys Asn Val Glu Val Gly Leu Gln Thr Gln Glu Arg Pro 
    210                 215                 220                 


Pro Ala Met Ala Ala Lys His Ser Ser Ser Gly His Cys Val Gln Asn 
225                 230                 235                 240 


Phe Pro Pro Ser Leu Ala Ser Lys Pro Ser Leu Val Gln Gln Lys Pro 
                245                 250                 255     


Thr Ala Tyr Val Arg Pro Met Asp Gly Gln Asp Gln Ala Pro Asp Glu 
            260                 265                 270         


Ser Pro Lys Leu Lys Ser Ser Ser Glu Thr Ser Val His Cys Thr Ser 
        275                 280                 285             


Tyr Arg Gly Val Pro Ala Ser Lys Pro Glu Pro Ala Arg Ala Lys Ala 
    290                 295                 300                 


Lys Leu Ser Lys Phe Ser Ile Pro Lys Gln Gly Glu Glu Ser Arg Ser 
305                 310                 315                 320 


Gly Glu Thr Asn Ser Cys Val Glu Glu Ile Ile Arg Tyr Pro Arg Val 
                325                 330                 335     


Cys Phe Ser Asn Ala Val Gln Thr Glu Pro Ala Leu Pro Gly Pro Gly 
            340                 345                 350         


Cys Thr Gly His Ser Leu Trp Arg Ile Cys Ser Val Gly Pro Pro Gly 
        355                 360                 365             


Ala Gly Arg Arg Gln Pro Thr Cys Leu Cys Ala 
    370                 375                 


<210>  336
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  336

Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp Asp Leu Glu Ser 
1               5                   10                  15      


Leu Trp Gly Glu Asp Ile Leu Asn Gln Arg Asn Asp Ser Leu Val Val 
            20                  25                  30          


Glu Phe Gln Ser Ser Ala Ser Arg Cys Arg Ser Val Tyr Glu Pro Asp 
        35                  40                  45              


Arg Asn Ala Leu Arg Arg Lys Glu Arg Glu Arg Arg Asn Gln Glu Thr 
    50                  55                  60                  


Gln Gln Asp Asp Gly Thr Phe Asn Ser Ser Tyr Ser Leu Phe Ser Glu 
65                  70                  75                  80  


Pro Tyr Lys Thr Asn Lys Gly Asp Glu Leu Ser Asn Arg Ile Gln Asn 
                85                  90                  95      


Thr Leu Gly Asn Tyr Asp Glu Met Lys Asp Phe Leu Thr Asp Arg Ser 
            100                 105                 110         


Asn Gln Ser 
        115 


<210>  337
<211>  608
<212>  PRT
<213>  Homo sapiens

<400>  337

Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp Asp Leu Glu Ser 
1               5                   10                  15      


Leu Cys Val Tyr Glu Pro Asp Arg Asn Ala Leu Arg Arg Lys Glu Arg 
            20                  25                  30          


Glu Arg Arg Asn Gln Glu Thr Gln Gln Asp Asp Gly Thr Phe Asn Ser 
        35                  40                  45              


Ser Tyr Ser Leu Phe Ser Glu Pro Tyr Lys Thr Asn Lys Gly Asp Glu 
    50                  55                  60                  


Leu Ser Asn Arg Ile Gln Asn Thr Leu Gly Asn Tyr Asp Glu Met Lys 
65                  70                  75                  80  


Asp Phe Leu Thr Asp Arg Ser Asn Gln Ser His Leu Val Gly Val Pro 
                85                  90                  95      


Lys Pro Gly Val Pro Gln Thr Pro Val Asn Lys Ile Asp Glu His Phe 
            100                 105                 110         


Val Ala Asp Ser Arg Ala Gln Asn Gln Pro Ser Ser Ile Cys Ser Thr 
        115                 120                 125             


Thr Thr Ser Thr Pro Ala Ala Val Pro Val Gln Gln Ser Lys Arg Gly 
    130                 135                 140                 


Thr Met Gly Trp Gln Lys Ala Gly His Pro Pro Ser Asp Gly Gln Gln 
145                 150                 155                 160 


Arg Ala Thr Gln Gln Gly Ser Leu Arg Thr Leu Leu Gly Asp Gly Val 
                165                 170                 175     


Gly Arg Gln Gln Pro Arg Ala Lys Gln Val Cys Asn Val Glu Val Gly 
            180                 185                 190         


Leu Gln Thr Gln Glu Arg Pro Pro Ala Met Ala Ala Lys His Ser Ser 
        195                 200                 205             


Ser Gly His Cys Val Gln Asn Phe Pro Pro Ser Leu Ala Ser Lys Pro 
    210                 215                 220                 


Ser Leu Val Gln Gln Lys Pro Thr Ala Tyr Val Arg Pro Met Asp Gly 
225                 230                 235                 240 


Gln Asp Gln Ala Pro Asp Glu Ser Pro Lys Leu Lys Ser Ser Ser Glu 
                245                 250                 255     


Thr Ser Val His Cys Thr Ser Tyr Arg Gly Val Pro Ala Ser Lys Pro 
            260                 265                 270         


Glu Pro Ala Arg Ala Lys Ala Lys Leu Ser Lys Phe Ser Ile Pro Lys 
        275                 280                 285             


Gln Gly Glu Glu Ser Arg Ser Gly Glu Thr Asn Ser Cys Val Glu Glu 
    290                 295                 300                 


Ile Ile Arg Glu Met Thr Trp Leu Pro Pro Leu Ser Ala Ile Gln Ala 
305                 310                 315                 320 


Pro Gly Lys Val Glu Pro Thr Lys Phe Pro Phe Pro Asn Lys Asp Ser 
                325                 330                 335     


Gln Leu Val Ser Ser Gly His Asn Asn Pro Lys Lys Gly Asp Ala Glu 
            340                 345                 350         


Pro Glu Ser Pro Asp Asn Gly Thr Ser Asn Thr Ser Met Leu Glu Asp 
        355                 360                 365             


Asp Leu Lys Leu Ser Ser Asp Glu Glu Glu Asn Glu Gln Gln Ala Ala 
    370                 375                 380                 


Gln Arg Thr Ala Leu Arg Ala Leu Ser Asp Ser Ala Val Val Gln Gln 
385                 390                 395                 400 


Pro Asn Cys Arg Thr Ser Val Pro Ser Ser Lys Gly Ser Ser Ser Ser 
                405                 410                 415     


Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Asp Ser Glu Ser Ser Ser 
            420                 425                 430         


Gly Ser Asp Ser Glu Thr Glu Ser Ser Ser Ser Glu Ser Glu Gly Ser 
        435                 440                 445             


Lys Pro Pro His Phe Ser Ser Pro Glu Ala Glu Pro Ala Ser Ser Asn 
    450                 455                 460                 


Lys Trp Gln Leu Asp Lys Trp Leu Asn Lys Val Asn Pro His Lys Pro 
465                 470                 475                 480 


Pro Ile Leu Ile Gln Asn Glu Ser His Gly Ser Glu Ser Asn Gln Tyr 
                485                 490                 495     


Tyr Asn Pro Val Lys Glu Asp Val Gln Asp Cys Gly Lys Val Pro Asp 
            500                 505                 510         


Val Cys Gln Pro Ser Leu Arg Glu Lys Glu Ile Lys Ser Thr Cys Lys 
        515                 520                 525             


Glu Glu Gln Arg Pro Arg Thr Ala Asn Lys Ala Pro Gly Ser Lys Gly 
    530                 535                 540                 


Val Lys Gln Lys Ser Pro Pro Ala Ala Val Ala Val Ala Val Ser Ala 
545                 550                 555                 560 


Ala Ala Pro Pro Pro Ala Val Pro Cys Ala Pro Ala Glu Asn Ala Pro 
                565                 570                 575     


Ala Pro Ala Arg Arg Ser Ala Gly Lys Lys Pro Thr Arg Arg Thr Glu 
            580                 585                 590         


Arg Thr Ser Ala Gly Asp Gly Ala Asn Cys His Arg Pro Glu Glu Pro 
        595                 600                 605             


<210>  338
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  338

Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp Asp Leu Glu Ser 
1               5                   10                  15      


Leu Cys Val Tyr Glu Pro Asp Arg Asn Ala Leu Arg Arg Lys Glu Arg 
            20                  25                  30          


Glu Arg Arg Asn Gln Glu Thr Gln Gln Asp Asp 
        35                  40              


<210>  339
<211>  134
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  339

Xaa Ser Ala Pro Pro Ser His Thr Ser Asp Thr Pro Ala Glu Lys Ala 
1               5                   10                  15      


Leu Pro Lys Ser Lys Arg Lys Arg Lys Cys Asp Asn Glu Asp Asp Tyr 
            20                  25                  30          


Arg Glu Ile Lys Lys Ser Gln Gly Glu Lys Asp Ser Ser Ser Arg Leu 
        35                  40                  45              


Ala Thr Ser Thr Ser Asn Thr Leu Ser Ala Asn His Cys Asn Met Asn 
    50                  55                  60                  


Ile Asn Ser Val Ala Ile Pro Ile Asn Lys Asn Glu Lys Met Leu Arg 
65                  70                  75                  80  


Ser Pro Ile Ser Pro Leu Ser Asp Ala Ser Lys His Lys Tyr Thr Ser 
                85                  90                  95      


Glu Asp Leu Thr Ser Ser Ser Arg Pro Asn Gly Asn Ser Leu Phe Thr 
            100                 105                 110         


Ser Ala Ser Ser Ser Lys Lys Pro Lys Ala Asp Ser Gln Leu Gln Pro 
        115                 120                 125             


His Gly Gly Asp Leu Thr 
    130                 


<210>  340
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  340

Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp Asp Leu Glu Ser 
1               5                   10                  15      


Leu Trp Gly Glu Asp Ile Leu Asn Gln Arg Asn Asp Ser Leu Val Val 
            20                  25                  30          


Glu Phe Gln Ser Ser Ala Ser Arg Cys Arg Ser Val Tyr Glu Pro Asp 
        35                  40                  45              


Arg Asn Ala Leu Arg Arg Lys Glu Arg Glu Arg Arg Asn Gln Glu Thr 
    50                  55                  60                  


Gln Gln Asp Asp Gly Thr Phe Asn Ser Ser Tyr Ser Leu Phe Ser Glu 
65                  70                  75                  80  


Pro Tyr Lys Thr Asn Lys Gly Asp Glu Leu Ser Asn Arg Ile Gln Asn 
                85                  90                  95      


Thr Leu Gly Asn Tyr Asp Glu Met Lys Asp Phe Leu Thr Asp Arg Ser 
            100                 105                 110         


Asn Gln Ser His Leu Val Gly Val Pro Lys Pro Gly Val Pro Gln Thr 
        115                 120                 125             


Pro Val Asn Lys Ile Asp Glu His Phe Val Ala Asp Ser Arg Ala 
    130                 135                 140             


<210>  341
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  341

Met Ala Ala Leu Gly Gly Asp Gly Leu Arg Leu Leu Ser Val Ser Arg 
1               5                   10                  15      


Pro Glu Arg Pro Pro Glu Ser Ala Ala Leu Gly Gly Leu Gly Pro Gly 
            20                  25                  30          


Leu Cys Cys Trp Val Ser Val Phe Ser Cys Leu Ser Leu Ala Cys Ser 
        35                  40                  45              


Tyr Val Gly Ser Leu Tyr Val Trp Lys Ser Glu Leu Pro Arg Asp His 
    50                  55                  60                  


Pro Ala Val Ile Lys Arg Arg Phe Thr Ser Val Leu Val Val Ser Ser 
65                  70                  75                  80  


Leu Ser Pro Leu Cys Val Leu Leu Trp Arg Glu Leu Thr Gly Ile Gln 
                85                  90                  95      


Pro Gly Thr Ser Leu Leu Thr Leu Met Gly Phe Arg Leu Glu Gly Ile 
            100                 105                 110         


Phe Pro Ala Ala Leu Leu Pro Leu Leu Leu Thr Met Ile Leu Phe Leu 
        115                 120                 125             


Gly Pro Leu Met Gln Leu Ser Met Asp Cys Pro Cys Asp Leu Ala Asp 
    130                 135                 140                 


Gly Leu Lys Val Val Leu Ala Pro Arg Ser Trp Ala Arg Cys Leu Thr 
145                 150                 155                 160 


Asp Met Arg Trp Leu Arg Asn Gln Val Ile Ala Pro Leu Thr Glu Glu 
                165                 170                 175     


Leu Val Phe Arg Ala Cys Met Leu Pro Met Leu Ala Pro Cys Met Gly 
            180                 185                 190         


Leu Gly Pro Ala Val Phe Thr Cys Pro Leu Phe Phe Gly Val Ala His 
        195                 200                 205             


Phe His His Ile Ile Glu Gln Leu Arg Phe Arg Gln Ser Ser Val Gly 
    210                 215                 220                 


Asn Ile Phe Leu Ser Ala Ala Phe Gln Phe Ser Tyr Thr Ala Val Phe 
225                 230                 235                 240 


Gly Ala Tyr Thr Ala Phe Leu Phe Ile Arg Thr Gly His Leu Ile Gly 
                245                 250                 255     


Pro Val Leu Cys His Ser Phe Cys Asn Tyr Met Gly Phe Pro Ala Val 
            260                 265                 270         


Cys Ala Ala Leu Glu His Pro Gln Arg Arg Pro Leu Leu Ala Gly Tyr 
        275                 280                 285             


Ala Leu Gly Val Gly Leu Phe Leu Leu Leu Leu Gln Pro Leu Thr Asp 
    290                 295                 300                 


Pro Lys Leu Tyr Gly Ser Leu Pro Leu Cys Val Leu Leu Glu Arg Ala 
305                 310                 315                 320 


Gly Asp Ser Glu Ala Pro Leu Cys Ser 
                325                 


<210>  342
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  342

Met Ala Ala Leu Gly Gly Asp Gly Leu Arg Leu Leu Ser Val Ser Arg 
1               5                   10                  15      


Pro Glu Arg Pro Pro Glu Ser Ala Ala Leu Gly Gly Leu Gly Pro Gly 
            20                  25                  30          


Leu Cys Cys Trp Val Ser Val Phe Ser Cys Leu Ser Leu Ala Cys Ser 
        35                  40                  45              


Tyr Val Gly Ser Leu Tyr Val Trp Lys Ser Glu Leu Pro Arg Asp His 
    50                  55                  60                  


Pro Ala Val Ile Lys Arg Arg Phe Thr Ser Val Leu Val Val Ser Ser 
65                  70                  75                  80  


Leu Ser Pro Leu Cys Val Leu Leu Trp Arg Glu Leu Thr Gly Ile Gln 
                85                  90                  95      


Ala His Pro Cys Ser Pro 
            100         


<210>  343
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  343

Met Ala Ala Leu Gly Gly Asp Gly Leu Arg Leu Leu Ser Val Ser Arg 
1               5                   10                  15      


Pro Glu Arg Pro Pro Glu Ser Ala Ala Leu Gly Gly Leu Gly Pro Gly 
            20                  25                  30          


Leu Cys Cys Trp Val Ser Val Phe Ser Cys Leu Ser Leu Ala Cys Ser 
        35                  40                  45              


Tyr Val Gly Ser Leu Tyr Val Trp Lys Ser Glu Leu Pro Arg Asp His 
    50                  55                  60                  


Pro Ala Val Ile Lys Arg Arg Phe Thr Ser Val Leu Val Val Ser Ser 
65                  70                  75                  80  


Leu Ser Pro Leu Cys Val Leu Leu Trp Arg Glu Leu Thr Gly Ile Gln 
                85                  90                  95      


Pro Gly Thr Ser Leu Leu Thr Leu Met Gly Phe Arg Leu Glu Gly Ile 
            100                 105                 110         


Phe Pro Ala Ala Leu Leu Pro Leu Leu Leu Thr Met Ile Leu Phe Leu 
        115                 120                 125             


Gly Pro Leu Met Gln Leu Ser Met Asp Cys Pro Cys Asp Leu Ala Asp 
    130                 135                 140                 


Gly Leu Lys Val Val Leu Ala Pro Arg Ser Trp Ala Arg Cys Leu Thr 
145                 150                 155                 160 


Asp Met Arg Trp Leu Arg Asn Gln Val Ile Ala Pro Leu Thr Glu Glu 
                165                 170                 175     


Leu Val Phe Arg Ala Cys Met Leu Pro Met Leu Ala Pro Cys Met Gly 
            180                 185                 190         


Leu Gly Pro Ala Val Phe Thr Cys Pro Leu Phe Phe Gly Val Ala His 
        195                 200                 205             


Phe His His Ile Ile Glu Gln Leu Arg Phe Arg Gln Ser Ser Val Gly 
    210                 215                 220                 


Asn Ile Phe Leu Ser Ala Gly His Leu Ile Gly Pro Val Leu Cys His 
225                 230                 235                 240 


Ser Phe Cys Asn Tyr Met Gly Phe Pro Ala Val Cys Ala Ala Leu Glu 
                245                 250                 255     


His Pro Gln Arg Arg Pro Leu Leu Ala Gly Tyr Ala Leu Gly Val Gly 
            260                 265                 270         


Leu Phe Leu Leu Leu Leu Gln Pro Leu Thr Asp Pro Lys Leu Tyr Gly 
        275                 280                 285             


Ser Leu Pro Leu Cys Val Leu Leu Glu Arg Ala Gly Asp Ser Glu Ala 
    290                 295                 300                 


Pro Leu Cys Ser 
305             


<210>  344
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  344

Met Ile Leu Phe Leu Gly Pro Leu Met Gln Leu Ser Met Asp Cys Pro 
1               5                   10                  15      


Cys Asp Leu Ala Asp Gly Leu Lys Val Val Leu Ala Pro Arg Ser Trp 
            20                  25                  30          


Ala Arg Cys Leu Thr Asp Met Arg Trp Leu Arg Asn Gln Val Ile Ala 
        35                  40                  45              


Pro Leu Thr Glu Glu Leu Val Phe Arg Ala Cys Met Leu Pro Met Leu 
    50                  55                  60                  


Ala Pro Cys Met Gly Leu Gly Pro Ala Val Phe Thr Cys Pro Leu Phe 
65                  70                  75                  80  


Phe Gly Val Ala His Phe His His Ile Ile Glu Gln Leu Arg Phe Arg 
                85                  90                  95      


Gln Ser Ser Val Gly Asn Ile Phe Leu Ser Ala Ala Phe Gln Phe Ser 
            100                 105                 110         


Tyr Thr Ala Val Phe Gly Ala Tyr Thr Ala Phe Leu Phe Ile Arg Thr 
        115                 120                 125             


Gly His Leu Ile Gly Pro Val Leu Cys His Ser Phe Cys Asn Tyr Met 
    130                 135                 140                 


Gly Phe Pro Ala Val Cys Ala Ala Leu Glu His Pro Gln Arg Arg Pro 
145                 150                 155                 160 


Leu Leu Ala Gly Tyr Ala Leu Gly Val Gly Leu Phe Leu Leu Leu Leu 
                165                 170                 175     


Gln Pro Leu Thr Asp Pro Lys Leu Tyr Gly Ser Leu Pro Leu Cys Val 
            180                 185                 190         


Leu Leu Glu Arg Ala Gly Asp Ser Glu Ala Pro Leu Cys Ser 
        195                 200                 205     


<210>  345
<211>  1154
<212>  PRT
<213>  Homo sapiens

<400>  345

Met Gln Tyr Leu Asn Ile Lys Glu Asp Cys Asn Ala Met Ala Phe Cys 
1               5                   10                  15      


Ala Lys Met Arg Ser Ser Lys Lys Thr Glu Val Asn Leu Glu Ala Pro 
            20                  25                  30          


Glu Pro Gly Val Glu Val Ile Phe Tyr Leu Ser Asp Arg Glu Pro Leu 
        35                  40                  45              


Arg Leu Gly Ser Gly Glu Tyr Thr Ala Glu Glu Leu Cys Ile Arg Ala 
    50                  55                  60                  


Ala Gln Ala Cys Arg Ile Ser Pro Leu Cys His Asn Leu Phe Ala Leu 
65                  70                  75                  80  


Tyr Asp Glu Asn Thr Lys Leu Trp Tyr Ala Pro Asn Arg Thr Ile Thr 
                85                  90                  95      


Val Asp Asp Lys Met Ser Leu Arg Leu His Tyr Arg Met Arg Phe Tyr 
            100                 105                 110         


Phe Thr Asn Trp His Gly Thr Asn Asp Asn Glu Gln Ser Val Trp Arg 
        115                 120                 125             


His Ser Pro Lys Lys Gln Lys Asn Gly Tyr Glu Lys Lys Lys Ile Pro 
    130                 135                 140                 


Asp Ala Thr Pro Leu Leu Asp Ala Ser Ser Leu Glu Tyr Leu Phe Ala 
145                 150                 155                 160 


Gln Gly Gln Tyr Asp Leu Val Lys Cys Leu Ala Pro Ile Arg Asp Pro 
                165                 170                 175     


Lys Thr Glu Gln Asp Gly His Asp Ile Glu Asn Glu Cys Leu Gly Met 
            180                 185                 190         


Ala Val Leu Ala Ile Ser His Tyr Ala Met Met Lys Lys Met Gln Leu 
        195                 200                 205             


Pro Glu Leu Pro Lys Asp Ile Ser Tyr Lys Arg Tyr Ile Pro Glu Thr 
    210                 215                 220                 


Leu Asn Lys Ser Ile Arg Gln Arg Asn Leu Leu Thr Arg Met Arg Ile 
225                 230                 235                 240 


Asn Asn Val Phe Lys Asp Phe Leu Lys Glu Phe Asn Asn Lys Thr Ile 
                245                 250                 255     


Cys Asp Ser Ser Val Ser Thr His Asp Leu Lys Val Lys Tyr Leu Ala 
            260                 265                 270         


Thr Leu Glu Thr Leu Thr Lys His Tyr Gly Ala Glu Ile Phe Glu Thr 
        275                 280                 285             


Ser Met Leu Leu Ile Ser Ser Glu Asn Glu Met Asn Trp Phe His Ser 
    290                 295                 300                 


Asn Asp Gly Gly Asn Val Leu Tyr Tyr Glu Val Met Val Thr Gly Asn 
305                 310                 315                 320 


Leu Gly Ile Gln Trp Arg His Lys Pro Asn Val Val Ser Val Glu Lys 
                325                 330                 335     


Glu Lys Asn Lys Leu Lys Arg Lys Lys Leu Glu Asn Lys His Lys Lys 
            340                 345                 350         


Asp Glu Glu Lys Asn Lys Ile Arg Glu Glu Trp Asn Asn Phe Ser Tyr 
        355                 360                 365             


Phe Pro Glu Ile Thr His Ile Val Ile Lys Glu Ser Val Val Ser Ile 
    370                 375                 380                 


Asn Lys Gln Asp Asn Lys Lys Met Glu Leu Lys Leu Ser Ser His Glu 
385                 390                 395                 400 


Glu Ala Leu Ser Phe Val Ser Leu Val Asp Gly Tyr Phe Arg Leu Thr 
                405                 410                 415     


Ala Asp Ala His His Tyr Leu Cys Thr Asp Val Ala Pro Pro Leu Ile 
            420                 425                 430         


Val His Asn Ile Gln Asn Gly Cys His Gly Pro Ile Cys Thr Glu Tyr 
        435                 440                 445             


Ala Ile Asn Lys Leu Arg Gln Glu Gly Ser Glu Glu Gly Met Tyr Val 
    450                 455                 460                 


Leu Arg Trp Ser Cys Thr Asp Phe Asp Asn Ile Leu Met Thr Val Thr 
465                 470                 475                 480 


Cys Phe Glu Lys Ser Glu Gln Val Gln Gly Ala Gln Lys Gln Phe Lys 
                485                 490                 495     


Asn Phe Gln Ile Glu Val Gln Lys Gly Arg Tyr Ser Leu His Gly Ser 
            500                 505                 510         


Asp Arg Ser Phe Pro Ser Leu Gly Asp Leu Met Ser His Leu Lys Lys 
        515                 520                 525             


Gln Ile Leu Arg Thr Asp Asn Ile Ser Phe Met Leu Lys Arg Cys Cys 
    530                 535                 540                 


Gln Pro Lys Pro Arg Glu Ile Ser Asn Leu Leu Val Ala Thr Lys Lys 
545                 550                 555                 560 


Ala Gln Glu Trp Gln Pro Val Tyr Pro Met Ser Gln Leu Ser Phe Asp 
                565                 570                 575     


Arg Ile Leu Lys Lys Asp Leu Val Gln Gly Glu His Leu Gly Arg Gly 
            580                 585                 590         


Thr Arg Thr His Ile Tyr Ser Gly Thr Leu Met Asp Tyr Lys Asp Asp 
        595                 600                 605             


Glu Gly Thr Ser Glu Glu Lys Lys Ile Lys Val Ile Leu Lys Val Leu 
    610                 615                 620                 


Asp Pro Ser His Arg Asp Ile Ser Leu Ala Phe Phe Glu Ala Ala Ser 
625                 630                 635                 640 


Met Met Arg Gln Val Ser His Lys His Ile Val Tyr Leu Tyr Gly Val 
                645                 650                 655     


Cys Val Arg Asp Val Glu Asn Ile Met Val Glu Glu Phe Val Glu Gly 
            660                 665                 670         


Gly Pro Leu Asp Leu Phe Met His Arg Lys Ser Asp Val Leu Thr Thr 
        675                 680                 685             


Pro Trp Lys Phe Lys Val Ala Lys Gln Leu Ala Ser Ala Leu Ser Tyr 
    690                 695                 700                 


Leu Glu Asp Lys Asp Leu Val His Gly Asn Val Cys Thr Lys Asn Leu 
705                 710                 715                 720 


Leu Leu Ala Arg Glu Gly Ile Asp Ser Glu Cys Gly Pro Phe Ile Lys 
                725                 730                 735     


Leu Ser Asp Pro Gly Ile Pro Ile Thr Val Leu Ser Arg Gln Glu Cys 
            740                 745                 750         


Ile Glu Arg Ile Pro Trp Ile Ala Pro Glu Cys Val Glu Asp Ser Lys 
        755                 760                 765             


Asn Leu Ser Val Ala Ala Asp Lys Trp Ser Phe Gly Thr Thr Leu Trp 
    770                 775                 780                 


Glu Ile Cys Tyr Asn Gly Glu Ile Pro Leu Lys Asp Lys Thr Leu Ile 
785                 790                 795                 800 


Glu Lys Glu Arg Phe Tyr Glu Ser Arg Cys Arg Pro Val Thr Pro Ser 
                805                 810                 815     


Cys Lys Glu Leu Ala Asp Leu Met Thr Arg Cys Met Asn Tyr Asp Pro 
            820                 825                 830         


Asn Gln Arg Pro Phe Phe Arg Ala Ile Met Arg Asp Ile Asn Lys Leu 
        835                 840                 845             


Glu Glu Gln Asn Pro Asp Ile Val Ser Glu Lys Lys Pro Ala Thr Glu 
    850                 855                 860                 


Val Asp Pro Thr His Phe Glu Lys Arg Phe Leu Lys Arg Ile Arg Asp 
865                 870                 875                 880 


Leu Gly Glu Gly His Phe Gly Lys Val Glu Leu Cys Arg Tyr Asp Pro 
                885                 890                 895     


Glu Gly Asp Asn Thr Gly Glu Gln Val Ala Val Lys Ser Leu Lys Pro 
            900                 905                 910         


Glu Ser Gly Gly Asn His Ile Ala Asp Leu Lys Lys Glu Ile Glu Ile 
        915                 920                 925             


Leu Arg Asn Leu Tyr His Glu Asn Ile Val Lys Tyr Lys Gly Ile Cys 
    930                 935                 940                 


Thr Glu Asp Gly Gly Asn Gly Ile Lys Leu Ile Met Glu Phe Leu Pro 
945                 950                 955                 960 


Ser Gly Ser Leu Lys Glu Tyr Leu Pro Lys Asn Lys Asn Lys Ile Asn 
                965                 970                 975     


Leu Lys Gln Gln Leu Lys Tyr Ala Val Gln Ile Cys Lys Gly Met Asp 
            980                 985                 990         


Tyr Leu Gly Ser Arg Gln Tyr Val  His Arg Asp Leu Ala  Ala Arg Asn 
        995                 1000                 1005             


Val Leu  Val Glu Ser Glu His  Gln Val Lys Ile Gly  Asp Phe Gly 
    1010                 1015                 1020             


Leu Thr  Lys Ala Ile Glu Thr  Asp Lys Glu Tyr Tyr  Thr Val Lys 
    1025                 1030                 1035             


Asp Asp  Arg Asp Ser Pro Val  Phe Trp Tyr Ala Pro  Glu Cys Leu 
    1040                 1045                 1050             


Met Gln  Ser Lys Phe Tyr Ile  Ala Ser Asp Val Trp  Ser Phe Gly 
    1055                 1060                 1065             


Val Thr  Leu His Glu Leu Leu  Thr Tyr Cys Asp Ser  Asp Ser Ser 
    1070                 1075                 1080             


Pro Met  Ala Leu Phe Leu Lys  Met Ile Gly Pro Thr  His Gly Gln 
    1085                 1090                 1095             


Met Thr  Val Thr Arg Leu Val  Asn Thr Leu Lys Glu  Gly Lys Arg 
    1100                 1105                 1110             


Leu Pro  Cys Pro Pro Asn Cys  Pro Asp Glu Val Tyr  Gln Leu Met 
    1115                 1120                 1125             


Arg Lys  Cys Trp Glu Phe Gln  Pro Ser Asn Arg Thr  Ser Phe Gln 
    1130                 1135                 1140             


Asn Leu  Ile Glu Gly Phe Glu  Ala Leu Leu Lys 
    1145                 1150                 


<210>  346
<211>  708
<212>  PRT
<213>  Homo sapiens

<400>  346

Met Gln Tyr Leu Asn Ile Lys Glu Asp Cys Asn Ala Met Ala Phe Cys 
1               5                   10                  15      


Ala Lys Met Arg Ser Ser Lys Lys Thr Glu Val Asn Leu Glu Ala Pro 
            20                  25                  30          


Glu Pro Gly Val Glu Val Ile Phe Tyr Leu Ser Asp Arg Glu Pro Leu 
        35                  40                  45              


Arg Leu Gly Ser Gly Glu Tyr Thr Ala Glu Glu Leu Cys Ile Arg Ala 
    50                  55                  60                  


Ala Gln Ala Cys Arg Ile Ser Pro Leu Cys His Asn Leu Phe Ala Leu 
65                  70                  75                  80  


Tyr Asp Glu Asn Thr Lys Leu Trp Tyr Ala Pro Asn Arg Thr Ile Thr 
                85                  90                  95      


Val Asp Asp Lys Met Ser Leu Arg Leu His Tyr Arg Met Arg Phe Tyr 
            100                 105                 110         


Phe Thr Asn Trp His Gly Thr Asn Asp Asn Glu Gln Ser Val Trp Arg 
        115                 120                 125             


His Ser Pro Lys Lys Gln Lys Asn Gly Tyr Glu Lys Lys Lys Ile Pro 
    130                 135                 140                 


Asp Ala Thr Pro Leu Leu Asp Ala Ser Ser Leu Glu Tyr Leu Phe Ala 
145                 150                 155                 160 


Gln Gly Gln Tyr Asp Leu Val Lys Cys Leu Ala Pro Ile Arg Asp Pro 
                165                 170                 175     


Lys Thr Glu Gln Asp Gly His Asp Ile Glu Asn Glu Cys Leu Gly Met 
            180                 185                 190         


Ala Val Leu Ala Ile Ser His Tyr Ala Met Met Lys Lys Met Gln Leu 
        195                 200                 205             


Pro Glu Leu Pro Lys Asp Ile Ser Tyr Lys Arg Tyr Ile Pro Glu Thr 
    210                 215                 220                 


Leu Asn Lys Ser Ile Arg Gln Arg Asn Leu Leu Thr Arg Met Arg Ile 
225                 230                 235                 240 


Asn Asn Val Phe Lys Asp Phe Leu Lys Glu Phe Asn Asn Lys Thr Ile 
                245                 250                 255     


Cys Asp Ser Ser Val Ser Thr His Asp Leu Lys Val Lys Tyr Leu Ala 
            260                 265                 270         


Thr Leu Glu Thr Leu Thr Lys His Tyr Gly Ala Glu Ile Phe Glu Thr 
        275                 280                 285             


Ser Met Leu Leu Ile Ser Ser Glu Asn Glu Met Asn Trp Phe His Ser 
    290                 295                 300                 


Asn Asp Gly Gly Asn Val Leu Tyr Tyr Glu Val Met Val Thr Gly Asn 
305                 310                 315                 320 


Leu Gly Ile Gln Trp Arg His Lys Pro Asn Val Val Ser Val Glu Lys 
                325                 330                 335     


Glu Lys Asn Lys Leu Lys Arg Lys Lys Leu Glu Asn Lys His Lys Lys 
            340                 345                 350         


Asp Glu Glu Lys Asn Lys Ile Arg Glu Glu Trp Asn Asn Phe Ser Tyr 
        355                 360                 365             


Phe Pro Glu Ile Thr His Ile Val Ile Lys Glu Ser Val Val Ser Ile 
    370                 375                 380                 


Asn Lys Gln Asp Asn Lys Lys Met Glu Leu Lys Leu Ser Ser His Glu 
385                 390                 395                 400 


Glu Ala Leu Ser Phe Val Ser Leu Val Asp Gly Tyr Phe Arg Leu Thr 
                405                 410                 415     


Ala Asp Ala His His Tyr Leu Cys Thr Asp Val Ala Pro Pro Leu Ile 
            420                 425                 430         


Val His Asn Ile Gln Asn Gly Cys His Gly Pro Ile Cys Thr Glu Tyr 
        435                 440                 445             


Ala Ile Asn Lys Leu Arg Gln Glu Gly Ser Glu Glu Gly Met Tyr Val 
    450                 455                 460                 


Leu Arg Trp Ser Cys Thr Asp Phe Asp Asn Ile Leu Met Thr Val Thr 
465                 470                 475                 480 


Cys Phe Glu Lys Ser Glu Gln Val Gln Gly Ala Gln Lys Gln Phe Lys 
                485                 490                 495     


Asn Phe Gln Ile Glu Val Gln Lys Gly Arg Tyr Ser Leu His Gly Ser 
            500                 505                 510         


Asp Arg Ser Phe Pro Ser Leu Gly Asp Leu Met Ser His Leu Lys Lys 
        515                 520                 525             


Gln Ile Leu Arg Thr Asp Asn Ile Ser Phe Met Leu Lys Arg Cys Cys 
    530                 535                 540                 


Gln Pro Lys Pro Arg Glu Ile Ser Asn Leu Leu Val Ala Thr Lys Lys 
545                 550                 555                 560 


Ala Gln Glu Trp Gln Pro Val Tyr Pro Met Ser Gln Leu Ser Phe Asp 
                565                 570                 575     


Arg Ile Leu Lys Lys Asp Leu Val Gln Gly Glu His Leu Gly Arg Gly 
            580                 585                 590         


Thr Arg Thr His Ile Tyr Ser Gly Thr Leu Met Asp Tyr Lys Asp Asp 
        595                 600                 605             


Glu Gly Thr Ser Glu Glu Lys Lys Ile Lys Val Ile Leu Lys Val Leu 
    610                 615                 620                 


Asp Pro Ser His Arg Asp Ile Ser Leu Ala Phe Phe Glu Ala Ala Ser 
625                 630                 635                 640 


Met Met Arg Gln Val Ser His Lys His Ile Val Tyr Leu Tyr Gly Val 
                645                 650                 655     


Cys Val Arg Asp Val Glu Ser Lys Cys Val Leu Phe Gln Arg Gly Gly 
            660                 665                 670         


Trp Pro Gly Trp Gly Ala Trp Val Leu Trp Arg Trp Trp Arg Leu Phe 
        675                 680                 685             


Pro Pro Ser Arg Cys Pro Gly Phe Leu Pro Phe Phe Leu Gln Leu Arg 
    690                 695                 700                 


Arg Leu Arg Asp 
705             


<210>  347
<211>  1152
<212>  PRT
<213>  Homo sapiens

<400>  347

Met Gln Tyr Leu Asn Ile Lys Glu Asp Cys Asn Ala Met Ala Phe Cys 
1               5                   10                  15      


Ala Lys Met Arg Ser Ser Lys Lys Thr Glu Val Asn Leu Glu Ala Pro 
            20                  25                  30          


Glu Pro Gly Val Glu Val Ile Phe Tyr Leu Ser Asp Arg Glu Pro Leu 
        35                  40                  45              


Arg Leu Gly Ser Gly Glu Tyr Thr Ala Glu Glu Leu Cys Ile Arg Ala 
    50                  55                  60                  


Ala Gln Ala Cys Arg Ile Ser Pro Leu Cys His Asn Leu Phe Ala Leu 
65                  70                  75                  80  


Tyr Asp Glu Asn Thr Lys Leu Trp Tyr Ala Pro Asn Arg Thr Ile Thr 
                85                  90                  95      


Val Asp Asp Lys Met Ser Leu Arg Leu His Tyr Arg Met Arg Phe Tyr 
            100                 105                 110         


Phe Thr Asn Trp His Gly Thr Asn Asp Asn Glu Gln Ser Val Trp Arg 
        115                 120                 125             


His Ser Pro Lys Lys Gln Lys Asn Gly Tyr Glu Lys Lys Lys Ile Pro 
    130                 135                 140                 


Asp Ala Thr Pro Leu Leu Asp Ala Ser Ser Leu Glu Tyr Leu Phe Ala 
145                 150                 155                 160 


Gln Gly Gln Tyr Asp Leu Val Lys Cys Leu Ala Pro Ile Arg Asp Pro 
                165                 170                 175     


Lys Thr Glu Gln Asp Gly His Asp Ile Glu Asn Glu Cys Leu Gly Met 
            180                 185                 190         


Ala Val Leu Ala Ile Ser His Tyr Ala Met Met Lys Lys Met Gln Leu 
        195                 200                 205             


Pro Glu Leu Pro Lys Asp Ile Ser Tyr Lys Arg Tyr Ile Pro Glu Thr 
    210                 215                 220                 


Leu Asn Lys Ser Ile Arg Gln Arg Asn Leu Leu Thr Arg Met Arg Ile 
225                 230                 235                 240 


Asn Asn Val Phe Lys Asp Phe Leu Lys Glu Phe Asn Asn Lys Thr Ile 
                245                 250                 255     


Cys Asp Ser Ser Val Ser Thr His Asp Leu Lys Val Lys Tyr Leu Ala 
            260                 265                 270         


Thr Leu Glu Thr Leu Thr Lys His Tyr Gly Ala Glu Ile Phe Glu Thr 
        275                 280                 285             


Ser Met Leu Leu Ile Ser Ser Glu Asn Glu Met Asn Trp Phe His Ser 
    290                 295                 300                 


Asn Asp Gly Gly Asn Val Leu Tyr Tyr Glu Val Met Val Thr Gly Asn 
305                 310                 315                 320 


Leu Gly Ile Gln Trp Arg His Lys Pro Asn Val Val Ser Val Glu Lys 
                325                 330                 335     


Glu Lys Asn Lys Leu Lys Arg Lys Lys Leu Glu Asn Lys His Lys Lys 
            340                 345                 350         


Asp Glu Glu Lys Asn Lys Ile Arg Glu Glu Trp Asn Asn Phe Ser Tyr 
        355                 360                 365             


Phe Pro Glu Ile Thr His Ile Val Ile Lys Glu Ser Val Val Ser Ile 
    370                 375                 380                 


Asn Lys Gln Asp Asn Lys Lys Met Glu Leu Lys Leu Ser Ser His Glu 
385                 390                 395                 400 


Glu Ala Leu Ser Phe Val Ser Leu Val Asp Gly Tyr Phe Arg Leu Thr 
                405                 410                 415     


Ala Asp Ala His His Tyr Leu Cys Thr Asp Val Ala Pro Pro Leu Ile 
            420                 425                 430         


Val His Asn Ile Gln Asn Gly Cys His Gly Pro Ile Cys Thr Glu Tyr 
        435                 440                 445             


Ala Ile Asn Lys Leu Arg Gln Glu Gly Ser Glu Glu Gly Met Tyr Val 
    450                 455                 460                 


Leu Arg Trp Ser Cys Thr Asp Phe Asp Asn Ile Leu Met Thr Val Thr 
465                 470                 475                 480 


Cys Phe Glu Lys Ser Glu Gln Val Gln Gly Ala Gln Lys Gln Phe Lys 
                485                 490                 495     


Asn Phe Gln Ile Glu Val Gln Lys Gly Arg Tyr Ser Leu His Gly Ser 
            500                 505                 510         


Asp Arg Ser Phe Pro Ser Leu Gly Asp Leu Met Ser His Leu Lys Lys 
        515                 520                 525             


Gln Ile Leu Arg Thr Asp Asn Ile Ser Phe Met Leu Lys Arg Cys Cys 
    530                 535                 540                 


Gln Pro Lys Pro Arg Glu Ile Ser Asn Leu Leu Val Ala Thr Lys Lys 
545                 550                 555                 560 


Ala Gln Glu Trp Gln Pro Val Tyr Pro Met Ser Gln Leu Ser Phe Asp 
                565                 570                 575     


Arg Ile Leu Lys Lys Asp Leu Val Gln Gly Glu His Leu Gly Arg Gly 
            580                 585                 590         


Thr Arg Thr His Ile Tyr Ser Gly Thr Leu Met Asp Tyr Lys Asp Asp 
        595                 600                 605             


Glu Gly Thr Ser Glu Glu Lys Lys Ile Lys Val Ile Leu Lys Val Leu 
    610                 615                 620                 


Asp Pro Ser His Arg Asp Ile Ser Leu Ala Phe Phe Glu Ala Ala Ser 
625                 630                 635                 640 


Met Met Arg Gln Val Ser His Lys His Ile Val Tyr Leu Tyr Gly Val 
                645                 650                 655     


Cys Val Arg Asp Val Glu Asn Ile Met Val Glu Glu Phe Val Glu Gly 
            660                 665                 670         


Gly Pro Leu Asp Leu Phe Met His Arg Lys Ser Asp Val Leu Thr Thr 
        675                 680                 685             


Pro Trp Lys Phe Lys Val Ala Lys Gln Leu Ala Ser Ala Leu Ser Tyr 
    690                 695                 700                 


Leu Glu Asp Lys Asp Leu Val His Gly Asn Val Cys Thr Lys Asn Leu 
705                 710                 715                 720 


Leu Leu Ala Arg Glu Gly Ile Asp Ser Glu Cys Gly Pro Phe Ile Lys 
                725                 730                 735     


Leu Ser Asp Pro Gly Ile Pro Ile Thr Val Leu Ser Arg Gln Glu Cys 
            740                 745                 750         


Ile Glu Arg Ile Pro Trp Ile Ala Pro Glu Cys Val Glu Asp Ser Lys 
        755                 760                 765             


Asn Leu Ser Val Ala Ala Asp Lys Trp Ser Phe Gly Thr Thr Leu Trp 
    770                 775                 780                 


Glu Ile Cys Tyr Asn Gly Glu Ile Pro Leu Lys Asp Lys Thr Leu Ile 
785                 790                 795                 800 


Glu Lys Glu Arg Phe Tyr Glu Ser Arg Cys Arg Pro Val Thr Pro Ser 
                805                 810                 815     


Cys Lys Glu Leu Ala Asp Leu Met Thr Arg Cys Met Asn Tyr Asp Pro 
            820                 825                 830         


Asn Gln Arg Pro Phe Phe Arg Ala Ile Met Arg Asp Ile Asn Lys Leu 
        835                 840                 845             


Glu Glu Gln Asn Ile Val Ser Glu Lys Lys Pro Ala Thr Glu Val Asp 
    850                 855                 860                 


Pro Thr His Phe Glu Lys Arg Phe Leu Lys Arg Ile Arg Asp Leu Gly 
865                 870                 875                 880 


Glu Gly His Phe Gly Lys Val Glu Leu Cys Arg Tyr Asp Pro Glu Gly 
                885                 890                 895     


Asp Asn Thr Gly Glu Gln Val Ala Val Lys Ser Leu Lys Pro Glu Ser 
            900                 905                 910         


Gly Gly Asn His Ile Ala Asp Leu Lys Lys Glu Ile Glu Ile Leu Arg 
        915                 920                 925             


Asn Leu Tyr His Glu Asn Ile Val Lys Tyr Lys Gly Ile Cys Thr Glu 
    930                 935                 940                 


Asp Gly Gly Asn Gly Ile Lys Leu Ile Met Glu Phe Leu Pro Ser Gly 
945                 950                 955                 960 


Ser Leu Lys Glu Tyr Leu Pro Lys Asn Lys Asn Lys Ile Asn Leu Lys 
                965                 970                 975     


Gln Gln Leu Lys Tyr Ala Val Gln Ile Cys Lys Gly Met Asp Tyr Leu 
            980                 985                 990         


Gly Ser Arg Gln Tyr Val His Arg  Asp Leu Ala Ala Arg  Asn Val Leu 
        995                 1000                 1005             


Val Glu  Ser Glu His Gln Val  Lys Ile Gly Asp Phe  Gly Leu Thr 
    1010                 1015                 1020             


Lys Ala  Ile Glu Thr Asp Lys  Glu Tyr Tyr Thr Val  Lys Asp Asp 
    1025                 1030                 1035             


Arg Asp  Ser Pro Val Phe Trp  Tyr Ala Pro Glu Cys  Leu Met Gln 
    1040                 1045                 1050             


Ser Lys  Phe Tyr Ile Ala Ser  Asp Val Trp Ser Phe  Gly Val Thr 
    1055                 1060                 1065             


Leu His  Glu Leu Leu Thr Tyr  Cys Asp Ser Asp Ser  Ser Pro Met 
    1070                 1075                 1080             


Ala Leu  Phe Leu Lys Met Ile  Gly Pro Thr His Gly  Gln Met Thr 
    1085                 1090                 1095             


Val Thr  Arg Leu Val Asn Thr  Leu Lys Glu Gly Lys  Arg Leu Pro 
    1100                 1105                 1110             


Cys Pro  Pro Asn Cys Pro Asp  Glu Val Tyr Gln Leu  Met Arg Lys 
    1115                 1120                 1125             


Cys Trp  Glu Phe Gln Pro Ser  Asn Arg Thr Ser Phe  Gln Asn Leu 
    1130                 1135                 1140             


Ile Glu  Gly Phe Glu Ala Leu  Leu Lys 
    1145                 1150         


<210>  348
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  348

Met Gln Tyr Leu Asn Ile Lys Glu Asp Cys Asn Ala Met Ala Phe Cys 
1               5                   10                  15      


Ala Lys Met Arg Ser Ser Lys Lys Thr Glu Val Asn Leu Glu Ala Pro 
            20                  25                  30          


Glu Pro Gly Val Glu Val Ile Phe Tyr Leu Ser Asp Arg Glu Pro Leu 
        35                  40                  45              


Arg Leu Gly Ser Gly Glu Tyr Thr Ala Glu Glu Leu Cys Ile Arg Ala 
    50                  55                  60                  


Ala Gln Ala Cys Gln Trp Leu Leu Ser Ala Pro Ser Leu Met Asn Tyr 
65                  70                  75                  80  


Lys Ile Pro Gly Asp Asp Ala 
                85          


<210>  349
<211>  468
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  349

Xaa Leu Tyr Gly Val Cys Val Arg Asp Val Glu Asn Ile Met Val Glu 
1               5                   10                  15      


Glu Phe Val Glu Gly Gly Pro Leu Asp Leu Phe Met His Arg Lys Ser 
            20                  25                  30          


Asp Val Leu Thr Thr Pro Trp Lys Phe Lys Val Ala Lys Gln Leu Ala 
        35                  40                  45              


Ser Ala Leu Ser Tyr Leu Glu Asp Lys Asp Leu Val His Gly Asn Val 
    50                  55                  60                  


Cys Thr Lys Asn Leu Leu Leu Ala Arg Glu Gly Ile Asp Ser Glu Cys 
65                  70                  75                  80  


Gly Pro Phe Ile Lys Leu Ser Asp Pro Gly Ile Pro Ile Thr Val Leu 
                85                  90                  95      


Ser Arg Gln Glu Cys Ile Glu Arg Ile Pro Trp Ile Ala Pro Glu Cys 
            100                 105                 110         


Val Glu Asp Ser Lys Asn Leu Ser Val Ala Ala Asp Lys Trp Ser Phe 
        115                 120                 125             


Gly Thr Thr Leu Trp Glu Ile Cys Tyr Asn Gly Glu Ile Pro Leu Lys 
    130                 135                 140                 


Asp Lys Thr Leu Ile Glu Lys Glu Arg Phe Tyr Glu Ser Arg Cys Arg 
145                 150                 155                 160 


Pro Val Thr Pro Ser Tyr Pro Asp Ile Val Ser Glu Lys Lys Pro Ala 
                165                 170                 175     


Thr Glu Val Asp Pro Thr His Phe Glu Lys Arg Phe Leu Lys Arg Ile 
            180                 185                 190         


Arg Asp Leu Gly Glu Gly His Phe Gly Lys Val Glu Leu Cys Arg Tyr 
        195                 200                 205             


Asp Pro Glu Gly Asp Asn Thr Gly Glu Gln Val Ala Val Lys Ser Leu 
    210                 215                 220                 


Lys Pro Glu Ser Gly Gly Asn His Ile Ala Asp Leu Lys Lys Glu Ile 
225                 230                 235                 240 


Glu Ile Leu Arg Asn Leu Tyr His Glu Asn Ile Val Lys Tyr Lys Gly 
                245                 250                 255     


Ile Cys Thr Glu Asp Gly Gly Asn Gly Ile Lys Leu Ile Met Glu Phe 
            260                 265                 270         


Leu Pro Ser Gly Ser Leu Lys Glu Tyr Leu Pro Lys Asn Lys Asn Lys 
        275                 280                 285             


Ile Asn Leu Lys Gln Gln Leu Lys Tyr Ala Val Gln Ile Cys Lys Gly 
    290                 295                 300                 


Met Asp Tyr Leu Gly Ser Arg Gln Tyr Val His Arg Asp Leu Ala Ala 
305                 310                 315                 320 


Arg Asn Val Leu Val Glu Ser Glu His Gln Val Lys Ile Gly Asp Phe 
                325                 330                 335     


Gly Leu Thr Lys Ala Ile Glu Thr Asp Lys Glu Tyr Tyr Thr Val Lys 
            340                 345                 350         


Asp Asp Arg Asp Ser Pro Val Phe Trp Tyr Ala Pro Glu Cys Leu Met 
        355                 360                 365             


Gln Ser Lys Phe Tyr Ile Ala Ser Asp Val Trp Ser Phe Gly Val Thr 
    370                 375                 380                 


Leu His Glu Leu Leu Thr Tyr Cys Asp Ser Asp Ser Ser Pro Met Ala 
385                 390                 395                 400 


Leu Phe Leu Lys Met Ile Gly Pro Thr His Gly Gln Met Thr Val Thr 
                405                 410                 415     


Arg Leu Val Asn Thr Leu Lys Glu Gly Lys Arg Leu Pro Cys Pro Pro 
            420                 425                 430         


Asn Cys Pro Asp Glu Val Tyr Gln Leu Met Arg Lys Cys Trp Glu Phe 
        435                 440                 445             


Gln Pro Ser Asn Arg Thr Ser Phe Gln Asn Leu Ile Glu Gly Phe Glu 
    450                 455                 460                 


Ala Leu Leu Lys 
465             


<210>  350
<211>  1110
<212>  PRT
<213>  Homo sapiens

<400>  350

Met Gln Tyr Leu Asn Ile Lys Glu Asp Cys Asn Ala Met Ala Phe Cys 
1               5                   10                  15      


Ala Lys Met Arg Ser Ser Lys Lys Thr Glu Val Asn Leu Glu Ala Pro 
            20                  25                  30          


Glu Pro Gly Val Glu Val Ile Phe Tyr Leu Ser Asp Arg Glu Pro Leu 
        35                  40                  45              


Arg Leu Gly Ser Gly Glu Tyr Thr Ala Glu Glu Leu Cys Ile Arg Ala 
    50                  55                  60                  


Ala Gln Ala Cys Arg Ile Ser Pro Leu Cys His Asn Leu Phe Ala Leu 
65                  70                  75                  80  


Tyr Asp Glu Asn Thr Lys Leu Trp Tyr Ala Pro Asn Arg Thr Ile Thr 
                85                  90                  95      


Val Asp Asp Lys Met Ser Leu Arg Leu His Tyr Arg Met Arg Phe Tyr 
            100                 105                 110         


Phe Thr Asn Trp His Gly Thr Asn Asp Asn Glu Gln Ser Val Trp Arg 
        115                 120                 125             


His Ser Pro Lys Lys Gln Lys Asn Gly Tyr Glu Lys Lys Lys Ile Pro 
    130                 135                 140                 


Asp Ala Thr Pro Leu Leu Asp Ala Ser Ser Leu Glu Tyr Leu Phe Ala 
145                 150                 155                 160 


Gln Gly Gln Tyr Asp Leu Val Lys Cys Leu Ala Pro Ile Arg Asp Pro 
                165                 170                 175     


Lys Thr Glu Gln Asp Gly His Asp Ile Glu Asn Glu Cys Leu Gly Met 
            180                 185                 190         


Ala Val Leu Ala Ile Ser His Tyr Ala Met Met Lys Lys Met Gln Leu 
        195                 200                 205             


Pro Glu Leu Pro Lys Asp Ile Ser Val Ser Thr His Asp Leu Lys Val 
    210                 215                 220                 


Lys Tyr Leu Ala Thr Leu Glu Thr Leu Thr Lys His Tyr Gly Ala Glu 
225                 230                 235                 240 


Ile Phe Glu Thr Ser Met Leu Leu Ile Ser Ser Glu Asn Glu Met Asn 
                245                 250                 255     


Trp Phe His Ser Asn Asp Gly Gly Asn Val Leu Tyr Tyr Glu Val Met 
            260                 265                 270         


Val Thr Gly Asn Leu Gly Ile Gln Trp Arg His Lys Pro Asn Val Val 
        275                 280                 285             


Ser Val Glu Lys Glu Lys Asn Lys Leu Lys Arg Lys Lys Leu Glu Asn 
    290                 295                 300                 


Lys His Lys Lys Asp Glu Glu Lys Asn Lys Ile Arg Glu Glu Trp Asn 
305                 310                 315                 320 


Asn Phe Ser Tyr Phe Pro Glu Ile Thr His Ile Val Ile Lys Glu Ser 
                325                 330                 335     


Val Val Ser Ile Asn Lys Gln Asp Asn Lys Lys Met Glu Leu Lys Leu 
            340                 345                 350         


Ser Ser His Glu Glu Ala Leu Ser Phe Val Ser Leu Val Asp Gly Tyr 
        355                 360                 365             


Phe Arg Leu Thr Ala Asp Ala His His Tyr Leu Cys Thr Asp Val Ala 
    370                 375                 380                 


Pro Pro Leu Ile Val His Asn Ile Gln Asn Gly Cys His Gly Pro Ile 
385                 390                 395                 400 


Cys Thr Glu Tyr Ala Ile Asn Lys Leu Arg Gln Glu Gly Ser Glu Glu 
                405                 410                 415     


Gly Met Tyr Val Leu Arg Trp Ser Cys Thr Asp Phe Asp Asn Ile Leu 
            420                 425                 430         


Met Thr Val Thr Cys Phe Glu Lys Ser Glu Gln Val Gln Gly Ala Gln 
        435                 440                 445             


Lys Gln Phe Lys Asn Phe Gln Ile Glu Val Gln Lys Gly Arg Tyr Ser 
    450                 455                 460                 


Leu His Gly Ser Asp Arg Ser Phe Pro Ser Leu Gly Asp Leu Met Ser 
465                 470                 475                 480 


His Leu Lys Lys Gln Ile Leu Arg Thr Asp Asn Ile Ser Phe Met Leu 
                485                 490                 495     


Lys Arg Cys Cys Gln Pro Lys Pro Arg Glu Ile Ser Asn Leu Leu Val 
            500                 505                 510         


Ala Thr Lys Lys Ala Gln Glu Trp Gln Pro Val Tyr Pro Met Ser Gln 
        515                 520                 525             


Leu Ser Phe Asp Arg Ile Leu Lys Lys Asp Leu Val Gln Gly Glu His 
    530                 535                 540                 


Leu Gly Arg Gly Thr Arg Thr His Ile Tyr Ser Gly Thr Leu Met Asp 
545                 550                 555                 560 


Tyr Lys Asp Asp Glu Gly Thr Ser Glu Glu Lys Lys Ile Lys Val Ile 
                565                 570                 575     


Leu Lys Val Leu Asp Pro Ser His Arg Asp Ile Ser Leu Ala Phe Phe 
            580                 585                 590         


Glu Ala Ala Ser Met Met Arg Gln Val Ser His Lys His Ile Val Tyr 
        595                 600                 605             


Leu Tyr Gly Val Cys Val Arg Asp Val Glu Asn Ile Met Val Glu Glu 
    610                 615                 620                 


Phe Val Glu Gly Gly Pro Leu Asp Leu Phe Met His Arg Lys Ser Asp 
625                 630                 635                 640 


Val Leu Thr Thr Pro Trp Lys Phe Lys Val Ala Lys Gln Leu Ala Ser 
                645                 650                 655     


Ala Leu Ser Tyr Leu Glu Asp Lys Asp Leu Val His Gly Asn Val Cys 
            660                 665                 670         


Thr Lys Asn Leu Leu Leu Ala Arg Glu Gly Ile Asp Ser Glu Cys Gly 
        675                 680                 685             


Pro Phe Ile Lys Leu Ser Asp Pro Gly Ile Pro Ile Thr Val Leu Ser 
    690                 695                 700                 


Arg Gln Glu Cys Ile Glu Arg Ile Pro Trp Ile Ala Pro Glu Cys Val 
705                 710                 715                 720 


Glu Asp Ser Lys Asn Leu Ser Val Ala Ala Asp Lys Trp Ser Phe Gly 
                725                 730                 735     


Thr Thr Leu Trp Glu Ile Cys Tyr Asn Gly Glu Ile Pro Leu Lys Asp 
            740                 745                 750         


Lys Thr Leu Ile Glu Lys Glu Arg Phe Tyr Glu Ser Arg Cys Arg Pro 
        755                 760                 765             


Val Thr Pro Ser Cys Lys Glu Leu Ala Asp Leu Met Thr Arg Cys Met 
    770                 775                 780                 


Asn Tyr Asp Pro Asn Gln Arg Pro Phe Phe Arg Ala Ile Met Arg Asp 
785                 790                 795                 800 


Ile Asn Lys Leu Glu Glu Gln Asn Pro Asp Ile Val Ser Glu Lys Lys 
                805                 810                 815     


Pro Ala Thr Glu Val Asp Pro Thr His Phe Glu Lys Arg Phe Leu Lys 
            820                 825                 830         


Arg Ile Arg Asp Leu Gly Glu Gly His Phe Gly Lys Val Glu Leu Cys 
        835                 840                 845             


Arg Tyr Asp Pro Glu Gly Asp Asn Thr Gly Glu Gln Val Ala Val Lys 
    850                 855                 860                 


Ser Leu Lys Pro Glu Ser Gly Gly Asn His Ile Ala Asp Leu Lys Lys 
865                 870                 875                 880 


Glu Ile Glu Ile Leu Arg Asn Leu Tyr His Glu Asn Ile Val Lys Tyr 
                885                 890                 895     


Lys Gly Ile Cys Thr Glu Asp Gly Gly Asn Gly Ile Lys Leu Ile Met 
            900                 905                 910         


Glu Phe Leu Pro Ser Gly Ser Leu Lys Glu Tyr Leu Pro Lys Asn Lys 
        915                 920                 925             


Asn Lys Ile Asn Leu Lys Gln Gln Leu Lys Tyr Ala Val Gln Ile Cys 
    930                 935                 940                 


Lys Gly Met Asp Tyr Leu Gly Ser Arg Gln Tyr Val His Arg Asp Leu 
945                 950                 955                 960 


Ala Ala Arg Asn Val Leu Val Glu Ser Glu His Gln Val Lys Ile Gly 
                965                 970                 975     


Asp Phe Gly Leu Thr Lys Ala Ile Glu Thr Asp Lys Glu Tyr Tyr Thr 
            980                 985                 990         


Val Lys Asp Asp Arg Asp Ser Pro  Val Phe Trp Tyr Ala  Pro Glu Cys 
        995                 1000                 1005             


Leu Met  Gln Ser Lys Phe Tyr  Ile Ala Ser Asp Val  Trp Ser Phe 
    1010                 1015                 1020             


Gly Val  Thr Leu His Glu Leu  Leu Thr Tyr Cys Asp  Ser Asp Ser 
    1025                 1030                 1035             


Ser Pro  Met Ala Leu Phe Leu  Lys Met Ile Gly Pro  Thr His Gly 
    1040                 1045                 1050             


Gln Met  Thr Val Thr Arg Leu  Val Asn Thr Leu Lys  Glu Gly Lys 
    1055                 1060                 1065             


Arg Leu  Pro Cys Pro Pro Asn  Cys Pro Asp Glu Val  Tyr Gln Leu 
    1070                 1075                 1080             


Met Arg  Lys Cys Trp Glu Phe  Gln Pro Ser Asn Arg  Thr Ser Phe 
    1085                 1090                 1095             


Gln Asn  Leu Ile Glu Gly Phe  Glu Ala Leu Leu Lys  
    1100                 1105                 1110 


<210>  351
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  351

Met Gln Tyr Leu Asn Ile Lys Glu Asp Cys Asn Ala Met Ala Phe Cys 
1               5                   10                  15      


Ala Lys Met Arg Ser Ser Lys Lys Thr Glu Val Asn Leu Glu Ala Pro 
            20                  25                  30          


Glu Pro Gly Val Glu Val Ile Phe Tyr Leu Ser Asp Arg Glu Pro Leu 
        35                  40                  45              


Arg Leu Gly Ser Gly Glu Tyr Thr Ala Glu Glu Leu Cys Ile Arg Ala 
    50                  55                  60                  


Ala Gln Ala Cys Arg Ile Ser Pro Leu Cys His Asn Leu Phe Ala Leu 
65                  70                  75                  80  


Tyr Asp Glu Asn Thr Lys Leu Trp Tyr Ala Pro Asn Arg Thr Ile Thr 
                85                  90                  95      


Val Asp Asp Lys Met Ser Leu Arg Leu His Tyr Arg Met Arg Phe Tyr 
            100                 105                 110         


Phe Thr Asn Trp His Gly Thr Asn Asp Asn Glu Gln Ser Val Trp Arg 
        115                 120                 125             


His Ser Pro 
    130     


<210>  352
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  352

Met Gln Tyr Leu Asn Ile Lys Glu Asp Cys Asn Ala Met Ala Phe Cys 
1               5                   10                  15      


Ala Lys Met Arg Ser Ser Lys Lys Thr Glu Val Asn Leu Glu Ala Pro 
            20                  25                  30          


Glu Pro Gly Val Glu Val Ile Phe Tyr Leu Ser Asp Arg Glu Pro Leu 
        35                  40                  45              


Arg Leu Gly Ser Gly Glu Tyr Thr Ala Glu Glu Leu Cys Ile Arg Ala 
    50                  55                  60                  


Ala Gln Ala Cys Arg Ile Ser Pro Leu Cys His Asn Leu Phe Ala Leu 
65                  70                  75                  80  


Tyr Asp Glu Asn Thr Lys Leu Trp Tyr Ala Pro Asn Arg Thr Ile Thr 
                85                  90                  95      


Val Asp Asp Lys Met Ser Leu Arg Leu His Tyr Arg Met Arg Phe Tyr 
            100                 105                 110         


Phe Thr Asn Trp His Gly Thr Asn Asp Asn Glu Gln Ser Val Trp Arg 
        115                 120                 125             


His Ser Pro Lys Lys Gln Lys Asn Gly Tyr Glu Lys Lys Lys Ile Pro 
    130                 135                 140                 


Asp Ala Thr Pro Leu Leu Asp Ala Ser Ser Leu Glu Tyr Leu Phe Ala 
145                 150                 155                 160 


Gln Gly Gln Tyr Asp Leu Val Lys Cys Leu Ala Pro Ile Arg Asp Pro 
                165                 170                 175     


Lys Thr Glu Gln Asp Gly His Asp Ile Glu Asn Glu Cys Leu Gly Met 
            180                 185                 190         


Ala Val Leu Ala Ile Ser His Tyr Ala Met Met Lys Lys Met Gln Leu 
        195                 200                 205             


Pro Glu Leu Pro Lys Asp Ile Ser Tyr Lys Arg Tyr Ile Pro Glu Thr 
    210                 215                 220                 


Leu Asn Lys Ser Ile Arg Gln Arg Asn Leu Leu Thr Arg Met Arg Ile 
225                 230                 235                 240 


Asn Asn Val Phe Lys Asp Phe Leu Lys Glu Phe Asn Asn Lys Thr Ile 
                245                 250                 255     


Cys Asp Ser Ser Val Ser Thr His Asp Leu Lys Val Lys Tyr Leu Ala 
            260                 265                 270         


Thr Leu Glu Thr Leu Thr Lys His Tyr Gly Ala Glu Ile Phe Glu Thr 
        275                 280                 285             


Ser Met Leu Leu Ile Ser Ser Glu Asn Glu Met Asn Trp Phe His Ser 
    290                 295                 300                 


Asn Asp Gly Gly Asn Val Leu Tyr Tyr Glu Val Met Val Thr Gly Asn 
305                 310                 315                 320 


Leu Gly Ile Gln Trp Arg His Lys Pro Asn Val Val Ser Val Glu Lys 
                325                 330                 335     


Glu Lys Asn Lys Leu Lys Arg Lys Lys 
            340                 345 


<210>  353
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  353

Met Gln Tyr Leu Asn Ile Lys Glu Asp Cys Asn Ala Met Ala Phe Cys 
1               5                   10                  15      


Ala Lys Met Arg Ser Ser Lys Lys Thr Glu Val Asn Leu Glu Ala Pro 
            20                  25                  30          


Glu Pro Gly Val Glu Val Ile Phe Tyr Leu Ser Asp Arg Glu Pro Leu 
        35                  40                  45              


Arg Leu Gly Ser Gly Glu Tyr Thr Ala Glu Glu Leu Cys Ile Arg Ala 
    50                  55                  60                  


Ala Gln Ala Cys Arg Ile Ser Pro Leu Cys His Asn Leu Phe Ala Leu 
65                  70                  75                  80  


Tyr Asp Glu Asn Thr Lys Leu Trp Tyr Ala Pro Asn Arg Thr Ile Thr 
                85                  90                  95      


Val Asp Asp Lys Met Ser Leu Arg Leu His Tyr Arg Met Ser Leu Cys 
            100                 105                 110         


Ser Ser Gly Glu Ala Thr His Tyr Val Trp Ser Pro Gln Pro Asp Ala 
        115                 120                 125             


Val 
    


<210>  354
<211>  993
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  354

Xaa Asn Asp Asn Glu Gln Ser Val Trp Arg His Ser Pro Lys Lys Gln 
1               5                   10                  15      


Lys Asn Gly Tyr Glu Lys Lys Lys Ile Pro Asp Ala Thr Pro Leu Leu 
            20                  25                  30          


Asp Ala Ser Ser Leu Glu Tyr Leu Phe Ala Gln Gly Gln Tyr Asp Leu 
        35                  40                  45              


Val Lys Cys Leu Ala Pro Ile Arg Asp Pro Lys Thr Glu Gln Asp Gly 
    50                  55                  60                  


His Asp Ile Glu Asn Glu Cys Leu Gly Met Ala Val Leu Ala Ile Ser 
65                  70                  75                  80  


His Tyr Ala Met Met Lys Lys Met Gln Leu Pro Glu Leu Pro Lys Asp 
                85                  90                  95      


Ile Ser Ser Val Ser Thr His Asp Leu Lys Val Lys Tyr Leu Ala Thr 
            100                 105                 110         


Leu Glu Thr Leu Thr Lys His Tyr Gly Ala Glu Ile Phe Glu Thr Ser 
        115                 120                 125             


Met Leu Leu Ile Ser Ser Glu Asn Glu Met Asn Trp Phe His Ser Asn 
    130                 135                 140                 


Asp Gly Gly Asn Val Leu Tyr Tyr Glu Val Met Val Thr Gly Asn Leu 
145                 150                 155                 160 


Gly Ile Gln Trp Arg His Lys Pro Asn Val Val Ser Val Glu Lys Glu 
                165                 170                 175     


Lys Asn Lys Leu Lys Arg Lys Lys Leu Glu Asn Lys His Lys Lys Asp 
            180                 185                 190         


Glu Glu Lys Asn Lys Ile Arg Glu Glu Trp Asn Asn Phe Ser Tyr Phe 
        195                 200                 205             


Pro Glu Ile Thr His Ile Val Ile Lys Glu Ser Val Val Ser Ile Asn 
    210                 215                 220                 


Lys Gln Asp Asn Lys Lys Met Glu Leu Lys Leu Ser Ser His Glu Glu 
225                 230                 235                 240 


Ala Leu Ser Phe Val Ser Leu Val Asp Gly Tyr Phe Arg Leu Thr Ala 
                245                 250                 255     


Asp Ala His His Tyr Leu Cys Thr Asp Val Ala Pro Pro Leu Ile Val 
            260                 265                 270         


His Asn Ile Gln Asn Gly Cys His Gly Pro Ile Cys Thr Glu Tyr Ala 
        275                 280                 285             


Ile Asn Lys Leu Arg Gln Glu Gly Ser Glu Glu Gly Met Tyr Val Leu 
    290                 295                 300                 


Arg Trp Ser Cys Thr Asp Phe Asp Asn Ile Leu Met Thr Val Thr Cys 
305                 310                 315                 320 


Phe Glu Lys Ser Glu Gln Val Gln Gly Ala Gln Lys Gln Phe Lys Asn 
                325                 330                 335     


Phe Gln Ile Glu Val Gln Lys Gly Arg Tyr Ser Leu His Gly Ser Asp 
            340                 345                 350         


Arg Ser Phe Pro Ser Leu Gly Asp Leu Met Ser His Leu Lys Lys Gln 
        355                 360                 365             


Ile Leu Arg Thr Asp Asn Ile Ser Phe Met Leu Lys Arg Cys Cys Gln 
    370                 375                 380                 


Pro Lys Pro Arg Glu Ile Ser Asn Leu Leu Val Ala Thr Lys Lys Ala 
385                 390                 395                 400 


Gln Glu Trp Gln Pro Val Tyr Pro Met Ser Gln Leu Ser Phe Asp Arg 
                405                 410                 415     


Ile Leu Lys Lys Asp Leu Val Gln Gly Glu His Leu Gly Arg Gly Thr 
            420                 425                 430         


Arg Thr His Ile Tyr Ser Gly Thr Leu Met Asp Tyr Lys Asp Asp Glu 
        435                 440                 445             


Gly Thr Ser Glu Glu Lys Lys Ile Lys Val Ile Leu Lys Val Leu Asp 
    450                 455                 460                 


Pro Ser His Arg Asp Ile Ser Leu Ala Phe Phe Glu Ala Ala Ser Met 
465                 470                 475                 480 


Met Arg Gln Val Ser His Lys His Ile Val Tyr Leu Tyr Gly Val Cys 
                485                 490                 495     


Val Arg Asp Val Glu Asn Ile Met Val Glu Glu Phe Val Glu Gly Gly 
            500                 505                 510         


Pro Leu Asp Leu Phe Met His Arg Lys Ser Asp Val Leu Thr Thr Pro 
        515                 520                 525             


Trp Lys Phe Lys Val Ala Lys Gln Leu Ala Ser Ala Leu Ser Tyr Leu 
    530                 535                 540                 


Glu Asp Lys Asp Leu Val His Gly Asn Val Cys Thr Lys Asn Leu Leu 
545                 550                 555                 560 


Leu Ala Arg Glu Gly Ile Asp Ser Glu Cys Gly Pro Phe Ile Lys Leu 
                565                 570                 575     


Ser Asp Pro Gly Ile Pro Ile Thr Val Leu Ser Arg Gln Glu Cys Ile 
            580                 585                 590         


Glu Arg Ile Pro Trp Ile Ala Pro Glu Cys Val Glu Asp Ser Lys Asn 
        595                 600                 605             


Leu Ser Val Ala Ala Asp Lys Trp Ser Phe Gly Thr Thr Leu Trp Glu 
    610                 615                 620                 


Ile Cys Tyr Asn Gly Glu Ile Pro Leu Lys Asp Lys Thr Leu Ile Glu 
625                 630                 635                 640 


Lys Glu Arg Phe Tyr Glu Ser Arg Cys Arg Pro Val Thr Pro Ser Cys 
                645                 650                 655     


Lys Glu Leu Ala Asp Leu Met Thr Arg Cys Met Asn Tyr Asp Pro Asn 
            660                 665                 670         


Gln Arg Pro Phe Phe Arg Ala Ile Met Arg Asp Ile Asn Lys Leu Glu 
        675                 680                 685             


Glu Gln Asn Pro Asp Ile Val Ser Glu Lys Lys Pro Ala Thr Glu Val 
    690                 695                 700                 


Asp Pro Thr His Phe Glu Lys Arg Phe Leu Lys Arg Ile Arg Asp Leu 
705                 710                 715                 720 


Gly Glu Gly His Phe Gly Lys Val Glu Leu Cys Arg Tyr Asp Pro Glu 
                725                 730                 735     


Gly Asp Asn Thr Gly Glu Gln Val Ala Val Lys Ser Leu Lys Pro Glu 
            740                 745                 750         


Ser Gly Gly Asn His Ile Ala Asp Leu Lys Lys Glu Ile Glu Ile Leu 
        755                 760                 765             


Arg Asn Leu Tyr His Glu Asn Ile Val Lys Tyr Lys Gly Ile Cys Thr 
    770                 775                 780                 


Glu Asp Gly Gly Asn Gly Ile Lys Leu Ile Met Glu Phe Leu Pro Ser 
785                 790                 795                 800 


Gly Ser Leu Lys Glu Tyr Leu Pro Lys Asn Lys Asn Lys Ile Asn Leu 
                805                 810                 815     


Lys Gln Gln Leu Lys Tyr Ala Val Gln Ile Cys Lys Gly Met Asp Tyr 
            820                 825                 830         


Leu Gly Ser Arg Gln Tyr Val His Arg Asp Leu Ala Ala Arg Asn Val 
        835                 840                 845             


Leu Val Glu Ser Glu His Gln Val Lys Ile Gly Asp Phe Gly Leu Thr 
    850                 855                 860                 


Lys Ala Ile Glu Thr Asp Lys Glu Tyr Tyr Thr Val Lys Asp Asp Arg 
865                 870                 875                 880 


Asp Ser Pro Val Phe Trp Tyr Ala Pro Glu Cys Leu Met Gln Ser Lys 
                885                 890                 895     


Phe Tyr Ile Ala Ser Asp Val Trp Ser Phe Gly Val Thr Leu His Glu 
            900                 905                 910         


Leu Leu Thr Tyr Cys Asp Ser Asp Ser Ser Pro Met Ala Leu Phe Leu 
        915                 920                 925             


Lys Met Ile Gly Pro Thr His Gly Gln Met Thr Val Thr Arg Leu Val 
    930                 935                 940                 


Asn Thr Leu Lys Glu Gly Lys Arg Leu Pro Cys Pro Pro Asn Cys Pro 
945                 950                 955                 960 


Asp Glu Val Tyr Gln Leu Met Arg Lys Cys Trp Glu Phe Gln Pro Ser 
                965                 970                 975     


Asn Arg Thr Ser Phe Gln Asn Leu Ile Glu Gly Phe Glu Ala Leu Leu 
            980                 985                 990         


Lys 
    


<210>  355
<211>  803
<212>  PRT
<213>  Homo sapiens

<400>  355

Met Ile Pro Val Thr Glu Phe Arg Gln Phe Ser Glu Gln Gln Pro Ala 
1               5                   10                  15      


Phe Arg Val Leu Lys Pro Trp Trp Asp Val Phe Thr Asp Tyr Leu Ser 
            20                  25                  30          


Val Ala Met Leu Met Ile Gly Val Phe Gly Cys Thr Leu Gln Val Met 
        35                  40                  45              


Gln Asp Lys Ile Ile Cys Leu Pro Lys Arg Val Gln Pro Ala Gln Asn 
    50                  55                  60                  


His Ser Ser Leu Ser Asn Val Ser Gln Ala Val Ala Ser Thr Thr Pro 
65                  70                  75                  80  


Leu Pro Pro Pro Lys Pro Ser Pro Ala Asn Pro Ile Thr Val Glu Met 
                85                  90                  95      


Lys Gly Leu Lys Thr Asp Leu Asp Leu Gln Gln Tyr Ser Phe Ile Asn 
            100                 105                 110         


Gln Met Cys Tyr Glu Arg Ala Leu His Trp Tyr Ala Lys Tyr Phe Pro 
        115                 120                 125             


Tyr Leu Val Leu Ile His Thr Leu Val Phe Met Leu Cys Ser Asn Phe 
    130                 135                 140                 


Trp Phe Lys Phe Pro Gly Ser Ser Ser Lys Ile Glu His Phe Ile Ser 
145                 150                 155                 160 


Ile Leu Gly Lys Cys Phe Asp Ser Pro Trp Thr Thr Arg Ala Leu Ser 
                165                 170                 175     


Glu Val Ser Gly Glu Asp Ser Glu Glu Lys Asp Asn Arg Lys Asn Asn 
            180                 185                 190         


Met Asn Arg Ser Asn Thr Ile Gln Ser Gly Pro Glu Asp Ser Leu Val 
        195                 200                 205             


Asn Ser Gln Ser Leu Lys Ser Ile Pro Glu Lys Phe Val Val Asp Lys 
    210                 215                 220                 


Ser Thr Ala Gly Ala Leu Asp Lys Lys Glu Gly Glu Gln Ala Lys Ala 
225                 230                 235                 240 


Leu Phe Glu Lys Val Lys Lys Phe Arg Leu His Val Glu Glu Gly Asp 
                245                 250                 255     


Ile Leu Tyr Ala Met Tyr Val Arg Gln Thr Val Leu Lys Val Ile Lys 
            260                 265                 270         


Phe Leu Ile Ile Ile Ala Tyr Asn Ser Ala Leu Val Ser Lys Val Gln 
        275                 280                 285             


Phe Thr Val Asp Cys Asn Val Asp Ile Gln Asp Met Thr Gly Tyr Lys 
    290                 295                 300                 


Asn Phe Ser Cys Asn His Thr Met Ala His Leu Phe Ser Lys Leu Ser 
305                 310                 315                 320 


Phe Cys Tyr Leu Cys Phe Val Ser Ile Tyr Gly Leu Thr Cys Leu Tyr 
                325                 330                 335     


Thr Leu Tyr Trp Leu Phe Tyr Arg Ser Leu Arg Glu Tyr Ser Phe Glu 
            340                 345                 350         


Tyr Val Arg Gln Glu Thr Gly Ile Asp Asp Ile Pro Asp Val Lys Asn 
        355                 360                 365             


Asp Phe Ala Phe Met Leu His Met Ile Asp Gln Tyr Asp Pro Leu Tyr 
    370                 375                 380                 


Ser Lys Arg Phe Ala Val Phe Leu Ser Glu Val Ser Glu Asn Lys Leu 
385                 390                 395                 400 


Lys Gln Leu Asn Leu Asn Asn Glu Trp Thr Pro Asp Lys Leu Arg Gln 
                405                 410                 415     


Lys Leu Gln Thr Asn Ala His Asn Arg Leu Glu Leu Pro Leu Ile Met 
            420                 425                 430         


Leu Ser Gly Leu Pro Asp Thr Val Phe Glu Ile Thr Glu Leu Gln Ser 
        435                 440                 445             


Leu Lys Leu Glu Ile Ile Lys Asn Val Met Ile Pro Ala Thr Ile Ala 
    450                 455                 460                 


Gln Leu Asp Asn Leu Gln Glu Leu Ser Leu His Gln Cys Ser Val Lys 
465                 470                 475                 480 


Ile His Ser Ala Ala Leu Ser Phe Leu Lys Glu Asn Leu Lys Val Leu 
                485                 490                 495     


Ser Val Lys Phe Asp Asp Met Arg Glu Leu Pro Pro Trp Met Tyr Gly 
            500                 505                 510         


Leu Arg Asn Leu Glu Glu Leu Tyr Leu Val Gly Ser Leu Ser His Asp 
        515                 520                 525             


Ile Ser Arg Asn Val Thr Leu Glu Ser Leu Arg Asp Leu Lys Ser Leu 
    530                 535                 540                 


Lys Ile Leu Ser Ile Lys Ser Asn Val Ser Lys Ile Pro Gln Ala Val 
545                 550                 555                 560 


Val Asp Val Ser Ser His Leu Gln Lys Met Cys Ile His Asn Asp Gly 
                565                 570                 575     


Thr Lys Leu Val Met Leu Asn Asn Leu Lys Lys Met Thr Asn Leu Thr 
            580                 585                 590         


Glu Leu Glu Leu Val His Cys Asp Leu Glu Arg Ile Pro His Ala Val 
        595                 600                 605             


Phe Ser Leu Leu Ser Leu Gln Glu Leu Asp Leu Lys Glu Asn Asn Leu 
    610                 615                 620                 


Lys Ser Ile Glu Glu Ile Val Ser Phe Gln His Leu Arg Lys Leu Thr 
625                 630                 635                 640 


Val Leu Lys Leu Trp His Asn Ser Ile Thr Tyr Ile Pro Glu His Ile 
                645                 650                 655     


Lys Lys Leu Thr Ser Leu Glu Arg Leu Ser Phe Ser His Asn Lys Ile 
            660                 665                 670         


Glu Val Leu Pro Ser His Leu Phe Leu Cys Asn Lys Ile Arg Tyr Leu 
        675                 680                 685             


Asp Leu Ser Tyr Asn Asp Ile Arg Phe Ile Pro Pro Glu Ile Gly Val 
    690                 695                 700                 


Leu Gln Ser Leu Gln Tyr Phe Ser Ile Thr Cys Asn Lys Val Glu Ser 
705                 710                 715                 720 


Leu Pro Asp Glu Leu Tyr Phe Cys Lys Lys Leu Lys Thr Leu Lys Ile 
                725                 730                 735     


Gly Lys Asn Ser Leu Ser Val Leu Ser Pro Lys Ile Gly Asn Leu Leu 
            740                 745                 750         


Phe Leu Ser Tyr Leu Asp Val Lys Gly Asn His Phe Glu Ile Leu Pro 
        755                 760                 765             


Pro Glu Leu Gly Asp Cys Arg Ala Leu Lys Arg Ala Gly Leu Val Val 
    770                 775                 780                 


Glu Asp Ala Leu Phe Glu Thr Leu Pro Ser Asp Val Arg Glu Gln Met 
785                 790                 795                 800 


Lys Thr Glu 
            


<210>  356
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  356

Met Ile Pro Val Thr Glu Phe Arg Gln Phe Ser Glu Gln Gln Pro Ala 
1               5                   10                  15      


Phe Arg Val Leu Lys Pro Trp Trp Asp Val Phe Thr Asp Tyr Leu Ser 
            20                  25                  30          


Val Ala Met Leu Met Ile Gly Val Phe Gly Cys Thr Leu Gln Ala Val 
        35                  40                  45              


Ser Leu Lys Leu Ser Gly Phe Ile Leu Phe 
    50                  55              


<210>  357
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  357

Met Pro Arg Ser Phe Leu Val Lys Ser Lys Lys Ala His Ser Tyr His 
1               5                   10                  15      


Gln Pro Arg Ser Pro Gly Pro Asp Tyr Ser Leu Arg Leu Glu Asn Val 
            20                  25                  30          


Pro Ala Pro Ser Arg Ala Asp Ser Thr Ser Asn Ala Gly Gly Ala Lys 
        35                  40                  45              


Ala Glu Pro Arg Asp Arg Leu Ser Pro Glu Ser Gln Leu Thr Glu Ala 
    50                  55                  60                  


Pro Asp Arg Ala Ser Ala Ser Pro Asp Ser Cys Glu Gly Ser Val Cys 
65                  70                  75                  80  


Glu Arg Ser Ser Glu Phe Glu Asp Phe Trp Arg Pro Pro Ser Pro Ser 
                85                  90                  95      


Ala Ser Pro Ala Ser Glu Lys Ser Met Cys Pro Ser Leu Asp Glu Ala 
            100                 105                 110         


Gln Pro Phe Pro Leu Pro Phe Lys Pro Tyr Ser Trp Ser Gly Leu Ala 
        115                 120                 125             


Gly Ser Asp Leu Arg His Leu Val Gln Ser Tyr Arg Pro Cys Gly Ala 
    130                 135                 140                 


Leu Glu Arg Gly Ala Gly Leu Gly Leu Phe Cys Glu Pro Ala Pro Glu 
145                 150                 155                 160 


Pro Gly His Pro Ala Ala Leu Tyr Gly Pro Lys Arg Ala Ala Gly Gly 
                165                 170                 175     


Ala Gly Ala Gly Ala Pro Gly Ser Cys Ser Ala Gly Ala Gly Ala Thr 
            180                 185                 190         


Ala Gly Pro Gly Leu Gly Leu Tyr Gly Asp Phe Gly Ser Ala Ala Ala 
        195                 200                 205             


Gly Leu Tyr Glu Arg Pro Thr Ala Ala Ala Gly Leu Leu Tyr Pro Glu 
    210                 215                 220                 


Arg Gly His Gly Leu His Ala Asp Lys Gly Ala Gly Val Lys Val Glu 
225                 230                 235                 240 


Ser Glu Leu Leu Cys Thr Arg Leu Leu Leu Gly Gly Gly Ser Tyr Lys 
                245                 250                 255     


Cys Ile Lys Cys Ser Lys Val Phe Ser Thr Pro His Gly Leu Glu Val 
            260                 265                 270         


His Val Arg Arg Ser His Ser Gly Thr Arg Pro Phe Ala Cys Glu Met 
        275                 280                 285             


Cys Gly Lys Thr Phe Gly His Ala Val Ser Leu Glu Gln His Lys Ala 
    290                 295                 300                 


Val His Ser Gln Glu Arg Ser Phe Asp Cys Lys Ile Cys Gly Lys Ser 
305                 310                 315                 320 


Phe Lys Arg Ser Ser Thr Leu Ser Thr His Leu Leu Ile His Ser Asp 
                325                 330                 335     


Thr Arg Pro Tyr Pro Cys Gln Tyr Cys Gly Lys Arg Phe His Gln Lys 
            340                 345                 350         


Ser Asp Met Lys Lys His Thr Phe Ile His Thr Gly Glu Lys Pro His 
        355                 360                 365             


Lys Cys Gln Val Cys Gly Lys Ala Phe Ser Gln Ser Ser Asn Leu Ile 
    370                 375                 380                 


Thr His Ser Arg Lys His Thr Gly Phe Lys Pro Phe Gly Cys Asp Leu 
385                 390                 395                 400 


Cys Gly Lys Gly Phe Gln Arg Lys Val Asp Leu Arg Arg His Arg Glu 
                405                 410                 415     


Thr Gln His Gly Leu Lys 
            420         


<210>  358
<211>  1004
<212>  PRT
<213>  Homo sapiens

<400>  358

Met Val Gln Leu Tyr Asn Leu His Pro Phe Gly Ser Gln Gln Val Val 
1               5                   10                  15      


Pro Cys Lys Leu Glu Pro Asp Arg Phe Cys Gly Gly Gly Arg Asp Ala 
            20                  25                  30          


Leu Phe Val Ala Ala Gly Cys Lys Val Glu Ala Phe Ala Val Ala Gly 
        35                  40                  45              


Gln Glu Leu Cys Gln Pro Arg Cys Ala Phe Ser Thr Leu Gly Arg Val 
    50                  55                  60                  


Leu Arg Leu Ala Tyr Ser Glu Ala Gly Asp Tyr Leu Val Ala Ile Glu 
65                  70                  75                  80  


Glu Lys Asn Lys Ala Thr Phe Leu Arg Ala Tyr Val Asn Trp Arg Asn 
                85                  90                  95      


Lys Arg Thr Glu Asn Ser Arg Val Cys Ile Arg Met Ile Gly His Asn 
            100                 105                 110         


Val Glu Gly Pro Phe Ser Lys Ala Phe Arg Asp Gln Met Tyr Ile Ile 
        115                 120                 125             


Glu Met Pro Leu Ser Glu Ala Pro Leu Cys Ile Ser Cys Cys Pro Val 
    130                 135                 140                 


Lys Gly Asp Leu Leu Val Gly Cys Thr Asn Lys Leu Val Leu Phe Ser 
145                 150                 155                 160 


Leu Lys Tyr Gln Ile Ile Asn Glu Glu Phe Ser Leu Leu Asp Phe Glu 
                165                 170                 175     


Arg Ser Leu Ile Ile His Ile Asp Asn Ile Thr Pro Val Glu Val Ser 
            180                 185                 190         


Phe Cys Val Gly Tyr Val Ala Val Met Ser Asp Leu Glu Val Leu Ile 
        195                 200                 205             


Val Lys Leu Glu Ser Gly Pro Lys Asn Gly Glu Arg Val His His His 
    210                 215                 220                 


Pro His Lys Thr Asn Asn Arg Ile Arg Arg Thr Glu Glu Gly Ile Ser 
225                 230                 235                 240 


Asn Glu Ile Ser Gln Leu Glu Ser Asp Asp Phe Val Ile Cys Gln Lys 
                245                 250                 255     


Pro Leu Glu Leu Leu Gly Glu Lys Ser Glu Gln Ser Gly Leu Ser Val 
            260                 265                 270         


Thr Leu Glu Ser Thr Gly Leu Ala Asp Glu Lys Arg Lys Tyr Ser His 
        275                 280                 285             


Phe Gln His Leu Leu Tyr Arg Arg Phe Ala Pro Asp Ile Ser Ser Tyr 
    290                 295                 300                 


Val Leu Ser Asp Asp Ile Lys Leu His Ser Leu Gln Leu Leu Pro Ile 
305                 310                 315                 320 


Tyr Gln Thr Gly Ser Leu Thr Ser Asp Gly Lys Asn Leu Ser Gln Glu 
                325                 330                 335     


Lys Glu Leu Leu Ser Leu Phe Cys Phe Phe Ser Leu Pro His Val Gly 
            340                 345                 350         


Tyr Leu Tyr Met Val Val Lys Ser Val Glu Leu Met Ser Val Tyr Gln 
        355                 360                 365             


Tyr Pro Glu Lys Ser Gln Gln Ala Val Leu Thr Pro Gln Phe Leu His 
    370                 375                 380                 


Val Ile Thr Ser Asn Asn Leu Gln Cys Phe Thr Val Arg Cys Ser Ala 
385                 390                 395                 400 


Ala Ala Ala Arg Glu Glu Asp Pro Tyr Met Asp Thr Thr Leu Lys Ala 
                405                 410                 415     


Cys Pro Pro Val Ser Met Asp Val Cys Ala Leu Arg Ile Gln Leu Phe 
            420                 425                 430         


Ile Gly Leu Lys Ala Ile Cys His Phe Lys Asn His Ile Ile Leu Leu 
        435                 440                 445             


Thr Lys Ala Glu Pro Glu Ala Ile Pro Glu Arg Arg Gln Ser Pro Lys 
    450                 455                 460                 


Arg Leu Leu Ser Arg Lys Asp Thr Ser Val Lys Ile Lys Ile Pro Pro 
465                 470                 475                 480 


Val Ala Glu Ala Gly Trp Asn Leu Tyr Ile Val Asn Thr Ile Ser Pro 
                485                 490                 495     


Val Gln Leu Tyr Lys Glu Met Val Asp Tyr Ser Asn Thr Tyr Lys Thr 
            500                 505                 510         


Val Lys Thr Gln Ser Cys Ile His Leu Leu Ser Glu Ala His Leu Leu 
        515                 520                 525             


Val Arg Ala Ala Leu Met Asp Ala Ser Gln Leu Glu Pro Gly Glu Lys 
    530                 535                 540                 


Ala Glu Leu Leu Glu Ala Phe Lys Glu Ser Cys Gly His Leu Gly Asp 
545                 550                 555                 560 


Cys Tyr Ser Arg Leu Asp Ser Gln His Ser His Leu Thr Leu Pro Tyr 
                565                 570                 575     


Tyr Lys Met Ser Gly Leu Ser Met Ala Glu Val Leu Ala Arg Thr Asp 
            580                 585                 590         


Trp Thr Val Glu Asp Gly Leu Gln Lys Tyr Glu Arg Gly Leu Ile Phe 
        595                 600                 605             


Tyr Ile Asn His Ser Leu Tyr Glu Asn Leu Asp Glu Glu Leu Asn Glu 
    610                 615                 620                 


Glu Leu Ala Ala Lys Val Val Gln Met Phe Tyr Val Ala Glu Pro Lys 
625                 630                 635                 640 


Gln Val Pro His Ile Leu Cys Ser Pro Ser Met Lys Asn Ile Asn Pro 
                645                 650                 655     


Leu Thr Ala Met Ser Tyr Leu Arg Lys Leu Asp Thr Ser Gly Phe Ser 
            660                 665                 670         


Ser Ile Leu Val Thr Leu Thr Lys Ala Ala Val Ala Leu Lys Met Gly 
        675                 680                 685             


Asp Leu Asp Met His Arg Asn Glu Met Lys Ser His Ser Glu Met Lys 
    690                 695                 700                 


Leu Val Cys Gly Phe Ile Leu Glu Pro Arg Leu Leu Ile Gln Gln Arg 
705                 710                 715                 720 


Lys Gly Gln Ile Val Pro Thr Glu Leu Ala Leu His Leu Lys Glu Thr 
                725                 730                 735     


Gln Pro Gly Leu Leu Val Ala Ser Val Leu Gly Leu Gln Lys Asn Asn 
            740                 745                 750         


Lys Ile Gly Ile Glu Glu Ala Asp Ser Phe Phe Lys Val Leu Cys Ala 
        755                 760                 765             


Lys Asp Glu Asp Thr Ile Pro Gln Leu Leu Val Asp Phe Trp Glu Ala 
    770                 775                 780                 


Gln Leu Val Ala Cys Leu Pro Asp Val Val Leu Gln Glu Leu Phe Phe 
785                 790                 795                 800 


Lys Leu Thr Ser Gln Tyr Ile Trp Arg Leu Ser Lys Arg Gln Pro Pro 
                805                 810                 815     


Asp Thr Thr Pro Leu Arg Thr Ser Glu Asp Leu Ile Asn Ala Cys Ser 
            820                 825                 830         


His Tyr Gly Leu Ile Tyr Pro Trp Val His Val Val Ile Ser Ser Asp 
        835                 840                 845             


Ser Leu Ala Asp Lys Asn Tyr Thr Glu Asp Leu Ser Lys Leu Gln Ser 
    850                 855                 860                 


Leu Ile Cys Gly Pro Ser Phe Asp Ile Ala Ser Ile Ile Pro Phe Leu 
865                 870                 875                 880 


Glu Pro Leu Ser Glu Asp Thr Ile Ala Gly Leu Ser Val His Val Leu 
                885                 890                 895     


Cys Arg Thr Arg Leu Lys Glu Tyr Glu Gln Cys Ile Asp Ile Leu Leu 
            900                 905                 910         


Glu Arg Cys Pro Glu Ala Val Ile Pro Tyr Ala Asn His Glu Leu Lys 
        915                 920                 925             


Glu Glu Asn Arg Thr Leu Trp Trp Lys Lys Leu Leu Pro Glu Leu Cys 
    930                 935                 940                 


Gln Arg Ile Lys Cys Gly Gly Glu Lys Tyr Gln Leu Tyr Leu Ser Ser 
945                 950                 955                 960 


Leu Lys Glu Thr Leu Ser Ile Val Ala Val Glu Leu Glu Leu Lys Asp 
                965                 970                 975     


Phe Met Asn Val Leu Pro Glu Asp Gly Thr Ala Thr Phe Phe Leu Pro 
            980                 985                 990         


Tyr Leu Leu Tyr Cys Ser Arg Lys  Lys Pro Leu Thr 
        995                 1000                 


<210>  359
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  359

Met Val Gln Leu Tyr Asn Leu His Pro Phe Gly Ser Gln Gln Val Val 
1               5                   10                  15      


Pro Cys Lys Leu Glu Pro Asp Arg Phe Cys Gly Gly Gly Arg Asp Ala 
            20                  25                  30          


Leu Phe Val Ala Ala Gly Cys Lys Val Glu Ala Phe Ala Val Ala Gly 
        35                  40                  45              


Gln Glu Leu Cys Gln Pro Arg Cys Ala Phe Ser Thr Leu Gly Arg Val 
    50                  55                  60                  


Leu Arg Leu Ala Tyr Ser Glu Ala Gly Ile Ser Asn Glu Ile Ser Gln 
65                  70                  75                  80  


Leu Glu Ser Asp Asp Phe Val Ile Cys Gln Lys Pro Leu Glu Leu Leu 
                85                  90                  95      


Gly Glu Lys Ser Glu Gln Ser Gly Leu Ser Val Thr Leu Glu Ser Thr 
            100                 105                 110         


Gly Leu Ala Asp Glu Lys Arg Lys Tyr Ser His Phe Gln His Leu Leu 
        115                 120                 125             


Tyr Arg Arg Phe Ala Pro Asp Ile Ser Ser Tyr Val Leu Ser Asp Asp 
    130                 135                 140                 


Ile Lys Leu His Ser Leu Gln Leu Leu Pro Ile Tyr Gln Thr Gly Ser 
145                 150                 155                 160 


Leu Thr Ser Asp Gly Lys Asn Leu Ser Gln Glu Lys Glu Leu Leu Ser 
                165                 170                 175     


Leu Phe Cys Phe Phe Ser Leu Pro His Val Gly Tyr Leu Tyr Met Val 
            180                 185                 190         


Val Lys Ser Val Glu Leu Met Ser Val Tyr Gln Tyr Pro Glu Lys Ser 
        195                 200                 205             


Gln Gln Ala Val Leu Thr Pro Gln Phe Leu His Val Ile Thr Ser Asn 
    210                 215                 220                 


Asn Leu Gln Cys Phe Thr Val Arg Cys Ser Ala Ala Ala Ala Arg Glu 
225                 230                 235                 240 


Glu Asp Pro Tyr Met Asp Thr Thr Leu Lys Ala Cys Pro Pro Val Ser 
                245                 250                 255     


Met Asp Val Cys Ala Leu Arg Ile Gln Leu Phe Ile Gly Leu Lys Ala 
            260                 265                 270         


Ile Cys His Phe Lys Asn His Ile Ile Leu Leu Thr Lys Ala Glu Pro 
        275                 280                 285             


Glu Ala Ile Pro Glu Arg Arg Gln Ser Pro Lys Arg Leu Leu Ser Arg 
    290                 295                 300                 


Lys Asp Thr Ser Val Lys Ile Lys Ile Pro Pro Val Ala Glu Ala Gly 
305                 310                 315                 320 


Trp Asn Leu Tyr Ile Val Asn Thr Ile Ser Pro Val Gln Leu Tyr Lys 
                325                 330                 335     


Glu Met Val Asp Tyr Ser Asn Thr Tyr Lys Thr Val Lys Thr Gln Ser 
            340                 345                 350         


Cys Ile His Leu Leu Ser Glu Ala His Leu Leu Val Arg Ala Ala Leu 
        355                 360                 365             


Met Asp Ala Ser Gln Leu Glu Pro Gly Glu Lys Ala Glu Leu Leu Glu 
    370                 375                 380                 


Ala Phe Lys Glu Ser Cys Gly His Leu Gly Asp Cys Tyr Ser Arg Leu 
385                 390                 395                 400 


Asp Ser Gln His Ser His Leu Thr Leu Pro Tyr Tyr Lys Met Ser Gly 
                405                 410                 415     


Leu Ser Met Ala Glu Val Leu Ala Arg Thr Asp Trp Thr Val Glu Asp 
            420                 425                 430         


Gly Leu Gln Lys Tyr Glu Arg Gly Leu Ile Phe Tyr Ile Asn His Ser 
        435                 440                 445             


Leu Tyr Glu Asn Leu Asp Glu Glu Leu Asn Glu Glu Leu Ala Ala Lys 
    450                 455                 460                 


Val Val Gln Met Phe Tyr Val Ala Glu Pro Lys Gln Val Pro His Ile 
465                 470                 475                 480 


Leu Cys Ser Pro Ser Met Lys Asn Ile Asn Pro Leu Thr Ala Met Ser 
                485                 490                 495     


Tyr Leu Arg Lys Leu Asp Thr Ser Gly Phe Ser Ser Ile Leu Val Thr 
            500                 505                 510         


Leu Thr Lys Ala Ala Val Ala Leu Lys Met Gly Asp Leu Asp Met His 
        515                 520                 525             


Arg Asn Glu Met Lys Ser His Ser Glu Met Lys Leu Val Cys Gly Phe 
    530                 535                 540                 


Ile Leu Glu Pro Arg Leu Leu Ile Gln Gln Arg Lys Gly Gln Ile Val 
545                 550                 555                 560 


Pro Thr Glu Leu Ala Leu His Leu Lys Glu Thr Gln Pro Gly Leu Leu 
                565                 570                 575     


Val Ala Ser Val Leu Gly Leu Gln Lys Asn Asn Lys Ile Gly Ile Glu 
            580                 585                 590         


Glu Ala Asp Ser Phe Phe Lys Val Leu Cys Ala Lys Asp Glu Asp Thr 
        595                 600                 605             


Ile Pro Gln Leu Leu Val Asp Phe Trp Glu Ala Gln Leu Val Ala Cys 
    610                 615                 620                 


Leu Pro Asp Val Val Leu Gln Glu Leu Phe Phe Lys Leu Thr Ser Gln 
625                 630                 635                 640 


Tyr Ile Trp Arg Leu Ser Lys Arg Gln Pro Pro Asp Thr Thr Pro Leu 
                645                 650                 655     


Arg Thr Ser Glu Asp Leu Ile Asn Ala Cys Ser His Tyr Gly Leu Ile 
            660                 665                 670         


Tyr Pro Trp Val His Val Val Ile Ser Ser Asp Ser Leu Ala Asp Lys 
        675                 680                 685             


Asn Tyr Thr Glu Asp Leu Ser Lys Leu Gln Ser Leu Ile Cys Gly Pro 
    690                 695                 700                 


Ser Phe Asp Ile Ala Ser Ile Ile Pro Phe Leu Glu Pro Leu Ser Glu 
705                 710                 715                 720 


Asp Thr Ile Ala Gly Leu Ser Val His Val Leu Cys Arg Thr Arg Leu 
                725                 730                 735     


Lys Glu Tyr Glu Gln Cys Ile Asp Ile Leu Leu Glu Arg Cys Pro Glu 
            740                 745                 750         


Ala Val Ile Pro Tyr Ala Asn His Glu Leu Lys Glu Glu Asn Arg Thr 
        755                 760                 765             


Leu Trp Trp Lys Lys Leu Leu Pro Glu Leu Cys Gln Arg Ile Lys Cys 
    770                 775                 780                 


Gly Gly Glu Lys Tyr Gln Leu Tyr Leu Ser Ser Leu Lys Glu Thr Leu 
785                 790                 795                 800 


Ser Ile Val Ala Val Glu Leu Glu Leu Lys Asp Phe Met Asn Val Leu 
                805                 810                 815     


Pro Glu Asp Gly Thr Ala Thr Phe Phe Leu Pro Tyr Leu Leu Tyr Cys 
            820                 825                 830         


Ser Arg Lys Lys Pro Leu Thr 
        835                 


<210>  360
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  360

Glu Leu Ala Ala Lys Val Val Gln Met Phe Tyr Val Ala Glu Pro Lys 
1               5                   10                  15      


Gln Val Pro His Ile Leu Cys Ser Pro Ser Met Lys Asn Ile Asn Pro 
            20                  25                  30          


Leu Thr Ala Met Ser Tyr Leu Arg Lys Leu Asp Thr Ser Gly Phe Ser 
        35                  40                  45              


Ser Ile Leu Val Thr Leu Thr Lys Ala Ala Val Ala Leu Lys Met Gly 
    50                  55                  60                  


Asp Leu Asp Met His Arg Asn Glu Met Lys Ser His Ser Glu Met Lys 
65                  70                  75                  80  


Leu Val Cys Gly Phe Ile Leu Glu Pro Arg Leu Leu Ile Gln Gln Arg 
                85                  90                  95      


Lys Gly Gln Ile Val Pro Thr Glu Leu Ala Leu His Leu Lys Glu Thr 
            100                 105                 110         


Gln Pro Gly Leu Leu Val Ala Ser Val Leu Gly Leu Gln Lys Asn Asn 
        115                 120                 125             


Lys Ile Gly Ile Glu Glu Ala Asp Ser Phe Phe Lys Val Leu Cys Ala 
    130                 135                 140                 


Lys Asp Glu Asp Thr Ile Pro Gln Leu Leu Val Asp Phe Trp Glu Ala 
145                 150                 155                 160 


Gln Leu Val Ala Cys Leu Pro Asp Val Val Leu Gln Glu Leu Phe Phe 
                165                 170                 175     


Lys Leu Thr Ser Gln Tyr Ile Trp Arg Leu Ser Lys Arg Gln Pro Pro 
            180                 185                 190         


Asp Thr Thr Pro Leu Arg Thr Ser Glu Asp Leu Ile Asn Ala Cys Ser 
        195                 200                 205             


His Tyr Gly Leu Ile Tyr Pro Trp Val His Val Val Ile Ser Ser Asp 
    210                 215                 220                 


Ser Leu Ala Asp Lys Asn Tyr Thr Glu Asp Leu Ser Lys Leu Gln Leu 
225                 230                 235                 240 


Pro Leu Phe Arg Ser Trp Ser His Phe Gln Lys Thr Leu Leu Pro Ala 
                245                 250                 255     


Ser Val Ser Met Phe Cys Val Val His Ala 
            260                 265     


<210>  361
<211>  1237
<212>  PRT
<213>  Homo sapiens

<400>  361

Met Gly Asp Met Lys Thr Pro Asp Phe Asp Asp Leu Leu Ala Ala Phe 
1               5                   10                  15      


Asp Ile Pro Asp Ile Asp Ala Asn Glu Ala Ile His Ser Gly Pro Glu 
            20                  25                  30          


Glu Asn Glu Gly Pro Gly Gly Pro Gly Lys Pro Glu Pro Gly Val Gly 
        35                  40                  45              


Ser Glu Ser Glu Asp Thr Ala Ala Ala Ser Ala Gly Asp Gly Pro Gly 
    50                  55                  60                  


Val Pro Ala Gln Ala Ser Asp His Gly Leu Pro Pro Pro Asp Ile Ser 
65                  70                  75                  80  


Val Val Ser Val Ile Val Lys Asn Thr Val Cys Pro Glu Gln Ser Glu 
                85                  90                  95      


Ala Leu Ala Gly Gly Ser Ala Gly Asp Gly Ala Gln Ala Ala Gly Val 
            100                 105                 110         


Thr Lys Glu Gly Pro Val Gly Pro His Arg Met Gln Asn Gly Phe Gly 
        115                 120                 125             


Ser Pro Glu Pro Ser Leu Pro Gly Thr Pro His Ser Pro Ala Pro Pro 
    130                 135                 140                 


Ser Gly Gly Thr Trp Lys Glu Lys Gly Met Glu Gly Lys Thr Pro Leu 
145                 150                 155                 160 


Asp Leu Phe Ala His Phe Gly Pro Glu Pro Gly Asp His Ser Asp Pro 
                165                 170                 175     


Leu Pro Pro Ser Ala Pro Ser Pro Thr Arg Glu Gly Ala Leu Thr Pro 
            180                 185                 190         


Pro Pro Phe Pro Ser Ser Phe Glu Leu Ala Gln Glu Asn Gly Pro Gly 
        195                 200                 205             


Met Gln Pro Pro Val Ser Ser Pro Pro Leu Gly Ala Leu Lys Gln Glu 
    210                 215                 220                 


Ser Cys Ser Pro His His Pro Gln Val Leu Ala Gln Gln Gly Ser Gly 
225                 230                 235                 240 


Ser Ser Pro Lys Ala Thr Asp Ile Pro Ala Ser Ala Ser Pro Pro Pro 
                245                 250                 255     


Val Ala Gly Val Pro Phe Phe Lys Gln Ser Pro Gly His Gln Ser Pro 
            260                 265                 270         


Leu Ala Ser Pro Lys Val Pro Val Cys Gln Pro Leu Lys Glu Glu Asp 
        275                 280                 285             


Asp Asp Glu Gly Pro Val Asp Lys Ser Ser Pro Gly Ser Pro Gln Ser 
    290                 295                 300                 


Pro Ser Ser Gly Ala Glu Ala Ala Asp Glu Asp Ser Asn Asp Ser Pro 
305                 310                 315                 320 


Ala Ser Ser Ser Ser Arg Pro Leu Lys Val Arg Ile Lys Thr Ile Lys 
                325                 330                 335     


Thr Ser Cys Gly Asn Ile Thr Arg Thr Val Thr Gln Val Pro Ser Asp 
            340                 345                 350         


Pro Asp Pro Pro Ala Pro Leu Ala Glu Gly Ala Phe Leu Ala Glu Ala 
        355                 360                 365             


Ser Leu Leu Lys Leu Ser Pro Ala Thr Pro Thr Ser Glu Gly Pro Lys 
    370                 375                 380                 


Val Val Ser Val Gln Leu Gly Asp Gly Thr Arg Leu Lys Gly Thr Val 
385                 390                 395                 400 


Leu Pro Val Ala Thr Ile Gln Asn Ala Ser Thr Ala Met Leu Met Ala 
                405                 410                 415     


Ala Ser Val Ala Arg Lys Ala Val Val Leu Pro Gly Gly Thr Ala Thr 
            420                 425                 430         


Ser Pro Lys Met Ile Ala Lys Asn Val Leu Gly Leu Val Pro Gln Ala 
        435                 440                 445             


Leu Pro Lys Ala Asp Gly Arg Ala Gly Leu Gly Thr Gly Gly Gln Lys 
    450                 455                 460                 


Val Asn Gly Ala Ser Val Val Met Val Gln Pro Ser Lys Thr Ala Thr 
465                 470                 475                 480 


Gly Pro Ser Thr Gly Gly Gly Thr Val Ile Ser Arg Thr Gln Ser Ser 
                485                 490                 495     


Leu Val Glu Ala Phe Asn Lys Ile Leu Asn Ser Lys Asn Leu Leu Pro 
            500                 505                 510         


Ala Tyr Arg Pro Asn Leu Ser Pro Pro Ala Glu Ala Gly Leu Ala Leu 
        515                 520                 525             


Pro Pro Thr Gly Tyr Arg Cys Leu Glu Cys Gly Asp Ala Phe Ser Leu 
    530                 535                 540                 


Glu Lys Ser Leu Ala Arg His Tyr Asp Arg Arg Ser Met Arg Ile Glu 
545                 550                 555                 560 


Val Thr Cys Asn His Cys Ala Arg Arg Leu Val Phe Phe Asn Lys Cys 
                565                 570                 575     


Ser Leu Leu Leu His Ala Arg Glu His Lys Asp Lys Gly Leu Val Met 
            580                 585                 590         


Gln Cys Ser His Leu Val Met Arg Pro Val Ala Leu Asp Gln Met Val 
        595                 600                 605             


Gly Gln Pro Asp Ile Thr Pro Leu Leu Pro Val Ala Val Pro Pro Val 
    610                 615                 620                 


Ser Gly Pro Leu Ala Leu Pro Ala Leu Gly Lys Gly Glu Gly Ala Ile 
625                 630                 635                 640 


Thr Ser Ser Ala Ile Thr Thr Val Ala Ala Glu Ala Pro Val Leu Pro 
                645                 650                 655     


Leu Ser Thr Glu Pro Pro Ala Ala Pro Ala Thr Ser Ala Tyr Thr Cys 
            660                 665                 670         


Phe Arg Cys Leu Glu Cys Lys Glu Gln Cys Arg Asp Lys Ala Gly Met 
        675                 680                 685             


Ala Ala His Phe Gln Gln Leu Gly Pro Pro Ala Pro Gly Ala Thr Ser 
    690                 695                 700                 


Asn Val Cys Pro Thr Cys Pro Met Met Leu Pro Asn Arg Cys Ser Phe 
705                 710                 715                 720 


Ser Ala His Gln Arg Met His Lys Asn Arg Pro Pro His Val Cys Pro 
                725                 730                 735     


Glu Cys Gly Gly Asn Phe Leu Gln Ala Asn Phe Gln Thr His Leu Arg 
            740                 745                 750         


Glu Ala Cys Leu His Val Ser Arg Arg Val Gly Tyr Arg Cys Pro Ser 
        755                 760                 765             


Cys Ser Val Val Phe Gly Gly Val Asn Ser Ile Lys Ser His Ile Gln 
    770                 775                 780                 


Thr Ser His Cys Glu Val Phe His Lys Cys Pro Ile Cys Pro Met Ala 
785                 790                 795                 800 


Phe Lys Ser Gly Pro Ser Ala His Ala His Leu Tyr Ser Gln His Pro 
                805                 810                 815     


Ser Phe Gln Thr Gln Gln Ala Lys Leu Ile Tyr Lys Cys Ala Met Cys 
            820                 825                 830         


Asp Thr Val Phe Thr His Lys Pro Leu Leu Ser Ser His Phe Asp Gln 
        835                 840                 845             


His Leu Leu Pro Gln Arg Val Ser Val Phe Lys Cys Pro Ser Cys Pro 
    850                 855                 860                 


Leu Leu Phe Ala Gln Lys Arg Thr Met Leu Glu His Leu Lys Asn Thr 
865                 870                 875                 880 


His Gln Ser Gly Arg Leu Glu Glu Thr Ala Gly Lys Gly Ala Gly Gly 
                885                 890                 895     


Ala Leu Leu Thr Pro Lys Thr Glu Pro Glu Glu Leu Ala Val Ser Gln 
            900                 905                 910         


Gly Gly Ala Ala Pro Ala Thr Glu Glu Ser Ser Ser Ser Ser Glu Glu 
        915                 920                 925             


Glu Glu Val Pro Ser Ser Pro Glu Pro Pro Arg Pro Ala Lys Arg Pro 
    930                 935                 940                 


Arg Arg Glu Leu Gly Ser Lys Gly Leu Lys Gly Gly Gly Gly Gly Pro 
945                 950                 955                 960 


Gly Gly Trp Thr Cys Gly Leu Cys His Ser Trp Phe Pro Glu Arg Asp 
                965                 970                 975     


Glu Tyr Val Ala His Met Lys Lys Glu His Gly Lys Ser Val Lys Lys 
            980                 985                 990         


Phe Pro Cys Arg Leu Cys Glu Arg  Ser Phe Cys Ser Ala  Pro Ser Leu 
        995                 1000                 1005             


Arg Arg  His Val Arg Val Asn  His Glu Gly Ile Lys  Arg Val Tyr 
    1010                 1015                 1020             


Pro Cys  Arg Tyr Cys Thr Glu  Gly Lys Arg Thr Phe  Ser Ser Arg 
    1025                 1030                 1035             


Leu Ile  Leu Glu Lys His Val  Gln Val Arg His Gly  Leu Gln Leu 
    1040                 1045                 1050             


Gly Ala  Gln Ser Pro Gly Arg  Gly Thr Thr Leu Ala  Arg Gly Ser 
    1055                 1060                 1065             


Ser Ala  Arg Ala Gln Gly Pro  Gly Arg Lys Arg Arg  Gln Ser Ser 
    1070                 1075                 1080             


Asp Ser  Cys Ser Glu Glu Pro  Asp Ser Thr Thr Pro  Pro Ala Lys 
    1085                 1090                 1095             


Ser Pro  Arg Gly Gly Pro Gly  Ser Gly Gly His Gly  Pro Leu Arg 
    1100                 1105                 1110             


Tyr Arg  Ser Ser Ser Ser Thr  Glu Gln Ser Leu Met  Met Gly Leu 
    1115                 1120                 1125             


Arg Val  Glu Asp Gly Ala Gln  Gln Cys Leu Asp Cys  Gly Leu Cys 
    1130                 1135                 1140             


Phe Ala  Ser Pro Gly Ser Leu  Ser Arg His Arg Phe  Ile Ser His 
    1145                 1150                 1155             


Lys Lys  Arg Arg Gly Val Gly  Lys Ala Ser Ala Leu  Gly Leu Gly 
    1160                 1165                 1170             


Asp Gly  Glu Glu Glu Ala Pro  Pro Ser Arg Ser Asp  Pro Asp Gly 
    1175                 1180                 1185             


Gly Asp  Ser Pro Leu Pro Ala  Ser Gly Gly Pro Leu  Thr Cys Lys 
    1190                 1195                 1200             


Val Cys  Gly Lys Ser Cys Asp  Ser Pro Leu Asn Leu  Lys Thr His 
    1205                 1210                 1215             


Phe Arg  Thr His Gly Met Ala  Phe Ile Arg Ala Arg  Gln Gly Ala 
    1220                 1225                 1230             


Val Gly  Asp Asn 
    1235         


<210>  362
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  362

Arg Thr Phe Ser Ser Arg Leu Ile Leu Glu Lys His Val Gln Val Arg 
1               5                   10                  15      


His Gly Leu Gln Leu Gly Ala Gln Ser Pro Gly Arg Gly Thr Thr Leu 
            20                  25                  30          


Ala Arg Gly Ser Ser Ala Arg Ala Gln Phe Leu Pro Leu Phe Phe Arg 
        35                  40                  45              


Gly Gln Val Gly Asn Ala Ala Ser Leu Leu Thr Leu Ala Val Arg Ser 
    50                  55                  60                  


Leu Thr Ala Arg His Arg Gln Pro Ser Pro Pro Gly Ala Asp Leu Asp 
65                  70                  75                  80  


Leu Glu Ala Met Ala Leu Cys Ala Thr Gly Ala Ala Ala Pro Gln Asn 
                85                  90                  95      


Arg Ala Ser 
            


<210>  363
<211>  706
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  363

Xaa Thr Val Leu Pro Val Ala Thr Ile Gln Asn Ala Ser Thr Ala Met 
1               5                   10                  15      


Leu Met Ala Ala Ser Val Ala Arg Lys Ala Val Val Leu Pro Gly Gly 
            20                  25                  30          


Thr Ala Thr Ser Pro Lys Met Ile Ala Lys Asn Val Leu Gly Leu Val 
        35                  40                  45              


Pro Gln Ala Leu Pro Lys Ala Asp Gly Arg Ala Gly Leu Gly Thr Gly 
    50                  55                  60                  


Gly Gln Lys Val Asn Gly Ala Ser Val Val Met Val Gln Pro Ser Lys 
65                  70                  75                  80  


Thr Ala Thr Gly Pro Ser Thr Gly Gly Gly Thr Val Ile Ser Arg Thr 
                85                  90                  95      


Gln Ser Ser Leu Val Glu Ala Phe Asn Lys Ile Leu Asn Ser Lys Asn 
            100                 105                 110         


Leu Leu Pro Ala Tyr Arg Pro Asn Leu Ser Pro Pro Ala Glu Ala Gly 
        115                 120                 125             


Leu Ala Leu Pro Pro Thr Gly Tyr Arg Cys Leu Glu Cys Gly Asp Ala 
    130                 135                 140                 


Phe Ser Leu Glu Lys Ser Leu Ala Arg His Tyr Asp Arg Arg Ser Met 
145                 150                 155                 160 


Arg Ile Glu Val Thr Cys Asn His Cys Ala Arg Arg Leu Val Phe Phe 
                165                 170                 175     


Asn Lys Cys Ser Leu Leu Leu His Ala Arg Glu His Lys Asp Lys Gly 
            180                 185                 190         


Leu Val Met Gln Cys Ser His Leu Val Met Arg Pro Val Ala Leu Asp 
        195                 200                 205             


Gln Met Val Gly Gln Pro Asp Ile Thr Pro Leu Leu Pro Val Ala Val 
    210                 215                 220                 


Pro Pro Val Ser Gly Pro Leu Ala Leu Pro Ala Leu Gly Lys Gly Glu 
225                 230                 235                 240 


Gly Ala Ile Thr Ser Ser Ala Ile Thr Thr Val Ala Ala Glu Ala Pro 
                245                 250                 255     


Val Leu Pro Leu Ser Thr Glu Pro Pro Ala Ala Pro Ala Thr Ser Ala 
            260                 265                 270         


Tyr Thr Cys Phe Arg Cys Leu Glu Cys Lys Glu Gln Cys Arg Asp Lys 
        275                 280                 285             


Ala Gly Met Ala Ala His Phe Gln Gln Leu Gly Pro Pro Ala Pro Gly 
    290                 295                 300                 


Ala Thr Ser Asn Val Cys Pro Thr Cys Pro Met Met Leu Pro Asn Arg 
305                 310                 315                 320 


Cys Ser Phe Ser Ala His Gln Arg Met His Lys Asn Arg Pro Pro His 
                325                 330                 335     


Val Cys Pro Glu Cys Gly Gly Asn Phe Leu Gln Ala Asn Phe Gln Thr 
            340                 345                 350         


His Leu Arg Glu Ala Cys Leu His Val Ser Arg Arg Val Gly Tyr Arg 
        355                 360                 365             


Cys Pro Ser Cys Ser Val Val Phe Gly Gly Val Asn Ser Ile Lys Ser 
    370                 375                 380                 


His Ile Gln Thr Ser His Cys Glu Val Phe His Lys Cys Pro Ile Cys 
385                 390                 395                 400 


Pro Met Ala Phe Lys Ser Gly Pro Ser Ala His Ala His Leu Tyr Ser 
                405                 410                 415     


Gln His Pro Ser Phe Gln Thr Gln Gln Ala Lys Leu Ile Tyr Lys Cys 
            420                 425                 430         


Ala Met Cys Asp Thr Val Phe Thr His Lys Pro Leu Leu Ser Ser His 
        435                 440                 445             


Phe Asp Gln His Leu Leu Pro Gln Arg Val Ser Val Phe Lys Cys Pro 
    450                 455                 460                 


Ser Cys Pro Leu Leu Phe Ala Gln Lys Arg Thr Met Leu Glu His Leu 
465                 470                 475                 480 


Lys Asn Thr His Gln Ser Gly Arg Leu Glu Glu Thr Ala Gly Lys Gly 
                485                 490                 495     


Ala Gly Gly Ala Leu Leu Thr Pro Lys Thr Glu Pro Glu Glu Leu Ala 
            500                 505                 510         


Val Ser Gln Gly Gly Ala Ala Pro Ala Thr Glu Glu Ser Ser Ser Ser 
        515                 520                 525             


Ser Glu Glu Glu Glu Val Pro Ser Ser Pro Glu Pro Pro Arg Pro Ala 
    530                 535                 540                 


Lys Arg Pro Arg Arg Glu Leu Gly Ser Lys Gly Leu Lys Gly Gly Gly 
545                 550                 555                 560 


Gly Gly Pro Gly Gly Trp Thr Cys Gly Leu Cys His Ser Trp Phe Pro 
                565                 570                 575     


Glu Arg Asp Glu Tyr Val Ala His Met Lys Lys Glu His Gly Lys Ser 
            580                 585                 590         


Val Lys Lys Phe Pro Cys Arg Leu Cys Glu Arg Ser Phe Cys Ser Ala 
        595                 600                 605             


Pro Ser Leu Arg Arg His Val Arg Val Asn His Glu Gly Ile Lys Arg 
    610                 615                 620                 


Val Tyr Pro Cys Arg Ser Lys Gly Pro Gly Leu Arg Ala Val Pro Leu 
625                 630                 635                 640 


Leu Pro Ser Cys Pro Leu Pro Phe Gln Val Leu His Arg Gly Lys Thr 
                645                 650                 655     


His Leu Gln Gln Pro Pro Asp Pro Arg Glu Thr Cys Pro Gly Pro Ala 
            660                 665                 670         


Arg Leu Ala Ala Trp Gly Pro Val Pro Trp Pro Gly Asp His Leu Gly 
        675                 680                 685             


Ser Gly Phe Gln Cys Gln Ser Pro Gly Ala Arg Ser Glu Thr Pro Pro 
    690                 695                 700                 


Val Phe 
705     


<210>  364
<211>  785
<212>  PRT
<213>  Homo sapiens

<400>  364

Met Gly Asp Met Lys Thr Pro Asp Phe Asp Asp Leu Leu Ala Ala Phe 
1               5                   10                  15      


Asp Ile Pro Asp Ile Asp Ala Asn Glu Ala Ile His Ser Gly Pro Glu 
            20                  25                  30          


Glu Asn Glu Gly Pro Gly Gly Pro Gly Lys Pro Glu Pro Gly Val Gly 
        35                  40                  45              


Ser Glu Ser Glu Asp Thr Ala Ala Ala Ser Ala Gly Asp Gly Pro Gly 
    50                  55                  60                  


Val Pro Ala Gln Ala Ser Asp His Gly Leu Pro Pro Pro Asp Ile Ser 
65                  70                  75                  80  


Val Val Ser Val Ile Val Lys Asn Thr Val Cys Pro Glu Gln Ser Glu 
                85                  90                  95      


Ala Leu Ala Gly Gly Ser Ala Gly Asp Gly Ala Gln Ala Ala Gly Val 
            100                 105                 110         


Thr Lys Glu Gly Pro Val Gly Pro His Arg Met Gln Asn Gly Phe Gly 
        115                 120                 125             


Ser Pro Glu Pro Ser Leu Pro Gly Thr Pro His Ser Pro Ala Pro Pro 
    130                 135                 140                 


Ser Gly Gly Thr Trp Lys Glu Lys Gly Met Glu Gly Lys Thr Pro Leu 
145                 150                 155                 160 


Asp Leu Phe Ala His Phe Gly Pro Glu Pro Gly Asp His Ser Asp Pro 
                165                 170                 175     


Leu Pro Pro Ser Ala Pro Ser Pro Thr Arg Glu Gly Ala Leu Thr Pro 
            180                 185                 190         


Pro Pro Phe Pro Ser Ser Phe Glu Leu Ala Gln Glu Asn Gly Pro Gly 
        195                 200                 205             


Met Gln Pro Pro Val Ser Ser Pro Pro Leu Gly Ala Leu Lys Gln Glu 
    210                 215                 220                 


Ser Cys Ser Pro His His Pro Gln Val Leu Ala Gln Gln Gly Ser Gly 
225                 230                 235                 240 


Ser Ser Pro Lys Ala Thr Asp Ile Pro Ala Ser Ala Ser Pro Pro Pro 
                245                 250                 255     


Val Ala Gly Val Pro Phe Phe Lys Gln Ser Pro Gly His Gln Ser Pro 
            260                 265                 270         


Leu Ala Ser Pro Lys Val Pro Val Cys Gln Pro Leu Lys Glu Glu Asp 
        275                 280                 285             


Asp Asp Glu Gly Pro Val Asp Lys Ser Ser Pro Gly Ser Pro Gln Ser 
    290                 295                 300                 


Pro Ser Ser Gly Ala Glu Ala Ala Asp Glu Asp Ser Asn Asp Ser Pro 
305                 310                 315                 320 


Ala Ser Ser Ser Ser Arg Pro Leu Lys Val Arg Ile Lys Thr Ile Lys 
                325                 330                 335     


Thr Ser Cys Gly Asn Ile Thr Arg Thr Val Thr Gln Val Pro Ser Asp 
            340                 345                 350         


Pro Asp Pro Pro Ala Pro Leu Ala Glu Gly Ala Phe Leu Ala Glu Ala 
        355                 360                 365             


Ser Leu Leu Lys Leu Ser Pro Ala Thr Pro Thr Ser Glu Gly Pro Lys 
    370                 375                 380                 


Val Val Ser Val Gln Leu Gly Asp Gly Thr Arg Leu Lys Gly Thr Val 
385                 390                 395                 400 


Leu Pro Val Ala Thr Ile Gln Asn Ala Ser Thr Ala Met Leu Met Ala 
                405                 410                 415     


Ala Ser Val Ala Arg Lys Ala Val Val Leu Pro Gly Gly Thr Ala Thr 
            420                 425                 430         


Ser Pro Lys Met Ile Ala Lys Asn Val Leu Gly Leu Val Pro Gln Ala 
        435                 440                 445             


Leu Pro Lys Ala Asp Gly Arg Ala Gly Leu Gly Thr Gly Gly Gln Lys 
    450                 455                 460                 


Val Asn Gly Ala Ser Val Val Met Val Gln Pro Ser Lys Thr Ala Thr 
465                 470                 475                 480 


Gly Pro Ser Thr Gly Gly Gly Thr Val Ile Ser Arg Thr Gln Ser Ser 
                485                 490                 495     


Leu Val Glu Ala Phe Asn Lys Ile Leu Asn Ser Lys Asn Leu Leu Pro 
            500                 505                 510         


Ala Tyr Arg Pro Asn Leu Ser Pro Pro Ala Glu Ala Gly Leu Ala Leu 
        515                 520                 525             


Pro Pro Thr Gly Tyr Arg Cys Leu Glu Cys Gly Asp Ala Phe Ser Leu 
    530                 535                 540                 


Glu Lys Ser Leu Ala Arg His Tyr Asp Arg Arg Ser Met Arg Ile Glu 
545                 550                 555                 560 


Val Thr Cys Asn His Cys Ala Arg Arg Leu Val Phe Phe Asn Lys Cys 
                565                 570                 575     


Ser Leu Leu Leu His Ala Arg Glu His Lys Asp Lys Gly Leu Val Met 
            580                 585                 590         


Gln Cys Ser His Leu Val Met Arg Pro Val Ala Leu Asp Gln Met Val 
        595                 600                 605             


Gly Gln Pro Asp Ile Thr Pro Leu Leu Pro Val Ala Val Pro Pro Val 
    610                 615                 620                 


Ser Gly Pro Leu Ala Leu Pro Ala Leu Gly Lys Gly Glu Gly Ala Ile 
625                 630                 635                 640 


Thr Ser Ser Ala Ile Thr Thr Val Ala Ala Glu Ala Pro Val Leu Pro 
                645                 650                 655     


Leu Ser Thr Glu Pro Pro Ala Ala Pro Ala Thr Ser Ala Tyr Thr Cys 
            660                 665                 670         


Phe Arg Cys Leu Glu Cys Lys Glu Gln Cys Arg Asp Lys Ala Gly Met 
        675                 680                 685             


Ala Ala His Phe Gln Gln Leu Gly Pro Pro Ala Pro Gly Ala Thr Ser 
    690                 695                 700                 


Asn Val Cys Pro Thr Cys Pro Met Met Leu Pro Asn Arg Cys Ser Phe 
705                 710                 715                 720 


Ser Ala His Gln Arg Met His Lys Asn Arg Pro Pro His Val Cys Pro 
                725                 730                 735     


Glu Cys Gly Gly Asn Phe Leu Gln Ala Asn Phe Gln Thr His Leu Arg 
            740                 745                 750         


Glu Ala Cys Leu His Val Ser Arg Arg Val Gly Tyr Arg Thr Pro Ile 
        755                 760                 765             


Ser Leu Gly Ala Trp Arg Arg Leu Leu Gly Lys Gly Pro Gly Val Pro 
    770                 775                 780                 


Cys 
785 


<210>  365
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  365

Met Gly Arg Gly Leu Gly Ser Ala Asp Met Gly Asp Met Lys Thr Pro 
1               5                   10                  15      


Asp Phe Asp Asp Leu Leu Ala Ala Phe Asp Ile Pro Asp Ile Asp Ala 
            20                  25                  30          


Asn Glu Ala Ile His Ser Gly Pro Glu Glu Asn Glu Gly Pro Gly Gly 
        35                  40                  45              


Pro Gly Lys Pro Glu Pro Gly Val Gly Ser Glu Ser Glu Asp Thr Ala 
    50                  55                  60                  


Ala Ala Ser Ala Gly Asp Gly Pro Gly Val Pro Ala Gln Ala Ser Asp 
65                  70                  75                  80  


His Gly Leu Pro Pro Pro Asp Ile Ser Val Val Ser Val Ile Val Lys 
                85                  90                  95      


Asn Thr Val Cys Pro Glu Gln Ser Glu Ala Leu Ala Gly Gly Ser Ala 
            100                 105                 110         


Gly Asp Gly Ala Gln Ala Ala Gly Val Thr Lys Glu Gly Pro Val Gly 
        115                 120                 125             


Pro His Arg Met Gln Asn Gly Phe Gly Ser Pro Glu Pro Ser Leu Pro 
    130                 135                 140                 


Gly Thr Pro 
145         


<210>  366
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  366

Met Asn Leu Ala Ile Ser Ile Ala Leu Leu Leu Thr Val Leu Gln Val 
1               5                   10                  15      


Ser Arg Gly Gln Lys Val Thr Ser Leu Thr Ala Cys Leu Val Asp Gln 
            20                  25                  30          


Ser Leu Arg Leu Asp Cys Arg His Glu Asn Thr Ser Ser Ser Pro Ile 
        35                  40                  45              


Gln Tyr Glu Phe Ser Leu Thr Arg Glu Thr Lys Lys His Val Leu Phe 
    50                  55                  60                  


Gly Thr Val Gly Val Pro Glu His Thr Tyr Arg Ser Arg Thr Asn Phe 
65                  70                  75                  80  


Thr Ser Lys Tyr Asn Met Lys Val Leu Tyr Leu Ser Ala Phe Thr Ser 
                85                  90                  95      


Lys Asp Glu Gly Thr Tyr Thr Cys Ala Leu His His Ser Gly His Ser 
            100                 105                 110         


Pro Pro Ile Ser Ser Gln Asn Val Thr Val Leu Arg Asp Lys Leu Val 
        115                 120                 125             


Lys Cys Glu Gly Ile Ser Leu Leu Ala Gln Asn Thr Ser Trp Leu Leu 
    130                 135                 140                 


Leu Leu Leu Leu Ser Leu Ser Leu Leu Gln Ala Thr Asp Phe Met Ser 
145                 150                 155                 160 


Leu 
    


<210>  367
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  367

Met Asn Leu Ala Ile Ser Ile Ala Leu Leu Leu Thr Val Asp Gln Ser 
1               5                   10                  15      


Leu Arg Leu Asp Cys Arg His Glu Asn Thr Ser Ser Ser Pro Ile Gln 
            20                  25                  30          


Tyr Glu Phe Ser Leu Thr Arg Glu Thr Lys Lys His Val Leu Phe Gly 
        35                  40                  45              


Thr Val Gly Val Pro Glu His Thr Tyr Arg Ser Arg Thr Asn Phe Thr 
    50                  55                  60                  


Ser Lys Tyr Asn Met Lys Val Leu Tyr Leu Ser Ala Phe Thr Ser Lys 
65                  70                  75                  80  


Asp Glu Gly Thr Tyr Thr Cys Ala Leu His His Ser Gly His Ser Pro 
                85                  90                  95      


Pro Ile Ser Ser Gln Asn Val Thr Val Leu Arg Asp Lys Leu Val Lys 
            100                 105                 110         


Cys Glu Gly Ile Ser Leu Leu Ala Gln Asn Thr Ser Trp Leu Leu Leu 
        115                 120                 125             


Leu Leu Leu Ser Leu Ser Leu Leu Gln Ala Thr Asp Phe Met Ser Leu 
    130                 135                 140                 


<210>  368
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  368

Met Asn Leu Ala Ile Ser Ile Ala Leu Leu Leu Thr Val Leu Gln Val 
1               5                   10                  15      


Ser Arg Gly Gln Lys Val Thr Ser Leu Thr Ala Cys Leu Val Asp Gln 
            20                  25                  30          


Ser Leu Arg Leu Asp Cys Arg His Glu Asn Thr Ser Ser Ser Pro Ile 
        35                  40                  45              


Gln Tyr Glu Phe Ser Leu Thr Arg Glu Thr Lys Lys His Val Leu Phe 
    50                  55                  60                  


Gly Thr Val Gly Val Pro Glu His Thr Tyr Arg Ser Arg Thr Asn Phe 
65                  70                  75                  80  


Thr Ser Lys Tyr Asn Met Lys Val Leu Tyr Leu Ser Ala Phe Thr Ser 
                85                  90                  95      


Lys Asp Glu Gly Thr Tyr Thr Cys Ala Leu His His Ser Gly His Ser 
            100                 105                 110         


Pro Pro Ile Ser Ser Gln Asn Val Thr Val Leu Arg Asp Lys Leu Val 
        115                 120                 125             


Lys Cys Glu Gly Ile Ser Leu Leu Ala Gln Asn Thr Ser Trp Leu Leu 
    130                 135                 140                 


Leu Leu Leu Leu Ser Leu Ser Leu Leu 
145                 150             


<210>  369
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  369

Met Asn Leu Ala Ile Ser Ile Ala Leu Leu Leu Thr Val Leu Gln Val 
1               5                   10                  15      


Ser Arg Gly Gln Lys Val Thr Ser Leu Thr Ala Cys Leu Val Asp Gln 
            20                  25                  30          


Ser Leu Arg Leu Asp Cys Arg His Glu Asn Thr Ser Ser Ser Pro Ile 
        35                  40                  45              


Gln Tyr Glu Phe Ser Leu Thr Arg Glu Thr Lys Lys His Val Leu Phe 
    50                  55                  60                  


Gly Thr Val Gly Val Pro Glu His Thr Tyr Arg Ser Arg Thr Asn Phe 
65                  70                  75                  80  


Thr Ser Lys Tyr Asn Met Lys Val Leu Tyr Leu Ser Ala Phe Thr Ser 
                85                  90                  95      


Lys Asp Glu Gly Thr Tyr Thr Cys Ala Leu His His Ser Gly His Ser 
            100                 105                 110         


Pro Pro Ile Ser Ser Gln Asn Val Thr Val Leu Arg Gly His Gly Phe 
        115                 120                 125             


His Val Pro Val Thr Gly Gly Ala His Gly Gly Asp Arg Lys Pro Gln 
    130                 135                 140                 


Val Pro Val Gln Arg Ser Tyr Phe Ser Glu Ser Ala Asp Pro Leu Pro 
145                 150                 155                 160 


Pro Ile Pro Gln Thr 
                165 


<210>  370
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  370

Met Asn Leu Ala Ile Ser Ile Ala Leu Leu Leu Thr Gly Leu Pro Arg 
1               5                   10                  15      


Ala Glu Gly Asp Gln Pro Asn Gly Leu Pro Ser Gly Pro Glu Pro Ser 
            20                  25                  30          


Ser Gly Leu Pro Pro 
        35          


<210>  371
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  371

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 
    210                 215                 220                 


Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 
            260                 265                 270         


Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 
        275                 280                 285             


Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 
    290                 295                 300                 


Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 
    450                 455                 460                 


Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu 
465                 470                 475                 480 


Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala 
                485                 490                 495     


Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 
            500                 505                 510         


Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly 
        515                 520                 525             


Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 
    530                 535                 540                 


Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser 
545                 550                 555                 560 


Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly 
                565                 570                 575     


Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys 
            580                 585                 590         


Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg 
        595                 600                 605             


Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly 
    610                 615                 620                 


Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser 
625                 630                 635                 640 


Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala 
                645                 650                 655     


Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp 
            660                 665                 670         


Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro 
        675                 680                 685             


Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr 
    690                 695                 700                 


Glu Leu Ile Ser Val Ser Glu Val His Pro Ser Arg Leu Gln Thr Thr 
705                 710                 715                 720 


Asp Asn Leu Leu Pro Met Ser Pro Glu Glu Phe Asp Glu Val Ser Arg 
                725                 730                 735     


Ile Val Gly Ser Val Glu Phe Asp Ser Met Met Asn Thr Val 
            740                 745                 750 


<210>  372
<211>  712
<212>  PRT
<213>  Homo sapiens

<400>  372

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 
    210                 215                 220                 


Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 
            260                 265                 270         


Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 
        275                 280                 285             


Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 
    290                 295                 300                 


Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 
    450                 455                 460                 


Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu 
465                 470                 475                 480 


Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala 
                485                 490                 495     


Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 
            500                 505                 510         


Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly 
        515                 520                 525             


Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 
    530                 535                 540                 


Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser 
545                 550                 555                 560 


Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly 
                565                 570                 575     


Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys 
            580                 585                 590         


Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg 
        595                 600                 605             


Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly 
    610                 615                 620                 


Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser 
625                 630                 635                 640 


Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala 
                645                 650                 655     


Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp 
            660                 665                 670         


Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro 
        675                 680                 685             


Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr 
    690                 695                 700                 


Glu Leu Ile Ser Val Ser Glu Val 
705                 710         


<210>  373
<211>  714
<212>  PRT
<213>  Homo sapiens

<400>  373

Met Trp Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe 
1               5                   10                  15      


Leu Glu Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile 
            20                  25                  30          


Arg Gln Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala 
        35                  40                  45              


Ala Asn Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser 
    50                  55                  60                  


Gln Leu Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu 
65                  70                  75                  80  


Leu Gln His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe 
                85                  90                  95      


Gln Glu Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys 
            100                 105                 110         


Glu Glu Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln 
        115                 120                 125             


Ser Gly Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu 
    130                 135                 140                 


Asp Ser Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His 
145                 150                 155                 160 


Glu Ile Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys 
                165                 170                 175     


Lys Thr Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser 
            180                 185                 190         


Asp Gln Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu 
        195                 200                 205             


Asp Asn Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn 
    210                 215                 220                 


Val Thr Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu 
225                 230                 235                 240 


Trp Lys Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala 
                245                 250                 255     


Cys Leu Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu 
            260                 265                 270         


Gln Gln Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys 
        275                 280                 285             


Tyr Thr Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp 
    290                 295                 300                 


Asp Arg Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val 
305                 310                 315                 320 


Val Glu Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val 
                325                 330                 335     


Leu Lys Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys 
            340                 345                 350         


Leu Gln Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys 
        355                 360                 365             


Asp Val Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile 
    370                 375                 380                 


Leu Gly Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly 
385                 390                 395                 400 


Ser Leu Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn 
                405                 410                 415     


Ala Gly Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu 
            420                 425                 430         


His Ser Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile 
        435                 440                 445             


Asp Leu Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser 
    450                 455                 460                 


Gln Leu Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val 
465                 470                 475                 480 


Ala Glu Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg 
                485                 490                 495     


Trp Ala Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr 
            500                 505                 510         


Lys Arg Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu 
        515                 520                 525             


Leu Gly Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe 
    530                 535                 540                 


Cys Lys Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile 
545                 550                 555                 560 


Glu Ser Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn 
                565                 570                 575     


Asp Gly Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu 
            580                 585                 590         


Leu Lys Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser 
        595                 600                 605             


Ser Arg Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn 
    610                 615                 620                 


Gly Gly Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu 
625                 630                 635                 640 


Leu Ser Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met 
                645                 650                 655     


Ala Ala Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn 
            660                 665                 670         


Ile Asp Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu 
        675                 680                 685             


Ala Pro Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile 
    690                 695                 700                 


Lys Thr Glu Leu Ile Ser Val Ser Glu Val 
705                 710                 


<210>  374
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  374

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys 
145                 150 


<210>  375
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  375

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Gly Ser Ser Ser Gln Asn Asn Arg Val Ala Glu Cys 
            180                 185                 190         


His 
    


<210>  376
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  376

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg 
65                  70  


<210>  377
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  377

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp 
        35                  40          


<210>  378
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  378

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Cys Ile Glu His 
        115                 120                 125             


Glu Ile Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys 
    130                 135                 140                 


Lys Thr Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser 
145                 150                 155                 160 


Asp Gln Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu 
                165                 170                 175     


Asp Asn Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn 
            180                 185                 190         


Val Thr Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu 
        195                 200                 205             


Trp Lys Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala 
    210                 215                 220                 


Cys Leu Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu 
225                 230                 235                 240 


Gln Gln Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys 
                245                 250                 255     


Tyr Thr Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp 
            260                 265                 270         


Asp Arg Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val 
        275                 280                 285             


Val Glu Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val 
    290                 295                 300                 


Leu Lys Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys 
305                 310                 315                 320 


Leu Gln Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys 
                325                 330                 335     


Asp Val Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile 
            340                 345                 350         


Leu Gly Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly 
        355                 360                 365             


Ser Leu Ala Ala Glu Phe Arg His Leu 
    370                 375         


<210>  379
<211>  572
<212>  PRT
<213>  Homo sapiens

<400>  379

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 
    210                 215                 220                 


Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 
            260                 265                 270         


Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 
        275                 280                 285             


Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 
    290                 295                 300                 


Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 
    450                 455                 460                 


Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu 
465                 470                 475                 480 


Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala 
                485                 490                 495     


Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 
            500                 505                 510         


Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly 
        515                 520                 525             


Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 
    530                 535                 540                 


Val His His Gly Leu His Gln Gln Gly Ala Arg Ala Cys Pro Val Glu 
545                 550                 555                 560 


Gly Pro Ala Ala Gly Asp Leu Pro Ala Ala Val Gln 
                565                 570         


<210>  380
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  380

Arg Gln Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Ser Leu Ser 
1               5                   10                  15      


Ser Phe Arg Arg Pro Leu Cys Pro Leu Trp 
            20                  25      


<210>  381
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  381

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 
    210                 215                 220                 


Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 
            260                 265                 270         


Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 
        275                 280                 285             


Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 
    290                 295                 300                 


Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 
    450                 455                 460                 


Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu 
465                 470                 475                 480 


Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala 
                485                 490                 495     


Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 
            500                 505                 510         


Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly 
        515                 520                 525             


Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 
    530                 535                 540                 


Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser 
545                 550                 555                 560 


Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly 
                565                 570                 575     


Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys 
            580                 585                 590         


Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg 
        595                 600                 605             


Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly 
    610                 615                 620                 


Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser 
625                 630                 635                 640 


Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala 
                645                 650                 655     


Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp 
            660                 665                 670         


Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro 
        675                 680                 685             


Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr 
    690                 695                 700                 


Glu Leu Ile Ser Val Ser Glu Val His Pro Ser Arg Leu Gln Thr Thr 
705                 710                 715                 720 


Asp Asn Leu Leu Pro Met Ser Pro Glu Glu Phe Asp Glu Val Ser Arg 
                725                 730                 735     


Ile Val Gly Ser Val Glu Phe Asp Ser Met Ser Phe 
            740                 745             


<210>  382
<211>  791
<212>  PRT
<213>  Homo sapiens

<400>  382

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 
    210                 215                 220                 


Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 
            260                 265                 270         


Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 
        275                 280                 285             


Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 
    290                 295                 300                 


Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 
    450                 455                 460                 


Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu 
465                 470                 475                 480 


Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala 
                485                 490                 495     


Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 
            500                 505                 510         


Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly 
        515                 520                 525             


Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 
    530                 535                 540                 


Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser 
545                 550                 555                 560 


Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly 
                565                 570                 575     


Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys 
            580                 585                 590         


Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg 
        595                 600                 605             


Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly 
    610                 615                 620                 


Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser 
625                 630                 635                 640 


Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala 
                645                 650                 655     


Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp 
            660                 665                 670         


Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro 
        675                 680                 685             


Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr 
    690                 695                 700                 


Glu Leu Ile Ser Val Ser Glu Val His Pro Ser Arg Leu Gln Thr Thr 
705                 710                 715                 720 


Asp Asn Leu Leu Pro Met Ser Pro Glu Glu Phe Asp Glu Val Ser Arg 
                725                 730                 735     


Ile Val Gly Ser Val Glu Phe Asp Ser Met Val Ser Thr Thr Ala Gly 
            740                 745                 750         


Leu Cys Val Ala Leu Asn Lys Cys Val Cys Ser Glu Ala Gly Ser Ala 
        755                 760                 765             


Pro Trp Gln Ile Pro Gly Leu Ser Ala Gly Gly Ser Pro Gly Gly Ala 
    770                 775                 780                 


Lys Glu Ser Ala Val Leu Arg 
785                 790     


<210>  383
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  383

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 
    210                 215                 220                 


Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 
            260                 265                 270         


Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 
        275                 280                 285             


Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 
    290                 295                 300                 


Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Arg Asn Thr Val Lys Gly Lys Phe Asn Ile Leu Gly Thr His 
    370                 375                 380                 


Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu Ala Ala 
385                 390                 395                 400 


Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly Thr Arg 
                405                 410                 415     


Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser Leu Ser 
            420                 425                 430         


Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu Glu Thr 
        435                 440                 445             


Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu Pro Ser 
    450                 455                 460                 


Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu Pro Arg 
465                 470                 475                 480 


Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala Gln Leu 
                485                 490                 495     


Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg Gly Leu 
            500                 505                 510         


Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly Pro Asn 
        515                 520                 525             


Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys Glu Asn 
    530                 535                 540                 


Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser Ile Leu 
545                 550                 555                 560 


Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly Cys Ile 
                565                 570                 575     


Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys Asp Gln 
            580                 585                 590         


Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg Glu Gly 
        595                 600                 605             


Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly Glu Pro 
    610                 615                 620                 


Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser Ala Val 
625                 630                 635                 640 


Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala Glu Asn 
                645                 650                 655     


Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp Lys Asp 
            660                 665                 670         


His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro Glu Pro 
        675                 680                 685             


Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr Glu Leu 
    690                 695                 700                 


Ile Ser Val Ser Glu Val His Pro Ser Arg Leu Gln Thr Thr Asp Asn 
705                 710                 715                 720 


Leu Leu Pro Met Ser Pro Glu Glu Phe Asp Glu Val Ser Arg Ile Val 
                725                 730                 735     


Gly Ser Val Glu Phe Asp Ser Met Met Asn Thr Val 
            740                 745             


<210>  384
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  384

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 
    210                 215                 220                 


Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Asn Cys Cys Gly Glu Ser Ala Ala Ser Ser Ala Ala 
            260                 265                 270         


Ala 
    


<210>  385
<211>  716
<212>  PRT
<213>  Homo sapiens

<400>  385

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 
    210                 215                 220                 


Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 
            260                 265                 270         


Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 
        275                 280                 285             


Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 
    290                 295                 300                 


Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 
    450                 455                 460                 


Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu 
465                 470                 475                 480 


Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala 
                485                 490                 495     


Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 
            500                 505                 510         


Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly 
        515                 520                 525             


Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 
    530                 535                 540                 


Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser 
545                 550                 555                 560 


Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly 
                565                 570                 575     


Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys 
            580                 585                 590         


Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg 
        595                 600                 605             


Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly 
    610                 615                 620                 


Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser 
625                 630                 635                 640 


Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala 
                645                 650                 655     


Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp 
            660                 665                 670         


Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro 
        675                 680                 685             


Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr 
    690                 695                 700                 


Glu Leu Ile Ser Val Ser Glu Val Thr Val Leu Gly 
705                 710                 715     


<210>  386
<211>  636
<212>  PRT
<213>  Homo sapiens

<400>  386

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 
    210                 215                 220                 


Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 
            260                 265                 270         


Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 
        275                 280                 285             


Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 
    290                 295                 300                 


Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 
    450                 455                 460                 


Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu 
465                 470                 475                 480 


Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala 
                485                 490                 495     


Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 
            500                 505                 510         


Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly 
        515                 520                 525             


Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 
    530                 535                 540                 


Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser 
545                 550                 555                 560 


Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly 
                565                 570                 575     


Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys 
            580                 585                 590         


Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg 
        595                 600                 605             


Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly 
    610                 615                 620                 


Gly Leu Leu Ser Ala Asp Gln Gly Cys Glu Ser Met 
625                 630                 635     


<210>  387
<211>  779
<212>  PRT
<213>  Homo sapiens

<400>  387

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 
    210                 215                 220                 


Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 
            260                 265                 270         


Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 
        275                 280                 285             


Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 
    290                 295                 300                 


Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 
    450                 455                 460                 


Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu 
465                 470                 475                 480 


Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala 
                485                 490                 495     


Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 
            500                 505                 510         


Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly 
        515                 520                 525             


Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 
    530                 535                 540                 


Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser 
545                 550                 555                 560 


Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly 
                565                 570                 575     


Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys 
            580                 585                 590         


Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg 
        595                 600                 605             


Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly 
    610                 615                 620                 


Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser 
625                 630                 635                 640 


Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala 
                645                 650                 655     


Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp 
            660                 665                 670         


Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro 
        675                 680                 685             


Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr 
    690                 695                 700                 


Glu Leu Ile Ser Val Ser Glu Val His Pro Ser Arg Leu Gln Thr Thr 
705                 710                 715                 720 


Asp Asn Leu Leu Pro Met Ser Pro Glu Glu Phe Asp Glu Val Ser Arg 
                725                 730                 735     


Ile Val Gly Ser Val Glu Phe Asp Ser Met Ala Leu Ala Leu Leu Pro 
            740                 745                 750         


Arg Leu Glu Cys Arg Ala Ala Ile Met Ala His Cys Ser Leu Asp Leu 
        755                 760                 765             


Pro Ser Ser Thr Asp Pro Pro Asn Ser Ala Ser 
    770                 775                 


<210>  388
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  388

Met Ser Ala Ala Gly Ala Arg Gly Leu Arg Ala Thr Tyr His Arg Leu 
1               5                   10                  15      


Leu Asp Lys Val Glu Leu Met Leu Pro Glu Lys Leu Arg Pro Leu Tyr 
            20                  25                  30          


Asn His Pro Ala Gly Pro Arg Thr Val Phe Phe Trp Ala Pro Ile Met 
        35                  40                  45              


Lys Trp Gly Leu Val Cys Ala Gly Leu Ala Asp Met Ala Arg Pro Ala 
    50                  55                  60                  


Glu Lys Leu Ser Thr Ala Gln Ser Ala Val Leu Met Ala Thr Gly Phe 
65                  70                  75                  80  


Ile Trp Ser Arg Tyr Ser Leu Val Ile Ile Pro Lys Asn Trp Ser Leu 
                85                  90                  95      


Phe Ala Val Asn Phe Phe Val Gly Ala Ala Gly Ala Ser Gln Leu Phe 
            100                 105                 110         


Arg Ile Trp Arg Tyr Asn Gln Glu Leu Lys Ala Lys Ala His Lys 
        115                 120                 125         


<210>  389
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  389

Met Ser Ala Ala Gly Ala Arg Gly Leu Arg Ala Thr Tyr His Arg Leu 
1               5                   10                  15      


Leu Asp Lys Val Glu Leu Met Leu Pro Glu Lys Leu Arg Pro Leu Tyr 
            20                  25                  30          


Asn His Pro Ala Gly Pro Arg Thr Val Phe Phe Trp Ala Pro Ile Met 
        35                  40                  45              


Lys Trp Gly Leu Val Cys Ala Gly Leu Ala Asp Met Ala Arg Pro Ala 
    50                  55                  60                  


Glu Lys Leu Ser Thr Ala Gln Ser Ala Val Leu Met Ala Thr Gly Phe 
65                  70                  75                  80  


Ile Trp Ser Arg Tyr Ser Leu Val Ile Ile Pro Lys Asn Trp Ser Leu 
                85                  90                  95      


Phe Ala Val Asn Phe Phe Val Gly Ala 
            100                 105 


<210>  390
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  390

Met Ala Ala Val Val Ala Ala Thr Ala Leu Lys Gly Arg Gly Ala Arg 
1               5                   10                  15      


Asn Ala Arg Val Leu Arg Gly Ile Leu Ala Gly Ala Thr Ala Asn Lys 
            20                  25                  30          


Ala Ser His Asn Arg Thr Arg Ala Leu Gln Ser His Ser Ser Pro Glu 
        35                  40                  45              


Gly Lys Glu Glu Pro Glu Pro Leu Ser Pro Glu Leu Glu Tyr Ile Pro 
    50                  55                  60                  


Arg Lys Arg Gly Lys Asn Pro Met Lys Ala Val Gly Leu Ala Trp Ala 
65                  70                  75                  80  


Ile Gly Phe Pro Cys Gly Ile Leu Leu Phe Ile Leu Thr Lys Arg Glu 
                85                  90                  95      


Val Asp Lys Asp Arg Val Lys Gln Met Lys Ala Arg Gln Asn Met Arg 
            100                 105                 110         


Leu Ser Asn Thr Gly Glu Tyr Glu Ser Gln Arg Phe Arg Ala Ser Ser 
        115                 120                 125             


Gln Ser Ala Pro Ser Pro Asp Val Gly Ser Gly Val Gln Thr 
    130                 135                 140         


<210>  391
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  391

Met Ala Trp Gln Gly Trp Pro Ala Ala Trp Gln Trp Val Ala Gly Cys 
1               5                   10                  15      


Trp Leu Leu Leu Val Leu Val Leu Val Leu Leu Val Ser Pro Arg Gly 
            20                  25                  30          


Cys Arg Ala Arg Arg Gly Leu Arg Gly Leu Leu Met Ala His Ser Gln 
        35                  40                  45              


Arg Leu Leu Phe Arg Ile Gly Tyr Ser Leu Tyr Thr Arg Thr Trp Leu 
    50                  55                  60                  


Gly Tyr Leu Phe Tyr Arg Gln Gln Leu Arg Arg Ala Arg Asn Arg Tyr 
65                  70                  75                  80  


Pro Lys Gly His Ser Lys Thr Gln Pro Arg Leu Phe Asn Gly Val Lys 
                85                  90                  95      


Val Leu Pro Ile Pro Val Leu Ser Asp Asn Tyr Ser Tyr Leu Ile Ile 
            100                 105                 110         


Asp Thr Gln Ala Gln Leu Ala Val Ala Val Asp Pro Ser Asp Pro Arg 
        115                 120                 125             


Ala Val Gln Ala Ser Ile Glu Lys Glu Gly Val Thr Leu Val Ala Ile 
    130                 135                 140                 


Leu Cys Thr His Lys His Trp Asp His Ser Gly Gly Asn Arg Asp Leu 
145                 150                 155                 160 


Ser Arg Arg His Arg Asp Cys Arg Val Tyr Gly Ser Pro Gln Asp Gly 
                165                 170                 175     


Ile Pro Tyr Leu Thr His Pro Leu Cys His Gln Asp Val Val Ser Val 
            180                 185                 190         


Gly Arg Leu Gln Ile Arg Ala Leu Ala Thr Pro Gly His Thr Gln Gly 
        195                 200                 205             


His Leu Val Tyr Leu Leu Asp Gly Glu Pro Tyr Lys Gly Pro Ser Cys 
    210                 215                 220                 


Leu Phe Ser Gly Asp Leu Leu Phe Leu Ser Gly Cys Gly Arg Thr Phe 
225                 230                 235                 240 


Glu Gly Asn Ala Glu Thr Met Leu Ser Ser Leu Asp Thr Val Leu Gly 
                245                 250                 255     


Leu Gly Asp Asp Thr Leu Leu Trp Pro Gly His Glu Tyr Ala Glu Glu 
            260                 265                 270         


Asn Leu Gly Phe Ala Gly Val Val Glu Pro Glu Asn Leu Ala Arg Glu 
        275                 280                 285             


Arg Lys Met Gln Trp Val Gln Arg Gln Arg Leu Glu Arg Lys Gly Thr 
    290                 295                 300                 


Cys Pro Ser Thr Leu Gly Glu Glu Arg Ser Tyr Asn Pro Phe Leu Arg 
305                 310                 315                 320 


Thr His Cys Leu Ala Leu Gln Glu Ala Leu Gly Pro Gly Pro Gly Pro 
                325                 330                 335     


Thr Gly Asp Asp Asp Tyr Ser Arg Ala Gln Leu Leu Glu Glu Leu Arg 
            340                 345                 350         


Arg Leu Lys Asp Met His Lys Ser Lys 
        355                 360     


<210>  392
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  392

Met Ala Ala Val Val Ala Ala Thr Ala Leu Lys Gly Arg Gly Ala Arg 
1               5                   10                  15      


Asn Ala Arg Val Leu Arg Gly Ile Leu Ala Gly Ala Thr Ala Asn Lys 
            20                  25                  30          


Ala Ser His Asn Arg Thr Arg Ala Leu Gln Ser His Ser Ser Pro Glu 
        35                  40                  45              


Gly Lys Glu Glu Pro Glu Pro Leu Ser Pro Glu Leu Glu Tyr Ile Pro 
    50                  55                  60                  


Arg Lys Arg Gly Lys Asn Pro Met Lys Ala Val Gly Leu Ala Trp Tyr 
65                  70                  75                  80  


Ser Leu Tyr Thr Arg Thr Trp Leu Gly Tyr Leu Phe Tyr Arg Gln Gln 
                85                  90                  95      


Leu Arg Arg Ala Arg Asn Arg Tyr Pro Lys Gly His Ser Lys Thr Gln 
            100                 105                 110         


Pro Arg Leu Phe Asn Gly Val Lys Val Leu Pro Ile Pro Val Leu Ser 
        115                 120                 125             


Asp Asn Tyr Ser Tyr Leu Ile Ile Asp Thr Gln Ala Gln Leu Ala Val 
    130                 135                 140                 


Ala Val Asp Pro Ser Asp Pro Arg Ala Val Gln Ala Ser Ile Glu Lys 
145                 150                 155                 160 


Glu Gly Val Thr Leu Val Ala Ile Leu Cys Thr His Lys His Trp Asp 
                165                 170                 175     


His Ser Gly Gly Asn Arg Asp Leu Ser Arg Arg His Arg Asp Cys Arg 
            180                 185                 190         


Val Tyr Gly Ser Pro Gln Asp Gly Ile Pro Tyr Leu Thr His Pro Leu 
        195                 200                 205             


Cys His Gln Asp Val Val Ser Val Gly Arg Leu Gln Ile Arg Ala Leu 
    210                 215                 220                 


Ala Thr Pro Gly His Thr Gln Gly His Leu Val Tyr Leu Leu Asp Gly 
225                 230                 235                 240 


Glu Pro Tyr Lys Gly Pro Ser Cys Leu Phe Ser Gly Asp Leu Leu Phe 
                245                 250                 255     


Leu Ser Gly Cys Gly Arg Thr Phe Glu Gly Asn Ala Glu Thr Met Leu 
            260                 265                 270         


Ser Ser Leu Asp Thr Val Leu Gly Leu Gly Asp Asp Thr Leu Leu Trp 
        275                 280                 285             


Pro Gly His Glu Tyr Ala Glu Glu Asn Leu Gly Phe Ala Gly Val Val 
    290                 295                 300                 


Glu Pro Glu Asn Leu Ala Arg Glu Arg Lys Met Gln Trp Val Gln Arg 
305                 310                 315                 320 


Gln Arg Leu Glu Arg Lys Gly Thr Cys Pro Ser Thr Leu Gly Glu Glu 
                325                 330                 335     


Arg Ser Tyr Asn Pro Phe Leu Arg Thr His Cys Leu Ala Leu Gln Glu 
            340                 345                 350         


Ala Leu Gly Pro Gly Pro Gly Pro Thr Gly Asp Asp Asp Tyr Ser Arg 
        355                 360                 365             


Ala Gln Leu Leu Glu Glu Leu Arg Arg Leu Lys Asp Met His Lys Ser 
    370                 375                 380                 


Lys 
385 


<210>  393
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  393

Met Pro Ser Ser Val His His Thr Lys Arg Gln Met Met Ser Ile Tyr 
1               5                   10                  15      


Cys Tyr Trp Tyr Ser Leu Tyr Thr Arg Thr Trp Leu Gly Tyr Leu Phe 
            20                  25                  30          


Tyr Arg Gln Gln Leu Arg Arg Ala Arg Asn Arg Tyr Pro Lys Gly His 
        35                  40                  45              


Ser Lys Thr Gln Pro Arg Leu Phe Asn Gly Val Lys Val Leu Pro Ile 
    50                  55                  60                  


Pro Val Leu Ser Asp Asn Tyr Ser Tyr Leu Ile Ile Asp Thr Gln Ala 
65                  70                  75                  80  


Gln Leu Ala Val Ala Val Asp Pro Ser Asp Pro Arg Ala Val Gln Ala 
                85                  90                  95      


Ser Ile Glu Lys Glu Gly Val Thr Leu Val Ala Ile Leu Cys Thr His 
            100                 105                 110         


Lys His Trp Asp His Ser Gly Gly Asn Arg Asp Leu Ser Arg Arg His 
        115                 120                 125             


Arg Asp Cys Arg Val Tyr Gly Ser Pro Gln Asp Gly Ile Pro Tyr Leu 
    130                 135                 140                 


Thr His Pro Leu Cys His Gln Asp Val Val Ser Val Gly Arg Leu Gln 
145                 150                 155                 160 


Ile Arg Ala Leu Ala Thr Pro Gly His Thr Gln Gly His Leu Val Tyr 
                165                 170                 175     


Leu Leu Asp Gly Glu Pro Tyr Lys Gly Pro Ser Cys Leu Phe Ser Gly 
            180                 185                 190         


Asp Leu Leu Phe Leu Ser Gly Cys Gly Arg Thr Phe Glu Gly Asn Ala 
        195                 200                 205             


Glu Thr Met Leu Ser Ser Leu Asp Thr Val Leu Gly Leu Gly Asp Asp 
    210                 215                 220                 


Thr Leu Leu Trp Pro Gly His Glu Tyr Ala Glu Glu Asn Leu Gly Phe 
225                 230                 235                 240 


Ala Gly Val Val Glu Pro Glu Asn Leu Ala Arg Glu Arg Lys Met Gln 
                245                 250                 255     


Trp Val Gln Arg Gln Arg Leu Glu Arg Lys Gly Thr Cys Pro Ser Thr 
            260                 265                 270         


Leu Gly Glu Glu Arg Ser Tyr Asn Pro Phe Leu Arg Thr His Cys Leu 
        275                 280                 285             


Ala Leu Gln Glu Ala Leu Gly Pro Gly Pro Gly Pro Thr Gly Asp Asp 
    290                 295                 300                 


Asp Tyr Ser Arg Ala Gln Leu Leu Glu Glu Leu Arg Arg Leu Lys Asp 
305                 310                 315                 320 


Met His Lys Ser Lys 
                325 


<210>  394
<211>  720
<212>  PRT
<213>  Homo sapiens

<400>  394

Met Asn Asn His Val Ser Ser Lys Pro Ser Thr Met Lys Leu Lys His 
1               5                   10                  15      


Thr Ile Asn Pro Ile Leu Leu Tyr Phe Ile His Phe Leu Ile Ser Leu 
            20                  25                  30          


Tyr Thr Ile Leu Thr Tyr Ile Pro Phe Tyr Phe Phe Ser Glu Ser Arg 
        35                  40                  45              


Gln Glu Lys Ser Asn Arg Ile Lys Ala Lys Pro Val Asn Ser Lys Pro 
    50                  55                  60                  


Asp Ser Ala Tyr Arg Ser Val Asn Ser Leu Asp Gly Leu Ala Ser Val 
65                  70                  75                  80  


Leu Tyr Pro Gly Cys Asp Thr Leu Asp Lys Val Phe Thr Tyr Ala Lys 
                85                  90                  95      


Asn Lys Phe Lys Asn Lys Arg Leu Leu Gly Thr Arg Glu Val Leu Asn 
            100                 105                 110         


Glu Glu Asp Glu Val Gln Pro Asn Gly Lys Ile Phe Lys Lys Val Ile 
        115                 120                 125             


Leu Gly Gln Tyr Asn Trp Leu Ser Tyr Glu Asp Val Phe Val Arg Ala 
    130                 135                 140                 


Phe Asn Phe Gly Asn Gly Leu Gln Met Leu Gly Gln Lys Pro Lys Thr 
145                 150                 155                 160 


Asn Ile Ala Ile Phe Cys Glu Thr Arg Ala Glu Trp Met Ile Ala Ala 
                165                 170                 175     


Gln Ala Cys Phe Met Tyr Asn Phe Gln Leu Val Thr Leu Tyr Ala Thr 
            180                 185                 190         


Leu Gly Gly Pro Ala Ile Val His Ala Leu Asn Glu Thr Glu Val Thr 
        195                 200                 205             


Asn Ile Ile Thr Ser Lys Glu Leu Leu Gln Thr Lys Leu Lys Asp Ile 
    210                 215                 220                 


Val Ser Leu Val Pro Arg Leu Arg His Ile Ile Thr Val Asp Gly Lys 
225                 230                 235                 240 


Pro Pro Thr Trp Ser Glu Phe Pro Lys Gly Ile Ile Val His Thr Met 
                245                 250                 255     


Ala Ala Val Glu Ala Leu Gly Ala Lys Ala Ser Met Glu Asn Gln Pro 
            260                 265                 270         


His Ser Lys Pro Leu Pro Ser Asp Ile Ala Val Ile Met Tyr Thr Ser 
        275                 280                 285             


Gly Ser Thr Gly Leu Pro Lys Gly Val Met Ile Ser His Ser Asn Ile 
    290                 295                 300                 


Ile Ala Gly Ile Thr Gly Met Ala Glu Arg Ile Pro Glu Leu Gly Glu 
305                 310                 315                 320 


Glu Asp Val Tyr Ile Gly Tyr Leu Pro Leu Ala His Val Leu Glu Leu 
                325                 330                 335     


Ser Ala Glu Leu Val Cys Leu Ser His Gly Cys Arg Ile Gly Tyr Ser 
            340                 345                 350         


Ser Pro Gln Thr Leu Ala Asp Gln Ser Ser Lys Ile Lys Lys Gly Ser 
        355                 360                 365             


Lys Gly Asp Thr Ser Met Leu Lys Pro Thr Leu Met Ala Ala Val Pro 
    370                 375                 380                 


Glu Ile Met Asp Arg Ile Tyr Lys Asn Val Met Asn Lys Val Ser Glu 
385                 390                 395                 400 


Met Ser Ser Phe Gln Arg Asn Leu Phe Ile Leu Ala Tyr Asn Tyr Lys 
                405                 410                 415     


Met Glu Gln Ile Ser Lys Gly Arg Asn Thr Pro Leu Cys Asp Ser Phe 
            420                 425                 430         


Val Phe Arg Lys Val Arg Ser Leu Leu Gly Gly Asn Ile Arg Leu Leu 
        435                 440                 445             


Leu Cys Gly Gly Ala Pro Leu Ser Ala Thr Thr Gln Arg Phe Met Asn 
    450                 455                 460                 


Ile Cys Phe Cys Cys Pro Val Gly Gln Gly Tyr Gly Leu Thr Glu Ser 
465                 470                 475                 480 


Ala Gly Ala Gly Thr Ile Ser Glu Val Trp Asp Tyr Asn Thr Gly Arg 
                485                 490                 495     


Val Gly Ala Pro Leu Val Cys Cys Glu Ile Lys Leu Lys Asn Trp Glu 
            500                 505                 510         


Glu Gly Gly Tyr Phe Asn Thr Asp Lys Pro His Pro Arg Gly Glu Ile 
        515                 520                 525             


Leu Ile Gly Gly Gln Ser Val Thr Met Gly Tyr Tyr Lys Asn Glu Ala 
    530                 535                 540                 


Lys Thr Lys Ala Asp Phe Phe Glu Asp Glu Asn Gly Gln Arg Trp Leu 
545                 550                 555                 560 


Cys Thr Gly Asp Ile Gly Glu Phe Glu Pro Asp Gly Cys Leu Lys Ile 
                565                 570                 575     


Ile Asp Arg Lys Lys Asp Leu Val Lys Leu Gln Ala Gly Glu Tyr Val 
            580                 585                 590         


Ser Leu Gly Lys Val Glu Ala Ala Leu Lys Asn Leu Pro Leu Val Asp 
        595                 600                 605             


Asn Ile Cys Ala Tyr Ala Asn Ser Tyr His Ser Tyr Val Ile Gly Phe 
    610                 615                 620                 


Val Val Pro Asn Gln Lys Glu Leu Thr Glu Leu Ala Arg Lys Lys Gly 
625                 630                 635                 640 


Leu Lys Gly Thr Trp Glu Glu Leu Cys Asn Ser Cys Glu Met Glu Asn 
                645                 650                 655     


Glu Val Leu Lys Val Leu Ser Glu Ala Ala Ile Ser Ala Ser Leu Glu 
            660                 665                 670         


Lys Phe Glu Ile Pro Val Lys Ile Arg Leu Ser Pro Glu Pro Trp Thr 
        675                 680                 685             


Pro Glu Thr Gly Leu Val Thr Asp Ala Phe Lys Leu Lys Arg Lys Glu 
    690                 695                 700                 


Leu Lys Thr His Tyr Gln Ala Asp Ile Glu Arg Met Tyr Gly Arg Lys 
705                 710                 715                 720 


<210>  395
<211>  18
<212>  PRT
<213>  Ensifer sp.


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  395

Xaa Glu Gln Ile Ser Lys Gly Arg Asn Thr Pro Leu Cys Asp Arg Trp 
1               5                   10                  15      


Ile Leu 
        


<210>  396
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  396

Met Asn Asn His Val Ser Ser Lys Pro Ser Thr Met Lys Leu Lys His 
1               5                   10                  15      


Thr Ile Asn Pro Ile Leu Leu Tyr Phe Ile His Phe Leu Ile Ser Leu 
            20                  25                  30          


Tyr Thr Ile Leu Thr Tyr Ile Pro Phe Tyr Phe Phe Ser Glu Ser Arg 
        35                  40                  45              


Gln Glu Lys Ser Asn Arg Ile Lys Ala Lys Pro Val Asn Ser Lys Pro 
    50                  55                  60                  


Asp Ser Ala Tyr Arg Ser Val Asn Ser Leu Asp Gly Leu Ala Ser Val 
65                  70                  75                  80  


Leu Tyr Pro Gly Cys Asp Thr Leu 
                85              


<210>  397
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  397

Met Asn Asn His Val Ser Ser Lys Pro Ser Thr Met Lys Leu Lys His 
1               5                   10                  15      


Thr Ile Asn Pro Ile Leu Leu Tyr Phe Ile His Phe Leu Ile Ser Leu 
            20                  25                  30          


Tyr Thr Ile Leu Thr Tyr Ile Pro Phe Tyr Phe Phe Ser Glu Ser Arg 
        35                  40                  45              


Gln Glu Lys Ser Asn Arg Ile Lys Ala Lys Pro Val Asn Ser Lys Pro 
    50                  55                  60                  


Asp Ser Ala Tyr Arg Ser Val Asn Ser Leu Asp Gly Leu Ala Ser Val 
65                  70                  75                  80  


Leu Tyr Pro Gly Cys Asp Thr Leu Asp Lys Val Phe Thr Tyr Ala 
                85                  90                  95  


<210>  398
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  398

Met Leu Gly Gln Lys Pro Lys Thr Asn Ile Ala Ile Phe Cys Glu Thr 
1               5                   10                  15      


Arg Ala Glu Trp Met Ile Ala Ala Gln Ala Cys Phe Met Tyr Asn Phe 
            20                  25                  30          


Gln Leu Val Thr Leu Tyr Ala Thr Leu Gly Gly Pro Ala Ile Val His 
        35                  40                  45              


Ala Leu Asn Glu Thr Glu Val Thr Asn Ile Ile Thr Ser Lys Glu Leu 
    50                  55                  60                  


Leu Gln Thr Lys Leu Lys Asp Ile Val Ser Leu Val Pro Arg Leu Arg 
65                  70                  75                  80  


His Ile Ile Thr Val Asp Gly Lys Pro Pro Thr Trp Ser Glu Phe Pro 
                85                  90                  95      


Lys Gly Ile Ile Val His Thr Met Ala Ala Val Glu Ala Leu Gly Ala 
            100                 105                 110         


Lys Ala Ser Met Glu Asn Gln Pro His Ser Lys Pro Leu Pro Ser Asp 
        115                 120                 125             


Ile Ala Val Ile Met Tyr Thr Ser Gly Ser Thr Gly Leu 
    130                 135                 140     


<210>  399
<211>  1084
<212>  PRT
<213>  Homo sapiens

<400>  399

Met Ser Ser Gln Ser His Pro Asp Gly Leu Ser Gly Arg Asp Gln Pro 
1               5                   10                  15      


Val Glu Leu Leu Asn Pro Ala Arg Val Asn His Met Pro Ser Thr Val 
            20                  25                  30          


Asp Val Ala Thr Ala Leu Pro Leu Gln Val Ala Pro Ser Ala Val Pro 
        35                  40                  45              


Met Asp Leu Arg Leu Asp His Gln Phe Ser Leu Pro Val Ala Glu Pro 
    50                  55                  60                  


Ala Leu Arg Glu Gln Gln Leu Gln Gln Glu Leu Leu Ala Leu Lys Gln 
65                  70                  75                  80  


Lys Gln Gln Ile Gln Arg Gln Ile Leu Ile Ala Glu Phe Gln Arg Gln 
                85                  90                  95      


His Glu Gln Leu Ser Arg Gln His Glu Ala Gln Leu His Glu His Ile 
            100                 105                 110         


Lys Gln Gln Gln Glu Met Leu Ala Met Lys His Gln Gln Glu Leu Leu 
        115                 120                 125             


Glu His Gln Arg Lys Leu Glu Arg His Arg Gln Glu Gln Glu Leu Glu 
    130                 135                 140                 


Lys Gln His Arg Glu Gln Lys Leu Gln Gln Leu Lys Asn Lys Glu Lys 
145                 150                 155                 160 


Gly Lys Glu Ser Ala Val Ala Ser Thr Glu Val Lys Met Lys Leu Gln 
                165                 170                 175     


Glu Phe Val Leu Asn Lys Lys Lys Ala Leu Ala His Arg Asn Leu Asn 
            180                 185                 190         


His Cys Ile Ser Ser Asp Pro Arg Tyr Trp Tyr Gly Lys Thr Gln His 
        195                 200                 205             


Ser Ser Leu Asp Gln Ser Ser Pro Pro Gln Ser Gly Val Ser Thr Ser 
    210                 215                 220                 


Tyr Asn His Pro Val Leu Gly Met Tyr Asp Ala Lys Asp Asp Phe Pro 
225                 230                 235                 240 


Leu Arg Lys Thr Ala Ser Glu Pro Asn Leu Lys Leu Arg Ser Arg Leu 
                245                 250                 255     


Lys Gln Lys Val Ala Glu Arg Arg Ser Ser Pro Leu Leu Arg Arg Lys 
            260                 265                 270         


Asp Gly Pro Val Val Thr Ala Leu Lys Lys Arg Pro Leu Asp Val Thr 
        275                 280                 285             


Asp Ser Ala Cys Ser Ser Ala Pro Gly Ser Gly Pro Ser Ser Pro Asn 
    290                 295                 300                 


Asn Ser Ser Gly Ser Val Ser Ala Glu Asn Gly Ile Ala Pro Ala Val 
305                 310                 315                 320 


Pro Ser Ile Pro Ala Glu Thr Ser Leu Ala His Arg Leu Val Ala Arg 
                325                 330                 335     


Glu Gly Ser Ala Ala Pro Leu Pro Leu Tyr Thr Ser Pro Ser Leu Pro 
            340                 345                 350         


Asn Ile Thr Leu Gly Leu Pro Ala Thr Gly Pro Ser Ala Gly Thr Ala 
        355                 360                 365             


Gly Gln Gln Asp Ala Glu Arg Leu Thr Leu Pro Ala Leu Gln Gln Arg 
    370                 375                 380                 


Leu Ser Leu Phe Pro Gly Thr His Leu Thr Pro Tyr Leu Ser Thr Ser 
385                 390                 395                 400 


Pro Leu Glu Arg Asp Gly Gly Ala Ala His Ser Pro Leu Leu Gln His 
                405                 410                 415     


Met Val Leu Leu Glu Gln Pro Pro Ala Gln Ala Pro Leu Val Thr Gly 
            420                 425                 430         


Leu Gly Ala Leu Pro Leu His Ala Gln Ser Leu Val Gly Ala Asp Arg 
        435                 440                 445             


Val Ser Pro Ser Ile His Lys Leu Arg Gln His Arg Pro Leu Gly Arg 
    450                 455                 460                 


Thr Gln Ser Ala Pro Leu Pro Gln Asn Ala Gln Ala Leu Gln His Leu 
465                 470                 475                 480 


Val Ile Gln Gln Gln His Gln Gln Phe Leu Glu Lys His Lys Gln Gln 
                485                 490                 495     


Phe Gln Gln Gln Gln Leu Gln Met Asn Lys Ile Ile Pro Lys Pro Ser 
            500                 505                 510         


Glu Pro Ala Arg Gln Pro Glu Ser His Pro Glu Glu Thr Glu Glu Glu 
        515                 520                 525             


Leu Arg Glu His Gln Ala Leu Leu Asp Glu Pro Tyr Leu Asp Arg Leu 
    530                 535                 540                 


Pro Gly Gln Lys Glu Ala His Ala Gln Ala Gly Val Gln Val Lys Gln 
545                 550                 555                 560 


Glu Pro Ile Glu Ser Asp Glu Glu Glu Ala Glu Pro Pro Arg Glu Val 
                565                 570                 575     


Glu Pro Gly Gln Arg Gln Pro Ser Glu Gln Glu Leu Leu Phe Arg Gln 
            580                 585                 590         


Gln Ala Leu Leu Leu Glu Gln Gln Arg Ile His Gln Leu Arg Asn Tyr 
        595                 600                 605             


Gln Ala Ser Met Glu Ala Ala Gly Ile Pro Val Ser Phe Gly Gly His 
    610                 615                 620                 


Arg Pro Leu Ser Arg Ala Gln Ser Ser Pro Ala Ser Ala Thr Phe Pro 
625                 630                 635                 640 


Val Ser Val Gln Glu Pro Pro Thr Lys Pro Arg Phe Thr Thr Gly Leu 
                645                 650                 655     


Val Tyr Asp Thr Leu Met Leu Lys His Gln Cys Thr Cys Gly Ser Ser 
            660                 665                 670         


Ser Ser His Pro Glu His Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg 
        675                 680                 685             


Leu Gln Glu Thr Gly Leu Arg Gly Lys Cys Glu Cys Ile Arg Gly Arg 
    690                 695                 700                 


Lys Ala Thr Leu Glu Glu Leu Gln Thr Val His Ser Glu Ala His Thr 
705                 710                 715                 720 


Leu Leu Tyr Gly Thr Asn Pro Leu Asn Arg Gln Lys Leu Asp Ser Lys 
                725                 730                 735     


Lys Leu Leu Gly Ser Leu Ala Ser Val Phe Val Arg Leu Pro Cys Gly 
            740                 745                 750         


Gly Val Gly Val Asp Ser Asp Thr Ile Trp Asn Glu Val His Ser Ala 
        755                 760                 765             


Gly Ala Ala Arg Leu Ala Val Gly Cys Val Val Glu Leu Val Phe Lys 
    770                 775                 780                 


Val Ala Thr Gly Glu Leu Lys Asn Gly Phe Ala Val Val Arg Pro Pro 
785                 790                 795                 800 


Gly His His Ala Glu Glu Ser Thr Pro Met Gly Phe Cys Tyr Phe Asn 
                805                 810                 815     


Ser Val Ala Val Ala Ala Lys Leu Leu Gln Gln Arg Leu Ser Val Ser 
            820                 825                 830         


Lys Ile Leu Ile Val Asp Trp Asp Val His His Gly Asn Gly Thr Gln 
        835                 840                 845             


Gln Ala Phe Tyr Ser Asp Pro Ser Val Leu Tyr Met Ser Leu His Arg 
    850                 855                 860                 


Tyr Asp Asp Gly Asn Phe Phe Pro Gly Ser Gly Ala Pro Asp Glu Val 
865                 870                 875                 880 


Gly Thr Gly Pro Gly Val Gly Phe Asn Val Asn Met Ala Phe Thr Gly 
                885                 890                 895     


Gly Leu Asp Pro Pro Met Gly Asp Ala Glu Tyr Leu Ala Ala Phe Arg 
            900                 905                 910         


Thr Val Val Met Pro Ile Ala Ser Glu Phe Ala Pro Asp Val Val Leu 
        915                 920                 925             


Val Ser Ser Gly Phe Asp Ala Val Glu Gly His Pro Thr Pro Leu Gly 
    930                 935                 940                 


Gly Tyr Asn Leu Ser Ala Arg Cys Phe Gly Tyr Leu Thr Lys Gln Leu 
945                 950                 955                 960 


Met Gly Leu Ala Gly Gly Arg Ile Val Leu Ala Leu Glu Gly Gly His 
                965                 970                 975     


Asp Leu Thr Ala Ile Cys Asp Ala Ser Glu Ala Cys Val Ser Ala Leu 
            980                 985                 990         


Leu Gly Asn Glu Leu Asp Pro Leu  Pro Glu Lys Val Leu  Gln Gln Arg 
        995                 1000                 1005             


Pro Asn  Ala Asn Ala Val Arg  Ser Met Glu Lys Val  Met Glu Ile 
    1010                 1015                 1020             


His Ser  Lys Tyr Trp Arg Cys  Leu Gln Arg Thr Thr  Ser Thr Ala 
    1025                 1030                 1035             


Gly Arg  Ser Leu Ile Glu Ala  Gln Thr Cys Glu Asn  Glu Glu Ala 
    1040                 1045                 1050             


Glu Thr  Val Thr Ala Met Ala  Ser Leu Ser Val Gly  Val Lys Pro 
    1055                 1060                 1065             


Ala Glu  Lys Arg Pro Asp Glu  Glu Pro Met Glu Glu  Glu Pro Pro 
    1070                 1075                 1080             


Leu 
    


<210>  400
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  400

Met Pro Ser Thr Val Asp Val Ala Thr Ala Leu Pro Leu Gln Val Ala 
1               5                   10                  15      


Pro Ser Ala Val Pro Met Asp Leu Arg Leu Asp His Gln Phe Ser Leu 
            20                  25                  30          


Pro Val Ala Glu Pro Ala Leu Arg Glu Gln Gln Leu Gln Gln Glu Leu 
        35                  40                  45              


Leu Ala Leu Lys Gln Lys Gln Gln Ile Gln Arg Gln Ile Leu Ile Ala 
    50                  55                  60                  


Glu Phe Gln Arg Gln His Glu Gln Leu Ser Arg Gln His Glu Ala Gln 
65                  70                  75                  80  


Leu His Glu His Ile Lys Gln Gln Gln Glu Met Leu Ala Met Lys His 
                85                  90                  95      


Gln Gln Glu Leu Leu Glu His Gln Arg Lys Leu Glu Arg His Arg Gln 
            100                 105                 110         


Glu Gln Glu Leu Glu Lys Gln His Arg Glu Gln 
        115                 120             


<210>  401
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  401

Met Asp Val Ala Thr Ala Leu Pro Leu Gln Val Ala Pro Ser Ala Val 
1               5                   10                  15      


Pro Met Asp Leu Arg Leu Asp His Gln Phe Ser Leu Pro Val Ala Glu 
            20                  25                  30          


Pro Ala Leu Arg Glu Gln Gln Leu Gln Gln Glu Leu Leu Ala Leu Lys 
        35                  40                  45              


Gln Lys Gln Gln Ile Gln Arg Gln Ile Leu Ile Ala Glu Phe Gln Arg 
    50                  55                  60                  


Gln His Glu Gln Leu Ser Arg Gln His Glu Ala Gln Leu His Glu His 
65                  70                  75                  80  


Ile Lys Gln Gln Gln Glu Met Leu Ala Met Lys His Gln Gln Glu Leu 
                85                  90                  95      


Leu Glu His Gln Arg Lys Leu Glu Arg His Arg Gln Glu Gln Glu Leu 
            100                 105                 110         


Glu Lys Gln His Arg Glu Gln Lys Leu Gln Gln Leu Lys Asn Lys Glu 
        115                 120                 125             


Lys Gly Lys Glu Ser Ala Val Ala Ser Thr Glu Val Lys Met Lys Leu 
    130                 135                 140                 


Gln Glu Phe Val Leu Asn Lys Lys Lys Ala Leu Ala His Arg Asn Leu 
145                 150                 155                 160 


Asn His 
        


<210>  402
<211>  175
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  402

Xaa Ala Trp Pro Cys Val Ser Thr Pro Gln Pro Pro Val Phe Leu Arg 
1               5                   10                  15      


Cys His Glu Thr Arg Phe Trp Ala Val Leu Ala Ala Val Leu Pro Arg 
            20                  25                  30          


Ser His Cys Ser Leu Pro Phe Pro Val Ala Gly Phe Gly Tyr Leu Thr 
        35                  40                  45              


Lys Gln Leu Met Gly Leu Ala Gly Gly Arg Ile Val Leu Ala Leu Glu 
    50                  55                  60                  


Gly Gly His Asp Leu Thr Ala Ile Cys Asp Ala Ser Glu Ala Cys Val 
65                  70                  75                  80  


Ser Ala Leu Leu Gly Asn Glu Leu Asp Pro Leu Pro Glu Lys Val Leu 
                85                  90                  95      


Gln Gln Arg Pro Asn Ala Asn Ala Val Arg Ser Met Glu Lys Val Met 
            100                 105                 110         


Glu Ile His Ser Lys Tyr Trp Arg Cys Leu Gln Arg Thr Thr Ser Thr 
        115                 120                 125             


Ala Gly Arg Ser Leu Ile Glu Ala Gln Thr Cys Glu Asn Glu Glu Ala 
    130                 135                 140                 


Glu Thr Val Thr Ala Met Ala Ser Leu Ser Val Gly Val Lys Pro Ala 
145                 150                 155                 160 


Glu Lys Arg Pro Asp Glu Glu Pro Met Glu Glu Glu Pro Pro Leu 
                165                 170                 175 


<210>  403
<211>  148
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  403

Xaa Trp Leu Tyr Leu Phe Pro His Pro Pro His Pro Pro His Cys Gly 
1               5                   10                  15      


Ser Gly Leu Tyr Leu Gln Ser His His Leu Gln Gln Ala Trp Ile Pro 
            20                  25                  30          


His Ser Ala Cys Ser Ser Ala Pro Gly Ser Gly Pro Ser Ser Pro Asn 
        35                  40                  45              


Asn Ser Ser Gly Ser Val Ser Ala Glu Asn Gly Ile Ala Pro Ala Val 
    50                  55                  60                  


Pro Ser Ile Pro Ala Glu Thr Ser Leu Ala His Arg Leu Val Ala Arg 
65                  70                  75                  80  


Glu Gly Ser Ala Ala Pro Leu Pro Leu Tyr Thr Ser Pro Ser Leu Pro 
                85                  90                  95      


Asn Ile Thr Leu Gly Leu Pro Ala Thr Gly Pro Ser Ala Gly Thr Ala 
            100                 105                 110         


Gly Gln Gln Asp Ala Glu Arg Leu Thr Leu Pro Ala Leu Gln Gln Arg 
        115                 120                 125             


Leu Ser Leu Phe Pro Gly Thr His Leu Thr Pro Tyr Leu Ser Thr Ser 
    130                 135                 140                 


Pro Leu Glu Arg 
145             


<210>  404
<211>  1089
<212>  PRT
<213>  Homo sapiens

<400>  404

Met Ser Ser Gln Ser His Pro Asp Gly Leu Ser Gly Arg Asp Gln Pro 
1               5                   10                  15      


Val Glu Leu Leu Asn Pro Ala Arg Val Asn His Met Pro Ser Thr Val 
            20                  25                  30          


Asp Val Ala Thr Ala Leu Pro Leu Gln Val Ala Pro Ser Ala Val Pro 
        35                  40                  45              


Met Asp Leu Arg Leu Asp His Gln Phe Ser Leu Pro Val Ala Glu Pro 
    50                  55                  60                  


Ala Leu Arg Glu Gln Gln Leu Gln Gln Glu Leu Leu Ala Leu Lys Gln 
65                  70                  75                  80  


Lys Gln Gln Ile Gln Arg Gln Ile Leu Ile Ala Glu Phe Gln Arg Gln 
                85                  90                  95      


His Glu Gln Leu Ser Arg Gln His Glu Ala Gln Leu His Glu His Ile 
            100                 105                 110         


Lys Gln Gln Gln Glu Met Leu Ala Met Lys His Gln Gln Glu Leu Leu 
        115                 120                 125             


Glu His Gln Arg Lys Leu Glu Arg His Arg Gln Glu Gln Glu Leu Glu 
    130                 135                 140                 


Lys Gln His Arg Glu Gln Lys Leu Gln Gln Leu Lys Asn Lys Glu Lys 
145                 150                 155                 160 


Gly Lys Glu Ser Ala Val Ala Ser Thr Glu Val Lys Met Lys Leu Gln 
                165                 170                 175     


Glu Phe Val Leu Asn Lys Lys Lys Ala Leu Ala His Arg Asn Leu Asn 
            180                 185                 190         


His Cys Ile Ser Ser Asp Pro Arg Tyr Trp Tyr Gly Lys Thr Gln His 
        195                 200                 205             


Ser Ser Leu Asp Gln Ser Ser Pro Pro Gln Ser Gly Val Ser Thr Ser 
    210                 215                 220                 


Tyr Asn His Pro Val Leu Gly Met Tyr Asp Ala Lys Asp Asp Phe Pro 
225                 230                 235                 240 


Leu Arg Lys Thr Ala Ser Glu Pro Asn Leu Lys Leu Arg Ser Arg Leu 
                245                 250                 255     


Lys Gln Lys Val Ala Glu Arg Arg Ser Ser Pro Leu Leu Arg Arg Lys 
            260                 265                 270         


Asp Gly Pro Val Val Thr Ala Leu Lys Lys Arg Pro Leu Asp Val Thr 
        275                 280                 285             


Asp Ser Ala Cys Ser Ser Ala Pro Gly Ser Gly Pro Ser Ser Pro Asn 
    290                 295                 300                 


Asn Ser Ser Gly Ser Val Ser Ala Glu Asn Gly Ile Ala Pro Ala Val 
305                 310                 315                 320 


Pro Ser Ile Pro Ala Glu Thr Ser Leu Ala His Arg Leu Val Ala Arg 
                325                 330                 335     


Glu Gly Ser Ala Ala Pro Leu Pro Leu Tyr Thr Ser Pro Ser Leu Pro 
            340                 345                 350         


Asn Ile Thr Leu Gly Leu Pro Ala Thr Gly Pro Ser Ala Gly Thr Ala 
        355                 360                 365             


Gly Gln Gln Asp Ala Glu Arg Leu Thr Leu Pro Ala Leu Gln Gln Arg 
    370                 375                 380                 


Leu Ser Leu Phe Pro Gly Thr His Leu Thr Pro Tyr Leu Ser Thr Ser 
385                 390                 395                 400 


Pro Leu Glu Arg Asp Gly Gly Ala Ala His Ser Pro Leu Leu Gln His 
                405                 410                 415     


Met Val Leu Leu Glu Gln Pro Pro Ala Gln Ala Pro Leu Val Thr Asp 
            420                 425                 430         


Trp Tyr Leu Ser Gly Leu Gly Ala Leu Pro Leu His Ala Gln Ser Leu 
        435                 440                 445             


Val Gly Ala Asp Arg Val Ser Pro Ser Ile His Lys Leu Arg Gln His 
    450                 455                 460                 


Arg Pro Leu Gly Arg Thr Gln Ser Ala Pro Leu Pro Gln Asn Ala Gln 
465                 470                 475                 480 


Ala Leu Gln His Leu Val Ile Gln Gln Gln His Gln Gln Phe Leu Glu 
                485                 490                 495     


Lys His Lys Gln Gln Phe Gln Gln Gln Gln Leu Gln Met Asn Lys Ile 
            500                 505                 510         


Ile Pro Lys Pro Ser Glu Pro Ala Arg Gln Pro Glu Ser His Pro Glu 
        515                 520                 525             


Glu Thr Glu Glu Glu Leu Arg Glu His Gln Ala Leu Leu Asp Glu Pro 
    530                 535                 540                 


Tyr Leu Asp Arg Leu Pro Gly Gln Lys Glu Ala His Ala Gln Ala Gly 
545                 550                 555                 560 


Val Gln Val Lys Gln Glu Pro Ile Glu Ser Asp Glu Glu Glu Ala Glu 
                565                 570                 575     


Pro Pro Arg Glu Val Glu Pro Gly Gln Arg Gln Pro Ser Glu Gln Glu 
            580                 585                 590         


Leu Leu Phe Arg Gln Gln Ala Leu Leu Leu Glu Gln Gln Arg Ile His 
        595                 600                 605             


Gln Leu Arg Asn Tyr Gln Ala Ser Met Glu Ala Ala Gly Ile Pro Val 
    610                 615                 620                 


Ser Phe Gly Gly His Arg Pro Leu Ser Arg Ala Gln Ser Ser Pro Ala 
625                 630                 635                 640 


Ser Ala Thr Phe Pro Val Ser Val Gln Glu Pro Pro Thr Lys Pro Arg 
                645                 650                 655     


Phe Thr Thr Gly Leu Val Tyr Asp Thr Leu Met Leu Lys His Gln Cys 
            660                 665                 670         


Thr Cys Gly Ser Ser Ser Ser His Pro Glu His Ala Gly Arg Ile Gln 
        675                 680                 685             


Ser Ile Trp Ser Arg Leu Gln Glu Thr Gly Leu Arg Gly Lys Cys Glu 
    690                 695                 700                 


Cys Ile Arg Gly Arg Lys Ala Thr Leu Glu Glu Leu Gln Thr Val His 
705                 710                 715                 720 


Ser Glu Ala His Thr Leu Leu Tyr Gly Thr Asn Pro Leu Asn Arg Gln 
                725                 730                 735     


Lys Leu Asp Ser Lys Lys Leu Leu Gly Ser Leu Ala Ser Val Phe Val 
            740                 745                 750         


Arg Leu Pro Cys Gly Gly Val Gly Val Asp Ser Asp Thr Ile Trp Asn 
        755                 760                 765             


Glu Val His Ser Ala Gly Ala Ala Arg Leu Ala Val Gly Cys Val Val 
    770                 775                 780                 


Glu Leu Val Phe Lys Val Ala Thr Gly Glu Leu Lys Asn Gly Phe Ala 
785                 790                 795                 800 


Val Val Arg Pro Pro Gly His His Ala Glu Glu Ser Thr Pro Met Gly 
                805                 810                 815     


Phe Cys Tyr Phe Asn Ser Val Ala Val Ala Ala Lys Leu Leu Gln Gln 
            820                 825                 830         


Arg Leu Ser Val Ser Lys Ile Leu Ile Val Asp Trp Asp Val His His 
        835                 840                 845             


Gly Asn Gly Thr Gln Gln Ala Phe Tyr Ser Asp Pro Ser Val Leu Tyr 
    850                 855                 860                 


Met Ser Leu His Arg Tyr Asp Asp Gly Asn Phe Phe Pro Gly Ser Gly 
865                 870                 875                 880 


Ala Pro Asp Glu Val Gly Thr Gly Pro Gly Val Gly Phe Asn Val Asn 
                885                 890                 895     


Met Ala Phe Thr Gly Gly Leu Asp Pro Pro Met Gly Asp Ala Glu Tyr 
            900                 905                 910         


Leu Ala Ala Phe Arg Thr Val Val Met Pro Ile Ala Ser Glu Phe Ala 
        915                 920                 925             


Pro Asp Val Val Leu Val Ser Ser Gly Phe Asp Ala Val Glu Gly His 
    930                 935                 940                 


Pro Thr Pro Leu Gly Gly Tyr Asn Leu Ser Ala Arg Cys Phe Gly Tyr 
945                 950                 955                 960 


Leu Thr Lys Gln Leu Met Gly Leu Ala Gly Gly Arg Ile Val Leu Ala 
                965                 970                 975     


Leu Glu Gly Gly His Asp Leu Thr Ala Ile Cys Asp Ala Ser Glu Ala 
            980                 985                 990         


Cys Val Ser Ala Leu Leu Gly Asn  Glu Leu Asp Pro Leu  Pro Glu Lys 
        995                 1000                 1005             


Val Leu  Gln Gln Arg Pro Asn  Ala Asn Ala Val Arg  Ser Met Glu 
    1010                 1015                 1020             


Lys Val  Met Glu Ile His Ser  Lys Tyr Trp Arg Cys  Leu Gln Arg 
    1025                 1030                 1035             


Thr Thr  Ser Thr Ala Gly Arg  Ser Leu Ile Glu Ala  Gln Thr Cys 
    1040                 1045                 1050             


Glu Asn  Glu Glu Ala Glu Thr  Val Thr Ala Met Ala  Ser Leu Ser 
    1055                 1060                 1065             


Val Gly  Val Lys Pro Ala Glu  Lys Arg Pro Asp Glu  Glu Pro Met 
    1070                 1075                 1080             


Glu Glu  Glu Pro Pro Leu 
    1085                 


<210>  405
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  405

Met Val Gly Tyr Asp Pro Lys Pro Asp Gly Arg Asn Asn Thr Lys Phe 
1               5                   10                  15      


Gln Val Ala Val Ala Gly Ser Val Ser Gly Leu Val Thr Arg Ala Leu 
            20                  25                  30          


Ile Ser Pro Phe Asp Val Ile Lys Ile Arg Phe Gln Leu Gln His Glu 
        35                  40                  45              


Arg Leu Ser Arg Ser Asp Pro Ser Ala Lys Tyr His Gly Ile Leu Gln 
    50                  55                  60                  


Ala Ser Arg Gln Ile Leu Gln Glu Glu Gly Pro Thr Ala Phe Trp Lys 
65                  70                  75                  80  


Gly His Val Pro Ala Gln Ile Leu Ser Ile Gly Tyr Gly Ala Val Gln 
                85                  90                  95      


Phe Leu Ser Phe Glu Met Leu Thr Glu Leu Val His Arg Gly Ser Val 
            100                 105                 110         


Tyr Asp Ala Arg Glu Phe Ser Val His Phe Val Cys Gly Gly Leu Ala 
        115                 120                 125             


Ala Cys Met Ala Thr Leu Thr Val His Pro Val Asp Val Leu Arg Thr 
    130                 135                 140                 


Arg Phe Ala Ala Gln Gly Glu Pro Lys Val Tyr Asn Thr Leu Arg His 
145                 150                 155                 160 


Ala Val Gly Thr Met Tyr Arg Ser Glu Gly Pro Gln Val Phe Tyr Lys 
                165                 170                 175     


Gly Leu Ala Pro Thr Leu Ile Ala Ile Phe Pro Tyr Ala Gly Leu Gln 
            180                 185                 190         


Phe Ser Cys Tyr Ser Ser Leu Lys His Leu Tyr Lys Trp Ala Ile Pro 
        195                 200                 205             


Ala Glu Gly Lys Lys Asn Glu Asn Leu Gln Asn Leu Leu Cys Gly Ser 
    210                 215                 220                 


Gly Ala Gly Val Ile Ser Lys Thr Leu Thr Tyr Pro Leu Asp Leu Phe 
225                 230                 235                 240 


Lys Lys Arg Leu Gln Val Gly Gly Phe Glu His Ala Arg Ala Ala Phe 
                245                 250                 255     


Gly Gln Val Arg Arg Tyr Lys Gly Leu Met Asp Cys Ala Lys Gln Val 
            260                 265                 270         


Leu Gln Lys Glu Gly Ala Leu Gly Phe Phe Lys Gly Leu Ser Pro Ser 
        275                 280                 285             


Leu Leu Lys Ala Ala Leu Ser Thr Gly Phe Met Phe Phe Ser Tyr Glu 
    290                 295                 300                 


Phe Phe Cys Asn Val Phe His Cys Met Asn Arg Thr Ala Ser Gln Arg 
305                 310                 315                 320 


<210>  406
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  406

Met Val Gly Tyr Asp Pro Lys Pro Asp Gly Arg Asn Asn Thr Lys Phe 
1               5                   10                  15      


Gln Val Ala Val Ala Gly Ser Val Ser Gly Leu Val Thr Arg Ala Leu 
            20                  25                  30          


Ile Ser Pro Phe Asp Val Ile Lys Ile Arg Phe Gln Leu Gln His Glu 
        35                  40                  45              


Arg Leu Ser Arg Ser Asp Pro Ser Ala Lys Tyr His Gly Ile Leu Gln 
    50                  55                  60                  


Ala Ser Arg Gln Ile Leu Gln Glu Glu Gly Pro Thr Ala Phe Trp Lys 
65                  70                  75                  80  


Gly His Val Pro Ala Gln Ile Leu Ser Ile Gly Tyr Gly Ala Val Gln 
                85                  90                  95      


Val Tyr Asn Thr Leu Arg His Ala Val Gly Thr Met Tyr Arg Ser Glu 
            100                 105                 110         


Gly Pro Gln Val Phe Tyr Lys Gly Leu Ala Pro Thr Leu Ile Ala Ile 
        115                 120                 125             


Phe Pro Tyr Ala Gly Leu Gln Phe Ser Cys Tyr Ser Ser Leu Lys His 
    130                 135                 140                 


Leu Tyr Lys Trp Ala Ile Pro Ala Glu Gly Lys Lys Asn Glu Asn Leu 
145                 150                 155                 160 


Gln Asn Leu Leu Cys Gly Ser Gly Ala Gly Val Ile Ser Lys Thr Leu 
                165                 170                 175     


Thr Tyr Pro Leu Asp Leu Phe Lys Lys Arg Leu Gln Val Gly Gly Phe 
            180                 185                 190         


Glu His Ala Arg Ala Ala Phe Gly Gln Val Arg Arg Tyr Lys Gly Leu 
        195                 200                 205             


Met Asp Cys Ala Lys Gln Val Leu Gln Lys Glu Gly Ala Leu Gly Phe 
    210                 215                 220                 


Phe Lys Gly Leu Ser Pro Ser Leu Leu Lys Ala Ala Leu Ser Thr Gly 
225                 230                 235                 240 


Phe Met Phe Phe Ser Tyr Glu Phe Phe Cys Asn Val Phe His Cys Met 
                245                 250                 255     


Asn Arg Thr Ala Ser Gln Arg 
            260             


<210>  407
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  407

Met Val Gly Tyr Asp Pro Lys Pro Asp Gly Arg Asn Asn Thr Lys Phe 
1               5                   10                  15      


Gln Val Ala Val Ala Gly Ser Val Ser Gly Leu Val Thr Arg Ala Leu 
            20                  25                  30          


Ile Ser Pro Phe Asp Val Ile Lys Ile Arg Phe Gln Leu Gln His Glu 
        35                  40                  45              


Arg Leu Ser Arg Ser Asp Pro Ser Ala Lys Tyr His Gly Ile Leu Gln 
    50                  55                  60                  


Ala Ser Arg Gln Ile Leu Gln Glu Glu Gly Pro Thr Ala Phe Trp Lys 
65                  70                  75                  80  


Gly His Val Pro Ala Gln Ile Leu Ser Ile Gly Tyr Gly Ala Val Gln 
                85                  90                  95      


Phe Leu Ser Phe Glu Met Leu Thr Glu Leu Val His Arg Gly Ser Val 
            100                 105                 110         


Tyr Asp Ala Arg Glu Phe Ser Val His Phe Val Cys Gly Gly Leu Ala 
        115                 120                 125             


Ala Cys Met Ala Thr Leu Thr Val His Pro Val Asp Val Leu Arg Thr 
    130                 135                 140                 


Arg Phe Ala Ala Gln Gly Glu Pro Lys 
145                 150             


<210>  408
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  408

Met Val Gly Tyr Asp Pro Lys Pro Asp Gly Arg Asn Asn Thr Lys Phe 
1               5                   10                  15      


Gln Val Ala Val Ala Gly Ser Val Ser Gly Leu Val Thr Arg Ala Leu 
            20                  25                  30          


Ile Ser Pro Phe Asp Val Ile Lys Ile Arg Phe Gln Leu Gln His Glu 
        35                  40                  45              


Arg Leu Ser Arg Ser Asp Pro Ser Ala Lys Tyr His Gly Ile Leu Gln 
    50                  55                  60                  


Ala Ser Arg Gln Ile Leu Gln Glu Glu Gly Pro Thr Ala Phe Trp Lys 
65                  70                  75                  80  


Gly His Val Pro Ala Gln Ile Leu Ser Ile Gly Tyr Gly Ala Val Gln 
                85                  90                  95      


Phe Leu Ser Phe Glu Met Leu Thr Glu Leu 
            100                 105     


<210>  409
<211>  67
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  409

Xaa Lys Phe Gln Val Ala Val Ala Gly Ser Val Ser Gly Leu Val Thr 
1               5                   10                  15      


Arg Ala Leu Ile Ser Pro Phe Asp Val Ile Lys Ile Arg Phe Gln Leu 
            20                  25                  30          


Gln His Glu Arg Leu Ser Arg Ser Asp Pro Ser Ala Lys Tyr His Gly 
        35                  40                  45              


Ile Leu Gln Gly Ser Pro His Glu Arg Ile Arg Gly Asn Ala Gly Arg 
    50                  55                  60                  


Gly Leu Trp 
65          


<210>  410
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  410

Met Val Gly Tyr Asp Pro Lys Pro Asp Gly Arg Asn Asn Thr Lys Phe 
1               5                   10                  15      


Gln Val Ala Val Ala Gly Ser Val Ser Gly Leu Val Thr Arg Ala Leu 
            20                  25                  30          


Ile Ser Pro Phe Asp Val Ile Lys Ile Arg Phe Gln Leu Gln His Glu 
        35                  40                  45              


Arg Leu Ser Arg Ser Asp Pro Ser Ala Lys Tyr His Gly Ile Leu Gln 
    50                  55                  60                  


Ala Ser Arg Gln Ile Leu Gln Glu Glu Gly Pro Thr Ala Phe Trp Lys 
65                  70                  75                  80  


Gly His Val Pro Ala 
                85  


<210>  411
<211>  84
<212>  PRT
<213>  Homo sapiens

<400>  411

Met Leu Thr Glu Leu Val His Arg Gly Ser Val Tyr Asp Ala Arg Glu 
1               5                   10                  15      


Phe Ser Val His Phe Val Cys Gly Gly Leu Ala Ala Cys Met Ala Thr 
            20                  25                  30          


Leu Thr Val His Pro Val Asp Val Leu Arg Thr Arg Phe Ala Ala Gln 
        35                  40                  45              


Gly Glu Pro Lys Val Tyr Asn Thr Leu Arg His Ala Val Gly Thr Met 
    50                  55                  60                  


Tyr Arg Ser Glu Gly Pro Gln Val Phe Tyr Lys Gly Leu Ala Pro Thr 
65                  70                  75                  80  


Leu Ile Ala Ile 
                


<210>  412
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  412

Met Val Gly Tyr Asp Pro Lys Pro Asp Gly Arg Asn Asn Thr Lys Phe 
1               5                   10                  15      


Gln Val Ala Val Ala Gly Ser Val Ser Gly Leu Val Thr Arg Ala Leu 
            20                  25                  30          


Ile Ser Pro Phe Asp Val Ile 
        35                  


<210>  413
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  413

Met Val Gly Tyr Asp Pro Lys Pro Asp Gly Arg Asn Asn Thr Lys Phe 
1               5                   10                  15      


Gln Val Ala Val Ala Gly Ser Val Ser Gly Leu Val Thr Arg Ala Leu 
            20                  25                  30          


Ile Ser Pro Phe Asp Val Ile Lys Ile Arg Phe Gln Leu Gln His Glu 
        35                  40                  45              


Arg Leu Ser Arg Ser Asp Pro Ser Ala Lys Tyr His Gly Ile Leu Gln 
    50                  55                  60                  


Ala Ser Arg Gln Ile Leu Gln Glu Glu Gly Pro Thr Ala Phe Trp Lys 
65                  70                  75                  80  


Gly His Val Pro Ala Gln Ile Leu Ser Ile Gly Tyr Gly Ala Val Gln 
                85                  90                  95      


Phe Leu Ser Phe Glu Met Leu Thr Glu Leu Val His Arg Gly Ser Val 
            100                 105                 110         


Tyr Asp Ala Arg Glu Phe Ser Val His Phe Val Cys Gly Gly Leu Ala 
        115                 120                 125             


Ala Cys Met Ala Thr Leu Thr Val His Pro Val Asp Val Leu Arg Thr 
    130                 135                 140                 


Arg Phe Ala Ala Gln Gly Glu Pro Lys Val Arg Arg Tyr Lys Gly Leu 
145                 150                 155                 160 


Met Asp Cys Ala Lys Gln Val Leu Gln Lys Glu Gly Ala Leu Gly Phe 
                165                 170                 175     


Phe Lys Gly Leu Ser Pro 
            180         


<210>  414
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  414

Met Val Gly Tyr Asp Pro Lys Pro Asp Gly Arg Asn Asn Thr Lys Phe 
1               5                   10                  15      


Gln Val Ala Val Ala Gly Ser Val Ser Gly Leu Val Thr Arg Ala Leu 
            20                  25                  30          


Ile Ser Pro Phe Asp Val Ile Lys Ile Arg Phe Gln Leu Gln His Glu 
        35                  40                  45              


Arg Leu Ser Arg Ser Asp Pro Ser Ala Lys Tyr His Gly Ile Leu Gln 
    50                  55                  60                  


Ala Ser Arg Gln Ile Leu Gln Glu Glu Gly Pro Thr Ala Phe Trp Lys 
65                  70                  75                  80  


Gly His Val Pro Ala Gln Ile Leu Ser Ile Gly Tyr Gly Ala Val Gln 
                85                  90                  95      


Phe Leu Ser Phe Glu Met Leu Thr Glu Leu Val His Arg Gly Ser Val 
            100                 105                 110         


Tyr Asp Ala Arg Glu Phe Ser Val His Phe Val Cys Gly Gly Leu Ala 
        115                 120                 125             


Ala Cys Met Ala Thr Leu Thr Val His Pro Val Asp Val Leu Arg Thr 
    130                 135                 140                 


Arg Phe Ala Ala Gln Gly Glu 
145                 150     


