                         SEQUENCE LISTING

<110>  EnClear Therapies, Inc.
 
<120>  SYSTEM AND METHOD OF TREATING NEUROLOGICAL DISORDERS

<130>  120902-10402

<150>  62/960,861
<151>  2020-01-14

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  163
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(163)
<223>  PIN1

<400>  1

Met Ala Asp Glu Glu Lys Leu Pro Pro Gly Trp Glu Lys Arg Met Ser 
1               5                   10                  15      


Arg Ser Ser Gly Arg Val Tyr Tyr Phe Asn His Ile Thr Asn Ala Ser 
            20                  25                  30          


Gln Trp Glu Arg Pro Ser Gly Asn Ser Ser Ser Gly Gly Lys Asn Gly 
        35                  40                  45              


Gln Gly Glu Pro Ala Arg Val Arg Cys Ser His Leu Leu Val Lys His 
    50                  55                  60                  


Ser Gln Ser Arg Arg Pro Ser Ser Trp Arg Gln Glu Lys Ile Thr Arg 
65                  70                  75                  80  


Thr Lys Glu Glu Ala Leu Glu Leu Ile Asn Gly Tyr Ile Gln Lys Ile 
                85                  90                  95      


Lys Ser Gly Glu Glu Asp Phe Glu Ser Leu Ala Ser Gln Phe Ser Asp 
            100                 105                 110         


Cys Ser Ser Ala Lys Ala Arg Gly Asp Leu Gly Ala Phe Ser Arg Gly 
        115                 120                 125             


Gln Met Gln Lys Pro Phe Glu Asp Ala Ser Phe Ala Leu Arg Thr Gly 
    130                 135                 140                 


Glu Met Ser Gly Pro Val Phe Thr Asp Ser Gly Ile His Ile Ile Leu 
145                 150                 155                 160 


Arg Thr Glu 
            


<210>  2
<211>  458
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(458)
<223>  FKBP4

<400>  2

Thr Ala Glu Glu Met Lys Ala Thr Glu Ser Gly Ala Gln Ser Ala Pro 
1               5                   10                  15      


Leu Pro Met Glu Gly Val Asp Ile Ser Pro Lys Gln Asp Glu Gly Val 
            20                  25                  30          


Leu Lys Val Ile Lys Arg Glu Gly Thr Gly Thr Glu Met Pro Met Ile 
        35                  40                  45              


Gly Asp Arg Val Phe Val His Tyr Thr Gly Trp Leu Leu Asp Gly Thr 
    50                  55                  60                  


Lys Phe Asp Ser Ser Leu Asp Arg Lys Asp Lys Phe Ser Phe Asp Leu 
65                  70                  75                  80  


Gly Lys Gly Glu Val Ile Lys Ala Trp Asp Ile Ala Ile Ala Thr Met 
                85                  90                  95      


Lys Val Gly Glu Val Cys His Ile Thr Cys Lys Pro Glu Tyr Ala Tyr 
            100                 105                 110         


Gly Ser Ala Gly Ser Pro Pro Lys Ile Pro Pro Asn Ala Thr Leu Val 
        115                 120                 125             


Phe Glu Val Glu Leu Phe Glu Phe Lys Gly Glu Asp Leu Thr Glu Glu 
    130                 135                 140                 


Glu Asp Gly Gly Ile Ile Arg Arg Ile Gln Thr Arg Gly Glu Gly Tyr 
145                 150                 155                 160 


Ala Lys Pro Asn Glu Gly Ala Ile Val Glu Val Ala Leu Glu Gly Tyr 
                165                 170                 175     


Tyr Lys Asp Lys Leu Phe Asp Gln Arg Glu Leu Arg Phe Glu Ile Gly 
            180                 185                 190         


Glu Gly Glu Asn Leu Asp Leu Pro Tyr Gly Leu Glu Arg Ala Ile Gln 
        195                 200                 205             


Arg Met Glu Lys Gly Glu His Ser Ile Val Tyr Leu Lys Pro Ser Tyr 
    210                 215                 220                 


Ala Phe Gly Ser Val Gly Lys Glu Lys Phe Gln Ile Pro Pro Asn Ala 
225                 230                 235                 240 


Glu Leu Lys Tyr Glu Leu His Leu Lys Ser Phe Glu Lys Ala Lys Glu 
                245                 250                 255     


Ser Trp Glu Met Asn Ser Glu Glu Lys Leu Glu Gln Ser Thr Ile Val 
            260                 265                 270         


Lys Glu Arg Gly Thr Val Tyr Phe Lys Glu Gly Lys Tyr Lys Gln Ala 
        275                 280                 285             


Leu Leu Gln Tyr Lys Lys Ile Val Ser Trp Leu Glu Tyr Glu Ser Ser 
    290                 295                 300                 


Phe Ser Asn Glu Glu Ala Gln Lys Ala Gln Ala Leu Arg Leu Ala Ser 
305                 310                 315                 320 


His Leu Asn Leu Ala Met Cys His Leu Lys Leu Gln Ala Phe Ser Ala 
                325                 330                 335     


Ala Ile Glu Ser Cys Asn Lys Ala Leu Glu Leu Asp Ser Asn Asn Glu 
            340                 345                 350         


Lys Gly Leu Phe Arg Arg Gly Glu Ala His Leu Ala Val Asn Asp Phe 
        355                 360                 365             


Glu Leu Ala Arg Ala Asp Phe Gln Lys Val Leu Gln Leu Tyr Pro Asn 
    370                 375                 380                 


Asn Lys Ala Ala Lys Thr Gln Leu Ala Val Cys Gln Gln Arg Ile Arg 
385                 390                 395                 400 


Arg Gln Leu Ala Arg Glu Lys Lys Leu Tyr Ala Asn Met Phe Glu Arg 
                405                 410                 415     


Leu Ala Glu Glu Glu Asn Lys Ala Lys Ala Glu Ala Ser Ser Gly Asp 
            420                 425                 430         


His Pro Thr Asp Thr Glu Met Lys Glu Glu Gln Lys Ser Asn Thr Ala 
        435                 440                 445             


Gly Ser Gln Ser Gln Val Glu Thr Glu Ala 
    450                 455             


<210>  3
<211>  457
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(457)
<223>  FKBP5

<400>  3

Met Thr Thr Asp Glu Gly Ala Lys Asn Asn Glu Glu Ser Pro Thr Ala 
1               5                   10                  15      


Thr Val Ala Glu Gln Gly Glu Asp Ile Thr Ser Lys Lys Asp Arg Gly 
            20                  25                  30          


Val Leu Lys Ile Val Lys Arg Val Gly Asn Gly Glu Glu Thr Pro Met 
        35                  40                  45              


Ile Gly Asp Lys Val Tyr Val His Tyr Lys Gly Lys Leu Ser Asn Gly 
    50                  55                  60                  


Lys Lys Phe Asp Ser Ser His Asp Arg Asn Glu Pro Phe Val Phe Ser 
65                  70                  75                  80  


Leu Gly Lys Gly Gln Val Ile Lys Ala Trp Asp Ile Gly Val Ala Thr 
                85                  90                  95      


Met Lys Lys Gly Glu Ile Cys His Leu Leu Cys Lys Pro Glu Tyr Ala 
            100                 105                 110         


Tyr Gly Ser Ala Gly Ser Leu Pro Lys Ile Pro Ser Asn Ala Thr Leu 
        115                 120                 125             


Phe Phe Glu Ile Glu Leu Leu Asp Phe Lys Gly Glu Asp Leu Phe Glu 
    130                 135                 140                 


Asp Gly Gly Ile Ile Arg Arg Thr Lys Arg Lys Gly Glu Gly Tyr Ser 
145                 150                 155                 160 


Asn Pro Asn Glu Gly Ala Thr Val Glu Ile His Leu Glu Gly Arg Cys 
                165                 170                 175     


Gly Gly Arg Met Phe Asp Cys Arg Asp Val Ala Phe Thr Val Gly Glu 
            180                 185                 190         


Gly Glu Asp His Asp Ile Pro Ile Gly Ile Asp Lys Ala Leu Glu Lys 
        195                 200                 205             


Met Gln Arg Glu Glu Gln Cys Ile Leu Tyr Leu Gly Pro Arg Tyr Gly 
    210                 215                 220                 


Phe Gly Glu Ala Gly Lys Pro Lys Phe Gly Ile Glu Pro Asn Ala Glu 
225                 230                 235                 240 


Leu Ile Tyr Glu Val Thr Leu Lys Ser Phe Glu Lys Ala Lys Glu Ser 
                245                 250                 255     


Trp Glu Met Asp Thr Lys Glu Lys Leu Glu Gln Ala Ala Ile Val Lys 
            260                 265                 270         


Glu Lys Gly Thr Val Tyr Phe Lys Gly Gly Lys Tyr Met Gln Ala Val 
        275                 280                 285             


Ile Gln Tyr Gly Lys Ile Val Ser Trp Leu Glu Met Glu Tyr Gly Leu 
    290                 295                 300                 


Ser Glu Lys Glu Ser Lys Ala Ser Glu Ser Phe Leu Leu Ala Ala Phe 
305                 310                 315                 320 


Leu Asn Leu Ala Met Cys Tyr Leu Lys Leu Arg Glu Tyr Thr Lys Ala 
                325                 330                 335     


Val Glu Cys Cys Asp Lys Ala Leu Gly Leu Asp Ser Ala Asn Glu Lys 
            340                 345                 350         


Gly Leu Tyr Arg Arg Gly Glu Ala Gln Leu Leu Met Asn Glu Phe Glu 
        355                 360                 365             


Ser Ala Lys Gly Asp Phe Glu Lys Val Leu Glu Val Asn Pro Gln Asn 
    370                 375                 380                 


Lys Ala Ala Arg Leu Gln Ile Ser Met Cys Gln Lys Lys Ala Lys Glu 
385                 390                 395                 400 


His Asn Glu Arg Asp Arg Arg Ile Tyr Ala Asn Met Phe Lys Lys Phe 
                405                 410                 415     


Ala Glu Gln Asp Ala Lys Glu Glu Ala Asn Lys Ala Met Gly Lys Lys 
            420                 425                 430         


Thr Ser Glu Gly Val Thr Asn Glu Lys Gly Thr Asp Ser Gln Ala Met 
        435                 440                 445             


Glu Glu Glu Lys Pro Glu Gly His Val 
    450                 455         


<210>  4
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  FKBP1B

<400>  4

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105         


<210>  5
<211>  329
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(329)
<223>  PPP1CA

<400>  5

Ser Asp Ser Glu Lys Leu Asn Leu Asp Ser Ile Ile Gly Arg Leu Leu 
1               5                   10                  15      


Glu Val Gln Gly Ser Arg Pro Gly Lys Asn Val Gln Leu Thr Glu Asn 
            20                  25                  30          


Glu Ile Arg Gly Leu Cys Leu Lys Ser Arg Glu Ile Phe Leu Ser Gln 
        35                  40                  45              


Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp Ile 
    50                  55                  60                  


His Gly Gln Tyr Tyr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly Phe 
65                  70                  75                  80  


Pro Pro Glu Ser Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly 
                85                  90                  95      


Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile Lys 
            100                 105                 110         


Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala Ser 
        115                 120                 125             


Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Tyr Asn 
    130                 135                 140                 


Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro Ile 
145                 150                 155                 160 


Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu Ser 
                165                 170                 175     


Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro Thr 
            180                 185                 190         


Asp Val Pro Asp Gln Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp Pro 
        195                 200                 205             


Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser Phe 
    210                 215                 220                 


Thr Phe Gly Ala Glu Val Val Ala Lys Phe Leu His Lys His Asp Leu 
225                 230                 235                 240 


Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu Phe 
                245                 250                 255     


Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr Cys 
            260                 265                 270         


Gly Glu Phe Asp Asn Ala Gly Ala Met Met Ser Val Asp Glu Thr Leu 
        275                 280                 285             


Met Cys Ser Phe Gln Ile Leu Lys Pro Ala Asp Lys Asn Lys Gly Lys 
    290                 295                 300                 


Tyr Gly Gln Phe Ser Gly Leu Asn Pro Gly Gly Arg Pro Ile Thr Pro 
305                 310                 315                 320 


Pro Arg Asn Ser Ala Lys Ala Lys Lys 
                325                 


<210>  6
<211>  309
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(309)
<223>  PPP2CA

<400>  6

Met Asp Glu Lys Val Phe Thr Lys Glu Leu Asp Gln Trp Ile Glu Gln 
1               5                   10                  15      


Leu Asn Glu Cys Lys Gln Leu Ser Glu Ser Gln Val Lys Ser Leu Cys 
            20                  25                  30          


Glu Lys Ala Lys Glu Ile Leu Thr Lys Glu Ser Asn Val Gln Glu Val 
        35                  40                  45              


Arg Cys Pro Val Thr Val Cys Gly Asp Val His Gly Gln Phe His Asp 
    50                  55                  60                  


Leu Met Glu Leu Phe Arg Ile Gly Gly Lys Ser Pro Asp Thr Asn Tyr 
65                  70                  75                  80  


Leu Phe Met Gly Asp Tyr Val Asp Arg Gly Tyr Tyr Ser Val Glu Thr 
                85                  90                  95      


Val Thr Leu Leu Val Ala Leu Lys Val Arg Tyr Arg Glu Arg Ile Thr 
            100                 105                 110         


Ile Leu Arg Gly Asn His Glu Ser Arg Gln Ile Thr Gln Val Tyr Gly 
        115                 120                 125             


Phe Tyr Asp Glu Cys Leu Arg Lys Tyr Gly Asn Ala Asn Val Trp Lys 
    130                 135                 140                 


Tyr Phe Thr Asp Leu Phe Asp Tyr Leu Pro Leu Thr Ala Leu Val Asp 
145                 150                 155                 160 


Gly Gln Ile Phe Cys Leu His Gly Gly Leu Ser Pro Ser Ile Asp Thr 
                165                 170                 175     


Leu Asp His Ile Arg Ala Leu Asp Arg Leu Gln Glu Val Pro His Glu 
            180                 185                 190         


Gly Pro Met Cys Asp Leu Leu Trp Ser Asp Pro Asp Asp Arg Gly Gly 
        195                 200                 205             


Trp Gly Ile Ser Pro Arg Gly Ala Gly Tyr Thr Phe Gly Gln Asp Ile 
    210                 215                 220                 


Ser Glu Thr Phe Asn His Ala Asn Gly Leu Thr Leu Val Ser Arg Ala 
225                 230                 235                 240 


His Gln Leu Val Met Glu Gly Tyr Asn Trp Cys His Asp Arg Asn Val 
                245                 250                 255     


Val Thr Ile Phe Ser Ala Pro Asn Tyr Cys Tyr Arg Cys Gly Asn Gln 
            260                 265                 270         


Ala Ala Ile Met Glu Leu Asp Asp Thr Leu Lys Tyr Ser Phe Leu Gln 
        275                 280                 285             


Phe Asp Pro Ala Pro Arg Arg Gly Glu Pro His Val Thr Arg Arg Thr 
    290                 295                 300                 


Pro Asp Tyr Phe Leu 
305                 


<210>  7
<211>  520
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(520)
<223>  PPP3CA

<400>  7

Ser Glu Pro Lys Ala Ile Asp Pro Lys Leu Ser Thr Thr Asp Arg Val 
1               5                   10                  15      


Val Lys Ala Val Pro Phe Pro Pro Ser His Arg Leu Thr Ala Lys Glu 
            20                  25                  30          


Val Phe Asp Asn Asp Gly Lys Pro Arg Val Asp Ile Leu Lys Ala His 
        35                  40                  45              


Leu Met Lys Glu Gly Arg Leu Glu Glu Ser Val Ala Leu Arg Ile Ile 
    50                  55                  60                  


Thr Glu Gly Ala Ser Ile Leu Arg Gln Glu Lys Asn Leu Leu Asp Ile 
65                  70                  75                  80  


Asp Ala Pro Val Thr Val Cys Gly Asp Ile His Gly Gln Phe Phe Asp 
                85                  90                  95      


Leu Met Lys Leu Phe Glu Val Gly Gly Ser Pro Ala Asn Thr Arg Tyr 
            100                 105                 110         


Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly Tyr Phe Ser Ile Glu Cys 
        115                 120                 125             


Val Leu Tyr Leu Trp Ala Leu Lys Ile Leu Tyr Pro Lys Thr Leu Phe 
    130                 135                 140                 


Leu Leu Arg Gly Asn His Glu Cys Arg His Leu Thr Glu Tyr Phe Thr 
145                 150                 155                 160 


Phe Lys Gln Glu Cys Lys Ile Lys Tyr Ser Glu Arg Val Tyr Asp Ala 
                165                 170                 175     


Cys Met Asp Ala Phe Asp Cys Leu Pro Leu Ala Ala Leu Met Asn Gln 
            180                 185                 190         


Gln Phe Leu Cys Val His Gly Gly Leu Ser Pro Glu Ile Asn Thr Leu 
        195                 200                 205             


Asp Asp Ile Arg Lys Leu Asp Arg Phe Lys Glu Pro Pro Ala Tyr Gly 
    210                 215                 220                 


Pro Met Cys Asp Ile Leu Trp Ser Asp Pro Leu Glu Asp Phe Gly Asn 
225                 230                 235                 240 


Glu Lys Thr Gln Glu His Phe Thr His Asn Thr Val Arg Gly Cys Ser 
                245                 250                 255     


Tyr Phe Tyr Ser Tyr Pro Ala Val Cys Glu Phe Leu Gln His Asn Asn 
            260                 265                 270         


Leu Leu Ser Ile Leu Arg Ala His Glu Ala Gln Asp Ala Gly Tyr Arg 
        275                 280                 285             


Met Tyr Arg Lys Ser Gln Thr Thr Gly Phe Pro Ser Leu Ile Thr Ile 
    290                 295                 300                 


Phe Ser Ala Pro Asn Tyr Leu Asp Val Tyr Asn Asn Lys Ala Ala Val 
305                 310                 315                 320 


Leu Lys Tyr Glu Asn Asn Val Met Asn Ile Arg Gln Phe Asn Cys Ser 
                325                 330                 335     


Pro His Pro Tyr Trp Leu Pro Asn Phe Met Asp Val Phe Thr Trp Ser 
            340                 345                 350         


Leu Pro Phe Val Gly Glu Lys Val Thr Glu Met Leu Val Asn Val Leu 
        355                 360                 365             


Asn Ile Cys Ser Asp Asp Glu Leu Gly Ser Glu Glu Asp Gly Phe Asp 
    370                 375                 380                 


Gly Ala Thr Ala Ala Ala Arg Lys Glu Val Ile Arg Asn Lys Ile Arg 
385                 390                 395                 400 


Ala Ile Gly Lys Met Ala Arg Val Phe Ser Val Leu Arg Glu Glu Ser 
                405                 410                 415     


Glu Ser Val Leu Thr Leu Lys Gly Leu Thr Pro Thr Gly Met Leu Pro 
            420                 425                 430         


Ser Gly Val Leu Ser Gly Gly Lys Gln Thr Leu Gln Ser Ala Thr Val 
        435                 440                 445             


Glu Ala Ile Glu Ala Asp Glu Ala Ile Lys Gly Phe Ser Pro Gln His 
    450                 455                 460                 


Lys Ile Thr Ser Phe Glu Glu Ala Lys Gly Leu Asp Arg Ile Asn Glu 
465                 470                 475                 480 


Arg Met Pro Pro Arg Arg Asp Ala Met Pro Ser Asp Ala Asn Leu Asn 
                485                 490                 495     


Ser Ile Asn Lys Ala Leu Thr Ser Glu Thr Asn Gly Thr Asp Ser Asn 
            500                 505                 510         


Gly Ser Asn Ser Ser Asn Ile Gln 
        515                 520 


<210>  8
<211>  381
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(381)
<223>  PPM1A

<400>  8

Gly Ala Phe Leu Asp Lys Pro Lys Met Glu Lys His Asn Ala Gln Gly 
1               5                   10                  15      


Gln Gly Asn Gly Leu Arg Tyr Gly Leu Ser Ser Met Gln Gly Trp Arg 
            20                  25                  30          


Val Glu Met Glu Asp Ala His Thr Ala Val Ile Gly Leu Pro Ser Gly 
        35                  40                  45              


Leu Glu Ser Trp Ser Phe Phe Ala Val Tyr Asp Gly His Ala Gly Ser 
    50                  55                  60                  


Gln Val Ala Lys Tyr Cys Cys Glu His Leu Leu Asp His Ile Thr Asn 
65                  70                  75                  80  


Asn Gln Asp Phe Lys Gly Ser Ala Gly Ala Pro Ser Val Glu Asn Val 
                85                  90                  95      


Lys Asn Gly Ile Arg Thr Gly Phe Leu Glu Ile Asp Glu His Met Arg 
            100                 105                 110         


Val Met Ser Glu Lys Lys His Gly Ala Asp Arg Ser Gly Ser Thr Ala 
        115                 120                 125             


Val Gly Val Leu Ile Ser Pro Gln His Thr Tyr Phe Ile Asn Cys Gly 
    130                 135                 140                 


Asp Ser Arg Gly Leu Leu Cys Arg Asn Arg Lys Val His Phe Phe Thr 
145                 150                 155                 160 


Gln Asp His Lys Pro Ser Asn Pro Leu Glu Lys Glu Arg Ile Gln Asn 
                165                 170                 175     


Ala Gly Gly Ser Val Met Ile Gln Arg Val Asn Gly Ser Leu Ala Val 
            180                 185                 190         


Ser Arg Ala Leu Gly Asp Phe Asp Tyr Lys Cys Val His Gly Lys Gly 
        195                 200                 205             


Pro Thr Glu Gln Leu Val Ser Pro Glu Pro Glu Val His Asp Ile Glu 
    210                 215                 220                 


Arg Ser Glu Glu Asp Asp Gln Phe Ile Ile Leu Ala Cys Asp Gly Ile 
225                 230                 235                 240 


Trp Asp Val Met Gly Asn Glu Glu Leu Cys Asp Phe Val Arg Ser Arg 
                245                 250                 255     


Leu Glu Val Thr Asp Asp Leu Glu Lys Val Cys Asn Glu Val Val Asp 
            260                 265                 270         


Thr Cys Leu Tyr Lys Gly Ser Arg Asp Asn Met Ser Val Ile Leu Ile 
        275                 280                 285             


Cys Phe Pro Asn Ala Pro Lys Val Ser Pro Glu Ala Val Lys Lys Glu 
    290                 295                 300                 


Ala Glu Leu Asp Lys Tyr Leu Glu Cys Arg Val Glu Glu Ile Ile Lys 
305                 310                 315                 320 


Lys Gln Gly Glu Gly Val Pro Asp Leu Val His Val Met Arg Thr Leu 
                325                 330                 335     


Ala Ser Glu Asn Ile Pro Ser Leu Pro Pro Gly Gly Glu Leu Ala Ser 
            340                 345                 350         


Lys Arg Asn Val Ile Glu Ala Val Tyr Asn Arg Leu Asn Pro Tyr Lys 
        355                 360                 365             


Asn Asp Asp Thr Asp Ser Thr Ser Thr Asp Asp Met Trp 
    370                 375                 380     


<210>  9
<211>  370
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(370)
<223>  Cyclophilin D

<400>  9

Met Ser His Pro Ser Pro Gln Ala Lys Pro Ser Asn Pro Ser Asn Pro 
1               5                   10                  15      


Arg Val Phe Phe Asp Val Asp Ile Gly Gly Glu Arg Val Gly Arg Ile 
            20                  25                  30          


Val Leu Glu Leu Phe Ala Asp Ile Val Pro Lys Thr Ala Glu Asn Phe 
        35                  40                  45              


Arg Ala Leu Cys Thr Gly Glu Lys Gly Ile Gly His Thr Thr Gly Lys 
    50                  55                  60                  


Pro Leu His Phe Lys Gly Cys Pro Phe His Arg Ile Ile Lys Lys Phe 
65                  70                  75                  80  


Met Ile Gln Gly Gly Asp Phe Ser Asn Gln Asn Gly Thr Gly Gly Glu 
                85                  90                  95      


Ser Ile Tyr Gly Glu Lys Phe Glu Asp Glu Asn Phe His Tyr Lys His 
            100                 105                 110         


Asp Arg Glu Gly Leu Leu Ser Met Ala Asn Ala Gly Arg Asn Thr Asn 
        115                 120                 125             


Gly Ser Gln Phe Phe Ile Thr Thr Val Pro Thr Pro His Leu Asp Gly 
    130                 135                 140                 


Lys His Val Val Phe Gly Gln Val Ile Lys Gly Ile Gly Val Ala Arg 
145                 150                 155                 160 


Ile Leu Glu Asn Val Glu Val Lys Gly Glu Lys Pro Ala Lys Leu Cys 
                165                 170                 175     


Val Ile Ala Glu Cys Gly Glu Leu Lys Glu Gly Asp Asp Gly Gly Ile 
            180                 185                 190         


Phe Pro Lys Asp Gly Ser Gly Asp Ser His Pro Asp Phe Pro Glu Asp 
        195                 200                 205             


Ala Asp Ile Asp Leu Lys Asp Val Asp Lys Ile Leu Leu Ile Thr Glu 
    210                 215                 220                 


Asp Leu Lys Asn Ile Gly Asn Thr Phe Phe Lys Ser Gln Asn Trp Glu 
225                 230                 235                 240 


Met Ala Ile Lys Lys Tyr Ala Glu Val Leu Arg Tyr Val Asp Ser Ser 
                245                 250                 255     


Lys Ala Val Ile Glu Thr Ala Asp Arg Ala Lys Leu Gln Pro Ile Ala 
            260                 265                 270         


Leu Ser Cys Val Leu Asn Ile Gly Ala Cys Lys Leu Lys Met Ser Asn 
        275                 280                 285             


Trp Gln Gly Ala Ile Asp Ser Cys Leu Glu Ala Leu Glu Leu Asp Pro 
    290                 295                 300                 


Ser Asn Thr Lys Ala Leu Tyr Arg Arg Ala Gln Gly Trp Gln Gly Leu 
305                 310                 315                 320 


Lys Glu Tyr Asp Gln Ala Leu Ala Asp Leu Lys Lys Ala Gln Gly Ile 
                325                 330                 335     


Ala Pro Glu Asp Lys Ala Ile Gln Ala Glu Leu Leu Lys Val Lys Gln 
            340                 345                 350         


Lys Ile Lys Ala Gln Lys Asp Lys Glu Lys Ala Val Tyr Ala Lys Met 
        355                 360                 365             


Phe Ala 
    370 


<210>  10
<211>  370
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(370)
<223>  Cyclophilin 40

<400>  10

Met Ser His Pro Ser Pro Gln Ala Lys Pro Ser Asn Pro Ser Asn Pro 
1               5                   10                  15      


Arg Val Phe Phe Asp Val Asp Ile Gly Gly Glu Arg Val Gly Arg Ile 
            20                  25                  30          


Val Leu Glu Leu Phe Ala Asp Ile Val Pro Lys Thr Ala Glu Asn Phe 
        35                  40                  45              


Arg Ala Leu Cys Thr Gly Glu Lys Gly Ile Gly His Thr Thr Gly Lys 
    50                  55                  60                  


Pro Leu His Phe Lys Gly Cys Pro Phe His Arg Ile Ile Lys Lys Phe 
65                  70                  75                  80  


Met Ile Gln Gly Gly Asp Phe Ser Asn Gln Asn Gly Thr Gly Gly Glu 
                85                  90                  95      


Ser Ile Tyr Gly Glu Lys Phe Glu Asp Glu Asn Phe His Tyr Lys His 
            100                 105                 110         


Asp Arg Glu Gly Leu Leu Ser Met Ala Asn Ala Gly Arg Asn Thr Asn 
        115                 120                 125             


Gly Ser Gln Phe Phe Ile Thr Thr Val Pro Thr Pro His Leu Asp Gly 
    130                 135                 140                 


Lys His Val Val Phe Gly Gln Val Ile Lys Gly Ile Gly Val Ala Arg 
145                 150                 155                 160 


Ile Leu Glu Asn Val Glu Val Lys Gly Glu Lys Pro Ala Lys Leu Cys 
                165                 170                 175     


Val Ile Ala Glu Cys Gly Glu Leu Lys Glu Gly Asp Asp Gly Gly Ile 
            180                 185                 190         


Phe Pro Lys Asp Gly Ser Gly Asp Ser His Pro Asp Phe Pro Glu Asp 
        195                 200                 205             


Ala Asp Ile Asp Leu Lys Asp Val Asp Lys Ile Leu Leu Ile Thr Glu 
    210                 215                 220                 


Asp Leu Lys Asn Ile Gly Asn Thr Phe Phe Lys Ser Gln Asn Trp Glu 
225                 230                 235                 240 


Met Ala Ile Lys Lys Tyr Ala Glu Val Leu Arg Tyr Val Asp Ser Ser 
                245                 250                 255     


Lys Ala Val Ile Glu Thr Ala Asp Arg Ala Lys Leu Gln Pro Ile Ala 
            260                 265                 270         


Leu Ser Cys Val Leu Asn Ile Gly Ala Cys Lys Leu Lys Met Ser Asn 
        275                 280                 285             


Trp Gln Gly Ala Ile Asp Ser Cys Leu Glu Ala Leu Glu Leu Asp Pro 
    290                 295                 300                 


Ser Asn Thr Lys Ala Leu Tyr Arg Arg Ala Gln Gly Trp Gln Gly Leu 
305                 310                 315                 320 


Lys Glu Tyr Asp Gln Ala Leu Ala Asp Leu Lys Lys Ala Gln Gly Ile 
                325                 330                 335     


Ala Pro Glu Asp Lys Ala Ile Gln Ala Glu Leu Leu Lys Val Lys Gln 
            340                 345                 350         


Lys Ile Lys Ala Gln Lys Asp Lys Glu Lys Ala Val Tyr Ala Lys Met 
        355                 360                 365             


Phe Ala 
    370 


<210>  11
<211>  521
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(521)
<223>  Calcineurin

<400>  11

Met Ser Glu Pro Lys Ala Ile Asp Pro Lys Leu Ser Thr Thr Asp Arg 
1               5                   10                  15      


Val Val Lys Ala Val Pro Phe Pro Pro Ser His Arg Leu Thr Ala Lys 
            20                  25                  30          


Glu Val Phe Asp Asn Asp Gly Lys Pro Arg Val Asp Ile Leu Lys Ala 
        35                  40                  45              


His Leu Met Lys Glu Gly Arg Leu Glu Glu Ser Val Ala Leu Arg Ile 
    50                  55                  60                  


Ile Thr Glu Gly Ala Ser Ile Leu Arg Gln Glu Lys Asn Leu Leu Asp 
65                  70                  75                  80  


Ile Asp Ala Pro Val Thr Val Cys Gly Asp Ile His Gly Gln Phe Phe 
                85                  90                  95      


Asp Leu Met Lys Leu Phe Glu Val Gly Gly Ser Pro Ala Asn Thr Arg 
            100                 105                 110         


Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly Tyr Phe Ser Ile Glu 
        115                 120                 125             


Cys Val Leu Tyr Leu Trp Ala Leu Lys Ile Leu Tyr Pro Lys Thr Leu 
    130                 135                 140                 


Phe Leu Leu Arg Gly Asn His Glu Cys Arg His Leu Thr Glu Tyr Phe 
145                 150                 155                 160 


Thr Phe Lys Gln Glu Cys Lys Ile Lys Tyr Ser Glu Arg Val Tyr Asp 
                165                 170                 175     


Ala Cys Met Asp Ala Phe Asp Cys Leu Pro Leu Ala Ala Leu Met Asn 
            180                 185                 190         


Gln Gln Phe Leu Cys Val His Gly Gly Leu Ser Pro Glu Ile Asn Thr 
        195                 200                 205             


Leu Asp Asp Ile Arg Lys Leu Asp Arg Phe Lys Glu Pro Pro Ala Tyr 
    210                 215                 220                 


Gly Pro Met Cys Asp Ile Leu Trp Ser Asp Pro Leu Glu Asp Phe Gly 
225                 230                 235                 240 


Asn Glu Lys Thr Gln Glu His Phe Thr His Asn Thr Val Arg Gly Cys 
                245                 250                 255     


Ser Tyr Phe Tyr Ser Tyr Pro Ala Val Cys Glu Phe Leu Gln His Asn 
            260                 265                 270         


Asn Leu Leu Ser Ile Leu Arg Ala His Glu Ala Gln Asp Ala Gly Tyr 
        275                 280                 285             


Arg Met Tyr Arg Lys Ser Gln Thr Thr Gly Phe Pro Ser Leu Ile Thr 
    290                 295                 300                 


Ile Phe Ser Ala Pro Asn Tyr Leu Asp Val Tyr Asn Asn Lys Ala Ala 
305                 310                 315                 320 


Val Leu Lys Tyr Glu Asn Asn Val Met Asn Ile Arg Gln Phe Asn Cys 
                325                 330                 335     


Ser Pro His Pro Tyr Trp Leu Pro Asn Phe Met Asp Val Phe Thr Trp 
            340                 345                 350         


Ser Leu Pro Phe Val Gly Glu Lys Val Thr Glu Met Leu Val Asn Val 
        355                 360                 365             


Leu Asn Ile Cys Ser Asp Asp Glu Leu Gly Ser Glu Glu Asp Gly Phe 
    370                 375                 380                 


Asp Gly Ala Thr Ala Ala Ala Arg Lys Glu Val Ile Arg Asn Lys Ile 
385                 390                 395                 400 


Arg Ala Ile Gly Lys Met Ala Arg Val Phe Ser Val Leu Arg Glu Glu 
                405                 410                 415     


Ser Glu Ser Val Leu Thr Leu Lys Gly Leu Thr Pro Thr Gly Met Leu 
            420                 425                 430         


Pro Ser Gly Val Leu Ser Gly Gly Lys Gln Thr Leu Gln Ser Ala Thr 
        435                 440                 445             


Val Glu Ala Ile Glu Ala Asp Glu Ala Ile Lys Gly Phe Ser Pro Gln 
    450                 455                 460                 


His Lys Ile Thr Ser Phe Glu Glu Ala Lys Gly Leu Asp Arg Ile Asn 
465                 470                 475                 480 


Glu Arg Met Pro Pro Arg Arg Asp Ala Met Pro Ser Asp Ala Asn Leu 
                485                 490                 495     


Asn Ser Ile Asn Lys Ala Leu Thr Ser Glu Thr Asn Gly Thr Asp Ser 
            500                 505                 510         


Asn Gly Ser Asn Ser Ser Asn Ile Gln 
        515                 520     


<210>  12
<211>  747
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(747)
<223>  SIRT1

<400>  12

Met Ala Asp Glu Ala Ala Leu Ala Leu Gln Pro Gly Gly Ser Pro Ser 
1               5                   10                  15      


Ala Ala Gly Ala Asp Arg Glu Ala Ala Ser Ser Pro Ala Gly Glu Pro 
            20                  25                  30          


Leu Arg Lys Arg Pro Arg Arg Asp Gly Pro Gly Leu Glu Arg Ser Pro 
        35                  40                  45              


Gly Glu Pro Gly Gly Ala Ala Pro Glu Arg Glu Val Pro Ala Ala Ala 
    50                  55                  60                  


Arg Gly Cys Pro Gly Ala Ala Ala Ala Ala Leu Trp Arg Glu Ala Glu 
65                  70                  75                  80  


Ala Glu Ala Ala Ala Ala Gly Gly Glu Gln Glu Ala Gln Ala Thr Ala 
                85                  90                  95      


Ala Ala Gly Glu Gly Asp Asn Gly Pro Gly Leu Gln Gly Pro Ser Arg 
            100                 105                 110         


Glu Pro Pro Leu Ala Asp Asn Leu Tyr Asp Glu Asp Asp Asp Asp Glu 
        115                 120                 125             


Gly Glu Glu Glu Glu Glu Ala Ala Ala Ala Ala Ile Gly Tyr Arg Asp 
    130                 135                 140                 


Asn Leu Leu Phe Gly Asp Glu Ile Ile Thr Asn Gly Phe His Ser Cys 
145                 150                 155                 160 


Glu Ser Asp Glu Glu Asp Arg Ala Ser His Ala Ser Ser Ser Asp Trp 
                165                 170                 175     


Thr Pro Arg Pro Arg Ile Gly Pro Tyr Thr Phe Val Gln Gln His Leu 
            180                 185                 190         


Met Ile Gly Thr Asp Pro Arg Thr Ile Leu Lys Asp Leu Leu Pro Glu 
        195                 200                 205             


Thr Ile Pro Pro Pro Glu Leu Asp Asp Met Thr Leu Trp Gln Ile Val 
    210                 215                 220                 


Ile Asn Ile Leu Ser Glu Pro Pro Lys Arg Lys Lys Arg Lys Asp Ile 
225                 230                 235                 240 


Asn Thr Ile Glu Asp Ala Val Lys Leu Leu Gln Glu Cys Lys Lys Ile 
                245                 250                 255     


Ile Val Leu Thr Gly Ala Gly Val Ser Val Ser Cys Gly Ile Pro Asp 
            260                 265                 270         


Phe Arg Ser Arg Asp Gly Ile Tyr Ala Arg Leu Ala Val Asp Phe Pro 
        275                 280                 285             


Asp Leu Pro Asp Pro Gln Ala Met Phe Asp Ile Glu Tyr Phe Arg Lys 
    290                 295                 300                 


Asp Pro Arg Pro Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln 
305                 310                 315                 320 


Phe Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys Glu 
                325                 330                 335     


Gly Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln 
            340                 345                 350         


Val Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala Thr 
        355                 360                 365             


Ala Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val Arg 
    370                 375                 380                 


Gly Asp Ile Phe Asn Gln Val Val Pro Arg Cys Pro Arg Cys Pro Ala 
385                 390                 395                 400 


Asp Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly Glu 
                405                 410                 415     


Asn Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp Glu 
            420                 425                 430         


Val Asp Leu Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg Pro Val 
        435                 440                 445             


Ala Leu Ile Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile Leu Ile 
    450                 455                 460                 


Asn Arg Glu Pro Leu Pro His Leu His Phe Asp Val Glu Leu Leu Gly 
465                 470                 475                 480 


Asp Cys Asp Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly Gly Glu 
                485                 490                 495     


Tyr Ala Lys Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile Thr Glu 
            500                 505                 510         


Lys Pro Pro Arg Thr Gln Lys Glu Leu Ala Tyr Leu Ser Glu Leu Pro 
        515                 520                 525             


Pro Thr Pro Leu His Val Ser Glu Asp Ser Ser Ser Pro Glu Arg Thr 
    530                 535                 540                 


Ser Pro Pro Asp Ser Ser Val Ile Val Thr Leu Leu Asp Gln Ala Ala 
545                 550                 555                 560 


Lys Ser Asn Asp Asp Leu Asp Val Ser Glu Ser Lys Gly Cys Met Glu 
                565                 570                 575     


Glu Lys Pro Gln Glu Val Gln Thr Ser Arg Asn Val Glu Ser Ile Ala 
            580                 585                 590         


Glu Gln Met Glu Asn Pro Asp Leu Lys Asn Val Gly Ser Ser Thr Gly 
        595                 600                 605             


Glu Lys Asn Glu Arg Thr Ser Val Ala Gly Thr Val Arg Lys Cys Trp 
    610                 615                 620                 


Pro Asn Arg Val Ala Lys Glu Gln Ile Ser Arg Arg Leu Asp Gly Asn 
625                 630                 635                 640 


Gln Tyr Leu Phe Leu Pro Pro Asn Arg Tyr Ile Phe His Gly Ala Glu 
                645                 650                 655     


Val Tyr Ser Asp Ser Glu Asp Asp Val Leu Ser Ser Ser Ser Cys Gly 
            660                 665                 670         


Ser Asn Ser Asp Ser Gly Thr Cys Gln Ser Pro Ser Leu Glu Glu Pro 
        675                 680                 685             


Met Glu Asp Glu Ser Glu Ile Glu Glu Phe Tyr Asn Gly Leu Glu Asp 
    690                 695                 700                 


Glu Pro Asp Val Pro Glu Arg Ala Gly Gly Ala Gly Phe Gly Thr Asp 
705                 710                 715                 720 


Gly Asp Asp Gln Glu Ala Ile Asn Glu Ala Ile Ser Val Lys Gln Glu 
                725                 730                 735     


Val Thr Asp Met Asn Tyr Pro Ser Asn Lys Ser 
            740                 745         


<210>  13
<211>  352
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(352)
<223>  SIRT2

<400>  13

Met Asp Phe Leu Arg Asn Leu Phe Ser Gln Thr Leu Ser Leu Gly Ser 
1               5                   10                  15      


Gln Lys Glu Arg Leu Leu Asp Glu Leu Thr Leu Glu Gly Val Ala Arg 
            20                  25                  30          


Tyr Met Gln Ser Glu Arg Cys Arg Arg Val Ile Cys Leu Val Gly Ala 
        35                  40                  45              


Gly Ile Ser Thr Ser Ala Gly Ile Pro Asp Phe Arg Ser Pro Ser Thr 
    50                  55                  60                  


Gly Leu Tyr Asp Asn Leu Glu Lys Tyr His Leu Pro Tyr Pro Glu Ala 
65                  70                  75                  80  


Ile Phe Glu Ile Ser Tyr Phe Lys Lys His Pro Glu Pro Phe Phe Ala 
                85                  90                  95      


Leu Ala Lys Glu Leu Tyr Pro Gly Gln Phe Lys Pro Thr Ile Cys His 
            100                 105                 110         


Tyr Phe Met Arg Leu Leu Lys Asp Lys Gly Leu Leu Leu Arg Cys Tyr 
        115                 120                 125             


Thr Gln Asn Ile Asp Thr Leu Glu Arg Ile Ala Gly Leu Glu Gln Glu 
    130                 135                 140                 


Asp Leu Val Glu Ala His Gly Thr Phe Tyr Thr Ser His Cys Val Ser 
145                 150                 155                 160 


Ala Ser Cys Arg His Glu Tyr Pro Leu Ser Trp Met Lys Glu Lys Ile 
                165                 170                 175     


Phe Ser Glu Val Thr Pro Lys Cys Glu Asp Cys Gln Ser Leu Val Lys 
            180                 185                 190         


Pro Asp Ile Val Phe Phe Gly Glu Ser Leu Pro Ala Arg Phe Phe Ser 
        195                 200                 205             


Cys Met Gln Ser Asp Phe Leu Lys Val Asp Leu Leu Leu Val Met Gly 
    210                 215                 220                 


Thr Ser Leu Gln Val Gln Pro Phe Ala Ser Leu Ile Ser Lys Ala Pro 
225                 230                 235                 240 


Leu Ser Thr Pro Arg Leu Leu Ile Asn Lys Glu Lys Ala Gly Gln Ser 
                245                 250                 255     


Asp Pro Phe Leu Gly Met Ile Met Gly Leu Gly Gly Gly Met Asp Phe 
            260                 265                 270         


Asp Ser Lys Lys Ala Tyr Arg Asp Val Ala Trp Leu Gly Glu Cys Asp 
        275                 280                 285             


Gln Gly Cys Leu Ala Leu Ala Glu Leu Leu Gly Trp Lys Lys Glu Leu 
    290                 295                 300                 


Glu Asp Leu Val Arg Arg Glu His Ala Ser Ile Asp Ala Gln Ser Gly 
305                 310                 315                 320 


Ala Gly Val Pro Asn Pro Ser Thr Ser Ala Ser Pro Lys Lys Ser Pro 
                325                 330                 335     


Pro Pro Ala Lys Asp Glu Ala Arg Thr Thr Glu Arg Glu Lys Pro Gln 
            340                 345                 350         


<210>  14
<211>  399
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(399)
<223>  SIRT3

<400>  14

Met Ala Phe Trp Gly Trp Arg Ala Ala Ala Ala Leu Arg Leu Trp Gly 
1               5                   10                  15      


Arg Val Val Glu Arg Val Glu Ala Gly Gly Gly Val Gly Pro Phe Gln 
            20                  25                  30          


Ala Cys Gly Cys Arg Leu Val Leu Gly Gly Arg Asp Asp Val Ser Ala 
        35                  40                  45              


Gly Leu Arg Gly Ser His Gly Ala Arg Gly Glu Pro Leu Asp Pro Ala 
    50                  55                  60                  


Arg Pro Leu Gln Arg Pro Pro Arg Pro Glu Val Pro Arg Ala Phe Arg 
65                  70                  75                  80  


Arg Gln Pro Arg Ala Ala Ala Pro Ser Phe Phe Phe Ser Ser Ile Lys 
                85                  90                  95      


Gly Gly Arg Arg Ser Ile Ser Phe Ser Val Gly Ala Ser Ser Val Val 
            100                 105                 110         


Gly Ser Gly Gly Ser Ser Asp Lys Gly Lys Leu Ser Leu Gln Asp Val 
        115                 120                 125             


Ala Glu Leu Ile Arg Ala Arg Ala Cys Gln Arg Val Val Val Met Val 
    130                 135                 140                 


Gly Ala Gly Ile Ser Thr Pro Ser Gly Ile Pro Asp Phe Arg Ser Pro 
145                 150                 155                 160 


Gly Ser Gly Leu Tyr Ser Asn Leu Gln Gln Tyr Asp Leu Pro Tyr Pro 
                165                 170                 175     


Glu Ala Ile Phe Glu Leu Pro Phe Phe Phe His Asn Pro Lys Pro Phe 
            180                 185                 190         


Phe Thr Leu Ala Lys Glu Leu Tyr Pro Gly Asn Tyr Lys Pro Asn Val 
        195                 200                 205             


Thr His Tyr Phe Leu Arg Leu Leu His Asp Lys Gly Leu Leu Leu Arg 
    210                 215                 220                 


Leu Tyr Thr Gln Asn Ile Asp Gly Leu Glu Arg Val Ser Gly Ile Pro 
225                 230                 235                 240 


Ala Ser Lys Leu Val Glu Ala His Gly Thr Phe Ala Ser Ala Thr Cys 
                245                 250                 255     


Thr Val Cys Gln Arg Pro Phe Pro Gly Glu Asp Ile Arg Ala Asp Val 
            260                 265                 270         


Met Ala Asp Arg Val Pro Arg Cys Pro Val Cys Thr Gly Val Val Lys 
        275                 280                 285             


Pro Asp Ile Val Phe Phe Gly Glu Pro Leu Pro Gln Arg Phe Leu Leu 
    290                 295                 300                 


His Val Val Asp Phe Pro Met Ala Asp Leu Leu Leu Ile Leu Gly Thr 
305                 310                 315                 320 


Ser Leu Glu Val Glu Pro Phe Ala Ser Leu Thr Glu Ala Val Arg Ser 
                325                 330                 335     


Ser Val Pro Arg Leu Leu Ile Asn Arg Asp Leu Val Gly Pro Leu Ala 
            340                 345                 350         


Trp His Pro Arg Ser Arg Asp Val Ala Gln Leu Gly Asp Val Val His 
        355                 360                 365             


Gly Val Glu Ser Leu Val Glu Leu Leu Gly Trp Thr Glu Glu Met Arg 
    370                 375                 380                 


Asp Leu Val Gln Arg Glu Thr Gly Lys Leu Asp Gly Pro Asp Lys 
385                 390                 395                 


<210>  15
<211>  314
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(314)
<223>  SIRT4

<400>  15

Met Lys Met Ser Phe Ala Leu Thr Phe Arg Ser Ala Lys Gly Arg Trp 
1               5                   10                  15      


Ile Ala Asn Pro Ser Gln Pro Cys Ser Lys Ala Ser Ile Gly Leu Phe 
            20                  25                  30          


Val Pro Ala Ser Pro Pro Leu Asp Pro Glu Lys Val Lys Glu Leu Gln 
        35                  40                  45              


Arg Phe Ile Thr Leu Ser Lys Arg Leu Leu Val Met Thr Gly Ala Gly 
    50                  55                  60                  


Ile Ser Thr Glu Ser Gly Ile Pro Asp Tyr Arg Ser Glu Lys Val Gly 
65                  70                  75                  80  


Leu Tyr Ala Arg Thr Asp Arg Arg Pro Ile Gln His Gly Asp Phe Val 
                85                  90                  95      


Arg Ser Ala Pro Ile Arg Gln Arg Tyr Trp Ala Arg Asn Phe Val Gly 
            100                 105                 110         


Trp Pro Gln Phe Ser Ser His Gln Pro Asn Pro Ala His Trp Ala Leu 
        115                 120                 125             


Ser Thr Trp Glu Lys Leu Gly Lys Leu Tyr Trp Leu Val Thr Gln Asn 
    130                 135                 140                 


Val Asp Ala Leu His Thr Lys Ala Gly Ser Arg Arg Leu Thr Glu Leu 
145                 150                 155                 160 


His Gly Cys Met Asp Arg Val Leu Cys Leu Asp Cys Gly Glu Gln Thr 
                165                 170                 175     


Pro Arg Gly Val Leu Gln Glu Arg Phe Gln Val Leu Asn Pro Thr Trp 
            180                 185                 190         


Ser Ala Glu Ala His Gly Leu Ala Pro Asp Gly Asp Val Phe Leu Ser 
        195                 200                 205             


Glu Glu Gln Val Arg Ser Phe Gln Val Pro Thr Cys Val Gln Cys Gly 
    210                 215                 220                 


Gly His Leu Lys Pro Asp Val Val Phe Phe Gly Asp Thr Val Asn Pro 
225                 230                 235                 240 


Asp Lys Val Asp Phe Val His Lys Arg Val Lys Glu Ala Asp Ser Leu 
                245                 250                 255     


Leu Val Val Gly Ser Ser Leu Gln Val Tyr Ser Gly Tyr Arg Phe Ile 
            260                 265                 270         


Leu Thr Ala Trp Glu Lys Lys Leu Pro Ile Ala Ile Leu Asn Ile Gly 
        275                 280                 285             


Pro Thr Arg Ser Asp Asp Leu Ala Cys Leu Lys Leu Asn Ser Arg Cys 
    290                 295                 300                 


Gly Glu Leu Leu Pro Leu Ile Asp Pro Cys 
305                 310                 


<210>  16
<211>  310
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(310)
<223>  SIRT5

<400>  16

Met Arg Pro Leu Gln Ile Val Pro Ser Arg Leu Ile Ser Gln Leu Tyr 
1               5                   10                  15      


Cys Gly Leu Lys Pro Pro Ala Ser Thr Arg Asn Gln Ile Cys Leu Lys 
            20                  25                  30          


Met Ala Arg Pro Ser Ser Ser Met Ala Asp Phe Arg Lys Phe Phe Ala 
        35                  40                  45              


Lys Ala Lys His Ile Val Ile Ile Ser Gly Ala Gly Val Ser Ala Glu 
    50                  55                  60                  


Ser Gly Val Pro Thr Phe Arg Gly Ala Gly Gly Tyr Trp Arg Lys Trp 
65                  70                  75                  80  


Gln Ala Gln Asp Leu Ala Thr Pro Leu Ala Phe Ala His Asn Pro Ser 
                85                  90                  95      


Arg Val Trp Glu Phe Tyr His Tyr Arg Arg Glu Val Met Gly Ser Lys 
            100                 105                 110         


Glu Pro Asn Ala Gly His Arg Ala Ile Ala Glu Cys Glu Thr Arg Leu 
        115                 120                 125             


Gly Lys Gln Gly Arg Arg Val Val Val Ile Thr Gln Asn Ile Asp Glu 
    130                 135                 140                 


Leu His Arg Lys Ala Gly Thr Lys Asn Leu Leu Glu Ile His Gly Ser 
145                 150                 155                 160 


Leu Phe Lys Thr Arg Cys Thr Ser Cys Gly Val Val Ala Glu Asn Tyr 
                165                 170                 175     


Lys Ser Pro Ile Cys Pro Ala Leu Ser Gly Lys Gly Ala Pro Glu Pro 
            180                 185                 190         


Gly Thr Gln Asp Ala Ser Ile Pro Val Glu Lys Leu Pro Arg Cys Glu 
        195                 200                 205             


Glu Ala Gly Cys Gly Gly Leu Leu Arg Pro His Val Val Trp Phe Gly 
    210                 215                 220                 


Glu Asn Leu Asp Pro Ala Ile Leu Glu Glu Val Asp Arg Glu Leu Ala 
225                 230                 235                 240 


His Cys Asp Leu Cys Leu Val Val Gly Thr Ser Ser Val Val Tyr Pro 
                245                 250                 255     


Ala Ala Met Phe Ala Pro Gln Val Ala Ala Arg Gly Val Pro Val Ala 
            260                 265                 270         


Glu Phe Asn Thr Glu Thr Thr Pro Ala Thr Asn Arg Phe Arg Phe His 
        275                 280                 285             


Phe Gln Gly Pro Cys Gly Thr Thr Leu Pro Glu Ala Leu Ala Cys His 
    290                 295                 300                 


Glu Asn Glu Thr Val Ser 
305                 310 


<210>  17
<211>  355
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(355)
<223>  SIRT6

<400>  17

Met Ser Val Asn Tyr Ala Ala Gly Leu Ser Pro Tyr Ala Asp Lys Gly 
1               5                   10                  15      


Lys Cys Gly Leu Pro Glu Ile Phe Asp Pro Pro Glu Glu Leu Glu Arg 
            20                  25                  30          


Lys Val Trp Glu Leu Ala Arg Leu Val Arg Gln Ser Ser Ser Val Val 
        35                  40                  45              


Phe His Thr Gly Ala Gly Ile Ser Thr Ala Ser Gly Ile Pro Asp Phe 
    50                  55                  60                  


Arg Gly Pro His Gly Val Trp Thr Met Glu Glu Arg Gly Leu Ala Pro 
65                  70                  75                  80  


Lys Phe Asp Thr Thr Phe Glu Ser Ala Arg Pro Thr Gln Thr His Met 
                85                  90                  95      


Ala Leu Val Gln Leu Glu Arg Val Gly Leu Leu Arg Phe Leu Val Ser 
            100                 105                 110         


Gln Asn Val Asp Gly Leu His Val Arg Ser Gly Phe Pro Arg Asp Lys 
        115                 120                 125             


Leu Ala Glu Leu His Gly Asn Met Phe Val Glu Glu Cys Ala Lys Cys 
    130                 135                 140                 


Lys Thr Gln Tyr Val Arg Asp Thr Val Val Gly Thr Met Gly Leu Lys 
145                 150                 155                 160 


Ala Thr Gly Arg Leu Cys Thr Val Ala Lys Ala Arg Gly Leu Arg Ala 
                165                 170                 175     


Cys Arg Gly Glu Leu Arg Asp Thr Ile Leu Asp Trp Glu Asp Ser Leu 
            180                 185                 190         


Pro Asp Arg Asp Leu Ala Leu Ala Asp Glu Ala Ser Arg Asn Ala Asp 
        195                 200                 205             


Leu Ser Ile Thr Leu Gly Thr Ser Leu Gln Ile Arg Pro Ser Gly Asn 
    210                 215                 220                 


Leu Pro Leu Ala Thr Lys Arg Arg Gly Gly Arg Leu Val Ile Val Asn 
225                 230                 235                 240 


Leu Gln Pro Thr Lys His Asp Arg His Ala Asp Leu Arg Ile His Gly 
                245                 250                 255     


Tyr Val Asp Glu Val Met Thr Arg Leu Met Lys His Leu Gly Leu Glu 
            260                 265                 270         


Ile Pro Ala Trp Asp Gly Pro Arg Val Leu Glu Arg Ala Leu Pro Pro 
        275                 280                 285             


Leu Pro Arg Pro Pro Thr Pro Lys Leu Glu Pro Lys Glu Glu Ser Pro 
    290                 295                 300                 


Thr Arg Ile Asn Gly Ser Ile Pro Ala Gly Pro Lys Gln Glu Pro Cys 
305                 310                 315                 320 


Ala Gln His Asn Gly Ser Glu Pro Ala Ser Pro Lys Arg Glu Arg Pro 
                325                 330                 335     


Thr Ser Pro Ala Pro His Arg Pro Pro Lys Arg Val Lys Ala Lys Ala 
            340                 345                 350         


Val Pro Ser 
        355 


<210>  18
<211>  400
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(400)
<223>  SIRT7

<400>  18

Met Ala Ala Gly Gly Leu Ser Arg Ser Glu Arg Lys Ala Ala Glu Arg 
1               5                   10                  15      


Val Arg Arg Leu Arg Glu Glu Gln Gln Arg Glu Arg Leu Arg Gln Val 
            20                  25                  30          


Ser Arg Ile Leu Arg Lys Ala Ala Ala Glu Arg Ser Ala Glu Glu Gly 
        35                  40                  45              


Arg Leu Leu Ala Glu Ser Ala Asp Leu Val Thr Glu Leu Gln Gly Arg 
    50                  55                  60                  


Ser Arg Arg Arg Glu Gly Leu Lys Arg Arg Gln Glu Glu Val Cys Asp 
65                  70                  75                  80  


Asp Pro Glu Glu Leu Arg Gly Lys Val Arg Glu Leu Ala Ser Ala Val 
                85                  90                  95      


Arg Asn Ala Lys Tyr Leu Val Val Tyr Thr Gly Ala Gly Ile Ser Thr 
            100                 105                 110         


Ala Ala Ser Ile Pro Asp Tyr Arg Gly Pro Asn Gly Val Trp Thr Leu 
        115                 120                 125             


Leu Gln Lys Gly Arg Ser Val Ser Ala Ala Asp Leu Ser Glu Ala Glu 
    130                 135                 140                 


Pro Thr Leu Thr His Met Ser Ile Thr Arg Leu His Glu Gln Lys Leu 
145                 150                 155                 160 


Val Gln His Val Val Ser Gln Asn Cys Asp Gly Leu His Leu Arg Ser 
                165                 170                 175     


Gly Leu Pro Arg Thr Ala Ile Ser Glu Leu His Gly Asn Met Tyr Ile 
            180                 185                 190         


Glu Val Cys Thr Ser Cys Val Pro Asn Arg Glu Tyr Val Arg Val Phe 
        195                 200                 205             


Asp Val Thr Glu Arg Thr Ala Leu His Arg His Gln Thr Gly Arg Thr 
    210                 215                 220                 


Cys His Lys Cys Gly Thr Gln Leu Arg Asp Thr Ile Val His Phe Gly 
225                 230                 235                 240 


Glu Arg Gly Thr Leu Gly Gln Pro Leu Asn Trp Glu Ala Ala Thr Glu 
                245                 250                 255     


Ala Ala Ser Arg Ala Asp Thr Ile Leu Cys Leu Gly Ser Ser Leu Lys 
            260                 265                 270         


Val Leu Lys Lys Tyr Pro Arg Leu Trp Cys Met Thr Lys Pro Pro Ser 
        275                 280                 285             


Arg Arg Pro Lys Leu Tyr Ile Val Asn Leu Gln Trp Thr Pro Lys Asp 
    290                 295                 300                 


Asp Trp Ala Ala Leu Lys Leu His Gly Lys Cys Asp Asp Val Met Arg 
305                 310                 315                 320 


Leu Leu Met Ala Glu Leu Gly Leu Glu Ile Pro Ala Tyr Ser Arg Trp 
                325                 330                 335     


Gln Asp Pro Ile Phe Ser Leu Ala Thr Pro Leu Arg Ala Gly Glu Glu 
            340                 345                 350         


Gly Ser His Ser Arg Lys Ser Leu Cys Arg Ser Arg Glu Glu Ala Pro 
        355                 360                 365             


Pro Gly Asp Arg Gly Ala Pro Leu Ser Ser Ala Pro Ile Leu Gly Gly 
    370                 375                 380                 


Trp Phe Gly Arg Gly Cys Thr Lys Arg Thr Lys Arg Lys Lys Val Thr 
385                 390                 395                 400 


