                         SEQUENCE LISTING

<110>  ONCOIMMUNIN INC. 
         PACKARD, BEVERLY
       KOMORIYA, AKIRA
 
<120>  TARGETED AND LOCALIZED IN VIVO DELIVERY OF OLIGONUCLEOTIDES

<130>  6673.0007

<140>  To be assigned
<141>  2021-01-11

<150>  62/959,928 
<151>  2020-01-11

<160>  87

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthesized complement of Beta-actin

<400>  1
cccggcgata tcatcatcca taac                                              24


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PKC-alpha binding oligonucleotide

<400>  2
gttctcgctg gtgagtttca                                                   20


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P53 binding oligonucleotide

<400>  3
ccctgctccc ccctggctcc                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H-Ras binding oligonucleotide

<400>  4
tccgtcatcg ctcctcaggg                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ha-Ras binding oligonucleotide

<400>  5
gggactcctc gctactgcct                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  c-Raf binding oligonucleotide

<400>  6
tcccgcctgt gacatgcatt                                                   20


<210>  7
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bcl2 binding oligonucleotide

<400>  7
tctcccagcg tgcgccat                                                     18


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VEGF binding oligonucleotide

<400>  8
tggcttgaag atgtactcga t                                                 21


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ribonucleotide Reductase R2 binding oligonucleotide

<400>  9
ggctaaatcg ctccaccaag                                                   20


<210>  10
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  c-myb binding oligonucleotide

<400>  10
tatgctgtgc cggggtcttc gggc                                              24


<210>  11
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bcr-abl binding oligonucleotide

<400>  11
cgctgaaggg cttcttcctt attgat                                            26


<210>  12
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bcr-abl binding oligonucleotide

<400>  12
cgctgaaggg ctttgaactg tgctt                                             25


<210>  13
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pka-rIA binding oligonucleotide

<400>  13
gcgugcctcc tcacuggc                                                     18


<210>  14
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  c-Myc binding oligonucleotide

<400>  14
aacgttgagg ggcat                                                        15


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  JNK2 binding oligonucleotide

<400>  15
gctcagtgga catggatgag                                                   20


<210>  16
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGF1-R binding oligonucleotide

<400>  16
ggaccctcct ccggagcc                                                     18


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTEN binding oligonucleotide

<400>  17
ctgctagcct ctggatttga                                                   20


<210>  18
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TLR9 binding oligonucleotide

<400>  18
tgactgtgaa cgttcgagat ga                                                22


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICAM-1 binding oligonucleotide

<400>  19
gcccaagctg gcatccgtca                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TNF-alpha binding oligonucleotide

<400>  20
gctgattaga gagaggtccc                                                   20


<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Adenosine A1 receptor binding oligonucleotide

<400>  21
gatggagggc ggcatggcgg g                                                 21


<210>  22
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HIV/Gag binding oligonucleotide

<400>  22
ctctcgcacc catctctctc cttct                                             25


<210>  23
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV IE2 binding oligonucleotide

<400>  23
gcgtttgctc ttcttcttgc g                                                 21


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCV binding oligonucleotide

<400>  24
gtgctcatgg tgcacggtct                                                   20


<210>  25
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV binding oligonucleotide

<400>  25
tcgtcgtttt gtcgttttgt cgtt                                              24


<210>  26
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RSV RSV binding oligonucleotide

<400>  26
ggcucuuagc aaagucaagu ugaaugau                                          28


<210>  27
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RSV binding oligonucleotide

<400>  27
aucauucaac uugacuuugc uaagagccau                                        30


<210>  28
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RSV RSV binding oligonucleotide


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-deoxythymidines

<400>  28
cgauaauaua acugcaagan n                                                 21


<210>  29
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RSV binding oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxythymidines

<400>  29
nngcuauuau auugacguuc u                                                 21


<210>  30
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RSV binding oligonucleotide


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-deoxythymidines

<400>  30
ugcuguaaca gaauugcagn n                                                 21


<210>  31
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RSV binding oligonucleotide


<220>
<221>  misc_features
<222>  (20)..(21)
<223>  2'-deoxythymidines

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is a, c, g, or u

<400>  31
cugcaauucu guuacagcan n                                                 21


<210>  32
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VP35 binding oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is Amino dT c6

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is Amino dT c6

<400>  32
ncctgccctt tgttctagtt gn                                                22


<210>  33
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ebola VP35 binding oligonucleotide

<400>  33
gcgacaucuu cugugauauu g                                                 21


<210>  34
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ebola VP35 binding oligonucleotide

<400>  34
auaucacaga agaugucgcu u                                                 21


<210>  35
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ebola VP35 binding oligonucleotide

<400>  35
cauuacgagu cuugagaau                                                    19


<210>  36
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ebola VP35 binding oligonucleotide

<400>  36
ucucaagacu cguaaugcg                                                    19


<210>  37
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ebola VP35 binding oligonucleotide

<400>  37
gcaacucauu ggacaucauu c                                                 21


<210>  38
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ebola VP35 binding oligonucleotide

<400>  38
augaugucca augaguugcu a                                                 21


<210>  39
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ebola VP35 binding oligonucleotide

<400>  39
ugaugaagau uaagaaaaa                                                    19


<210>  40
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ebola VP35 binding oligonucleotide

<400>  40
uuucuuaauc uucaucacu                                                    19


<210>  41
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ebola VP35 binding oligonucleotide

<400>  41
gugcugagau gguugcaaa                                                    19


<210>  42
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ebola VP35 binding oligonucleotide

<400>  42
ugcaaccauc ucagcacaa                                                    19


<210>  43
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ebola VP35 binding oligonucleotide

<400>  43
gcuaaugacc ggaagaauu                                                    19


<210>  44
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ebola VP35 binding oligonucleotide

<400>  44
uucuuccggu cauuagcug                                                    19


<210>  45
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ebola VP35 binding oligonucleotide

<400>  45
ccaauuagua caagugauu                                                    19


<210>  46
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ebola VP35 binding oligonucleotide

<400>  46
ucacuuguac uaauuggug                                                    19


<210>  47
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NP binding oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is Amino dT c6

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is Amino dT c6

<400>  47
ngagaatcca tactcggaat tn                                                22


<210>  48
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NP binding oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is Amino dT c6

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is Amino dT c6

<400>  48
ngacgagaat ccatactcgg an                                                22


<210>  49
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NP binding oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is Amino dT c6

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is Amino dT c6

<400>  49
ngcatgtact tgaatttgcc n                                                 21


<210>  50
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ebola NP binding oligonucleotide


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-deoxythymidines

<400>  50
ggcaaauuca aguacaugcn n                                                 21


<210>  51
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ebola NP binding oligonucleotide

<400>  51
gcauguacuu gaauuugccu u                                                 21


<210>  52
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ebola NP binding oligonucleotide

<400>  52
gcauggagag uaugcuccuu u                                                 21


<210>  53
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ebola NP binding oligonucleotide

<400>  53
aggagcauac ucuccaugcu u                                                 21


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ebola NP binding oligonucleotide

<400>  54
atggtgattt tccgtttgat                                                   20


<210>  55
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ebola NP binding oligonucleotide

<400>  55
tcaaacggaa aatcaccat                                                    19


<210>  56
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ebola NP binding oligonucleotide

<400>  56
gagaagcaac tccaacaat                                                    19


<210>  57
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ebola NP binding oligonucleotide

<400>  57
uguuggaguu gcuucuc                                                      17


<210>  58
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA polymerase L binding oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is Amino dT c6

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is Amino dT c6

<400>  58
ntgggtatgt tgtgtagcca tn                                                22


<210>  59
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ebola L Polymerase binding oligonucleotide

<400>  59
guacgaagcu guauauaaau u                                                 21


<210>  60
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ebola L Polymerase binding oligonucleotide

<400>  60
uuuauauaca gcuucguacu u                                                 21


<210>  61
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VP24 binding oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is Amino dT c6

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is Amino dT c6

<400>  61
ngccatggtt ttttctcagg n                                                 21


<210>  62
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ebola VP24 binding oligonucleotide

<400>  62
gcugauugac cagucuuuga u                                                 21


<210>  63
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ebola VP24 binding oligonucleotide

<400>  63
caaagacugg ucaaucagcu g                                                 21


<210>  64
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ebola VP24 binding oligonucleotide

<400>  64
acggauuguu gagcaguauu g                                                 21


<210>  65
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ebola VP24 binding oligonucleotide

<400>  65
auacugcuca acaauccguu g                                                 21


<210>  66
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ebola VP24 binding oligonucleotide

<400>  66
uccucgacac gaaugcaaag u                                                 21


<210>  67
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ebola VP24 binding oligonucleotide

<400>  67
uuugcauucg ugucgaggau c                                                 21


<210>  68
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Influenza NP binding oligonucleotide

<400>  68
ggaucuuauu ucuucggag                                                    19


<210>  69
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Influenza NP binding oligonucleotide

<400>  69
cuccgaagaa auaagaucc                                                    19


<210>  70
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Influenza PA binding oligonucleotide

<400>  70
gcaauugagg agugccuga                                                    19


<210>  71
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Influenza PA binding oligonucleotide

<400>  71
ucagcgacuc cucaauugc                                                    19


<210>  72
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Influenza PB1 binding oligonucleotide

<400>  72
gaucuguucc accauugaa                                                    19


<210>  73
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Influenza PB1 binding oligonucleotide

<400>  73
uucaauggug gaacagauc                                                    19


<210>  74
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Influenza M2 binding oligonucleotide

<400>  74
acagcagaau gcuguggau                                                    19


<210>  75
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Influenza M2 binding oligonucleotide

<400>  75
auccacagca uucugcugu                                                    19


<210>  76
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTP1VB binding oligonucleotide

<400>  76
gctccttcca ctgatcctgc                                                   20


<210>  77
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  77

Pro Leu Gly Ile Ala                                                               
1               5              
cuccgaagaa auaagaucc                                                    19


<210>  78
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is 6-aminoahexanoic acid residue (C5)

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is 6-aminoahexanoic acid residue (C5)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is 6-aminoahexanoic acid residue (C5)

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is 6-aminoahexanoic acid residue (C5)

<400>  78

Glu Xaa Lys Asp Pro Xaa Gly Pro Leu Gly Ile Ala Gly Ile Gly Xaa 
1               5                   10                  15      

Pro Lys Xaa Gly Cys Gly Tyr
            20 

<210>  79
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kras binding oligonucleotide

<400>  79
taggaaaagc tattaggagt ctttatagta ta                                    32


<210>  80
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Arm oligonucleotide

<400>  80
cucuccttct agcctccgct agtcaaaauu                                        30


<210>  81
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Arm oligonucleotide

<400>  81
attttgacta gcggaggcta gaaggaga                                          28


<210>  82
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BCL2 binding oligonucleotide

<400>  82
aaggcatccc agcctccgtt                                                   20


<210>  83
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BCL2 binding oligonucleotide

<400>  83
ccacaaaggc atcccagcct ccgttatcct                                        30


<210>  84
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KRAS oligonucleotide

<400>  84
auacuaaauc auuugaagau auucaccaut                                        30


<210>  85
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KRAS oligonucleotide

<400>  85
tauggugaau aucuucaaau gauuuaguau                                        30


<210>  86
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KRAS oligonucleotide

<400>  86
aguacagugc aaugagggac caguacauga t                                      31


<210>  87
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KRAS oligonucleotide

<400>  87
tucauguacu ggucccucau ugcacuguac u                                      31








