                         LISTADO DE SECUENCIAS

<110>  Consejo Superior de Investigaciones Cientficas (CSIC)
       Instituto de Investigacin Sanitaria Aragn (IIS Aragn)
       Instituto Aragons de Ciencias de la Salud (IACS)
       Universidad de Zaragoza 
       Fundacin Agencia Aragonesa para la Investigacin y el Desarrollo (ARAID)
 
<120>  TIROSINASA DE CHAMPION COMO INHIBIDOR DEL VIRUS DE LA HEPATITIS 
       C

<130>  PCT1641.1506

<150>  ES P202030029
<151>  2020-01-17

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tyr45 o TyrAB (H1H2)

<400>  1

Met Ser Asp Lys Lys Ser Leu Met Pro Leu Val Gly Ile Pro Gly Glu 
1               5                   10                  15      


Ile Lys Asn Arg Leu Asn Ile Leu Asp Phe Val Lys Asn Asp Lys Phe 
            20                  25                  30          


Phe Thr Leu Tyr Val Arg Ala Leu Gln Val Leu Gln Ala Arg Asp Gln 
        35                  40                  45              


Ser Asp Tyr Ser Ser Phe Phe Gln Leu Gly Gly Ile His Gly Leu Pro 
    50                  55                  60                  


Tyr Thr Glu Trp Ala Lys Ala Gln Pro Gln Leu His Leu Tyr Lys Ala 
65                  70                  75                  80  


Asn Tyr Cys Thr His Gly Thr Val Leu Phe Pro Thr Trp His Arg Ala 
                85                  90                  95      


Tyr Glu Ser Thr Trp Glu Gln Thr Leu Trp Glu Ala Ala Gly Thr Val 
            100                 105                 110         


Ala Gln Arg Phe Thr Thr Ser Asp Gln Ala Glu Trp Ile Gln Ala Ala 
        115                 120                 125             


Lys Asp Leu Arg Gln Pro Phe Trp Asp Trp Gly Tyr Trp Pro Asn Asp 
    130                 135                 140                 


Pro Asp Phe Ile Gly Leu Pro Asp Gln Val Ile Arg Asp Lys Gln Val 
145                 150                 155                 160 


Glu Ile Thr Asp Tyr Asn Gly Thr Lys Ile Glu Val Glu Asn Pro Ile 
                165                 170                 175     


Leu His Tyr Lys Phe His Pro Ile Glu Pro Thr Phe Glu Gly Asp Phe 
            180                 185                 190         


Ala Gln Trp Gln Thr Thr Met Arg Tyr Pro Asp Val Gln Lys Gln Glu 
        195                 200                 205             


Asn Ile Glu Gly Met Ile Ala Gly Ile Lys Ala Ala Ala Pro Gly Phe 
    210                 215                 220                 


Arg Glu Trp Thr Phe Asn Met Leu Thr Lys Asn Tyr Thr Trp Glu Leu 
225                 230                 235                 240 


Phe Ser Asn His Gly Ala Val Val Gly Ala His Ala Asn Ser Leu Glu 
                245                 250                 255     


Met Val His Asn Thr Val His Phe Leu Ile Gly Arg Asp Pro Thr Leu 
            260                 265                 270         


Asp Pro Leu Val Pro Gly His Met Gly Ser Val Pro His Ala Ala Phe 
        275                 280                 285             


Asp Pro Ile Phe Trp Met His His Cys Asn Val Asp Arg Leu Leu Ala 
    290                 295                 300                 


Leu Trp Gln Thr Met Asn Tyr Asp Val Tyr Val Ser Glu Gly Met Asn 
305                 310                 315                 320 


Arg Glu Ala Thr Met Gly Leu Ile Pro Gly Gln Val Leu Thr Glu Asp 
                325                 330                 335     


Ser Pro Leu Glu Pro Phe Tyr Thr Lys Asn Gln Asp Pro Trp Gln Ser 
            340                 345                 350         


Asp Asp Leu Glu Asp Trp Glu Thr Leu Gly Phe Ser Tyr Pro Asp Phe 
        355                 360                 365             


Asp Pro Val Lys Gly Lys Ser Lys Glu Glu Lys Ser Val Tyr Ile Asn 
    370                 375                 380                 


Asp Trp Val His Lys His Tyr Gly Met Ser Asp Lys Lys Ser Leu Met 
385                 390                 395                 400 


Pro Leu Val Gly Ile Pro Gly Glu Ile Lys Asn Arg Leu Asn Ile Leu 
                405                 410                 415     


Asp Phe Val Lys Asn Asp Lys Phe Phe Thr Leu Tyr Val Arg Ala Leu 
            420                 425                 430         


Gln Val Leu Gln Ala Arg Asp Gln Ser Asp Tyr Ser Ser Phe Phe Gln 
        435                 440                 445             


Leu Gly Gly Ile His Gly Leu Pro Tyr Thr Glu Trp Ala Lys Ala Gln 
    450                 455                 460                 


Pro Gln Leu His Leu Tyr Lys Ala Asn Tyr Cys Thr His Gly Thr Val 
465                 470                 475                 480 


Leu Phe Pro Thr Trp His Arg Ala Tyr Glu Ser Thr Trp Glu Gln Thr 
                485                 490                 495     


Leu Trp Glu Ala Ala Gly Thr Val Ala Gln Arg Phe Thr Thr Ser Asp 
            500                 505                 510         


Gln Ala Glu Trp Ile Gln Ala Ala Lys Asp Leu Arg Gln Pro Phe Trp 
        515                 520                 525             


Asp Trp Gly Tyr Trp Pro Asn Asp Pro Asp Phe Ile Gly Leu Pro Asp 
    530                 535                 540                 


Gln Val Ile Arg Asp Lys Gln Val Glu Ile Thr Asp Tyr Asn Gly Thr 
545                 550                 555                 560 


Lys Ile Glu Val Glu Asn Pro Ile Leu His Tyr Lys Phe His Pro Ile 
                565                 570                 575     


Glu Pro Thr Phe Glu Gly Asp Phe Ala Gln Trp Gln Thr Thr Met Arg 
            580                 585                 590         


Tyr Pro Asp Val Gln Lys Gln Glu Asn Ile Glu Gly Met Ile Ala Gly 
        595                 600                 605             


Ile Lys Ala Ala Ala Pro Gly Phe Arg Glu Trp Thr Phe Asn Met Leu 
    610                 615                 620                 


Thr Lys Asn Tyr Thr Trp Glu Leu Phe Ser Asn His Gly Ala Val Val 
625                 630                 635                 640 


Gly Ala His Ala Asn Ser Leu Glu Met Val His Asn Thr Val His Phe 
                645                 650                 655     


Leu Ile Gly Arg Asp Pro Thr Leu Asp Pro Leu Val Pro Gly His Met 
            660                 665                 670         


Gly Ser Val Pro His Ala Ala Phe Asp Pro Ile Phe Trp Met His His 
        675                 680                 685             


Cys Asn Val Asp Arg Leu Leu Ala Leu Trp Gln Thr Met Asn Tyr Asp 
    690                 695                 700                 


Val Tyr Val Ser Glu Gly Met Asn Arg Glu Ala Thr Met Gly Leu Ile 
705                 710                 715                 720 


Pro Gly Gln Val Leu Thr Glu Asp Ser Pro Leu Glu Pro Phe Tyr Thr 
                725                 730                 735     


Lys Asn Gln Asp Pro Trp Gln Ser Asp Asp Leu Glu Asp Trp Glu Thr 
            740                 745                 750         


Leu Gly Phe Ser Tyr Pro Asp Phe Asp Pro Val Lys Gly Lys Ser Lys 
        755                 760                 765             


Glu Glu Lys Ser Val Tyr Ile Asn Asp Trp Val His Lys His Tyr Gly 
    770                 775                 780                 


<210>  2
<211>  1084
<212>  PRT
<213>  Agaricus bisporus

<400>  2

Met Ser Asp Lys Lys Ser Leu Met Pro Leu Val Gly Ile Pro Gly Glu 
1               5                   10                  15      


Ile Lys Asn Arg Leu Asn Ile Leu Asp Phe Val Lys Asn Asp Lys Phe 
            20                  25                  30          


Phe Thr Leu Tyr Val Arg Ala Leu Gln Val Leu Gln Ala Arg Asp Gln 
        35                  40                  45              


Ser Asp Tyr Ser Ser Phe Phe Gln Leu Gly Gly Ile His Gly Leu Pro 
    50                  55                  60                  


Tyr Thr Glu Trp Ala Lys Ala Gln Pro Gln Leu His Leu Tyr Lys Ala 
65                  70                  75                  80  


Asn Tyr Cys Thr His Gly Thr Val Leu Phe Pro Thr Trp His Arg Ala 
                85                  90                  95      


Tyr Glu Ser Thr Trp Glu Gln Thr Leu Trp Glu Ala Ala Gly Thr Val 
            100                 105                 110         


Ala Gln Arg Phe Thr Thr Ser Asp Gln Ala Glu Trp Ile Gln Ala Ala 
        115                 120                 125             


Lys Asp Leu Arg Gln Pro Phe Trp Asp Trp Gly Tyr Trp Pro Asn Asp 
    130                 135                 140                 


Pro Asp Phe Ile Gly Leu Pro Asp Gln Val Ile Arg Asp Lys Gln Val 
145                 150                 155                 160 


Glu Ile Thr Asp Tyr Asn Gly Thr Lys Ile Glu Val Glu Asn Pro Ile 
                165                 170                 175     


Leu His Tyr Lys Phe His Pro Ile Glu Pro Thr Phe Glu Gly Asp Phe 
            180                 185                 190         


Ala Gln Trp Gln Thr Thr Met Arg Tyr Pro Asp Val Gln Lys Gln Glu 
        195                 200                 205             


Asn Ile Glu Gly Met Ile Ala Gly Ile Lys Ala Ala Ala Pro Gly Phe 
    210                 215                 220                 


Arg Glu Trp Thr Phe Asn Met Leu Thr Lys Asn Tyr Thr Trp Glu Leu 
225                 230                 235                 240 


Phe Ser Asn His Gly Ala Val Val Gly Ala His Ala Asn Ser Leu Glu 
                245                 250                 255     


Met Val His Asn Thr Val His Phe Leu Ile Gly Arg Asp Pro Thr Leu 
            260                 265                 270         


Asp Pro Leu Val Pro Gly His Met Gly Ser Val Pro His Ala Ala Phe 
        275                 280                 285             


Asp Pro Ile Phe Trp Met His His Cys Asn Val Asp Arg Leu Leu Ala 
    290                 295                 300                 


Leu Trp Gln Thr Met Asn Tyr Asp Val Tyr Val Ser Glu Gly Met Asn 
305                 310                 315                 320 


Arg Glu Ala Thr Met Gly Leu Ile Pro Gly Gln Val Leu Thr Glu Asp 
                325                 330                 335     


Ser Pro Leu Glu Pro Phe Tyr Thr Lys Asn Gln Asp Pro Trp Gln Ser 
            340                 345                 350         


Asp Asp Leu Glu Asp Trp Glu Thr Leu Gly Phe Ser Tyr Pro Asp Phe 
        355                 360                 365             


Asp Pro Val Lys Gly Lys Ser Lys Glu Glu Lys Ser Val Tyr Ile Asn 
    370                 375                 380                 


Asp Trp Val His Lys His Tyr Gly Met Ala Gln Ala Arg Lys Ile Pro 
385                 390                 395                 400 


Leu Asp Leu Pro Gly Thr Arg Ile Leu Asn Gly Ala Asn Trp Ala Asn 
                405                 410                 415     


Asn Ser Ala Thr Glu Asn Leu Ala Thr Asn Ser Gly Thr Leu Ile Ile 
            420                 425                 430         


Phe Asp Gln Ser Thr Pro Gly Gln Asp Ala Asp Arg Trp Leu Ile His 
        435                 440                 445             


Asn Tyr Leu Asp Gly Tyr Lys Ile Phe Asn Met Gly Ser Asn Asn Trp 
    450                 455                 460                 


Ala Ser Val Ser Arg Gly Asn Thr Val Leu Gly Val Ser Glu Phe Asp 
465                 470                 475                 480 


Gly Gln Thr Cys Lys Trp Ser Ile Glu Tyr Ser Gly Asn Gly Glu Glu 
                485                 490                 495     


Phe Trp Ile Arg Val Pro Arg Glu Gly Gly Gly Gly Ala Val Trp Thr 
            500                 505                 510         


Ile Lys Pro Ala Ser Ser Gln Gly Pro Thr Thr Val Phe Leu Asp Leu 
        515                 520                 525             


Leu Lys Glu Thr Asp Pro Asn Gln Arg Ile Lys Phe Ala Val Met Ser 
    530                 535                 540                 


Asp Lys Lys Ser Leu Met Pro Leu Val Gly Ile Pro Gly Glu Ile Lys 
545                 550                 555                 560 


Asn Arg Leu Asn Ile Leu Asp Phe Val Lys Asn Asp Lys Phe Phe Thr 
                565                 570                 575     


Leu Tyr Val Arg Ala Leu Gln Val Leu Gln Ala Arg Asp Gln Ser Asp 
            580                 585                 590         


Tyr Ser Ser Phe Phe Gln Leu Gly Gly Ile His Gly Leu Pro Tyr Thr 
        595                 600                 605             


Glu Trp Ala Lys Ala Gln Pro Gln Leu His Leu Tyr Lys Ala Asn Tyr 
    610                 615                 620                 


Cys Thr His Gly Thr Val Leu Phe Pro Thr Trp His Arg Ala Tyr Glu 
625                 630                 635                 640 


Ser Thr Trp Glu Gln Thr Leu Trp Glu Ala Ala Gly Thr Val Ala Gln 
                645                 650                 655     


Arg Phe Thr Thr Ser Asp Gln Ala Glu Trp Ile Gln Ala Ala Lys Asp 
            660                 665                 670         


Leu Arg Gln Pro Phe Trp Asp Trp Gly Tyr Trp Pro Asn Asp Pro Asp 
        675                 680                 685             


Phe Ile Gly Leu Pro Asp Gln Val Ile Arg Asp Lys Gln Val Glu Ile 
    690                 695                 700                 


Thr Asp Tyr Asn Gly Thr Lys Ile Glu Val Glu Asn Pro Ile Leu His 
705                 710                 715                 720 


Tyr Lys Phe His Pro Ile Glu Pro Thr Phe Glu Gly Asp Phe Ala Gln 
                725                 730                 735     


Trp Gln Thr Thr Met Arg Tyr Pro Asp Val Gln Lys Gln Glu Asn Ile 
            740                 745                 750         


Glu Gly Met Ile Ala Gly Ile Lys Ala Ala Ala Pro Gly Phe Arg Glu 
        755                 760                 765             


Trp Thr Phe Asn Met Leu Thr Lys Asn Tyr Thr Trp Glu Leu Phe Ser 
    770                 775                 780                 


Asn His Gly Ala Val Val Gly Ala His Ala Asn Ser Leu Glu Met Val 
785                 790                 795                 800 


His Asn Thr Val His Phe Leu Ile Gly Arg Asp Pro Thr Leu Asp Pro 
                805                 810                 815     


Leu Val Pro Gly His Met Gly Ser Val Pro His Ala Ala Phe Asp Pro 
            820                 825                 830         


Ile Phe Trp Met His His Cys Asn Val Asp Arg Leu Leu Ala Leu Trp 
        835                 840                 845             


Gln Thr Met Asn Tyr Asp Val Tyr Val Ser Glu Gly Met Asn Arg Glu 
    850                 855                 860                 


Ala Thr Met Gly Leu Ile Pro Gly Gln Val Leu Thr Glu Asp Ser Pro 
865                 870                 875                 880 


Leu Glu Pro Phe Tyr Thr Lys Asn Gln Asp Pro Trp Gln Ser Asp Asp 
                885                 890                 895     


Leu Glu Asp Trp Glu Thr Leu Gly Phe Ser Tyr Pro Asp Phe Asp Pro 
            900                 905                 910         


Val Lys Gly Lys Ser Lys Glu Glu Lys Ser Val Tyr Ile Asn Asp Trp 
        915                 920                 925             


Val His Lys His Tyr Gly Met Ala Gln Ala Arg Lys Ile Pro Leu Asp 
    930                 935                 940                 


Leu Pro Gly Thr Arg Ile Leu Asn Gly Ala Asn Trp Ala Asn Asn Ser 
945                 950                 955                 960 


Ala Thr Glu Asn Leu Ala Thr Asn Ser Gly Thr Leu Ile Ile Phe Asp 
                965                 970                 975     


Gln Ser Thr Pro Gly Gln Asp Ala Asp Arg Trp Leu Ile His Asn Tyr 
            980                 985                 990         


Leu Asp Gly Tyr Lys Ile Phe Asn  Met Gly Ser Asn Asn  Trp Ala Ser 
        995                 1000                 1005             


Val Ser  Arg Gly Asn Thr Val  Leu Gly Val Ser Glu  Phe Asp Gly 
    1010                 1015                 1020             


Gln Thr  Cys Lys Trp Ser Ile  Glu Tyr Ser Gly Asn  Gly Glu Glu 
    1025                 1030                 1035             


Phe Trp  Ile Arg Val Pro Arg  Glu Gly Gly Gly Gly  Ala Val Trp 
    1040                 1045                 1050             


Thr Ile  Lys Pro Ala Ser Ser  Gln Gly Pro Thr Thr  Val Phe Leu 
    1055                 1060                 1065             


Asp Leu  Leu Lys Glu Thr Asp  Pro Asn Gln Arg Ile  Lys Phe Ala 
    1070                 1075                 1080             


Val 
    


