                         SEQUENCE LISTING

<110>  Aptevo Research and Development LLC
       Clapper, Jonathan
       Wee, Siowfong
       Li, Gang
 
<120>  METHODS AND COMPOSITIONS FOR PREVENTING ADSORPTION OF THERAPEUTIC
        PROTEINS TO DRUG DELIVERY SYSTEM COMPONENTS

<130>  APVO-060/01WO

<150>  US 62/960,602
<151>  2020-01-13

<160>  389   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD86 HCDR1

<400>  1

Asp Tyr Asn Met Asn 
1               5   


<210>  2
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD86 HCDR2

<400>  2

Ile Asp Pro Tyr Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys Gly 
1               5                   10                  15      


<210>  3
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD86 HCDR3

<400>  3

Trp Asp Tyr Arg Tyr Asp Asp Gly Arg Ala Tyr Tyr Val Met Asp Phe 
1               5                   10                  15      


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD86 LCDR1

<400>  4

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD86 LCDR2

<400>  5

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD86 LCDR3

<400>  6

His Gln Tyr Leu Tyr Ser Trp Thr 
1               5               


<210>  7
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  humanized anti-CD86 VH

<400>  7

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Tyr Arg Tyr Asp Asp Gly Arg Ala Tyr Tyr Val Met 
            100                 105                 110         


Asp Phe Trp Gly Gln Gly Thr Thr Val Thr Val 
        115                 120             


<210>  8
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  humanized anti-CD86 VL

<400>  8

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Tyr Ser Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Leu 
        


<210>  9
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  humanized anti-CD86 scFv

<400>  9

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Tyr Arg Tyr Asp Asp Gly Arg Ala Tyr Tyr Val Met 
            100                 105                 110         


Asp Phe Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu 
145                 150                 155                 160 


Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr 
                165                 170                 175     


Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
            180                 185                 190         


Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly 
        195                 200                 205             


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 


Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His 
225                 230                 235                 240 


Gln Tyr Leu Tyr Ser Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
                245                 250                 255     


Lys Arg Leu 
            


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD123 HCDR1

<400>  10

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD123 HCDR2

<400>  11

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD123 HCDR3

<400>  12

Ala Lys Glu Lys Leu Arg Tyr Phe Asp Trp Leu Ser Asp Ala Phe Asp 
1               5                   10                  15      


Ile 
    


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD123 LCDR1

<400>  13

His Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr 
1               5                   10          


<210>  14
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD123 LCDR2

<400>  14

Trp Ala Ser 
1           


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD123 LCDR3

<400>  15

Gln Gln Tyr Tyr Ser Thr Pro Pro Thr Thr 
1               5                   10  


<210>  16
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ANTI-CD123 VH

<400>  16

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser His Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Pro Thr Thr Phe Gly Gly Gly Thr Lys Val Glu 
            100                 105                 110         


Ile Lys 
        


<210>  17
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ANTI-CD123 VL

<400>  17

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Lys Leu Arg Tyr Phe Asp Trp Leu Ser Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  18
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD123 scFv

<400>  18

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser His Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Pro Thr Thr Phe Gly Gly Gly Thr Lys Val Glu 
            100                 105                 110         


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Phe Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Gly Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr 
            180                 185                 190         


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Lys Glu Lys Leu Arg Tyr Phe Asp Trp 
225                 230                 235                 240 


Leu Ser Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val 
                245                 250                 255     


Ser Ser 
        


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3? HCDR1

<400>  19

Gly Tyr Thr Phe Ser Arg Ser Thr 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3? HCDR2

<400>  20

Ile Asn Pro Ser Ser Ala Tyr Thr 
1               5               


<210>  21
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3? HCDR3

<400>  21

Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr 
1               5                   10                  


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3? LCDR1

<400>  22

Ala Ser Ser Ser Val Ser Tyr 
1               5           


<210>  23
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3? LCDR2

<400>  23

Asp Ser Ser 
1           


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3? LCDR3

<400>  24

Gln Gln Trp Ser Arg Asn Pro Pro Thr 
1               5                   


<210>  25
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3? VH

<400>  25

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  26
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3? VL

<400>  26

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser 
            100                 105             


<210>  27
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3? scFv

<400>  27

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser 
            180                 185                 190         


Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Ser 
                245                 


<210>  28
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Monomeric IL-10

<400>  28

Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro 
1               5                   10                  15      


Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg 
            20                  25                  30          


Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu 
        35                  40                  45              


Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala 
65                  70                  75                  80  


Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu 
                85                  90                  95      


Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                 105                 110         


Pro Cys Glu Asn Gly Gly Gly Ser Gly Gly Lys Ser Lys Ala Val Glu 
        115                 120                 125             


Gln Val Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys 
    130                 135                 140                 


Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met 
145                 150                 155                 160 


Thr Met Lys Ile Arg Asn 
                165     


<210>  29
<211>  2112
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  anti-CD86 x monomeric IL-10 bispecific construct DNA sequence

<400>  29
aagcttgccg ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca       60

gataccaccg gtcaggtgca gctggtgcag tctggggctg aggtgaagaa gcctggggcc      120

tcagtgaagg tctcctgcaa ggcttctgga tacaccttca ccgactacaa catgaactgg      180

gtgcgacagg cccctggaca agggcttgag tggatgggaa atattgatcc ttactatggt      240

ggtactagtt acaatcagaa gttcaagggc agggtcacca tgaccaggga cacgtccatc      300

agcacagcct acatggagct gagcaggctg agatctgacg acacggccgt gtattactgt      360

gcgagatggg actataggta cgacgacggg agggcttact atgttatgga cttctggggc      420

caagggacca cggtcaccgt ctcctcaggt ggaggcggtt caggcggagg tggatccggc      480

ggtggcggat cgggtggcgg cggatctgac atcgtgatga cccagtctcc agactccctg      540

gctgtgtctc tgggcgagag ggccaccatc aactgcaagt ccagccagag tgttttatac      600

agctccaacc agaagaacta cttagcttgg taccagcaga aaccaggaca gcctcctaag      660

ctgctcattt actgggcatc tacccgggaa tccggggtcc ctgaccgatt cagtggcagc      720

gggtctggga cagatttcac tctcaccatc agcagcctgc aggctgaaga tgtggcagtt      780

tattactgtc atcaatacct ctactcgtgg acgtttggcc aggggaccaa gctggagatc      840

aaacggctcg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      900

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      960

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag     1020

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1080

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1140

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1200

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1260

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1320

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1380

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1440

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1500

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gttcttccct gaatacagga     1560

actcagccga attctagccc aggccagggc acccagtctg agaacagctg cacccacttc     1620

ccaggcaacc tgcctaacat gcttcgagat ctccgagatg ccttcagcag agtgaagact     1680

ttctttcaaa tgaaggatca gctggacaac ttgttgttaa aggagtcctt gctggaggac     1740

tttaagggtt acctgggttg ccaagccttg tctgagatga tccagtttta cctggaggag     1800

gtgatgcccc aagctgagaa ccaagaccca gacatcaagg cgcatgtgaa ctccctgggg     1860

gagaacctga agaccctcag gctgaggcta cggcgctgtc atcgatttct tccctgtgaa     1920

aacggtggtg gatccggcgg taagagcaag gccgtggagc aggtgaagaa tgcctttaat     1980

aagctccaag agaaaggcat ctacaaagcc atgagtgagt ttgacatctt catcaactac     2040

atagaagcct acatgacaat gaagatacga aactaacgta cgttcgaacc cgggcacgtg     2100

cggaccgaat tc                                                         2112


<210>  30
<211>  667
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD86 x monomeric IL-10 bispecific construct amino acid sequence

<400>  30

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Tyr Arg Tyr Asp Asp Gly Arg Ala Tyr Tyr Val Met 
            100                 105                 110         


Asp Phe Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu 
145                 150                 155                 160 


Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr 
                165                 170                 175     


Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
            180                 185                 190         


Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly 
        195                 200                 205             


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 


Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His 
225                 230                 235                 240 


Gln Tyr Leu Tyr Ser Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
                245                 250                 255     


Lys Arg Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
        275                 280                 285             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    290                 295                 300                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
305                 310                 315                 320 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                325                 330                 335     


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            340                 345                 350         


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
        355                 360                 365             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    370                 375                 380                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
385                 390                 395                 400 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                405                 410                 415     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            420                 425                 430         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        435                 440                 445             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    450                 455                 460                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
465                 470                 475                 480 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Ser Leu Asn Thr Gly 
                485                 490                 495     


Thr Gln Pro Asn Ser Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser 
            500                 505                 510         


Cys Thr His Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg 
        515                 520                 525             


Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu 
    530                 535                 540                 


Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr 
545                 550                 555                 560 


Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu 
                565                 570                 575     


Val Met Pro Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val 
            580                 585                 590         


Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg 
        595                 600                 605             


Cys His Arg Phe Leu Pro Cys Glu Asn Gly Gly Gly Ser Gly Gly Lys 
    610                 615                 620                 


Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe Asn Lys Leu Gln Glu 
625                 630                 635                 640 


Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr 
                645                 650                 655     


Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn 
            660                 665         


<210>  31
<211>  777
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD123 x anti-CD3? bispecific construct amino acid sequence

<400>  31

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser His Ser 
        35                  40                  45              


Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Pro Thr Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Gly Leu Glu Gly Val Ser Ala Ile Ser Gly Ser 
        195                 200                 205             


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Glu Lys Leu Arg 
                245                 250                 255     


Tyr Phe Asp Trp Leu Ser Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            260                 265                 270         


Met Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
        275                 280                 285             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val 
    290                 295                 300                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
305                 310                 315                 320 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                325                 330                 335     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            340                 345                 350         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        355                 360                 365             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    370                 375                 380                 


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
385                 390                 395                 400 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                405                 410                 415     


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            420                 425                 430         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        435                 440                 445             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    450                 455                 460                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
465                 470                 475                 480 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                485                 490                 495     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Gly 
            500                 505                 510         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Ser 
        515                 520                 525             


Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser 
    530                 535                 540                 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser 
545                 550                 555                 560 


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
                565                 570                 575     


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
            580                 585                 590         


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
        595                 600                 605             


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
    610                 615                 620                 


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
625                 630                 635                 640 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                645                 650                 655     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
            660                 665                 670         


Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val 
        675                 680                 685             


Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
    690                 695                 700                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser 
705                 710                 715                 720 


Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                725                 730                 735     


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
            740                 745                 750         


Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly 
        755                 760                 765             


Gly Thr Lys Val Glu Ile Lys Arg Ser 
    770                 775         


<210>  32
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  modified immunoglobulin constant region

<400>  32
tcgagtgagc ccaaatcttc tgacaaaact cacacatgcc caccgtgccc agcacctgaa       60

gccgcgggtg caccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      120

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      180

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      240

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      300

ctgaatggca aggaatacaa gtgcgcggtc tccaacaaag ccctcccagc ccccatcgag      360

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca      420

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat      480

ccaagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc      540

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac      600

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac      660

aaccactaca cgcagaagag cctctccctg tctccgggt                             699


<210>  33
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  modified immunoglobulin constant region

<400>  33

Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
            20                  25                  30          


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        35                  40                  45              


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    50                  55                  60                  


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
65                  70                  75                  80  


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                85                  90                  95      


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn 
            100                 105                 110         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        115                 120                 125             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    130                 135                 140                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
145                 150                 155                 160 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                165                 170                 175     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            180                 185                 190         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        195                 200                 205             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    210                 215                 220                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230             


<210>  34
<211>  693
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  modified immunoglobulin constant region

<400>  34
gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg       60

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggaat acaagtgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc cctgtctccg ggt                                   693


<210>  35
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  modified immunoglobulin constant region

<400>  35

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210>  36
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoglobulin hinge region

<400>  36

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Ser 
1               5                   10                  15  


<210>  37
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoglobulin hinge region

<400>  37

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  38
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoglobulin hinge region

<400>  38

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  39
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoglobulin hinge region

<400>  39

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Ser 
1               5                   10                  15  


<210>  40
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoglobulin hinge region

<400>  40

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Ser 
1               5                   10                  15  


<210>  41
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoglobulin hinge region

<400>  41

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Ser 
1               5                   10                  15  


<210>  42
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoglobulin hinge region

<400>  42

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  43
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoglobulin hinge region

<400>  43

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  44
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoglobulin hinge region

<400>  44

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  45
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoglobulin hinge region

<400>  45

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  46
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoglobulin hinge region

<400>  46

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  47
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoglobulin hinge region

<400>  47

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  48
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoglobulin hinge region

<400>  48

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  49
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  immunoglobulin hinge region

<400>  49

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Pro 
1               5                   10                  15  


<210>  50
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  50

Ser Cys Pro Pro Cys Pro 
1               5       


<210>  51
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  51

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Asn Ser 
            20  


<210>  52
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  52

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Asn Ser 
        35              


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  53

Gly Gly Gly Gly Ser Gly Asn Ser 
1               5               


<210>  54
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  54

Asn Tyr Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10  


<210>  55
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  55

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10              


<210>  56
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  56

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10                  15  


<210>  57
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  57

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Asn Ser 
        


<210>  58
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  58

Gly Cys Pro Pro Cys Pro Asn Ser 
1               5               


<210>  59
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  59

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  60
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  60

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  61
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  61

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  62
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  62

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  63
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  63

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  64
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  64

Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser 
1               5                   10                  15      


<210>  65
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  65

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly 
1               5                   10                  15      


His Ser 
        


<210>  66
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  66

Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Ser Pro Asn Ser 
1               5                   10                  


<210>  67
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  67

Asn Ser Leu Ala Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
1               5                   10                  15      


Ser Pro Asn Ser 
            20  


<210>  68
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  68

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Pro Asn Ser 
            


<210>  69
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  69

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Pro Gly Ser 
            


<210>  70
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  70

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro 
1               5                   10                  15      


Ser 
    


<210>  71
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  71

Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 
1               5                   10                  15  


<210>  72
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  72

Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Ser Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  73
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  73

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser 
1               5                   10                  15  


<210>  74
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  74

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Ser Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  75
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  75

Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser Asn Ser 
1               5                   10                  15  


<210>  76
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  76

Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  77
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  77

Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His Ile Gln Asn Ser 
1               5                   10                  15  


<210>  78
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  78

Leu Asp Val Ser Glu Arg Pro Phe Pro Pro His Ile Gln Ser Cys Pro 
1               5                   10                  15      


Pro Cys Pro Asn Ser 
            20      


<210>  79
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  79

Arg Glu Gln Leu Ala Glu Val Thr Leu Ser Leu Lys Ala Asn Ser 
1               5                   10                  15  


<210>  80
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  80

Arg Glu Gln Leu Ala Glu Val Thr Leu Ser Leu Lys Ala Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  81
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  81

Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser 
1               5                   10                  15  


<210>  82
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  82

Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  83
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  83

Asp Thr Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Ser Asn Ser 
1               5                   10                  15  


<210>  84
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  84

Leu Pro Pro Glu Thr Gln Glu Ser Gln Glu Val Thr Leu Asn Ser 
1               5                   10                  15  


<210>  85
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  85

Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro Asn Ser 
1               5                   10                  15  


<210>  86
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  86

Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  87
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  87

Gly Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Asn Ser 
1               5                   10              


<210>  88
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  88

Gly Cys Pro Pro Cys Pro Ala Asn Ser 
1               5                   


<210>  89
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  89

Gly Cys Pro Pro Cys Pro Ala Asn Ser 
1               5                   


<210>  90
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  90

Gly Cys Pro Pro Cys Pro Asn Ser 
1               5               


<210>  91
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  91

Gly Gly Gly Ala Ser Cys Pro Pro Cys Pro Gly Asn Ser 
1               5                   10              


<210>  92
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  92

Gly Gly Gly Ala Ser Cys Pro Pro Cys Ala Gly Asn Ser 
1               5                   10              


<210>  93
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  93

Gly Gly Gly Ala Ser Cys Pro Pro Cys Ala Asn Ser 
1               5                   10          


<210>  94
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  94

Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 
1               5                   10                  15  


<210>  95
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  95

Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 
1               5                   10      


<210>  96
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  96

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser 
1               5                   10                  15  


<210>  97
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  97

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser 
1               5                   10                  15  


<210>  98
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  98

Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ser 
1               5                   10      


<210>  99
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  99

Ser Gln Pro Glu Ile Val Pro Ile Ser Cys Pro Pro Cys Pro Asn Ser 
1               5                   10                  15      


<210>  100
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  100

Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Ser Cys Pro Pro Cys 
1               5                   10                  15      


Pro Asn Ser 
            


<210>  101
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  101

Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser 
1               5                   10                  15  


<210>  102
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  102

Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser 
1               5                   10          


<210>  103
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  103

Val Ser Glu Arg Pro Phe Pro Pro Asn Ser 
1               5                   10  


<210>  104
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  104

Lys Pro Phe Phe Thr Cys Gly Ser Ala Asp Thr Cys Pro Asn Ser 
1               5                   10                  15  


<210>  105
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  105

Lys Pro Phe Phe Thr Cys Gly Ser Ala Asp Thr Cys Pro Asn Ser 
1               5                   10                  15  


<210>  106
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  106

Gln Tyr Asn Cys Pro Gly Gln Tyr Thr Phe Ser Met Pro Asn Ser 
1               5                   10                  15  


<210>  107
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  107

Glu Pro Ala Phe Thr Pro Gly Pro Asn Ile Glu Leu Gln Lys Asp Ser 
1               5                   10                  15      


Asp Cys Pro Asn Ser 
            20      


<210>  108
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  108

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg 
1               5                   10                  15      


His Cys Pro Asn Ser 
            20      


<210>  109
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hinge or linker sequence

<400>  109

Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  110
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 LCDR1

<400>  110

Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
1               5                   10                  


<210>  111
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 LCDR1

<400>  111

Arg Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
1               5                   10                  


<210>  112
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 LCDR1

<400>  112

Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
1               5                   10                  


<210>  113
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 LCDR2

<400>  113

Gly Thr Lys Phe Leu Ala Pro 
1               5           


<210>  114
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 LCDR2

<400>  114

Ala Thr Asp Met Arg Pro Ser 
1               5           


<210>  115
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 LCDR2

<400>  115

Gly Thr Lys Phe Leu Ala Pro 
1               5           


<210>  116
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 LCDR3

<400>  116

Ala Leu Trp Tyr Ser Asn Arg Trp Val 
1               5                   


<210>  117
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 LCDR3

<400>  117

Ala Leu Trp Tyr Ser Asn Arg Trp Val 
1               5                   


<210>  118
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 LCDR3

<400>  118

Val Leu Trp Tyr Ser Asn Arg Trp Val 
1               5                   


<210>  119
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 HCDR1

<400>  119

Ile Tyr Ala Met Asn 
1               5   


<210>  120
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 HCDR1

<400>  120

Lys Tyr Ala Met Asn 
1               5   


<210>  121
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 HCDR1

<400>  121

Ser Tyr Ala Met Asn 
1               5   


<210>  122
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 HCDR2

<400>  122

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Ser 
            


<210>  123
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 HCDR2

<400>  123

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  124
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 HCDR2

<400>  124

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  125
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 HCDR3

<400>  125

His Gly Asn Phe Gly Asn Ser Tyr Val Ser Phe Phe Ala Tyr 
1               5                   10                  


<210>  126
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 HCDR3

<400>  126

His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
1               5                   10                  


<210>  127
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 HCDR3

<400>  127

His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Phe Trp Ala Tyr 
1               5                   10                  


<210>  128
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide linker

<400>  128

Gly Gly Gly Gly Ser 
1               5   


<210>  129
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide linker


<220>
<221>  MISC_FEATURE
<222>  (6)..(10)
<223>  may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (21)..(25)
<223>  may be present or absent

<400>  129

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  130
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DE loop insertion peptide

<400>  130

Gly Gly Gly Ser Gly Gly 
1               5       


<210>  131
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Modified immunoglobulin constant region

<400>  131

Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215     


<210>  132
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fc binding domain linker

<400>  132

Ser Ser Leu Asn Thr Gly Thr Gln Pro Asn Ser 
1               5                   10      


<210>  133
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  OMT1 variable light chain domain

<400>  133
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca cagtgtttta tacagctcca acaataagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttatagtact      300

cctccgacca ctttcggcgg agggaccaag gtggagatca aa                         342


<210>  134
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OMT1 variable light chain domain

<400>  134

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser His Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Pro Thr Thr Phe Gly Gly Gly Thr Lys Val Glu 
            100                 105                 110         


Ile Lys 
        


<210>  135
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  OMT1 variable heavy chain domain

<400>  135
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatggca tgagctgggt ccgccaggct      120

ccagggaagg ggctggaggg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagaaaag      300

ttacgatatt ttgactggtt atccgatgct tttgatatct ggggccaagg gacaatggtc      360

accgtctctt ca                                                          372


<210>  136
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OMT1 variable heavy chain domain

<400>  136

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Lys Leu Arg Tyr Phe Asp Trp Leu Ser Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  137
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  OMT1 CDRL1

<400>  137
cacagtgttt tatacagctc caacaataag aactac                                 36


<210>  138
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OMT1 CDRL1

<400>  138

His Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr 
1               5                   10          


<210>  139
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OMT1 CDRL2

<400>  139

Thr Gly Gly Gly Cys Ala Thr Cys Thr 
1               5                   


<210>  140
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OMT1 CDRL2

<400>  140

Trp Ala Ser 
1           


<210>  141
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  OMT1 CDRL3

<400>  141
cagcaatatt atagtactcc tccgaccact                                        30


<210>  142
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OMT1 CDRL3

<400>  142

Gln Gln Tyr Tyr Ser Thr Pro Pro Thr Thr 
1               5                   10  


<210>  143
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  OMT1 CDRH1

<400>  143
ggattcacct ttagcagcta tggc                                              24


<210>  144
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OMT1 CDRH1

<400>  144

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  145
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  OMT1 CDRH2

<400>  145
attagtggta gtggtggtag caca                                              24


<210>  146
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OMT1 CDRH2

<400>  146

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  147
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  OMT1 CDRH3

<400>  147
gcgaaagaaa agttacgata ttttgactgg ttatccgatg cttttgatat c                51


<210>  148
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OMT1 CDRH3

<400>  148

Ala Lys Glu Lys Leu Arg Tyr Phe Asp Trp Leu Ser Asp Ala Phe Asp 
1               5                   10                  15      


Ile 
    


<210>  149
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB8 variable light chain domain

<400>  149
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatctga attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcgga      300

ggtaccaagg tggagatcaa a                                                321


<210>  150
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB8 variable light chain domain

<400>  150

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  151
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB8 variable heavychain domain

<400>  151
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata catcttcacc gactactata tgcactgggt gcgtcaggcc      120

cctggacaag ggcttgagtg gatgggatgg atgagcccta acagtggtaa cacaggctat      180

gcacagaagt tccagggccg tgtcaccatg acccgcgaca cgtccacgag cacagtctac      240

atggagctga gcagcctgcg ttctgaggac acggccgtgt attactgtgc gagagatgcg      300

gcggattacg gtgactacgt tgcttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcttca                                                                 366


<210>  152
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB8 variable heavy chain domain

<400>  152

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Ser Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Ala Asp Tyr Gly Asp Tyr Val Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  153
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB8 CDR L1

<400>  153
cagagcatta gcagctat                                                     18


<210>  154
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB8 CDR L1

<400>  154

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  155
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB8 CDR L2

<400>  155
gctgcatcc                                                                9


<210>  156
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB8 CDR L2

<400>  156

Ala Ala Ser 
1           


<210>  157
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB8 CDR L3

<400>  157
caacagagtt acagtacccc tctcact                                           27


<210>  158
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB8 CDR L3

<400>  158

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  159
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB8 CDR H1

<400>  159
ggatacatct tcaccgacta ctat                                              24


<210>  160
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB8 CDR H1

<400>  160

Gly Tyr Ile Phe Thr Asp Tyr Tyr 
1               5               


<210>  161
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB8 CDR H2

<400>  161
atgagcccta acagtggtaa caca                                              24


<210>  162
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB8 CDR H2

<400>  162

Met Ser Pro Asn Ser Gly Asn Thr 
1               5               


<210>  163
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB8 CDR H3

<400>  163
gcgagagatg cggcggatta cggtgactac gttgcttttg atatc                       45


<210>  164
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB8 CDR H3

<400>  164

Ala Arg Asp Ala Ala Asp Tyr Gly Asp Tyr Val Ala Phe Asp Ile 
1               5                   10                  15  


<210>  165
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB60 variable light chain domain

<400>  165
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatctga attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcgga      300

ggtaccaagg tggagatcaa a                                                321


<210>  166
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB60 variable light chain domain

<400>  166

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  167
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB60 variable heavy chain domain

<400>  167
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgtcaggcc      120

cctggacaag ggcttgagtg gatggggtgg atcaacccta acagtggtga cacaagctat      180

gcacagaagt tccagggccg tgtcaccatg acccgcgaca cgtccacgag cacagtctac      240

atggagctga gcagcctgcg ttctgaggac acggccgtgt attactgtgc gcaggatagt      300

agtggttccg gggcttttga tatctggggc caagggacaa tggtcaccgt ctcttca         357


<210>  168
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB60 variable heavy chain domain

<400>  168

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Asp Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gln Asp Ser Ser Gly Ser Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  169
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB60 CDR L1

<400>  169
cagagcatta gcagctat                                                     18


<210>  170
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB60 CDR L1

<400>  170

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  171
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB60 CDR L2

<400>  171
gctgcatcc                                                                9


<210>  172
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB60 CDR L2

<400>  172

Ala Ala Ser 
1           


<210>  173
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB60 CDR L3

<400>  173
caacagagtt acagtacccc tctcact                                           27


<210>  174
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB60 CDR L3

<400>  174

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  175
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB60 CDR H1

<400>  175
ggatacacct tcaccagcta ctat                                              24


<210>  176
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB60 CDR H1

<400>  176

Gly Tyr Thr Phe Thr Ser Tyr Tyr 
1               5               


<210>  177
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB60 CDR H2

<400>  177
atcaacccta acagtggtga caca                                              24


<210>  178
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB60 CDR H2

<400>  178

Ile Asn Pro Asn Ser Gly Asp Thr 
1               5               


<210>  179
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB60 CDR H3

<400>  179
gcgcaggata gtagtggttc cggggctttt gatatc                                 36


<210>  180
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB60 CDR H3

<400>  180

Ala Gln Asp Ser Ser Gly Ser Gly Ala Phe Asp Ile 
1               5                   10          


<210>  181
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB65 variable light chain domain

<400>  181
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatctga attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcgga      300

ggtaccaagg tggagatcaa a                                                321


<210>  182
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB65 variable light chain domain

<400>  182

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  183
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB65 variable heavy chain domain

<400>  183
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc ggctactata tgcactgggt gcgtcaggcc      120

cctggacaag ggcttgagtg gatgggatgg atgaacccta acagtggtaa cacaggctat      180

gcacagaagt tccagggccg tgtcaccatg acccgcgaca cgtccacgag cacagtctac      240

atggagctga gcagcctgcg ttctgaggac acggccgtgt attactgtgc gaaagaggaa      300

ccgatttttg gagtggttat ggatgctttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210>  184
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB65 variable heavy chain domain

<400>  184

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Glu Pro Ile Phe Gly Val Val Met Asp Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  185
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB65 CDR L1

<400>  185
cagagcatta gcagctat                                                     18


<210>  186
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB65 CDR L1

<400>  186

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  187
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB65 CDR L2

<400>  187
gctgcatcc                                                                9


<210>  188
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB65 CDR L2

<400>  188

Ala Ala Ser 
1           


<210>  189
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB65 CDR L3

<400>  189
caacagagtt acagtacccc tctcact                                           27


<210>  190
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB65 CDR L3

<400>  190

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  191
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB65 CDR H1

<400>  191
ggatacacct tcaccggcta ctat                                              24


<210>  192
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB65 CDR H1

<400>  192

Gly Tyr Thr Phe Thr Gly Tyr Tyr 
1               5               


<210>  193
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB65 CDR H2

<400>  193
atgaacccta acagtggtaa caca                                              24


<210>  194
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB65 CDR H2

<400>  194

Met Asn Pro Asn Ser Gly Asn Thr 
1               5               


<210>  195
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB65 CDR H3

<400>  195
gcgaaagagg aaccgatttt tggagtggtt atggatgctt ttgatatc                    48


<210>  196
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB65 CDR H3

<400>  196

Ala Lys Glu Glu Pro Ile Phe Gly Val Val Met Asp Ala Phe Asp Ile 
1               5                   10                  15      


<210>  197
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB82 variable light chain domain

<400>  197
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgcgtcacc       60

atcacttgcc gggcaagtca gaccataaac aactatttga actggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctattct gcatctactt tgcaaagtgg ggtcccatca      180

cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaccag agttacactt cacctctcac tttcggcgga      300

ggtaccaagg tggagatcaa a                                                321


<210>  198
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB82 variable light chain domain

<400>  198

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Ser Tyr Thr Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  199
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB82 variable heavy chain domain

<400>  199
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgcctc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt attagtgcca atagtgctgg tctaggccat      180

gcggactctg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgcg cgccgaggac acggccgtat attactgtgc gagagtgggc      300

tatagcagct cggctgatgc ttttgatatc tggggccaag ggacaatggt caccgtctcc      360

tcg                                                                    363


<210>  200
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB82 variable heavy chain domain

<400>  200

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Ala Asn Ser Ala Gly Leu Gly His Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Tyr Ser Ser Ser Ala Asp Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  201
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB82 CDR L1

<400>  201
cagaccataa acaactat                                                     18


<210>  202
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB82 CDR L1

<400>  202

Gln Thr Ile Asn Asn Tyr 
1               5       


<210>  203
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB82 CDR L2

<400>  203
tctgcatct                                                                9


<210>  204
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB82 CDR L2

<400>  204

Ser Ala Ser 
1           


<210>  205
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB82 CDR L3

<400>  205
caccagagtt acacttcacc tctcact                                           27


<210>  206
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB82 CDR L3

<400>  206

His Gln Ser Tyr Thr Ser Pro Leu Thr 
1               5                   


<210>  207
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB82 CDR H1

<400>  207
ggattcacct ttagcagcta tgcc                                              24


<210>  208
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB82 CDR H1

<400>  208

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  209
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB82 CDR H2

<400>  209
attagtgcca atagtgctgg tcta                                              24


<210>  210
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB82 CDR H2

<400>  210

Ile Ser Ala Asn Ser Ala Gly Leu 
1               5               


<210>  211
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB82 CDR H3

<400>  211
gcgagagtgg gctatagcag ctcggctgat gcttttgata tc                          42


<210>  212
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB82 CDR H3

<400>  212

Ala Arg Val Gly Tyr Ser Ser Ser Ala Asp Ala Phe Asp Ile 
1               5                   10                  


<210>  213
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB83 variable light chain domain

<400>  213
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctcctg catagtaatg gagacaacta tttggattgg      120

tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc      180

tccggggtcc ctgaccgttt cagtggcagt ggatcaggca cagattttac actgaaaatc      240

agccgtgtgg aggctgagga tgttggggtt tattactgca tgcaagctac acactggcca      300

ctcactttcg gccctggtac caaagtggat atcaaa                                336


<210>  214
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB83 variable light chain domain

<400>  214

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asp Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Thr His Trp Pro Leu Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110         


<210>  215
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB83 variable heavy chain domain

<400>  215
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcact agctatgcta tgcattgggt gcgtcaggcc      120

cctggacaag ggcttgagtg gatgggactt gttgatcctg aagatggtga aacaatatat      180

gcagagaagt tccagggccg tgtcaccatg acccgcgaca cgtccacgag cacagtctac      240

atggagctga gcagcctgcg ttctgaggac acggccgtgt attactgtgc gagacgaacg      300

tattactatg atagtagtgg ttcccgttat gcttttgata tctggggcca agggaccacg      360

gtcaccgtct cttca                                                       375


<210>  216
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB83 variable heavy chain domain

<400>  216

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Val Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Thr Tyr Tyr Tyr Asp Ser Ser Gly Ser Arg Tyr Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  217
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB83 CDR L1

<400>  217
cagagcctcc tgcatagtaa tggagacaac tat                                    33


<210>  218
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB83 CDR L1

<400>  218

Gln Ser Leu Leu His Ser Asn Gly Asp Asn Tyr 
1               5                   10      


<210>  219
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB83 CDR L2

<400>  219
ttgggttct                                                                9


<210>  220
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB83 CDR L2

<400>  220

Leu Gly Ser 
1           


<210>  221
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB83 CDR L3

<400>  221
atgcaagcta cacactggcc actcact                                           27


<210>  222
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB83 CDR L3

<400>  222

Met Gln Ala Thr His Trp Pro Leu Thr 
1               5                   


<210>  223
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB83 CDR H1

<400>  223
ggatacacct tcactagcta tgct                                              24


<210>  224
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB83 CDR H1

<400>  224

Gly Tyr Thr Phe Thr Ser Tyr Ala 
1               5               


<210>  225
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB83 CDR H2

<400>  225
gttgatcctg aagatggtga aaca                                              24


<210>  226
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB83 CDR H2

<400>  226

Val Asp Pro Glu Asp Gly Glu Thr 
1               5               


<210>  227
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB83 CDR H3

<400>  227
gcgagacgaa cgtattacta tgatagtagt ggttcccgtt atgcttttga tatc             54


<210>  228
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB83 CDR H3

<400>  228

Ala Arg Arg Thr Tyr Tyr Tyr Asp Ser Ser Gly Ser Arg Tyr Ala Phe 
1               5                   10                  15      


Asp Ile 
        


<210>  229
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB86 variable light chain domain

<400>  229
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgcgtcacc       60

atcacttgcc gggcaagtca gggcatcaga aatgatttag gttggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaatcagg ggtcccatca      180

cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacggtg cccccctcac tttcggcgga      300

ggtaccaagg tggagatcaa a                                                321


<210>  230
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB86 variable light chain domain

<400>  230

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Gly Ala Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  231
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB86 variable heavy chain domain

<400>  231
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata tatgttcagt ggccattctg cacactgggt gcgtcaggcc      120

cctggacaag ggcttgagtg gatgggatgg atgaacccta acagtggtaa cacaggctat      180

gcacagaagt tccagggccg tgtcaccatg acccgcgaca cgtccacgag cacagtctac      240

atggagctga gcagcctgcg ttctgaggac acggccgtgt attactgtgc gagagatagc      300

agtggctggt acgatgtctt tgactactgg ggccagggga ccctggtcac cgtctcctca      360


<210>  232
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB86 variable heavy chain domain

<400>  232

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Met Phe Ser Gly His 
            20                  25                  30          


Ser Ala His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Gly Trp Tyr Asp Val Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  233
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB86 CDR L1

<400>  233
cagggcatca gaaatgat                                                     18


<210>  234
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB86 CDR L1

<400>  234

Gln Gly Ile Arg Asn Asp 
1               5       


<210>  235
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB86 CDR L2

<400>  235
gctgcatcc                                                                9


<210>  236
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB86 CDR L2

<400>  236

Ala Ala Ser 
1           


<210>  237
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB86 CDR L3

<400>  237
caacagagtt acggtgcccc cctc                                              24


<210>  238
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB86 CDR L3

<400>  238

Gln Gln Ser Tyr Gly Ala Pro Leu Thr 
1               5                   


<210>  239
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB86 CDR H1

<400>  239
ggatatatgt tcagtggcca ttct                                              24


<210>  240
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB86 CDR H1

<400>  240

Gly Tyr Met Phe Ser Gly His Ser 
1               5               


<210>  241
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB86 CDR H2

<400>  241
atgaacccta acagtggtaa caca                                              24


<210>  242
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB86 CDR H2

<400>  242

Met Asn Pro Asn Ser Gly Asn Thr 
1               5               


<210>  243
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB86 CDR H3

<400>  243
gcgagagata gcagtggctg gtacgatgtc tttgactac                              39


<210>  244
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB86 CDR H3

<400>  244

Ala Arg Asp Ser Ser Gly Trp Tyr Asp Val Phe Asp Tyr 
1               5                   10              


<210>  245
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB280 variable light chain domain

<400>  245
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatctga attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcgga      300

ggtaccaagg tggagatcaa a                                                321


<210>  246
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB280 variable light chain domain

<400>  246

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  247
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB280 variable heavy chain domain

<400>  247
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata cagcctcaac ttatactata tgcactgggt gcgtcaggcc      120

cctggacaag ggcttgagtg gatgggatgg atgaacccta acagtggtaa cacaggctat      180

gcacagaagt tccagggccg tgtcaccatg acccgcgaca cgtccacgag cacagtctac      240

atggagctga gcagcctgcg ttctgaggac acggccgtgt attactgtgc gagcctcgat      300

tgtagtggtg gtagctgcta ctccgaatat gatgcttttg atatctgggg ccaagggacc      360

acggtcaccg tctcctca                                                    378


<210>  248
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB280 variable heavy chain domain

<400>  248

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Leu Asn Leu Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Asp Cys Ser Gly Gly Ser Cys Tyr Ser Glu Tyr Asp Ala 
            100                 105                 110         


Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  249
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB280 CDR L1

<400>  249
cagagcatta gcagctat                                                     18


<210>  250
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB280 CDR L1

<400>  250

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  251
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB280 CDR L2

<400>  251
gctgcatcc                                                                9


<210>  252
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB280 CDR L2

<400>  252

Ala Ala Ser 
1           


<210>  253
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB280 CDR L3

<400>  253
caacagagtt acagtacccc tctcact                                           27


<210>  254
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB280 CDR L3

<400>  254

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  255
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB280 CDR H1

<400>  255
ggatacagcc tcaacttata ctat                                              24


<210>  256
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB280 CDR H1

<400>  256

Gly Tyr Ser Leu Asn Leu Tyr Tyr 
1               5               


<210>  257
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB280 CDR H2

<400>  257
atgaacccta acagtggtaa caca                                              24


<210>  258
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB280 CDR H2

<400>  258

Met Asn Pro Asn Ser Gly Asn Thr 
1               5               


<210>  259
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB280 CDR H3

<400>  259
gcgagcctcg attgtagtgg tggtagctgc tactccgaat atgatgcttt tgatatc          57


<210>  260
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB280 CDR H3

<400>  260

Ala Ser Leu Asp Cys Ser Gly Gly Ser Cys Tyr Ser Glu Tyr Asp Ala 
1               5                   10                  15      


Phe Asp Ile 
            


<210>  261
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB331 variable light chain domain

<400>  261
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatctga attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcgga      300

ggtaccaagg tggagatcaa a                                                321


<210>  262
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB331 variable light chain domain

<400>  262

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  263
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB331 variable heavy chain domain

<400>  263
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgtcaggcc      120

cctggacaag ggcttgagtg gatgggatgg atgaacccta acagtggtaa cacaggctat      180

gcacagaagt tccagggccg tgtcaccatg acccgcgaca cgtccacgag cacagtctac      240

atggagctga gcagcctgcg ttctgaggac acggccgtgt attactgtgc aacagatctc      300

gcgggggaag ccttgttcga cccctggggc cagggcaccc tggtcaccgt ctcctca         357


<210>  264
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB331 variable heavy chain domain

<400>  264

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Leu Ala Gly Glu Ala Leu Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  265
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB331 CDR L1

<400>  265
cagagcatta gcagctat                                                     18


<210>  266
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB331 CDR L1

<400>  266

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  267
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB331 CDR L2

<400>  267
gctgcatcc                                                                9


<210>  268
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB331 CDR L2

<400>  268

Ala Ala Ser 
1           


<210>  269
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB331 CDR L3

<400>  269
caacagagtt acagtacccc tctcact                                           27


<210>  270
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB331 CDR L3

<400>  270

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  271
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB331 CDR H1

<400>  271
ggatacacct tcaccagcta ctat                                              24


<210>  272
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB331 CDR H1

<400>  272

Gly Tyr Thr Phe Thr Ser Tyr Tyr 
1               5               


<210>  273
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB331 CDR H2

<400>  273
atgaacccta acagtggtaa caca                                              24


<210>  274
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB331 CDR H2

<400>  274

Met Asn Pro Asn Ser Gly Asn Thr 
1               5               


<210>  275
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB331 CDR H3

<400>  275
gcaacagatc tcgcggggga agccttgttc gacccc                                 36


<210>  276
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB331 CDR H3

<400>  276

Ala Thr Asp Leu Ala Gly Glu Ala Leu Phe Asp Pro 
1               5                   10          


<210>  277
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB415 variable light chain domain

<400>  277
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatctga attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcgga      300

ggtaccaagg tggagatcaa a                                                321


<210>  278
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB415 variable light chain domain

<400>  278

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  279
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB415 variable heavy chain domain

<400>  279
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgcctc       60

tcctgtgcag cctctggaat caccttcagt agttatggca tgcattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaggt attagttgga atagtggtaa cagagtctat      180

gtggactctg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgcg cgccgaggac acggccgtat attactgtgc gagagatact      300

aatgatgctt ttgatatctg gggccaaggg accacggtca ccgtctcctc a               351


<210>  280
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB415 variable heavy chain domain

<400>  280

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Asn Arg Val Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Thr Asn Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  281
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB415 CDR L1

<400>  281
cagagcatta gcagctat                                                     18


<210>  282
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB415 CDR L1

<400>  282

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  283
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB415 CDR L2

<400>  283
gctgcatcc                                                                9


<210>  284
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB415 CDR L2

<400>  284

Ala Ala Ser 
1           


<210>  285
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB415 CDR L3

<400>  285
caacagagtt acagtacccc tctcact                                           27


<210>  286
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB415 CDR L3

<400>  286

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  287
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB415 CDR H1

<400>  287
ggaatcacct tcagtagtta tggc                                              24


<210>  288
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB415 CDR H1

<400>  288

Gly Ile Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  289
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB415 CDR H2

<400>  289
attagttgga atagtggtaa caga                                              24


<210>  290
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB415 CDR H2

<400>  290

Ile Ser Trp Asn Ser Gly Asn Arg 
1               5               


<210>  291
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB415 CDR H3

<400>  291
gcgagagata ctaatgatgc ttttgatatc                                        30


<210>  292
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB415 CDR H3

<400>  292

Ala Arg Asp Thr Asn Asp Ala Phe Asp Ile 
1               5                   10  


<210>  293
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB435 variable light chain domain

<400>  293
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatctga attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcgga      300

ggtaccaagg tggagatcaa a                                                321


<210>  294
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB435 variable light chain domain

<400>  294

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  295
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB435 variable heavy chain domain

<400>  295
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggagg caccttcagc agctatgcta tcagctgggt gcgtcaggcc      120

cctggacaag ggcttgagtg gatgggctgg atcacccctc acaatggtaa cataaagtat      180

gcacgggagt tccagggccg tgtcaccatg acccgcgaca cgtccacgag cacagtctac      240

atggagctga gcagcctgcg ttctgaggac acggccgtgt attactgtgc gaaagatctg      300

aactggaacg cagcctttga ctactggggc caggggaccc tggtcaccgt ctcctca         357


<210>  296
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB435 variable heavy chain domain

<400>  296

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Thr Pro His Asn Gly Asn Ile Lys Tyr Ala Arg Glu Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Leu Asn Trp Asn Ala Ala Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  297
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB435 CDR L1

<400>  297
cagagcatta gcagctat                                                     18


<210>  298
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB435 CDR L1

<400>  298

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  299
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB435 CDR L2

<400>  299
gctgcatcc                                                                9


<210>  300
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB435 CDR L2

<400>  300

Ala Ala Ser 
1           


<210>  301
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB435 CDR L3

<400>  301
caacagagtt acagtacccc tctcact                                           27


<210>  302
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB435 CDR L3

<400>  302

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  303
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB435 CDR H1

<400>  303
ggaggcacct tcagcagcta tgct                                              24


<210>  304
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB435 CDR H1

<400>  304

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  305
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB435 CDR H2

<400>  305
atcacccctc acaatggtaa cata                                              24


<210>  306
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB435 CDR H2

<400>  306

Ile Thr Pro His Asn Gly Asn Ile 
1               5               


<210>  307
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  DB435 CDR H3

<400>  307
gcgaaagatc tgaactggaa cgcagccttt gactac                                 36


<210>  308
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DB435 CDR H3

<400>  308

Ala Lys Asp Leu Asn Trp Asn Ala Ala Phe Asp Tyr 
1               5                   10          


<210>  309
<211>  2340
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI129

<400>  309
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc      120

tcctgtgcag cctctggatt cacctttagc agctatggca tgagctgggt ccgccaggct      180

ccagggaagg ggctggaggg ggtctcagct attagtggta gtggtggtag cacatactac      240

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      300

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagaaaag      360

ttacgatatt ttgactggtt atccgatgct tttgatatct ggggccaagg gacaatggtc      420

accgtctctt caggtggagg cggttcaggc ggaggtggat ccggcggtgg cggctccggt      480

ggcggcggat ctgacatcgt gatgacccag tctccagact ccctggctgt gtctctgggc      540

gagagggcca ccatcaactg caagtccagc cacagtgttt tatacagctc caacaataag      600

aactacttag cttggtacca gcagaaacca ggacagcctc ctaagctgct catttactgg      660

gcatctaccc gggaatccgg ggtccctgac cgattcagtg gcagcgggtc tgggacagat      720

ttcactctca ccatcagcag cctgcaggct gaagatgtgg cagtttatta ctgtcagcaa      780

tattatagta ctcctccgac cactttcggc ggagggacca aggtggagat caaatcctcg      840

agtgagccca aatcttctga caaaactcac acatgcccac cgtgcccagc acctgaagcc      900

gcgggtgcac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      960

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag     1020

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag     1080

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg     1140

aatggcaagg aatacaagtg cgcggtctcc aacaaagccc tcccagcccc catcgagaaa     1200

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1260

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatcca     1320

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1380

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1440

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1500

cactacacgc agaagagcct ctccctgtct ccgggttccg gaggaggggg ttcaggtggg     1560

ggaggttctg gcggcggggg aagcccttca caggtgcaac tggtgcagag tggacccgag     1620

gttaaaaaac cagggtcctc cgttaaggtt agctgcaaag cctctggcta cacattttcc     1680

aggagtacaa tgcactgggt gaggcaggct cctggacagg gactcgagtg gatcgggtat     1740

atcaacccat ctagcgccta taccaattac aaccaaaagt ttaaggaccg agttaccatt     1800

accgctgaca aatccaccag tacagcttat atggagctgt catctcttag gtccgaggac     1860

actgctgttt attactgcgc tcgtcctcag gttcactatg actataatgg ttttccctac     1920

tggggtcagg gaaccctggt gactgtctct tctggcggtg gaggcagcgg tgggggtggg     1980

tctggaggcg gtggcagtgg cggcggaggc tctgatattc agatgactca gtctcctagc     2040

actctcagcg ccagcgtggg ggatcgtgtg acaatgactt gctccgctag cagtagtgtg     2100

tcttacatga attggtatca gcagaagccc gggaaagcac ctaagcgctg gatctatgac     2160

tcttccaagc tggcaagtgg tgtcccctca cggttctctg gctcaggttc tggtactgac     2220

tatactttga ctatctcctc cctccagccc gatgatttcg ctacctatta ttgtcagcag     2280

tggagccgta acccacccac tttcggaggc ggtaccaaag tggagatcaa gaggtcataa     2340


<210>  310
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI129

<400>  310

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Lys Leu Arg Tyr Phe Asp Trp Leu Ser Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
145                 150                 155                 160 


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser His Ser Val Leu Tyr Ser 
                165                 170                 175     


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
225                 230                 235                 240 


Tyr Tyr Ser Thr Pro Pro Thr Thr Phe Gly Gly Gly Thr Lys Val Glu 
                245                 250                 255     


Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
            260                 265                 270         


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu 
        275                 280                 285             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    290                 295                 300                 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
305                 310                 315                 320 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                325                 330                 335     


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            340                 345                 350         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala 
        355                 360                 365             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    370                 375                 380                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
385                 390                 395                 400 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                405                 410                 415     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            420                 425                 430         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        435                 440                 445             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    450                 455                 460                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
465                 470                 475                 480 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Gly Gly Gly 
                485                 490                 495     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Ser Gln Val 
            500                 505                 510         


Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser Ser Val 
        515                 520                 525             


Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser Thr Met 
    530                 535                 540                 


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr 
545                 550                 555                 560 


Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp 
                565                 570                 575     


Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu 
            580                 585                 590         


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        595                 600                 605             


Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly 
    610                 615                 620                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
625                 630                 635                 640 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
                645                 650                 655     


Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met 
            660                 665                 670         


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln 
        675                 680                 685             


Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu 
    690                 695                 700                 


Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
705                 710                 715                 720 


Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr 
                725                 730                 735     


Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr 
            740                 745                 750         


Lys Val Glu Ile Lys Arg Ser 
        755                 


<210>  311
<211>  2334
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI130

<400>  311
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc      120

atcaactgca agtccagcca cagtgtttta tacagctcca acaataagaa ctacttagct      180

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      240

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      300

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttatagtact      360

cctccgacca ctttcggcgg agggaccaag gtggagatca aaggtggagg cggttcaggc      420

ggaggtggat ccggcggtgg cggctccggt ggcggcggat ctgaggtgca gctgttggag      480

tctgggggag gcttggtaca gcctgggggg tccctgagac tctcctgtgc agcctctgga      540

ttcaccttta gcagctatgg catgagctgg gtccgccagg ctccagggaa ggggctggag      600

ggggtctcag ctattagtgg tagtggtggt agcacatact acgcagactc cgtgaagggc      660

cggttcacca tctccagaga caattccaag aacacgctgt atctgcaaat gaacagcctg      720

agagccgagg acacggccgt atattactgt gcgaaagaaa agttacgata ttttgactgg      780

ttatccgatg cttttgatat ctggggccaa gggacaatgg tcaccgtctc ctcgagtgag      840

cccaaatctt ctgacaaaac tcacacatgc ccaccgtgcc cagcacctga agccgcgggt      900

gcaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      960

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac     1020

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac     1080

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1140

aaggaataca agtgcgcggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1200

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1260

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tccaagcgac     1320

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1380

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1440

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1500

acgcagaaga gcctctccct gtctccgggt tccggaggag ggggttcagg tgggggaggt     1560

tctggcggcg ggggaagccc ttcacaggtg caactggtgc agagtggacc cgaggttaaa     1620

aaaccagggt cctccgttaa ggttagctgc aaagcctctg gctacacatt ttccaggagt     1680

acaatgcact gggtgaggca ggctcctgga cagggactcg agtggatcgg gtatatcaac     1740

ccatctagcg cctataccaa ttacaaccaa aagtttaagg accgagttac cattaccgct     1800

gacaaatcca ccagtacagc ttatatggag ctgtcatctc ttaggtccga ggacactgct     1860

gtttattact gcgctcgtcc tcaggttcac tatgactata atggttttcc ctactggggt     1920

cagggaaccc tggtgactgt ctcttctggc ggtggaggca gcggtggggg tgggtctgga     1980

ggcggtggca gtggcggcgg aggctctgat attcagatga ctcagtctcc tagcactctc     2040

agcgccagcg tgggggatcg tgtgacaatg acttgctccg ctagcagtag tgtgtcttac     2100

atgaattggt atcagcagaa gcccgggaaa gcacctaagc gctggatcta tgactcttcc     2160

aagctggcaa gtggtgtccc ctcacggttc tctggctcag gttctggtac tgactatact     2220

ttgactatct cctccctcca gcccgatgat ttcgctacct attattgtca gcagtggagc     2280

cgtaacccac ccactttcgg aggcggtacc aaagtggaga tcaagaggtc ataa           2334


<210>  312
<211>  757
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI130

<400>  312

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser His Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Pro Thr Thr Phe Gly Gly Gly Thr Lys Val Glu 
            100                 105                 110         


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Phe Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Gly Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr 
            180                 185                 190         


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Lys Glu Lys Leu Arg Tyr Phe Asp Trp 
225                 230                 235                 240 


Leu Ser Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val 
                245                 250                 255     


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
        275                 280                 285             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    290                 295                 300                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
305                 310                 315                 320 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                325                 330                 335     


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            340                 345                 350         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 
        355                 360                 365             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    370                 375                 380                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
385                 390                 395                 400 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                405                 410                 415     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            420                 425                 430         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        435                 440                 445             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    450                 455                 460                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
465                 470                 475                 480 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Gly Gly Gly Gly Ser 
                485                 490                 495     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Ser Gln Val Gln Leu 
            500                 505                 510         


Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val 
        515                 520                 525             


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser Thr Met His Trp 
    530                 535                 540                 


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn 
545                 550                 555                 560 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
                565                 570                 575     


Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser 
            580                 585                 590         


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
        595                 600                 605             


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
    610                 615                 620                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
625                 630                 635                 640 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
                645                 650                 655     


Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys 
            660                 665                 670         


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
        675                 680                 685             


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
    690                 695                 700                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
705                 710                 715                 720 


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
                725                 730                 735     


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
            740                 745                 750         


Glu Ile Lys Arg Ser 
        755         


<210>  313
<211>  2313
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI123

<400>  313
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt      120

tcctgcaagg catctggata catcttcacc gactactata tgcactgggt gcgtcaggcc      180

cctggacaag ggcttgagtg gatgggatgg atgagcccta acagtggtaa cacaggctat      240

gcacagaagt tccagggccg tgtcaccatg acccgcgaca cgtccacgag cacagtctac      300

atggagctga gcagcctgcg ttctgaggac acggccgtgt attactgtgc gagagatgcg      360

gcggattacg gtgactacgt tgcttttgat atctggggcc aagggacaat ggtcaccgtc      420

tcttcaggcg gcggcggcag cggcggcggc ggcagcggcg gcggaggctc cggcggcggc      480

ggcagcgaca tccagatgac ccagtctcca tcctccctgt ctgcatctgt aggagacaga      540

gtcaccatca cttgccgggc aagtcagagc attagcagct atctgaattg gtatcagcag      600

aaaccaggga aagcccctaa gctcctgatc tatgctgcat ccagtttgca aagtggggtc      660

ccatcaaggt tcagtggcag tggatctggg acagatttca ctctcaccat cagcagtctg      720

caacctgaag attttgcaac ttactactgt caacagagtt acagtacccc tctcactttc      780

ggcggaggta ccaaggtgga gatcaaatcc tcgagtgagc ccaaatcttc tgacaaaact      840

cacacatgcc caccgtgccc agcacctgaa gccgcgggtg caccgtcagt cttcctcttc      900

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      960

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag     1020

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc     1080

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggaatacaa gtgcgcggtc     1140

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1200

cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc     1260

agcctgacct gcctggtcaa aggcttctat ccaagcgaca tcgccgtgga gtgggagagc     1320

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1380

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1440

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1500

tctccgggtt ccggaggagg gggttcaggt gggggaggtt ctggcggcgg gggaagccct     1560

tcacaggtgc aactggtgca gagtggaccc gaggttaaaa aaccagggtc ctccgttaag     1620

gttagctgca aagcctctgg ctacacattt tccaggagta caatgcactg ggtgaggcag     1680

gctcctggac agggactcga gtggatcggg tatatcaacc catctagcgc ctataccaat     1740

tacaaccaaa agtttaagga ccgagttacc attaccgctg acaaatccac cagtacagct     1800

tatatggagc tgtcatctct taggtccgag gacactgctg tttattactg cgctcgtcct     1860

caggttcact atgactataa tggttttccc tactggggtc agggaaccct ggtgactgtc     1920

tcttctggcg gtggaggcag cggtgggggt gggtctggag gcggtggcag tggcggcgga     1980

ggctctgata ttcagatgac tcagtctcct agcactctca gcgccagcgt gggggatcgt     2040

gtgacaatga cttgctccgc tagcagtagt gtgtcttaca tgaattggta tcagcagaag     2100

cccgggaaag cacctaagcg ctggatctat gactcttcca agctggcaag tggtgtcccc     2160

tcacggttct ctggctcagg ttctggtact gactatactt tgactatctc ctccctccag     2220

cccgatgatt tcgctaccta ttattgtcag cagtggagcc gtaacccacc cactttcgga     2280

ggcggtacca aagtggagat caagaggtca taa                                  2313


<210>  314
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI123

<400>  314

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Ser Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Ala Asp Tyr Gly Asp Tyr Val Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
    130                 135                 140                 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
145                 150                 155                 160 


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala 
            180                 185                 190         


Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    210                 215                 220                 


Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser 
                245                 250                 255     


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
            260                 265                 270         


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Pro Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Pro Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val 
            500                 505                 510         


Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        515                 520                 525             


Thr Phe Ser Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln 
    530                 535                 540                 


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn 
545                 550                 555                 560 


Tyr Asn Gln Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser 
                565                 570                 575     


Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
            580                 585                 590         


Ala Val Tyr Tyr Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly 
        595                 600                 605             


Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser 
                645                 650                 655     


Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser 
            660                 665                 670         


Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp 
        675                 680                 685             


Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    690                 695                 700                 


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
705                 710                 715                 720 


Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro 
                725                 730                 735     


Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser 
            740                 745                 750 


<210>  315
<211>  2307
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI124

<400>  315
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcaagtca gagcattagc agctatctga attggtatca gcagaaacca      180

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      240

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      300

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcgga      360

ggtaccaagg tggagatcaa aggcggcggc ggcagcggcg gcggcggcag cggcggcgga      420

ggctccggcg gcggcggcag ccaggtgcag ctggtgcagt ctggggctga ggtgaagaag      480

cctggggcct cagtgaaggt ttcctgcaag gcatctggat acatcttcac cgactactat      540

atgcactggg tgcgtcaggc ccctggacaa gggcttgagt ggatgggatg gatgagccct      600

aacagtggta acacaggcta tgcacagaag ttccagggcc gtgtcaccat gacccgcgac      660

acgtccacga gcacagtcta catggagctg agcagcctgc gttctgagga cacggccgtg      720

tattactgtg cgagagatgc ggcggattac ggtgactacg ttgcttttga tatctggggc      780

caagggacaa tggtcaccgt ctcctcgagt gagcccaaat cttctgacaa aactcacaca      840

tgcccaccgt gcccagcacc tgaagccgcg ggtgcaccgt cagtcttcct cttcccccca      900

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      960

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1020

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1080

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggaat acaagtgcgc ggtctccaac     1140

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1200

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1260

acctgcctgg tcaaaggctt ctatccaagc gacatcgccg tggagtggga gagcaatggg     1320

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1380

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1440

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1500

ggttccggag gagggggttc aggtggggga ggttctggcg gcgggggaag cccttcacag     1560

gtgcaactgg tgcagagtgg acccgaggtt aaaaaaccag ggtcctccgt taaggttagc     1620

tgcaaagcct ctggctacac attttccagg agtacaatgc actgggtgag gcaggctcct     1680

ggacagggac tcgagtggat cgggtatatc aacccatcta gcgcctatac caattacaac     1740

caaaagttta aggaccgagt taccattacc gctgacaaat ccaccagtac agcttatatg     1800

gagctgtcat ctcttaggtc cgaggacact gctgtttatt actgcgctcg tcctcaggtt     1860

cactatgact ataatggttt tccctactgg ggtcagggaa ccctggtgac tgtctcttct     1920

ggcggtggag gcagcggtgg gggtgggtct ggaggcggtg gcagtggcgg cggaggctct     1980

gatattcaga tgactcagtc tcctagcact ctcagcgcca gcgtggggga tcgtgtgaca     2040

atgacttgct ccgctagcag tagtgtgtct tacatgaatt ggtatcagca gaagcccggg     2100

aaagcaccta agcgctggat ctatgactct tccaagctgg caagtggtgt cccctcacgg     2160

ttctctggct caggttctgg tactgactat actttgacta tctcctccct ccagcccgat     2220

gatttcgcta cctattattg tcagcagtgg agccgtaacc cacccacttt cggaggcggt     2280

accaaagtgg agatcaagag gtcataa                                         2307


<210>  316
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI124

<400>  316

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
    130                 135                 140                 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asp Tyr Tyr 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                165                 170                 175     


Trp Met Ser Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe Gln 
            180                 185                 190         


Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met 
        195                 200                 205             


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Asp Ala Ala Asp Tyr Gly Asp Tyr Val Ala Phe Asp Ile Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Met Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Pro Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys 
            500                 505                 510         


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        515                 520                 525             


Ser Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    530                 535                 540                 


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn 
545                 550                 555                 560 


Gln Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
                565                 570                 575     


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            580                 585                 590         


Tyr Tyr Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro 
        595                 600                 605             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    610                 615                 620                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
                645                 650                 655     


Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            660                 665                 670         


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        675                 680                 685             


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    690                 695                 700                 


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
705                 710                 715                 720 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                725                 730                 735     


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser 
            740                 745             


<210>  317
<211>  2304
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI139

<400>  317
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt      120

tcctgcaagg catctggagg caccttcagc agctatgcta tcagctgggt gcgtcaggcc      180

cctggacaag ggcttgagtg gatgggctgg atcacccctc acaatggtaa cataaagtat      240

gcacgggagt tccagggccg tgtcaccatg acccgcgaca cgtccacgag cacagtctac      300

atggagctga gcagcctgcg ttctgaggac acggccgtgt attactgtgc gaaagatctg      360

aactggaacg cagcctttga ctactggggc caggggaccc tggtcaccgt ctcctcaggt      420

ggaggcggtt caggcggagg tggatccggc ggtggcggct ccggtggcgg cggatctgac      480

atccagatga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc      540

acttgccggg caagtcagag cattagcagc tatctgaatt ggtatcagca gaaaccaggg      600

aaagccccta agctcctgat ctatgctgca tccagtttgc aaagtggggt cccatcaagg      660

ttcagtggca gtggatctgg gacagatttc actctcacca tcagcagtct gcaacctgaa      720

gattttgcaa cttactactg tcaacagagt tacagtaccc ctctcacttt cggcggaggt      780

accaaggtgg agatcaaatc ctcgagtgag cccaaatctt ctgacaaaac tcacacatgc      840

ccaccgtgcc cagcacctga agccgcgggt gcaccgtcag tcttcctctt ccccccaaaa      900

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      960

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat     1020

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1080

accgtcctgc accaggactg gctgaatggc aaggaataca agtgcgcggt ctccaacaaa     1140

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1200

caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc     1260

tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag     1320

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1380

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1440

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1500

tccggaggag ggggttcagg tgggggaggt tctggcggcg ggggaagccc ttcacaggtg     1560

caactggtgc agagtggacc cgaggttaaa aaaccagggt cctccgttaa ggttagctgc     1620

aaagcctctg gctacacatt ttccaggagt acaatgcact gggtgaggca ggctcctgga     1680

cagggactgg agtggatcgg gtatatcaac ccatctagcg cctataccaa ttacaaccaa     1740

aagtttaagg accgagttac cattaccgct gacaaatcca ccagtacagc ttatatggag     1800

ctgtcatctc ttaggtccga ggacactgct gtttattact gcgctcgtcc tcaggttcac     1860

tatgactata atggttttcc ctactggggt cagggaaccc tggtgactgt ctcttctggc     1920

ggtggaggca gcggtggggg tgggtctgga ggcggtggca gtggcggcgg aggctctgat     1980

attcagatga ctcagtctcc tagcactctc agcgccagcg tgggggatcg tgtgacaatg     2040

acttgctccg ctagcagtag tgtgtcttac atgaattggt atcagcagaa gcccgggaaa     2100

gcacctaagc gctggatcta tgactcttcc aagctggcaa gtggtgtccc ctcacggttc     2160

tctggctcag gttctggtac tgactatact ttgactatct cctccctcca gcccgatgat     2220

ttcgctacct attattgtca gcagtggagc cgtaacccac ccactttcgg aggcggtacc     2280

aaagtggaga tcaagaggtc atga                                            2304


<210>  318
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI139

<400>  318

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Thr Pro His Asn Gly Asn Ile Lys Tyr Ala Arg Glu Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Leu Asn Trp Asn Ala Ala Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                485                 490                 495     


Pro Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro 
            500                 505                 510         


Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser 
        515                 520                 525             


Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
    530                 535                 540                 


Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln 
545                 550                 555                 560 


Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr 
                565                 570                 575     


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
            580                 585                 590         


Tyr Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr 
        595                 600                 605             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
625                 630                 635                 640 


Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp 
                645                 650                 655     


Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
            660                 665                 670         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp 
        675                 680                 685             


Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    690                 695                 700                 


Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp 
705                 710                 715                 720 


Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe 
                725                 730                 735     


Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser 
            740                 745         


<210>  319
<211>  2313
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI137

<400>  319
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt      120

tcctgcaagg catctggata catcttcacc gactactata tgcactgggt gcgtcaggcc      180

cctggacaag ggcttgagtg gatgggatgg atgagcccta acagtggtaa cacaggctat      240

gcacagaagt tccagggccg tgtcaccatg acccgcgaca cgtccacgag cacagtctac      300

atggagctga gcagcctgcg ttctgaggac acggccgtgt attactgtgc gagagatgcg      360

gcggattacg gtgactacgt tgcttttgat atctggggcc aagggacaat ggtcaccgtc      420

tcttcaggtg gaggcggttc aggcggaggt ggatccggcg gtggcggctc cggtggcggc      480

ggatctgaca tccagatgac ccagtctcca tcctccctgt ctgcatctgt aggagacaga      540

gtcaccatca cttgccgggc aagtcagagc attagcagct atctgaattg gtatcagcag      600

aaaccaggga aagcccctaa gctcctgatc tatgctgcat ccagtttgca aagtggggtc      660

ccatcaaggt tcagtggcag tggatctggg acagatttca ctctcaccat cagcagtctg      720

caacctgaag attttgcaac ttactactgt caacagagtt acagtacccc tctcactttc      780

ggcggaggta ccaaggtgga gatcaaatcc tcgagtgagc ccaaatcttc tgacaaaact      840

cacacatgcc caccgtgccc agcacctgaa gccgcgggtg caccgtcagt cttcctcttc      900

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      960

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag     1020

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc     1080

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggaatacaa gtgcgcggtc     1140

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1200

cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc     1260

agcctgacct gcctggtcaa aggcttctat ccaagcgaca tcgccgtgga gtgggagagc     1320

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1380

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1440

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1500

tctccgggtt ccggaggagg gggttcaggt gggggaggtt ctggcggcgg gggaagccct     1560

tcacaggtgc aactggtgca gagtggaccc gaggttaaaa aaccagggtc ctccgttaag     1620

gttagctgca aagcctctgg ctacacattt tccaggagta caatgcactg ggtgaggcag     1680

gctcctggac agggactcga gtggatcggg tatatcaacc catctagcgc ctataccaat     1740

tacaaccaaa agtttaagga ccgagttacc attaccgctg acaaatccac cagtacagct     1800

tatatggagc tgtcatctct taggtccgag gacactgctg tttattactg cgctcgtcct     1860

caggttcact atgactataa tggttttccc tactggggtc agggaaccct ggtgactgtc     1920

tcttctggcg gtggaggcag cggtgggggt gggtctggag gcggtggcag tggcggcgga     1980

ggctctgata ttcagatgac tcagtctcct agcactctca gcgccagcgt gggggatcgt     2040

gtgacaatga cttgctccgc tagcagtagt gtgtcttaca tgaattggta tcagcagaag     2100

cccgggaaag cacctaagcg ctggatctat gactcttcca agctggcaag tggtgtcccc     2160

tcacggttct ctggctcagg ttctggtact gactatactt tgactatctc ctccctccag     2220

cccgatgatt tcgctaccta ttattgtcag cagtggagcc gtaacccacc cactttcgga     2280

ggcggtacca aagtggagat caagaggtca tga                                  2313


<210>  320
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI137

<400>  320

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Ser Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Ala Asp Tyr Gly Asp Tyr Val Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
    130                 135                 140                 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
145                 150                 155                 160 


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala 
            180                 185                 190         


Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    210                 215                 220                 


Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser 
                245                 250                 255     


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
            260                 265                 270         


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Pro Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Pro Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val 
            500                 505                 510         


Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        515                 520                 525             


Thr Phe Ser Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln 
    530                 535                 540                 


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn 
545                 550                 555                 560 


Tyr Asn Gln Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser 
                565                 570                 575     


Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
            580                 585                 590         


Ala Val Tyr Tyr Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly 
        595                 600                 605             


Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser 
                645                 650                 655     


Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser 
            660                 665                 670         


Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp 
        675                 680                 685             


Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    690                 695                 700                 


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
705                 710                 715                 720 


Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro 
                725                 730                 735     


Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser 
            740                 745                 750 


<210>  321
<211>  2304
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI125

<400>  321
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt      120

tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgtcaggcc      180

cctggacaag ggcttgagtg gatggggtgg atcaacccta acagtggtga cacaagctat      240

gcacagaagt tccagggccg tgtcaccatg acccgcgaca cgtccacgag cacagtctac      300

atggagctga gcagcctgcg ttctgaggac acggccgtgt attactgtgc gcaggatagt      360

agtggttccg gggcttttga tatctggggc caagggacaa tggtcaccgt ctcttcaggc      420

ggcggcggca gcggcggcgg cggcagcggc ggcggaggct ccggcggcgg cggcagcgac      480

atccagatga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc      540

acttgccggg caagtcagag cattagcagc tatctgaatt ggtatcagca gaaaccaggg      600

aaagccccta agctcctgat ctatgctgca tccagtttgc aaagtggggt cccatcaagg      660

ttcagtggca gtggatctgg gacagatttc actctcacca tcagcagtct gcaacctgaa      720

gattttgcaa cttactactg tcaacagagt tacagtaccc ctctcacttt cggcggaggt      780

accaaggtgg agatcaaatc ctcgagtgag cccaaatctt ctgacaaaac tcacacatgc      840

ccaccgtgcc cagcacctga agccgcgggt gcaccgtcag tcttcctctt ccccccaaaa      900

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      960

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat     1020

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1080

accgtcctgc accaggactg gctgaatggc aaggaataca agtgcgcggt ctccaacaaa     1140

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1200

caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc     1260

tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag     1320

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1380

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1440

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1500

tccggaggag ggggttcagg tgggggaggt tctggcggcg ggggaagccc ttcacaggtg     1560

caactggtgc agagtggacc cgaggttaaa aaaccagggt cctccgttaa ggttagctgc     1620

aaagcctctg gctacacatt ttccaggagt acaatgcact gggtgaggca ggctcctgga     1680

cagggactcg agtggatcgg gtatatcaac ccatctagcg cctataccaa ttacaaccaa     1740

aagtttaagg accgagttac cattaccgct gacaaatcca ccagtacagc ttatatggag     1800

ctgtcatctc ttaggtccga ggacactgct gtttattact gcgctcgtcc tcaggttcac     1860

tatgactata atggttttcc ctactggggt cagggaaccc tggtgactgt ctcttctggc     1920

ggtggaggca gcggtggggg tgggtctgga ggcggtggca gtggcggcgg aggctctgat     1980

attcagatga ctcagtctcc tagcactctc agcgccagcg tgggggatcg tgtgacaatg     2040

acttgctccg ctagcagtag tgtgtcttac atgaattggt atcagcagaa gcccgggaaa     2100

gcacctaagc gctggatcta tgactcttcc aagctggcaa gtggtgtccc ctcacggttc     2160

tctggctcag gttctggtac tgactatact ttgactatct cctccctcca gcccgatgat     2220

ttcgctacct attattgtca gcagtggagc cgtaacccac ccactttcgg aggcggtacc     2280

aaagtggaga tcaagaggtc ataa                                            2304


<210>  322
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI125

<400>  322

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Asp Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gln Asp Ser Ser Gly Ser Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                485                 490                 495     


Pro Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro 
            500                 505                 510         


Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser 
        515                 520                 525             


Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
    530                 535                 540                 


Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln 
545                 550                 555                 560 


Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr 
                565                 570                 575     


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
            580                 585                 590         


Tyr Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr 
        595                 600                 605             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
625                 630                 635                 640 


Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp 
                645                 650                 655     


Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
            660                 665                 670         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp 
        675                 680                 685             


Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    690                 695                 700                 


Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp 
705                 710                 715                 720 


Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe 
                725                 730                 735     


Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser 
            740                 745         


<210>  323
<211>  2316
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI126

<400>  323
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt      120

tcctgcaagg catctggata caccttcacc ggctactata tgcactgggt gcgtcaggcc      180

cctggacaag ggcttgagtg gatgggatgg atgaacccta acagtggtaa cacaggctat      240

gcacagaagt tccagggccg tgtcaccatg acccgcgaca cgtccacgag cacagtctac      300

atggagctga gcagcctgcg ttctgaggac acggccgtgt attactgtgc gaaagaggaa      360

ccgatttttg gagtggttat ggatgctttt gatatctggg gccaagggac aatggtcacc      420

gtctcctcag gcggcggcgg cagcggcggc ggcggcagcg gcggcggagg ctccggcggc      480

ggcggcagcg acatccagat gacccagtct ccatcctccc tgtctgcatc tgtaggagac      540

agagtcacca tcacttgccg ggcaagtcag agcattagca gctatctgaa ttggtatcag      600

cagaaaccag ggaaagcccc taagctcctg atctatgctg catccagttt gcaaagtggg      660

gtcccatcaa ggttcagtgg cagtggatct gggacagatt tcactctcac catcagcagt      720

ctgcaacctg aagattttgc aacttactac tgtcaacaga gttacagtac ccctctcact      780

ttcggcggag gtaccaaggt ggagatcaaa tcctcgagtg agcccaaatc ttctgacaaa      840

actcacacat gcccaccgtg cccagcacct gaagccgcgg gtgcaccgtc agtcttcctc      900

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      960

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     1020

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     1080

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggaata caagtgcgcg     1140

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1200

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     1260

gtcagcctga cctgcctggt caaaggcttc tatccaagcg acatcgccgt ggagtgggag     1320

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1380

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1440

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1500

ctgtctccgg gttccggagg agggggttca ggtgggggag gttctggcgg cgggggaagc     1560

ccttcacagg tgcaactggt gcagagtgga cccgaggtta aaaaaccagg gtcctccgtt     1620

aaggttagct gcaaagcctc tggctacaca ttttccagga gtacaatgca ctgggtgagg     1680

caggctcctg gacagggact cgagtggatc gggtatatca acccatctag cgcctatacc     1740

aattacaacc aaaagtttaa ggaccgagtt accattaccg ctgacaaatc caccagtaca     1800

gcttatatgg agctgtcatc tcttaggtcc gaggacactg ctgtttatta ctgcgctcgt     1860

cctcaggttc actatgacta taatggtttt ccctactggg gtcagggaac cctggtgact     1920

gtctcttctg gcggtggagg cagcggtggg ggtgggtctg gaggcggtgg cagtggcggc     1980

ggaggctctg atattcagat gactcagtct cctagcactc tcagcgccag cgtgggggat     2040

cgtgtgacaa tgacttgctc cgctagcagt agtgtgtctt acatgaattg gtatcagcag     2100

aagcccggga aagcacctaa gcgctggatc tatgactctt ccaagctggc aagtggtgtc     2160

ccctcacggt tctctggctc aggttctggt actgactata ctttgactat ctcctccctc     2220

cagcccgatg atttcgctac ctattattgt cagcagtgga gccgtaaccc acccactttc     2280

ggaggcggta ccaaagtgga gatcaagagg tcataa                               2316


<210>  324
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI126

<400>  324

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Glu Pro Ile Phe Gly Val Val Met Asp Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
    130                 135                 140                 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
145                 150                 155                 160 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu 
                165                 170                 175     


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys 
                245                 250                 255     


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
            260                 265                 270         


Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        275                 280                 285             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    290                 295                 300                 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
305                 310                 315                 320 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                325                 330                 335     


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            340                 345                 350         


Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala 
        355                 360                 365             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    370                 375                 380                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
385                 390                 395                 400 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                405                 410                 415     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            420                 425                 430         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        435                 440                 445             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    450                 455                 460                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
465                 470                 475                 480 


Leu Ser Pro Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                485                 490                 495     


Gly Gly Gly Ser Pro Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu 
            500                 505                 510         


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        515                 520                 525             


Tyr Thr Phe Ser Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly 
    530                 535                 540                 


Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr 
545                 550                 555                 560 


Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys 
                565                 570                 575     


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            580                 585                 590         


Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn 
        595                 600                 605             


Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
625                 630                 635                 640 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala 
                645                 650                 655     


Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val 
            660                 665                 670         


Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg 
        675                 680                 685             


Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe 
    690                 695                 700                 


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu 
705                 710                 715                 720 


Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn 
                725                 730                 735     


Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser 
            740                 745                 750     


<210>  325
<211>  2304
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI127

<400>  325
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgcgtcacc      120

atcacttgcc gggcaagtca gaccataaac aactatttga actggtatca gcagaaacca      180

gggaaagccc ctaagctcct gatctattct gcatctactt tgcaaagtgg ggtcccatca      240

cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      300

gaagattttg caacttacta ctgtcaccag agttacactt cacctctcac tttcggcgga      360

ggtaccaagg tggagatcaa aggcggcggc ggcagcggcg gcggcggcag cggcggcgga      420

ggctccggcg gcggcggcag cgaggtgcag ctggtggagt ctgggggagg cttggtacag      480

cctggggggt ccctgcgcct ctcctgtgca gcctctggat tcacctttag cagctatgcc      540

atgagctggg tccgccaggc tccagggaag gggctggagt gggtctcagt tattagtgcc      600

aatagtgctg gtctaggcca tgcggactct gtgaagggcc ggttcaccat ctcccgcgac      660

aattccaaga acacgctgta tctgcaaatg aacagcctgc gcgccgagga cacggccgta      720

tattactgtg cgagagtggg ctatagcagc tcggctgatg cttttgatat ctggggccaa      780

gggacaatgg tcaccgtctc ctcgagtgag cccaaatctt ctgacaaaac tcacacatgc      840

ccaccgtgcc cagcacctga agccgcgggt gcaccgtcag tcttcctctt ccccccaaaa      900

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      960

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat     1020

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1080

accgtcctgc accaggactg gctgaatggc aaggaataca agtgcgcggt ctccaacaaa     1140

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1200

caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc     1260

tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag     1320

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1380

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1440

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1500

tccggaggag ggggttcagg tgggggaggt tctggcggcg ggggaagccc ttcacaggtg     1560

caactggtgc agagtggacc cgaggttaaa aaaccagggt cctccgttaa ggttagctgc     1620

aaagcctctg gctacacatt ttccaggagt acaatgcact gggtgaggca ggctcctgga     1680

cagggactcg agtggatcgg gtatatcaac ccatctagcg cctataccaa ttacaaccaa     1740

aagtttaagg accgagttac cattaccgct gacaaatcca ccagtacagc ttatatggag     1800

ctgtcatctc ttaggtccga ggacactgct gtttattact gcgctcgtcc tcaggttcac     1860

tatgactata atggttttcc ctactggggt cagggaaccc tggtgactgt ctcttctggc     1920

ggtggaggca gcggtggggg tgggtctgga ggcggtggca gtggcggcgg aggctctgat     1980

attcagatga ctcagtctcc tagcactctc agcgccagcg tgggggatcg tgtgacaatg     2040

acttgctccg ctagcagtag tgtgtcttac atgaattggt atcagcagaa gcccgggaaa     2100

gcacctaagc gctggatcta tgactcttcc aagctggcaa gtggtgtccc ctcacggttc     2160

tctggctcag gttctggtac tgactatact ttgactatct cctccctcca gcccgatgat     2220

ttcgctacct attattgtca gcagtggagc cgtaacccac ccactttcgg aggcggtacc     2280

aaagtggaga tcaagaggtc ataa                                            2304


<210>  326
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI127

<400>  326

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Ser Tyr Thr Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala 
145                 150                 155                 160 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                165                 170                 175     


Val Ile Ser Ala Asn Ser Ala Gly Leu Gly His Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Val Gly Tyr Ser Ser Ser Ala Asp Ala Phe Asp Ile Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Met Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                485                 490                 495     


Pro Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro 
            500                 505                 510         


Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser 
        515                 520                 525             


Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
    530                 535                 540                 


Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln 
545                 550                 555                 560 


Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr 
                565                 570                 575     


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
            580                 585                 590         


Tyr Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr 
        595                 600                 605             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
625                 630                 635                 640 


Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp 
                645                 650                 655     


Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
            660                 665                 670         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp 
        675                 680                 685             


Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    690                 695                 700                 


Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp 
705                 710                 715                 720 


Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe 
                725                 730                 735     


Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser 
            740                 745         


<210>  327
<211>  2325
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI131

<400>  327
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt      120

tcctgcaagg catctggata cagcctcaac ttatactata tgcactgggt gcgtcaggcc      180

cctggacaag ggcttgagtg gatgggatgg atgaacccta acagtggtaa cacaggctat      240

gcacagaagt tccagggccg tgtcaccatg acccgcgaca cgtccacgag cacagtctac      300

atggagctga gcagcctgcg ttctgaggac acggccgtgt attactgtgc gagcctcgat      360

tgtagtggtg gtagctgcta ctccgaatat gatgcttttg atatctgggg ccaagggacc      420

acggtcaccg tctcctcagg cggcggcggc agcggcggcg gcggcagcgg cggcggaggc      480

tccggcggcg gcggcagcga catccagatg acccagtctc catcctccct gtctgcatct      540

gtaggagaca gagtcaccat cacttgccgg gcaagtcaga gcattagcag ctatctgaat      600

tggtatcagc agaaaccagg gaaagcccct aagctcctga tctatgctgc atccagtttg      660

caaagtgggg tcccatcaag gttcagtggc agtggatctg ggacagattt cactctcacc      720

atcagcagtc tgcaacctga agattttgca acttactact gtcaacagag ttacagtacc      780

cctctcactt tcggcggagg taccaaggtg gagatcaaat cctcgagtga gcccaaatct      840

tctgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagccgcggg tgcaccgtca      900

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      960

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     1020

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     1080

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggaatac     1140

aagtgcgcgg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1200

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1260

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atccaagcga catcgccgtg     1320

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1380

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1440

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1500

agcctctccc tgtctccggg ttccggagga gggggttcag gtgggggagg ttctggcggc     1560

gggggaagcc cttcacaggt gcaactggtg cagagtggac ccgaggttaa aaaaccaggg     1620

tcctccgtta aggttagctg caaagcctct ggctacacat tttccaggag tacaatgcac     1680

tgggtgaggc aggctcctgg acagggactc gagtggatcg ggtatatcaa cccatctagc     1740

gcctatacca attacaacca aaagtttaag gaccgagtta ccattaccgc tgacaaatcc     1800

accagtacag cttatatgga gctgtcatct cttaggtccg aggacactgc tgtttattac     1860

tgcgctcgtc ctcaggttca ctatgactat aatggttttc cctactgggg tcagggaacc     1920

ctggtgactg tctcttctgg cggtggaggc agcggtgggg gtgggtctgg aggcggtggc     1980

agtggcggcg gaggctctga tattcagatg actcagtctc ctagcactct cagcgccagc     2040

gtgggggatc gtgtgacaat gacttgctcc gctagcagta gtgtgtctta catgaattgg     2100

tatcagcaga agcccgggaa agcacctaag cgctggatct atgactcttc caagctggca     2160

agtggtgtcc cctcacggtt ctctggctca ggttctggta ctgactatac tttgactatc     2220

tcctccctcc agcccgatga tttcgctacc tattattgtc agcagtggag ccgtaaccca     2280

cccactttcg gaggcggtac caaagtggag atcaagaggt cataa                     2325


<210>  328
<211>  754
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI131

<400>  328

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Leu Asn Leu Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Asp Cys Ser Gly Gly Ser Cys Tyr Ser Glu Tyr Asp Ala 
            100                 105                 110         


Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
145                 150                 155                 160 


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
                165                 170                 175     


Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
            180                 185                 190         


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
    210                 215                 220                 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
225                 230                 235                 240 


Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Ser Ser Ser 
                245                 250                 255     


Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            260                 265                 270         


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        275                 280                 285             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    290                 295                 300                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
305                 310                 315                 320 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                325                 330                 335     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            340                 345                 350         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala 
        355                 360                 365             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    370                 375                 380                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
385                 390                 395                 400 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                405                 410                 415     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            420                 425                 430         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        435                 440                 445             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    450                 455                 460                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
465                 470                 475                 480 


Ser Leu Ser Leu Ser Pro Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                485                 490                 495     


Gly Ser Gly Gly Gly Gly Ser Pro Ser Gln Val Gln Leu Val Gln Ser 
            500                 505                 510         


Gly Pro Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys 
        515                 520                 525             


Ala Ser Gly Tyr Thr Phe Ser Arg Ser Thr Met His Trp Val Arg Gln 
    530                 535                 540                 


Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser 
545                 550                 555                 560 


Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val Thr Ile Thr 
                565                 570                 575     


Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg 
            580                 585                 590         


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln Val His Tyr 
        595                 600                 605             


Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    610                 615                 620                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
625                 630                 635                 640 


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr 
                645                 650                 655     


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser 
            660                 665                 670         


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        675                 680                 685             


Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro 
    690                 695                 700                 


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
705                 710                 715                 720 


Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp 
                725                 730                 735     


Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            740                 745                 750         


Arg Ser 
        


<210>  329
<211>  2304
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI132

<400>  329
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt      120

tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgtcaggcc      180

cctggacaag ggcttgagtg gatgggatgg atgaacccta acagtggtaa cacaggctat      240

gcacagaagt tccagggccg tgtcaccatg acccgcgaca cgtccacgag cacagtctac      300

atggagctga gcagcctgcg ttctgaggac acggccgtgt attactgtgc aacagatctc      360

gcgggggaag ccttgttcga cccctggggc cagggcaccc tggtcaccgt ctcctcaggc      420

ggcggcggca gcggcggcgg cggcagcggc ggcggaggct ccggcggcgg cggcagcgac      480

atccagatga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc      540

acttgccggg caagtcagag cattagcagc tatctgaatt ggtatcagca gaaaccaggg      600

aaagccccta agctcctgat ctatgctgca tccagtttgc aaagtggggt cccatcaagg      660

ttcagtggca gtggatctgg gacagatttc actctcacca tcagcagtct gcaacctgaa      720

gattttgcaa cttactactg tcaacagagt tacagtaccc ctctcacttt cggcggaggt      780

accaaggtgg agatcaaatc ctcgagtgag cccaaatctt ctgacaaaac tcacacatgc      840

ccaccgtgcc cagcacctga agccgcgggt gcaccgtcag tcttcctctt ccccccaaaa      900

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      960

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat     1020

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1080

accgtcctgc accaggactg gctgaatggc aaggaataca agtgcgcggt ctccaacaaa     1140

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1200

caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc     1260

tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag     1320

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1380

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1440

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1500

tccggaggag ggggttcagg tgggggaggt tctggcggcg ggggaagccc ttcacaggtg     1560

caactggtgc agagtggacc cgaggttaaa aaaccagggt cctccgttaa ggttagctgc     1620

aaagcctctg gctacacatt ttccaggagt acaatgcact gggtgaggca ggctcctgga     1680

cagggactcg agtggatcgg gtatatcaac ccatctagcg cctataccaa ttacaaccaa     1740

aagtttaagg accgagttac cattaccgct gacaaatcca ccagtacagc ttatatggag     1800

ctgtcatctc ttaggtccga ggacactgct gtttattact gcgctcgtcc tcaggttcac     1860

tatgactata atggttttcc ctactggggt cagggaaccc tggtgactgt ctcttctggc     1920

ggtggaggca gcggtggggg tgggtctgga ggcggtggca gtggcggcgg aggctctgat     1980

attcagatga ctcagtctcc tagcactctc agcgccagcg tgggggatcg tgtgacaatg     2040

acttgctccg ctagcagtag tgtgtcttac atgaattggt atcagcagaa gcccgggaaa     2100

gcacctaagc gctggatcta tgactcttcc aagctggcaa gtggtgtccc ctcacggttc     2160

tctggctcag gttctggtac tgactatact ttgactatct cctccctcca gcccgatgat     2220

ttcgctacct attattgtca gcagtggagc cgtaacccac ccactttcgg aggcggtacc     2280

aaagtggaga tcaagaggtc ataa                                            2304


<210>  330
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI132

<400>  330

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Leu Ala Gly Glu Ala Leu Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                485                 490                 495     


Pro Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro 
            500                 505                 510         


Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser 
        515                 520                 525             


Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
    530                 535                 540                 


Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln 
545                 550                 555                 560 


Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr 
                565                 570                 575     


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
            580                 585                 590         


Tyr Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr 
        595                 600                 605             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
625                 630                 635                 640 


Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp 
                645                 650                 655     


Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
            660                 665                 670         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp 
        675                 680                 685             


Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    690                 695                 700                 


Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp 
705                 710                 715                 720 


Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe 
                725                 730                 735     


Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser 
            740                 745         


<210>  331
<211>  2337
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI134

<400>  331
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt      120

tcctgcaagg catctggata caccttcact agctatgcta tgcattgggt gcgtcaggcc      180

cctggacaag ggcttgagtg gatgggactt gttgatcctg aagatggtga aacaatatat      240

gcagagaagt tccagggccg tgtcaccatg acccgcgaca cgtccacgag cacagtctac      300

atggagctga gcagcctgcg ttctgaggac acggccgtgt attactgtgc gagacgaacg      360

tattactatg atagtagtgg ttcccgttat gcttttgata tctggggcca agggaccacg      420

gtcaccgtct cttcaggcgg cggcggcagc ggcggcggcg gcagcggcgg cggaggctcc      480

ggcggcggcg gcagcgatgt tgtgatgact cagtctccac tctccctgcc cgtcacccct      540

ggagagccgg cctccatctc ctgcaggtct agtcagagcc tcctgcatag taatggagac      600

aactatttgg attggtacct gcagaagcca gggcagtctc cacagctcct gatctatttg      660

ggttctaatc gggcctccgg ggtccctgac cgtttcagtg gcagtggatc aggcacagat      720

tttacactga aaatcagccg tgtggaggct gaggatgttg gggtttatta ctgcatgcaa      780

gctacacact ggccactcac tttcggccct ggtaccaaag tggatatcaa atcctcgagt      840

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      900

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      960

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     1020

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1080

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1140

ggcaaggaat acaagtgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1200

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1260

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc     1320

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1380

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1440

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1500

tacacgcaga agagcctctc cctgtctccg ggttccggag gagggggttc aggtggggga     1560

ggttctggcg gcgggggaag cccttcacag gtgcaactgg tgcagagtgg acccgaggtt     1620

aaaaaaccag ggtcctccgt taaggttagc tgcaaagcct ctggctacac attttccagg     1680

agtacaatgc actgggtgag gcaggctcct ggacagggac tcgagtggat cgggtatatc     1740

aacccatcta gcgcctatac caattacaac caaaagttta aggaccgagt taccattacc     1800

gctgacaaat ccaccagtac agcttatatg gagctgtcat ctcttaggtc cgaggacact     1860

gctgtttatt actgcgctcg tcctcaggtt cactatgact ataatggttt tccctactgg     1920

ggtcagggaa ccctggtgac tgtctcttct ggcggtggag gcagcggtgg gggtgggtct     1980

ggaggcggtg gcagtggcgg cggaggctct gatattcaga tgactcagtc tcctagcact     2040

ctcagcgcca gcgtggggga tcgtgtgaca atgacttgct ccgctagcag tagtgtgtct     2100

tacatgaatt ggtatcagca gaagcccggg aaagcaccta agcgctggat ctatgactct     2160

tccaagctgg caagtggtgt cccctcacgg ttctctggct caggttctgg tactgactat     2220

actttgacta tctcctccct ccagcccgat gatttcgcta cctattattg tcagcagtgg     2280

agccgtaacc cacccacttt cggaggcggt accaaagtgg agatcaagag gtcataa        2337


<210>  332
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI134

<400>  332

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Val Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Thr Tyr Tyr Tyr Asp Ser Ser Gly Ser Arg Tyr Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro 
145                 150                 155                 160 


Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His 
                165                 170                 175     


Ser Asn Gly Asp Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
    210                 215                 220                 


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
225                 230                 235                 240 


Ala Thr His Trp Pro Leu Thr Phe Gly Pro Gly Thr Lys Val Asp Ile 
                245                 250                 255     


Lys Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
            260                 265                 270         


Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe 
        275                 280                 285             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    290                 295                 300                 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
305                 310                 315                 320 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                325                 330                 335     


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            340                 345                 350         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val 
        355                 360                 365             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    370                 375                 380                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
385                 390                 395                 400 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                405                 410                 415     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            420                 425                 430         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        435                 440                 445             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    450                 455                 460                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
465                 470                 475                 480 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Ser Gln Val Gln 
            500                 505                 510         


Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser Ser Val Lys 
        515                 520                 525             


Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser Thr Met His 
    530                 535                 540                 


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile 
545                 550                 555                 560 


Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg 
                565                 570                 575     


Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu 
            580                 585                 590         


Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro 
        595                 600                 605             


Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr 
    610                 615                 620                 


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
                645                 650                 655     


Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr 
            660                 665                 670         


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
        675                 680                 685             


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala 
    690                 695                 700                 


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
705                 710                 715                 720 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr 
                725                 730                 735     


Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
            740                 745                 750         


Val Glu Ile Lys Arg Ser 
        755             


<210>  333
<211>  2307
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI128

<400>  333
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt      120

tcctgcaagg catctggata tatgttcagt ggccattctg cacactgggt gcgtcaggcc      180

cctggacaag ggcttgagtg gatgggatgg atgaacccta acagtggtaa cacaggctat      240

gcacagaagt tccagggccg tgtcaccatg acccgcgaca cgtccacgag cacagtctac      300

atggagctga gcagcctgcg ttctgaggac acggccgtgt attactgtgc gagagatagc      360

agtggctggt acgatgtctt tgactactgg ggccagggga ccctggtcac cgtctcctca      420

ggtggaggcg gttcaggcgg aggtggatcc ggcggtggcg gctccggtgg cggcggatct      480

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgcgtcacc      540

atcacttgcc gggcaagtca gggcatcaga aatgatttag gttggtatca gcagaaacca      600

gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaatcagg ggtcccatca      660

cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      720

gaagattttg caacttacta ctgtcaacag agttacggtg cccccctcac tttcggcgga      780

ggtaccaagg tggagatcaa atcctcgagt gagcccaaat cttctgacaa aactcacaca      840

tgcccaccgt gcccagcacc tgaagccgcg ggtgcaccgt cagtcttcct cttcccccca      900

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      960

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1020

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1080

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggaat acaagtgcgc ggtctccaac     1140

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1200

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1260

acctgcctgg tcaaaggctt ctatccaagc gacatcgccg tggagtggga gagcaatggg     1320

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1380

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1440

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1500

ggttccggag gagggggttc aggtggggga ggttctggcg gcgggggaag cccttcacag     1560

gtgcaactgg tgcagagtgg acccgaggtt aaaaaaccag ggtcctccgt taaggttagc     1620

tgcaaagcct ctggctacac attttccagg agtacaatgc actgggtgag gcaggctcct     1680

ggacagggac tcgagtggat cgggtatatc aacccatcta gcgcctatac caattacaac     1740

caaaagttta aggaccgagt taccattacc gctgacaaat ccaccagtac agcttatatg     1800

gagctgtcat ctcttaggtc cgaggacact gctgtttatt actgcgctcg tcctcaggtt     1860

cactatgact ataatggttt tccctactgg ggtcagggaa ccctggtgac tgtctcttct     1920

ggcggtggag gcagcggtgg gggtgggtct ggaggcggtg gcagtggcgg cggaggctct     1980

gatattcaga tgactcagtc tcctagcact ctcagcgcca gcgtggggga tcgtgtgaca     2040

atgacttgct ccgctagcag tagtgtgtct tacatgaatt ggtatcagca gaagcccggg     2100

aaagcaccta agcgctggat ctatgactct tccaagctgg caagtggtgt cccctcacgg     2160

ttctctggct caggttctgg tactgactat actttgacta tctcctccct ccagcccgat     2220

gatttcgcta cctattattg tcagcagtgg agccgtaacc cacccacttt cggaggcggt     2280

accaaagtgg agatcaagag gtcataa                                         2307


<210>  334
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI128

<400>  334

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Met Phe Ser Gly His 
            20                  25                  30          


Ser Ala His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Gly Trp Tyr Asp Val Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser 
            180                 185                 190         


Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Gly Ala Pro Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Pro Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys 
            500                 505                 510         


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        515                 520                 525             


Ser Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    530                 535                 540                 


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn 
545                 550                 555                 560 


Gln Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
                565                 570                 575     


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            580                 585                 590         


Tyr Tyr Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro 
        595                 600                 605             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    610                 615                 620                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
                645                 650                 655     


Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            660                 665                 670         


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        675                 680                 685             


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    690                 695                 700                 


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
705                 710                 715                 720 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                725                 730                 735     


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser 
            740                 745             


<210>  335
<211>  2298
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI138

<400>  335
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgcctc      120

tcctgtgcag cctctggaat caccttcagt agttatggca tgcattgggt ccgccaggct      180

ccagggaagg ggctggagtg ggtctcaggt attagttgga atagtggtaa cagagtctat      240

gtggactctg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat      300

ctgcaaatga acagcctgcg cgccgaggac acggccgtat attactgtgc gagagatact      360

aatgatgctt ttgatatctg gggccaaggg accacggtca ccgtctcctc aggtggaggc      420

ggttcaggcg gaggtggatc cggcggtggc ggctccggtg gcggcggatc tgacatccag      480

atgacccagt ctccatcctc cctgtctgca tctgtaggag acagagtcac catcacttgc      540

cgggcaagtc agagcattag cagctatctg aattggtatc agcagaaacc agggaaagcc      600

cctaagctcc tgatctatgc tgcatccagt ttgcaaagtg gggtcccatc aaggttcagt      660

ggcagtggat ctgggacaga tttcactctc accatcagca gtctgcaacc tgaagatttt      720

gcaacttact actgtcaaca gagttacagt acccctctca ctttcggcgg aggtaccaag      780

gtggagatca aatcctcgag tgagcccaaa tcttctgaca aaactcacac atgcccaccg      840

tgcccagcac ctgaagccgc gggtgcaccg tcagtcttcc tcttcccccc aaaacccaag      900

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      960

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag     1020

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1080

ctgcaccagg actggctgaa tggcaaggaa tacaagtgcg cggtctccaa caaagccctc     1140

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1200

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg     1260

gtcaaaggct tctatccaag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1320

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1380

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1440

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggttccgga     1500

ggagggggtt caggtggggg aggttctggc ggcgggggaa gcccttcaca ggtgcaactg     1560

gtgcagagtg gacccgaggt taaaaaacca gggtcctccg ttaaggttag ctgcaaagcc     1620

tctggctaca cattttccag gagtacaatg cactgggtga ggcaggctcc tggacaggga     1680

ctggagtgga tcgggtatat caacccatct agcgcctata ccaattacaa ccaaaagttt     1740

aaggaccgag ttaccattac cgctgacaaa tccaccagta cagcttatat ggagctgtca     1800

tctcttaggt ccgaggacac tgctgtttat tactgcgctc gtcctcaggt tcactatgac     1860

tataatggtt ttccctactg gggtcaggga accctggtga ctgtctcttc tggcggtgga     1920

ggcagcggtg ggggtgggtc tggaggcggt ggcagtggcg gcggaggctc tgatattcag     1980

atgactcagt ctcctagcac tctcagcgcc agcgtggggg atcgtgtgac aatgacttgc     2040

tccgctagca gtagtgtgtc ttacatgaat tggtatcagc agaagcccgg gaaagcacct     2100

aagcgctgga tctatgactc ttccaagctg gcaagtggtg tcccctcacg gttctctggc     2160

tcaggttctg gtactgacta tactttgact atctcctccc tccagcccga tgatttcgct     2220

acctattatt gtcagcagtg gagccgtaac ccacccactt tcggaggcgg taccaaagtg     2280

gagatcaaga ggtcatga                                                   2298


<210>  336
<211>  745
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI138

<400>  336

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Asn Arg Val Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Thr Asn Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Gly 
465                 470                 475                 480 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Ser 
                485                 490                 495     


Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser 
            500                 505                 510         


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser 
        515                 520                 525             


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
    530                 535                 540                 


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
545                 550                 555                 560 


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
                565                 570                 575     


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
            580                 585                 590         


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
        595                 600                 605             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
625                 630                 635                 640 


Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val 
                645                 650                 655     


Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
            660                 665                 670         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser 
        675                 680                 685             


Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    690                 695                 700                 


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
705                 710                 715                 720 


Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly 
                725                 730                 735     


Gly Thr Lys Val Glu Ile Lys Arg Ser 
            740                 745 


<210>  337
<211>  777
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI130

<400>  337

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser His Ser 
        35                  40                  45              


Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Pro Thr Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Gly Leu Glu Gly Val Ser Ala Ile Ser Gly Ser 
        195                 200                 205             


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Glu Lys Leu Arg 
                245                 250                 255     


Tyr Phe Asp Trp Leu Ser Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            260                 265                 270         


Met Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
        275                 280                 285             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val 
    290                 295                 300                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
305                 310                 315                 320 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                325                 330                 335     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            340                 345                 350         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        355                 360                 365             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    370                 375                 380                 


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
385                 390                 395                 400 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                405                 410                 415     


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            420                 425                 430         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        435                 440                 445             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    450                 455                 460                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
465                 470                 475                 480 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                485                 490                 495     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Gly 
            500                 505                 510         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Ser 
        515                 520                 525             


Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser 
    530                 535                 540                 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser 
545                 550                 555                 560 


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
                565                 570                 575     


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
            580                 585                 590         


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
        595                 600                 605             


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
    610                 615                 620                 


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
625                 630                 635                 640 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                645                 650                 655     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
            660                 665                 670         


Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val 
        675                 680                 685             


Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
    690                 695                 700                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser 
705                 710                 715                 720 


Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                725                 730                 735     


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
            740                 745                 750         


Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly 
        755                 760                 765             


Gly Thr Lys Val Glu Ile Lys Arg Ser 
    770                 775         


<210>  338
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  humanized bispecific construct TRI185

<400>  338

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser His Ser 
        35                  40                  45              


Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Pro Thr Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Gly Leu Glu Gly Val Ser Ala Ile Ser Gly Ser 
        195                 200                 205             


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Glu Lys Leu Arg 
                245                 250                 255     


Tyr Phe Asp Trp Leu Ser Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            260                 265                 270         


Met Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
        275                 280                 285             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val 
    290                 295                 300                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
305                 310                 315                 320 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                325                 330                 335     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            340                 345                 350         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        355                 360                 365             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    370                 375                 380                 


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
385                 390                 395                 400 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                405                 410                 415     


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            420                 425                 430         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        435                 440                 445             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    450                 455                 460                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
465                 470                 475                 480 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                485                 490                 495     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Gly 
            500                 505                 510         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Ser 
        515                 520                 525             


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
    530                 535                 540                 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
545                 550                 555                 560 


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                565                 570                 575     


Gly Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
            580                 585                 590         


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
        595                 600                 605             


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
    610                 615                 620                 


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
625                 630                 635                 640 


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                645                 650                 655     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            660                 665                 670         


Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly 
        675                 680                 685             


Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr 
    690                 695                 700                 


Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg 
705                 710                 715                 720 


Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg 
                725                 730                 735     


Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly 
            740                 745                 750         


Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser 
        755                 760                 765             


Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Arg Ser 
    770                 775                 780                 


<210>  339
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TRI168 - dual-affinity re-targeting molecule chain 1

<400>  339

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val 
            20                  25                  30          


Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala 
        35                  40                  45              


Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr 
65                  70                  75                  80  


Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr 
                85                  90                  95      


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu 
            100                 105                 110         


Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
        115                 120                 125             


Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln 
    130                 135                 140                 


Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
145                 150                 155                 160 


Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met Lys Trp Val Arg 
                165                 170                 175     


Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Asp Ile Ile Pro Ser 
            180                 185                 190         


Asn Gly Ala Thr Phe Tyr Asn Gln Lys Phe Lys Gly Arg Val Thr Ile 
        195                 200                 205             


Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
    210                 215                 220                 


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser His Leu Leu 
225                 230                 235                 240 


Arg Ala Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Ser Gly Gly Cys Gly Gly Gly Glu Val Ala Ala Leu Glu Lys Glu 
            260                 265                 270         


Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala 
        275                 280                 285             


Ala Leu Glu Lys 
    290         


<210>  340
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TRI168 - dual-affinity re-targeting molecule chain 2

<400>  340

Asp Phe Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser 
        115                 120                 125             


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
    130                 135                 140                 


Ala Ser Gly Phe Thr Phe Ser Thr Tyr Ala Met Asn Trp Val Arg Gln 
145                 150                 155                 160 


Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Arg Ile Arg Ser Lys Tyr 
                165                 170                 175     


Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asp Ser Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
    210                 215                 220                 


Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser Gly Gly Cys Gly Gly Gly Lys Val Ala Ala 
                245                 250                 255     


Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys 
            260                 265                 270         


Glu Lys Val Ala Ala Leu Lys Glu Ser Ser Ser Leu Asn Asp Ile Phe 
        275                 280                 285             


Glu Ala Gln Lys Ile Glu Trp His Glu Asp Tyr Lys Asp Asp Asp Asp 
    290                 295                 300                 


Lys Asp Tyr Lys Asp Asp Asp Asp Lys Asp Tyr Lys Asp Asp Asp Asp 
305                 310                 315                 320 


Lys His His His His His His His His His His 
                325                 330     


<210>  341
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cris-7 variable light chain sequence

<400>  341

Gln Val Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Phe Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Thr Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr Arg 
            100                 105         


<210>  342
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cris-7 variable heavy chain sequence

<400>  342

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     


<210>  343
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HuM291 variable light chain sequence

<400>  343

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  344
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HuM291 variable heavy chain sequence

<400>  344

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Ser Gly Tyr Thr His Tyr Asn Gln Lys Leu 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ala Tyr Tyr Asp Tyr Asp Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  345
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cris7 and DRA222 VH CDR1 (Kabat)

<400>  345

Arg Ser Thr Met His 
1               5   


<210>  346
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cris7 and DRA222 VH CDR2 (Kabat)

<400>  346

Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


<210>  347
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cris7 and DRA222 VH CDR3 (Kabat)

<400>  347

Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr 
1               5                   10      


<210>  348
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cris7 and DRA222 VL CDR1 (Kabat)

<400>  348

Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
1               5                   10  


<210>  349
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cris7 and DRA222 VL CDR2 (Kabat)

<400>  349

Asp Ser Ser Lys Leu Ala Ser 
1               5           


<210>  350
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cris7 and DRA222 VL CDR3 (Kabat)

<400>  350

Gln Gln Trp Ser Arg Asn Pro Pro Thr 
1               5                   


<210>  351
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cris7 and DRA222 VH CDR1 (IMGT)

<400>  351

Gly Tyr Thr Phe Thr Arg Ser Thr 
1               5               


<210>  352
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cris7 and DRA222 VH CDR2 (IMGT)

<400>  352

Ile Asn Pro Ser Ser Ala Tyr Thr 
1               5               


<210>  353
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cris7 and DRA222 VH CDR3 (IMGT)

<400>  353

Gln Gln Trp Ser Arg Asn Pro Pro Thr 
1               5                   


<210>  354
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cris7 and DRA222 VL CDR1 (IMGT)

<400>  354

Ala Ser Ser Ser Val Ser Tyr 
1               5           


<210>  355
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cris7 and DRA222 VL CDR2 (IMGT)

<400>  355

Asp Ser Ser 
1           


<210>  356
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cris7 and DRA222 VL CDR3 (IMGT)

<400>  356

Gln Gln Trp Ser Arg Asn Pro Pro Thr 
1               5                   


<210>  357
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  I2C VH CDR1 (Kabat)

<400>  357

Lys Tyr Ala Met Asn 
1               5   


<210>  358
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  I2C VH CDR2 (Kabat)

<400>  358

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  359
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  I2C VH CDR3 (Kabat)

<400>  359

His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
1               5                   10                  


<210>  360
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  I2C VL CDR1 (Kabat)

<400>  360

Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
1               5                   10                  


<210>  361
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  I2C VL CDR2 (Kabat)

<400>  361

Gly Thr Lys Phe Leu Ala Pro 
1               5           


<210>  362
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  I2C VL CDR3 (Kabat)

<400>  362

Val Leu Trp Tyr Ser Asn Arg Trp Val 
1               5                   


<210>  363
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  I2C VH CDR1 (IMGT)

<400>  363

Gly Phe Thr Phe Asn Lys Tyr Ala 
1               5               


<210>  364
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  I2C VH CDR2 (IMGT)

<400>  364

Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  365
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  I2C VH CDR3 (IMGT)

<400>  365

Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
1               5                   10                  15      


<210>  366
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  I2C VL CDR1 (IMGT)

<400>  366

Thr Gly Ala Val Thr Ser Gly Asn Tyr 
1               5                   


<210>  367
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  I2C VL CDR2 (IMGT)

<400>  367

Gly Thr Lys 
1           


<210>  368
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  I2C VL CDR3 (IMGT)

<400>  368

Val Leu Trp Tyr Ser Asn Arg Trp Val 
1               5                   


<210>  369
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HuM291 VH CDR1 (Kabat)

<400>  369

Ser Tyr Thr Met His 
1               5   


<210>  370
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HuM291 VH CDR2 (Kabat)

<400>  370

Tyr Ile Asn Pro Arg Ser Gly Tyr Thr His Tyr Asn Gln Lys Leu Lys 
1               5                   10                  15      


Asp 
    


<210>  371
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HuM291 VH CDR3 (Kabat)

<400>  371

Ser Ala Tyr Tyr Asp Tyr Asp Gly Phe Ala Tyr 
1               5                   10      


<210>  372
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HuM291 VL CDR1 (Kabat)

<400>  372

Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
1               5                   10  


<210>  373
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HuM291 VL CDR2 (Kabat)

<400>  373

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  374
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HuM291 VL CDR3 (Kabat)

<400>  374

Gln Gln Trp Ser Ser Asn Pro Pro Thr 
1               5                   


<210>  375
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HuM291 VH CDR1 (IMGT)

<400>  375

Gly Tyr Thr Phe Ile Ser Tyr Thr 
1               5               


<210>  376
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HuM291 VH CDR2 (IMGT)

<400>  376

Ile Asn Pro Arg Ser Gly Tyr Thr 
1               5               


<210>  377
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HuM291 VH CDR3 (IMGT)

<400>  377

Ala Arg Ser Ala Tyr Tyr Asp Tyr Asp Gly Phe Ala Tyr 
1               5                   10              


<210>  378
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HuM291 VL CDR1 (IMGT)

<400>  378

Ala Ser Ser Ser Val Ser Tyr 
1               5           


<210>  379
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HuM291 VL CDR2 (IMGT)

<400>  379

Asp Thr Ser 
1           


<210>  380
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HuM291 VL CDR3 (IMGT)

<400>  380

Gln Gln Trp Ser Ser Asn Pro Pro Thr 
1               5                   


<210>  381
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TSC455 (anti-CD3) TSC394 F87Y scFv

<400>  381

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser 
            180                 185                 190         


Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Ser Ser Ser 
                245                 250     


<210>  382
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TSC456 (anti-CD3) TSC394 E86D F87Y scFv

<400>  382

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser 
            180                 185                 190         


Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Ser Ser Ser 
                245                 250     


<210>  383
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TSC455 and TSC456 variable heavy domain

<400>  383

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  384
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TSC455 variable light domain

<400>  384

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser 
            100                 105             


<210>  385
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TSC456 variable light domain

<400>  385

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser 
            100                 105             


<210>  386
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DRA222 (anti-CD3) scFv

<400>  386

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr 
145                 150                 155                 160 


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Gln Ile Thr Ser Ser Ser 
                245         


<210>  387
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DRA222 variable heavy domain

<400>  387

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  388
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DRA222 variable light domain

<400>  388

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr Ser 
            100                 105         


<210>  389
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD3 LCDR3

<400>  389

Val Leu Trp Tyr Ser Asn Arg Trp Val 
1               5                   


