                         SEQUENCE LISTING

<110>  The Trustees of Columbia University in the City of New York
 
<120>  COMPOSITIONS AND METHODS FOR TARGETED PROTEIN STABILIZATION BY 
       REDIRECTING ENDOGENOUS DEUBIQUITINASES

<130>  1035795.000597

<160>  81    

<170>  PatentIn version 3.5

<210>  1
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  1

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Phe Ala Thr Tyr 
            20                  25                  30          


Tyr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ala Tyr Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Glu Gln Tyr Glu Gln Tyr Arg Thr Leu Pro Pro Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  2
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  2

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Phe Gly Ile Val 
            20                  25                  30          


Tyr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Asp Thr Gly Thr Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Glu Gly Arg Asp Tyr Arg Asp Tyr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  3
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  3

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Ser Asp Thr Arg 
            20                  25                  30          


Tyr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Asp Tyr Gly Ser Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Glu Tyr Val Leu Ser Lys Asp His Glu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  4
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  4

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Glu Arg Ala 
            20                  25                  30          


Tyr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Gly Tyr Gly Thr Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Leu Ala Arg Asp Val Tyr Ser Tyr Asn Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  5
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  5

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Phe Ser Phe Ser 
            20                  25                  30          


Tyr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ala Arg Gly Thr Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Glu His Asn Trp Gly Glu Pro Tyr Arg Ser Tyr Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  6
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  6

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Ser Asp Tyr Leu 
            20                  25                  30          


Arg Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Ala Arg Gly Gly Ile Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Leu Pro Tyr Tyr Lys Tyr Asn Gly Phe Val Leu Val Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  7

Gly Thr Ile Phe Ala Thr Tyr Tyr Met 
1               5                   


<210>  8
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  8

Glu Leu Val Ala Ala Ile Ala Tyr Gly Gly Thr Thr Tyr Tyr 
1               5                   10                  


<210>  9
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  9

Ala Ala Glu Gln Tyr Glu Gln Tyr Arg Thr Leu Pro Pro Tyr Asp Tyr 
1               5                   10                  15      


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  10

Gly Tyr Ile Phe Gly Ile Val Tyr Met 
1               5                   


<210>  11
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  11

Glu Leu Val Ala Thr Ile Asp Thr Gly Thr Asn Thr Tyr Tyr 
1               5                   10                  


<210>  12
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  12

Ala Ala Glu Gly Arg Asp Tyr Arg Asp Tyr Asp Tyr 
1               5                   10          


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  13

Gly Thr Ile Ser Asp Thr Arg Tyr Met 
1               5                   


<210>  14
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  14

Glu Leu Val Ala Ala Ile Asp Tyr Gly Ser Thr Thr Tyr Tyr 
1               5                   10                  


<210>  15
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  15

Ala Ala Glu Tyr Val Leu Ser Lys Asp His Glu Tyr 
1               5                   10          


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  16

Gly Ser Ile Phe Glu Arg Ala Tyr Met 
1               5                   


<210>  17
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  17

Glu Phe Val Ala Ala Ile Gly Tyr Gly Thr Asn Thr Asn Tyr 
1               5                   10                  


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  18

Ala Ala Leu Ala Arg Asp Val Tyr Ser Tyr Asn Tyr 
1               5                   10          


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  19

Gly Thr Ile Phe Ser Phe Ser Tyr Met 
1               5                   


<210>  20
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  20

Glu Leu Val Ala Ala Ile Ala Arg Gly Thr Thr Thr Tyr Tyr 
1               5                   10                  


<210>  21
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  21

Ala Ala Glu His Asn Trp Gly Glu Pro Tyr Arg Ser Tyr Tyr Asp Tyr 
1               5                   10                  15      


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  22

Gly Tyr Ile Ser Asp Tyr Leu Arg Met 
1               5                   


<210>  23
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  23

Glu Leu Val Ala Thr Ile Ala Arg Gly Gly Ile Thr Asn Tyr 
1               5                   10                  


<210>  24
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  24

Ala Ala Arg Leu Pro Tyr Tyr Lys Tyr Asn Gly Phe Val Leu Val Tyr 
1               5                   10                  15      


<210>  25
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  25

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Ser Gly Ser Gly 
            20                  25                  30          


Ser Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asn Val Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Val Arg Phe Gly Tyr Tyr Tyr Arg His Thr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  26
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  26

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Arg Phe 
            20                  25                  30          


Tyr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Ser Ala Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Val Val Ala Gly Arg Leu Leu Arg Tyr Arg Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  27
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  27

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Ser Tyr His Gly 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ala Arg Gly Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Leu Leu Arg Arg Ser Gly Tyr Ile Thr Ser Ser Phe Leu Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  28
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  28

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Ser Arg Tyr Thr 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Thr Pro Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Asp Tyr Trp Ala Lys Leu Ser Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  29
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  29

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Arg Thr 
            20                  25                  30          


Ser Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Thr Trp Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Val Leu Val Pro Ile Gly Arg Asp Val Lys Gly Tyr His Arg Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  30
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  30

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Phe Arg Tyr Ala 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asn Ser Gly Thr Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Leu Tyr Arg Asn Pro Ala Phe Pro Ile Tyr Ala His Thr Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  31
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  31

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Phe Ser Tyr Gly 
            20                  25                  30          


Tyr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Ser Arg Gly Ala Thr Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Val Val Gly Leu Arg Val Gln Tyr Gln Ala Tyr Leu Tyr Arg Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  32
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  32

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Arg Phe Gly 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ala Ser Gly Thr Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Glu Tyr Gly Tyr Gly Gly His Leu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  33
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  33

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Tyr Tyr Ser 
            20                  25                  30          


Arg Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Gly Arg Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Val 
                85                  90                  95      


Tyr Pro Asn Tyr Gln Trp Ala Tyr Ala Val Leu His Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  34
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  34

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Tyr Tyr Leu 
            20                  25                  30          


Tyr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asn Arg Gly Ala Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Val Arg Ala Ile Gln Thr Ser Ser Glu Arg Arg Tyr Phe Thr Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  35
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  35

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Ser Leu Ala Arg 
            20                  25                  30          


Tyr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Thr Tyr Gly Thr Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Tyr Leu Arg Ser Thr Thr Ser Gly Tyr Leu Tyr His Arg Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  36
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  36

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Val Ser Tyr Ala Met 
            20                  25                  30          


Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala 
        35                  40                  45              


Ile Thr Leu Gly Ser Asn Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg 
    50                  55                  60                  


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Tyr 
                85                  90                  95      


Arg Arg Tyr Gly Lys Thr Leu Tyr Leu Leu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  37
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  37

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Ser Ser Asp Ala 
            20                  25                  30          


Trp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Gly Ala Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Pro Arg Arg Arg Gly Tyr Tyr Thr Tyr Tyr Phe Arg Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  38
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  38

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Phe Gln Tyr Ala 
            20                  25                  30          


Ser Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Ser Ala Gly Ala Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Trp Tyr Asp Leu Ser Gln Tyr Pro Arg Arg His His Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  39

Gly Thr Ile Ser Gly Ser Gly Ser Met 
1               5                   


<210>  40
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  40

Glu Phe Val Ala Ala Ile Asn Val Gly Ser Asn Thr Tyr Tyr 
1               5                   10                  


<210>  41
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  41

Ala Val Arg Phe Gly Tyr Tyr Tyr Arg His Thr Tyr 
1               5                   10          


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  42

Gly Ser Ile Phe Ser Arg Phe Tyr Met 
1               5                   


<210>  43
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  43

Glu Phe Val Ala Gly Ile Ser Ala Gly Gly Thr Thr Tyr Tyr 
1               5                   10                  


<210>  44
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  44

Ala Val Val Ala Gly Arg Leu Leu Arg Tyr Arg Tyr 
1               5                   10          


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  45

Gly Thr Ile Ser Tyr His Gly Thr Met 
1               5                   


<210>  46
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  46

Glu Phe Val Ala Ala Ile Ala Arg Gly Gly Asn Thr Asn Tyr 
1               5                   10                  


<210>  47
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  47

Ala Ala Leu Leu Arg Arg Ser Gly Tyr Ile Thr Ser Ser Phe Leu Tyr 
1               5                   10                  15      


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  48

Gly Thr Ile Ser Arg Tyr Thr Thr Met 
1               5                   


<210>  49
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  49

Glu Leu Val Ala Gly Ile Thr Pro Gly Gly Ser Thr Tyr Tyr 
1               5                   10                  


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  50

Ala Ala Arg Asp Tyr Trp Ala Lys Leu Ser Tyr 
1               5                   10      


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  51

Gly Ser Ile Phe Ser Arg Thr Ser Met 
1               5                   


<210>  52
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  52

Glu Leu Val Ala Gly Ile Thr Trp Gly Gly Asn Thr Tyr Tyr 
1               5                   10                  


<210>  53
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  53

Ala Val Leu Val Pro Ile Gly Arg Asp Val Lys Gly Tyr His Arg Tyr 
1               5                   10                  15      


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  54

Gly Thr Ile Phe Arg Tyr Ala Val Met 
1               5                   


<210>  55
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  55

Glu Phe Val Ala Ala Ile Asn Ser Gly Thr Asn Thr Asn Tyr 
1               5                   10                  


<210>  56
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  56

Ala Ala Leu Tyr Arg Asn Pro Ala Phe Pro Ile Tyr Ala His Thr Tyr 
1               5                   10                  15      


<210>  57
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  57

Gly Thr Ile Phe Ser Tyr Gly Tyr Met Gly 
1               5                   10  


<210>  58
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  58

Glu Phe Val Ala Gly Ile Ser Arg Gly Ala Thr Thr Asn Tyr 
1               5                   10                  


<210>  59
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  59

Ala Val Val Gly Leu Arg Val Gln Tyr Gln Ala Tyr Leu Tyr Arg Tyr 
1               5                   10                  15      


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  60

Gly Ser Ile Ser Arg Phe Gly Val Met 
1               5                   


<210>  61
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  61

Glu Phe Val Ala Ala Ile Ala Ser Gly Thr Thr Thr Tyr Tyr 
1               5                   10                  


<210>  62
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  62

Ala Ala Arg Glu Tyr Gly Tyr Gly Gly His Leu Tyr 
1               5                   10          


<210>  63
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  63

Gly Ser Ile Phe Tyr Tyr Ser Arg Met 
1               5                   


<210>  64
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  64

Glu Leu Val Ala Gly Ile Gly Arg Gly Thr Thr Tyr Tyr 
1               5                   10              


<210>  65
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  65

Ala Val Tyr Pro Asn Tyr Gln Trp Ala Tyr Ala Val Leu His Gly Tyr 
1               5                   10                  15      


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  66

Gly Ser Ile Ser Tyr Tyr Leu Tyr Met 
1               5                   


<210>  67
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  67

Glu Phe Val Ala Ala Ile Asn Arg Gly Ala Thr Thr Tyr Tyr 
1               5                   10                  


<210>  68
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  68

Ala Val Arg Ala Ile Gln Thr Ser Ser Glu Arg Arg Tyr Phe Thr Tyr 
1               5                   10                  15      


<210>  69
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  69

Gly Thr Ile Ser Leu Ala Arg Tyr Met 
1               5                   


<210>  70
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  70

Glu Phe Val Ala Gly Ile Thr Tyr Gly Thr Thr Thr Tyr Tyr 
1               5                   10                  


<210>  71
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  71

Ala Ala Tyr Leu Arg Ser Thr Thr Ser Gly Tyr Leu Tyr His Arg Tyr 
1               5                   10                  15      


<210>  72
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  72

Gly Thr Val Ser Tyr Ala Met 
1               5           


<210>  73
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  73

Glu Phe Val Ala Ala Ile Thr Leu Gly Ser Asn Thr Asn Tyr 
1               5                   10                  


<210>  74
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  74

Ala Ala Tyr Arg Arg Tyr Gly Lys Thr Leu Tyr Leu Leu Tyr 
1               5                   10                  


<210>  75
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  75

Gly Thr Ile Ser Ser Asp Ala Trp Met 
1               5                   


<210>  76
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  76

Glu Leu Val Ala Ser Ile Ser Thr Gly Ala Thr Thr Tyr Tyr 
1               5                   10                  


<210>  77
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  77

Ala Ala Val Pro Arg Arg Arg Gly Tyr Tyr Thr Tyr Tyr Phe Arg Tyr 
1               5                   10                  15      


<210>  78
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  78

Gly Tyr Ile Phe Gln Tyr Ala Ser Met 
1               5                   


<210>  79
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  79

Glu Leu Val Ala Gly Ile Ser Ala Gly Ala Thr Thr Tyr Tyr 
1               5                   10                  


<210>  80
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  80

Ala Ala Arg Trp Tyr Asp Leu Ser Gln Tyr Pro Arg Arg His His Tyr 
1               5                   10                  15      


<210>  81
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bungarotoxin-binding site

<400>  81
tggcggtact acgagagcag cctggagccc taccccgac                              39


