                         SEQUENCE LISTING

<110>  Protagonist Therapeutics, Inc.
       Bhandari, Ashok
       Frederick, Brian Troy
       Tran, Tran Trung
       Bourne, Gregory Thomas
 
<120>  PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO 
       TREAT INFLAMMATORY DISEASES

<130>  PRTH-045/01WO 321085-2354

<150>  US 62/961,617
<151>  2020-01-15

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - peptide inhibitor of IL23 receptor


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  penicillamine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  7-Phenyl-Tryptophan

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Penicillamine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  4-(2-aminoethoxy)-L-phenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  L-2-Napthylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Alpha-methyl-L-Lysine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D form Leucine

<400>  1

Xaa Asn Thr Xaa Lys Xaa Xaa Xaa Xaa Lys Asn Leu 
1               5                   10          


<210>  2
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - peptide inhibitor of IL23 receptor


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  penicillamine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  7-thienyl-Tryptophan

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Penicillamine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  4-(2-aminoethoxy)-L-phenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  L-2-Napthylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Alpha-methyl-L-Lysine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D form Lysine

<400>  2

Xaa Asn Thr Xaa Gln Xaa Xaa Xaa Xaa Lys Asn Lys 
1               5                   10          


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - peptide inhibitor of IL23 receptor


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D form Arginine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Abu

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  7-Phenyl-Tryptophan

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  4-(2-aminoethoxy)-L-phenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  L-2-Napthylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  alpha-methyl-L-Lysine

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  D form Leucine

<400>  3

Arg Xaa Gln Thr Xaa Lys Cys Xaa Xaa Xaa Lys Asn Leu 
1               5                   10              


<210>  4
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - peptide inhibitor of IL23 receptor


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D form Arginine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Abu

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  7-Phenyl-Tryptophan

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  4-(2-aminoethoxy)-L-phenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  L-2-Napthylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  alpha-methyl-L-Lysine

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  ACETYLATION

<400>  4

Arg Xaa Gln Thr Xaa Lys Cys Xaa Xaa Xaa Lys Asn 
1               5                   10          


<210>  5
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - peptide inhibitor of IL23 receptor


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D form Arginine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Abu

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  7-Phenyl-Tryptophan

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  4-(2-aminoethoxy)-L-phenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  L-2-Napthylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  alpha-methyl-L-Lysine

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  D form Lysine

<400>  5

Arg Xaa Gln Thr Xaa Lys Cys Xaa Xaa Xaa Lys Asn Lys 
1               5                   10              


<210>  6
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - peptide inhibitor of IL23 receptor


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Penicillamine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  6-Phenyl-Tryptophan

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Penicillamine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  4-(2-aminoethoxy)-L-phenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  L-2-Napthylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Alpha-methyl-L-Lysine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D form Lysine

<400>  6

Xaa Asn Thr Xaa Gln Xaa Xaa Xaa Xaa Lys Asn Lys 
1               5                   10          


<210>  7
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - peptide inhibitor of IL23 receptor


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Penicillamine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  7-(3-methylphenyl)-Tryptophan

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Penicillamine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  4-(2-aminoethoxy)-L-phenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  L-2-Napthylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Alpha-methyl-L-Lysine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D form Lysine

<400>  7

Xaa Asn Thr Xaa Gln Xaa Xaa Xaa Xaa Lys Asn Lys 
1               5                   10          


<210>  8
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - peptide inhibitor of IL23 receptor


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Penicillamine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  7-(3-MethoxyPhenyl)-Tryptophan

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Penicillamine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  4-(2-aminoethoxy)-L-phenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  L-2-Napthylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Alpha-methyl-L-Lysine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D form Lysine

<400>  8

Xaa Asn Thr Xaa Gln Xaa Xaa Xaa Xaa Lys Asn Lys 
1               5                   10          


<210>  9
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - peptide inhibitor of IL23 receptor


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Penicillamine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  7-(3-trifluoromethylphenyl)-Tryptophan

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Penicillamine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  4-(2-aminoethoxy)-L-phenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  L-2-Napthylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Alpha-methyl-L-Lysine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D form Lysine

<400>  9

Xaa Asn Thr Xaa Gln Xaa Xaa Xaa Xaa Lys Asn Lys 
1               5                   10          


<210>  10
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - peptide inhibitor of IL23 receptor


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Penicillamine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  7-(4-Fluoro-phenyl)Tryptophan

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Penicillamine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  4-(2-aminoethoxy)-L-phenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  L-2-Napthylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Alpha-methyl-L-Lysine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D form Lysine

<400>  10

Xaa Asn Thr Xaa Gln Xaa Xaa Xaa Xaa Lys Asn Lys 
1               5                   10          


<210>  11
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - peptide inhibitor of IL23 receptor


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Penicillamine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  7-(3-isopropylphenyl)-Tryptophan

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Penicillamine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  4-(2-aminoethoxy)-L-phenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  L-2-Napthylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Alpha-methyl-L-Lysine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D form Lysine

<400>  11

Xaa Asn Thr Xaa Gln Xaa Xaa Xaa Xaa Lys Asn Lys 
1               5                   10          


<210>  12
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - peptide inhibitor of IL23 receptor


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Penicillamine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  7-(3-trifluoromethoxyphenyl)-Tryptophan

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Penicillamine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  4-(2-aminoethoxy)-L-phenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  L-2-Napthylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Alpha-methyl-L-Lysine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D form Lysine

<400>  12

Xaa Asn Thr Xaa Gln Xaa Xaa Xaa Xaa Lys Asn Lys 
1               5                   10          


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - peptide inhibitor of IL23 receptor


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  penicillamine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  7-Phenyl-Tryptophan

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Penicillamine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  4-(2-aminoethoxy)-L-phenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  3-Quin

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  4-amino-4-carboxy-tetrahydropyran

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D form Lysine

<400>  13

Xaa Asn Thr Xaa Lys Xaa Xaa Xaa Xaa Glu Asn Lys 
1               5                   10          


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - peptide inhibitor of IL23 receptor


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  penicillamine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  7-Phenyl-Tryptophan

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Penicillamine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  4-(2-aminoethoxy)-L-phenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  3-Quin

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Alpha-methyl-L-Lysine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D form Lysine

<400>  14

Xaa Asn Thr Xaa Lys Xaa Xaa Xaa Xaa Lys Asn Lys 
1               5                   10          


<210>  15
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - peptide inhibitor of IL23 receptor


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  penicillamine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  7-Phenyl-Tryptophan

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Penicillamine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  4-(2-aminoethoxy)-L-phenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  3-Quin

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  4-amino-4-carboxy-tetrahydropyran

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D form Leucine

<400>  15

Xaa Asn Thr Xaa Lys Xaa Xaa Xaa Xaa Glu Asn Leu 
1               5                   10          


<210>  16
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - peptide inhibitor of IL23 receptor


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  penicillamine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  7-Phenyl-Tryptophan

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Penicillamine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  4-(2-aminoethoxy)-L-phenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  3-Quin

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Alpha-methyl-L-Lysine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D form Leucine

<400>  16

Xaa Asn Thr Xaa Lys Xaa Xaa Xaa Xaa Lys Asn Leu 
1               5                   10          


<210>  17

<400>  17
000

<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - peptide inhibitor of IL23 receptor


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Abu

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  7-Phenyl-Tryptophan

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  4-(2-aminoethoxy)-L-phenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  L-2-Napthylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  alpha-methyl-L-Lysine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D form Leucine

<400>  18

Xaa Gln Thr Xaa Lys Cys Xaa Xaa Xaa Lys Asn Leu 
1               5                   10          


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - peptide inhibitor of IL23 receptor


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Abu

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  7-Phenyl-Tryptophan

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  4-(2-aminoethoxy)-L-phenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  L-2-Napthylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  alpha-methyl-L-Lysine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D form Lysine

<400>  19

Xaa Gln Thr Xaa Lys Cys Xaa Xaa Xaa Lys Asn Lys 
1               5                   10          


<210>  20
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  20

Asn Trp Gln Pro Trp Ser Ser Pro Phe Val His Gln Thr Ser Gln Glu 
1               5                   10                  15      


Thr Gly Lys Arg 
            20  


<210>  21

<400>  21
000

<210>  22

<400>  22
000

