                         SEQUENCE LISTING

<110>  Mayo Foundation for Medical Education and Research
 
<120>  TARGETING PAR1 AND PAR2 TO REGULATE LIPID AND CHOLESTEROL 
       ABUNDANCE

<130>  07039-1947WO1

<150>  US 62/960,881
<151>  2020-01-14

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  3727
<212>  DNA
<213>  Homo sapiens

<400>  1
aaccgcccca gacacagcgc tcgccgaggg tcgcttggac cctgatctta cccgtgggca       60

ccctgcgctc tgcctgccgc gaagaccggc tccccgaccc gcagaagtca ggagagaggg      120

tgaagcggag cagcccgagg cggggcagcc tcccggagca gcgccgcgca gagcccggga      180

caatggggcc gcggcggctg ctgctggtgg ccgcctgctt cagtctgtgc ggcccgctgt      240

tgtctgcccg cacccgggcc cgcaggccag aatcaaaagc aacaaatgcc accttagatc      300

cccggtcatt tcttctcagg aaccccaatg ataaatatga accattttgg gaggatgagg      360

agaaaaatga aagtgggtta actgaataca gattagtctc catcaataaa agcagtcctc      420

ttcaaaaaca acttcctgca ttcatctcag aagatgcctc cggatatttg accagctcct      480

ggctgacact ctttgtccca tctgtgtaca ccggagtgtt tgtagtcagc ctcccactaa      540

acatcatggc catcgttgtg ttcatcctga aaatgaaggt caagaagccg gcggtggtgt      600

acatgctgca cctggccacg gcagatgtgc tgtttgtgtc tgtgctcccc tttaagatca      660

gctattactt ttccggcagt gattggcagt ttgggtctga attgtgtcgc ttcgtcactg      720

cagcatttta ctgtaacatg tacgcctcta tcttgctcat gacagtcata agcattgacc      780

ggtttctggc tgtggtgtat cccatgcagt ccctctcctg gcgtactctg ggaagggctt      840

ccttcacttg tctggccatc tgggctttgg ccatcgcagg ggtagtgcct ctgctcctca      900

aggagcaaac catccaggtg cccgggctca acatcactac ctgtcatgat gtgctcaatg      960

aaaccctgct cgaaggctac tatgcctact acttctcagc cttctctgct gtcttctttt     1020

ttgtgccgct gatcatttcc acggtctgtt atgtgtctat cattcgatgt cttagctctt     1080

ccgcagttgc caaccgcagc aagaagtccc gggctttgtt cctgtcagct gctgttttct     1140

gcatcttcat catttgcttc ggacccacaa acgtcctcct gattgcgcat tactcattcc     1200

tttctcacac ttccaccaca gaggctgcct actttgccta cctcctctgt gtctgtgtca     1260

gcagcataag ctgctgcatc gaccccctaa tttactatta cgcttcctct gagtgccaga     1320

ggtacgtcta cagtatctta tgctgcaaag aaagttccga tcccagcagt tataacagca     1380

gtgggcagtt gatggcaagt aaaatggata cctgctctag taacctgaat aacagcatat     1440

acaaaaagct gttaacttag gaaaagggac tgctgggagg ttaaaaagaa aagtttataa     1500

aagtgaataa cctgaggatt ctattagtcc ccacccaaac tttattgatt cacctcctaa     1560

aacaacagat gtacgacttg catacctgct ttttatggga gctgtcaagc atgtattttt     1620

gtcaattacc agaaagataa caggacgaga tgacggtgtt attccaaggg aatattgcca     1680

atgctacagt aataaatgaa tgtcacttct ggatatagct aggtgacata tacatactta     1740

catgtgtgta tatgtagatg tatgcacaca catatattat ttgcagtgca gtatagaata     1800

ggcactttaa aacactcttt ccccgcaccc cagcaattat gaaaataatc tctgattccc     1860

tgatttaata tgcaaagtct aggttggtag agtttagccc tgaacatttc atggtgttca     1920

tcaacagtga gagactccat agtttgggct tgtaccactt ttgcaaataa gtgtattttg     1980

aaattgtttg acggcaaggt ttaagttatt aagaggtaag acttagtact atctgtgcgt     2040

agaagttcta gtgttttcaa ttttaaacat atccaagttt gaattcctaa aattatggaa     2100

acagatgaaa agcctctgtt ttgatatggg tagtattttt tacattttac acactgtaca     2160

cataagccaa aactgagcat aagtcctcta gtgaatgtag gctggctttc agagtaggct     2220

attcctgaga gctgcatgtg tccgcccccg atggaggact ccaggcagca gacacatgcc     2280

agggccatgt cagacacaga ttggccagaa accttcctgc tgagcctcac agcagtgaga     2340

ctggggccac tacatttgct ccatcctcct gggattggct gtgaactgat catgtttatg     2400

agaaactggc aaagcagaat gtgatatcct aggaggtaat gaccatgaaa gacttctcta     2460

cccatcttaa aaacaacgaa agaaggcatg gacttctgga tgcccatcca ctgggtgtaa     2520

acacatctag tagttgttct gaaatgtcag ttctgatatg gaagcaccca ttatgcgctg     2580

tggccactcc aataggtgct gagtgtacag agtggaataa gacagagacc tgccctcaag     2640

agcaaagtag atcatgcata gagtgtgatg tatgtgtaat aaatatgttt cacacaaaca     2700

aggcctgtca gctaaagaag tttgaacatt tgggttacta tttcttgtgg ttataactta     2760

atgaaaacaa tgcagtacag gacatatatt ttttaaaata agtctgattt aattgggcac     2820

tatttattta caaatgtttt gctcaataga ttgctcaaat caggttttct tttaagaatc     2880

aatcatgtca gtctgcttag aaataacaga agaaaataga attgacattg aaatctagga     2940

aaattattct ataatttcca tttacttaag acttaatgag actttaaaag cattttttaa     3000

cctcctaagt atcaagtata gaaaatcttc atggaattca caaagtaatt tggaaattag     3060

gttgaaacat atctcttatc ttacgaaaaa atggtagcat tttaaacaaa atagaaagtt     3120

gcaaggcaaa tgtttattta aaagagcagg ccaggcgcgg tggctcacgc ctgtaatccc     3180

agcactttgg gaggctgagg cgggtggatc acgaggtcag gagatcgaga ccatcctggc     3240

taacacggtg aaacccgtct ctactaaaaa tgcaaaaaaa attagccggg cgtggtggca     3300

ggcacctgta gtcccagcta ctcgggaggc tgaggcagga gactggcgtg aacccaggag     3360

gcggaccttg tagtgagccg agatcgcgcc actgtgctcc agcctgggca acagagcaag     3420

actccatctc aaaaaataaa aataaataaa aaataaaaaa ataaaagagc aaactatttc     3480

caaataccat agaataactt acataaaagt aatataactg tattgtaagt agaagctagc     3540

actggtttta ttaatttagt gactattcat tttatctaaa tcagtgaaga tttactgtca     3600

ttgtttatta gtctgtatat attaaaatat gatatcatta atgtacttac aaaatagtat     3660

gtcactgttt ttatgttcat tcttaaaaac ataacctgta ttaataaatg tgaacatttg     3720

cttggta                                                               3727


<210>  2
<211>  1275
<212>  DNA
<213>  Homo sapiens

<400>  2
tcggtgcgtc cagtggagct ctgagtttcg aatcggtggc ggcggattcc ccgcgcgccc       60

ggcgtcgggg cttccaggag gatgcggagc cccagcgcgg cgtggctgct gggggccgcc      120

atcctgctag cagcctctct ctcctgcagt ggcaccatcc aaggaaccaa tagatcctct      180

aaaggaagaa gccttattgg taaggttgat ggcacatccc acgtcactgg aaaaggagtt      240

acagttgaaa cagtcttttc tgtggatgag ttttctgcat ctgtcctcac tggaaaactg      300

accactgtct tccttccaat tgtctacaca attgtgtttg tggtgggttt gccaagtaac      360

ggcatggccc tgtgggtctt tcttttccga actaagaaga agcaccctgc tgtgatttac      420

atggccaatc tggccttggc tgacctcctc tctgtcatct ggttcccctt gaagattgcc      480

tatcacatac atggcaacaa ctggatttat ggggaagctc tttgtaatgt gcttattggc      540

tttttctatg gcaacatgta ctgttccatt ctcttcatga cctgcctcag tgtgcagagg      600

tattgggtca tcgtgaaccc catggggcac tccaggaaga aggcaaacat tgccattggc      660

atctccctgg caatatggct gctgattctg ctggtcacca tccctttgta tgtcgtgaag      720

cagaccatct tcattcctgc cctgaacatc acgacctgtc atgatgtttt gcctgagcag      780

ctcttggtgg gagacatgtt caattacttc ctctctctgg ccattggggt ctttctgttc      840

ccagccttcc tcacagcctc tgcctatgtg ctgatgatca gaatgctgcg atcttctgcc      900

atggatgaaa actcagagaa gaaaaggaag agggccatca aactcattgt cactgtcctg      960

gccatgtacc tgatctgctt cactcctagt aaccttctgc ttgtggtgca ttattttctg     1020

attaagagcc agggccagag ccatgtctat gccctgtaca ttgtagccct ctgcctctct     1080

acccttaaca gctgcatcga cccctttgtc tattactttg tttcacatga tttcagggat     1140

catgcaaaga acgctctcct ttgccgaagt gtccgcactg taaagcagat gcaagtatcc     1200

ctcacctcaa agaaacactc caggaaatcc agctcttact cttcaagttc aaccactgtt     1260

aagacctcct attga                                                      1275


<210>  3
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  3

Thr Phe Leu Leu Arg 
1               5   


<210>  4
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  4

Ser Leu Ile Gly Lys Val 
1               5       


<210>  5
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Leu at residue 1 is a 2-furoyl-Leu

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Orn

<400>  5

Leu Ile Gly Ala Leu Xaa 
1               5       


