
                                SEQUENCE LISTING

<110> Sana Biotechnology, Inc.

<120> SAFETY SWITCHES FOR REGULATION OF GENE
  EXPRESSION

<130> 122864-01-5012-WO

<150> 62/962,730          
<151> 2020-01-17  

<150> 62/962,739          
<151> 2020-01-17  

<150> 62/962,764          
<151> 2020-01-17  

<160> 110

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<220> 
<221> REPEAT         
<222> (1)...(4)
<223> n is 1-10

<400> 1
Gly Gly Gly Ser
 1              


<210> 2
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<220> 
<221> REPEAT         
<222> (1)...(8)
<223> n is 1-10

<400> 2
Gly Gly Gly Ser Gly Gly Gly Ser
 1               5              


<210> 3
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<220> 
<221> REPEAT         
<222> (1)...(3)
<223> n is 1-10

<400> 3
Gly Ser Gly
 1          


<210> 4
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> T2A self-cleaving peptide sequence

<400> 4
Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu
 1               5                  10                  15      
Glu Asn Pro Gly Pro
            20      


<210> 5
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> P2A self-cleaving peptide sequence

<400> 5
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val
 1               5                  10                  15      
Glu Glu Asn Pro Gly Pro
            20          


<210> 6
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> E2A self-cleaving peptide sequence

<400> 6
Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp
 1               5                  10                  15      
Val Glu Ser Asn Pro Gly Pro
            20              


<210> 7
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> F2A self-cleaving peptide sequence

<400> 7
Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala
 1               5                  10                  15      
Gly Asp Val Glu Ser Asn Pro Gly Pro
            20                  25  


<210> 8
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker RH_1

<400> 8
Glu Ala Ala Ala Lys
 1               5  


<210> 9
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker RH_2

<400> 9
Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys
 1               5                  10  


<210> 10
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker RH_3

<400> 10
Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys
 1               5                  10                  15  


<210> 11
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker RH_5

<400> 11
Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys
 1               5                  10                  15      
Ala
    


<210> 12
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker RH_6

<400> 12
Ala Glu Ala Ala Ala Lys Ala Glu Ala Ala Ala Lys Ala Glu Ala Ala
 1               5                  10                  15      
Ala Lys Ala Glu Ala Ala Ala Lys
            20                  


<210> 13
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker RH_7

<400> 13
Ala Glu Ala Ala Ala Lys Ala Glu Ala Ala Ala Lys Ala Glu Ala Ala
 1               5                  10                  15      
Ala Lys Ala Glu Ala Ala Ala Lys Ala Glu Ala Ala Ala Lys
            20                  25                  30  


<210> 14
<211> 46
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker RH_8

<400> 14
Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys
 1               5                  10                  15      
Glu Ala Ala Ala Lys Ala Leu Glu Ala Glu Ala Ala Ala Lys Glu Ala
            20                  25                  30          
Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala
        35                  40                  45      


<210> 15
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker REPR_15

<400> 15
Pro Ala Pro Ala Pro
 1               5  


<210> 16
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker REPR_2

<400> 16
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
 1               5                  10  


<210> 17
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker REPR_5

<400> 17
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
 1               5                  10                  15      


<210> 18
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker REPR_8

<400> 18
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
 1               5                  10                  15      
Ala Pro Ala Pro Ala Pro
            20          


<210> 19
<211> 28
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker REPR_11

<400> 19
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
 1               5                  10                  15      
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
            20                  25              


<210> 20
<211> 34
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker REPR_14

<400> 20
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
 1               5                  10                  15      
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
            20                  25                  30          
Ala Pro
        


<210> 21
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker FGSR_15

<400> 21
Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser
 1               5                  10                  15      
Leu Asp
        


<210> 22
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker FGSR_16

<400> 22
Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr
 1               5                  10                  


<210> 23
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker FGSR_18

<400> 23
Asn Ser Gly Ala Gly Gly Ser Gly Gly Ser Ser Gly Ser Asp Gly Ala
 1               5                  10                  15      
Ser Gly Ser Arg Asp
            20      


<210> 24
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker FGSR_1

<400> 24
Gly Gly Gly Gly Ser
 1               5  


<210> 25
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker FGSR_10

<400> 25
Gly Gly Gly Ser
 1              


<210> 26
<211> 2
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker FGSR_14

<400> 26
Gly Ser
 1      


<210> 27
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker FGSR_17

<400> 27
Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe
 1               5                  10          


<210> 28
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker FGSR_2

<400> 28
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10  


<210> 29
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker FGSR_3

<400> 29
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15  


<210> 30
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker FGSR_4

<400> 30
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
 1               5                  10                  15      
Gly Gly Gly Ser
            20  


<210> 31
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker FGSR_5

<400> 31
Gly Gly Ser
 1          


<210> 32
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker FGSR_6

<400> 32
Gly Gly Gly Gly Gly Gly
 1               5      


<210> 33
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker FGSR_7

<400> 33
Gly Gly Gly Gly Gly Gly Gly Gly
 1               5              


<210> 34
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker AP_5

<400> 34
Ser Ser Ser Ser Gly
 1               5  


<210> 35
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker AP_6

<400> 35
Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly
 1               5                  10  


<210> 36
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker AP_7

<400> 36
Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly
 1               5                  10                  15  


<210> 37
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker AP_8
      

<400> 37
Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser
 1               5                  10                  15      
Ser Ser Ser Gly
            20  


<210> 38
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker AP_9
      

<400> 38
Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser
 1               5                  10                  15      
Ser Ser Ser Gly Ser Ser Ser Ser Gly
            20                  25  


<210> 39
<211> 62
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker AP_18
      

<400> 39
Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe
 1               5                  10                  15      
Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro
            20                  25                  30          
Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser
        35                  40                  45              
Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp
    50                  55                  60          


<210> 40
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker NP_35

<400> 40
Thr Val Ala Ala Pro
 1               5  


<210> 41
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker NP_36

<400> 41
Ala Ser Thr Lys Gly Pro
 1               5      


<210> 42
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker NP_37

<400> 42
Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro
 1               5                  10              


<210> 43
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker NP_38

<400> 43
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro
 1               5                  10          


<210> 44
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker NP_39

<400> 44
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
 1               5                  10              


<210> 45
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker NP_1

<400> 45
Ala Gln Gly Thr Leu Ser Pro Ala Asp Lys Thr Asn Val Lys Ala Ala
 1               5                  10                  15      
Trp Gly Lys Val Met Thr
            20          


<210> 46
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker NP_21

<400> 46
Pro Gly Asn Pro Thr Thr Thr Val Val Pro Pro Ala Ser Thr Ser Thr
 1               5                  10                  15      
Ser Arg Pro Thr Ser Ser Thr Ser Ser Pro Val Ser Thr Pro Thr Gly
            20                  25                  30          
Gln Pro Gly Gly
        35      


<210> 47
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 1EI1A

<400> 47
Gly Gly Lys Phe Asp Asp Asn Ser Tyr Lys Val Ser Gly Gly Leu His
 1               5                  10                  15      
Gly Val Gly
            


<210> 48
<211> 44
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 1KQFA

<400> 48
Gly Arg Leu Phe Ala Ile Asn Lys Met Ala Glu Gly Pro Phe Pro Glu
 1               5                  10                  15      
His Tyr Glu Pro Ile Glu Thr Pro Leu Gly Thr Asn Pro Leu His Pro
            20                  25                  30          
Asn Val Val Ser Asn Pro Val Val Arg Leu Tyr Glu
        35                  40                  


<210> 49
<211> 51
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 1B8TA

<400> 49
Tyr Gly Pro Lys Gly Lys Gly Lys Gly Met Gly Ala Gly Thr Leu Ser
 1               5                  10                  15      
Thr Asp Lys Gly Glu Ser Leu Gly Ile Lys Tyr Glu Glu Gly Gln Ser
            20                  25                  30          
His Arg Pro Thr Asn Pro Asn Ala Ser Arg Met Ala Gln Lys Val Gly
        35                  40                  45              
Gly Ser Asp
    50      


<210> 50
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker JP1

<400> 50
Gly Lys Gly Lys Gly
 1               5  


<210> 51
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker JP2

<400> 51
Gly Lys Gly Lys Gly Met Gly Ala Gly
 1               5                  


<210> 52
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker JP3

<400> 52
Gly Lys Gly Lys Gly Met Gly Ala Gly Thr Leu Ser Thr Asp Lys Gly
 1               5                  10                  15      


<210> 53
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker JP4

<400> 53
Gly Lys Gly Lys Gly Met Gly Ala Gly Thr Leu Ser Thr Asp Lys Gly
 1               5                  10                  15      
Glu Ser Leu Gly
            20  


<210> 54
<211> 85
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 2ZT5A

<400> 54
Lys Pro Leu Lys Glu Pro Lys Thr Val Asn Val Val Gln Phe Glu Pro
 1               5                  10                  15      
Ser Lys Gly Ala Ile Gly Lys Ala Tyr Lys Lys Asp Ala Lys Leu Val
            20                  25                  30          
Met Glu Tyr Leu Ala Ile Cys Asp Glu Cys Tyr Ile Thr Glu Met Glu
        35                  40                  45              
Met Leu Leu Asn Glu Lys Gly Glu Phe Thr Ile Glu Thr Glu Gly Lys
    50                  55                  60                  
Thr Phe Gln Leu Thr Lys Asp Met Ile Asn Val Lys Arg Phe Gln Lys
65                  70                  75                  80  
Thr Leu Tyr Val Glu
                85  


<210> 55
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker LP1

<400> 55
Ile Glu Gly Arg Met Asp
 1               5      


<210> 56
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker pVT197

<400> 56
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala
 1               5                  10                  15      
Ala Gln Pro Ala
            20  


<210> 57
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker pVT311

<400> 57
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala
 1               5                  10                  15      
Ala Gln Pro Ala Ser
            20      


<210> 58
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker LP1

<400> 58
Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15      


<210> 59
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker LP2

<400> 59
Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly
 1               5                  10                  15  


<210> 60
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker LP3

<400> 60
Gly Gly Ser Gly Gly His Met Gly Ser Gly Gly
 1               5                  10      


<210> 61
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker LP4

<400> 61
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly
 1               5                  10      


<210> 62
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker LP5

<400> 62
Gly Gly Ser Gly Gly
 1               5  


<210> 63
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker LP6

<400> 63
Gly Gly Ser Gly Gly Gly Gly Gly
 1               5              


<210> 64
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker LP7

<400> 64
Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly
 1               5                  10                  15      
Gly Gly
        


<210> 65
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker LP8

<400> 65
Gly Ser Gly Gly Gly Thr Gly Gly Gly Ser Gly
 1               5                  10      


<210> 66
<211> 2
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker LP9

<400> 66
Gly Thr
 1      


<210> 67
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker LP10

<400> 67
Gly Ser Gly Ser Gly Ser
 1               5      


<210> 68
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker LP11

<400> 68
Gly Ser Gly Ser Gly Ser Gly Ser
 1               5              


<210> 69
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker LP12

<400> 69
Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser
 1               5                  10  


<210> 70
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker LP13

<400> 70
Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser
 1               5                  10          


<210> 71
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker LP14

<400> 71
Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser
 1               5                  10                  


<210> 72
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker LP15

<400> 72
Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser
 1               5                  10                  15      


<210> 73
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker LP16

<400> 73
Ser Gly Gly Ser Gly Gly Ser Ser His Ser
 1               5                  10  


<210> 74
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker LP17

<400> 74
Ala Ala Gly Ala Ala Thr Ala Ala
 1               5              


<210> 75
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker LP18

<400> 75
Glu Pro Lys Ser Ala Asp Lys Thr His Thr Ala Pro Pro Ala Pro
 1               5                  10                  15  


<210> 76
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker JP5

<400> 76
Glu Pro Lys Ser Asp Lys Thr His Thr Pro Pro Pro
 1               5                  10          


<210> 77
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker JP6

<400> 77
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15  


<210> 78
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker JP7

<400> 78
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
 1               5                  10                  15      
Pro Glu Leu Leu Gly Gly Pro
            20              


<210> 79
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker JP8

<400> 79
Glu Pro Lys Ser Asp Lys Thr His Thr Pro Pro Pro Ala Pro Glu Leu
 1               5                  10                  15      
Leu Gly Gly Pro
            20  


<210> 80
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker JP9

<400> 80
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
 1               5                  10                  15      
Pro Glu Gly Gly Pro
            20      


<210> 81
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker JP10

<400> 81
Glu Pro Lys Ser Asp Lys Thr His Thr Pro Pro Pro Ala Pro Glu Gly
 1               5                  10                  15      
Gly Pro
        


<210> 82
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker JP11

<400> 82
Glu Arg Lys Val Glu Pro Pro Pro
 1               5              


<210> 83
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker JP12

<400> 83
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro
 1               5                  10          


<210> 84
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker JP13

<400> 84
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val
 1               5                  10                  15      
Ala Gly Pro
            


<210> 85
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker JP14

<400> 85
Glu Arg Lys Val Glu Pro Pro Pro Ala Pro Pro Val Ala Gly Pro
 1               5                  10                  15  


<210> 86
<211> 59
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker JP15

<400> 86
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys
 1               5                  10                  15      
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro
            20                  25                  30          
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu
        35                  40                  45              
Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro
    50                  55                  


<210> 87
<211> 49
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker JP16

<400> 87
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Pro Arg Pro Glu
 1               5                  10                  15      
Pro Lys Ser Asp Thr Pro Pro Pro Pro Arg Pro Glu Pro Lys Ser Asp
            20                  25                  30          
Thr Pro Pro Pro Pro Arg Pro Glu Pro Lys Ser Asp Thr Pro Pro Pro
        35                  40                  45              
Pro
    


<210> 88
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker NP_8

<400> 88
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr
 1               5                  10          


<210> 89
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker JP17

<400> 89
Glu Ser Lys Tyr Gly Pro Pro Pro Ser Pro
 1               5                  10  


<210> 90
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker JP18

<400> 90
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro
 1               5                  10          


<210> 91
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker JP19

<400> 91
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe
 1               5                  10                  15      
Leu Gly Gly Pro
            20  


<210> 92
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker JP20

<400> 92
Glu Ser Lys Tyr Gly Pro Pro Pro Ser Pro Ala Pro Glu Phe Leu Gly
 1               5                  10                  15      
Gly Pro
        


<210> 93
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker JP21

<400> 93
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Gly
 1               5                  10                  15      
Gly Pro
        


<210> 94
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker JP22

<400> 94
Glu Ser Lys Tyr Gly Pro Pro Pro Ser Pro Ala Pro Glu Gly Gly Pro
 1               5                  10                  15      


<210> 95
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker JP23

<400> 95
Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Gly
 1               5                  10                  15      
Gly Ser Gly Gly Ser
            20      


<210> 96
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker JP24

<400> 96
Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
 1               5                  10                  15      


<210> 97
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker JP25

<400> 97
Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
 1               5                  10      


<210> 98
<211> 966
<212> DNA
<213> Artificial Sequence

<220> 
<223> Promoter EF1A

<400> 98
ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg 60
ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt 120
gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca 180
gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggtaagtgcc 240
gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt gccttgaatt 300
acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg aagtgggtgg 360
gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt tgaggcctgg 420
cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg tctcgctgct 480
ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct ttttttctgg 540
caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt ttttggggcc 600
gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg gggcctgcga 660
gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc tctggtgcct 720
ggtctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg gtcggcacca 780
gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc aaaatggagg 840
acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag ggcctttccg 900
tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag gcacctcgat 960
tagttc                                                            966

<210> 99
<211> 1177
<212> DNA
<213> Artificial Sequence

<220> 
<223> Promoter UBC

<400> 99
ggtgcagcgg cctccgcgcc gggttttggc gcctcccgcg ggcgcccccc tcctcacggc 60
gagcgctgcc acgtcagacg aagggcgcag gagcgttcct gatccttccg cccggacgct 120
caggacagcg gcccgctgct cataagactc ggccttagaa ccccagtatc agcagaagga 180
cattttagga cgggacttgg gtgactctag ggcactggtt ttctttccag agagcggaac 240
aggcgaggaa aagtagtccc ttctcggcga ttctgcggag ggatctccgt ggggcggtga 300
acgccgatga ttatataagg acgcgccggg tgtggcacag ctagttccgt cgcagccggg 360
atttgggtcg cggttcttgt ttgtggatcg ctgtgatcgt cacttggtga gttgcgggct 420
gctgggctgg ccggggcttt cgtggccgcc gggccgctcg gtgggacgga agcgtgtgga 480
gagaccgcca agggctgtag tctgggtccg cgagcaaggt tgccctgaac tgggggttgg 540
ggggagcgca caaaatggcg gctgttcccg agtcttgaat ggaagacgct tgtaaggcgg 600
gctgtgaggt cgttgaaaca aggtgggggg catggtgggc ggcaagaacc caaggtcttg 660
aggccttcgc taatgcggga aagctcttat tcgggtgaga tgggctgggg caccatctgg 720
ggaccctgac gtgaagtttg tcactgactg gagaactcgg gtttgtcgtc tggttgcggg 780
ggcggcagtt atgcggtgcc gttgggcagt gcacccgtac ctttgggagc gcgcgcctcg 840
tcgtgtcgtg acgtcacccg ttctgttggc ttataatgca gggtggggcc acctgccggt 900
aggtgtgcgg taggcttttc tccgtcgcag gacgcagggt tcgggcctag ggtaggctct 960
cctgaatcga caggcgccgg acctctggtg aggggaggga taagtgaggc gtcagtttct 1020
ttggtcggtt ttatgtacct atcttcttaa gtagctgaag ctccggtttt gaactatgcg 1080
ctcggggttg gcgagtgtgt tttgtgaagt tttttaggca ccttttgaaa tgtaatcatt 1140
tgggtcaata tgtaattttc agtgttagac tagtaaa                          1177

<210> 100
<211> 511
<212> DNA
<213> Artificial Sequence

<220> 
<223> Promoter Pgk

<400> 100
ttctaccggg taggggaggc gcttttccca aggcagtctg gagcatgcgc tttagcagcc 60
ccgctgggca cttggcgcta cacaagtggc ctctggcctc gcacacattc cacatccacc 120
ggtaggcgcc aaccggctcc gttctttggt ggccccttcg cgccaccttc tactcctccc 180
ctagtcagga agttcccccc cgccccgcag ctcgcgtcgt gcaggacgtg acaaatggaa 240
gtagcacgtc tcactagtct cgtgcagatg gacagcaccg ctgagcaatg gaagcgggta 300
ggcctttggg gcagcggcca atagcagctt tgctccttcg ctttctgggc tcagaggctg 360
ggaaggggtg ggtccggggg cgggctcagg ggcgggctca ggggcggggc gggcgcccga 420
aggtcctccg gaggcccggc attctgcacg cttcaaaagc gcacgtctgc cgcgctgttc 480
tcctcttcct catctccggg cctttcgacc t                                511

<210> 101
<211> 589
<212> DNA
<213> Artificial Sequence

<220> 
<223> Promoter CMV

<400> 101
tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg 60
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt 120
gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca 180
atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc 240
aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta 300
catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac 360
catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg 420
atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg 480
ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt 540
acggtgggag gtctatataa gcagagctgg tttagtgaac cgtcagatc             589

<210> 102
<211> 1718
<212> DNA
<213> Artificial Sequence

<220> 
<223> Promoter CAGGS

<400> 102
actagttatt aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc 60
cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca 120
ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt 180
caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg 240
ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag 300
tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt 360
accatggtcg aggtgagccc cacgttctgc ttcactctcc ccatctcccc cccctcccca 420
cccccaattt tgtatttatt tattttttaa ttattttgtg cagcgatggg ggcggggggg 480
gggggggggc gcgcgccagg cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg 540
agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa agtttccttt tatggcgagg 600
cggcggcggc ggcggcccta taaaaagcga agcgcgcggc gggcggggag tcgctgcgac 660
gctgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac 720
tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg ggctgtaatt 780
agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc 840
tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg 900
tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg 960
cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc 1020
ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt 1080
gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc cctccccgag 1140
ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg 1200
ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg 1260
ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg 1320
cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt 1380
tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc 1440
gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt 1500
cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct 1560
gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta 1620
gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc 1680
tggttattgt gctgtctcat cattttggca aagaattc                         1718

<210> 103
<211> 344
<212> DNA
<213> Artificial Sequence

<220> 
<223> Promoter SV40

<400> 103
ctgtggaatg tgtgtcagtt agggtgtgga aagtccccag gctccccagc aggcagaagt 60
atgcaaagca tgcatctcaa ttagtcagca accaggtgtg gaaagtcccc aggctcccca 120
gcaggcagaa gtatgcaaag catgcatctc aattagtcag caaccatagt cccgccccta 180
actccgccca tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga 240
ctaatttttt ttatttatgc agaggccgag gccgcctctg cctctgagct attccagaag 300
tagtgaggag gcttttttgg aggcctaggc ttttgcaaaa agct                  344

<210> 104
<211> 283
<212> DNA
<213> Artificial Sequence

<220> 
<223> Promoter COPIA

<400> 104
atctgttgga atatactatt caacctacaa aaataacgtt aaacaacact actttatatt 60
tgatatgaat ggccacacct tttatgccat aaaacatatt gtaagagaat accactcttt 120
ttattccttc tttccttctt gtacgttttt tgctgtgagt aggtcgtggt gctggtgttg 180
cagttgaaat aacttaaaat ataaatcata aaactcaaac ataaacttga ctatttattt 240
atttattaag aaaggaaata taaattataa attacaacag gtt                   283

<210> 105
<211> 307
<212> DNA
<213> Artificial Sequence

<220> 
<223> Promoter ACT5C

<400> 105
ggaagtacac tcttcatggc gatatacaag acacacacaa gcacgaacac ccagttgcgg 60
aggaaattct ccgtaaatga aaacccaatc ggcgaacaat tcatacccat atatggtaaa 120
agttttgaac gcgacttgag agcggagagc attgcggctg ataaggtttt agcgctaagc 180
gggctttata aaacgggctg cgggaccagt tttcatatca ctaccgtttg agttcttgtg 240
ctgtgtggat actcctcccg acacaaagcc gctccatcag ccagcagtcg tctaatccag 300
agacacc                                                           307

<210> 106
<211> 424
<212> DNA
<213> Artificial Sequence

<220> 
<223> Promoter TRE

<400> 106
ggtaccgagc tcgactttca cttttctcta tcactgatag ggagtggtaa actcgacttt 60
cacttttctc tatcactgat agggagtggt aaactcgact ttcacttttc tctatcactg 120
atagggagtg gtaaactcga ctttcacttt tctctatcac tgatagggag tggtaaactc 180
gactttcact tttctctatc actgataggg agtggtaaac tcgactttca cttttctcta 240
tcactgatag ggagtggtaa actcgacttt cacttttctc tatcactgat agggagtggt 300
aaactcgacc tatataagca gagctcgttt agtgaaccgt cagatcgcct ggagacgcca 360
tccacgctgt tttgacctcc atagaagaca ccgggaccga tccagcctcc gcggccccga 420
attg                                                              424

<210> 107
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Cas9 Target site

<400> 107
cgtgagtaaa cctgaatctt tgg                                         23

<210> 108
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD20 fragment

<400> 108
Cys Pro Tyr Ser Asn Pro Ser Leu Cys Ser
 1               5                  10  


<210> 109
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Cas9 Target site

<400> 109
ggggccacta gggacaggat tgg                                         23

<210> 110
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Cas9 Target site

<400> 110
ccagctgtgg ctacaacata ggg                                         23
