                         SEQUENCE LISTING

<110>  Theraneutrics, LLC
       Theraneutrics LLC
 
<120>  Therapeutic Engineered Microbial Cell Systems and Methods for 
       Treating Hyperuricemia and Gout

<130>  HL20070

<140>  PCT/US 21/070014
<141>  2021-01-08

<150>  62959991
<151>  2020-01-12

<150>  US 62/959,991
<151>  2020-01-12

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  313
<212>  PRT
<213>  Candida utilis

<400>  1

Met Ser Thr Thr Leu Ser Ser Ser Thr Tyr Gly Lys Asp Asn Val Lys 
1               5                   10                  15      


Phe Leu Lys Val Lys Lys Asp Pro Gln Asn Pro Lys Lys Gln Glu Val 
            20                  25                  30          


Met Glu Ala Thr Val Thr Cys Leu Leu Glu Gly Gly Phe Asp Thr Ser 
        35                  40                  45              


Tyr Thr Glu Ala Asp Asn Ser Ser Ile Val Pro Thr Asp Thr Val Lys 
    50                  55                  60                  


Asn Thr Ile Leu Val Leu Ala Lys Thr Thr Glu Ile Trp Pro Ile Glu 
65                  70                  75                  80  


Arg Phe Ala Ala Lys Leu Ala Thr His Phe Val Glu Lys Tyr Ser His 
                85                  90                  95      


Val Ser Gly Val Ser Val Lys Ile Val Gln Asp Arg Trp Val Lys Tyr 
            100                 105                 110         


Ala Val Asp Gly Lys Pro His Asp His Ser Phe Ile His Glu Gly Gly 
        115                 120                 125             


Glu Lys Arg Ile Thr Asp Leu Tyr Tyr Lys Arg Ser Gly Asp Tyr Lys 
    130                 135                 140                 


Leu Ser Ser Ala Ile Lys Asp Leu Thr Val Leu Lys Ser Thr Gly Ser 
145                 150                 155                 160 


Met Phe Tyr Gly Tyr Asn Lys Cys Asp Phe Thr Thr Leu Gln Pro Thr 
                165                 170                 175     


Thr Asp Arg Ile Leu Ser Thr Asp Val Asp Ala Thr Trp Val Trp Asp 
            180                 185                 190         


Asn Lys Lys Ile Gly Thr Val Tyr Asp Ile Ala Lys Ala Ala Asp Lys 
        195                 200                 205             


Gly Ile Phe Asp Asn Val Tyr Asn Gln Ala Arg Glu Ile Thr Leu Thr 
    210                 215                 220                 


Thr Phe Ala Leu Glu Asn Ser Pro Ser Val Gln Ala Thr Met Phe Asn 
225                 230                 235                 240 


Met Ala Thr Gln Ile Leu Glu Lys Ala Cys Ser Val Tyr Ser Val Ser 
                245                 250                 255     


Tyr Ala Leu Pro Asn Lys His Tyr Phe Leu Ile Asp Leu Lys Trp Lys 
            260                 265                 270         


His Tyr Phe Leu Ile Asp Leu Lys Trp Lys Gly Leu Glu Asn Asp Asn 
        275                 280                 285             


Glu Leu Phe Tyr Pro Ser Pro His Pro Asn Gly Leu Ile Lys Cys Thr 
    290                 295                 300                 


Val Val Arg Lys Glu Lys Thr Lys Leu 
305                 310             


<210>  2
<211>  302
<212>  PRT
<213>  Unknown

<220>
<223>  Aspergillus flavus

<400>  2

Met Ser Ala Val Lys Ala Ala Arg Tyr Gly Lys Asp Asn Val Arg Val 
1               5                   10                  15      


Tyr Lys Val His Lys Asp Glu Lys Thr Gly Val Gln Thr Val Tyr Glu 
            20                  25                  30          


Met Thr Val Cys Val Leu Leu Glu Gly Glu Ile Glu Thr Ser Tyr Thr 
        35                  40                  45              


Lys Ala Asp Asn Ser Val Ile Val Ala Thr Asp Ser Ile Lys Asn Thr 
    50                  55                  60                  


Ile Tyr Ile Thr Ala Lys Gln Asn Pro Val Thr Pro Pro Glu Leu Phe 
65                  70                  75                  80  


Gly Ser Ile Leu Gly Thr His Phe Ile Glu Lys Tyr Asn His Ile His 
                85                  90                  95      


Ala Ala His Val Asn Ile Val Cys His Arg Trp Thr Arg Met Asp Ile 
            100                 105                 110         


Asp Gly Lys Pro His Pro His Ser Phe Ile Arg Asp Ser Glu Glu Lys 
        115                 120                 125             


Arg Asn Val Gln Val Asp Val Val Glu Gly Lys Gly Ile Asp Ile Lys 
    130                 135                 140                 


Ser Ser Leu Ser Gly Leu Thr Val Leu Lys Ser Thr Asn Ser Gln Phe 
145                 150                 155                 160 


Trp Gly Phe Leu Arg Asp Glu Tyr Thr Thr Leu Lys Glu Thr Trp Asp 
                165                 170                 175     


Arg Ile Leu Ser Thr Asp Val Asp Ala Thr Trp Gln Trp Lys Asn Phe 
            180                 185                 190         


Ser Gly Leu Gln Glu Val Arg Ser His Val Pro Lys Phe Asp Ala Thr 
        195                 200                 205             


Trp Ala Thr Ala Arg Glu Val Thr Leu Lys Thr Phe Ala Glu Asp Asn 
    210                 215                 220                 


Ser Ala Ser Val Gln Ala Thr Met Tyr Lys Met Ala Glu Gln Ile Leu 
225                 230                 235                 240 


Ala Arg Gln Gln Leu Ile Glu Thr Val Glu Tyr Ser Leu Pro Asn Lys 
                245                 250                 255     


His Tyr Phe Glu Ile Asp Leu Ser Trp His Lys Gly Leu Gln Asn Thr 
            260                 265                 270         


Gly Lys Asn Ala Glu Val Phe Ala Pro Gln Ser Asp Pro Asn Gly Leu 
        275                 280                 285             


Ile Lys Cys Thr Val Gly Arg Ser Ser Leu Lys Ser Lys Leu 
    290                 295                 300         


<210>  3
<211>  302
<212>  PRT
<213>  Arthrobacter globiformis

<400>  3

Met Thr Ala Thr Ala Glu Thr Ser Thr Gly Thr Lys Val Val Leu Gly 
1               5                   10                  15      


Gln Asn Gln Tyr Gly Lys Ala Glu Val Arg Leu Val Lys Val Thr Arg 
            20                  25                  30          


Asn Thr Ala Arg His Glu Ile Gln Asp Leu Asn Val Thr Ser Gln Leu 
        35                  40                  45              


Arg Gly Asp Phe Glu Ala Ala His Thr Ala Gly Asp Asn Ala His Val 
    50                  55                  60                  


Val Ala Thr Asp Thr Gln Lys Asn Thr Val Tyr Ala Phe Ala Arg Asp 
65                  70                  75                  80  


Gly Phe Ala Thr Thr Glu Glu Phe Leu Leu Arg Leu Gly Lys His Phe 
                85                  90                  95      


Thr Glu Gly Phe Asp Trp Val Thr Gly Gly Arg Trp Ala Ala Gln Gln 
            100                 105                 110         


Phe Phe Trp Asp Arg Ile Asn Asp His Asp His Ala Phe Ser Arg Asn 
        115                 120                 125             


Lys Ser Glu Val Arg Thr Ala Val Leu Glu Ile Ser Gly Ser Glu Gln 
    130                 135                 140                 


Ala Ile Val Ala Gly Ile Glu Gly Leu Thr Val Leu Lys Ser Thr Gly 
145                 150                 155                 160 


Ser Glu Phe His Gly Phe Pro Arg Asp Lys Tyr Thr Thr Leu Gln Glu 
                165                 170                 175     


Thr Thr Asp Arg Ile Leu Ala Thr Asp Val Ser Ala Arg Trp Arg Tyr 
            180                 185                 190         


Asn Thr Val Glu Val Asp Phe Asp Ala Val Tyr Ala Ser Val Arg Gly 
        195                 200                 205             


Leu Leu Leu Lys Ala Phe Ala Glu Thr His Ser Leu Ala Leu Gln Gln 
    210                 215                 220                 


Thr Met Tyr Glu Met Gly Arg Ala Val Ile Glu Thr His Pro Glu Ile 
225                 230                 235                 240 


Asp Glu Ile Lys Met Ser Leu Pro Asn Lys His His Phe Leu Val Asp 
                245                 250                 255     


Leu Gln Pro Phe Gly Gln Asp Asn Pro Asn Glu Val Phe Tyr Ala Ala 
            260                 265                 270         


Asp Arg Pro Tyr Gly Leu Ile Glu Ala Thr Ile Gln Arg Glu Gly Ser 
        275                 280                 285             


Arg Ala Asp His Pro Ile Trp Ser Asn Ile Ala Gly Phe Cys 
    290                 295                 300         


<210>  4
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct / Chimeric porcine / baboon

<400>  4

Met Ala His Tyr Arg Asn Asp Tyr Lys Lys Asn Asp Glu Val Glu Phe 
1               5                   10                  15      


Val Arg Thr Gly Tyr Gly Lys Asp Met Ile Lys Val Leu His Ile Gln 
            20                  25                  30          


Arg Asp Gly Lys Tyr His Ser Ile Lys Glu Val Ala Thr Ser Val Gln 
        35                  40                  45              


Leu Thr Leu Ser Ser Lys Lys Asp Tyr Leu His Gly Asp Asn Ser Asp 
    50                  55                  60                  


Val Ile Pro Thr Asp Thr Ile Lys Asn Thr Val Asn Val Leu Ala Lys 
65                  70                  75                  80  


Phe Lys Gly Ile Lys Ser Ile Glu Thr Phe Ala Val Thr Ile Cys Glu 
                85                  90                  95      


His Phe Leu Ser Ser Phe Lys His Val Ile Arg Ala Gln Val Tyr Val 
            100                 105                 110         


Glu Glu Val Pro Trp Lys Arg Phe Glu Lys Asn Gly Val Lys His Val 
        115                 120                 125             


His Ala Phe Ile Tyr Thr Pro Thr Gly Thr His Phe Cys Glu Val Glu 
    130                 135                 140                 


Gln Ile Arg Asn Gly Pro Pro Val Ile His Ser Gly Ile Lys Asp Leu 
145                 150                 155                 160 


Lys Val Leu Lys Thr Thr Gln Ser Gly Phe Glu Gly Phe Ile Lys Asp 
                165                 170                 175     


Gln Phe Thr Thr Leu Pro Glu Val Lys Asp Arg Cys Phe Ala Thr Gln 
            180                 185                 190         


Val Tyr Cys Lys Trp Arg Tyr His Gln Gly Arg Asp Val Asp Phe Glu 
        195                 200                 205             


Ala Thr Trp Asp Thr Val Arg Ser Ile Val Leu Gln Lys Phe Ala Gly 
    210                 215                 220                 


Pro Tyr Asp Lys Gly Glu Tyr Ser Pro Ser Val Gln Lys Thr Leu Tyr 
225                 230                 235                 240 


Asp Ile Gln Val Leu Ser Leu Ser Arg Val Pro Glu Ile Glu Asp Met 
                245                 250                 255     


Glu Ile Ser Leu Pro Asn Ile His Tyr Phe Asn Ile Asp Met Ser Lys 
            260                 265                 270         


Met Gly Leu Ile Asn Lys Glu Glu Val Leu Leu Pro Leu Asp Asn Pro 
        275                 280                 285             


Tyr Gly Lys Ile Thr Gly Thr Val Lys Arg Lys Leu Ser Ser Arg Leu 
    290                 295                 300                 


<210>  5
<211>  296
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  5

Met Ser Glu Thr Thr Tyr Val Lys Gln Cys Ala Tyr Gly Lys Thr Leu 
1               5                   10                  15      


Val Arg Phe Met Lys Lys Asp Ile Cys Pro Lys Thr Lys Thr His Thr 
            20                  25                  30          


Val Tyr Glu Met Asp Val Gln Ser Leu Leu Thr Gly Glu Leu Glu Glu 
        35                  40                  45              


Ser Tyr Thr Lys Ala Asp Asn Ser Ile Val Val Pro Thr Asp Thr Gln 
    50                  55                  60                  


Lys Asn Thr Ile Tyr Val Phe Ala Lys Asn Asn Asp Val Ser Val Pro 
65                  70                  75                  80  


Glu Val Phe Ala Ala Lys Leu Ala Lys His Phe Val Asp Lys Tyr Lys 
                85                  90                  95      


His Ile His Gly Ala Ala Leu Asp Ile Thr Ile Thr Pro Trp Thr Arg 
            100                 105                 110         


Met Glu Val Gln Gly Lys Pro His Ser His Ser Phe Ile Arg Asn Pro 
        115                 120                 125             


Gly Glu Thr Arg Lys Thr His Val Val Phe Ser Glu Gly Lys Gly Phe 
    130                 135                 140                 


Asp Val Val Ser Ser Leu Lys Asp Val Leu Val Leu Lys Ser Thr Gly 
145                 150                 155                 160 


Ser Gly Phe Thr Asn Phe His Lys Cys Glu Phe Thr Thr Leu Pro Glu 
                165                 170                 175     


Val Thr Asp Arg Ile Phe Ser Thr Ser Ile Asp Cys Asn Tyr Thr Phe 
            180                 185                 190         


Lys His Phe Asp Thr Phe Glu Glu Leu Ala Gly Phe Asp Phe Asn Ser 
        195                 200                 205             


Ile Tyr Glu Lys Val Lys Glu Ile Thr Leu Glu Thr Phe Ala Leu Asp 
    210                 215                 220                 


Asp Ser Glu Ser Val Gln Ala Thr Met Tyr Lys Met Ala Asp Thr Ile 
225                 230                 235                 240 


Ile Asn Thr Tyr Pro Ala Ile Asn Glu Val Tyr Tyr Ala Leu Pro Asn 
                245                 250                 255     


Lys His Tyr Phe Glu Ile Asn Leu Ala Pro Phe Asn Ile Asp Asn Leu 
            260                 265                 270         


Gly Ser Asn Cys Ser Leu Tyr Gln Pro Gln Ala Tyr Pro Ser Gly Tyr 
        275                 280                 285             


Ile Thr Cys Thr Val Ala Arg Lys 
    290                 295     


<210>  6
<211>  494
<212>  PRT
<213>  Bacillus subtilis

<400>  6

Met Phe Thr Met Asp Asp Leu Asn Gln Met Asp Thr Gln Thr Leu Thr 
1               5                   10                  15      


Asp Thr Leu Gly Ser Ile Phe Glu His Ser Ser Trp Ile Ala Glu Arg 
            20                  25                  30          


Ser Ala Ala Leu Arg Pro Phe Ser Ser Leu Ser Asp Leu His Arg Lys 
        35                  40                  45              


Met Thr Gly Ile Val Lys Ala Ala Asp Arg Glu Thr Gln Leu Asp Leu 
    50                  55                  60                  


Ile Lys Lys His Pro Arg Leu Gly Thr Lys Lys Thr Met Ser Gly Asp 
65                  70                  75                  80  


Ser Val Arg Glu Gln Gln Asn Ala Gly Leu Ser Lys Leu Glu Gln Gln 
                85                  90                  95      


Glu Tyr Glu Glu Phe Leu Met Leu Asn Glu His Tyr Tyr Asp Arg Phe 
            100                 105                 110         


Gly Phe Pro Phe Ile Leu Ala Val Lys Gly Lys Thr Lys Gln Asp Ile 
        115                 120                 125             


His Gln Ala Leu Leu Ala Arg Leu Glu Ser Glu Arg Glu Thr Glu Phe 
    130                 135                 140                 


Gln Gln Ala Leu Ile Glu Ile Tyr Arg Ile Ala Arg Phe Arg Leu Ala 
145                 150                 155                 160 


Asp Ile Ile Thr Glu Lys Gly Glu Thr Gln Met Lys Arg Thr Met Ser 
                165                 170                 175     


Tyr Gly Lys Gly Asn Val Phe Ala Tyr Arg Thr Phe Leu Lys Pro Leu 
            180                 185                 190         


Thr Gly Val Lys Gln Ile Pro Glu Ser Ser Phe Ala Gly Arg Ser Asn 
        195                 200                 205             


Thr Val Val Gly Val Asp Val Thr Cys Glu Ile Gly Gly Glu Ala Phe 
    210                 215                 220                 


Leu Pro Ser Phe Thr Asp Gly Asp Asn Thr Leu Val Val Ala Thr Asp 
225                 230                 235                 240 


Ser Met Lys Asn Phe Ile Gln Arg His Leu Ala Ser Tyr Glu Gly Thr 
                245                 250                 255     


Thr Thr Glu Gly Phe Leu His Tyr Val Ala His Arg Phe Leu Asp Thr 
            260                 265                 270         


Tyr Ser His Met Asp Lys Ile Thr Leu Thr Gly Glu Asp Ile Pro Phe 
        275                 280                 285             


Glu Ala Met Pro Ala Tyr Glu Glu Lys Glu Leu Ser Thr Ser Arg Leu 
    290                 295                 300                 


Val Phe Arg Arg Ser Arg Asn Glu Arg Ser Arg Ser Val Leu Lys Ala 
305                 310                 315                 320 


Glu Arg Ser Gly Asn Thr Ile Thr Ile Thr Glu Gln Tyr Ser Glu Ile 
                325                 330                 335     


Met Asp Leu Gln Leu Val Lys Val Ser Gly Asn Ser Phe Val Gly Phe 
            340                 345                 350         


Ile Arg Asp Glu Tyr Thr Thr Leu Pro Glu Asp Gly Asn Arg Pro Leu 
        355                 360                 365             


Phe Val Tyr Leu Asn Ile Ser Trp Gln Tyr Glu Asn Thr Asn Asp Ala 
    370                 375                 380                 


Tyr Ala Phe Asp Pro Ser Arg Tyr Val Ala Ala Glu Gln Val Arg Asp 
385                 390                 395                 400 


Leu Ala Ser Thr Val Phe His Glu Leu Glu Thr Pro Ser Ile Gln Asn 
                405                 410                 415     


Leu Ile Tyr His Ile Gly Cys Arg Ile Leu Ala Arg Phe Pro Gln Leu 
            420                 425                 430         


Thr Asp Val Ser Phe Gln Ser Gln Asn His Thr Trp Asp Thr Val Val 
        435                 440                 445             


Glu Glu Ile Pro Gly Ser Lys Gly Lys Val Tyr Thr Glu Pro Arg Pro 
    450                 455                 460                 


Pro Tyr Gly Phe Gln His Phe Thr Val Thr Arg Glu Asp Ala Glu Lys 
465                 470                 475                 480 


Glu Lys Gln Lys Thr Ala Glu Lys Cys Arg Ser Leu Lys Ala 
                485                 490                 


<210>  7
<211>  305
<212>  PRT
<213>  Unknown

<220>
<223>  Zygosaccharomyces parabailii

<400>  7

Met Ser Tyr Leu Ala Asp Ser Thr Tyr Gly Lys Asp Asn Val Lys Phe 
1               5                   10                  15      


Leu Lys Val Lys Lys Asp Pro Ser Asn Pro Lys Leu Gln Gln Val Met 
            20                  25                  30          


Glu Ala Thr Val Lys Val Leu Leu Arg Gly Asn Phe Asp Val Ser Tyr 
        35                  40                  45              


Thr Glu Ala Asp Asn Ser Pro Ile Val Pro Thr Asp Thr Val Lys Asn 
    50                  55                  60                  


Thr Ile Leu Ile Leu Ala Arg Gln Asn Asp Thr Trp Pro Thr Glu Lys 
65                  70                  75                  80  


Phe Ala Ala Lys Leu Ala Leu His Phe Thr Gly Lys Tyr Ser His Val 
                85                  90                  95      


Ser Gly Val Ser Ile Lys Ile Tyr Gln Glu Arg Trp Val Lys Tyr Asp 
            100                 105                 110         


Val Asp Gly Arg Pro Ser Gln His Ser Phe Val His Gln Gly Pro Glu 
        115                 120                 125             


Lys Lys Ile Val Glu Leu Glu Tyr Asp Lys Val Asn Gly Pro Thr His 
    130                 135                 140                 


Tyr Lys Leu Ser Thr Ser Ile Lys Asp Leu Thr Val Leu Lys Ser Thr 
145                 150                 155                 160 


Asn Ser Met Phe Tyr Asp Tyr Asn Val Cys Glu Tyr Thr Thr Leu Lys 
                165                 170                 175     


Pro Thr Thr Asp Arg Val Leu Ser Thr Asp Ile Phe Ala Val Trp Asp 
            180                 185                 190         


Trp Ser Ala Ser Lys Leu Gly Pro Leu Thr Ala Ile Ala Ala Gly Ala 
        195                 200                 205             


Ser Asp Leu Val Phe Asp Lys Val Phe Asn Asp Ala Arg Asp Ile Thr 
    210                 215                 220                 


Leu Asp Ile Phe Ala Lys Glu Asn Ser Val Ser Val Gln Ala Thr Met 
225                 230                 235                 240 


Tyr Asn Met Gly Val Ala Ile Leu Ala Lys Ala Pro Gln Val Glu Tyr 
                245                 250                 255     


Val Ser Tyr Glu Leu Pro Asn Lys His Tyr Ile Leu Phe Asp Leu Lys 
            260                 265                 270         


Trp Phe Gln Gly Leu Ser Asn Asp Asn Glu Leu Phe Tyr Pro Ser Pro 
        275                 280                 285             


His Pro Asn Gly Leu Ile Arg Cys Lys Val Gly Arg Lys Thr Ser Lys 
    290                 295                 300                 


Leu 
305 


<210>  8
<211>  281
<212>  PRT
<213>  Unknown

<220>
<223>  Spirosoma sp. KCTC 42546

<400>  8

Met Lys Leu Thr Leu Lys Lys Asn Ala Tyr Gly Lys Asn Ala Val Asn 
1               5                   10                  15      


Leu Ser Lys Ile Ile Arg His Pro Asn Tyr His Glu Phe Arg Gln Ile 
            20                  25                  30          


Ser Val Asn Val Ser Leu Glu Gly Asp Phe Glu Thr Ala His Thr Leu 
        35                  40                  45              


Gly Asp Asn Ser Lys Ile Val Pro Thr Asp Thr Gln Lys Asn Thr Val 
    50                  55                  60                  


Tyr Ala Leu Ala Lys Glu His Phe Val Asp Ser Ile Glu Asn Phe Gly 
65                  70                  75                  80  


Leu Tyr Leu Ala Asn Tyr Phe Ile Thr Asn Asn Pro Gln Val Ser Gln 
                85                  90                  95      


Ala Thr Val His Ile Ile Glu His Pro Trp Ala Arg Met Ala Phe Asp 
            100                 105                 110         


Gly Glu Pro His His His Ala Tyr Val Gly Gly Gly Ser Glu Lys Arg 
        115                 120                 125             


Thr Thr Thr Leu Val Gln Thr Thr Glu Ala Ile Arg Val Thr Ser Gly 
    130                 135                 140                 


Ile Lys Asp Leu Leu Ile Leu Lys Thr Thr Asp Ser Gly Phe Glu Gly 
145                 150                 155                 160 


Tyr Val Lys Asp Gln Tyr Thr Thr Leu Lys Glu Thr Ala Asp Arg Ile 
                165                 170                 175     


Phe Ala Thr Gln Cys Glu Ala Asn Trp Val Tyr Thr Ser His Asn Leu 
            180                 185                 190         


Asp Phe Thr Ser Leu Phe Gly Lys Ile Arg Glu Thr Leu Leu Lys Thr 
        195                 200                 205             


Phe Ala His His Lys Ser Leu Ser Val Gln Gln Thr Leu Leu Ala Met 
    210                 215                 220                 


Gly Ser Ala Val Leu Glu Glu Asn Gln Glu Val Ser Glu Ile Ser Leu 
225                 230                 235                 240 


Ile Met Pro Asn Lys His His Ile Pro Phe Asn Leu Glu Gln Phe Gly 
                245                 250                 255     


Met Asp Asn Gln Asn Glu Ile Phe Ile Ala Thr Asp Glu Pro Tyr Gly 
            260                 265                 270         


Tyr Ile Thr Gly Thr Val Thr Arg Glu 
        275                 280     


<210>  9
<211>  574
<212>  PRT
<213>  Unknown

<220>
<223>  Aspergillus nidulans

<400>  9

Met Asp Asn Ser Ile His Ser Thr Asp Gly Pro Asp Ser Val Ile Pro 
1               5                   10                  15      


Asn Ser Asn Pro Lys Lys Thr Val Arg Gln Arg Val Arg Leu Leu Ala 
            20                  25                  30          


Arg His Leu Thr Thr Arg Glu Gly Leu Ile Gly Asp Tyr Asp Tyr Gly 
        35                  40                  45              


Phe Leu Phe Arg Pro Glu Leu Pro Phe Met Lys Lys Asp Pro Arg Ala 
    50                  55                  60                  


Pro Pro Phe Phe Gly Leu Asn Glu Lys Ile Pro Val Leu Leu Ala Phe 
65                  70                  75                  80  


Ile Leu Gly Leu Gln His Ala Leu Ala Met Leu Ala Gly Val Val Thr 
                85                  90                  95      


Pro Pro Leu Ile Ile Ser Ser Ser Leu Ser Leu Pro Ser Asp Leu Gln 
            100                 105                 110         


Gln Tyr Leu Val Ser Thr Ser Leu Ile Val Cys Gly Leu Leu Ser Met 
        115                 120                 125             


Val Gln Ile Thr Arg Phe His Ile Tyr Lys Thr Pro Tyr Tyr Ile Gly 
    130                 135                 140                 


Ser Gly Val Leu Ser Val Met Gly Val Ser Phe Ser Ile Ile Ser Val 
145                 150                 155                 160 


Ala Ser Gly Ala Phe Asn Gln Met Tyr Ser Asn Gly Phe Cys Gln Leu 
                165                 170                 175     


Asp Glu Ala Gly Asn Arg Leu Pro Cys Pro Glu Ala Tyr Gly Ala Leu 
            180                 185                 190         


Ile Gly Thr Ser Ala Cys Cys Ala Leu Val Glu Ile Leu Leu Ala Phe 
        195                 200                 205             


Val Pro Pro Lys Val Ile Gln Lys Ile Phe Pro Pro Ile Val Thr Gly 
    210                 215                 220                 


Pro Thr Val Met Leu Ile Gly Ile Ser Leu Ile Gly Thr Gly Phe Lys 
225                 230                 235                 240 


Asp Trp Ala Gly Gly Ser Ala Cys Met Asp Asp Gly Met Leu Cys Pro 
                245                 250                 255     


Ser Ala Thr Ala Pro Arg Pro Leu Pro Trp Gly Ser Pro Glu Phe Ile 
            260                 265                 270         


Gly Leu Gly Phe Leu Val Phe Val Ser Ile Ile Leu Cys Glu Arg Phe 
        275                 280                 285             


Gly Ala Pro Ile Met Lys Ser Cys Ser Val Val Ile Gly Leu Leu Val 
    290                 295                 300                 


Gly Cys Ile Val Ala Ala Ala Cys Gly Tyr Phe Ser His Ala Asp Ile 
305                 310                 315                 320 


Asp Ala Ala Pro Ala Ala Ser Phe Ile Trp Val Lys Thr Phe Pro Leu 
                325                 330                 335     


Ser Val Tyr Gly Pro Met Val Leu Pro Ile Ile Ala Val Phe Ile Ile 
            340                 345                 350         


Cys Ala Cys Glu Cys Ile Gly Asp Val Thr Ala Thr Cys Asp Val Ser 
        355                 360                 365             


Arg Leu Glu Val Arg Gly Gly Thr Phe Glu Ser Arg Ile Gln Gly Ala 
    370                 375                 380                 


Val Leu Ala Asp Gly Ile Asn Ser Val Val Ala Ala Leu Ala Thr Met 
385                 390                 395                 400 


Thr Pro Met Thr Thr Phe Ala Gln Asn Asn Gly Val Ile Ala Leu Thr 
                405                 410                 415     


Arg Cys Ala Asn Arg Trp Ala Gly Tyr Cys Cys Cys Leu Ile Leu Ile 
            420                 425                 430         


Val Ala Gly Ile Phe Ala Lys Phe Ala Ala Ala Ile Val Ala Ile Pro 
        435                 440                 445             


Asn Ser Val Met Gly Gly Met Lys Thr Phe Leu Phe Ala Ser Val Val 
    450                 455                 460                 


Ile Ser Gly Gln Ala Ile Val Ala Lys Ala Pro Phe Thr Arg Arg Asn 
465                 470                 475                 480 


Arg Phe Ile Leu Thr Ala Ser Met Ala Leu Gly Tyr Gly Ala Thr Leu 
                485                 490                 495     


Val Pro Thr Trp Phe Gly Asn Val Phe Pro Gln Thr Glu Asn Arg Asp 
            500                 505                 510         


Leu Glu Gly Phe Glu Asn Ala Ile Glu Leu Val Leu Glu Thr Gly Phe 
        515                 520                 525             


Ala Val Thr Ala Phe Val Ala Met Leu Leu Asn Ala Ile Met Pro Ala 
    530                 535                 540                 


Glu Val Glu Glu Ile Gly Ala Val Thr Pro Met Pro Val Ser Ala His 
545                 550                 555                 560 


Asp Asn Arg Asp Gly Glu Ala Glu Tyr Gln Ser Lys Gln Ala 
                565                 570                 


<210>  10
<211>  580
<212>  PRT
<213>  Unknown

<220>
<223>  Aspergillus nidulans

<400>  10

Met Asp Gly Pro Asp Gln Ile Gly Pro Asp Val Arg Pro Arg Arg Thr 
1               5                   10                  15      


Phe Gly Asp Arg Val Arg Arg Ala Ala Arg Ala Phe Thr Thr Arg Asp 
            20                  25                  30          


Gly Leu Ile Gly Asp Tyr Asp Tyr Gly Phe Leu Phe Thr Pro Arg Leu 
        35                  40                  45              


Pro Phe Val Lys Gln Lys Arg Arg Ala Ala Pro Phe Phe Gly Leu Glu 
    50                  55                  60                  


Asp Lys Ile Pro Leu Val Leu Ala Leu Leu Leu Gly Leu Gln His Ala 
65                  70                  75                  80  


Leu Ala Met Leu Ala Gly Val Ile Thr Pro Pro Ile Leu Leu Ala Gly 
                85                  90                  95      


Ser Ser Gly Ala Asn Phe Gly Ala Asp Glu Ser Gln Tyr Leu Val Ser 
            100                 105                 110         


Thr Ser Leu Ile Val Ser Gly Leu Leu Ser Ala Val Gln Met Phe Arg 
        115                 120                 125             


Leu His Val Tyr Lys Thr Arg Tyr Tyr Val Gly Thr Gly Leu Val Ser 
    130                 135                 140                 


Val Val Gly Thr Ser Phe Ala Thr Ile Thr Val Ala Thr Gly Thr Phe 
145                 150                 155                 160 


Asn Gln Met Tyr Ser Thr Gly Tyr Cys Pro Val Asp Gly Ser Gly Asn 
                165                 170                 175     


Arg Leu Pro Cys Pro Lys Gly Tyr Gly Ala Leu Leu Ala Thr Ser Cys 
            180                 185                 190         


Leu Cys Ser Leu Leu Glu Ile Gly Leu Ser Phe Met Ser Ser Arg Leu 
        195                 200                 205             


Leu Lys Ala Leu Phe Pro Pro Ile Val Thr Gly Pro Thr Val Phe Leu 
    210                 215                 220                 


Ile Gly Ala Ser Leu Ile Gly Asn Ala Met Lys Asp Trp Ala Gly Gly 
225                 230                 235                 240 


Ser Gly Thr Cys Ser Ser Asn Pro Gly Asn Gly Ala Leu Cys Pro Ser 
                245                 250                 255     


Ala Asp Ala Pro His Pro Leu Pro Trp Gly Ser Ala Glu Phe Ile Gly 
            260                 265                 270         


Leu Gly Phe Leu Val Phe Ala Thr Ile Ile Leu Cys Glu Arg Phe Gly 
        275                 280                 285             


Ser Pro Ile Met Lys Ser Cys Ala Val Ile Val Gly Leu Leu Val Gly 
    290                 295                 300                 


Cys Ile Val Ala Ala Ala Cys Gly Tyr Phe Asp Arg Ser Gly Ile Asp 
305                 310                 315                 320 


Ala Ala Pro Val Ala Ser Phe Ile Trp Val Lys Thr Phe Pro Leu Thr 
                325                 330                 335     


Ile Tyr Ala Pro Leu Ile Leu Pro Leu Leu Ala Val Tyr Met Val Ile 
            340                 345                 350         


Met Met Glu Ser Ile Gly Asp Ile Thr Ala Thr Cys Asp Val Ser Arg 
        355                 360                 365             


Leu Gln Val Glu Gly Ala Thr Phe Asp Ser Arg Ile Gln Gly Gly Val 
    370                 375                 380                 


Leu Gly Asn Gly Ile Thr Cys Leu Leu Ala Gly Leu Cys Thr Ile Thr 
385                 390                 395                 400 


Pro Met Ser Val Phe Ala Gln Asn Asn Gly Val Ile Ala Leu Thr Arg 
                405                 410                 415     


Cys Ala Asn Arg Lys Ala Gly Tyr Cys Cys Cys Phe Phe Leu Val Val 
            420                 425                 430         


Met Gly Ile Phe Ala Lys Phe Ala Ala Ala Leu Val Ala Ile Pro Ser 
        435                 440                 445             


Ser Val Leu Gly Gly Met Thr Thr Phe Leu Phe Ser Ser Val Ala Ile 
    450                 455                 460                 


Ser Gly Val Arg Ile Met Cys Ser Val Asp Trp Thr Arg Arg Asn Arg 
465                 470                 475                 480 


Phe Ile Leu Thr Ala Ser Phe Ala Val Gly Met Ala Ala Thr Leu Val 
                485                 490                 495     


Pro Asp Trp Phe Ser Tyr Phe Phe Thr Tyr Ser Gly Asp Asn His Ala 
            500                 505                 510         


Leu Glu Gly Leu Leu Gln Ala Val Glu Leu Val Met Ala Asn Gly Phe 
        515                 520                 525             


Ala Val Thr Gly Phe Leu Gly Leu Leu Leu Asn Leu Ile Leu Pro Glu 
    530                 535                 540                 


Asp Met Glu Glu Asp Val Val Glu Ser Glu Glu Asp Tyr Glu Ala Thr 
545                 550                 555                 560 


Thr Val Val Gly Met Gln Gly Gly Ser Glu Pro Gly Ser Ser Gly Gln 
                565                 570                 575     


Asn Val Lys Ala 
            580 


<210>  11
<211>  583
<212>  PRT
<213>  Unknown

<220>
<223>  Aspergillus fumigatus

<400>  11

Met Asp Gly Pro Asp Arg Ile Gly Pro Asp His Ser Pro Arg Arg Thr 
1               5                   10                  15      


Leu Arg Asp Lys Ala Arg Arg Leu Val Lys Thr Trp Thr Thr Lys Glu 
            20                  25                  30          


Gly Leu Val Gly Asp Tyr Asn Tyr Ala Tyr Leu Phe Thr Pro Arg Ile 
        35                  40                  45              


Pro Phe Thr Lys Asn Ile Arg Arg Thr Ala Pro Phe Phe Gly Leu His 
    50                  55                  60                  


Asp Arg Leu Pro Val Leu Leu Ala Phe Ile Leu Gly Leu Gln His Ala 
65                  70                  75                  80  


Leu Ala Met Leu Ala Gly Val Ile Ser Pro Pro Ile Ile Leu Gly Gly 
                85                  90                  95      


Ser Ser Gly Ala Asn Phe Gly Asp Ala Glu Tyr Gln Tyr Leu Val Ser 
            100                 105                 110         


Thr Ser Leu Ile Ala Ser Gly Leu Leu Ser Ala Val Gln Met Ala Arg 
        115                 120                 125             


Leu Arg Ile Trp Lys Thr Arg Tyr Phe Ile Gly Thr Gly Leu Ile Ser 
    130                 135                 140                 


Val Val Gly Thr Ser Phe Ser Thr Ile Thr Val Ala Ser Gly Thr Phe 
145                 150                 155                 160 


Ser Gln Met Tyr Ala Ser Gly Tyr Cys Pro Thr Asp Ala Asn Gly Asn 
                165                 170                 175     


Arg Leu Pro Cys Pro Arg Gly Tyr Gly Ala Ile Leu Gly Thr Ala Cys 
            180                 185                 190         


Leu Cys Ser Leu Leu Thr Ile Gly Leu Ser Phe Met Ser Pro Arg Ile 
        195                 200                 205             


Leu Lys Arg Ile Phe Pro Pro Met Val Thr Gly Pro Thr Val Leu Leu 
    210                 215                 220                 


Ile Gly Ala Ser Leu Ile Glu Ser Gly Met Lys Asp Trp Ala Gly Gly 
225                 230                 235                 240 


Ser Gly Cys Gly Ser Asp Pro Ser Ala Arg Ala Leu Cys Pro Ser Ala 
                245                 250                 255     


Gly Ala Pro His Ala Leu Pro Trp Gly Ser Ala Glu Phe Ile Gly Leu 
            260                 265                 270         


Gly Phe Leu Val Phe Val Thr Ile Ile Leu Cys Glu Arg Phe Gly Ser 
        275                 280                 285             


Pro Ile Met Lys Ser Cys Ala Val Val Val Gly Leu Leu Val Gly Cys 
    290                 295                 300                 


Ile Val Ala Ala Ala Cys Gly Tyr Phe Asp Arg Ser Gly Ile Asp Ser 
305                 310                 315                 320 


Ala Pro Val Val Ser Phe Ile Trp Val Lys Thr Phe Pro Leu Thr Ile 
                325                 330                 335     


Tyr Ala Pro Leu Ile Leu Pro Phe Leu Ala Leu Tyr Ile Val Ile Met 
            340                 345                 350         


Met Glu Ser Ile Gly Asp Ile Thr Ala Thr Cys Asp Val Ser Gln Leu 
        355                 360                 365             


Glu Val Glu Gly Ala Asp Phe Asp Ser Arg Val Gln Gly Gly Val Leu 
    370                 375                 380                 


Gly Asn Gly Leu Thr Cys Leu Leu Ala Gly Leu Phe Thr Ile Thr Pro 
385                 390                 395                 400 


Met Ser Val Phe Ala Gln Asn Asn Gly Val Ile Ala Leu Thr Lys Cys 
                405                 410                 415     


Ala Asn Arg Lys Ala Gly Tyr Cys Cys Cys Phe Phe Leu Val Val Met 
            420                 425                 430         


Gly Val Phe Ala Lys Phe Ala Ala Ala Ile Val Ala Ile Pro Lys Pro 
        435                 440                 445             


Val Leu Gly Gly Met Thr Thr Phe Leu Phe Ser Ser Val Ala Ile Ser 
    450                 455                 460                 


Gly Ile Arg Ile Ile Ser Thr Ile Pro Phe Thr Arg Arg Asn Arg Phe 
465                 470                 475                 480 


Ile Leu Thr Ala Ser Phe Ala Val Gly Met Ala Ala Thr Leu Val Pro 
                485                 490                 495     


Asp Trp Phe Ser Tyr Phe Phe Thr Tyr Ser Gly Asp Asn His Ala Leu 
            500                 505                 510         


Glu Gly Leu Leu Asn Ala Val Glu Leu Val Met Glu Asn Gly Phe Ala 
        515                 520                 525             


Ile Thr Ala Val Ile Gly Leu Val Leu Asn Leu Val Leu Pro Glu Asp 
    530                 535                 540                 


Pro Glu Asp Glu Ala Ala Ile Val Glu Ala Thr Ala Arg Asp Ala Pro 
545                 550                 555                 560 


Thr Glu Glu Leu Lys Asp Ser Asp Pro Ser Ser Leu Lys Ala Gly Gln 
                565                 570                 575     


Pro Ser Gly Ser Leu Ala Val 
            580             


<210>  12
<211>  591
<212>  PRT
<213>  Candida albicans

<400>  12

Met Ser Ala Ile Gln Lys Thr Leu Lys Arg Met Val Arg Lys Trp Thr 
1               5                   10                  15      


Thr Lys Asp Gly Leu Leu Gly Asp Tyr Asp Tyr Lys Tyr Leu Phe Thr 
            20                  25                  30          


Pro Asp Ile Pro Phe Ile Thr Lys Glu Leu Lys Thr Gln Pro Phe Phe 
        35                  40                  45              


Gly Val Asp Thr Asp Met Pro Ile Leu Leu Gly Ala Ile Leu Gly Phe 
    50                  55                  60                  


Gln His Ala Leu Ala Met Leu Ala Gly Ile Val Thr Val Pro Ile Met 
65                  70                  75                  80  


Val Ala Ser Thr Ala Asn Leu Ser Val Glu Ile Glu Gln Tyr Leu Val 
                85                  90                  95      


Ser Thr Ser Ser Ile Val Ser Gly Val Leu Ser Leu Ile Gln Ile Thr 
            100                 105                 110         


Arg Phe His Ile Pro Lys Thr Pro Tyr Tyr Ile Gly Thr Gly Leu Leu 
        115                 120                 125             


Ser Val Val Gly Thr Ser Phe Ala Thr Ile Thr Ile Val Thr Lys Ala 
    130                 135                 140                 


Phe Pro Met Met Tyr Ala Asp Gly Thr Cys Pro Met Ala Ser Asp Gly 
145                 150                 155                 160 


Val Thr Lys Leu Pro Cys Pro Asp Gly Tyr Gly Lys Ile Leu Ala Ser 
                165                 170                 175     


Ala Cys Cys Cys Ala Leu Leu Glu Ile Leu Leu Ser Phe Met Lys Pro 
            180                 185                 190         


Ser Met Leu Gln Lys Ile Phe Pro Pro Leu Val Thr Gly Pro Val Val 
        195                 200                 205             


Met Leu Ile Gly Val His Leu Val Glu Ser Gly Phe Thr Asp Trp Val 
    210                 215                 220                 


Gly Gly Ala Gly Cys Gln Asp Ser Asp Thr Cys Thr Tyr Gly Lys Phe 
225                 230                 235                 240 


Ser Ala Pro Trp Gly Asp Ala Lys Phe Ile Gly Leu Gly Phe Leu Val 
                245                 250                 255     


Tyr Val Ser Ile Ile Leu Ala Glu Arg Phe Gly Ala Pro Ile Met Lys 
            260                 265                 270         


Ser Cys Ala Val Ile Phe Gly Leu Leu Ile Gly Cys Ile Val Ala Ala 
        275                 280                 285             


Ala Ala Gly Tyr Phe Ser Ser Asp Asn Val Asp Ala Ala Pro Ala Ala 
    290                 295                 300                 


Ser Phe Met Trp Val His Thr Phe Lys Leu Thr Val Tyr Gly Pro Val 
305                 310                 315                 320 


Val Leu Pro Phe Leu Ala Val Tyr Ile Val Leu Met Met Glu Cys Ile 
                325                 330                 335     


Gly Asp Val Thr Ala Thr Ser Asp Val Ser Arg Leu Pro Val Ser Gly 
            340                 345                 350         


Glu Met Tyr Glu Ser Arg Ile Gln Gly Gly Val Leu Gly Asp Gly Ile 
        355                 360                 365             


Cys Gly Ile Leu Ser Thr Leu Met Thr Met Thr Pro Met Ser Val Phe 
    370                 375                 380                 


Ala Gln Asn Asn Gly Val Ile Ser Ile Thr Lys Cys Ala Asn Arg Lys 
385                 390                 395                 400 


Val Gly Tyr Trp Cys Ala Phe Phe Leu Ile Val Met Gly Val Phe Ala 
                405                 410                 415     


Lys Phe Ala Gly Ala Ile Thr Ser Ile Pro Lys Pro Val Leu Gly Gly 
            420                 425                 430         


Met Thr Ser Phe Leu Phe Cys Ser Val Ala Ile Ser Gly Ile Lys Ile 
        435                 440                 445             


Ile Ser Thr Thr Glu Phe Thr Arg Arg Asp Arg Phe Val Leu Thr Ala 
    450                 455                 460                 


Ala Val Ser Pro Gly Leu Gly Ala Thr Met Leu Pro Asn Trp Phe Glu 
465                 470                 475                 480 


His Val Phe Thr Tyr Gln Gly Gly Asn Lys Ser Leu Lys Gly Phe Phe 
                485                 490                 495     


Asn Ala Ile Ile Val Val Val Glu Ser Gly Phe Cys Leu Ser Gly Val 
            500                 505                 510         


Ile Ala Val Ile Leu Asn Leu Leu Ile Pro Gln Val Glu Asp Asp Val 
        515                 520                 525             


Glu Glu Ile Asn Glu Leu Val Leu Asp Val Val Gly Ser Ala Thr Glu 
    530                 535                 540                 


Ser Ala Arg Gln Lys Phe Glu Glu Lys Glu Gly Val Lys Leu Glu Ala 
545                 550                 555                 560 


Leu Arg Ser Gln Leu Ser Asn Ile Lys Ser Asn Gly Gly Ser Arg Asp 
                565                 570                 575     


Ala Ile Thr Val Leu His Arg Asn Asp Gly Phe Pro Asp Leu Lys 
            580                 585                 590     


<210>  13
<211>  601
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  13

Met Ser Glu Ser Ile Gln Asp Gln Asp His Glu Lys Thr Thr Ile Ile 
1               5                   10                  15      


Glu Lys Thr Arg Arg Phe Val Leu Ser Ile Phe Thr Lys Asp Phe Trp 
            20                  25                  30          


Ile Gly Asp Tyr Asp Tyr Ser Phe Leu Leu Pro Ala Ile Pro Phe Thr 
        35                  40                  45              


Lys Gln Lys Pro Lys Ser Pro Pro Phe Phe Ser Leu Asn Ala Lys Val 
    50                  55                  60                  


Pro Val Leu Leu Ala Leu Leu Leu Gly Phe Gln His Ala Leu Ala Met 
65                  70                  75                  80  


Val Gly Gly Val Thr Ser Pro Pro Arg Ile Ile Ala Ala Ser Ala Asn 
                85                  90                  95      


Leu Thr Thr Glu Gln Thr Asn Tyr Leu Val Ser Ala Gly Leu Ile Ser 
            100                 105                 110         


Ser Gly Ile Met Thr Leu Ile Gln Ile Ala Arg Val His Ile Pro Lys 
        115                 120                 125             


Thr Lys Tyr Tyr Ile Gly Thr Gly Met Leu Ser Val Leu Gly Ile Ser 
    130                 135                 140                 


Phe Thr Ser Val Ser Val Ala Pro Lys Val Leu Ser Gln Met Tyr Glu 
145                 150                 155                 160 


Asn Gly Tyr Cys Pro Lys Asp Glu Asn Gly Thr Lys Leu Pro Cys Pro 
                165                 170                 175     


Asp Gly Tyr Gly Ala Phe Leu Ala Thr Ala Cys Val Cys Ser Leu Leu 
            180                 185                 190         


Glu Ile Phe Met Ser Phe Ile Pro Pro Arg Ile Leu Lys Arg Leu Phe 
        195                 200                 205             


Pro Pro Ile Val Thr Gly Pro Val Val Leu Leu Ile Gly Thr Ser Leu 
    210                 215                 220                 


Ile Ser Ser Gly Leu Asn Asp Trp Ala Gly Gly Glu Gly Ser Cys Thr 
225                 230                 235                 240 


Gly Arg Pro Thr Glu Ala Glu Ala Pro Gly Tyr Ser Leu Cys Pro Ser 
                245                 250                 255     


Asp Thr Ser Pro His Ala Leu Gly Trp Gly Ser Ala Gln Phe Ile Gly 
            260                 265                 270         


Leu Gly Phe Ser Val Phe Ala Thr Ile Ile Ile Ile Glu Arg Phe Gly 
        275                 280                 285             


Pro Pro Leu Met Lys Thr Thr Ser Val Val Leu Gly Leu Val Val Gly 
    290                 295                 300                 


Met Ile Ile Ser Ala Ala Thr Gly Tyr Trp Asp His Ser Ile Ile Asp 
305                 310                 315                 320 


Ala Ala Pro Val Val Thr Phe Asn Trp Val His Thr Phe Arg Leu Arg 
                325                 330                 335     


Ile Tyr Gly Pro Ala Val Leu Pro Met Leu Ala Leu Tyr Ile Val Asn 
            340                 345                 350         


Met Met Glu Ala Ile Gly Asp Ile Gly Ala Thr Ser Asp Val Ser Met 
        355                 360                 365             


Leu Glu Val Asp Gly Pro Ala Phe Asp Ala Arg Val Gln Gly Gly Ile 
    370                 375                 380                 


Leu Gly Asp Gly Leu Ala Ser Leu Ile Ala Ser Leu Met Thr Thr Thr 
385                 390                 395                 400 


Pro Leu Thr Thr Phe Ala Gln Asn Asn Gly Val Ile Ser Leu Thr Lys 
                405                 410                 415     


Cys Ala Asn Arg Arg Ala Gly Phe Phe Cys Ala Val Ile Leu Phe Phe 
            420                 425                 430         


Met Gly Leu Phe Ala Lys Phe Ala Ala Val Phe Val Ala Ile Pro Ser 
        435                 440                 445             


Pro Val Leu Gly Gly Met Thr Thr Phe Leu Phe Ser Ser Val Ala Val 
    450                 455                 460                 


Ser Gly Ile Ala Ile Ile Ser Gln Ile Pro Phe Asn Arg Arg Asn Arg 
465                 470                 475                 480 


Phe Ile Leu Thr Ala Ser Met Thr Leu Gly Met Gly Ala Ile Leu Val 
                485                 490                 495     


Pro Asp Trp Phe Thr Tyr Phe Phe Glu Tyr Ser Gly Pro Asn Lys Ala 
            500                 505                 510         


Leu Val Gly Phe Leu Asp Ala Ile Thr Leu Val Met Glu Asn Gly Phe 
        515                 520                 525             


Ala Ile Gly Ala Phe Ile Ser Ile Phe Leu Asn Leu Ile Leu Pro Tyr 
    530                 535                 540                 


Glu Phe Asp Pro Asp Leu Thr Asn Asp Ser Pro Gly Leu Ser Thr Thr 
545                 550                 555                 560 


Asn Gly Val Asn Asn Gly Ile Val Glu Val Arg Gly Ile Asp Pro Asn 
                565                 570                 575     


Asp Ser Leu Ser Asn Thr Asp Thr Glu Tyr Ala Asn Glu Asn Lys Lys 
            580                 585                 590         


Asp Glu Val Asp Val Asp Lys Val Val 
        595                 600     


<210>  14
<211>  430
<212>  PRT
<213>  Bacillus subtilis

<400>  14

Met Lys Glu Gln His Asn Ala Leu Gln Leu Met Met Leu Gly Leu Gln 
1               5                   10                  15      


His Met Leu Ala Met Tyr Ala Gly Ala Ile Leu Val Pro Leu Ile Val 
            20                  25                  30          


Gly Ala Ala Ile Gly Leu Asn Ala Gly Gln Leu Thr Tyr Leu Ile Ala 
        35                  40                  45              


Ile Asp Leu Phe Met Cys Gly Ala Ala Thr Leu Leu Gln Leu Trp Arg 
    50                  55                  60                  


Asn Arg Tyr Phe Gly Ile Gly Leu Pro Val Val Leu Gly Cys Thr Phe 
65                  70                  75                  80  


Thr Ala Val Gly Pro Met Ile Ser Ile Gly Ser Thr Tyr Gly Val Pro 
                85                  90                  95      


Ala Ile Tyr Gly Ala Ile Ile Ala Ala Gly Leu Ile Val Val Leu Ala 
            100                 105                 110         


Ala Gly Phe Phe Gly Lys Leu Val Arg Phe Phe Pro Pro Val Val Thr 
        115                 120                 125             


Gly Ser Val Val Met Ile Ile Gly Ile Ser Leu Ile Pro Thr Ala Met 
    130                 135                 140                 


Asn Asn Leu Ala Gly Gly Glu Gly Ser Lys Glu Phe Gly Ser Leu Asp 
145                 150                 155                 160 


Asn Val Leu Leu Gly Phe Gly Val Thr Ala Phe Ile Leu Leu Leu Phe 
                165                 170                 175     


Tyr Phe Phe Lys Gly Phe Ile Arg Ser Ile Ala Ile Leu Leu Gly Leu 
            180                 185                 190         


Ile Ala Gly Thr Ala Ala Ala Tyr Phe Met Gly Lys Val Asp Phe Ser 
        195                 200                 205             


Glu Val Leu Glu Ala Ser Trp Leu His Val Pro Ser Leu Phe Tyr Phe 
    210                 215                 220                 


Gly Pro Pro Thr Phe Glu Leu Pro Ala Val Val Thr Met Leu Leu Val 
225                 230                 235                 240 


Ala Ile Val Ser Leu Val Glu Ser Thr Gly Val Tyr Phe Ala Leu Ala 
                245                 250                 255     


Asp Ile Thr Asn Arg Arg Leu Ser Glu Lys Asp Leu Glu Lys Gly Tyr 
            260                 265                 270         


Arg Ala Glu Gly Leu Ala Ile Leu Leu Gly Gly Leu Phe Asn Ala Phe 
        275                 280                 285             


Pro Tyr Thr Ala Phe Ser Gln Asn Val Gly Ile Val Gln Leu Ser Lys 
    290                 295                 300                 


Met Lys Ser Val Asn Val Ile Ala Ile Thr Gly Ile Ile Leu Val Ala 
305                 310                 315                 320 


Ile Gly Leu Val Pro Lys Ala Ala Ala Leu Thr Thr Val Ile Pro Thr 
                325                 330                 335     


Pro Val Leu Gly Gly Ala Met Ile Val Met Phe Gly Met Val Ile Ser 
            340                 345                 350         


Tyr Gly Ile Lys Met Leu Ser Ser Val Asp Leu Asp Ser Gln Gly Asn 
        355                 360                 365             


Leu Leu Ile Ile Ala Ser Ser Val Ser Leu Gly Leu Gly Ala Thr Thr 
    370                 375                 380                 


Val Pro Ala Leu Phe Ser Ser Leu Ser Gly Ala Ala Ser Val Leu Ala 
385                 390                 395                 400 


Gly Ser Gly Ile Val Ile Gly Ser Leu Thr Ala Ile Ala Leu His Ala 
                405                 410                 415     


Phe Phe Gln Thr Lys Gln Pro Asn Ser Ala Asp Ile Lys Thr 
            420                 425                 430 


<210>  15
<211>  450
<212>  PRT
<213>  Bacillus subtilis

<400>  15

Met Val Lys Lys Arg Ser Phe Lys Val Phe Thr Leu Gly Leu Gln His 
1               5                   10                  15      


Val Leu Ala Met Tyr Ala Gly Ala Ile Leu Val Pro Leu Leu Val Gly 
            20                  25                  30          


Arg Ala Leu Asn Val Thr Thr Glu Gln Leu Ser Tyr Leu Leu Ala Ile 
        35                  40                  45              


Asp Leu Leu Thr Cys Gly Val Ala Thr Leu Leu Gln Thr Leu Arg Gly 
    50                  55                  60                  


Ala Tyr Ile Gly Ile Gly Leu Pro Val Met Leu Gly Ser Ser Phe Val 
65                  70                  75                  80  


Ala Val Thr Pro Met Ile Ala Ile Gly Ser Asn Tyr Gly Ile His Ala 
                85                  90                  95      


Ile Tyr Gly Ser Ile Ile Ala Ala Gly Val Phe Ile Phe Leu Phe Ala 
            100                 105                 110         


Arg Phe Phe Gly Lys Leu Thr Val Leu Phe Pro Pro Val Val Thr Gly 
        115                 120                 125             


Thr Val Val Thr Leu Ile Gly Leu Ser Leu Val Pro Thr Gly Val Lys 
    130                 135                 140                 


Asn Met Ala Gly Gly Glu Lys Ile Asn Gly Ser Ala Asn Pro Glu Tyr 
145                 150                 155                 160 


Gly Ser Leu Glu Asn Leu Leu Leu Ser Val Gly Val Leu Val Leu Ile 
                165                 170                 175     


Leu Val Leu Asn Arg Phe Leu Lys Gly Phe Ala Arg Thr Leu Ser Val 
            180                 185                 190         


Leu Ile Gly Ile Ala Ala Gly Thr Ala Ala Ala Ala Ile Met Gly Lys 
        195                 200                 205             


Val Ser Phe Ser Ser Val Thr Glu Ala Pro Phe Phe Gln Ile Pro Lys 
    210                 215                 220                 


Pro Phe Tyr Phe Gly Ala Pro Thr Phe Glu Ile Gly Pro Ile Leu Thr 
225                 230                 235                 240 


Met Leu Ile Val Gly Ile Val Ile Ile Val Glu Ser Thr Gly Val Phe 
                245                 250                 255     


Tyr Ala Ile Gly Lys Ile Cys Gly Arg Pro Leu Thr Glu Lys Asp Leu 
            260                 265                 270         


Val Lys Gly Tyr Arg Ala Glu Gly Ile Ala Ile Leu Ile Gly Gly Leu 
        275                 280                 285             


Phe Asn Ala Phe Pro Tyr Asn Thr Phe Ala Gln Asn Ala Gly Leu Leu 
    290                 295                 300                 


Gln Leu Thr Lys Val Lys Thr Arg Asn Ile Val Val Thr Ala Gly Cys 
305                 310                 315                 320 


Ile Leu Val Cys Leu Gly Leu Ile Pro Lys Ile Ala Ala Leu Ala Ser 
                325                 330                 335     


Ala Val Pro Ala Ala Val Leu Gly Gly Ala Thr Val Val Met Phe Gly 
            340                 345                 350         


Met Val Ile Ala Ser Gly Val Lys Met Leu Ser Thr Ala Asp Leu Lys 
        355                 360                 365             


Asn Gln Tyr His Leu Leu Thr Ile Ala Cys Ser Ile Ala Leu Gly Ile 
    370                 375                 380                 


Gly Ala Ser Thr Ala Pro Gly Ile Phe Ala Glu Phe Pro Ala Pro Ile 
385                 390                 395                 400 


Arg Ile Leu Val Ser Asp Gly Thr Ile Thr Gly Ser Leu Thr Ala Ile 
                405                 410                 415     


Phe Leu Asn Leu Phe Phe Ser Leu Arg Asp Lys Lys Glu Leu Thr Ala 
            420                 425                 430         


Gln Gln Thr Glu Leu Pro Val Leu Glu His Thr Leu Ala Leu Glu Lys 
        435                 440                 445             


Glu Val 
    450 


<210>  16
<211>  525
<212>  PRT
<213>  Escherichia coli

<400>  16

Met Pro Pro Gln Phe Leu Ser Leu Thr Pro Leu Pro Arg Lys Asn Trp 
1               5                   10                  15      


His Ser Thr Ser Met Cys Leu Asp Ser Phe Met Asn Ile Asn Gly Cys 
            20                  25                  30          


Phe Leu Leu Trp Arg Ala Lys Gly Glu Thr Leu Met Asn Ala Ile Asp 
        35                  40                  45              


Ser Gln Leu Pro Ser Ser Ser Gly Gln Asp Arg Pro Thr Asp Glu Val 
    50                  55                  60                  


Asp Arg Ile Leu Ser Pro Gly Lys Leu Ile Ile Leu Gly Leu Gln His 
65                  70                  75                  80  


Val Leu Val Met Tyr Ala Gly Ala Val Ala Val Pro Leu Met Ile Gly 
                85                  90                  95      


Asp Arg Leu Gly Leu Ser Lys Glu Ala Ile Ala Met Leu Ile Ser Ser 
            100                 105                 110         


Asp Leu Phe Cys Cys Gly Ile Val Thr Leu Leu Gln Cys Ile Gly Ile 
        115                 120                 125             


Gly Arg Phe Met Gly Ile Arg Leu Pro Val Ile Met Ser Val Thr Phe 
    130                 135                 140                 


Ala Ala Val Thr Pro Met Ile Ala Ile Gly Met Asn Pro Asp Ile Gly 
145                 150                 155                 160 


Leu Leu Gly Ile Phe Gly Ala Thr Ile Ala Ala Gly Phe Ile Thr Thr 
                165                 170                 175     


Leu Leu Ala Pro Leu Ile Gly Arg Leu Met Pro Leu Phe Pro Pro Leu 
            180                 185                 190         


Val Thr Gly Val Val Ile Thr Ser Ile Gly Leu Ser Ile Ile Gln Val 
        195                 200                 205             


Gly Ile Asp Trp Ala Ala Gly Gly Lys Gly Asn Pro Gln Tyr Gly Asn 
    210                 215                 220                 


Pro Val Tyr Leu Gly Ile Ser Phe Ala Val Leu Ile Phe Ile Leu Leu 
225                 230                 235                 240 


Ile Thr Arg Tyr Ala Lys Gly Phe Met Ser Asn Val Ala Val Leu Leu 
                245                 250                 255     


Gly Ile Val Phe Gly Phe Leu Leu Ser Trp Met Met Asn Glu Val Asn 
            260                 265                 270         


Leu Ser Gly Leu His Asp Ala Ser Trp Phe Ala Ile Val Thr Pro Met 
        275                 280                 285             


Ser Phe Gly Met Pro Ile Phe Asp Pro Val Ser Ile Leu Thr Met Thr 
    290                 295                 300                 


Ala Val Leu Ile Ile Val Phe Ile Glu Ser Met Gly Met Phe Leu Ala 
305                 310                 315                 320 


Leu Gly Glu Ile Val Gly Arg Lys Leu Ser Ser His Asp Ile Ile Arg 
                325                 330                 335     


Gly Leu Arg Val Asp Gly Val Gly Thr Met Ile Gly Gly Thr Phe Asn 
            340                 345                 350         


Ser Phe Pro His Thr Ser Phe Ser Gln Asn Val Gly Leu Val Ser Val 
        355                 360                 365             


Thr Arg Val His Ser Arg Trp Val Cys Ile Ala Ser Gly Ile Ile Leu 
    370                 375                 380                 


Ile Leu Phe Gly Met Val Pro Lys Met Ala Val Leu Val Ala Ser Ile 
385                 390                 395                 400 


Pro Gln Phe Val Leu Gly Gly Ala Gly Leu Val Met Phe Gly Met Val 
                405                 410                 415     


Leu Ala Thr Gly Ile Arg Ile Leu Ser Arg Cys Asn Tyr Thr Thr Asn 
            420                 425                 430         


Arg Tyr Asn Leu Tyr Ile Val Ala Ile Ser Leu Gly Val Gly Met Thr 
        435                 440                 445             


Pro Thr Leu Ser His Asp Phe Phe Ser Lys Leu Pro Ala Val Leu Gln 
    450                 455                 460                 


Pro Leu Leu His Ser Gly Ile Met Leu Ala Thr Leu Ser Ala Val Val 
465                 470                 475                 480 


Leu Asn Val Phe Phe Asn Gly Tyr Gln His His Ala Asp Leu Val Lys 
                485                 490                 495     


Glu Ser Val Ser Asp Lys Asp Leu Lys Val Arg Thr Val Arg Met Trp 
            500                 505                 510         


Leu Leu Met Arg Lys Leu Lys Lys Asn Glu His Gly Glu 
        515                 520                 525 


<210>  17
<211>  594
<212>  PRT
<213>  Unknown

<220>
<223>  zygosaccharomyces parabailii

<400>  17

Met Asp Ser Val Leu Glu Gln Pro Thr Asn Ser Pro Ser Gln Lys Ile 
1               5                   10                  15      


Lys Gly Tyr Phe Ser Trp Leu Arg Phe Lys Phe Thr Thr Arg Asp Gly 
            20                  25                  30          


Leu Leu Gly Asp Tyr Asp Tyr Lys Tyr Leu Phe Thr Pro Ser Tyr Pro 
        35                  40                  45              


Phe His Asp Phe Ile Cys Arg Leu Arg Gly Val Glu Val Val Val Arg 
    50                  55                  60                  


Asp Gln Pro Phe Phe Gly Leu Asn Glu Glu Val Pro Val Leu Leu Gly 
65                  70                  75                  80  


Met Ile Leu Gly Phe Gln His Ala Leu Ala Met Leu Ala Gly Val Ile 
                85                  90                  95      


Thr Pro Pro Met Met Ile Ala Ser Ala Ala Asn Leu Asp Ser Val Leu 
            100                 105                 110         


Thr Asn Tyr Leu Val Ser Ala Ser Leu Ile Thr Ser Gly Ile Leu Ser 
        115                 120                 125             


Ala Val Gln Ile Thr Arg Phe His Ile Pro Lys Thr Asn Tyr Tyr Ile 
    130                 135                 140                 


Gly Ser Gly Val Leu Ser Ile Val Gly Thr Ser Phe Ala Val Leu Gly 
145                 150                 155                 160 


Ile Val Asp Lys Ser Val Pro Leu Met Tyr Ser Thr Gly Tyr Cys Pro 
                165                 170                 175     


Gly Gly Ala Asn Ser Lys Glu Ala Cys Pro Asp Gly Tyr Gly Ala Leu 
            180                 185                 190         


Leu Gly Thr Ala Ala Cys Cys Ala Leu Leu Glu Met Leu Leu Ser Phe 
        195                 200                 205             


Thr Pro Pro His Ile Leu Gln Lys Ile Phe Pro Lys Gln Val Thr Gly 
    210                 215                 220                 


Pro Val Val Leu Thr Ile Ala Val Pro Leu Ile Gln Ser Gly Phe Glu 
225                 230                 235                 240 


Asp Trp Val Gly Gly Ser Gly Cys Val Gly Ala Ile Cys Pro Ser Glu 
                245                 250                 255     


Gly Ala Pro Gln Ala Ala Pro Trp Gly Ser Ala Lys Phe Ile Gly Leu 
            260                 265                 270         


Gly Phe Leu Val Tyr Thr Thr Ile Ile Leu Cys Glu Lys Tyr Gly Pro 
        275                 280                 285             


Pro Ile Leu Lys Ser Cys Ala Val Ile Val Gly Leu Leu Val Gly Cys 
    290                 295                 300                 


Ile Val Ala Ala Ala Cys Gly Tyr Phe Gln His Asp Met Ile Asp Val 
305                 310                 315                 320 


Ala Pro Ala Ala Thr Phe Leu Trp Lys His Thr Phe Arg Leu Arg Val 
                325                 330                 335     


Tyr Gly Pro Ala Val Leu Pro Phe Leu Val Met Phe Ile Val Leu Ala 
            340                 345                 350         


Gln Glu Cys Ile Gly Asp Ile Thr Ala Thr Ser Asp Val Ser Arg Leu 
        355                 360                 365             


Glu Val Glu Gly Glu Ala Tyr Glu Ser Arg Ile Gln Gly Ala Val Leu 
    370                 375                 380                 


Ser Asp Gly Ile Gly Gly Ile Leu Ser Ser Leu Phe Thr Val Thr Pro 
385                 390                 395                 400 


Met Ser Thr Phe Ala Gln Asn Asn Gly Val Ile Ser Leu Thr Lys Cys 
                405                 410                 415     


Ala Ser Arg Gln Ala Gly Tyr Trp Thr Cys Phe Tyr Met Leu Ile Met 
            420                 425                 430         


Gly Ile Phe Ala Lys Phe Gly Ala Ala Ile Val Gln Ile Pro Lys Pro 
        435                 440                 445             


Val Leu Gly Gly Met Thr Thr Phe Leu Phe Thr Thr Val Ala Val Ala 
    450                 455                 460                 


Gly Ile Lys Ile Ile Ser Glu Ile Pro Phe Thr Arg Arg Asp Arg Phe 
465                 470                 475                 480 


Val Leu Thr Gly Ala Leu Leu Pro Gly Phe Gly Ser Ile Leu Val Ser 
                485                 490                 495     


Asp Trp Phe Asp Tyr Val Phe Thr Tyr Lys Gly Asn Asn His Ala Leu 
            500                 505                 510         


Glu Gly Phe Phe Asn Ala Ile Ile Leu Ile Met Glu Thr Ser Phe Thr 
        515                 520                 525             


Val Cys Gly Leu Thr Ala Ile Ile Leu Asn Leu Leu Ile Pro Gln Glu 
    530                 535                 540                 


Leu Asp Glu Glu Leu Leu Asp Asp Ile Glu Val Gln Gln Glu Asn Leu 
545                 550                 555                 560 


Ser Val Leu Glu Gly Arg Lys Ser Pro Leu Ile Gly Pro Val Met Ser 
                565                 570                 575     


Gly Lys Glu Ile Glu Ala Phe Glu Leu Ser Ser Glu Gln Arg Thr Ser 
            580                 585                 590         


Asp Pro 
        


<210>  18
<211>  451
<212>  PRT
<213>  Unknown

<220>
<223>  Spirosoma sp. KCTC 42546

<400>  18

Met Ser Glu Pro Val Asn Ala Gln Ser Thr Arg Leu Val Tyr Gly Leu 
1               5                   10                  15      


Glu Asp Lys Val Pro Leu Val Pro Ala Leu Leu Val Ser Leu Gln Gln 
            20                  25                  30          


Val Gly Ala Met Val Val Gly Thr Ile Thr Pro Ala Leu Ile Leu Ser 
        35                  40                  45              


Gly Ile Leu His Phe Asp Pro Gln Asp Thr Ala Tyr Leu Val Ser Met 
    50                  55                  60                  


Ala Leu Val Ala Ser Ala Leu Gly Thr Phe Leu Gln Thr Met Arg Leu 
65                  70                  75                  80  


Gly Phe Ile Gly Ser Gly Leu Leu Ser Ile Thr Gly Thr Ser Phe Ala 
                85                  90                  95      


Phe Leu Ala Pro Leu Ile Gln Ala Gly Val Thr Gly Gly Leu Pro Leu 
            100                 105                 110         


Met Val Gly Met Ser Leu Ala Gly Thr Pro Val Gln Leu Ala Leu Ala 
        115                 120                 125             


Pro Phe Leu Pro Lys Leu Lys Arg Val Phe Thr Pro Leu Val Ser Gly 
    130                 135                 140                 


Ile Val Val Leu Leu Ile Gly Leu Ser Leu Ile Pro Thr Gly Met Arg 
145                 150                 155                 160 


Ser Ile Ala Gln Leu Pro Ala Glu Gly Ala Pro Ala Trp Ser Gly Gly 
                165                 170                 175     


Leu Val Ala Leu Ile Val Ile Val Val Met Ile Ile Ala Gln Ser Ile 
            180                 185                 190         


Gly Lys Ala Trp Ala Arg Met Ala Ala Val Leu Val Gly Val Val Thr 
        195                 200                 205             


Gly Tyr Thr Ile Cys Gly Leu Met Gly Trp Leu Gln Ser Pro Ala Pro 
    210                 215                 220                 


Ser Asn Gly Ser Trp Leu Thr Leu Pro Gln Leu Phe Pro Tyr Gly Leu 
225                 230                 235                 240 


Ala Phe Lys Trp Glu Leu Leu Phe Pro Phe Ala Phe Ile Tyr Leu Val 
                245                 250                 255     


Cys Val Leu Glu Ala Met Gly Asp Ile Thr Ala Thr Ser Gln Leu Ser 
            260                 265                 270         


Gly Leu Pro Thr Asp Gly Pro Asp His Trp Ala Arg Ile Arg Gly Gly 
        275                 280                 285             


Ile Leu Ala Asp Gly Leu Thr Cys Ile Gly Ser Thr Leu Ile Gly Gly 
    290                 295                 300                 


Phe Pro Ser Ala Thr Tyr Ala Gln Asn Asn Gly Val Ile Gln Met Thr 
305                 310                 315                 320 


Gly Val Ala Ala Arg Arg Ile Gly Trp Ile Met Ala Val Ile Leu Leu 
                325                 330                 335     


Cys Leu Gly Leu Phe Pro Pro Val Gly Arg Trp Ile Thr Val Met Pro 
            340                 345                 350         


Ser Cys Val Leu Gly Ala Leu Ala Ile Met Leu Phe Gly Leu Val Ala 
        355                 360                 365             


Val Ser Gly Leu Arg Leu Met Val Ser Gly Gly Leu Ser Gln Arg Asp 
    370                 375                 380                 


Ala Leu Ile Ala Ala Ile Ser Leu Gly Val Gly Ile Gly Val Pro Ser 
385                 390                 395                 400 


Gln Glu Glu Trp Leu Lys Thr Leu Pro Thr Val Val Gln Thr Phe Leu 
                405                 410                 415     


Glu Ser Gly Val Ser Ala Gly Gly Leu Ala Ala Leu Leu Leu Asn Leu 
            420                 425                 430         


Leu Leu Pro Ala Glu Gly Arg Lys Lys Met Met Gly Lys Glu Pro Ala 
        435                 440                 445             


Glu Met Leu 
    450     


<210>  19
<211>  9930
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic contrsuct / Exemplary Saccharomyces shuttle vector

<400>  19
cggatcccgg gcgagtttat cattatcaat actgccattt caaagaatac gtaaataatt       60

aatagtagtg attttcctaa ctttatttag tcaaaaaatt ggccttttaa ttctgctgta      120

acccgtacat gcccaaaata gggggcgggt tacacagaat atataacatc ataggtgtct      180

gggtgaacag tttattcctg gcatccacta aatataatgg agcccgcttt ttaagctggc      240

atccagaaaa aaaaagaatc ccagcaccaa aatattgttt tcttcaccaa ccatcagttc      300

ataggtccat tctcttagcg caactacaca gaacaggggc acaaacaggc aaaaaacggg      360

cacaacctca atggagtgat gcaacctgct tggagtaaat gatgacacaa ggcaattgac      420

ctacgcatgt atctatctca ttttcttaca ccttctatta ccttctgctc tctctgattt      480

ggaaaaagct gaaaaaaaag gttgaaacca gttccctgaa attattcccc tatttgacta      540

ataagtatat aaagacggta ggtattgatt gtaattctgt aaatctattt cttaaacttc      600

ttaaattcta cttttatagt tagtcttttt tttagtttta aaacactaag aacttagttt      660

cgaagttaac atttaaatca aacaaaatgt caacaacgct ctcatcatcc acttacggca      720

aggacaacgt caagttcctc aaggtcaaga aagatccgca gaacccaaag aagcaggagg      780

ttatggaggc caccgtcacg tgtctgcttg aaggtgggtt cgacacctcg tacacggagg      840

ctgacaactc gtccatcgtg ccaacagaca ccgtgaagaa caccattctc gtgttggcaa      900

agaccacgga gatttggcca attgagagat ttgcagccaa gctggccacg cactttgttg      960

agaagtactc gcacgtctct ggcgtctccg tcaagattgt ccaggacaga tgggtcaagt     1020

acgccgttga cggcaagcca cacgaccact cttttatcca cgaaggtggt gagaagagaa     1080

tcactgacct gtactacaag agatccggtg attacaagct gtcatctgcc atcaaggact     1140

tgacggtgct gaagtccacc ggctcgatgt tctacggcta caacaagtgt gacttcacca     1200

ccttgcaacc aaccactgac agaatcttgt ccaccgacgt cgatgccacc tgggtttggg     1260

ataacaagaa gattggcact gtctacgaca tcgccaaggc tgcagacaag gggatctttg     1320

acaacgttta caaccaggct agagagatca ccttgaccac cttcgccctg gagaactctc     1380

catctgtgca ggccacgatg ttcaacatgg ctactcagat cttggaaaag gcatgctctg     1440

tctactcggt ttcatacgcc ttgccaaaca agcactactt cctcattgac ttgaaatgga     1500

aaggtttgga gaacgacaac gagttgttct acccatctcc acatccaaat ggtttgatca     1560

agtgtactgt tgtccgtaag gagaagacca agttgtaatc acatatgaaa gtatataccc     1620

gcttttgtac actatgtagc tataattcaa tcgtattatt gtagctccgc acgaccatgc     1680

cttagaaata tccgcagcgc gggatccgat atcctactta ttcccttcga gattatatct     1740

aggaacccat caggttggtg gaagattacc cgttctaaga cttttcagct tcctctattg     1800

atgttacacc tggacacccc ttttctggca tccagttttt aatcttcagt ggcatgtgag     1860

attctccgaa attaattaaa gcaatcacac aattctctcg gataccacct cggttgaaac     1920

tgacaggtgg tttgttacgc atgctaatgc aaaggagcct atataccttt ggctcggctg     1980

ctgtaacagg gaatataaag ggcagcataa tttaggagtt tagtgaactt gcaacattta     2040

ctattttccc ttcttacgta aatatttttc tttttaattc taaatcaatc tttttcaatt     2100

ttttgtttgt attcttttct tgcttaaatc tataactaca aaaaacacat acataaacta     2160

aaagtgttga caattaatca tcggcatagt atatcggcat agtataatac gacaaggtga     2220

ggaactaaac catgggtaag gaaaagactc acgtttcgag gccgcgatta aattccaaca     2280

tggatgctga tttatatggg tataaatggg ctcgcgataa tgtcgggcaa tcaggtgcga     2340

caatctatcg attgtatggg aagcccgatg cgccagagtt gtttctgaaa catggcaaag     2400

gtagcgttgc caatgatgtt acagatgaga tggtcagact aaactggctg acggaattta     2460

tgcctcttcc gaccatcaag cattttatcc gtactcctga tgatgcatgg ttactcacca     2520

ctgcgatccc cggcaaaaca gcattccagg tattagaaga atatcctgat tcaggtgaaa     2580

atattgttga tgcgctggca gtgttcctgc gccggttgca ttcgattcct gtttgtaatt     2640

gtccttttaa cagcgatcgc gtatttcgtc tcgctcaggc gcaatcacga atgaataacg     2700

gtttggttga tgcgagtgat tttgatgacg agcgtaatgg ctggcctgtt gaacaagtct     2760

ggaaagaaat gcataagctt ttgccattct caccggattc agtcgtcact catggtgatt     2820

tctcacttga taaccttatt tttgacgagg ggaaattaat aggttgtatt gatgttggac     2880

gagtcggaat cgcagaccga taccaggatc ttgccatcct atggaactgc ctcggtgagt     2940

tttctccttc attacagaaa cggctttttc aaaaatatgg tattgataat cctgatatga     3000

ataaattgca gtttcatttg atgctcgatg agtttttcta atcagtactg acaataaaaa     3060

gattcttgtt ttcaagaact tgtcatttgt atagtttttt tatattgtag ttgttctatt     3120

ttaatcaaat gttagcgtga tttatatttt ttttcgcctc gacatcatct gcccagatgc     3180

gaagttaagt gcgcagaaag taatatcatg cgtcaatcgt atgtgaatgc tggtcgctat     3240

actgctgtcg attcgatact aacgccgcca tccagtttaa acgagctcga attcatcgat     3300

gatatcagat ccactagtgg cctatgcggc cgcatcagtt ctggaccagc gagctgtgct     3360

gcgactcgtg gcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt atccgctcac     3420

aattccacac aacatacgag ccggaagcat aaagtgtaaa gcctggggtg cctaatgagt     3480

gagctaactc acattaattg cgttgcgctc actgcccgct ttccagtcgg gaaacctgtc     3540

gtgccagctg cattaatgaa tcggccaacg cgcggggaga ggcggtttgc gtattgggcg     3600

ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt     3660

atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa     3720

gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc     3780

gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag     3840

gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt     3900

gcgctctcct gttccgaccc tgtcgcttac cggatacctg tccgcctttc tcccttcggg     3960

aagcgtggcg ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg     4020

ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg     4080

taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac     4140

tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg     4200

gcctaactac ggctacacta gaagaacagt atttggtatc tgcgctctgc tgaagccagt     4260

taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg     4320

tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc     4380

tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt     4440

ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt     4500

taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag     4560

tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt     4620

cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg caatgatacc     4680

gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc     4740

cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg     4800

ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctac     4860

aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg gttcccaacg     4920

atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc     4980

tccgatcgtt gtcagaagta agttggccgc agtgttatca ctcatggtta tggcagcact     5040

gcataattct cttactgtca tgccatccgt aagatgcttt tctgtgactg gtgagtactc     5100

aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat     5160

acgggataat accgcgccac atagcagaac tttaaaagtg ctcatcattg gaaaacgttc     5220

ttcggggcga aaactctcaa ggatcttacc gctgttgaga tccagttcga tgtaacccac     5280

tcgtgcaccc aactgatctt cagcatcttt tactttcacc agcgtttctg ggtgagcaaa     5340

aacaggaagg caaaatgccg caaaaaaggg aataagggcg acacggaaat gttgaatact     5400

catactctac ctttttcaat attattgaag catttatcag ggttattgtc tcatgagcgg     5460

atacatattt gaatgtattt agaaaaataa acaaataggg gttccgcgca catttccccg     5520

aaaagtgcca cctgacgtct aagaaaccat tattatcatg acattaacct ataaaaatag     5580

gcgtatcacg aggccctttc gtctcgcgcg tttcggtgat gacggtgaaa acctctgaca     5640

catgcagctc ccggagacgg tcacagcttg tctgtaagcg gatgccggga gcagacaagc     5700

ccgtcagggc gcgtcagcgg gtgttggcgg gtgtcggggc tggcttaact atgcggcatc     5760

agagcagatt gtactgagag tgcaccaaat gcggtgtgaa ataccgcaca gatgcgtaag     5820

gagaaaatac cgcatcaggc gccattcgcc attcaggctg cgcaactgtt gggaagggcg     5880

atcggtgcgg gcctcatcgc tattacgcca gctggcgaaa gggggatgtg ctgcaaggcg     5940

attaagttgg gtaacgccag ggttttccca gtcacgacgt tgtaaaacga cggccagtgc     6000

aacgcgatga cgatggatag cgattcatcg ataacgaagc atctgtgctt cattttgtag     6060

aacaaaaatg caacgcgaga gcgctaattt ttcaaacaaa gaatctgagc tgcattttta     6120

cagaacagaa atgcaacgcg aaagcgctat tttaccaacg aagaatctgt gcttcatttt     6180

tgtaaaacaa aaatgcaacg cgagagcgct aatttttcaa acaaagaatc tgagctgcat     6240

ttttacagaa cagaaatgca acgcgagagc gctattttac caacaaagaa tctatacttc     6300

ttttttgttc tacaaaaatg catcccgaga gcgctatttt tctaacaaag catcttagat     6360

tacttttttt ctcctttgtg cgctctataa tgcagtctct tgataacttt ttgcactgta     6420

ggtccgttaa ggttagaaga aggctacttt ggtgtctatt ttctcttcca taaaaaaagc     6480

ctgactccac ttcccgcgtt tactgattac tagcgaagct gcgggtgcat tttttcaaga     6540

taaaggcatc cccgattata ttctataccg atgtggattg cgcatacttt gtgaacagaa     6600

agtgatagcg ttgatgattc ttcattggtc agaaaattat gaacggtttc ttctattttg     6660

tctctatata ctacgtatag gaaatgttta cattttcgta ttgttttcga ttcactctat     6720

gaatagttct tactacaatt tttttgtcta aagagtaata ctagagataa acataaaaaa     6780

tgtagaggtc gagtttagat gcaagttcaa ggagcgaaag gtggatgggt aggttatata     6840

gggatatagc acagagatat atagcaaaga gatacttttg agcaatgttt gtggaagcgg     6900

tattcgcaat attttagtag ctcgttacag tccggtgcgt ttttggtttt ttgaaagtgc     6960

gtcttcagag cgcttttggt tttcaaaagc gctctgaagt tcctatactt tctagagaat     7020

aggaacttcg gaataggaac ttcaaagcgt ttccgaaaac gagcgcttcc gaaaatgcaa     7080

cgcgagctgc gcacatacag ctcactgttc acgtcgcacc tatatctgcg tgttgcctgt     7140

atatatatat acatgagaag aacggcatag tgcgtgttta tgcttaaatg cgtacttata     7200

tgcgtctatt tatgtaggat gaaaggtagt ctagtacctc ctgtgatatt atcccattcc     7260

atgcggggta tcgtatgctt ccttcagcac taccctttag ctgttctata tgctgccact     7320

cctcaattgg attagtctca tccttcaatg ctatcatttc ctttgatatt ggatcataaa     7380

gcttataacc taggaagctt gggcccgaat tcattttcaa catcgtattt tccgaagcgt     7440

tgcataatga aaatgtgata ataaggcagt gagctacttt gtcacaacaa agtacgagaa     7500

cagatgaggt tccgtggtgt ttttggggca accgcactat ttggagcgct gtatatattt     7560

atatcctact acaaaaaatc ataaatgaca ctgaattgga cacatgctag cgtcaaatac     7620

cttgcctggt aaagttgtgt gctagtgtct cccgtcttct gtctaagcct gcttgctctg     7680

atactccgcc tcgccatccc gattatcatg agcagagacc ggcatagggg tgacggcacc     7740

gatctcttcg acttcagcag gcatgattgc gttcaagagc atagcaacaa atgccgtgac     7800

cgcaaacccc gtctcaagca cgagctcgat cgcattttca aacccctcca ggtctctatt     7860

ctcggtctga gggaatacat tcccaaacca agtgggcacc agcgtcgccc cgtatcccag     7920

ggccattgac gcggtgagga taaaccgatt tcgccttgtg aacggcgcct tggccacgat     7980

cgcctgtccg ctaataacga ccgaagcgaa gagaaacgtc ttcatcccgc ccatgacact     8040

gttgggtatg gcaacaatgg ctgcagcgaa tttagcaaag ataccggcta ctatcaatat     8100

cagacagcag cagtatccgg cccagcggtt tgcgcagcga gtgagggcaa tcacgccgtt     8160

gttctgcgca aaggtcgtca tgggggtcat tgtcgcaagg gcagcgacta ccgagttgat     8220

cccgtctgct aggacggcgc cctggatgcg cgactcgaat gtgccgccgc ggacttcgag     8280

acgcgagacg tcgcaggtgg cggttacatc accgatgcac tcgcaggcgc agatgatgaa     8340

aaccgcgatg atcgggagaa ccatcggacc atagacagag agagggaaag tcttgaccca     8400

gatgaatgag gcggcagggg cagcgtcaat atcggcgtgg ctgaagtagc cgcaggctgc     8460

agcgactata caaccgacga gcagcccgat gacaacagaa caggacttca taatcggggc     8520

tccaaatcgt tcgcagagga tgatcgatac aaagactaga aaacccaggc cgatgaactc     8580

tggactcccc cacgggagag ggcgcggtgc agttgcggac gggcacagca tcccgtcatc     8640

catacacgcc gagccgccag cccagtcttt gaacccagtt ccaatcagac ttatcccgat     8700

aagcattaca gtgggaccag tgacgatggg cgggaagatt ttctgtatca ctttgggagg     8760

cacgaaagcg aggaggatct ccaccaaagc acagcaggcc gaggtgccaa tcaaggcgcc     8820

gtacgcttcg gggcaaggga gtctgtttcc agcctcgtcg agttgacaga acccgttcga     8880

gtacatctgg ttgaaggcgc cgctggcgac ggagatgatg gagaacgaga cccccataac     8940

tgagaggacg ccactgccga tatagtacgg tgtcttgtag atatgaaatc gcgttatctg     9000

gaccatcgac agcagcccgc agacgataag cgaggtcgaa acgagatact gctggagatc     9060

ggacggcagg ctcagcgagc ttgatatgat cagaggagga gtgaccacac ccgccaacat     9120

ggcaagcgca tgctgaagac ccaggataaa cgccaacagc acgggaatct tctcgttgag     9180

gccaaaaaaa ggcggcgccc gtggatcttt cttcatgaag ggtagctcgg gccggaaaag     9240

gaagccatag tcatagtcgc cgatcaggcc ctcgcgggtc gtcagatgcc tagccagcaa     9300

gcggactctc tgtcggacgg tcttcttggg gttggagttg gggatgacgg agtcggggcc     9360

gtcggttgaa tggatggagt tgtccattgt tttatatttg ttgtaaaaag tagataatta     9420

cttccttgat gatctgtaaa aaagagaaaa agaaagcatc taagaacttg aaaaactaag     9480

aattagaaaa gaccaaatat gtatttcttg cattgaccaa tttatgcaag tttatatata     9540

tgtaaatgta agtttcacga ggttctacta aactaaacca cccccttggt tagaagaaaa     9600

gagtgtgtga gaacaggctg ttgttgtcac acgattcgga caattctgtt tgaaagagag     9660

agagtaacag tacgatcgaa cgaactttgc tctggagatc acagtgggca tcatagcatg     9720

tggtactaaa ccctttcccg ccattccaga accttcgatt gcttgttaca aaacctgtga     9780

gccgtcgcta ggaccttgtt gtgtgacgaa attggaagct gcaatcaata ggaagacagg     9840

aagtcgagcg tgtctgggtt ttttcagttt tgttcttttt gcaaacaaat cacgagcgac     9900

ggtaatttct ttctcgataa gaggcggtac                                      9930


<210>  20
<211>  1272
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct / Exemplary E. coli malE/K expression 
       cassette

<400>  20
gcggccgctt gcaagcaaca tcacgaaatt ccttacatga cctcggttta gttcacaggg       60

taccagttgt tcttattggt ggtgttgctt tatggttgca tcgtagtaaa tggttgtaac      120

aaaagcaatt tttccggctg tctgtataca aaaacgccgc aaagtttgag cgaagtcaat      180

aaactctcta cccattcagg gcaatatctc tcttggatcc aaagtgaact ctagaaataa      240

ttttgtttaa ctttaagaag gagatataca tatgactgcc accgcagaaa cctcaaccgg      300

caccaaggtc gtgctcggac agaaccagta cggcaaggcc gaagtccgcc tcgtcaaggt      360

cacgcgcaat accgcccggc acgagatcca ggacctgaat gtcacctcgc agctgcgcgg      420

cgacttcgag gccgcacaca ccgccggcga caacgcgcac gtggtcgcca ccgacacgca      480

gaagaacacc gtctacgcct tcgcccgcga cggcttcgcc accaccgagg agttcctgct      540

ccggctgggc aaacacttca ccgagggctt cgactgggta accggcgggc gctgggcggc      600

gcagcagttc ttctgggacc gcatcaacga ccacgaccac gccttctccc ggaacaagag      660

cgaggtccgc accgccgtgc tcgagatctc gggcagcgag caggccatcg tcgccgggat      720

cgagggcctg acggtcctga agtccaccgg ttcggaattc cacggcttcc cgcgggacaa      780

gtacaccacc ctgcaggaaa ccaccgaccg tatcctcgcc acggatgtca gcgcccgctg      840

gcgctacaac accgtcgagg ttgacttcga cgccgtctac gcgagcgtcc gcgggctgct      900

gctcaaggcc ttcgccgaga cccactcgct ggccctgcag cagaccatgt atgagatggg      960

ccgggccgtc atcgagacgc acccggaaat cgacgaaatc aagatgtccc tgccgaacaa     1020

gcaccatttc ctggtggacc tgcagccctt cggacaggac aacccgaatg aggtgttcta     1080

cgccgccgac cgtccctacg gactgatcga agccaccatc cagcgcgagg gctcgcgcgc     1140

cgaccacccg atctggtcga acatcgccgg attctgctag cgcaaaaaac cccgcttcgg     1200

cggggttttt tcgcaagccg cgttctcatc ctcccgcctc ctcccccata aaaaagccag     1260

gggggcggcc gc                                                         1272


<210>  21
<211>  1960
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct / Exemplary E. coli LacZ expression cassette

<400>  21
gcggccgcga cgccattgct gccaggcgct gatgtgtccg gcttctgacc atgcggtcgc       60

gtttggttgc actacgcgta ccgttagcca gagtcacatt tccccgaaaa gtgccacctg      120

catcgatggc cccggtacca gttgttctta ttggtggtgt tgctttatgg ttgcatcgta      180

gtaaatggtt gtaacaaaag caatttttcc ggctgtctgt atacaaaaac gccgtaaagt      240

ttgagcgaag tcaataaact ctctacccat tcagggcaat atctctcttg gatccaaagt      300

gaactctaga aataattttg tttaacttta agaaggagat atacatatgt gtttagacag      360

tttcattaac gtaaacggtt gctttttatt ctggcgggcg aaaggagaaa cactgatgag      420

cgccatagat tcccaacttc cctcatcttc tgggcaagac cgcccaactg atgaggttga      480

ccgcatatta tcaccaggaa agctgatcat actcggtctg caacacgtcc ttgtcatgta      540

cgcaggtgca gtcgctgttc ctcttatgat tggtgaccga ctgggcctct caaaagatgc      600

tattgcgatg ctcattagct cggatctctt ttgctgcggg atcgtcacat tattgcaatg      660

tatcggtatc ggccgcttta tggggatccg cctgccggtg attatgtcgg tgacctttgc      720

tgctgtaaca ccaatgatag ccattgggat gaacccggat atcggcctgc tggggatatt      780

tggtgccact atcgccgcgg gttttatcac cacattatta gcgccactta ttggtcgctt      840

gatgccttta ttcccgccac tggttaccgg tgtggttatt acttctattg ggcttagcat      900

cattcaggtg ggtattgact gggccgctgg aggtaaaggg aatccgcaat atggtaatcc      960

cgtttattta ggtatctcct ttgccgtctt aatttttatc ttgctcatta ctcgctatgc     1020

gaaaggattt atgtccaacg tcgccgtatt actggggatt gtatttggct ttttactttc     1080

gtggatgatg aatgaagtca atttatccgg gctacatgat gcctcgtggt ttgcgattgt     1140

caccccgatg tcgtttggta tgccgatttt cgatcccgtt tccattctga ccatgactgc     1200

cgtgttaatc atcgtgttta tcgagtcgat ggggatgttc ctggcactgg gtgaaatagt     1260

cggtcgtaaa ctctcttcac acgatattat ttgcgggctg cgtgtcgatg gcgtagggac     1320

aatgataggc ggcacgttta acagcttccc ccacacgtca ttttctcaaa acgttggcct     1380

ggttagcgtg atgcgcgttc atagccgctg ggtgtgtatt tcttcgggaa ttatattaat     1440

cctgtttggc atggtgccaa aaatggcggt gctggtagcc tccattccgc aatttgtgct     1500

gggcggcgct ggtctagtga tgttcggcat ggtactggcg acagggattc gaattctgtc     1560

gcgctgtaac tacaccacca accgttacaa cctctatatt gtggcgatca gtctcggcgt     1620

tggcatgact ccgacgctct ctcacgattt cttttctaag ttaccggccg tactgcaacc     1680

gctgctacat agcggcatta tgctcgcaac ccttagcgcc gttgtgctga acgtcttctt     1740

taatggctat cagcatcatg ctgacctggt gaaggaatcc gtctctgata aagatttaga     1800

agtcaggaca gtacgtatgt ggcttctgat gcgcaagctg aagaaaaatg agcatggaga     1860

ataaaaaaaa aaaccccgcc cctgacaggg cggggttttt tttttgccgt tttcatcata     1920

tttaatcagc gactgatcca cccagtccca gaccggccgc                           1960


<210>  22
<211>  11378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct / Exemplary Bacteroides transformation vector

<400>  22
ggagagctgt atgtggggtg gaagaagcta tcgtaaaaat gctggagcag cttgatcctc       60

attctaccta ttctgatccg gaggaagtga agagaatgaa cgagccgttg cagggaaact      120

tcgaaggtat cggtatacag tttaatatgg cggaggacac tttgctggtg atacagcctg      180

tatcgggcgg accgtccgaa aaagtcggta ttctggccgg tgatcgtatc gtcatggtgg      240

aagatacgct gatagccggt gtaaagatga gtaccgagga tattatgcgt cgcctccgtg      300

gtcctaaaga ttcaaaagtg aatctgaaaa tacttcgccg aggggtgaag gaactgctcc      360

cctttacggt gaaaagggat aaaaccgttt tgccgccact acccatgagg agttcaagaa      420

agcgctgacc gggttgcaga agaaaggaat gaaagacttg attcttgatt tgcagggcaa      480

tggcgggggg tatttgaatg ctgctatcga tattgccaat gaatttttgg gtaaaaagga      540

actgattgtc tatacggagg gccgtcgtaa tcctcgtagc gagttttttg ccaaaggtac      600

gggcgagttt cagaacggtc gtctgatggt attggttgat gaattttcgg cttctgccag      660

tgagattgtg accggagctg ttcaggattg ggacagaggc gttgtggtag gccgtcgcag      720

ttttggtaaa ggcttggtgc agcgtcccat tgatttgccg gacggttcga tgatccgtct      780

gacggtggcc cgctattata cgcctgccgg acgttgtatc cagaaacctt acgagagcat      840

tgaaaagtat aatgaagacc tgatagaccg ttataataaa ggagaaatga tgagtgaaga      900

cagcatccac tttccggatt cactgaagtt caagactcat aggttggccc gtacggtata      960

tggtggcgga gggatcatgc ccgattattt tgtgccgatt gatacgactc tctatactaa     1020

ataccatcgt cagttgcgtg ataaaggagc attgatgaaa gctcatttcc attttattga     1080

tgcccatcgt aaagaatggc tgggcaaata caagactttc aatgagttct acaaacgttt     1140

tgaagtgact ccggatatgt tgacacaact ggttgctacc ggcaaggaga tgggagtgga     1200

atataatgaa gaagagtatc aaaaggccct gcctctgctg aggttgcaga tgaaagcatt     1260

gatagcccgt gatttatggg atatgaatga atattatcac gtcattaatg acgcgaatga     1320

aagtatcagg aaagcgctgg aactgttgga gcaaccggac tttgaggggc tgctgttgaa     1380

aaagcgatag tcaagacttt atattaactg caggggcgca tagttgcact cctgcagttg     1440

tctgaaaaac ttgtaggata aaacgaaagg ctcagtcgaa agactgggcc tttcgtttta     1500

caattgggct accttttttt tgttttgttt gcaatggtta atctattgtt aaaatttaaa     1560

gtttcacttg aactttcaaa taatgttctt atatttgcag tgtcgaaaga aacaaagtag     1620

cctggcatct taatcaattt taaactcacc aaatcaaaat atgaaaaaaa aaaataataa     1680

aatgaagctc accttgaaaa aaaatgcgta cggaaagaat gccgtgaacc tgtcaaaaat     1740

cattcggcac cctaactacc atgaattcag acagatctcc gtcaacgtat cgctggaagg     1800

agactttgaa acggcccaca cgctcggcga caattcaaaa atagtaccta ccgatacgca     1860

gaaaaacacg gtgtatgcgc tggccaaaga gcattttgtg gattctatcg aaaatttcgg     1920

cctctattta gccaattatt ttatcaccaa taatccgcag gtatcgcagg ccaccgtcca     1980

tattatcgag catccctggg ctcgcatggc cttcgatgga gagccgcatc atcatgccta     2040

tgtgggtggc ggttctgaaa aacggacaac aaccttagta cagactaccg aagcaattcg     2100

tgtgacctcg ggcatcaaag atctgctgat tctaaaaaca accgattcgg gatttgaggg     2160

ctacgtcaaa gaccaataca caaccctgaa agaaacggcc gaccgcattt tcgcgaccca     2220

atgcgaggcc aactgggtgt acacttccca caaccttgac tttacgagtc tgttcggcaa     2280

aatccgcgaa acgctactaa aaaccttcgc gcatcacaag agtctgtcgg tgcagcaaac     2340

gttgctggct atgggatcgg ccgtcttgga agagaatcag gaagtaagcg aaataagcct     2400

gatcatgccc aacaaacatc acatcccgtt taacctggaa cagttcggca tggacaacca     2460

aaacgagatt ttcatagcca ccgacgagcc gtacgggtac attacgggaa cggtgacgag     2520

ggagtaaaaa ttataaataa attaataaac ttttattaaa aaaaaattac aaaatgagcg     2580

aacccgttaa cgcgcaatct acccgtctcg tttacggtct ggaagacaag gttcctttgg     2640

ttccggcgct tttagtgagt ttacaacagg ttggggctat ggtggtcggc accatcacac     2700

cagcgctgat attgtcgggt atccttcact ttgacccaca ggataccgct tatttagtaa     2760

gcatggcgtt ggtagcgtcg gcactgggta cgtttttgca aacgatgcgg ctcggtttca     2820

ttggctctgg cttactgagc atcacgggta ccagcttcgc ttttttggca ccgcttattc     2880

aggcgggtgt aacgggcggc ttgccgctta tggtcggtat gtcgctggca ggaacgccgg     2940

tacagctggc attagcccct tttctgccca aactaaaacg agtcttcaca cccttagttt     3000

cgggaattgt ggtgttgcta atcggccttt cattgattcc gacgggtatg cgaagtattg     3060

cccaattgcc ggccgaaggt gccccggcct ggagtggtgg tctggttgcc ctgattgtca     3120

ttgtggtcat gatcattgct caatcgattg gcaaagcctg ggctcgaatg gctgctgtac     3180

tcgttggcgt ggttacgggt tatacgattt gtggactcat gggttggctt caatctcctg     3240

ctccgagcaa tggttcctgg ctcacccttc cgcagctgtt tccatatggc ttggccttta     3300

aatgggaatt actgtttcca ttcgcgttta tatacctcgt ttgcgtgctg gaagcgatgg     3360

gcgatattac agccacctct caactgtcag gcttaccgac cgatggccct gaccattggg     3420

ctcgaattcg tgggggtatc ctagccgacg gactgacctg cattggatcg acgttgattg     3480

gtggctttcc gagtgctacc tacgcccaga acaacggggt gattcaaatg acaggagttg     3540

cggctcgccg aatcggctgg atcatggcgg ttattctact atgtctgggc ctctttccac     3600

cagttgggcg ctggattacc gtaatgccat cctgtgtact cggcgcgctg gctatcatgc     3660

tttttggctt agtggccgtt tcgggacttc gcctgatggt atctggcggg ttatcgcaac     3720

gggatgcgct gattgctgcg atttctttag gcgttggcat tggggttcca tcgcaggagg     3780

agtggttaaa aacgcttccc accgttgtgc agacgttcct ggaatcgggc gtttcggcag     3840

gtggattagc ggccttactg ctcaatctgt tactaccagc agaaggacga aagaagatga     3900

tgggaaaaga acctgccgaa atgttataga ataatgaata atgaataatg aataatgaat     3960

aatgaataat gaataatgaa taatgaataa tgaataatga ataatgaata atgaataatg     4020

aataatgaat aatgaataat gaataatgaa taatgaataa tgaataatgt accagacaat     4080

cgttcattgt tatctggatg acctatttat ttgctagtgc cgttagggtt cctagctgat     4140

tagaaggcca tcctgacgga tggccttttt tttgactctg ttgtgtcttc ttttaggtgt     4200

ggaataattt tccaaccatc actttatctg tctcccgaac agcaccttat tcagccatcg     4260

gttcacatac acgttcacga aagcacatcc tactccgata gcggctcctg ccactacatc     4320

actgggatag tgcacccctt ggttcatccg ggcaaaccct actccgcaag cccatacggc     4380

tgaaggggcg ataacatacc acttaggata agtgatggag agtgaggtgg ctaaagaaaa     4440

agctgccgca gtgtgtcctg aagggaatga cggactatcg gcatccggtg ctccgtatgc     4500

atgaatctta tccggatact ttacaaaagg ccggtcacga cctattatat gtttggcggc     4560

gtatgtaatc cccactgctt caatcacact ggttcctatg taaatggcat ctttcagcat     4620

cggctggtct ttctttatca atgcatagag tcccatggct gtaggtattc ctacgggtag     4680

aatcactccg ctagcggaca atccgcggct cagtccgtgt acatcccatc ggttgatggt     4740

tttcaacgtg ttgatgtcta tattctgtgc gctgaggctg aatgtaaaac aggctgtcag     4800

tataagaaaa ataatccttt ggcgtttcat ttagtttggc atttgttcag tgcaaagata     4860

ggaaaataat gtaattcgca tttacccttc cccgaattaa agaataattt ccataattcc     4920

ttgtattatc gctagaattc ctttactttt gcatcgtgaa tacacagctt ttaacagaat     4980

ttttagttct aacaattaaa taatttaaat tcaatcattt atgtggttaa gtaattcatc     5040

tattggaagg aaagtggtga tgagtgtcac aggtatcgcc cttgtcctgt ttctgacgtt     5100

tcacatggcg atgaaccttg ttgcgctctt ctcggaagat gcttacaaca tgatttgtga     5160

attcttggga gctaactggt acgcgttggt tgcaactgcc gggctggctg ctctgtttgt     5220

aattcacatc atctacgctt tctggttgac catgcagaac cgtgcagctc gcggtagcga     5280

acgttatgca gtgaacgtta aacctaaaac tgtggaatgg gcatctcaga acatgcttgt     5340

cctgggtatt gtcgttattg ccggattggc tcttcatttt gccaatttct ggtacaaaat     5400

gcagtttgcc gaaattatcg gtgttcatga tttgggcgca ttcggtccta cagacggtgc     5460

cgcttacatt cgtgaaacat tcggatgccc tgtatttaca gtgctttacc tcatttggtt     5520

agcagctttg tggttccacc tgactcacgg attctggagt gctttgcaga ctttgggctg     5580

gagcaataaa atctggttcg agcgttggaa gactattggt aacatctact ctactttggt     5640

agttcttggt tttgcagcag tagtcgttat ctacttcgct atgactggcg cgcctgatag     5700

gtgggctgcc cttcctggtt ggcttggttt catcagccat ccgcttgccc tcatctgtta     5760

cgccggcggt agccggccag cctcgcagag caggattccc gttgagcacc gccaggtgcg     5820

aataagggac agtgaagaag gaacacccgc tcgcgggtgg gcctacttca cctatcctgc     5880

ccggctgacg ccgttggata caccaaggaa agtctacacg aaccctttgg caaaatcctg     5940

tatatcgtgc gaaaaaggat ggatataccg aaaaaatcgc tataatgacc ccgaagcagg     6000

gttatgcagc ggaaaagcgg gattaaaagt cggggattgg tgaacaaaaa ggtgtttctc     6060

tctttaagag aaatatcgtt ttgctaaaca gttgatattg aggtatcatt ttatcgtaaa     6120

agacattttt gctcaacaat tgcttgacgg aaatcaacaa attttagcat tttgtaaaaa     6180

agtcgctata taatttggtg aattggagtt attttcatat ttttgcatcc cgaagagttt     6240

ctcttaaaga gagaaacatc ttttgcatac cttttccgac cgaattttta tgtcgtaaag     6300

aggggctttg cagggggtgg actcagaaag atgagaatag atgactattg tagttgaaac     6360

acatagaaag ttgctgatat acagaccgat acgcatatcg ggatgaacca tgagtacgtt     6420

cttttctcaa aaaacataaa tattcgaaaa gagatgcaat aaattaagga gaggttataa     6480

tgaacaaagt aaatataaaa gatagtcaaa attttattac ttcaaaatat cacatagaaa     6540

aaataatgaa ttgcataagt ttagatgaaa aagataacat ctttgaaata ggtgcaggga     6600

aaggtcattt tactgctgga ttggtaaaga gatgtaattt tgtaacggcg atagaaattg     6660

attctaaatt atgtgaggta actcgtaata agctcttaaa ttatcctaac tatcaaatag     6720

taaatgatga tatactgaaa tttacatttc ctagccacaa tccatataaa atatttggca     6780

gcatacctta caacataagc acaaatataa ttcgaaaaat tgtttttgaa agttcagcca     6840

caataagtta tttaatagtg gaatatggtt ttgctaaaat gttattagat acaaacagat     6900

cactagcatt gctgttaatg gcagaggtag atatttctat attagcaaaa attcctaggt     6960

attatttcca tccaaaacct aaagtggata gcacattaat tgtattaaaa agaaagccag     7020

caaaaatggc atttaaagag agaaaaaaat atgaaacttt tgtaatgaaa tgggttaaca     7080

aagagtacga aaaactgttt acaaaaaatc aatttaataa agctttaaaa catgcgagaa     7140

tatatgatat aaacaatatt agtttcgaac aatttgtatc gctatttaat agttataaaa     7200

tatttaacgg ctaaaaacaa taggccacat gcaactgtaa atgtttacgc gggtaccgac     7260

accgcggtgg aggggaattg tgttacaacc aattaaccaa ttctgattag aaaaactcat     7320

cgagcatcaa atgaaactgc aatttattca tatcaggatt atcaatacca tatttttgaa     7380

aaagccgttt ctgtaatgaa ggagaaaact caccgaggca gttccatagg atggcaagat     7440

cctggtatcg gtctgcgatt ccgactcgtc caacatcaat acaacctatt aatttcccct     7500

cgtcaaaaat aaggttatca agtgagaaat caccatgagt gacgactgaa tccggtgaga     7560

atggcaaaag cttatgcatt tctttccaga cttgttcaac aggccagcca ttacgctcgt     7620

catcaaaatc actcgcatca accaaaccgt tattcattcg tgattgcgcc tgagcgaggc     7680

gaaatacgcg atcgctgtta aaaggacaat tacaaacagg aatcgaatgc aaccggcgca     7740

ggaacactgc cagcgcatca acaatatttt cacctgaatc aggatattct tctaatacct     7800

ggaatgctgt tttcccgggg atcgcagtgg tgagtaacca tgcatcatca ggagtacgga     7860

taaaatgctt gatggtcgga agaggcataa attccgtcag ccagtttagt ctgaccatct     7920

catctgtaac atcattggca acgctacctt tgccatgttt cagaaacaac tctggcgcat     7980

cgggcttccc atacaatcga tagattgtcg cacctgattg cccgacatta tcgcgagccc     8040

atttataccc atataaatca gcatccatgt tggaatttaa tcgcggcctg gagcaagacg     8100

tttcccgttg aatatggctc ataacacccc ttgtattact gtttatgtaa gcagacagtt     8160

ttattgttca tgatgatata tttttatctt gtgcaatgta acatcagaga ttttgagaca     8220

caacgtggct ttgttgaata aatcgaactt ttgctgagtt gaaggatcag agcctacgtt     8280

ccgaatacgg tcaaaaaaaa ggccatccgt caggatggcc ttcgcattaa tatgccgctt     8340

cgaattcttt taggaagcgt gtatcgtttt cagagaacat acggaggtct ttcacctgat     8400

atttcaggtt tgtgatacgc tcgataccca taccgagtcc ataaccgctg tatattttgc     8460

tgtctatacc atttgattca agtacgttcg ggtctaccat accgcaaccg aggatttcta     8520

cccagccggt gtgtttacag aacggacatc ctttaccgcc gcagatatta cagctgatat     8580

ccatttccgc acttggttca gcaaacggga agtaagacgg acgcagacgg atctttgtat     8640

cagcaccgaa catttctttg gcaaagagca gcaatacctg cttcaagtcg gtgaatgata     8700

cgtttttatc tacatacagc gcttctacct gatggaagaa acagtgtgcg cgatagctga     8760

tagcttcgtt acgatataca cgtcccggac agatgatgcg gataggaggc tgtgaagttt     8820

ccatcacacg agtctgtaca gaagaagtat gtgtacgcaa tactacgtcc gggtgagctt     8880

cgataaagaa agtgtcctgc atatcgcgtg ccggatgatc ttcggcaaag ttcagtgccg     8940

agaacacgtg ccagtcatct tcaatttccg gaccttcggc aatgctgaat cccagacggg     9000

caaagatatc aatgatttcg ttctttacaa tggtgagcgg gtggcgtgta ccgagttcta     9060

caggataagc cgaacgcgtc aaatccagtc cgtcacaatc gttgtcctga ctttcaaaca     9120

tttctttcag cgcgttgatt ttgtcctgcg cttttgtttt cagttcattc agtctcatgc     9180

cgacttcttt tttctgttcg gcagctacat tacggaaatc tgccattaag tcgttaatgg     9240

ctcccttctt acttaggtat ttgatgcgga gagcttcgag ttcttcggca ttggaggcgt     9300

gtaaggcttc cacctctttc agaagttgtt caatcttagc tatcattttt taatattttt     9360

agcggccccg ttaaacaaaa ttatttgtag aggctgtttc gtcctcacgg actcatcaga     9420

ccggaaagca catccggtga cagctcaggc tactttgttt ctttcgacac tgcaaatata     9480

agaacattat ttgaaagttc aagtgaaact ttaaatttta acaatagatt aaccattgca     9540

aacaaaacaa aaaaaaggta gcccaattgt aaaacgaaag gcccagtctt tcgactgagc     9600

ctttcgtttt atcctacagt cgctcggcga tcgaaggctt cggaaaaaaa aggccatccg     9660

tcaggatggc cttcgcatta atatgccgct tcgaattctt ttaggaagcg tgtatcgttt     9720

tcagagaaca tacggaggtc tttcacctga tatttcaggt ttgtgatacg ctcgataccc     9780

ataccgagtc cataaccgct gtatattttg ctgtctatac catttgattc aagtacgttc     9840

gggtctacca taccgcaacc gaggatttct acccagccgg tgtgtttaca gaacggacat     9900

cctttaccgc cgcagatatt acagctgata tccatttccg cacttggttc agcaaacggg     9960

aagtaagacg gacgcagacg gatctttgta tcagcaccga acatttcttt ggcaaagagc    10020

agcaatacct gcttcaagtc ggtgaatgat acgtttttat ctacatacag cgcttctacc    10080

tgatggaaga aacagtgtgc gcgatagctg atagcttcgt tacgatatac acgtcccgga    10140

cagatgatgc ggataggagg ctgtgaagtt tccatcacac gagtctgtac agaagaagta    10200

tgtgtacgca atactacgtc cgggtgagct tcgataaaga aagtgtcctg catatcgcgt    10260

gccggatgat cttcggcaaa gttcagtgcc gagaacacgt gccagtcatc ttcaatttcc    10320

ggaccttcgg caatgctgaa tcccagacgg gcaaagatat caatgatttc gttctttaca    10380

atggtgagcg ggtggcgtgt accgagttct acaggataag ccgaacgcgt caaatccagt    10440

ccgtcacaat cgttgtcctg actttcaaac atttctttca gcgcgttgat tttgtcctgc    10500

gcttttgttt tcagttcatt cagtctcatg ccgacttctt ttttctgttc ggcagctaca    10560

ttacggaaat ctgccattaa gtcgttaatg gctcccttct tacttaggta tttgatgcgg    10620

agagcttcga gttcttcggc attggaggcg tgtaaggctt ccacctcttt cagaagttgt    10680

tcaatcttag ctatcatttt ttaatatttt tagcggcccc gttaaacaaa attatttgta    10740

gaggctgttt cgtcctcacg gactcatcag accggaaagc acatccggtg acagctcagg    10800

ctactttgtt tctttcgaca ctgcaaatat aagaacatta tttgaaagtt caagtgaaac    10860

tttaaatttt aacaatagat taaccattgc aaacaaaaca aaaaaaaggt agcccaattg    10920

taaaacgaaa ggcccagtct ttcgactgag cctttcgttt tatcctagga tcagctgtac    10980

gtactcgcag ttcaacctgt tgatagtacg tactaagctc tcatgtttca cgtactaagc    11040

tctcatgttt aacgtactaa gctctcatgt ttaacgaact aaaccctcat ggctaacgta    11100

ctaagctctc atggctaacg tactaagctc tcatgtttca cgtactaagc tctcatgttt    11160

gaacaataaa attaatataa atcagcaact taaatagcct ctaaggtttt aagttttata    11220

agaaaaaaaa gaatatataa ggcttttaaa gcttttaagg tttaacggtt gtggacaaca    11280

agccagggat gtaacgcact gagaagccct tagagcctct caaagcaatt ttgagtgaca    11340

caggaacact taacggctga catggggcgg ccgcgtag                            11378


<210>  23
<211>  6047
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct / Exemplary Bacillus transformation vector

<400>  23
ggatccacaa tgatcattca tacgaagtac catggccaaa tgaacataaa agaagaacaa       60

atcattcttt ttgaaagcgg gattccaggc tttttagaag aaaaacagtt cgtcatactt      120

ccgctttcag aagactctcc attcgtggca ctgcagtccg tcacttcaga aaatcttgcg      180

tttatcgtcg taagtccgtt tatctttttt aagaattatg aatttgatct tgatgaatca      240

actgctgaac ttttggatat cgataatatt caagacgtag aagtcatgac aatattgact      300

atggcagagc catttgaaaa gtctactgcg aatttattgg ctcccattat tgtgaatcgc      360

aagaacatga tggctaagca agtcgtttta cacgactcct catatacgac aaagcatccg      420

attggaggag aatcatgcta gttttatcgc ggaaaataaa cgaagcgatt caaataggtg      480

ctgatattga agtaaaagtg attgcggttg aaggggatca agtgaagctt ggaattgacg      540

ccccaaagca tattgatatt cacaggaaag aaatttactt gaccattcag gaagaaaata      600

accgtgcagc agcgttatcc agcgatgtga tctccgcatt atcctcacaa aaaaagtgag      660

gattttttta tttttgtatt aacaaaatca gagacaatcc gatattaatg atgtagccgg      720

gaggaggcgc aaaagactca gccagttaca aaataagggc acaagaacgt gccttaacaa      780

catattcagg gaggaacaaa acaatgatgt atgcaggtgc gattttggtg cccctgcttg      840

tcggcagggc gctgaatgta acaactgaac agctgtccta cctattggcg attgacctgt      900

taacatgcgg cgtcgctacg cttttgcaaa ccttgcgcgg aacatacatc ggcatcgggc      960

ttcccgtcat gcttggcagt tcatttgtgg ccgtcacccc aatgattgca atcggcagca     1020

attacggcat tcacgcgatt tatggttcca tcattgcggc cggtgtgttc atctttttgt     1080

ttgcgcgttt tttcggcaag ctgactgtgt tatttcctcc tgtcgtaaca ggtaccgttg     1140

tgaccttgat cggcctttca cttgttccga caggtgtgaa aaatatggct ggcggcgaaa     1200

aaataaacgg cagcgccaac cccgaatacg gttcgctcga aaaccttctt ctctctgtcg     1260

gtgtccttgt tctgatctta gtcctcaacc gctttctcaa aggatttgcc cgaacactgt     1320

ccgttctgat cggcatcgcc gccggaacag cggcagcagc gatcatgggc aaagtcagct     1380

tttcttctgt tacagaagca ccgttcttcc aaatcccgaa gcctttttac ttcggagccc     1440

ctgcgtttga aatcggtccg atcttaacga tgctgatcgt cggaatcgtc attattgtgg     1500

aatcaaccgg cgttttttac gcaatcggaa agatatgcgg cagaccttta actgacaaag     1560

atctcgtcaa aggctatcga gcggaaggaa tcgccattct catcggcggg ctgttcaatg     1620

cctttcctta taataccttt gcgcaaaacg ccggcttatt gcagctgacc aaagtgaaaa     1680

caagaaacat cgtcgttacc gcaggctgta tccttgtctg tctcggactg attccgaaga     1740

ttgccgccct tgcatctgcc gttcctgctg ctgtacttgg cggcgcgacc gtcgtcatgt     1800

tcggcatggt gattgcctcc ggcgtcaaaa tgctcagcac agcggatctc aaaaatcaat     1860

accacctcct gaccatcgca tgctcaatcg cactcggcat cggcgccagc acggcccccg     1920

ggatttttgc tgaattcccc gctccgatcc ggattctggt cagtgacggc accatcaccg     1980

gaagcctaac cgccatcttt ttgaatctat ttttcagctt gcgcgacaaa aaagaattaa     2040

cagcacagca aacagaactt ccggtattag aacatacact cgcattagaa aaagaggtgt     2100

aaaaaagatg aaggaacagc acaatgcctt acagctaatg atgctggggc ttcagcacat     2160

gcttgccatg tatgcgggag ccattctcgt tccgttgatc gtcggagcag cgatcgggct     2220

gaatgcgggg cagctgacgt atttaatcgc gattgatttg tttatgtgcg gggcggcaac     2280

tcttttgcag ctctggagaa accgatattt cggcatcggc cttcccgttg tgctcggatg     2340

cacgtttacc gcagtcggcc cgatgatttc catcggaagc acttacggtg tcccagcgat     2400

atatggtgcc attatcgccg caggactgat tgtcgtctta gccgcgggct tcttcgggaa     2460

gcttgtccgt ttttttccgc ctgtcgtaac cggatcagtc gtcatgatca tcggcatcag     2520

cctgattcca acggcaatga ataacctggc cggaggtgaa ggaagcaaag aattcggctc     2580

actcgacaac gtgctcctcg ggtttggcgt cacagctttt atcttattgc tgttttattt     2640

ctttaaaggc tttatccgct ccatagcgat tttactcggt cttatcgcag gaacagcggc     2700

tgcatatttc atgggaaagg tcgatttttc tgaggttttg gaggcgtctt ggcttcatgt     2760

tccgtctctg ttttatttcg gaccgccaac ctttgagctg ccggctgttg tcacgatgct     2820

tctcgttgca attgtcagcc tcgttgaatc gacaggcgtt tattttgccc tcgctgatat     2880

cacaaaccgc aggctgtcgg agaaggatct ggaaaaaggc taccgggcag aaggccttgc     2940

gattttgctg ggcggcttat ttaacgcgtt tccctataca gctttctcgc agaatgtcgg     3000

catcgttcag ctctcaaaga tgaaaagtgt caacgtcatc gccatcacag gaatcatact     3060

ggtcgcgatc gggctggttc caaaagcagc ggccctgaca acagtgatcc ccaccccagt     3120

tctcggcggc gcaatgatcg tcatgttcgg catggtcatt tcttacggga tcaaaatgct     3180

atccagcgtt gaccttgatt cgcaaggcaa cctgctgatt atcgcctctt ccgtcagctt     3240

ggggcttggc gctacaacag ttcccgcgtt gttttcatct ctttcgggcg cggcctctgt     3300

cttggcagga agcggaattg tgatcggcag tttgacggcc attgcactgc acgctttttt     3360

tcaaaccaaa cagccgaata gcgcagacat aaaaacgtaa aggaagatgc caatgttcac     3420

aatggatgac ctgaaccaaa tggacacaca aacactgaca gacacacttg gctctatttt     3480

tgaacactct tcatggattg cggagagatc cgcagcacta cggccgtttt cgtccctttc     3540

tgatcttcac cgcaaaatga ctggcattgt aaaagctgcg gatcgcgaga cacagcttga     3600

tttaatcaaa aagcatcccc ggctcggaac aaagaaaaca atgagcgatg actcggtacg     3660

agagcagcag aacgcagggc tcggcaaatt agaacagcag gaatacgagg agtttctcat     3720

gctgaatgaa cactattatg atcgcttcgg ctttcctttt attttagcgg tgaagggaaa     3780

gacgaaacag gacattcacc aagccctgct ggcaaggctt gagagcgaac gagaaacgga     3840

gttccagcag gcccttatag aaatttaccg aatcgcccgc tttcgtctgg ctgacatcat     3900

cactgaaaaa ggagagacgc aaatgaaaag aaccatgtct tatggcaaag gaaatgtatt     3960

tgcataccga acgtatttaa aaccgctcac tggagtgaag caaatcccgg aatcatcttt     4020

tgccggaaga gataataccg ttgtcggcgt tgatgtgaca tgcgaaattg gcggagaagc     4080

cttcctgcca tcatttacag acggagacaa cactctcgtc gtggcaacgg attcaatgaa     4140

aaactttatc cagcgccatc tcgcatccta tgaaggaacg acaaccgagg ggttcctaca     4200

ctatgtagct caccgatttt tagataccta ttctcatatg gacacgatca ctctgactgg     4260

cgaagacatt ccgtttgaag caatgcctgc atacgaggag aaagagctca gcacaagccg     4320

cctcgtcttc agaagatcgc gtaatgaacg aagccgctct gtgctgaaag cagaacgaag     4380

cgggaatacc ataacgatta cagagcaata cagcgaaatc atggatcttc agctcgtcaa     4440

ggtgagcggc aactccttcg tcggcttcat ccgggacgaa tatacgactc tcccggaaga     4500

cggcaaccgc ccgctgtttg tctatttaaa catcagctgg caatatgaaa atacaaatga     4560

ctcatacgct tctgatccag cacgctacgt tgcggctgaa caagtccgcg acttagcgag     4620

caccgttttt cacgagctcg aaaccccttc aatccaaaac ctaatctatc atatcggctg     4680

cagaatatta gcgaggttcc cgcagctcac tgatgtcagc ttccaatctc aaaatcacac     4740

gtgggatacg gttgtcgaag aaatcccggg ctcaaaagga aaagtctaca ccgaaccgcg     4800

cccgccatac ggtttccaac attttaccgt gacaagagaa gacgccgaga aagaaaaaca     4860

gaaagccgct gaaaaatgtc ggagcctgaa agcctgatgg gaaaactgac aacccatatt     4920

ttagatttaa cctgcggcaa accagcggcg aacgtaaaaa ttggattgaa gcggctgggc     4980

gaaagtatta tgaaagaggt atacactaac aatgacggca gggtcgatgt ccctctgctg     5040

gctggtgaag agctgatgtc aggagagtat gtgatggaat ttcatgcagg agactatttt     5100

gcgagtaaaa acatgaacgc agccgatcag ccgtttttaa ccatcgtcac cgtccgtttt     5160

cagctagcag atccagatgc acattatcat atcccgctct tgctgtcgcc gtttggttat     5220

caggtgtata gggggagtta ataattttaa aaaagacctt ggcgttgcca gggtctttta     5280

atttaaattt ctatctccta atcattcctc atcctgtcac taactcatga tataataacc     5340

ggattctcca ctaacttttt ataaatgtat ttccatacaa gaaatctaaa acagaagatt     5400

tttttccaaa aatatgtgta atcttatctc gacttagtcg atataaacga tagattgggg     5460

cataggggat gatcaattga acattgaaag gctcactacg ttacaacctg tttgggatcg     5520

ttatgatact caaatacata atcagaaaga taatgataac gaggttcctg ttcatcaagt     5580

ttcatatacc aatcttgctg aaatggtggg ggaaatgaac aagcttttgg aaccttcgca     5640

agttcatctg aagttcgagc ttcatgacaa gttaaatgaa tactatgtaa aggtaataga     5700

ggactctaca aatgaagtga tccgcgaaat tccaccaaaa cggtggcttg atttttatgc     5760

ggctatgact gaatttcttg ggttatttgt agatgaaaaa aagtagaata ggagtggttt     5820

gagatggtca caagaataac aggtctggcg tcaggaatgg atatagatga tatcgtatca     5880

aagctgatgc agacagaaag agcgccgctt gataagctga cacaaaaaaa gcagactctt     5940

gaatggcagc gtgacagcta tcgtgaagta aactcaaaaa taaaagaatt gcaagattat     6000

atgtctaaaa atacgttgac atatccgagc acgtatcaga gggatcc                   6047


<210>  24
<211>  8128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct / Exemplary Kluyveromyces transformation 
       vector

<400>  24
ggcgcgccga aagtgattga agaaccctca aacttgctgg atatttcctt acccttgacc       60

tttaggcttt caattttacc caacaatttg tccaagacaa attgcaatcc actggattca      120

actgagacat aacgtttacc gtcgttgatc ttggtaggtt tttctgctgt ctctgtaaca      180

aaatctggta cctttaatgg aagttcggct tggccccagg caatttcatg acctgccttt      240

agaacaccag catcatcctt taacacggca acaacataag tggtatcaga aggaatagta      300

acagattctt ctggctttaa agctggaacg tcgattgtct ttcccgtgtc cttgtcgata      360

aacaataagt gatctgtcgt aatgaagtcg tgcttatttg tgattgttac agatccgtgc      420

gcaattttaa tatgaacggg ttcaataacc ttcttatact ctacaaggcc cggagtagga      480

ttatgctcac tgttacacaa accatccatg atgaacactc cgtcatgaac ctcttcctta      540

aagtcaccac cataagcata agctttatgc aacttaccat ctgcagtact aacatcttcg      600

aattcaatac cgtgatttgc ccattcccag ataaagccac cttggtaaaa cttctccttg      660

tagaacaact cttgatattc tttcaaagaa cccgggccgt tacccattgc atgaccgtac      720

tcacacaaga tcaaaggctt ttcaaactta ccattttcat cagtgtggtt cttcctccac      780

ctttccataa tttcaaatgt tgggtacatg aaactaaaga tatctgcact caaagcgttc      840

aagtcaccct cataatgcac cagtctggta ggatccaatt gcttaagcca gtcacgtgtg      900

aaacacgtga ctatacttac cctcacatta ccctcactct ttcacattac cctccccacc      960

atatcttccc cccccagctt cctgtcttcc actatccctg caaccaccac caccacacaa     1020

caaacagccc caaacaaccc ccaacagccc ggaaaaatcc acgcctcctc ccgaacacac     1080

gaagcccgcc ccggcttcca ctccaacact gccaacactg gaaccccgca ccacgtaacc     1140

acccacttta gtggctgccc gcccctcctg cgcttccctt gcgcttccct tgggaccaca     1200

ctccggtggc atggccctcg cttgctacat gctacctttt ttttgccctt ttctggcctt     1260

ttctggcttt tctggcctca ccacagtgta gtggtgtacc acagtgtaat ggtgtaacat     1320

tgtcgaatgg tattgtagcc tgttgtagcc tgttgtagcc tgttgtagcc tggtgtaatg     1380

tctggcatag tctggtgtct ggtgtctggt gtcttttgga aactgaacag tggaaagtgg     1440

aagtgaaaaa ttgtataaat ataggtgtcc cattcgtggt ttggtggatg tgtccttgac     1500

attgcaggtt tctctctgtt tcattgtgtt aagacttgtt aagacttgat aagtatttcc     1560

ctagtaatac cccaccaacc atcggttgat acattttaat acacactacc tatataaaga     1620

tacaaaatgg acaactccat ccattcaacc gacggccccg actccgtcat ccccaactcc     1680

aaccccaaga agaccgtccg acagagagtc cgcttgctgg ctaggcatct gacgacccgc     1740

gagggcctga tcggcgacta tgactatggc ttccttttcc ggcccgagct acccttcatg     1800

aagaaagatc cacgggcgcc gccttttttt ggcctcaacg agaagattcc cgtgctgttg     1860

gcgtttatcc tgggtcttca gcatgcgctt gccatgttgg cgggtgtggt cactcctcct     1920

ctgatcatat caagctcgct gagcctgccg tccgatctcc agcagtatct cgtttcgacc     1980

tcgcttatcg tctgcgggct gctgtcgatg gtccagataa cgcgatttca tatctacaag     2040

acaccgtact atatcggcag tggcgtcctc tcagttatgg gggtctcgtt ctccatcatc     2100

tccgtcgcca gcggcgcctt caaccagatg tactcgaacg ggttctgtca actcgacgag     2160

gctggaaaca gactcccttg ccccgaagcg tacggcgcct tgattggcac ctcggcctgc     2220

tgtgctttgg tggagatcct cctcgctttc gtgcctccca aagtgataca gaaaatcttc     2280

ccgcccatcg tcactggtcc cactgtaatg cttatcggga taagtctgat tggaactggg     2340

ttcaaagact gggctggcgg ctcggcgtgt atggatgacg ggatgctgtg cccgtccgca     2400

actgcaccgc gccctctccc gtgggggagt ccagagttca tcggcctggg ttttctagtc     2460

tttgtatcga tcatcctctg cgaacgattt ggagccccga ttatgaagtc ctgttctgtt     2520

gtcatcgggc tgctcgtcgg ttgtatagtc gctgcagcct gcggctactt cagccacgcc     2580

gatattgacg ctgcccctgc cgcctcattc atctgggtca agactttccc tctctctgtc     2640

tatggtccga tggttctccc gatcatcgcg gttttcatca tctgcgcctg cgagtgcatc     2700

ggtgatgtaa ccgccacctg cgacgtctcg cgtctcgaag tccgcggcgg cacattcgag     2760

tcgcgcatcc agggcgccgt cctagcagac gggatcaact cggtagtcgc tgcccttgcg     2820

acaatgaccc ccatgacgac ctttgcgcag aacaacggcg tgattgccct cactcgctgc     2880

gcaaaccgct gggccggata ctgctgctgt ctgatattga tagtagccgg tatctttgct     2940

aaattcgctg cagccattgt tgccataccc aacagtgtca tgggcgggat gaagacgttt     3000

ctcttcgctt cggtcgttat tagcggacag gcgatcgtgg ccaaggcgcc gttcacaagg     3060

cgaaatcggt ttatcctcac cgcgtcaatg gccctgggat acggggcgac gctggtgccc     3120

acttggtttg ggaatgtatt ccctcagacc gagaatagag acctggaggg gtttgaaaat     3180

gcgatcgagc tcgtgcttga gacggggttt gcggtcacgg catttgttgc tatgctcttg     3240

aacgcaatca tgcctgctga agtcgaagag atcggtgccg tcacccctat gccggtctct     3300

gctcatgata atcgggatgg cgaggcggag tatcagagca agcaggctta gtctgatctg     3360

cttactttac taacgacaaa aaaaatcaaa aaaaaaaaaa aaacaatcag tccttctctt     3420

cttacgatat gatatgatta aatgatgcta tgaaatcatc ttcttcttaa ctttcttaaa     3480

tcttacacgt cacttactct atatacccgt ttagctttgc ctggtcacag cgacatttta     3540

tataagtgta cgtattttct tttttttttt aaaaaatttc tattctaacc ttagaaaggt     3600

gtccagcgaa tatacagcgt gaataatgga atggccttgt attcgttttt tccgagagaa     3660

aaaaacgggc ttcggtgaaa atcgggtgaa tatgcaacta gcgggacgaa tgctctggaa     3720

atgcatatcc tatgcaacta gcgggatgaa caaatctcac cccagaattc gcaggaaaaa     3780

acaggaaaaa aaaaaagaag gccaccacgg ccacaaagac cacaaagacc acaaaaaaaa     3840

acaaaaaaca accgtcccag cttccagtgt ttggaatact ggaacacagg aagccgcata     3900

agagtgggcg ttgcacagga agccaggccc agaagcccca gagttacttt tttttttttg     3960

ttttttcctt ctgttcgctg tgcccgcatc agatgatgcg cctttattta cgatgccaat     4020

gcgaatagca ccagtgagag caccagtaaa agcatacgca tacacataca cacatagagc     4080

aagcaagcag gctagcaacc aggaaaggct gccagtgact gctactgggt gtctaagaac     4140

cgtagggcgg attattgttg cggtggttgg ttgcgggtgg ttatgcgatg gtacggtgca     4200

gaatcgtacg gtgttggtta tggaattagt atgggtatgt gatatgtggt aatatgtgat     4260

attgggttat tgtgatttgg aatactgaat atcgaatatg ggatatggaa tatggccatg     4320

gcatggtatg gtatgggatg ggagtattct attttatttt attttattct ggttcctgcg     4380

tttagggtag ggtaggaaga aggtgagtgc ttttgtatat aagtggagtg tctggatcag     4440

ttttgtggat tgtgaatgtt agtttcccct ttaatgtata tttgtattat ttgcttttga     4500

gtactcaata accaagcaca actactagtt ttaaaggatc catcctctta aacagtacaa     4560

atcgcaaaga aaagctccac acccaaacca aataattgca tgtcaacaac gctctcatca     4620

tccacttacg gcaaggacaa cgtcaagttc ctcaaggtca agaaagatcc gcagaaccca     4680

aagaagcagg aggttatgga ggccaccgtc acgtgtctgc ttgaaggtgg gttcgacacc     4740

tcgtacacgg aggctgacaa ctcgtccatc gtgccaacag acaccgtgaa gaacaccatt     4800

ctcgtgttgg caaagaccac ggagatttgg ccaattgaga gatttgcagc caagctggcc     4860

acgcactttg ttgagaagta ctcgcacgtc tctggcgtct ccgtcaagat tgtccaggac     4920

agatgggtca agtacgccgt tgacggcaag ccacacgacc actcttttat ccacgaaggt     4980

ggtgagaaga gaatcactga cctgtactac aagagatccg gtgattacaa gctgtcatct     5040

gccatcaagg acttgacggt gctgaagtcc accggctcga tgttctacgg ctacaacaag     5100

tgtgacttca ccaccttgca accaaccact gacagaatct tgtccaccga cgtcgatgcc     5160

acctgggttt gggataacaa gaagattggc actgtctacg acatcgccaa ggctgcagac     5220

aaggggatct ttgacaacgt ttacaaccag gctagagaga tcaccttgac caccttcgcc     5280

ctggagaact ctccatctgt gcaggccacg atgttcaaca tggctactca gatcttggaa     5340

aaggcatgct ctgtctactc ggtttcatac gccttgccaa acaagcacta cttcctcatt     5400

gacttgaaat ggaaaggttt ggagaacgac aacgagttgt tctacccatc tccacatcca     5460

aatggtttga tcaagtgtac tgttgtccgt aaggagaaga ccaagttgta agtgcatcat     5520

tgacctttct aatgaaacca cacgtgaatt aaaggaaagc gcgcagcagc agcagcagct     5580

tttctttcct tcttcaaatc ataccttttc tctatttcaa cgttcttttc atttcaccat     5640

gaaatgagtt gaattgttgc tttgagttta cgacgataca taaatattaa ttaaaatacg     5700

aaaaatacac actacttatt cccttcgaga ttatatctag gaacccatca ggttggtgga     5760

agattacccg ttctaagact tttcagcttc ctctattgat gttacacctg gacacccctt     5820

ttctggcatc cagtttttaa tcttcagtgg catgtgagat tctccgaaat taattaaagc     5880

aatcacacaa ttctctcgga taccacctcg gttgaaactg acaggtggtt tgttacgcat     5940

gctaatgcaa aggagcctat atacctttgg ctcggctgct gtaacaggga atataaaggg     6000

cagcataatt taggagttta gtgaacttgc aacatttact attttccctt cttacgtaaa     6060

tatttttctt tttaattcta aatcaatctt tttcaatttt ttgtttgtat tcttttcttg     6120

cttaaatcta taactacaaa aaacacatac ataaactaaa agtgttgaca attaatcatc     6180

ggcatagtat atcggcatag tataatacga caaggtgagg aactaaacca tgggtaagga     6240

aaagactcac gtttcgaggc cgcgattaaa ttccaacatg gatgctgatt tatatgggta     6300

taaatgggct cgcgataatg tcgggcaatc aggtgcgaca atctatcgat tgtatgggaa     6360

gcccgatgcg ccagagttgt ttctgaaaca tggcaaaggt agcgttgcca atgatgttac     6420

agatgagatg gtcagactaa actggctgac ggaatttatg cctcttccga ccatcaagca     6480

ttttatccgt actcctgatg atgcatggtt actcaccact gcgatccccg gcaaaacagc     6540

attccaggta ttagaagaat atcctgattc aggtgaaaat attgttgatg cgctggcagt     6600

gttcctgcgc cggttgcatt cgattcctgt ttgtaattgt ccttttaaca gcgatcgcgt     6660

atttcgtctc gctcaggcgc aatcacgaat gaataacggt ttggttgatg cgagtgattt     6720

tgatgacgag cgtaatggct ggcctgttga acaagtctgg aaagaaatgc ataagctttt     6780

gccattctca ccggattcag tcgtcactca tggtgatttc tcacttgata accttatttt     6840

tgacgagggg aaattaatag gttgtattga tgttggacga gtcggaatcg cagaccgata     6900

ccaggatctt gccatcctat ggaactgcct cggtgagttt tctccttcat tacagaaacg     6960

gctttttcaa aaatatggta ttgataatcc tgatatgaat aaattgcagt ttcatttgat     7020

gctcgatgag tttttctaat cagtactgac aataaaaaga ttcttgtttt caagaacttg     7080

tcatttgtat agttttttta tattgtagtt gttctatttt aatcaaatgt tagcgtgatt     7140

tatatttttt ttcgcctcga catcatctgc ccagatgcga agttaagtgc gcagaaagta     7200

atatcatgcg tcaatcgtat gtgaatgctg gtcgctatac tgtgcttaat tagcttgtac     7260

atggctttgt ggtttctgcc ataacaagct tcgttaccca aggaccagat aataatcgaa     7320

ggatgattga catctcttag gacaagttgg gaagctctgt ctaagtacgc gacctcgtac     7380

tctggattat ctgataagta atgggcatta acatcgtaga gtttattttt ggtatctgga     7440

tattcagcct ccaagttcgt atgacgatta aatggctctt gaacaccgtg agtttcaaga     7500

tctgcctcat caatgaccca gaagcctagt ttatcgaaga ggtcatacac cttaggatgg     7560

tttggataat gcgagttacg aacagcattg atgttaaact tcttcattag aatcaagtct     7620

ctaacaacaa aatctaatgg cacagctcta ccgaaccttg gatggtgatc atgcctgttg     7680

acacctctaa agagaatgtc tttgccatta acagtaatgt taccgtcctt caactccact     7740

tgtctgaaac caacatggtg cttaatagat tgaatcacac tgccatcaga tccaattaaa     7800

tccaactggt acttgtacaa agtaggattt tctgcggtcc aatgttctgg ggccttgacg     7860

ttgatcttga aagctgtttc ttcgtccttt ttggtcgaaa aggaaataaa ttctttagtt     7920

gaaaacgtcg tgttcccatt ctcctcgttc aacaaagagc ttgcatcgta aactttagat     7980

ccatcttcag gttcgtaaag tgtgaaattg atgtgatcat aagaagaacc ctggacatca     8040

actttcacag aaagctctgc atcctgatac tgagagtcca caaaagttgt agtgacccta     8100

acgtcttcaa tatgggcctt ggcgcgcc                                        8128


<210>  25
<211>  970
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct / Zygosaccharomyces parabailii uricase

<400>  25
taagaactta gtttcgaagt taacatttaa atcaaacaaa atgtcctacc tcgcagactc       60

gacttacggt aaagataatg tcaaattcct caaagttaag aaggaccctt ccaaccctaa      120

gttacaacaa gtgatggagg ctactgtcaa agttttgctc agaggtaact ttgatgtttc      180

ttacaccgag gctgacaact ccccaattgt gcctaccgac actgtgaaga acaccatctt      240

gattctagcc agacagaacg atacttggcc cactgaaaaa tttgctgcca agttagccct      300

tcactttaca ggcaagtaca gccatgtttc tggtgtctct atcaagatct accaagagcg      360

ttgggtaaaa tacgatgttg atggaagacc tagccagcat tcttttgtgc accaaggacc      420

tgaaaagaaa atcgtagaac tagaatatga caaggttaac ggtcctactc actacaaatt      480

gagcaccagc atcaaggact tgacagtgct caaatcgacc aactcgatgt tctacgacta      540

caacgtctgc gagtacacta ctttgaagcc taccaccgat cgtgttttgt ccaccgacat      600

ctttgccgta tgggactggt ctgcctcgaa gttgggtcct ctaaccgcta tcgctgcagg      660

cgcatctgac cttgtctttg acaaggtgtt taatgatgcc cgtgatatta ctttggatat      720

cttcgccaag gagaactctg tatcggtaca ggctaccatg tacaacatgg gtgttgccat      780

cttagccaag gcacctcaag tcgaatacgt ttcttacgaa ttgcccaaca agcactatat      840

tctgtttgat ttgaaatggt tccaaggatt gtccaacgac aacgagctct tctatccatc      900

tcctcatcct aatgggttga tcagatgtaa ggttggccgt aagacttcca agctatagtc      960

acatatgaaa                                                             970


<210>  26
<211>  2410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct / Zygosaccharomyces parabailii uric acid 
       transporter

<400>  26
ctaatcccgg gatccggtac cgcctcttat cgagaaagaa attaccgtcg ctcgtgattt       60

gtttgcaaaa agaacaaaac tgaaaaaacc cagacacgct cgacttcctg tcttcctatt      120

gattgcagct tccaatttcg tcacacaaca aggtcctagc gacggctcac aggttttgta      180

acaagcaatc gaaggttctg gaatggcggg aaagggttta gtaccacatg ctatgatgcc      240

cactgtgatc tccagagcaa agttcgttcg atcgtactgt tactctctct ctttcaaaca      300

gaattgtccg aatcgtgtga caacaacagc ctgttctcac acactctttt cttctaacca      360

agggggtggt ttagtttagt agaacctcgt gaaacttaca tttacatata tataaacttg      420

cataaattgg tcaatgcaag aaatacatat ttggtctttt ctaattctta gtttttcaag      480

ttcttagatg ctttcttttt ctctttttta cagatcatca aggaagtaat tatctacttt      540

ttacaacaaa tataaaacaa tggactctgt acttgaacaa ccaacaaatt ctccttctca      600

gaagatcaag ggatacttct catggttgcg cttcaaattc acaaccagag atggtctctt      660

aggtgactat gactacaaat atctattcac accctcatac ccatttcacg atttcatctg      720

cagactcagg ggcgttgagg tggtcgtgag ggatcaacct ttctttggac tgaacgaaga      780

agtccctgta cttcttggaa tgattctagg cttccagcat gcattggcta tgcttgcagg      840

tgtcataaca cctcctatga tgatagcgag tgcagcaaac ctggattccg tactgaccaa      900

ctatctcgtc tctgcatctt tgattacatc tggtatccta tctgctgtgc aaattacacg      960

ttttcatatc cccaagacta attattacat aggatctggt gtcctttcta ttgtgggaac     1020

ctcctttgcc gtgctgggaa tcgtggacaa atctgtgcct ctcatgtact caacgggata     1080

ctgtccaggg ggtgccaata gtaaagaggc ctgcccagat ggctatggtg cgttgcttgg     1140

tactgcagcg tgctgtgctc tgttggaaat gcttctatca ttcactcctc ctcatattct     1200

gcaaaagatc ttccccaagc aggtcacagg ccccgttgtt ctgaccattg ctgttccctt     1260

gatccagagt ggatttgaag attgggttgg aggctctggc tgcgttggtg caatttgtcc     1320

ttccgaaggt gctccgcagg cggcgccttg ggggtctgcc aaattcattg gtttaggttt     1380

cctggtttac acgacaatta ttctctgtga gaaatacggc ccccccattc taaaatcctg     1440

tgctgtcatc gttggcttgt tggtgggatg tatcgtggct gccgcatgtg gctactttca     1500

gcatgatatg attgatgtag cacctgcagc aacatttcta tggaaacaca cgtttagact     1560

gagggtatat gggccagcgg tgctaccatt tcttgtgatg tttattgtgc ttgcccagga     1620

gtgtattggt gatattacag cgacaagtga tgtgtcgcgg ttggaagtcg agggcgaggc     1680

gtatgagtca agaattcaag gtgcagtcct atctgatggt attggtggta tcttatcttc     1740

acttttcaca gtgactccca tgagtacctt cgctcagaac aacggtgtca tttctttgac     1800

caagtgtgct agtcgtcaag cgggttattg gacttgcttc tacatgctta tcatgggtat     1860

ctttgcaaaa ttcggtgcag ccatcgtgca gatccccaaa cctgtcctgg gcggtatgac     1920

aactttcctt ttcaccacag tggccgtggc aggtatcaaa atcatatcag aaattccttt     1980

tacgagaagg gacagatttg tgttgactgg agctctccta ccaggttttg gctctattct     2040

tgtaagcgac tggtttgact acgtctttac ctacaagggt aacaaccatg cattagaggg     2100

gtttttcaat gccattattt tgattatgga gaccagtttc accgtatgcg gtttgaccgc     2160

tatcatccta aaccttttga taccgcaaga gcttgacgaa gagctattgg acgatatcga     2220

ggtacaacaa gaaaacttaa gtgttttgga gggtagaaaa agccccttga ttggacctgt     2280

gatgtctggc aaggaaattg aagcatttga gctaagcagc gaacaaagga cttctgatcc     2340

atgaacagaa gacgggagac actagcacac aactttacca ggcaaggtat ttgacgctag     2400

catgtgtcca                                                            2410


