                         б

<110>  麣ҩɷ޹˾
 
<120>  ĻＰӦ

<130>  FPCH20160327P

<160>  49    

<170>  PatentIn version 3.3

<210>  1
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  1

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  2
<211>  31
<212>  PRT
<213>  (Homo sapiens)

<400>  2

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  3
<211>  31
<212>  PRT
<213>  ˹


<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  (Glu-)

<400>  3

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  4
<211>  31
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  ([2-(2--)-]-)2-Glu-ʮ)

<400>  4

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  5
<211>  42
<212>  PRT
<213>  (Homo sapiens)

<400>  5

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  6
<211>  29
<212>  PRT
<213>  (Homo sapiens)

<400>  6

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  7
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  (Glu-CO(CH2)14CH3)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  7

His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Gln Asp Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  8
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  (Glu-CO(CH2)14CH3)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  8

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Tyr Xaa Glu Glu 
1               5                   10                  15      


Gln Ala Ala Gln Asp Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  9
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  鰱(N-Ȱ)

<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  (Glu-CO(CH2)14CH3)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  9

Xaa Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  10
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  ACETYLATION
<222>  (1)..(1)
<223>  鰱

<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  (Glu-CO(CH2)14CH3)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  10

Xaa Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  11
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  (Glu-CO(CH2)14CH3)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  11

His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  12
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  (Glu-CO(CH2)14CH3)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  12

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Xaa Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  13
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  װ(3-ǰ-Glu-NH(CH2)15CH3)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  13

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Tyr Xaa Glu Glu 
1               5                   10                  15      


Gln Ala Ala Gln Asp Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  14
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  װ(3-ǰ-AEEAc-AEEAc-NH(CH2)15CH3)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  14

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Tyr Xaa Glu Glu 
1               5                   10                  15      


Gln Ala Ala Gln Asp Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  15
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  (Glu-CO(CH2)14CH3)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  15

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Arg Tyr Xaa Glu Glu 
1               5                   10                  15      


Gln Ala Ala Gln Asp Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  16
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  (Glu-CO(CH2)14CH3)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  16

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Xaa Glu Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Ile Glu Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  17
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  (Glu-CO(CH2)14CH3)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  17

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Xaa Glu Glu 
1               5                   10                  15      


Gln Ala Ala Gln Asp Phe Ile Glu Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  18
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  (Glu-CO(CH2)14CH3)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  18

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Xaa Glu Glu 
1               5                   10                  15      


Gln Ala Ala Gln Asp Phe Ile Glu Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  19
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  (Glu-CO(CH2)14CH3)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  19

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Ile Tyr Xaa Glu Glu 
1               5                   10                  15      


Arg Ala Gln Gln Asp Phe Ile Glu Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  20
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  (Glu-CO(CH2)14CH3)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  20

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Ile Gln Xaa Glu Glu 
1               5                   10                  15      


Ile Ala Ala Gln Asp Phe Ile Glu Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  21
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  (Glu-CO(CH2)14CH3)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  21

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Xaa Glu Glu 
1               5                   10                  15      


Ile Ala Gln Gln Asp Phe Ile Glu Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  22
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  (Glu-CO(CH2)14CH3)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  22

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Xaa Tyr Leu Glu Glu 
1               5                   10                  15      


Arg Ala Gln Gln Asp Phe Ile Glu Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  23
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  (Glu-CO(CH2)14CH3)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  23

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Ile Xaa Leu Glu Glu 
1               5                   10                  15      


Arg Ala Gln Gln Asp Phe Ile Glu Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  24
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  (Glu-CO(CH2)14CH3)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  24

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Ile Tyr Leu Glu Xaa 
1               5                   10                  15      


Arg Ala Gln Gln Asp Phe Ile Glu Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  25
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  (Glu-CO(CH2)14CH3)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  25

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Ile Tyr Leu Glu Glu 
1               5                   10                  15      


Xaa Ala Gln Gln Asp Phe Ile Glu Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  26
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  (AEEAc-AEEAc-Glu-CO(CH2)16CH3)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  26

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Ile Tyr Xaa Glu Glu 
1               5                   10                  15      


Arg Ala Gln Gln Asp Phe Ile Glu Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  27
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  (AEEAc-AEEAc-Glu-CO(CH2)16COOH)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  27

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Xaa Glu Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Ile Glu Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  28
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  (Glu-Glu-AEEAc-AEEAc-CO(CH2)16COOH)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  28

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Ile Tyr Xaa Glu Glu 
1               5                   10                  15      


Arg Ala Gln Gln Asp Phe Ile Glu Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  29
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  (AEEAc-AEEAc-Glu-CO(CH2)16COOH)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  29

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Ile Gln Xaa Glu Glu 
1               5                   10                  15      


Ile Ala Ala Gln Asp Phe Val Glu Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  30
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  (AEEAc-AEEAc-Glu-CO(CH2)16COOH)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  30

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Ile Tyr Xaa Glu Glu 
1               5                   10                  15      


Arg Ala Gln Gln Asp Phe Ile Glu Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  31
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  (AEEAc-AEEAc-Glu-CO(CH2)16COOH)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  31

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Gln Xaa Glu Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Ile Glu Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  32
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  (Glu-CO(CH2)16COOH)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  32

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Ile Tyr Xaa Glu Glu 
1               5                   10                  15      


Arg Ala Gln Gln Asp Phe Ile Glu Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  33
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  (GSEGSEE-CO(CH2)16COOH)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  33

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Ile Tyr Xaa Glu Glu 
1               5                   10                  15      


Arg Ala Gln Gln Asp Phe Ile Glu Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  34
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  (Glu-Glu-AEEAc-AEEAc-Glu-CO

(CH2)16COOH)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  34

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Ile Tyr Xaa Glu Glu 
1               5                   10                  15      


Arg Ala Gln Gln Asp Phe Ile Glu Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  35
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  (Glu-GABA-AEEAc-Glu-CO(CH2)16 COOH)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  35

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Ile Tyr Xaa Glu Glu 
1               5                   10                  15      


Arg Ala Gln Gln Asp Phe Ile Glu Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  36
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  (Glu-CO(CH2)14CH3)

<400>  36

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Ile Tyr Xaa Glu Glu 
1               5                   10                  15      


Arg Ala Gln Gln Asp Phe Ile Glu Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  37
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  (Glu-CO(CH2)14CH3)

<400>  37

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Ile Gln Xaa Glu Glu 
1               5                   10                  15      


Ile Ala Ala Gln Asp Phe Ile Glu Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  38
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MUTAGEN
<222>  (14)..(14)
<223>  (AEEAc-AEEAc-Glu-CO(CH2)16COOH)

<400>  38

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Xaa Glu Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Ile Glu Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  39
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  (AEEAc-AEEAc-Glu-CO(CH2)18COOH)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  39

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Ile Gln Xaa Glu Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Ile Glu Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  40
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  (AEEAc-AEEAc-Glu-CO(CH2)18COOH)

<220>
<221>  AMIDATION
<222>  (39)..(39)
<223>  ˿

<400>  40

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Ile Tyr Xaa Glu Glu 
1               5                   10                  15      


Arg Ala Gln Gln Asp Phe Ile Glu Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  41
<211>  168
<212>  PRT
<213>  ˹

<400>  41

Met His Thr Pro Glu His Ile Thr Ala Val Val Gln Arg Phe Val Ala 
1               5                   10                  15      


Ala Leu Asn Ala Gly Asp Leu Asp Gly Ile Val Ala Leu Phe Ala Asp 
            20                  25                  30          


Asp Ala Thr Val Glu Asp Pro Val Gly Ser Glu Pro Arg Ser Gly Thr 
        35                  40                  45              


Ala Ala Ile Arg Glu Phe Tyr Ala Asn Ser Leu Lys Leu Pro Leu Ala 
    50                  55                  60                  


Val Glu Leu Thr Gln Glu Val Arg Ala Val Ala Asn Glu Ala Ala Phe 
65                  70                  75                  80  


Ala Phe Thr Val Ser Phe Glu Tyr Gln Gly Arg Lys Thr Val Val Ala 
                85                  90                  95      


Pro Ile Asp His Phe Arg Phe Asn Gly Ala Gly Lys Val Val Ser Ile 
            100                 105                 110         


Arg Ala Leu Phe Gly Glu Lys Asn Ile His Ala Cys Gln Met Leu Asp 
        115                 120                 125             


Asp Asp Asp Lys Thr Phe Thr Ser Asp Leu Ser Ile Tyr Lys Glu Glu 
    130                 135                 140                 


Arg Ala Gln Gln Asp Phe Ile Glu Trp Leu Leu Asp Gly Gly Pro Ser 
145                 150                 155                 160 


Ser Gly Ala Pro Pro Pro Ser Gly 
                165             


<210>  42
<211>  36
<212>  PRT
<213>  ˹

<400>  42

Thr Phe Thr Ser Asp Leu Ser Ile Tyr Lys Glu Glu Arg Ala Gln Gln 
1               5                   10                  15      


Asp Phe Ile Glu Trp Leu Leu Asp Gly Gly Pro Ser Ser Gly Ala Pro 
            20                  25                  30          


Pro Pro Ser Gly 
        35      


<210>  43
<211>  144
<212>  DNA
<213>  ˹

<400>  43
cagatgctgg atgacgatga caaaaccttc acctctgacc tgtctatcta caaagaagaa     60

cgtgctcagc aggacttcat cgaatggctg ctggacggtg gtccgtcttc tggtgctccg    120

ccgccgtctg gttaatgact cgag                                           144


<210>  44
<211>  36
<212>  PRT
<213>  ˹


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  (Glu-CO(CH2)14CH3)

<400>  44

Thr Phe Thr Ser Asp Leu Ser Ile Tyr Xaa Glu Glu Arg Ala Gln Gln 
1               5                   10                  15      


Asp Phe Ile Glu Trp Leu Leu Asp Gly Gly Pro Ser Ser Gly Ala Pro 
            20                  25                  30          


Pro Pro Ser Gly 
        35      


<210>  45
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa=HisHis(N-Ac)His(N-pGlu)

<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa=HisGln

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa=TyrLeuLysCys

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Xaa=IleArgLysCys

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  Xaa=TyrGlnLysCys

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa=LeuLysCys

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa=AspLysCysGlu

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa=GluLysCys

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Xaa=ArgIleGlnGluLysCys

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Xaa=AlaArg

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Xaa=AlaValGln

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa=GlnArg

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa=AspLeu

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Xaa=ValIle

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa=GluGln

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa=LeuLys

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa=AlaAsp

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Xaa=˿˿

<400>  45

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Xaa Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  46
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa=HisHis(N-Ac)His(N-pGlu)

<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa=HisGln

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa=LeuLysCys

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  Xaa=TyrGln

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa=LeuLysCys

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa=AspGlu

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Xaa=ArgGlnGlu

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Xaa=AlaVal

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa=GlnArg

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa=AspLeu

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Xaa=ValIle

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa=GluGln

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa=LeuLys

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa=AlaAsp

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Xaa=˿˿

<400>  46

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Xaa Ser Lys Xaa Xaa Xaa Glu 
1               5                   10                  15      


Xaa Ala Xaa Xaa Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  47
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa=

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Xaa=˿˿

<400>  47

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Tyr Xaa Glu Glu 
1               5                   10                  15      


Gln Ala Ala Gln Asp Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  48
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa=HisGln

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa=TyrLeu

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Xaa=IleArg

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  Xaa=TyrGln

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa=Leu

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa=Glu

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Xaa=ArgIleGln

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Xaa=AlaArg

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Xaa=AlaGln

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Xaa=ValIle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa=AlaAsp

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Xaa=˿˿

<400>  48

His Xaa Xaa Gly Thr Phe Thr Ser Asp Xaa Ser Xaa Xaa Xaa Glu Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Gln Asp Phe Xaa Glu Trp Leu Leu Xaa Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


<210>  49
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa=HisGln

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa=TyrLeu

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Xaa=IleArgLysCys

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  Xaa=TyrGlnLysCys

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa=LeuLysCys

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa=GluLysCys

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Xaa=ArgIleGlnLysCys

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Xaa=AlaArg

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Xaa=AlaGln

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Xaa=ValIle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa=AlaAsp

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Xaa=˿˿

<400>  49

His Xaa Xaa Gly Thr Phe Thr Ser Asp Xaa Ser Xaa Xaa Xaa Glu Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Gln Asp Phe Xaa Glu Trp Leu Leu Xaa Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


